Takashi Yoshida
| Faculty of Pharmaceutical Sciences,Department of Pharmaceutical Sciences | Associate Professor |
Last Updated :2025/06/19
■Researcher basic information
■Research activity information
Paper
- Dynamic remodeling of TRPC5 channel-caveolin-1-eNOS protein assembly potentiates the positive feedback interaction between Ca2+ and NO signals.
Reiko Sakaguchi; Nobuaki Takahashi; Takashi Yoshida; Nozomi Ogawa; Yoshifumi Ueda; Satoshi Hamano; Kaori Yamaguchi; Seishiro Sawamura; Shinichiro Yamamoto; Yuji Hara; Tomoya Kawamoto; Ryosuke Suzuki; Akito Nakao; Masayuki X Mori; Tetsushi Furukawa; Shunichi Shimizu; Ryuji Inoue; Yasuo Mori
The Journal of biological chemistry, 21 Aug. 2024 - Periodontal Ligaments Enhance Neurite Outgrowth in Trigeminal Ganglion Neurons through Wnt5a Production Induced by Mechanical Stimulation
Kaori Takahashi; Takashi Yoshida; Minoru Wakamori
American Journal of Physiology-Cell Physiology, 14 Nov. 2022, [Reviewed] - Identification of ultra-rare disruptive variants in voltage-gated calcium channel-encoding genes in Japanese samples of schizophrenia and autism spectrum disorder
Chenyao Wang; Shin-ichiro Horigane; Minoru Wakamori; Shuhei Ueda; Takeshi Kawabata; Hajime Fujii; Itaru Kushima; Hiroki Kimura; Kanako Ishizuka; Yukako Nakamura; Yoshimi Iwayama; Masashi Ikeda; Nakao Iwata; Takashi Okada; Branko Aleksic; Daisuke Mori; Takashi Yoshida; Haruhiko Bito; Takeo Yoshikawa; Sayaka Takemoto-Kimura; Norio Ozaki
Translational Psychiatry, 26 Feb. 2022, [Reviewed] - Mode-selective inhibitory effects of eugenol on the mouse TRPV1 channel
Kaori Takahashi; Takashi Yoshida; Minoru Wakamori
Biochemical and Biophysical Research Communications, Jun. 2021, [Reviewed]
Corresponding - Capsaicin and Proton Differently Modulate Activation Kinetics of Mouse Transient Receptor Potential Vanilloid-1 Channel Induced by Depolarization
Kaori Takahashi; Kentaro Araki; Hideo Miyamoto; Rikimaru Shirakawa; Takashi Yoshida; Minoru Wakamori
Frontiers in Pharmacology, 20 May 2021, [Reviewed] - Paeonol, an Ingredient of Kamishoyosan, Reduces Intracellular Lipid Accumulation by Inhibiting Glucocorticoid Receptor Activity in 3T3-L1 Cells.
Masayuki Izumi; Takashi Yoshida; Takashi Nakamura; And Minoru Wakamori
Nutrients, 24 Jan. 2020 - Synthesis of quinolyl-pyrrole derivatives as novel environment-sensitive fluorescent probes
Ryo Shinotsuka; Toru Oba; Takahiro Mitome; Takuto Masuya; Satoshi Ito; Yukie Murakami; Tomoko Kagenishi; Yutaka Kodama; Masaru Matsuda; Takashi Yoshida; Minoru Wakamori; Masamichi Ohkura; Junichi Nakai
Journal of Photochemistry and Photobiology A: Chemistry, Sep. 2019 - Pharmacological properties of SAK3, a novel T-type voltage-gated Ca2+ channel enhancer
Yasushi Yabuki; Kazuya Matsuo; Hisanao Izumi; Hidaka Haga; Takashi Yoshida; Minoru Wakamori; Akikazu Kakei; Kenji Sakimura; Takaichi Fukuda; Kohji Fukunaga
NEUROPHARMACOLOGY, May 2017, [Reviewed] - Inhibitory effects of AG490 on H2O2-induced TRPM2-mediated Ca2+ entry
Shunichi Shimizu; Ryo Yonezawa; Tamio Hagiwara; Takashi Yoshida; Nobuaki Takahashi; Satoshi Hamano; Takaharu Negoro; Takahiro Toda; Minoru Wakamori; Yasuo Mori; Masakazu Ishii
EUROPEAN JOURNAL OF PHARMACOLOGY, Nov. 2014, [Reviewed] - Development of Purkinje cell degeneration in a knockin mouse model reveals lysosomal involvement in the pathogenesis of SCA6.
