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デュロキセチンによるTRPM2チャネル遮断を介した脳虚血-再灌流障害の抑制
Joint Author, Takahiro Toda, Shinichiro Yamamoto, Noriko Umehara, Yasuo Mori, Minoru Wakamori, and Shunichi Shimizu, Corresponding, Activation of transient receptor potential melastatin 2 (TRPM2), an oxidative stress?sensitive Ca²⁺-permeable channel, contributes to the aggravation of cerebral ischemia-reperfusion (CIR) injury. We found that antidepressant duloxetine has strong inhibitory effects on TRPM2 activation, and reduces CIR injury in mice. , J. Pharmacol.Exp. Ther., 368, 246-254, 第368巻, 246, 254, Feb. 2019, Exist, Not exist, English, Research papers (academic journals), International, Not International Collabolation, org/10.1124/jpet.118.253922

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Mouse transient receptor potential melastatin 2 (TRPM2) isoform 7 attenuates full-length mouse TRPM2 activity through reductions in its expression by targeting it to ER-associated degradation.
Joint Author, Genes cells, 29, 254-269, Jan. 2024
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Coeditor, Textbooks, Mar. 2022
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