Masakazu Ishii
| Faculty of Pharmaceutical Sciences,Department of Pharmaceutical Sciences | Professor |
| Graduate School of Pharmaceutical Sciences,Doctoral Program in Pharmaceutical Sciences | Professor |
Last Updated :2025/10/07
■Researcher basic information
■Career
Career
- Apr. 2018 - Present
Teikyo Heisei University, Faculty of Pharmaceutical Sciences - Apr. 2014 - Mar. 2018
Showa University, School of Pharmacy - Apr. 2006 - Mar. 2014
Showa University, School of Pharmacy, Pathophysiology - Aug. 2002 - Mar. 2006
Showa University, School of Pharmacy, Pathophysiology - Aug. 2001 - Jul. 2002
- Apr. 1998 - Jul. 2002
Showa University, School of Pharmacy, Clinical Pharmacy - Aug. 2000 - Jul. 2001
- Apr. 1994 - Mar. 1995
Teikyo University, School of Medicine
Educational Background
■Research activity information
Paper
- The current state of headache treatment and the involvement of pharmacists in treatment of people with chronic headache.
Masakazu Ishii; Hirotaka Katoh; Tamotsu Kijima; Ikumi Ito
BPB Reports, Dec. 2023, [Reviewed] - Investigation on Headache Caused by Weather and Atmospheric Pressure Changes and Use of Goreisan
Masakazu Ishii, Ikumi Ito, Hirotaka Katoh
Jun. 2023, [Reviewed] - 健康サポート薬局の待合室の光環境に関する調査 頭痛患者と光環境
Jun. 2023 - Survey on Headache During COVID-19 Infection in People with Chronic Headache
Masakazu Ishii; Ikumi Ito; Hirotaka Katoh
BPB Reports, Apr. 2023, [Reviewed] - Possible involvement of TRPM2 activation in 5-fluorouracil-induced myelosuppression in mice
Masaaki Ishibashi; Masakazu Ishii; Shinichiro Yamamoto; Yasuo Mori; Shunichi Shimizu
European Journal of Pharmacology, Jan. 2021 - Relationship between migraine and internet addiction in pharmacy students
Masakazu Ishii; Hirotaka Katoh; Hideyo Kasai; Masaaki Ishibashi
Japan Journal of Research, 30 Apr. 2020
Background: In recent years, with the rapid popularization of the Internet, lifestyle disturbances, such as insufficient sleep due to excessive use of the Internet, is of concern. Sleep problems are known to trigger migraines. To clarify the relationship between migraine and Internet addiction, a questionnaire survey was conducted for pharmacy students at university. Methods: Internet addiction symptoms were assessed using the Internet Addiction Test (IAT), and migraine was evaluated using modified Japanese migraine screening. Continuous variables were analysed using the unpaired Student’s t-test or one-way analysis of variance followed by multiple Turkey's comparison tests. Categorical variables were analysed by the χ2 test. Results: The recovery rate was 98.9% (442 / 447 students). Of the 288 students who had headaches in the past 3 months, 145 students (32.8%, 145/442 students) were judged as having migraines by migraine screening. Sleep problems (62.1%) were observed in the migraine group. Moreover, sleep deprivation due to headache was noted in 31.7% of the migraine group. The percentage of students with Internet addiction in the migraine group was significantly higher than that in the other headache group or no headache group. Conclusions: Internet addiction was associated with the presence/absence of migraine in pharmacy students at university - Therapeutic effects of intranasal sumatriptan for cluster headache
Masakazu Ishii; Hirotaka Katoh; Motoaki Imawaka; Hideyo Kasai; Masaaki Ishibashi
Yakugaku Zasshi, 2019 - Therapeutic Effects of Intranasal Sumatriptan for Cluster Headache
Masakazu Ishii; Hirotaka Katoh; Motoaki Imawaka; Hideyo Kasai; Masaaki Ishibashi
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Jan. 2019 - [Therapeutic Effects of Intranasal Sumatriptan for Cluster Headache].
Masakazu Ishii; Hirotaka Katoh; Motoaki Imawaka; Hideyo Kasai; Masaaki Ishibashi
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2019
To clarify the associated factors for negative response to sumatriptan nasal spray in patients with cluster headache, we investigated the involvement of clinical information, such as the characteristics of headaches, before commencing sumatriptan nasal spray treatment. There were 18 male patients and 4 female patients. A total of 17 responders and 5 non-responders to sumatriptan nasal spray participated in the present study. Three factors for negative response to sumatriptan nasal spray, "young age of onset", "psychiatric disorder", and "the headache is not in the orbit," were found. Oxygen inhalation and/or subcutaneous injection were effective for nonresponsive cases. Therefore, these factors are considered to be useful for predicting therapy before applying sumatriptan nasal spray. - Negative predictors of clinical response to amitriptyline in Japanese patients with migraine
Yuika Naito; Masakazu Ishii; Masaaki Ishibashi; Hideyo Kasai; Hirotaka Katoh
Neurology and Clinical Neuroscience, Sep. 2018, [Reviewed] - 薬学生を対象とした頭痛に対する理解と対応状況に関する調査
Apr. 2018 - Lack of association between TRP gene polymorphisms and complication of medication overuse headache in migraine patients.
J. Med. Clin. Res. Rev., 2018, [Reviewed] - A questionnaire survey on cooperation between community pharmacies and hospitals in outpatient chemotherapy - Comparison of roles of pharmacists in community pharmacy and hospitals
Masaaki Ishibashi; Masakazu Ishii; Miku Nagano; Yuji Kiuchi; Sanju Iwamoto
Yakugaku Zasshi, 2018, [Reviewed] - 薬局薬剤師における生活習慣と頭痛の実態調査
2018, [Reviewed] - 薬学生における片頭痛の学業への影響
2018, [Reviewed] - 5-FU誘導骨髄抑制におけるTRPM2チャネルの機能
Aug. 2017 - 頭痛医療における保険薬局薬剤師の役割に関する調査 2008年調査との比較
Mar. 2017 - Effect of clonazepam and clonidine on primary sleep bruxism: a double-blind, crossover, placebo-controlled trial
Takuro Sakai; Takafumi Kato; Shuichiro Yoshizawa; Takeshi Suganuma; Masayuk I. Takaba; Yasuhiro Ono; Ayako Yoshizawa; Yuya Yoshida; Tatsuya Kurihara; Masakazu Ishii; Fusae Kawana; Yuji Kiuchi; Kazuyoshi Baba
JOURNAL OF SLEEP RESEARCH, Feb. 2017, [Reviewed] - 保険薬局薬剤師の禁煙支援業務に関する調査研究：患者の視点から
2017, [Reviewed] - Efforts by Pharmacists in Community Pharmacy in Peacetime for Headache Medical Care in Emergencies, Such as Great Earthquake and Disaster
Masakazu Ishii; Hirotaka Katoh; Masaaki Ishibashi; Mizuki Ichikawa; Shinji Kurokawa; Setsuro Tsukada; Hideyo Kasai; Yuji Kiuchi; Sanju Iwamoto
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Nov. 2016, [Reviewed] - Clinical Response to Valproate in Patients with Migraine
Mizuki Ichikawa; Hirotaka Katoh; Tatsuya Kurihara; Masakazu Ishii
JOURNAL OF CLINICAL NEUROLOGY, Oct. 2016, [Reviewed] - TRPM2 channels in alveolar epithelial cells mediate bleomycin-induced lung inflammation
Ryo Yonezawa; Shinichiro Yamamoto; Miki Takenaka; Yukiko Kage; Takaharu Negoro; Takahiro Toda; Masayuki Ohbayashi; Tomohiro Numata; Yasuko Nakano; Toshinori Yamamoto; Yasuo Mori; Masakazu Ishii; Shunichi Shimizu
FREE RADICAL BIOLOGY AND MEDICINE, Jan. 2016, [Reviewed] - Chemotherapy-induced neutropenia as a prognostic factor in patients with unresectable pancreatic cancer
Tatsuya Kurihara; Mari Kogo; Masakazu Ishii; Ken Shimada; Keiichiro Yoneyama; Katsuya Kitamura; Shunichi Shimizu; Hitoshi Yoshida; Yuji Kiuchi
CANCER CHEMOTHERAPY AND PHARMACOLOGY, Dec. 2015, [Reviewed] - Sensitization of H2O2-induced TRPM2 activation and subsequent interleukin-8 (CXCL8) production by intracellular Fe2+ in human monocytic U937 cells
Shunichi Shimizu; Ryo Yonezawa; Takaharu Negoro; Shinichiro Yamamoto; Tomohiro Numata; Masakazu Ishii; Yasuo Mori; Takahiro Toda
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, Nov. 2015, [Reviewed] - Practical Prognostic Index for Survival in Patients with Unresectable Pancreatic Cancer treated with Gemcitabine or S-1
Tatsuya Kurihara; Mari Kogo; Masakazu Ishii; Keiichiro Yoneyama; Katsuya Kitamura; Ken Shimada; Shunichi Shimizu; Hitoshi Yoshida; Yuji Kiuchi
HEPATO-GASTROENTEROLOGY, Mar. 2015, [Reviewed] - Lack of association between CGRP-related gene polymorphisms and medication overuse headache in migraine patients.
