Hideki Yashiroda
| Faculty of Pharmaceutical Sciences,Department of Pharmaceutical Sciences | Professor |
Last Updated :2025/06/19
■Researcher basic information
■Career
Career
- Apr. 2023 - Present
Teikyo Heisei University, Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences - Feb. 2008 - Mar. 2023
The University of Tokyo, Graduate School of Pharmaceutical Sciences - Apr. 1998 - Jan. 2008
Tokyo Metropolitan Institute of Medical Science - Apr. 1995 - Mar. 1998
日本学術振興会特別研究員DC1
Educational Background
■Research activity information
Paper
- Vacuolar Sts1 Degradation-Induced Cytoplasmic Proteasome Translocation Restores Cell Proliferation.
Noritaka Ohigashi; Shoshiro Hirayama; Hideki Yashiroda; Shigeo Murata
Genes to cells : devoted to molecular & cellular mechanisms, Mar. 2025 - The Molecular Mechanisms Governing the Assembly of the Immuno- and Thymoproteasomes in the Presence of Constitutive Proteasomes.
Ayaka Watanabe; Hideki Yashiroda; Satoshi Ishihara; Megan Lo; Shigeo Murata
Cells, 07 May 2022 - The ubiquitination-deubiquitination cycle on the ribosomal protein eS7A is crucial for efficient translation
Yuka Takehara; Hideki Yashiroda; Yoshitaka Matsuo; Xian Zhao; Akane Kamigaki; Tetsuo Matsuzaki; Hidetaka Kosako; Toshifumi Inada; Shigeo Murata
iScience, Mar. 2021, [Reviewed] - In-depth analysis of the lid subunits assembly mechanism in mammals
Minghui Bai; Xian Zhao; Kazutaka Sahara; Yuki Ohte; Yuko Hirano; Takeumi Kaneko; Hideki Yashiroda; Shigeo Murata
Biomolecules, 01 Jun. 2019 - PAC1-PAC2 proteasome assembly chaperone retains the core α4-α7 assembly intermediates in the cytoplasm.
Wu W; Sahara K; Hirayama S; Zhao X; Watanabe A; Hamazaki J; Yashiroda H; Murata S
Genes to cells : devoted to molecular & cellular mechanisms, Oct. 2018, [Reviewed] - The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction
Shun Koizumi; Taro u Irie; Shoshiro Hirayama; Yasuyuki Sakurai; Hideki Yashiroda; Isao Naguro; Hidenori Ichijo; Jun Hamazaki; Shigeo Murata
ELIFE, Aug. 2016, [Reviewed] - Proteasome Impairment Induces Recovery of Mitochondrial Membrane Potential and an Alternative Pathway of Mitochondrial Fusion
Ryohei Shirozu; Hideki Yashiroda; Shigeo Murata
MOLECULAR AND CELLULAR BIOLOGY, Jan. 2016, [Reviewed] - BAALC potentiates oncogenic ERK pathway through interactions with MEKK1 and KLF4
K Morita; Y Masamoto; K Kataoka; J Koya; Y Kagoya; H Yashiroda; T Sato; S Murata; M Kurokawa
Leukemia, Nov. 2015, [Reviewed] - Sirt1-deficiency causes defective protein quality control
Takuya Tomita; Jun Hamazaki; Shoshiro Hirayama; Michael W. McBurney; Hideki Yashiroda; Shigeo Murata
SCIENTIFIC REPORTS, Jul. 2015, [Reviewed] - Identification of minimum Rpn4-responsive elements in genes related to proteasome functions
Ryohei Shirozu; Hideki Yashiroda; Shigeo Murata
FEBS LETTERS, Apr. 2015, [Reviewed] - N-Terminal alpha 7 Deletion of the Proteasome 20S Core Particle Substitutes for Yeast PI31 Function
Hideki Yashiroda; Yousuke Toda; Saori Otsu; Kenji Takagi; Tsunehiro Mizushima; Shigeo Murata
MOLECULAR AND CELLULAR BIOLOGY, Jan. 2015, [Reviewed] - Assembly mechanisms of specialized core particles of the proteasome
Minghui Bai; Xian Zhao; Kazutaka Sahara; Yuki Ohte; Yuko Hirano; Takeumi Kaneko; Hideki Yashiroda; Shigeo Murata
Biomolecules, 01 Sep. 2014, [Reviewed] - Pba3-Pba4 heterodimer acts as a molecular matchmaker in proteasome α-ring formation.
