Mikiko Takahashi
| Faculty of Pharmaceutical Sciences,Department of Pharmaceutical Sciences | Professor |
Last Updated :2025/06/19
■Researcher basic information
■Career
Career
- Oct. 2010 - Present
帝京平成大学, Faculty of Pharmaceutical Sciences, Professor - Apr. 2007 - Sep. 2010
Kobe University, Graduate School of Science Division of Biology and Faculty of Science Department of Biology, 講師（兼任） - Oct. 2005 - Sep. 2010
Kobe University, Biosignal Research Center, 講師 - Aug. 2000 - Sep. 2005
Kobe University, Biosignal Research Center, 助手 - Apr. 1997 - Jul. 2000
Kobe University, Biosignal Research Center, 非常勤講師 - Apr. 1983 - Mar. 1997
ヘキストジャパン（株）, 医薬総合研究所, 研究員
■Research activity information
Paper
- LRBA is essential for urinary concentration and body water homeostasis.
Yu Hara; Fumiaki Ando; Daisuke Oikawa; Koichiro Ichimura; Hideki Yanagawa; Yuriko Sakamaki; Azuma Nanamatsu; Tamami Fujiki; Shuichi Mori; Soichiro Suzuki; Naofumi Yui; Shintaro Mandai; Koichiro Susa; Takayasu Mori; Eisei Sohara; Tatemitsu Rai; Mikiko Takahashi; Sei Sasaki; Hiroyuki Kagechika; Fuminori Tokunaga; Shinichi Uchida
Proceedings of the National Academy of Sciences of the United States of America, 26 Jul. 2022, [Reviewed] - The Cep57-pericentrin module organizes PCM expansion and centriole engagement.
Koki Watanabe; Daisuke Takao; Kei K Ito; Mikiko Takahashi; Daiju Kitagawa
Nature communications, 25 Feb. 2019, [Reviewed] - Mutant analysis of Cdt1's function in suppressing nascent strand elongation during DNA replication in Xenopus egg extracts.
Yuta Nakazaki; Takashi Tsuyama; Yutaro Azuma; Mikiko Takahashi; Shusuke Tada
Biochemical and biophysical research communications, 02 Sep. 2017, [Reviewed] - CAMSAP3-dependent microtubule dynamics regulates Golgi assembly in epithelial cells.
Jing Wang; Honglin Xu; Yuqiang Jiang; Mikiko Takahashi; Masatoshi Takeichi; Wenxiang Meng
Journal of genetics and genomics = Yi chuan xue bao, 20 Jan. 2017, [Reviewed] - Excess Cdt1 inhibits nascent strand elongation by repressing the progression of replication forks in Xenopus egg extracts.
Yuta Nakazaki; Takashi Tsuyama; Masayuki Seki; Mikiko Takahashi; Takemi Enomoto; Shusuke Tada
Biochemical and biophysical research communications, 05 Feb. 2016, [Reviewed] - MTCL1 crosslinks and stabilizes non-centrosomal microtubules on the Golgi membrane.
Yoshinori Sato; Kenji Hayashi; Yoshiko Amano; Mikiko Takahashi; Shigenobu Yonemura; Ikuko Hayashi; Hiroko Hirose; Shigeo Ohno; Atsushi Suzuki
Nature communications, 04 Nov. 2014, [Reviewed] - More isn't always better: limiting centrosome size in interphase.
Mikiko Takahashi; Kazuhiko Matsuo
Cell cycle (Georgetown, Tex.), 15 May 2013
Corresponding - Kendrin is a novel substrate for separase involved in the licensing of centriole duplication.
Kazuhiko Matsuo; Keita Ohsumi; Mari Iwabuchi; Toshio Kawamata; Yoshitaka Ono; Mikiko Takahashi
Current biology : CB, 22 May 2012, [Reviewed]
Last, Corresponding - AKAP9 regulation of microtubule dynamics promotes Epac1-induced endothelial barrier properties.
Seema Sehrawat; Thomas Ernandez; Xavier Cullere; Mikiko Takahashi; Yoshitaka Ono; Yulia Komarova; Tanya N Mayadas
Blood, 13 Jan. 2011, [Reviewed] - Involvement of a centrosomal protein kendrin in the maintenance of centrosome cohesion by modulating Nek2A kinase activity.