Ishii M; Katoh H; Kurihara T; Saguchi K; Shimizu S, Kawamura
Integr. Mol. Med., 2015, [Reviewed] - Catechol-O-methyl transferase gene polymorphisms in Japanese patients with medication overuse headache.
Ishii M; Katoh H; Kurihara T; Saguchi K; Shimizu S; Kawamura M
JSM Genet. Genomics., 2015, [Reviewed] - Orexin receptor gene polymorphisms in Japanese migraine patients with medication overuse headache.
Ishii M; Ishibashi M; Katoh H
J. J. Neur. Neurosci., 2015, [Reviewed] - A cyclooxygenase 2 gene polymorphism is a risk factor for the complication of medication overuse headaches in patients with migraines.
Ishii M; Katoh H; Kurihara T; Saguchi K; Miyasaka Y; Shimizu S; Kawamura M
J. Neurol. Disord., 2015, [Reviewed] - Antioxidant enzyme gene polymorphisms in Japanese migraine patients with medication overuse headache.
Ishii M; Hirano T; Katoh H
Int. J. Neurol. Res., 2015, [Reviewed] - 保険薬局薬剤師に期待される禁煙支援業務に関する調査研究
2015, [Reviewed] - Inhibitory effects of AG490 on H2O2-induced TRPM2-mediated Ca2+ entry
Shunichi Shimizu; Ryo Yonezawa; Tamio Hagiwara; Takashi Yoshida; Nobuaki Takahashi; Satoshi Hamano; Takaharu Negoro; Takahiro Toda; Minoru Wakamori; Yasuo Mori; Masakazu Ishii
EUROPEAN JOURNAL OF PHARMACOLOGY, Nov. 2014, [Reviewed] - Polymorphisms of nitric oxide synthase and GTP cyclohydrolase I genes in Japanese patients with medication overuse headaches
Masakazu Ishii; Mirei Yahara; Hirotaka Katoh; Mitsuru Kawamura; Shunichi Shimizu
NEUROLOGY ASIA, Sep. 2014, [Reviewed] - クロナゼパム、クロニジンを用いた睡眠時ブラキシズムに対する薬剤効果について 二重盲検ランダム化比較試験
Jul. 2014 - 睡眠時ブラキシズムに対する薬剤効果についての二重盲検ランダム化比較試験
May 2014 - Involvement of TRPM2 and L-type Ca2+ channels in Ca2+ entry and cell death induced by hydrogen peroxide in rat beta-cell line RIN-5F
Masakazu Ishii; Tamio Hagiwara; Yasuo Mori; Shunichi Shimizu
JOURNAL OF TOXICOLOGICAL SCIENCES, Apr. 2014, [Reviewed] - 片頭痛患者におけるバルプロ酸の抵抗性予測モデルの構築
Mar. 2014 - ブレオマイシンによる肺の炎症におけるTRPM2チャネルの役割
Mar. 2014 - MAOA and TNF-beta gene polymorphisms are associated with photophobia but not osmophobia in patients with migraine.
Ishii M; Usami S; Hara H; Imagawa A; Masuda Y; Shimizu S
Acta Neurol. Taiwan., 2014, [Reviewed] - Influence of the Tohoku-Pacific Ocean Earthquake and Its Aftershocks on the Response to Prophylactic Therapy with Lomerizine in Patients with Migraine in Tokyo: A Retrospective Study
Masakazu Ishii; Hirotaka Katoh; Maho Takagi; Mitsuru Kawamura; Shunichi Shimizu
EUROPEAN NEUROLOGY, 2014, [Reviewed] - Characteristics of inconsistent responders to prophylaxis therapy with lomerizine in patients with migraine: A retrospective study in Japan
Masakazu Ishii; Hirotaka Katoh; Tatsuya Kurihara; Mitsuru Kawamura; Shunichi Shimizu
JOURNAL OF THE NEUROLOGICAL SCIENCES, Dec. 2013, [Reviewed] - MAOA、MTHFR、TNF-βの多型性は片頭痛の病態に関与する独立した因子である
Dec. 2013, [Reviewed] - Prediction and structural equation model of sertraline treatment response in Japanese patients with major depressive disorder
Gentaro Nishioka; Hideaki Yashima; Yuji Kiuchi; Sumiko Nakamura; Hideto Oyamada; Masakazu Ishii; Ikuo Kudo
Human Psychopharmacology, Nov. 2013, [Reviewed] - 睡眠時ブラキシズム患者の睡眠構築について(The Relationship Between Sleep Bruxism and Sleep Architecture)
葭澤 秀一郎; 加藤 隆史; 川名 ふさ江; 酒井 拓郎; 吉澤 亜矢子; 小野 康寛; 高場 雅之; 栗原 竜也; 石井 正和; 菅沼 岳史; 木内 祐二; 馬場 一美
Dental Medicine Research, Mar. 2013 - 片頭痛患者におけるロメリジンの反応性予測モデルの構築
Mar. 2013 - Decreased cardiac mitochondrial tetrahydrobiopterin in a rat model of pressure overload
Shunichi Shimizu; Masaaki Ishibashi; Sumito Kumagai; Teruaki Wajima; Toshihito Hiroi; Tatsuya Kurihara; Masakazu Ishii; Yuji Kiuchi
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, Mar. 2013, [Reviewed] - Neutrophil TRPM2 channels are implicated in the exacerbation of myocardial ischaemia/reperfusion injury
Toshihito Hiroi; Teruaki Wajima; Takaharu Negoro; Masakazu Ishii; Yasuko Nakano; Yuji Kiuchi; Yasuo Mori; Shunichi Shimizu
CARDIOVASCULAR RESEARCH, Feb. 2013, [Reviewed] - Predictive index for the onset of medication overuse headache in migraine patients
T. Onaya; M. Ishii; H. Katoh; S. Shimizu; H. Kasai; M. Kawamura; Y. Kiuchi
Neurological Sciences, Jan. 2013, [Reviewed] - Tryptophan hydroxylase 2 gene polymorphisms in Japanese patients with medication overuse headaches
Masakazu Ishii; Hirotaka Katoh; Tomomi Onaya; Hideyo Kasai; Mitsuru Kawamura; Shunichi Shimizu
Acta Neurologica Taiwanica, 2013, [Reviewed] - Association between the G252A Tumor Necrosis Factor-β Gene Polymorphism and Medication-Overuse Headache.
