清水 俊一
| 薬学部 薬学科 | 教授 |
Last Updated :2025/06/19
■プロフィール情報
■業績リスト
論文
- Chemotherapy-induced neutropenia as a prognostic factor in patients with unresectable pancreatic cancer.
共著, Cancer Chemother Pharmacol., 76, 1217-1224, 2015年12月 - Identification of regulatory sites in the biosynthesis of ubiquinone in the perfused rat heart.
共著, Arch. Biochem. Biophys., 269, 86-92, 1989年01月 - Possible existence of an intermediate pool of ubiquinone in rat heart mitochondria.
共著, Int. J. Biochem., 22, 89-91, 1990年01月 - Inhibition of ubiquinone synthesis in isolated rat heart under an ischemic condition.
共著, Int. J. Biochem., 22, 477-480, 1990年05月 - Possible involvement of 3-hydroxymethylglutaryl-CoA reductase in determining the side-chain length of ubiquinone in rat heart.
共著, Arch. Biochem. Biophys., 284, 35-39, 1991年02月 - Inhibition by methylene blue of the L-arginine metabolism to L-citrulline coupled with nitric oxide synthesis in cultured endothelial cells.
共著, Res. Commun. Chem. Pathol. Pharmacol., 82, 35-48, 1993年10月 - Stimulation by hydrogen peroxide of L-arginine metabolism to L-citrulline coupled with nitric oxide synthesis in cultured endothelial cells.
共著, Res. Commun. Chem. Pathol. Pharmacol., 84, 315-329, 1994年06月 - Bradykinin induces generation of reactive oxygen species in bovine aortic endothelial cells.
共著, Res. Commun. Chem. Pathol. Pharmacol., 84, 301-314, 1994年06月 - Reduction by NG-nitro-L-arginine of H2O2-induced endothelial cell injury.
共著, Br. J. Pharmacol., 113, 564-568, 1994年10月 - The effects of hypoxia on pHi in porcine coronary artery endothelium and smooth muscle. A novel method for measurement in endothelial cell in situ.
共著, Circ. Res., 80, 21-27, 1997年01月 - Acceleration of oxidative stress-induced endothelial cell death by nitric oxide synthase dysfunction accompanied with decrease in tetrahydrobiopterin content.
共著, Life Sci., 61, 739-747, 1997年02月 - Mechanism of nitric oxide production induced by H2O2 in cultured endothelial cells.
共著, Res. Commun. Chem. Pathol. Pharmacol., 95, 227-239, 1997年03月 - The endothelium-dependent, substance P relaxation of porcine coronary arteries resistant to nitric oxide synthesis inhibition is partially mediated by 4-aminopyridine-sensitive voltage-dependent K+ channels.
共著, Endothelium, 5, 287-295, 1997年04月 - Possible involvement of nitric oxide synthase in oxidative stress-induced endothelial cell injury.
共著, Pharmacol. Toxicol., 80, 191-196, 1997年04月 - Changes in nitric oxide synthase activity during exposure to hydrogen peroxide in cultured endothelial cells.
共著, Res. Commun. Chem. Pathol. Pharmacol., 97, 279-289, 1997年09月 - Cold storage induces an endothelium-independent relaxation to hypoxia/reoxygenation in porcine coronary arteries.
共著, J. Vasc. Res., 34, 399-407, 1997年09月 - Reduction by tetrahydrobiopterin of H2O2-induced endothelial cell injury.
共著, Pharmacol. Toxicol., 82, 280-286, 1998年01月 - Stimulation of nitric oxide synthase during oxidative endothelial cell injury.
共著, Biochem. Pharmacol., 55, 77-83, 1998年01月 - Ets-1 is an early response gene activated by ET-1 and PDGF-BB in vascular smooth muscle cells.
共著, Am. J. Physiol., 274, C472-C480, 1998年02月 - Protective effects of tetrahydrobiopterin against nitric oxide induced endothelial cell death.
共著, Life Sci., 63, 1585-1592, 1998年02月 - Molecular cloning and functional characterization of a novel receptor-activated TRP Ca2+ channel from mouse brain.
共著, J. Biol. Chem., 273, 10279-10287, 1998年04月 - Insulin stimulates tetrahydrobiopterin synthesis in mouse brain microvascular endothelial cells.
