八代田 英樹
薬学部 薬学科 | 教授 |
Last Updated :2025/06/19
■研究者基本情報
■経歴
経歴
学歴
■研究活動情報
論文
- Vacuolar Sts1 Degradation-Induced Cytoplasmic Proteasome Translocation Restores Cell Proliferation.
Noritaka Ohigashi; Shoshiro Hirayama; Hideki Yashiroda; Shigeo Murata
Genes to cells : devoted to molecular & cellular mechanisms, 2025年03月 - The Molecular Mechanisms Governing the Assembly of the Immuno- and Thymoproteasomes in the Presence of Constitutive Proteasomes.
Ayaka Watanabe; Hideki Yashiroda; Satoshi Ishihara; Megan Lo; Shigeo Murata
Cells, 2022年05月07日 - The ubiquitination-deubiquitination cycle on the ribosomal protein eS7A is crucial for efficient translation
Yuka Takehara; Hideki Yashiroda; Yoshitaka Matsuo; Xian Zhao; Akane Kamigaki; Tetsuo Matsuzaki; Hidetaka Kosako; Toshifumi Inada; Shigeo Murata
iScience, 2021年03月, [査読有り] - In-depth analysis of the lid subunits assembly mechanism in mammals
Minghui Bai; Xian Zhao; Kazutaka Sahara; Yuki Ohte; Yuko Hirano; Takeumi Kaneko; Hideki Yashiroda; Shigeo Murata
Biomolecules, 2019年06月01日 - PAC1-PAC2 proteasome assembly chaperone retains the core α4-α7 assembly intermediates in the cytoplasm.
Wu W; Sahara K; Hirayama S; Zhao X; Watanabe A; Hamazaki J; Yashiroda H; Murata S
Genes to cells : devoted to molecular & cellular mechanisms, 2018年10月, [査読有り] - The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction
Shun Koizumi; Taro u Irie; Shoshiro Hirayama; Yasuyuki Sakurai; Hideki Yashiroda; Isao Naguro; Hidenori Ichijo; Jun Hamazaki; Shigeo Murata
ELIFE, 2016年08月, [査読有り] - Proteasome Impairment Induces Recovery of Mitochondrial Membrane Potential and an Alternative Pathway of Mitochondrial Fusion
Ryohei Shirozu; Hideki Yashiroda; Shigeo Murata
MOLECULAR AND CELLULAR BIOLOGY, 2016年01月, [査読有り] - BAALC potentiates oncogenic ERK pathway through interactions with MEKK1 and KLF4
K Morita; Y Masamoto; K Kataoka; J Koya; Y Kagoya; H Yashiroda; T Sato; S Murata; M Kurokawa
Leukemia, 2015年11月, [査読有り] - Sirt1-deficiency causes defective protein quality control
Takuya Tomita; Jun Hamazaki; Shoshiro Hirayama; Michael W. McBurney; Hideki Yashiroda; Shigeo Murata
SCIENTIFIC REPORTS, 2015年07月, [査読有り] - Identification of minimum Rpn4-responsive elements in genes related to proteasome functions
Ryohei Shirozu; Hideki Yashiroda; Shigeo Murata
FEBS LETTERS, 2015年04月, [査読有り] - N-terminal α7 deletion of the proteasome 20S core particle substitutes for yeast PI31 function.
Yashiroda H; Toda Y; Otsu S; Takagi K; Mizushima T; Murata S
Molecular and cellular biology, 2015年01月, [査読有り] - Assembly mechanisms of specialized core particles of the proteasome
Minghui Bai; Xian Zhao; Kazutaka Sahara; Yuki Ohte; Yuko Hirano; Takeumi Kaneko; Hideki Yashiroda; Shigeo Murata
Biomolecules, 2014年09月01日, [査読有り] - Pba3-Pba4 heterodimer acts as a molecular matchmaker in proteasome α-ring formation.