Ishii M; Onaya T; Katoh H; Kiuchi Y; Kasai H; Kawamura M; Shimizu S
Journal of clinical neurology (Seoul, Korea), Dec. 2012, [Reviewed] - Association of genetic, psychological and behavioral factors with sleep bruxism in a Japanese population
Yuka Abe; Takeshi Suganuma; Masakazu Ishii; Gou Yamamoto; Tomohiko Gunji; Glenn T. Clark; Tetsuhiko Tachikawa; Yuji Kiuchi; Yoshimasa Igarashi; Kazuyoshi Baba
JOURNAL OF SLEEP RESEARCH, Jun. 2012, [Reviewed] - Negative predictors of clinical response to triptans in patients with migraine
M. Ishii; Y. Sakairi; H. Hara; A. Imagawa; S. Shimizu; J. Takahashi; A. Nagamine; Y. Naito; Y. Masuda; S. Usami; Y. Kiuchi
NEUROLOGICAL SCIENCES, Apr. 2012, [Reviewed] - MAOA, MTHFR, and TNF-beta genes polymorphisms and personality traits in the pathogenesis of migraine
Masakazu Ishii; Shunichi Shimizu; Yuki Sakairi; Ayumu Nagamine; Yuika Naito; Yukiko Hosaka; Yuko Naito; Tatsuya Kurihara; Tomomi Onaya; Hideto Oyamada; Atsuko Imagawa; Kenji Shida; Johji Takahashi; Katsuji Oguchi; Yutaka Masuda; Hajime Hara; Shino Usami; Yuji Kiuchi
MOLECULAR AND CELLULAR BIOCHEMISTRY, Apr. 2012, [Reviewed] - Possible Involvement of Transient Receptor Potential Channels in Electrophile-Induced Insulin Secretion from RINm5F Cells
Satoshi Numazawa; Makiko Takase; Tomomi Ahiko; Masakazu Ishii; Shun-ichi Shimizu; Takemi Yoshida
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Mar. 2012, [Reviewed] - Inhibitory effect of Jak2 inhibitor AG490 on H2O2-induced Ca2+ entry via TRPM2 channels
Hitomi Takashima; Masakazu Ishii; Kazunori Akimoto; Yasuo Mori; Shunichi Shimizu
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012, [Reviewed] - Neuroprotection by lomerizine, a prophylactic drug for migraine, against hydrogen peroxide-induced hippocampal neurotoxicity
Masakazu Ishii; Ryouta Iizuka; Yuji Kiuchi; Yasuo Mori; Shunichi Shimizu
MOLECULAR AND CELLULAR BIOCHEMISTRY, Dec. 2011, [Reviewed] - がん性疼痛に対するオピオイド抵抗性に寄与する要因の検討
Jun. 2011 - Presynaptic stimulus-release and postsynaptic compensatory changes in mice lacking the N-type calcium channel alpha(1B)-subunit
Natalia N. Petrashevskaya; Masakazu Ishii; Karen D'Souza; Sheryl E. Koch; Geraldine A. Fuller-Bicer; Arnold Schwartz
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, Feb. 2011, [Reviewed] - 片頭痛スクリーナーを用いた女性片頭痛患者の随伴症状の解析
2011, [Reviewed] - Impaired Ca2+ Regulation of CD4(+)CD25(+) Regulatory T Cells from Pediatric Asthma
Yoshiki Yamamoto; Takaharu Negoro; Akane Hoshi; Akiko Wakagi; Shunichi Shimizu; Alison H. Banham; Masakazu Ishii; Haruyo Akiyama; Yuji Kiuchi; Susumu Sunaga; Takashi Tobe; Giovanna Roncador; Kazuo Itabashi; Yasuko Nakano
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2011, [Reviewed] - Conservative, Not Surgical, Treatment Should Be Recommended for All Unruptured Aneurysms
USAMI Shino; NAGAMINE Ayumu; ISHII Masakazu; OGUCHI Katsuji; KIUCHI Yuji
Health Evaluation and Promotion, 15 Nov. 2010
Calculation of rupture risk by multivariate analysis. Stable unruptured aneurysms should be treated conservatively, not with surgical treatment. Reasons why I take this position are listed in the following. 1. If carefully observed with findings from three-dimensional CT combined with endoscopic examination, aneurysms likely or unlikely to be ruptured can be distinguished. The latter do not need surgical operation, as the rupture risk is low. 2. Endovascular surgery is at present in the transition stage, and my clinic would like to introduce an internal neck clipping coil (which we call iCLIP) or stent (iSTENT) (Fig. 2) to patients from now on rather than undergoing the conventional microcoil embolization procedure mainly with GDC. We explain to the patients whose aneurysm is unlikely to rupture, that elective therapy is better. Only after the aneurysm is found to be steadily enlarging and the risk of rupture is high, conventional or the endovascular procedure with the lowest risk at that stage should be selected. 3. The most important thing is to find factors associated with the rupture, enlargement or de novo aneurysm formation. We found these factors can be found by multivariate analysis. Multivariate analysis will disentwine the confounding situation, gradually revealing the true risk factors. Conventional multivariate analysis needs a large number of cases experienced in our clinic, but we conducted a kind of "virtual" multivariate analysis by borrowing data in foreign medical articles. The validity of this procedure is still to be tested, but patients in a small-sized clinic with a small number of unruptured aneurysm cases may understand what kind of risk they have and what to do to lower the risk of rupture. This procedure of working up statistics using "virtual" data has never been done, and I would welcome any discussion to prove its validity. As stated above, by our "virtual" multivariate analysis, risk prediction of aneurysm rupture became possible, and we concluded that the conservative treatment should be the first choice for the treatment of unruptured aneurysms. - Association of the A-1438G Polymorphism in Serotonin 2A Receptor in Migraine with Aura among Japanese Patients
Yuika Naito; Masakazu Ishii; Ayumu Nagamine; Atsuko Imagawa; Kenji Shida; Johji Takahashi; Yukiko Hosaka; Yuko Naito; Hideto Oyamada; Shunichi Shimizu; Katsuji Oguchi; Hajime Hara; Yutaka Masuda; Shino Usami; Yuji Kiuchi
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Oct. 2010, [Reviewed] - Is a Migraine Screener Useful for Pharmacists in Community Pharmacy to Distinguish Patients with Migraine?