共著, Pteridines, 10, 213-216, 1999年01月 - Stimulation of in vitro angiogenesis by hydrogen peroxide and the relation with ETS-1 in endothelial cells.
共著, Life Sci., 64, 249-258, 1999年01月 - Stimulation of in vitro angiogenesis by tetrahydrobiopterin in bovine aortic endothelial cells.
共著, Jpn. J. Pharmacol., 80, 177-180, 1999年01月 - Characterization of the protective effect of tetrahydrobiopterin against S-nitroso-N-acetyl-D,L-penicillamine induced endothelial cell injury.
共著, Pteridines, 10, 14-19, 1999年01月 - SIN-1-induced cytotoxicity in cultured endothelial cells involves reactive oxygen species and nitric oxide: protective effect of sepiapterin.
共著, J. Cardiovasc. Pharmacol., 33, 295-300, 1999年02月 - Presence of excess tetrahydrobiopterin during nitric oxide production from inducible nitric oxide synthase in LPS-treated rat aorta.
共著, Life Sci., 65, 2769-2779, 1999年02月 - [Ca2+]i homeostasis and cyclic nucleotide relaxation in aorta of phospholamban-deficient mice.
共著, Am. J. Physiol., 277, H963-H970, 1999年09月 - Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7.
共著, J. Biol. Chem., 274, 27359-27370, 1999年09月 - Hypoxia and alkalinization inhibit endothelium-derived nitric oxide but not endothelium-derived hyperpolarizing factor responses in porcine coronary artery.
共著, J. Pharmacol. Exp. Ther., 291, 335-344, 1999年10月 - Troglitazone stimulates the insulin-induced tetrahydrobiopterin synthesis in vascular endothelial cells.
共著, Pteridines, 11, 137-141, 2000年01月 - Stimulation of tetrahydrobiopterin synthesis by 17β-estradiol in brain microvascular endothelial cells.
共著, Pteridines, 11, 129-132, 2000年01月 - Involvement of reactive oxygen species and nitric oxide in gastric ischemia-reperfusion injury in rats.
共著, Dig. Dis. Sci., 45, 93-98, 2000年01月 - Role of voltage-dependent and Ca2+-activated K+ channels on the regulation of isometric force in porcine coronary artery.
共著, J. Vasc. Res., 37, 16-25, 2000年01月 - Effects of hypoxia on isometric force, intracellular Ca2+, pH, and energetics in porcine coronary artery.
共著, Circ. Res., 86, 862-870, 2000年04月 - A novel effect of polymorphonuclear leukocytes in the facilitation of angiogenesis.
共著, Life Sci., 66, 2113-2121, 2000年05月 - Stimulation of tetrahydrobiopterin synthesis induced by insulin: possible involvement of phosphatidylinositol 3-kinase.
共著, Int. J. Biochem. Cell Biol., 33, 65-73, 2001年01月 - Negative regulation of insulin-induced tetrahydrobiopterin synthesis by protein kinase C in vascular endothelial cells.
共著, Pteridines, 12, 161-166, 2001年01月 - The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha1-adrenoceptor-activated Ca2+-permeable cation channel.
共著, Circ. Res., 88, 325-332, 2001年02月 - Hypoxic vasodilation in porcine coronary artery is preferentially inhibited by organ culture.
共著, Am. J. Physiol., 281, C24-C32, 2001年07月 - Carboxy-PTIO increases the tetrahydrobiopterin level in mouse brain microvascular endothelial cells.
共著, Jpn. J. Pharmacol., 87, 51-60, 2001年09月 - LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death.
共著, Mol. Cell, 9, 163-173, 2002年01月 - Stimulation of tetrahydrobiopterin synthesis by cyclosporin A during lipopolysaccharide treatment in vascular endothelial cells.
共著, Pteridines, 13, 89-93, 2002年01月 - Hydrogen peroxide stimulates the LPS-induced tetrahydrobiopterin synthesis in mouse brain microvascular endothelial cells.
共著, Pteridines, 13, 21-25, 2002年01月 - Ets-1 upregulates matrix metalloproteinase-1 expression through extracellular matrix adhesion in vascular endothelial cells.
共著, Biochem. Biophys. Res. Commun., 291, 130-138, 2002年02月 - Differential roles of ICAM-1 and E-selectin in polymorphonuclear leukocyte-induced angiogenesis.