Takagi K; Saeki Y; Yashiroda H; Yagi H; Kaiho A; Murata S; Yamane T; Tanaka K; Mizushima T; Kato K
Biochemical and biophysical research communications, 2014年07月25日, [査読有り] - The mechanism for molecular assembly of the proteasome
Kazutaka Sahara; Larissa Kogleck; Hideki Yashiroda; Shigeo Murata
Advances in Biological Regulation, 2014年, [査読有り] - Involvement of Bag6 and the TRC pathway in proteasome assembly
Takashi Akahane; Kazutaka Sahara; Hideki Yashiroda; Keiji Tanaka; Shigeo Murata
NATURE COMMUNICATIONS, 2013年07月, [査読有り] - Proteasome structure and function: From yeast to human
Hideki Yashiroda; Shigeo Murata
Seikagaku, 2012年, [査読有り] - An Inhibitor of a Deubiquitinating Enzyme Regulates Ubiquitin Homeostasis
Yoko Kimura; Hideki Yashiroda; Tai Kudo; Sumiko Koitabashi; Shigeo Murata; Akira Kakizuka; Keiji Tanaka
CELL, 2009年05月, [査読有り] - Molecular mechanisms of proteasome assembly
Shigeo Murata; Hideki Yashiroda; Keiji Tanaka
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2009年02月, [査読有り] - Dissecting beta-ring assembly pathway of the mammalian 20S proteasome
Yuko Hirano; Takeumi Kaneko; Kenta Okamoto; Minghui Bai; Hideki Yashiroda; Kaori Furuyama; Koichi Kato; Keiji Tanaka; Shigeo Murata
EMBO JOURNAL, 2008年08月, [査読有り] - Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasomes
Hideki Yashiroda; Tsunehiro Mizushima; Kenta Okamoto; Tomie Kameyama; Hidemi Hayashi; Toshihiko Kishimoto; Shin-ichiro Niwa; Masanori Kasahara; Eiji Kurimoto; Eri Sakata; Kenji Takagi; Atsuo Suzuki; Yuko Hirano; Shigeo Murata; Koichi Kato; Takashi Yamane; Keiji Tanaka
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2008年03月, [査読有り] - 【細胞内の輪廻転生 タンパク質の分解機構 ユビキチン、プロテアソーム、オートファジー、プロテオリシスなど分解装置の作動機構と病態生理作用】プロテアソーム プロテアソームの分子集合機構
平野 祐子; 八代田 英樹; 佐伯 泰
実験医学, 2008年02月 - Ubiquity and Diversity of the Proteasome System
Keiji Tanaka; Hideki Yashiroda; Shigeo Murata
Protein Degradation, 2008年01月10日, [査読有り] - The assembly pathway of the 19S regulatory particle of the yeast 26S proteasome
Erika Isono; Kiyoshi Nishihara; Yasushi Saeki; Hideki Yashiroda; Naoko Kamata; Liying Ge; Takashi Ueda; Yoshiko Kikuchi; Keiji Tanaka; Akihiko Nakano; Akio Toh-e
MOLECULAR BIOLOGY OF THE CELL, 2007年02月, [査読有り] - A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes
Jun Hamazaki; Shun-ichiro Iemura; Tohru Natsume; Hideki Yashiroda; Keiji Tanaka; Shigeo Murata
EMBO JOURNAL, 2006年10月, [査読有り] - 【ユビキチン-プロテアソーム系とオートファジー 作動機構と病態生理】ユビキチン-プロテアソーム系 プロテアソーム研究の最前線 プロテアソーム活性化因子の多様性
佐伯 泰; 八代田 英樹
蛋白質・核酸・酵素, 2006年08月 - [Demystification of deubiquitinating enzyme].
Yashiroda H; Komatsu M
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2006年08月, [査読有り] - [Diversity of proteasome activators].
Saeki Y; Yashiroda H
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2006年08月, [査読有り] - Preparation of proteasomes
Keiji Tanaka; Hideki Yashiroda; Nobuyuki Tanahashi
Cell Biology, Four-Volume Set, 2006年, [査読有り] - A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes
Y Hirano; KB Hendil; H Yashiroda; S Iemura; R Nagane; Y Hioki; T Natsume; K Tanaka; S Murata
NATURE, 2005年10月, [査読有り] - Hub1 is an essential ubiquitin-like protein without functioning as a typical modifier in fission yeast
H Yashiroda; K Tanaka
GENES TO CELLS, 2004年12月, [査読有り] - But1 and But2 proteins bind to Uba3, a catalytic subunit of E1 for neddylation, in fission yeast
H Yashiroda; K Tanaka
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003年11月, [査読有り] - The molecular chaperone Hsp90 plays a role in the assembly and maintenance of the 26S proteasome
J Imai; M Maruya; H Yashiroda; Yahara, I; K Tanaka
EMBO JOURNAL, 2003年07月, [査読有り] - Proteasomes and Molecular Chaperones Cellular Machinery Responsible for Folding and Destruction of Unfolded Proteins
Jun Imai; Hideki Yashiroda; Mikako Maruya; Ichiro Yahara; Keiji Tanaka
CELL CYCLE, 2003年, [査読有り] - Yeast Whi2 and Psr1-phosphatase form a complex and regulate STRE-mediated gene expression
D Kaida; H Yashiroda; A Toh-e; Y Kikuchi
GENES TO CELLS, 2002年06月, [査読有り] - Control of IkappaBalpha proteolysis by the ubiquitin-proteasome pathway.