Masakazu Ishii; Ayumu Nagamine; Yuka Kimura; Atsuko Imagawa; Johji Takahashi; Hajime Hara; Yutaka Masuda; Shino Usami; Yuji Kiuchi
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Jun. 2010, [Reviewed] - 多変量解析を用いた女性の片頭痛発症に関与する遺伝子多型と性格特性の研究
Mar. 2010, [Reviewed] - 頭痛患者のセルフメディケーションにおける登録販売者の役割 薬剤師の視点から見た登録販売者に対する教育制度導入の必要性
Mar. 2010, [Reviewed] - Inhibitory effect of lomerizine, a prophylactic drug for migraine, on H2O2-induced Ca2+ influx in cultured hippocampal neurons
Ryota Iizuka; Masakazu Ishii; Yasuo Mori; Yuji Kiuchi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010 - Inhibitory Effect of Lomerizine, a Prophylactic Drug for Migraines, on Serotonin-Induced Contraction of the Basilar Artery
Masakazu Ishii; Shunsuke Kobayashi; Masamichi Ohkura; Ryuichi Yamamoto; Shunichi Shimizu; Yuji Kiuchi
JOURNAL OF PHARMACOLOGICAL SCIENCES, Oct. 2009, [Reviewed] - Targeted disruption of the voltage-dependent calcium channel alpha(2)/delta-1-subunit
Geraldine A. Fuller-Bicer; Gyula Varadi; Sheryl E. Koch; Masakazu Ishii; Ilona Bodi; Nijiat Kadeer; James N. Muth; Gabor Mikala; Natalia N. Petrashevskaya; Michael A. Jordan; Sui-Po Zhang; Ning Qin; Christopher M. Flores; Idit Isaacsohn; Maria Varadi; Yasuo Mori; W. Keith Jones; Arnold Schwartz
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Jul. 2009, [Reviewed] - The Role of Pharmacists in a Community Pharmacy for Self-Medication of Patients with Headache
Yuika Naito; Masakazu Ishii; Keiji Kawana; Yuki Sakairi; Shunichi Shimizu; Yuji Kiuchi
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Jun. 2009, [Reviewed] - The Need for Collaboration between Community Pharmacies and Hospitals or Clinics in Providing Medical Treatment for Patients with Headache
Yuika Naito; Masakazu Ishii; Yuki Sakairi; Keiji Kawana; Shunichi Shimizu; Yuji Kiuchi
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Jun. 2009, [Reviewed] - Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound
Shigeki Kiyonaka; Kenta Kato; Motohiro Nishida; Kazuhiro Mio; Takuro Numaga; Yuichi Sawaguchi; Takashi Yoshida; Minoru Wakamori; Emiko Mori; Tomohiro Numata; Masakazu Ishii; Hiroki Takemoto; Akio Ojida; Kenta Watanabe; Aya Uemura; Hitoshi Kurose; Takashi Morii; Tsutomu Kobayashi; Yoji Sato; Chikara Sato; Itaru Hamachi; Yasuo Mori
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Mar. 2009, [Reviewed] - 頭痛医療における保険薬局と病院・診療所との医療連携の必要性
2009, [Reviewed] - 頭痛患者のセルフメディケーションにおける保険薬局薬剤師の役割
2009, [Reviewed] - Inhibitory effect of Jaks inhibitor AG490 on hydrogen peroxide-induced activation of TRPM2 channels
Yuko Kakihana; Yuji Kaneko; Tarnio Hagiwara; Masakazu Ishii; Shinichiro Yamamoto; Takashi Yoshida; Toshihito Hiroi; Yasuo Mori; Yuji Kiuchi; Shunichi Shimizu
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009, [Reviewed] - Involvement of TRPM2 channels in the early vascular permeability induced by acetic acid and zymosan
Yuji Kaneko; Yuko Kakihana; Toshihito Hiroi; Takaharu Negoro; Disuke Kamei; Masakazu Ishii; Yuji Kiuchi; Yasuo Mori; Shunichi Shimizu
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009, [Reviewed] - アドレナリン自己注射製剤の学校対応における学校薬剤師の役割
2009, [Reviewed] - 学校保健における学校薬剤師の役割：薬に関する指導・助言および薬教育活動
2009, [Reviewed] - Insulin Secretion in Response to L-Arginine under Decreasing Tetrahydrobiopterin Content
Masakazu Ishii; Shunichi Shimizu; Tatsuya Watabe; Yuji Kiuchi
PTERIDINES, Dec. 2008, [Reviewed] - Role of school pharmacist on safe handling of adrenaline auto-injector in school
Japanese journal of pediatrics, 2008, [Reviewed] - 薬学部における救命救急医療教育の必要性 ～保険薬局薬剤師の救命救急医療における役割～
2008, [Reviewed] - Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through activation of the Jak2 tyrosine kinase pathway in vascular endothelial cells
Shunichi Shimizu; Toshihito Hiroi; Masakazu Ishii; Tamio Hagiwara; Teruaki Wajima; Akira Miyazaki; Yuji Kiuchi
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2008, [Reviewed] - Facilitation of H2O2-induced A172 human glioblastoma cell death by insertion of oxidative stress-sensitive TRPM2 channels
Masakazu Ishii; Akinori Oyama; Tamio Hagiwara; Akira Miyazaki; Yasuo Mori; Yuji Kiuchi; Shunichi Shimizu
ANTICANCER RESEARCH, Nov. 2007, [Reviewed] - 養護教諭からみた学校薬剤師の現状と今後の課題～アンケート調査報告～
2007, [Reviewed] - Influence of SNPs in cytokine-related genes on the severity of food allergy and atopic eczema in children
Takaharu Negoro; Kanami Orihara; Tomoko Irahara; Hiroshi Nishiyama; Kanae Hagiwara; Risa Nishida; Hiroki Takagi; Kazue Satoh; Yoshiki Yamamoto; Shunichi Shimizu; Tamio Hagiwara; Masakazu Ishii; Toshihiro Tanioka; Yasuko Nakano; Ken Takeda; Isao Yoshimura; Yoji Iikura; Takashi Tobe
PEDIATRIC ALLERGY AND IMMUNOLOGY, Dec. 2006, [Reviewed] - Tetrahydrobiopterin regulates L-tyrosine-induced elevation of cytosolic calcium concentration in insulin-secreting cells
Masakazu Ishii; Shunichi Shimizu; Tatsuya Watabe; Yuji Kiuchi
PTERIDINES, Sep. 2006, [Reviewed] - Extracellular-added ADP-ribose increases intracellular free Ca2+ concentration through Ca2+ release from stores, but not through TRPM2-mediated Ca2+ entry, in rat beta-cell line RIN-5F
M Ishii; S Shimizu; T Hagiwara; T Wajima; A Miyazaki; Y Mori; Y Kiuchi
JOURNAL OF PHARMACOLOGICAL SCIENCES, Jun. 2006, [Reviewed] - Intracellular-produced hydroxyl radical mediates H2O2-induced Ca2+ influx and cell death in rat beta-cell line RIN-5F
M Ishii; S Shimizu; Y Hara; T Hagiwara; A Miyazaki; Y Mori; Y Kiuchi
CELL CALCIUM, Jun. 2006, [Reviewed] - Beneficial role of tetrahydrobiopterin on various cardiovascular diseases and regulation of its levels under pathological conditions
S Shimizu; M Ishii; T Wajima; T Hagiwara; T Negorol
PTERIDINES, Mar. 2006, [Reviewed] - Reduction of myocardial infarct size by tetra hyd robiopterin: Possible involvement of mitochondrial K-ATP channels activation through nitric oxide production
TI Wajima; S Shimizu; T Hiroi; M Ishii; Y Kiuchi
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, Feb. 2006, [Reviewed] - Inhibitory effect of lomerizine on TRP channel-mediated calcium influx
M Ishii; S Shimizu; Y Mori; Y Kiuchi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006 - Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells
S Shimizu; T Yoshida; M Wakamori; M Ishii; T Okada; M Takahashi; M Seto; K Sakurada; Y Kiuchi; Y Mori
JOURNAL OF PHYSIOLOGY-LONDON, Jan. 2006, [Reviewed] - Possible involvement of hydroxyl radical on the stimulation of tetrahydrobiopterin synthesis by hydrogen peroxide and peroxynitrite in vascular endothelial cells
S Shimizu; M Ishii; Y Miyasaka; T Wajima; T Negoro; T Hagiwara; Y Kiuchi
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, Apr. 2005, [Reviewed] - 小児気管支喘息患児末梢血中の制御性T細胞の検討
Mar. 2005 - Reduction of GTP cyclohydrolase I feedback regulating protein expression by hydrogen peroxide in vascular endothelial cells
M Ishii; S Shimizu; T Wajima; T Hagiwara; T Negoro; A Miyazaki; T Tobe; Y Kiuchi
JOURNAL OF PHARMACOLOGICAL SCIENCES, Feb. 2005, [Reviewed] - 三薬連携の現状と将来への展望に関する全国アンケート調査
2004, [Reviewed] - Decrease in tetrahydrobiopterin content promotes L-arginine-induced elevation of cytosolic calcium concentration in insulin-secreting cells
T Watabe; M Ishii; Y Mori; S Shimizu; Y Kiuchi
PTERIDINES, Dec. 2003, [Reviewed] - Stimulation of tetrahydrobiopterin synthesis by peroxynitrite in vascular endothelial cells
S Shimizu; M Ishii; Y Miyasaka; Y Kiuchi
PTERIDINES, Dec. 2003, [Reviewed] - Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through the induction of GTP-cyclohydrolase I and increases nitric oxidesynthase activity in vascular endothelial cells
S Shimizu; K Shiota; S Yamamoto; Y Miyasaka; M Ishii; T Watabe; M Nishida; Y Mori; T Yamamoto; Y Kiuchi
FREE RADICAL BIOLOGY AND MEDICINE, May 2003, [Reviewed] - Stimulation of tetrahydrobioptenin synthesis by basic fibroblast growth factor in vascular endothelial cells
S Shimizu; Y Miyasaka; S Yamamoto; M Ishii; Y Kiuchi
PTERIDINES, Mar. 2003, [Reviewed] - Stimulation of tetrahydrobiopterin synthesis by cyclosporin A during lipopolysaccharide treatment in vascular endothelial cells
M Ishii; S Shimizu; K Shiota; S Yamamoto; Y Kiuchi; T Yamamoto
PTERIDINES, Sep. 2002, [Reviewed] - Stimulation of tetrahydrobiopterin synthesis by cyclosporin A in mouse brain microvascular endothelial cells
M Ishii; S Shimizu; K Shiota; S Yamamoto; Y Kiuchi; T Yamamoto
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, Sep. 2002, [Reviewed] - Ca2+ channel alpha(1B) subunit (Ca-V 2.2) knockout mouse reveals a predominant role of N-type channels in the sympathetic regulation of the circulatory system
Y Mori; M Nishida; S Shimizu; M Ishii; T Yoshinaga; M Ino; K Sawada; T Niidome
TRENDS IN CARDIOVASCULAR MEDICINE, Aug. 2002, [Reviewed] - Hydrogen peroxide stimulates the LPS-induced tetrahydrobiopterin synthesis in mouse brain microvascular endothelial cells
K Shiota; S Shimizu; M Ishii; S Yamamoto; M Iwasaki; T Yamamoto; Y Kiuchi
PTERIDINES, Mar. 2002, [Reviewed] - LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death
Y Hara; M Wakamori; M Ishii; E Maeno; M Nishida; T Yoshida; H Yamada; S Shimizu; E Mori; J Kudoh; N Shimizu; H Kurose; Y Okada; K Imoto; Y Mori
MOLECULAR CELL, Jan. 2002, [Reviewed] - Possible role of BH4 as one of the cell defense system against reactive oxygen species-induced toxicity.