Toshinori Unno; Minoru Wakamori; Masato Koike; Yasuo Uchiyama; Kinya Ishikawa; Hisahiko Kubota; Takashi Yoshida; Hiroko Sasakawa; Christoph Peters; Hidehiro Mizusawa; Kei Watase
Proceedings of the National Academy of Sciences of the United States of America, 23 Oct. 2012 - A Missense Mutation of the Gene Encoding Voltage-Dependent Sodium Channel (Na(v)1.1) Confers Susceptibility to Febrile Seizures in Rats
Tomoji Mashimo; Iori Ohmori; Mamoru Ouchida; Yukihiro Ohno; Toshiko Tsurumi; Takafumi Miki; Minoru Wakamori; Shizuka Ishihara; Takashi Yoshida; Akiko Takizawa; Megumi Kato; Masumi Hirabayashi; Masashi Sasa; Yasuo Mori; Tadao Serikawa
JOURNAL OF NEUROSCIENCE, Apr. 2010, [Reviewed] - Mechanosensitive TRP channels in osteoblasts
Takashi Yoshida; Yuki Miyajima; Minoru Wakamori
INTERFACE ORAL HEALTH SCIENCE 2009, 2010, [Reviewed] - Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound
Shigeki Kiyonaka; Kenta Kato; Motohiro Nishida; Kazuhiro Mio; Takuro Numaga; Yuichi Sawaguchi; Takashi Yoshida; Minoru Wakamori; Emiko Mori; Tomohiro Numata; Masakazu Ishii; Hiroki Takemoto; Akio Ojida; Kenta Watanabe; Aya Uemura; Hitoshi Kurose; Takashi Morii; Tsutomu Kobayashi; Yoji Sato; Chikara Sato; Itaru Hamachi; Yasuo Mori
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Mar. 2009, [Reviewed] - Potentiation of TRPC5 channel activity by Ca2+
Minoru Wakamori; Takashi Yoshida; Shinichiro Yamamoto; Yasuo Mori
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009, [Reviewed] - FACILITATION OF TRPC5 CHANNEL BY CALCIUM
Minoru Wakamori; Takashi Yoshida; Shinichiro Yamamoto; Yasuo Mori
JOURNAL OF PHYSIOLOGICAL SCIENCES, 2009 - Nitric oxide activates TRP channels by cysteine S-nitrosylation
Takashi Yoshida; Ryuji Inoue; Takashi Morii; Nobuaki Takahashi; Shinichiro Yamamoto; Yuji Hara; Makoto Tominaga; Shunichi Shimizu; Yoji Sato; Yasuo Mori
NATURE CHEMICAL BIOLOGY, Nov. 2006, [Reviewed] - Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells
S Shimizu; T Yoshida; M Wakamori; M Ishii; T Okada; M Takahashi; M Seto; K Sakurada; Y Kiuchi; Y Mori
JOURNAL OF PHYSIOLOGY-LONDON, Jan. 2006, [Reviewed] - Comprehensive analysis of the ascidian genome reveals novel insights into the molecular evolution of ion channel genes
Y Okamura; A Nishino; Y Murata; K Nakajo; H Iwasaki; Y Ohtsuka; M Tanaka-Kunishima; N Takahashi; Y Hara; T Yoshida; M Nishida; H Okado; H Watari; IA Meinertzhagen; N Satoh; K Takahashi; Y Satou; Y Okada; Y Mori
PHYSIOLOGICAL GENOMICS, Aug. 2005, [Reviewed] - A new high-throughput electrophysiology platform using voltage clamp noise analysis
M Taketani; T Yoshida; M Kojima; H Jiko; M Nakatani; N Katayama; Y Mori
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2005 - Photochemistry of benzophenone immobilized in a major groove of DNA: Formation of thermally reversible interstrand cross-link
K Nakatani; T Yoshida; Saito, I
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2002, [Reviewed] - LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death
Y Hara; M Wakamori; M Ishii; E Maeno; M Nishida; T Yoshida; H Yamada; S Shimizu; E Mori; J Kudoh; N Shimizu; H Kurose; Y Okada; K Imoto; Y Mori
MOLECULAR CELL, Jan. 2002, [Reviewed]
MISC
- 三叉神経中脳路核における機械刺激負荷歯根膜細胞由来Wnt5aの役割