Kenji Takagi; Yasushi Saeki; Hideki Yashiroda; Hirokazu Yagi; Ai Kaiho; Shigeo Murata; Takashi Yamane; Keiji Tanaka; Tsunehiro Mizushima; Koichi Kato
Biochemical and biophysical research communications, 25 Jul. 2014, [Reviewed] - The mechanism for molecular assembly of the proteasome
Kazutaka Sahara; Larissa Kogleck; Hideki Yashiroda; Shigeo Murata
Advances in Biological Regulation, 2014, [Reviewed] - Involvement of Bag6 and the TRC pathway in proteasome assembly
Takashi Akahane; Kazutaka Sahara; Hideki Yashiroda; Keiji Tanaka; Shigeo Murata
NATURE COMMUNICATIONS, Jul. 2013, [Reviewed] - Proteasome structure and function: From yeast to human
Hideki Yashiroda; Shigeo Murata
Seikagaku, 2012, [Reviewed] - An Inhibitor of a Deubiquitinating Enzyme Regulates Ubiquitin Homeostasis
Yoko Kimura; Hideki Yashiroda; Tai Kudo; Sumiko Koitabashi; Shigeo Murata; Akira Kakizuka; Keiji Tanaka
CELL, May 2009, [Reviewed] - Molecular mechanisms of proteasome assembly
Shigeo Murata; Hideki Yashiroda; Keiji Tanaka
NATURE REVIEWS MOLECULAR CELL BIOLOGY, Feb. 2009, [Reviewed] - Dissecting beta-ring assembly pathway of the mammalian 20S proteasome
Yuko Hirano; Takeumi Kaneko; Kenta Okamoto; Minghui Bai; Hideki Yashiroda; Kaori Furuyama; Koichi Kato; Keiji Tanaka; Shigeo Murata
EMBO JOURNAL, Aug. 2008, [Reviewed] - Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasomes
Hideki Yashiroda; Tsunehiro Mizushima; Kenta Okamoto; Tomie Kameyama; Hidemi Hayashi; Toshihiko Kishimoto; Shin-ichiro Niwa; Masanori Kasahara; Eiji Kurimoto; Eri Sakata; Kenji Takagi; Atsuo Suzuki; Yuko Hirano; Shigeo Murata; Koichi Kato; Takashi Yamane; Keiji Tanaka
NATURE STRUCTURAL & MOLECULAR BIOLOGY, Mar. 2008, [Reviewed] - 【細胞内の輪廻転生 タンパク質の分解機構 ユビキチン、プロテアソーム、オートファジー、プロテオリシスなど分解装置の作動機構と病態生理作用】プロテアソーム プロテアソームの分子集合機構
平野 祐子; 八代田 英樹; 佐伯 泰
実験医学, Feb. 2008 - Ubiquity and Diversity of the Proteasome System
Keiji Tanaka; Hideki Yashiroda; Shigeo Murata
Protein Degradation, 10 Jan. 2008, [Reviewed] - The assembly pathway of the 19S regulatory particle of the yeast 26S proteasome
Erika Isono; Kiyoshi Nishihara; Yasushi Saeki; Hideki Yashiroda; Naoko Kamata; Liying Ge; Takashi Ueda; Yoshiko Kikuchi; Keiji Tanaka; Akihiko Nakano; Akio Toh-e
MOLECULAR BIOLOGY OF THE CELL, Feb. 2007, [Reviewed] - A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes
Jun Hamazaki; Shun-ichiro Iemura; Tohru Natsume; Hideki Yashiroda; Keiji Tanaka; Shigeo Murata
EMBO JOURNAL, Oct. 2006, [Reviewed] - 【ユビキチン-プロテアソーム系とオートファジー 作動機構と病態生理】ユビキチン-プロテアソーム系 プロテアソーム研究の最前線 プロテアソーム活性化因子の多様性
佐伯 泰; 八代田 英樹
蛋白質・核酸・酵素, Aug. 2006 - [Demystification of deubiquitinating enzyme].
Yashiroda H; Komatsu M
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Aug. 2006, [Reviewed] - [Diversity of proteasome activators].
Saeki Y; Yashiroda H
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Aug. 2006, [Reviewed] - Preparation of proteasomes
Keiji Tanaka; Hideki Yashiroda; Nobuyuki Tanahashi
Cell Biology, Four-Volume Set, 2006, [Reviewed] - A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes
Y Hirano; KB Hendil; H Yashiroda; S Iemura; R Nagane; Y Hioki; T Natsume; K Tanaka; S Murata
NATURE, Oct. 2005, [Reviewed] - Hub1 is an essential ubiquitin-like protein without functioning as a typical modifier in fission yeast
H Yashiroda; K Tanaka
GENES TO CELLS, Dec. 2004, [Reviewed] - But1 and But2 proteins bind to Uba3, a catalytic subunit of E1 for neddylation, in fission yeast
H Yashiroda; K Tanaka
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2003, [Reviewed] - The molecular chaperone Hsp90 plays a role in the assembly and maintenance of the 26S proteasome
J Imai; M Maruya; H Yashiroda; Yahara, I; K Tanaka
EMBO JOURNAL, Jul. 2003, [Reviewed] - Proteasomes and Molecular Chaperones Cellular Machinery Responsible for Folding and Destruction of Unfolded Proteins
Jun Imai; Hideki Yashiroda; Mikako Maruya; Ichiro Yahara; Keiji Tanaka
CELL CYCLE, 2003, [Reviewed] - Yeast Whi2 and Psr1-phosphatase form a complex and regulate STRE-mediated gene expression
D Kaida; H Yashiroda; A Toh-e; Y Kikuchi
GENES TO CELLS, Jun. 2002, [Reviewed] - Control of IkappaBalpha proteolysis by the ubiquitin-proteasome pathway.