Ishii M; Shimizu S; Yamamoto T; Kiuchi Y
Recent Res. Devel. Life Sci., 2002, [Reviewed] - Dissecting receptor-mediated Ca2+ influx pathways: TRP channels and their native counterparts
Y Mori; R Inoue; M Ishii; Y Hara; K Imoto
JAPANESE JOURNAL OF PHARMACOLOGY, Dec. 2001, [Reviewed] - Negative regulation of insulin-induced tetrahydrobiopterin synthesis by protein kinase C in vascular endothelial cells
M Ishii; S Shimizu; T Nagai; S Kazuhiro; Y Kiuchi; T Yamamoto
PTERIDINES, Dec. 2001, [Reviewed] - Carboxy-PTIO increases the tetrahydrobiopterin level in mouse brain microvascular endothelial cells
S Shimizu; M Ishii; M Iwasaki; K Shiota; T Yamamoto; Y Kiuchi
JAPANESE JOURNAL OF PHARMACOLOGY, Sep. 2001, [Reviewed] - Stimulation of tetrahydrobiopterin synthesis induced by insulin: possible involvement of phosphatidylinositol 3-kinase
M Ishii; S Shimizu; T Nagai; K Shiota; Y Kiuchi; T Yamamoto
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, Jan. 2001, [Reviewed] - Troglitazone stimulates the insulin-induced tetrahydrobiopterin synthesis in vascular endothelial cells
M Ishii; S Shimizu; K Shiota; Y Kiuchi; T Yamamoto
PTERIDINES, Dec. 2000, [Reviewed] - Stimulation of tetrahydrobiopterin synthesis by 17 beta-estradiol in brain microvascular endothelial cells
K Shiota; M Ishii; T Yamamoto; S Shimizu; Y Kiuchi
PTERIDINES, Dec. 2000, [Reviewed] - Involvement of reactive oxygen species and nitric oxide in gastric ischemia-reperfusion injury in rats - Protective effect of tetrahydrobiopterin
M Ishii; S Shimizu; S Nawata; Y Kiuchi; T Yamamoto
DIGESTIVE DISEASES AND SCIENCES, Jan. 2000, [Reviewed] - Insulin stimulates tetrahydrobiopterin synthesis in mouse brain microvascular endothelial cells
M Ishii; S Shimizu; T Nagai; Y Kiuchi; T Yamamoto
PTERIDINES, Dec. 1999, [Reviewed] - Presence of excess tetrahydrobiopterin during nitric oxide production from inducible nitric oxide synthase in LPS-treated rat aorta
S Shimizu; M Ishii; Y Kawakami; Y Kiuchi; K Momose; T Yamamoto
LIFE SCIENCES, Nov. 1999, [Reviewed] - Stimulation of in vitro angiogenesis by tetrahydrobiopterin in bovine aortic endothelial cells
S Shimizu; M Yasuda; M Ishii; T Nagai; Y Kiuchi; T Yamamoto
JAPANESE JOURNAL OF PHARMACOLOGY, Jun. 1999, [Reviewed] - Characterization of the protective effect of tetrahydrobiopterin against S-nitroso-N-acetyl-D,L-penicillamine induced endothelial cell injury
M Ishii; S Shimizu; K Momose; Y Kiuchi; T Yamamoto
PTERIDINES, Mar. 1999, [Reviewed] - SIN-1-induced cytotoxicity in cultured endothelial cells involves reactive oxygen species and nitric oxide: Protective effect of sepiapterin
M Ishii; S Shimizu; K Momose; T Yamamoto
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, Feb. 1999, [Reviewed] - Role of tetrahydrobiopterin in the function of nitric oxide synthase, and its cytoprotective effect (Review)
S Shimizu; M Ishii; K Momose; T Yamamoto
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, Nov. 1998, [Reviewed] - Protective effects of tetrahydrobiopterin against nitric oxide-induced endothelial cell death
S Shimizu; M Ishii; Y Kawakami; K Momose; T Yamamoto
LIFE SCIENCES, Sep. 1998, [Reviewed] - Reduction by tetrahydrobiopterin of H2O2-induced endothelial cell injury
M Ishii; S Shimizu; K Momose; T Yamamoto
PHARMACOLOGY & TOXICOLOGY, Jun. 1998, [Reviewed] - Changes in nitric oxide synthase activity during exposure to hydrogen peroxide in cultured endothelial cells
S Shimizu; M Nomoto; M Ishii; S Naito; T Yamamoto; K Momose
RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY, Sep. 1997, [Reviewed] - Acceleration of oxidative stress-induced endothelial cell death by nitric oxide synthase dysfunction accompanied with decrease in tetrahydrobiopterin content
M Ishii; S Shimizu; T Yamamoto; K Momose; Y Kuroiwa
LIFE SCIENCES, Jul. 1997, [Reviewed] - Possible involvement of nitric oxide synthase in oxidative stress-induced endothelial cell injury
M Ishii; T Yamamoto; S Shimizu; A Sano; K Momose; Y Kuroiwa
PHARMACOLOGY & TOXICOLOGY, Apr. 1997, [Reviewed] - Mechanism of nitric oxide production induced by H2O2 in cultured endothelial cells
S Shimizu; M Ishii; T Yamamoto; K Momose
RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY, Mar. 1997, [Reviewed] - BRADYKININ INDUCES GENERATION OF REACTIVE OXYGEN SPECIES IN BOVINE AORTIC ENDOTHELIAL-CELLS
S SHIMIZU; M ISHII; T YAMAMOTO; T KAWANISHI; K MOMOSE; Y KUROIWA
RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY, Jun. 1994, [Reviewed]
MISC
- 学校薬剤師による喫煙防止教育での加熱式タバコの取り扱いに関する調査
Dec. 2022, [Reviewed]
Last - 加熱式タバコ使用者に対する禁煙支援についての薬局薬剤師の意識調査
Jul. 2022, [Reviewed]
Last, Corresponding - 頭痛予防薬の市販化に関する頭痛患者の意識調査
Jun. 2022, [Reviewed]
Lead, Corresponding - トリプタン製剤を使用している頭痛患者の予防薬の使用状況と新規予防薬への期待度調査
Apr. 2022, [Reviewed]
Lead, Corresponding - 鎮痛薬の使用状況からみた頭痛医療の課題
Feb. 2022, [Reviewed]
Lead, Corresponding - 頭痛予防薬のスイッチOTC化に関する薬局薬剤師の意識調査
Jan. 2022, [Reviewed]
Lead, Corresponding - Yahoo!知恵袋におけるロキソニンに関する疑問や不安の発言解析
Nov. 2021, [Reviewed]
Last, Corresponding - 薬局での加熱式タバコ使用者に対する禁煙支援の実態調査：横断研究