高橋 かおり; 吉田 卓史; 中村 卓史; 若森 実
Journal of Oral Biosciences Supplement, Sep. 2023 - 亜鉛によるMC3T3-E1細胞分化亢進作用におけるカルシウム依存性カリウムチャネルの役割
吉田 卓史; 高橋 かおり; 中村 卓史; 若森 実
Journal of Oral Biosciences Supplement, Sep. 2018 - 骨芽細胞様細胞MC3T3-E1細胞に於ける亜鉛イオンによる過分極応答
光 夢凱; 吉田 卓史; 中村 卓史; 若森 実
Journal of Oral Biosciences Supplement, Sep. 2016 - The inhibitory mechanism of eugenol on TRPV1 channel
Takashi Yoshida; Kaori Takahashi; Minoru Wakamori
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014 - The inhibitory mechanism of eugenol on TRPV1 channel
Takashi Yoshida; Kaori Takahashi; Takashi Kikuchi; Minoru Wakamori
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013 - Spatio-temporal regulation of intracellular Ca2+ and NO signaling by the TRPC5 channel complex
Nobuaki Takahashi; Takashi Yoshida; Shinichiro Yamamoto; Yoshifumi Ueda; Yasuo Mori
JOURNAL OF PHYSIOLOGICAL SCIENCES, 2013 - The conflicting effects of eugenol on TRPV1 channel
Takashi Yoshida; Takashi Kikuchi; Kaori Takahashi; Minoru Wakamori
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012 - TRP channels play a role in the mouse osteoblast cell line MC3T3-E1 under shear stress
Takashi Yoshida; Minoru Wakamori
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011 - Modulation of TRPM5 channel activities by fatty acids
Minoru Wakamori; Takashi Yoshida; Takashi Kikuchi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010 - ナトリウムチャネル遺伝子Scn1a変異ラットの開発解析研究
芹川忠夫; 大守伊織; 大内田守; 大野行弘; 鶴見東志子; 三木崇史; 若森実; 石原靜; 吉田卓史; 滝沢明子; 加藤めぐみ; 平林真澄; 笹征史; 森泰生; 真下知士
てんかん治療研究振興財団研究年報, 2010 - Expression patterns of mechanosensitive TRP genes in MC3T3-E1 cells
Takashi Yoshida; Yuki Miyajima; Minoru Wakamori
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009 - TRP CHANNELS PLAY A ROLE IN MECHANICAL RESPONSES IN STRETCHED OSTEOBLASTS
Takashi Yoshida; Yuki Miyajima; Minoru Wakamori
JOURNAL OF PHYSIOLOGICAL SCIENCES, 2009 - A pyrazole compound selectively inhibits receptor activated TRPC3 channel
Kenta Kato; Shigeki Kiyonaka; Motohiro Nishida; Masakazu Ishii; Emiko Mori; Takuro Numaga; Takashi Yoshida; Takafumi Miki; Tsutomu Kobayashi; Takashi Morii; Itaru Harnachi; Minoru Wakamori; Yasuo Mori
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008 - A novel pyrazole derivative selectively inhibits TRPC3 channel.
Kenta Kato; Shigeki Kiyonaka; Motohiro Nishida; Masakazu Ishi; Emiko Mori; Takuro Numaga; Takashi Yoshida; Takafumi Miki; Tsutomu Kobayashi; Takashi Morii; Itaru Hamachi; Minoru Wakamori; Yasuo Mori
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007 - TRP channels: Molecular diversity and physiological function
Motohiro Nishida; Yuji Hara; Takashi Yoshida; Ryuji Inoue; Yasuo Mori
MICROCIRCULATION, Oct. 2006 - 【イオンチャネル創薬】 着眼点と新技術 ノイズ解析を用いた新しいハイスループット電気生理測定法 (日本薬理学雑誌)
吉田卓史; 片山統裕; 中谷将也; 小島正敏; 慈幸秀保; 森泰生; 竹谷誠
日本薬理学雑誌, Nov. 2005 - Ca透過チャネル研究の新展開 神経・筋の興奮から細胞増殖・細胞死に至るまで レドックスセンサーTRPチャネルの活性化機構とその薬理学・生理学的意義 (日本薬学会124年会講演要旨集)
森泰生; 原雄二; 吉田卓史
日本薬学会124年会講演要旨集, Mar. 2004 - Cystine oxidation activates Ca2+-permeable cation channel TRPC5
T Yoshida; M Nishida; Y Hara; Y Mori
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004 - 酸化ストレスに対する生体応答・抗酸化剤防御 カルシウムチャネル活性化のレドックス制御 (生化学)
森泰生; 原雄二; 吉田卓史; 西田基宏
生化学, Aug. 2002
Lectures, oral presentations, etc.