共著, Am. J. Physiol., 282, C917-C925, 2002年04月 - Stimulation of tetrahydrobiopterin synthesis by cyclosporin A in mouse brain microvascular endothelial cells.
共著, Int. J. Biochem. Cell Biol., 34, 1134-1141, 2002年09月 - Stimulation of tetrahydrobiopterin synthesis by basic fibroblast growth factor in vascular endothelial cells.
共著, Pteridines, 14, 9-12, 2003年01月 - Decrease in tetrahydrobiopterin content promotes L-arginine-induced elevation of cytosolic calcium concentration in insulin-secreting cells.
共著, Pteridines, 14, 119-125, 2003年01月 - Stimulation of tetrahydrobiopterin synthesis by peroxynitrite in vascular endothelial cells.
共著, Pteridines, 14, 114-118, 2003年01月 - Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through the induction of GTP-cyclohydrolase I and increases nitric oxide synthase activity in vascular endothelial cells.
共著, Free Radic. Biol. Med., 34, 1343-1352, 2003年03月 - Stimulation of in vitro angiogenesis by nitric oxide through the induction of transcription factor ETS-1.
共著, Int. J. Biochem. Cell Biol., 36, 114-122, 2004年01月 - Reduction of GTP cyclohydrolase I feedback regulating protein expression by hydrogen peroxide in vascular endothelial cells.
共著, J. Pharmacol. Sci., 97, 299-302, 2005年02月 - Possible involvement of hydroxyl radical on the stimulation of tetrahydrobiopterin synthesis by hydrogen peroxide and peroxynitrite in vascular endothelial cells.
共著, Int. J. Biochem. Cell Biol., 37, 864-875, 2005年04月 - Intracellular-produced hydroxyl radical mediates H2O2-induced Ca2+ influx and cell death in rat β-cell line RIN-5F.
共著, Cell Calcium, 39, 487-494, 2006年01月 - Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells.
共著, J. Physiol., 570, 219-235, 2006年01月 - Extracellular-added ADP-ribose increases intracellular free Ca2+ concentration through Ca2+ release from stores, but not through TRPM2-mediated Ca2+ entry, in rat b-cell line RIN-5F.
共著, J. Pharmacol. Sci., 101, 174-178, 2006年01月 - Tetrahydrobiopterin regulates L-tyrosine-induced elevation of cytosolic calcium concentration in insulin-secreting cells.
共著, Pteridines, 17, 69-73, 2006年01月 - Reduction of myocardial infarct size by tetrahydrobiopterin: Possible involvement of mitochondrial KATP channels activation through nitric oxide production.
共著, J. Cardiovasc. Pharmacol., 47, 243-249, 2006年02月 - Influence of SNPs in cytokine-related genes on the severity of food allergy and atopic eczema in children.
共著, Pediatr. Allergy Immunol., 17, 583-590, 2006年12月 - Nitric oxide activates TRP channels by cysteine S-nitrosylation.
共著, Nat. Chem. Biol., 2, 596-607, 2006年12月 - Facilitation of H2O2-induced A172 human glioblastoma cell death by insertion of oxidative stress-sensitive TRPM2 channels.
共著, Anticancer Res., 27, 3987-3992, 2007年11月 - Insulin secretion in response to L-arginine under decreasing tetrahydrobiopterin content.
共著, Pteridines, 19, 93-100, 2008年01月 - Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through activation of the Jak2 tyrosine kinase pathway in vascular endothelial cells.
共著, Int. J. Biochem. & Cell Biol., 40, 755-765, 2008年04月 - TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration.
共著, Nat. Med., 14, 738-747, 2008年07月 - Inhibitory effect of lomerizine , a prophylactic drug for migraines, on serotonin-induced contraction of the basilar artery.
共著, J. Pharmacol. Sci., 111, 221-225, 2009年10月 - An important role of increase in tetrahydrobiopterin via H2O2/Jak2 signaling pathway in late phase of ischaemic preconditioning.
共著, Exp. Physiol., 95, 609-621, 2010年03月 - Association of the A-1483G polymorphism in serotonin 2A receptor in migraine with aura among Japanese patients.
共著, Biol. Pharm. Bull., 33, 1751-1753, 2010年10月 - Impaired Ca2+ regulation of CD4+CD25+ regulatory Y cells from pediatric asthma.