Aug. 2021, [Reviewed]
Last, Corresponding - Yahoo!知恵袋における加熱式タバコに関する質問の発言解析
Jul. 2021, [Reviewed]
Last, Corresponding - Yahoo!知恵袋における電子タバコ(ベイプ)に関する質問の発言解析
Apr. 2021, [Reviewed]
Last, Corresponding - ソーシャルメディアにおけるトリプタン製剤に関する疑問や不安の発言解析
Apr. 2020, [Reviewed]
Lead, Corresponding - 薬局での実務実習における禁煙支援の現状
Dec. 2019, [Reviewed]
Last - ソーシャルメディアにおける受動喫煙に関する質問の発言解析
2019, [Reviewed] - 改訂薬学教育モデル・コアカリキュラムにおける実務実習で関わるべき代表的な8疾患の実習実施状況調査
山本 仁美; 唐沢 浩二; 松林 智子; 熊木 良太; 柴田 佳太; 谷岡 利裕; 滝 伊織; 田島 正教; 北原 加奈之; 阿部 誠治; 石井 正和; 田中 佐知子; 佐々木 忠徳; 原 俊太郎; 向後 麻里; 加藤 裕久; 中村 明弘
日本薬学会年会要旨集, Mar. 2018
(公社)日本薬学会 - 非燃焼・加熱式タバコを販売している薬局の調査
2018, [Reviewed] - Tyrphostin AG化合物による活性酸素感受性Ca2+透過性チャネルTRPM2の活性化抑制
Mar. 2015 - MAOA,MTHFR,TNF‐βの多型性は片頭痛の病態に関与する独立した因子である
原一; 飯島昭二; 黒野裕子; 佐藤勝; 國本雅也; 高橋丈二; 今川篤子; 石井正和; 清水俊一; 坂入由貴; 長嶺歩; 内藤結花; 木内祐二; 宇佐美信乃
日本神経学会学術大会プログラム・抄録集, 2013 - トリプタンの効かない片頭痛患者を予測する因子の解析
原 一; 國本 雅也; 飯島 昭二; 黒野 裕子; 石井 正和; 清水 俊一; 木内 祐二; 高橋 丈二; 今川 篤子; 宇佐美 信乃
臨床神経学, Dec. 2012
(一社)日本神経学会 - 片頭痛患者における薬物乱用頭痛発症に関与する因子の検討
加藤 大貴; 石井 正和; 女屋 朋美; 笠井 英世; 清水 俊一; 木内 祐二; 河村 満
臨床神経学, Dec. 2011
(一社)日本神経学会 - 片頭痛患者における薬物乱用頭痛発症に関与する因子の検討
加藤 大貴; 石井 正和; 女屋 朋美; 笠井 英世; 清水 俊一; 木内 祐二; 河村 満
日本頭痛学会誌, Nov. 2011
(一社)日本頭痛学会 - 片頭痛スクリーナーによる女性片頭痛患者の解析
坂入由貴; 石井正和; 内藤結花; 今川篤子; 高橋丈二; 清水俊一; 増田豊; 原一; 宇佐美信乃; 木内祐二
日本薬学会年会要旨集, 05 Mar. 2011 - 片頭痛患者に対するトリプタン系薬物反応性の予測モデルの構築
坂入由貴; 石井正和; 内藤結花; 長嶺歩; 今川篤子; 高橋丈二; 清水俊一; 増田豊; 原一; 宇佐美信乃; 木内祐二
日本薬学会年会要旨集, 05 Mar. 2011 - 片頭痛患者における薬物乱用頭痛発症予測モデルの構築
女屋 朋美; 石井 正和; 加藤 大貴; 笠井 英世; 清水 俊一; 河村 満; 木内 祐二
日本薬学会年会要旨集, Mar. 2011
(公社)日本薬学会 - Treatment of non-responders and poor responders to triptan in patients with migraine
The Showa University journal of pharmaceutical sciences, 2011, [Reviewed] - The role of pharmacists in the medication of patients with headache: the need to support and guide self-medication and to provide medical cooperation
The Showa University journal of pharmaceutical sciences, 2011, [Reviewed] - トリプタン系薬物反応性の予測モデルの構築
坂入由貴; 石井正和; 内藤結花; 長嶺歩; 今川篤子; 高橋丈二; 清水俊一; 増田豊; 原一; 宇佐美信乃; 木内祐二
日本医療薬学会年会講演要旨集, 25 Oct. 2010 - トリプタン系薬物反応性の予測モデルの構築
坂入由貴; 石井正和; 内藤結花; 長嶺歩; 今川篤子; 高橋丈二; 清水俊一; 増田豊; 原一; 宇佐美信乃; 木内祐二
日本薬学会関東支部大会講演要旨集, 02 Oct. 2010 - 薬局・薬店での薬物乱用頭痛患者に対する薬剤師の役割~頭痛医療における薬局・薬店を含めた医療連携の必要性~
飯塚亮太; 石井正和; 内藤結花; 長嶺歩; 木内祐二
日本薬学会年会要旨集, 05 Mar. 2010 - 多変量解析及び共分散構造分析を用いた睡眠時ブラキシズム発症に関与するリスクファクターの解析
Mar. 2010 - 昭和大学における実務実習事前学習への取り組みとその評価~病棟実習~
中谷良人; 石井正和; 向後麻里; 栗原竜也; 神山紀子; 佐口健一; 小林靖奈; 山元俊憲; 加藤裕久
日本医療薬学会年会講演要旨集, 2010 - Scoring system for prediction of clinical response to triptans in migraine patients
Ayumu Nagamine; Masakazu Ishii; Yuika Naito; Atsuko Imagawa; Johji Takahashi; Hajime Hara; Shino Usami; Yuji Kiuchi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010 - Elucidating of migraine by the structural equation modeling approach
Ayumu Nagamine; Masakazu Ishii; Yuka Kimura; Yuika Naito; Yukiko Hosaka; Yuko Naito; Atsuko Imagawa; Johji Takahashi; Kenji Shida; Shunichi Shimizu; Yutaka Masuda; Hajime Hara; Shino Usami; Yuji Kiuchi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010 - Investigation of gene polymorphisms and personality traits in migraine by multivariate analysis
Ayumu Nagamine; Masakazu Ishii; Yuika Naito; Yukiko Hosaka; Yuko Naito; Hideto Oyamada; Atsuko Imagawa; Johji Takahashi; Kenji Shida; Shunichi Shimizu; Katsuji Oguchi; Yutaka Masuda; Hajime Hara; Shino Usami; Yuji Kiuchi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010 - Guidance by the school pharmacist for safe handling and storage of medicine
The Showa University journal of pharmaceutical sciences, 2010, [Reviewed] - 未破裂脳動脈溜には保存治療を選ぶべき
2010, [Reviewed] - 多変量解析と共分散構造分析の手法を用いた片頭痛の病態解明
長嶺歩; 石井正和; 内藤結花; 木村友香; 保坂悠紀子; 内藤祐子; 小山田英人; 今川篤子; 高橋丈二; 信太賢治; 清水俊一; 小口勝司; 増田豊; 原一; 宇佐美信乃; 木内祐二
日本薬学会関東支部大会講演要旨集, 03 Oct. 2009 - 薬物乱用頭痛患者に対する薬剤師の対応の現状と今後の課題~頭痛の地域連携クリニカルパス導入の必要性~
飯塚亮太; 石井正和; 内藤結花; 長嶺歩; 木内祐二
日本薬学会関東支部大会講演要旨集, 03 Oct. 2009 - 睡眠時ブラキシズム発症に関与する因子構造の解析 共分散構造分析を用いた因子モデル図の作成
Mar. 2009 - Inhibitory effect of lomerizine, an anti-migraine drug, on serotonin-induced vasoconstriction of rat basilar artery
Shunsuke Kobayashi; Masakazu Ishii; Shunichi Shimizu; Yuji Kiuchi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009 - Association between gene polymorphisms and clinical response to triptans in migraine
Yuika Naito; Masakazu Ishii; Atsuko Imagawa; Johji Takahashi; Hajime Hara; Shino Usami; Yuji Kiuchi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009 - Investigation of gene polymorphisms and personality traits in migraine by multivariate analysis
Yuika Naito; Masakazu Ishii; Yukiko Hosaka; Yuko Naito; Hideto Oyamada; Atsuko Imagawa; Johji Takahashi; Kenji Shida; Shunichi Shimizu; Katsuji Oguchi; Yutaka Masuda; Hajime Hara; Shino Usami; Yuji Kiuchi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009 - アナフィラキシーショック時の学校教職員によるアドレナリン注射 ～薬剤師が行うべき指導と今後の展望～
2009 - 薬学部6年制における救命救急医療教育の必要性 基準薬局薬剤師の意識調査
保坂 悠紀子; 石井 正和; 管野 恵; 清水 俊一; 木内 祐二
日本薬学会年会要旨集, Mar. 2008
(公社)日本薬学会 - 片頭痛予防薬である三環系抗うつ薬amitriptylineの作用機序解明
小池 慎太郎; 石井 正和; 森 泰生; 清水 俊一; 木内 祐二
日本薬学会年会要旨集, Mar. 2008
(公社)日本薬学会 - A pyrazole compound selectively inhibits receptor activated TRPC3 channel