Tanaka K; Kawakami T; Tateishi K; Yashiroda H; Chiba T
Biochimie, 2001年03月, [査読有り] - p57Kip2 Is Degraded through the Proteasome in Osteoblasts Stimulated to Proliferation by Transforming Growth Factor β1
Tomohiko Urano; Hideki Yashiroda; Masatoshi Muraoka; Kiyoko Tanaka; Takayuki Hosoi; Satoshi Inoue; Yasuyoshi Ouchi; Keiji Tanaka; Hideo Toyoshima
Journal of Biological Chemistry, 1999年04月, [査読有り] - The PY-motif of Bul1 protein is essential for growth of Saccharomyces cerevisiae under various stress conditions
Hideki Yashiroda; Daisuke Kaida; Akio Toh-e; Yoshiko Kikuchi
Gene, 1998年12月, [査読有り]
筆頭著者 - Isolation of a Tobacco cDNA Encoding Sar1 GTPase and Analysis of Its Dominant Mutations in Vesicular Traffic Using a Yeast Complementation System
Takeuchi M; Tada M; Saito C; Yashiroda H; Nakano A
Plant Cell Physiol., 1998年 - Bul1, a new protein that binds to the Rsp5 ubiquitin ligase in Saccharomyces cerevisiae.
H Yashiroda; T Oguchi; Y Yasuda; A Toh-E; Y Kikuchi
Molecular and Cellular Biology, 1996年07月, [査読有り]
筆頭著者
MISC
- 膜脂質異常によるIre1活性化におけるVps34の機能解明
岩田紬; 山岸洸太; ZANG Xiuwen; 八代田英樹; 村田茂穂; 新井洋由; 河野望; 青木淳賢
日本薬学会年会要旨集(Web), 2023年 - イノシトール欠乏時のIre1活性化に関わる脂質代謝酵素の探索
岩田紬; 山岸洸太; CHANG Hsiuwen; 八代田英樹; 村田茂穂; 新井洋由; 河野望; 青木淳賢
日本生化学会大会(Web), 2023年 - 効率的なタンパク質合成にはリボソームタンパク質eS7がユビキチン化と脱ユビキチン化されることが重要である
八代田英樹; 竹原由香; 松尾芳隆; ZHAO Xian; 神垣あかね; 松崎哲郎; 小迫英尊; 稲田利文; 村田茂穂
日本生化学会大会(Web), 2022年 - 出芽酵母20Sプロテアソーム形成に関わるシャペロン複合体Dmp1/Dmp2の立体構造解析
八代田 英樹; 水島 恒裕
細胞工学, 2008年04月 - 【ユビキチン-プロテアソーム系とオートファジー 作動機構と病態生理】 ユビキチン-プロテアソーム系 ユビキチン修飾 神秘のベールを脱ぎ始めた脱ユビキチン化酵素
八代田 英樹; 小松 雅明
蛋白質・核酸・酵素, 2006年08月 - Hub1 is an essential ubiquitin-like protein without functioning as a typical modifier in fission yeast
Hideki Yashiroda; Keii Tanaka
CELL STRUCTURE AND FUNCTION, 2004年05月 - Whi2 is required for general stress response in Saccharomyces cerevisiae.
D Kaida; H Yashiroda; A Toh-e; Y Kikuchi
YEAST, 2001年08月 - The role of ubiquitin ligases in the cell proliferation
H. Yashiroda; Y. Kikuchi
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1997年 - Sar1 GTPase required for ER-to-Golgitransport (2) -An approach using inducible dominant-lethalmutations in the tobacco BY-2 cells
TAKEUCHI Masaki; YASHIRODA Hideki; TAKAHASHI Yohsuke; NAGATA Toshiyuki; NAKANO Akihiko
Plant and cell physiology, 1995年03月