共著, Int. Arch. Allergy Immunol.,156, 148-158, 2011年02月 - Negative predictors of clinical response to triptans in patients with migraine.
共著, Neurol. Sci., 33, 453-461, 2011年04月 - AW551984: a novel regulator of cardiomyogenesis in pluripotent embryonic cells.
共著, Biochem. J. 437, 345-355, 2011年07月 - Neuroprotection by lomerizine, a prophylactic drug for migraine, against hydrogen peroxide-induced hippocampal neurotoxicity.
共著, Mol. Cell. Biochem. 358, 1-11, 2011年12月 - Possible involvement of transient receptor potential channels in electrophile-induced insulin secretion from RINm5F cells.
共著, Biol. Pharm. Bull., 35, 346-354, 2012年03月 - MAOA, MTHFR, and TNF-genes polymorphisms and personality traits in the pathogenesis of migraine.
共著, Mol. Cell. Biochem., 363, 357-366, 2012年04月 - Association between the G252A Tumor Necrosis Factor-β Gene Polymorphism and Medication-Overuse Headache.
共著, J Clin Neurol., 8, 301-304, 2012年12月 - Predictive index for the onset of medication overuse headache in migraine patients.
共著, Neurol. Sci. 34, 85-92, 2013年01月 - Metformin Modulates GLP-1- and GIP-Mediated Intracellular Signaling under Normoglycemic Conditions.
共著, Open J. Endo. Metabolic Dis., 3, 263-270, 2013年01月 - Neutrophil TRPM2 channels are implicated in the exacerbation of myocardial ischaemia/reperfusion injury.
共著, Cardiovasc. Res., 97, 271-281, 2013, 2013年02月 - Decreased cardiac mitochondrial tetrahydrobiopterin in a rat model of pressure overload.
共著, Int. J. Mol. Med., 31, 589-596, 2013, 2013年03月 - Tryptophan Hydroxylase 2 Gene Polymorphisms in Japanese Patients with Medication Overuse Headaches.
共著, Acta Neurol Taiwan, 22, 147-151, 2013, 2013年12月 - Characteristics of inconsistent responders to prophylaxis therapy with lomerizine in patients with migraine: A retrospective st
共著, J. Neurol. Sci., 335, 118-123, 2013, 2013年12月 - Potentiated macrophage activation by acid sensing under low adiponectin levels.
共著, Mol. Immunol., 57, 141-150, 2014, 2014年02月 - Polymorphisms of nitric oxide synthase and GTP cyclohydrolase I genes in Japanese patients with medication overuse headaches.
共著, Neurology Asis, 19, 277-281, 2014, 2014年03月 - Involvement of TRPM2 and L-type Ca2+ channels in Ca2+ entry and cell death induced by hydrogen peroxide in rat -cell line RIN-5
共著, J Toxicol Sci, 39, 199-209, 2014, 2014年04月 - Influence of the Tohoku-Pacific Ocean Earthquake and Its Aftershocks on the Response to Prophylactic Therapy with Lomerizine in
共著, Eur. Neurol., 71, 252?258, 2014, 2014年05月 - MAOA and TNF-gene polymorphisms are associated with photophobia but not osmophobia in patients with migraine.
共著, Acta Neurol Taiwan, 23, 40-48, 2014, 2014年06月 - Elevated receptor for activated C kinase 1 expression is involved in intracellular Ca2+ influx and potentially associated with
共著, Clin Exp Allergy, 44, 1154-1169, 2014, 2014年09月 - Inhibitory effects of AG490 on H2O2-induced TRPM2-mediated Ca2+ entry.
共著, Eur J Pharmacol, 742, 22-30, 2014, 2014年11月 - A cyclooxygenase 2 gene polymorphism is a risk factor for the complication of medication overuse headaches in patients with mig
共著, J Neurol Disord, 3 (1), doi.prg/10.4172/2329-6895.1000206, 2015, 2015年02月 - Practical prognostic index for survival in patients with unresectable pancreatic cancer treated with gemcitabine or S-1.
共著, Hepatogastroenterology, 2015年03月 - TRPM2 channels in alveolar epithelial cells mediate bleomycin-induced lung inflammation.