Kenta Kato; Shigeki Kiyonaka; Motohiro Nishida; Masakazu Ishii; Emiko Mori; Takuro Numaga; Takashi Yoshida; Takafumi Miki; Tsutomu Kobayashi; Takashi Morii; Itaru Harnachi; Minoru Wakamori; Yasuo Mori
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008 - Analysis of gene polymorphisms and personality traits in migraine
Yukiko Hosaka; Yukiko Hosaka; Masakazu Ishii; Hideto Oyamada; Shunichi Shimizu; Katsuji Oguchi; Shino Usami; Yuji Kiuchi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008 - Inhibitory effect of lomerizine, a diphenylpiperazine Ca2+ channel blocker, on 5-HT-induced Ca2+ influx in vascular smooth muscle cells
Shintarou Koike; Masakazu Ishii; Shunichi Shimizu; Yasuo Mori; Yuji Kiuchi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008 - The effects of BH4 treatment in the development of the cardiac hypertrophy and fibrosis by chronic pressure overload in rats
Sumito Kumagai; Masaaki Ishibashi; Toshihitc Hiroi; Teruaki Wajima; Masakazu Ishii; Yuji Kiuchi; Shunichi Shimizu
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008 - Analysis of gene polymorphisms and personality traits in migraine
Yuika Naito; Masakazu Ishii; Yukiko Hosaka; Yuko Naito; Hideto Oyamada; Atsuko Imagawa; Johji Takahashi; Kenji Shida; Shunichi Shimizu; Katsuji Oguchi; Yutaka Masuda; Hajime Hara; Shino Usami; Yuji Kiuchi
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2008 - 喘息患者の末梢血単球における活性酸素感受性Ca2+透過性チャネルTRPM2の機能亢進
垣花 優子; 根来 孝治; 遠藤 寛之; 向後 麻里; 石井 正和; 森 泰生; 戸部 敞; 木内 祐二; 清水 俊一
日本薬学会年会要旨集, Mar. 2007
(公社)日本薬学会 - Serotonin transporter protein polymorphisms and personality traits in migraine
Yuko Naito; Masakazu Ishii; Hideto Oyamada; Shunichi Shimizu; Katsuji Oguchi; Shino Usami; Yuji Kiuchi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007 - Reduction of TRPC channel-mediated Ca2+influx by Ca2+channel blockers for migraine prevention
Akiko Nakamura; Masakazu Ishii; Shunichi Shimizu; Tamio Hagiwara; Akira Miyazaki; Yasuo Mori; Yuji Kiuchi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007 - Pharmacological characterization of Ca2+ response and cell death induced by hydrogen peroxide in rat beta-cell line RIN-51F
Masakazu Ishii; Masakazu Ishii; Shunichi Shimizu; Tamio Hagiwara; Akiko Nakamura; Miyazaki Akira; Yasuo Mori; Yuji Kiuchi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007 - Pharmacological characterization of Ca2+ response and cell death induced by hydrogen peroxide in rat beta-cell line RIN-5F
Masakazu Ishii; Masakazu Ishii; Shunichi Shimizu; Tamio Hagiwara; Akiko Nakamura; Miyazaki Akira; Yasuo Mori; Yuji Kiuchi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007 - Blockade of Ca2+ entry through TRPC channels by naphthalene derivatives
Shunichi Shimizu; Masakazu Ishii; Satoru Sugisawa; Kazuki Tomura; Tamio Hagiwara; Akira Miyazaki; Yasuo Mori; Yuji Kiuchi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007 - Role of BH4/NO synthase in the development of cardiac hypertrophy induced by pressure overload
Masaaki Ishibashi; Shunichi Shimizu; Teruaki Wajima; Masakazu Ishii; Yuji Kiuchi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007 - 学校でのエピネフリン自己注射製剤（エピペン）への対応の現状と今後の課題
Jan. 2007 - FOXP3遺伝子によるCa2+流入メカニズム制御に関する検討
Mar. 2006 - 活性酸素刺激によるBH4合成誘導におけるJak-STAT経路の関与
廣井 理人; 清水 俊一; 石井 正和; 萩原 民雄; 宮崎 章; 木内 祐二
日本薬学会年会要旨集, Mar. 2006
(公社)日本薬学会 - 血管内皮細胞におけるbFGF刺激によるErk経路を介したテトラヒドロビオプテリン合成誘導
佐々木 哲哉; 清水 俊一; 石井 正和; 萩原 民雄; 宮崎 章; 木内 祐二
日本薬学会年会要旨集, Mar. 2006
(公社)日本薬学会 - 酸化的ストレス感受性TRPM2チャネルの安定発現によるH2O2誘導性A172ヒトグリオブラストーマ細胞死の促進
小山 晃紀; 清水 俊一; 石井 正和; 萩原 民雄; 宮崎 章; 木内 祐二
日本薬学会年会要旨集, Mar. 2006
(公社)日本薬学会 - エピネフリン自己注射携帯簡易キット製剤(エピペン)の処方および調剤の現状と今後の課題
小林 真理子; 石井 正和; 木内 祐二
日本薬学会年会要旨集, Mar. 2006
(公社)日本薬学会 - 患者情報を用いた研究の現状把握と環境整備の必要性
宮原 綾子; 石井 正和; 向後 麻里; 木内 祐二
日本薬学会年会要旨集, Mar. 2006
(公社)日本薬学会 - インスリン分泌細胞における過酸化水素による細胞内カルシウム濃度上昇への電位依存性カルシウムチャネルとTRPM2チャネルの関与
石井 正和; 清水 俊一; 森 泰生; 木内 祐二
日本薬学会年会要旨集, Mar. 2006
(公社)日本薬学会 - 多変量解析を用いたうつ病の発症と薬物反応に関与する性格および遺伝的因子の抽出
奥 有紀子; 保坂 悠紀子; 石井 正和; 小山田 英人; 大坪 天平; 三村 將; 上島 国利; 小口 勝司; 木内 祐二
日本薬学会年会要旨集, Mar. 2006
(公社)日本薬学会 - Reduction of myocardial infarct size by tetrahydrobiopterin: Possible involvement of mitochondrial K-ATP channels activation through nitric oxide production
T Wajima; S Shimizu; M Ishii; Y Kiuchi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006 - Basic fibroblast growth factor induces tetrahydrobiopterin synthesis through stimulation of Erk pathway in vascular endothelial cells
T Sasaki; S Shimizu; M Ishii; T Hagiwara; A Miyazaki; Y Kiuchi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006 - Discovery of novel TRPC channel blockers
S Kiyonaka; M Nishida; K Kato; M Wakamori; E Mori; M Ishii; T Kobayashi; Y Mori
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006 - Physiological role and activation mechanism of the oxidative stress-susceptible TRPM2 Ca2+ channel in immunocytes
S Yamamoto; S Shimizu; M Ishii; Y Hara; T Hagiwara; T Negoro; M Nishida; T Tobe; Y Kiuchi; Y Mori