Kazuhiko Matsuo; Tamako Nishimura; Akihide Hayakawa; Yoshitaka Ono; Mikiko Takahashi
Biochemical and biophysical research communications, 23 Jul. 2010, [Reviewed]
Last - Accumulation of tumor-suppressor PTEN in Alzheimer neurofibrillary tangles.
Yuma Sonoda; Hideyuki Mukai; Kazuhiko Matsuo; Mikiko Takahashi; Yoshitaka Ono; Kiyoshi Maeda; Haruhiko Akiyama; Toshio Kawamata
Neuroscience letters, 26 Feb. 2010, [Reviewed] - A peptidyl-prolyl isomerase, FKBP12, accumulates in Alzheimer neurofibrillary tangles.
Hisato Sugata; Kazuhiko Matsuo; Taisuke Nakagawa; Mikiko Takahashi; Hideyuki Mukai; Yoshitaka Ono; Kiyoshi Maeda; Haruhiko Akiyama; Toshio Kawamata
Neuroscience letters, 07 Aug. 2009, [Reviewed] - AMP-activated protein kinase phosphorylates Golgi-specific brefeldin A resistance factor 1 at Thr1337 to induce disassembly of Golgi apparatus.
Takafumi Miyamoto; Noriko Oshiro; Ken-ichi Yoshino; Akio Nakashima; Satoshi Eguchi; Mikiko Takahashi; Yoshitaka Ono; Ushio Kikkawa; Kazuyoshi Yonezawa
The Journal of biological chemistry, 15 Feb. 2008, [Reviewed] - Recruitment of CG-NAP to the Golgi apparatus through interaction with dynein-dynactin complex.
Hon-Song Kim; Mikiko Takahashi; Kazuhiko Matsuo; Yoshitaka Ono
Genes to cells : devoted to molecular & cellular mechanisms, Mar. 2007, [Reviewed] - Centrosome-targeting region of CG-NAP causes centrosome amplification by recruiting cyclin E-cdk2 complex.
Tamako Nishimura; Mikiko Takahashi; Hon-Song Kim; Hideyuki Mukai; Yoshitaka Ono
Genes to cells : devoted to molecular & cellular mechanisms, Jan. 2005, [Reviewed] - Protein kinase PKN1 associates with TRAF2 and is involved in TRAF2-NF-kappaB signaling pathway.
Yusuke Gotoh; Kumiko Oishi; Hideki Shibata; Akiko Yamagiwa; Takayuki Isagawa; Tamako Nishimura; Emiko Goyama; Mikiko Takahashi; Hideyuki Mukai; Yoshitaka Ono
Biochemical and biophysical research communications, 13 Feb. 2004, [Reviewed] - Regulation of a mitogen-activated protein kinase kinase kinase, MLTK by PKN.
Mikiko Takahashi; Yusuke Gotoh; Takayuki Isagawa; Tamako Nishimura; Emiko Goyama; Hon-Song Kim; Hideyuki Mukai; Yoshitaka Ono
Journal of biochemistry, Feb. 2003, [Reviewed]
Lead - Pulse-chase analysis of protein kinase C.
Mikiko Takahashi; Yoshitaka Ono
Methods in molecular biology (Clifton, N.J.), 2003, [Invited]
Lead - Centrosomal anchoring of the protein kinase CK1delta mediated by attachment to the large, coiled-coil scaffolding protein CG-NAP/AKAP450.
James E Sillibourne; Diane M Milne; Mikiko Takahashi; Yoshitaka Ono; David W Meek
Journal of molecular biology, 27 Sep. 2002, [Reviewed] - Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex.
Mikiko Takahashi; Akiko Yamagiwa; Tamako Nishimura; Hideyuki Mukai; Yoshitaka Ono
Molecular biology of the cell, Sep. 2002, [Reviewed]
Lead - PKN delays mitotic timing by inhibition of Cdc25C: possible involvement of PKN in the regulation of cell division.