共著, Free Radic Biol & Med., 90, 101?113, 2015年11月 - Inhibitory effects of Tyrphostin AG-related compounds on oxidative stress-sensitive transient receptor potential channel activa
共著, Eur J Pharmacol., 786, 19-28, 2016年05月 - Sensitization of H2O2-induced TRPM2 activation and subsequent interleukin-8 (CXCL8) production by intracellular Fe2+ in human m
共著, Int J Biochem & Cell Biol., 68, 119-127, 2016年11月 - Tyrphostin AG-related compounds attenuate H2O2-induced TRPM2-dependent and -independent cellular responses.
共著, J Pharmacol Sci., 134, 68-74, 2017年05月 - Protective Effects of Duloxetine against Cerebral Ischemia-Reperfusion Injury via Transient Receptor Potential Melastatin 2 Inhibition.
共著, 責任著者, 酸化ストレス感受性Ca2+透過性チャネルであるTRPM2の活性化は、脳の虚血再灌流障害に関わっていることが認められている。我々は、抗うつ薬であるデュロキセチンが強いTRPM2活性化に対する抑制作用を有しており、マウスにおける脳の虚血再灌流障害を抑制することを見出した。, 第368巻, 246, 254, 2019年02月, 有り, 無し, 英語, 研究論文（学術雑誌）, 国際誌, 国際共著していない, org/10.1124/jpet.118.253922 - Short TRPM2 prevents the targeting of full-length TRPM2 to the surface transmembrane by hijacking to ER associated degradation.
共著, Biochem Biophys Res Commun., 520, 520-525, 2019., 2019年10月 - Possible involvement of TRPM2 activation in 5-fluorouracil-induced myelosuppression in mice.
共著, Eur J Pharmacol., 891, 173671, 2021. doi : 10.1016/j.ejphar.2020.173671, 2021年01月 - 共著, 2024年01月
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書籍等出版物
- Angiogenesis induced by adhesion between polymorphonuclear leukocyte and endothelial cell via intercellular adhesion mol
共著, New Frontiers in Regenerative Medicine., 2007年06月 - Immune mechanisms of childhood asthma.
共著, InTech-Open Access Publisher, 2011年06月 - イラストでみる疾病の成り立ちと薬物療法
共著, 医学評論社, 2013年09月 - TRPs as Chemosensors (ROS, RNS, RCS, Gasotransmitters).
共著, Mammalian Transient Receptor Potential (TRP) Cation Channels, Handbook of Experimental Pharmacology 223, pp. 767-794, Springer International Publishing Switzerland, 2014年07月 - 構造式手帳
共著, 京都廣川書店, 2016年03月 - Targeting TRPM2 in ROS-coupled diseases.
共著, Pharmaceuticals, doi:10.3390/ph9030057, 2016年09月 - Significance of TRP channels in oxidative stress.
共著, Eur J Pharmacol., 793, 109-111, 2016年11月 - アルティメイト薬理学
共編者( 共編著者), 教科書・概説・概論, 京都廣川書店, 2022年03月
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その他研究業績
- Role of tetrahydrobiopterin in the function of nitric oxide synthase, and its cytoprotective effect (Review).
共著, 1998年11月, Int. J. Mol. Med., 2, 533-540, 1998. - 血管内皮由来過分極因子はK+？
単著, 1999年01月, ファルマシア, 35, 944-945, 1999 - Receptor-activated Ca2+ influx: capacitative Ca2+ entry and TRP proteins.
共著, 1999年09月, Nippon Yakurigaku Zasshi, 114, 149-160, 1999 - Protective effect of tetrahydrobiopterin against reactive oxygen species- and nitric oxide-induced vascular endothelial cell injury.
単著, 2002年01月, Pteridines, 13, 32-37, 2002 - Ca2+ channel alpha1B subunit (CaV 2.2) knockout mouse reveals a predominant role of N-type channels in the sympathetic regulation of the circulatory system.
共著, 2002年06月, Trends Cardiovasc. Med., 12, 270-274 - TRPM2 チャネルによる活性酸素シグナルの増幅と慢性炎症の関連
共著, 2009年01月, 日本薬理学雑誌 134, 122-126, 2009 - 酸化ストレス作動性TRPチャネルと消化管炎症
共著, 2011年01月, Journal of Gastrointestinal Research 19, 4-12, 2011 - 活性酸素感受性Ca2+透過性チャネルTRPM2の活性化による炎症反応の増幅
共著, 2011年01月, 生化学 83, 1100-1103, 2011