- 一酸化窒素のシステイン残基直接酸化修飾によるTRPチャネル活性化機構
吉田卓史; 若森実
第49回歯科基礎医学会学術大会, 30 Aug. 2007 - 一酸化窒素によるニトロシル化を介したTRP チャンネル活性化
高橋重成; 吉田卓史; 山本伸一郎; 森泰生
第84回日本生理学会大会, 20 Mar. 2007 - NOによるニトロシル化を介したTRPチャネル活性化とそのシグナル統合における意義
森泰生; 高橋重成; 山本紳一郎; 吉田卓史
細胞シグナリングの時空間統御機構解明への方略探索, 05 Oct. 2006 - Nitric-oxide directly activates TRP channels via oxidative cysteine modification
Takashi Yoshida; Yuji Hara; Nobuaki Takahashi; Shinichiro Yamamoto; Yasuo Mori
20th IUBMB International Congress of Biochemistry and Molecular biology, 18 Jun. 2006 - TRPチャネル拮抗剤による新規修飾方法の開発
加藤賢太; 清中茂樹; 西田基宏; 石井正和; 森恵美子; 沼賀拓郎; 吉田卓史; 三木崇史; 小林力; 森井孝; 浜地格; 若森実; 森泰生
第2回TRPチャネル研究会, 12 Jun. 2006 - Nitric-oxide-induced activation of TRPC5 Ca2+channel mediates a positive feedback loop in receptor-induced eNOS signaling
Yasuo Mori; Takashi Yoshida; Yuji Hara; Shinichiro Yamamoto
第27回生体膜と薬物の相互作用シンポジウム, 28 Nov. 2005 - シグナルソームにおけるNO産生によるTRPC5チャネルの活性化
吉田卓史; 原雄二; 飯沼ゆり子; 山本伸一郎; 西田基宏; 森泰生
第78回日本生化学会, 19 Oct. 2005 - システイン直接活性化を介したNOによるTRPC5活性化機構
吉田卓史; 飯沼ゆり子; 原雄二; 西田基宏; 森泰生
第78回日本薬理学会年会, 22 Mar. 2005 - 一酸化窒素とTRPC5カルシウムチャネルとのカップリング機構とその生理的意義
吉田卓史; 飯沼ゆり子; 西田基宏; 原雄二; 森泰生
The Second Symposium of Fukui Institute for Fundamental Chemistry, 06 Dec. 2004 - 内因性NOの直接酸化によるカルシウムチャネルTRPC5の活性化
吉田卓史; 西田基宏; 原雄二; 森泰生
第77回日本生化学会, 13 Oct. 2004 - 内因性一酸化窒素の直接酸化によるカルシウムチャネル TRPC5 の活性化
吉田卓史; 森泰生
バイオ分子センサー研究会, 08 Sep. 2004 - 細胞の運命を決定するイオンチャネル
森泰生; 吉田卓史; 原雄二
第81回日本生理学会大会, 02 Jun. 2004 - カルシウムチャネルTRPC5のシステイン酸化による活性化機構
吉田卓史; 西田基宏; 原雄二; 森泰生
第77回日本薬理学会年会, 08 Mar. 2004 - カルシウムチャネルTRPC5のシステイン酸化を介した活性化機構
吉田卓史; 西田基宏; 原雄二; 森泰生
第3回日本蛋白質科学界年会, 23 Jun. 2003 - カルシウムチャネル活性化のレドックス制御
森泰生; 原雄二; 吉田卓史; 西田基宏
第75回日本生化学会, 14 Oct. 2002
Research Themes
- The development of regulatory methods for osteocyte function using optogenetics
Grant-in-Aid for Challenging Research (Exploratory)
29 Jun. 2018 - 31 Mar. 2023 - The development of light-activatable proteins for inducing mechanical stimulation in the cells
Grant-in-Aid for Challenging Exploratory Research
Tohoku University
01 Apr. 2015 - 31 Mar. 2018 - Pathophysiological analysis of oral diseases caused by dysregulation of cation channels
Grant-in-Aid for Scientific Research (C)
Tohoku University
01 Apr. 2015 - 31 Mar. 2018 - Drug-delivery-system through ion channels
Grant-in-Aid for Challenging Exploratory Research
Tohoku University
01 Apr. 2013 - 31 Mar. 2015 - Identification of mechanosensitive channels responded to hypo-osmotic stress in the osteoblast
Grant-in-Aid for Young Scientists (B)
Tohoku University
2010 - 2011 - Functional analysis of oral sensation on the basis of signalplexes
Grant-in-Aid for Scientific Research (B)
Tohoku University
2009 - 2011 - The activation mechanisms of mechanosensitive cation channels in boneremodeling.
Grant-in-Aid for Young Scientists (B)
Tohoku University
2008 - 2009