Misaki K; Mukai H; Yoshinaga C; Oishi K; Isagawa T; Takahashi M; Ohsumi K; Kishimoto T; Ono Y
Proceedings of the National Academy of Sciences of the United States of America, Jan. 2001, [Reviewed] - Association of immature hypophosphorylated protein kinase cepsilon with an anchoring protein CG-NAP.
Takahashi M; Mukai H; Oishi K; Isagawa T; Ono Y
The Journal of biological chemistry, Nov. 2000, [Reviewed]
Lead - Identification and characterization of PKNbeta, a novel isoform of protein kinase PKN: expression and arachidonic acid dependency are different from those of PKNalpha.
Oishi K; Mukai H; Shibata H; Takahashi M; Ona Y
Biochemical and biophysical research communications, Aug. 1999, [Reviewed] - Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus.
Takahashi M; Shibata H; Shimakawa M; Miyamoto M; Mukai H; Ono Y
The Journal of biological chemistry, Jun. 1999, [Reviewed]
Lead - The role of PKN in the regulation of alphaB-crystallin expression via heat shock transcription factor 1.
Kitagawa M; Mukai H; Takahashi M; Ono Y
Biochemical and biophysical research communications, Nov. 1998, [Reviewed] - Proteolytic activation of PKN by caspase-3 or related protease during apoptosis.
Takahashi M; Mukai H; Toshimori M; Miyamoto M; Ono Y
Proceedings of the National Academy of Sciences of the United States of America, Sep. 1998, [Reviewed]
Lead
MISC
- Function of the centrosomal protein PCNT in aggresome formation
KIM Hongsong; 梅原千奈; 大場美嬉; 小林拓巨; 本田小波; 松尾和彦; 高橋美樹子
日本薬学会年会要旨集(Web), 2024 - CG-NAP/AKAP450はPCM1の細胞内局在を制御することで一次繊毛形成に寄与する
金憲誠; 会田紗也加; 赤江亮祐; 石原賢; 鷺飛鳥; 鈴木捺美; 高橋美樹子
日本分子生物学会年会プログラム・要旨集(Web), 2019 - Crosstalk between Shc and PKC signaling: The functional analysis of PKN in the p38 MAP kinase signaling.
小野功貴; 向井秀幸; 高橋美樹子
長寿命遺伝子としてのShcシグナリングに関する分子遺伝学的研究 平成14年度 総括・分担研究報告書, 2003 - アンカリング蛋白質CG-NAPの中心体における機能 微小管形成の開始点であるγ-チューブリンリング複合体(γTuRC)を中心体に繋ぎ止めている可能性について
高橋美樹子; 山際晶子; 西村珠子; 向井秀幸; 小野功貴
生化学, 2002
Research Themes
- CG-NAP function in ciliogenesis through regulation of centriolar satellite formation
Grant-in-Aid for Scientific Research (C)
Teikyo Heisei University
01 Apr. 2019 - 31 Mar. 2023 - Study of initiation process of the centrosome duplication.
Grant-in-Aid for Young Scientists (B)
01 Apr. 2013 - 31 Mar. 2016 - Functional analysis of separase and its novel substrate in the licensing of centrosome duplication
Grant-in-Aid for Scientific Research (C)
Teikyo Heisei University
2011 - 2013 - Pathological study for a protein anchoring tau kinases and tau phosphatases in Alzheimer brain tissues
Grant-in-Aid for Scientific Research (C)
Kobe University
2008 - 2010 - Research of signal transduction to neuronal degeneration mediated by tau-kinases complex in dementia
Grant-in-Aid for Scientific Research (C)
Kobe University
2006 - 2007 - Functional regulation of centrosome and Golgi apparatus by signal-anchoring proteins.
Grant-in-Aid for Scientific Research (B)
Kobe University
2005 - 2007 - Research of signal transduction to neuronal degeneration mediated by tau phorphorylation in dementia
Grant-in-Aid for Scientific Research (C)
Kobe University
2004 - 2005 - Functional Analysis of an Anchoring Protein CG-NAP in the Golgi Apparatus.
Grant-in-Aid for Scientific Research (C)
Kobe University
2003 - 2004 - Functional Analysis of an Anchoring Protein CG-NAP in the Centrosome
Grant-in-Aid for Scientific Research (C)
Biosignal Research Center, Kobe University
2001 - 2002