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006 - Facilitation of H2O2-induced A172 human glioblastoma cell death by stable expression of oxidative stress-sensitive TRPM2 channels
A Oyama; M Ishii; S Shimizu; Y Kiuchi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006 - 患者情報を用いた研究の現状把握と環境整備の必要性
2006, [Reviewed] - Physiological role and activation mechanism of the oxidative stress-susceptible TRPM2 Ca2+ channel in immunocytes
S Yamamoto; S Shimizu; M Ishii; T Hagiwara; Y Hara; T Negoro; M Nishida; T Tobe; Y Kiuchi; Y Mori
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2005 - アナフィラキシー患者をとりまく環境整備の必要性
2005 - 食物依存性運動誘発アナフィラキシー
2005 - エピネフリン自己注射キット製剤（エピペン）の適応拡大と薬剤師の関わり
2005 - 命を救うエピネフリン自己注射
2005 - 命を救うエピネフリン自己注射 ～臨床適応拡大と今後の課題～
2005 - 食物アレルギーにもエピネフリンを
2005 - U937におけるH2O2刺激によるTRPM2を介したCa2+流入のサイトカイン産生及びアポトーシス誘導に及ぼす影響
山本 伸一郎; 清水 俊一; 根来 孝治; 石井 正和; 原 雄二; 西田 基宏; 戸部 敞; 森 泰生; 木内 祐二
日本薬学会年会要旨集, Mar. 2004
(公社)日本薬学会 - インスリン分泌細胞における細胞内カルシウム濃度変化へのテトラヒドロビオプテリンの影響
渡部 達也; 石井 正和; 清水 俊一; 木内 祐二
日本薬理学雑誌, Jan. 2004
(公社)日本薬理学会 - Possible involvement of hydroxyl radical on the stimulation of tetrahydrobiopterin synthesis by H2O2 and peroxynitrite in vascular endothelial cells
S Shimizu; M Ishii; Y Miyasaka; Y Kiuchi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004 - Potent inhibition of B cell receptor signaling by a novel Ca2+ channel blocker
M Nishida; S Kiyonaka; T Mizumoto; T Numaga; E Mori; M Ishii; T Kobayashi; Y Mori
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004 - Possible involvement of hydroxyl radical in H2O2-induced calcium influx through TRPM2 channel
M Ishii; Y Hara; S Yamamoto; Y Mori; S Shimizu; Y Kiuchi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004 - Implication of Ca2+ entry through oxidative stress sensitive TRPM2 channel on IL-8 production by H2O2 in U937 cells
S Yamamoto; S Shimizu; T Negoro; M Ishii; Y Hara; M Nishida; T Tobe; Y Mori; Y Kiuchi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004 - Role of tetrahydrobiopterin on L-arginine-induced increase in cytosolic Ca2+ concentration in beta-cell
T Watabe; M Ishii; S Shimizu; Y Kiuchi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004 - 過酸化水素によるテトラヒドロビオプテリン合成機構の解明
石井 正和; 清水 俊一; 木内 祐二
日本薬学会年会要旨集, Mar. 2003
(公社)日本薬学会 - 血管内皮細胞におけるbFGFによるBH4合成の促進
宮坂 善之; 山本 伸一郎; 新本 里香; 石井 正和; 清水 俊一; 木内 祐二
日本薬学会年会要旨集, Mar. 2003
(公社)日本薬学会 - Effects of reactive oxygen species on tetrahydrobiopterin content in vascular endothelial cells.
Y Miyasaka; S Shimizu; R Shinmoto; M Ishii; Y Kiuchi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2003 - TRPチャネル 受容体活性化されるCa2+流入機構
2001, [Reviewed] - インスリンによるマウス血管内皮細胞でのテトラヒドロビオプテリン合成促進へのプロテインキナーゼCの関与
Aug. 2000 - 血管外膜は血管機能調節に関与する？
2000, [Reviewed]
Books and other publications
Research Themes
- 加熱式タバコによる生理痛の誘発・悪化の実態調査
Apr. 2023 - Mar. 2024 - 天候変化により発症する片頭痛に対する五苓散の短期使用効果および無反応例の解析
Grant-in-Aid for Scientific Research (C)
Teikyo Heisei University
Apr. 2021 - Mar. 2024 - 片頭痛の臭い過敏と加熱式タバコによる頭痛悪化との関係
Apr. 2022 - Mar. 2023 - 薬局での加熱式タバコの販売と薬剤師の加熱式タバコ使用者に対する禁煙支援の実態調査
Apr. 2018 - Mar. 2019 - 薬局薬剤師の受動喫煙対策に関する意識調査：薬局の敷地内全面禁煙化を阻む要因
Apr. 2017 - Mar. 2018 - より良い禁煙治療を患者に提供するための試み：治療反応性の予測と医療連携
Apr. 2016 - Mar. 2017 - TRPM2チャネル欠損マウスにおける固形癌の成長抑制とその機構
Apr. 2012 - Mar. 2016 - Apr. 2009 - Mar. 2012
- Aggravation mechanism of cardiac ischemia-reperfusion injury through oxidative stress-sensitive channel TRPM2
Grant-in-Aid for Scientific Research (C)
Showa University
2009 - 2011
Aims. Transient receptor potential melastatin 2(TRPM2) is a Ca^<2+-> permeable nonselective cation channel activated by oxidative stress, and is expressed in neutrophils and cardiomyocytes. This study examined whether TRPM2 contributes to myocardial ischemia-reperfusion(I/R) injury, in which acute inflammation with oxidative stress is closely involved. Methods and Results. Wild-type(Trpm2^<+/+>) and Trpm2 knockout(Trpm2^<-/->) mice were exposed to I/R by ligation of the left coronary artery. Myocardial infarction following I/R but not ischemia alone was reduced in Trpm2^<-/-> mice compared to Trpm2^<+/+> mice, and cardiac contractile function was also improved in Trpm2^<-/-> mice. Moreover, neutrophil accumulation in the reperfused area was lowered in Trpm2^<-/-> mice. When Trpm2^<+/+> or Trpm2^<-/-> polymorphonuclear leukocytes(PMNs) were administered to the Trpm2^<-/-> heart ex vivo through perfusate or in vivo by intravenous injection, Trpm2^<+/+> PMNs induced more severe cardiac injury following I/R compared with Trpm^<2-/-> PMNs. In Trpm2^<+/+> but not in Trpm2^<-/-> PMNs, the combination of H_2O_2 and leukotriene B_4(LTB_4) resulted in enhancement of the increase in intracellular Ca^<2+> and their adhesion to endothelial cells. Conclusions. These findings indicate that TRPM2 is implicated in the development of myocardial reperfusion injury. Accumulation of neutrophils in the heart triggered by activation of neutrophil TRPM2 by H_2O_2 and LTB_4 is likely to have a crucial role in myocardial I/R injury. - インスリン分泌細胞におけるTRPM2チャネル活性化機構の解明と創薬への応用
Apr. 2007 - Mar. 2009 - インスリン分泌細胞におけるTRPM2チャネルの生理的意義に関する基礎研究
Apr. 2003 - Mar. 2005