Tanaka K; Kawakami T; Tateishi K; Yashiroda H; Chiba T
Biochimie, Mar. 2001, [Reviewed] - p57Kip2 Is Degraded through the Proteasome in Osteoblasts Stimulated to Proliferation by Transforming Growth Factor β1
Tomohiko Urano; Hideki Yashiroda; Masatoshi Muraoka; Kiyoko Tanaka; Takayuki Hosoi; Satoshi Inoue; Yasuyoshi Ouchi; Keiji Tanaka; Hideo Toyoshima
Journal of Biological Chemistry, Apr. 1999, [Reviewed] - The PY-motif of Bul1 protein is essential for growth of Saccharomyces cerevisiae under various stress conditions
Hideki Yashiroda; Daisuke Kaida; Akio Toh-e; Yoshiko Kikuchi
Gene, Dec. 1998, [Reviewed]
Lead - Isolation of a Tobacco cDNA Encoding Sar1 GTPase and Analysis of Its Dominant Mutations in Vesicular Traffic Using a Yeast Complementation System
Takeuchi M; Tada M; Saito C; Yashiroda H; Nakano A
Plant Cell Physiol, 1998 - Bul1, a new protein that binds to the Rsp5 ubiquitin ligase in Saccharomyces cerevisiae.
H Yashiroda; T Oguchi; Y Yasuda; A Toh-E; Y Kikuchi
Molecular and Cellular Biology, Jul. 1996, [Reviewed]
Lead
MISC
- Role of Vps34 in lipid-induced Ire1 activation
岩田紬; 山岸洸太; ZANG Xiuwen; 八代田英樹; 村田茂穂; 新井洋由; 河野望; 青木淳賢
日本薬学会年会要旨集(Web), 2023 - イノシトール欠乏時のIre1活性化に関わる脂質代謝酵素の探索
岩田紬; 山岸洸太; CHANG Hsiuwen; 八代田英樹; 村田茂穂; 新井洋由; 河野望; 青木淳賢
日本生化学会大会(Web), 2023 - 効率的なタンパク質合成にはリボソームタンパク質eS7がユビキチン化と脱ユビキチン化されることが重要である
八代田英樹; 竹原由香; 松尾芳隆; ZHAO Xian; 神垣あかね; 松崎哲郎; 小迫英尊; 稲田利文; 村田茂穂
日本生化学会大会(Web), 2022 - 出芽酵母20Sプロテアソーム形成に関わるシャペロン複合体Dmp1/Dmp2の立体構造解析
八代田 英樹; 水島 恒裕
細胞工学, Apr. 2008 - 【ユビキチン-プロテアソーム系とオートファジー 作動機構と病態生理】 ユビキチン-プロテアソーム系 ユビキチン修飾 神秘のベールを脱ぎ始めた脱ユビキチン化酵素
八代田 英樹; 小松 雅明
蛋白質・核酸・酵素, Aug. 2006 - Hub1 is an essential ubiquitin-like protein without functioning as a typical modifier in fission yeast
Hideki Yashiroda; Keii Tanaka
CELL STRUCTURE AND FUNCTION, May 2004 - Whi2 is required for general stress response in Saccharomyces cerevisiae.
D Kaida; H Yashiroda; A Toh-e; Y Kikuchi
YEAST, Aug. 2001 - The role of ubiquitin ligases in the cell proliferation
H. Yashiroda; Y. Kikuchi
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1997 - Sar1 GTPase required for ER-to-Golgitransport (2) -An approach using inducible dominant-lethalmutations in the tobacco BY-2 cells
TAKEUCHI Masaki; YASHIRODA Hideki; TAKAHASHI Yohsuke; NAGATA Toshiyuki; NAKANO Akihiko
Plant and cell physiology, Mar. 1995
Affiliated academic society
Research Themes
- Elucidation of the mechanism for the proteasome assembly regulated by
Grant-in-Aid for Scientific Research (C)
The University of Tokyo
01 Apr. 2016 - 31 Mar. 2019 - Why is the 26S proteasome essential for eukaryotic cell viability?
Grant-in-Aid for Scientific Research (C)
The University of Tokyo
01 Apr. 2012 - 31 Mar. 2015 - Studies on proteolysis mediated by the proteasomes and ubiquitin
Grant-in-Aid for Specially Promoted Research
Tokyo Metropolitan Organization for Medical Research
2001 - 2005 - Functional analysis of PML protein in the ubiquitin system
Grant-in-Aid for Scientific Research (C)
2001 - 2002
