Ikumi Ito
| Faculty of Pharmaceutical Sciences,Department of Pharmaceutical Sciences | Lecturer |
Last Updated :2026/02/06
■Researcher basic information
■Research activity information
Paper
- Preparation and evaluation of water-absorbing swollen mini-tablet aimed at improving ingestion
Ikumi Ito; Akihiko Ito; Sakae Unezaki
Journal of Drug Delivery Science and Technology, 01 Apr. 2019 - Preparation of an oral acetaminophen film that is expected to improve medication administration: Effect of polyvinylpyrrolidone on physical properties of the film.
Ikumi Ito; Akihiko Ito; Sakae Unezaki
Drug discoveries & therapeutics, 2016
This study investigated the effect of polyvinylpyrrolidone (PVP) on a film containing carboxymethyl cellulose sodium (CMC) as a matrix to improve surface roughness caused by drug recrystallization. Acetaminophen (AA) was used as the model drug. Recrystallization is a problem encountered during the preparation of films that contain high drug doses, making them difficult to take. A film that does not disintegrate for clinical applications requires a smooth surface, moderate strength and elasticity, and a low level of adhesiveness to facilitate taking of the medication. Addition of PVP to the film formulation made the surface significantly smoother, and it was independent of the compounding method. Smooth films were obtained when the CMC concentration was kept constant and the amount of PVP was increased, but it also increased the adhesiveness and strength, and decreased the elasticity of the films. When high polymer concentration was kept constant and the ratio of CMC and PVP was varied, the films with smaller amounts of PVP tended to have a smoother surface and less adhesiveness. However, when the amount of PVP was reduced, the film strength increased and elasticity decreased. The amount of PVP had a negligible effect on drug dissolution behavior, making it useful for preparation of the AA film. However, it is necessary to determine the compounding method and the PVP load considering the adhesiveness, strength, and elasticity of the films. - Preparation and evaluation of gelling granules to improve oral administration.
Ikumi Ito; Akihiko Ito; Sakae Unezaki
Drug discoveries & therapeutics, Jun. 2015
We investigated the preparation of oral granules that are solid when stored and that will swell and gel via water absorption, to address problems experienced by patients when taking medication. Important physical properties of gelling granules include elasticity that is normally smooth, quick water absorption and swelling properties that allow easy swallowing. We selected gelatin (GEL), succinylated gelatin (SUC-GEL) and ι-carrageenan (CAR) as matrix polymers that can undergo gelation at room temperature or at cold temperatures. Saccharide and polyethylene glycol (PEG) were added to prepare the experimental granules. The best matrix gelling granule was SUC-GEL. When xylitol (XYL), sorbitol (SOR) and maltitol (MAL) were added, elasticity was improved, and PEG improved the granule's water absorption behavior, which is an important element involved in gelation. The best granules were prepared by selecting SUC-GEL as the matrix and adding a small amount of PEG and XYL in amounts equal to that of SUC-GEL.
MISC
- Factors Influencing Medical Consultation in People with Chronic Headaches and the Role of Pharmacists
Ikumi Ito; Hirotaka Katoh; Masakazu Ishii
BPB Reports, 2025
Pharmaceutical Society of Japan - Identifying Factors Influencing the Interictal Burden of Migraine in Women
Masakazu Ishii; Ikumi Ito; Hirotaka Katoh
BPB Reports, 2025
Pharmaceutical Society of Japan - Effects of Heated tobacco on Menstrual Pain and Headache and Awareness of Health Hazards of Smoking
Ito Ikumi; Ishii Masakazu
Japanese Journal of Tobacco Control, 20 Aug. 2024, [Reviewed]
Objective: To determine the effects of heated tobacco smoke and odor on menstrual pain and headache and awareness of the health hazards of smoking.
Methods: An Internet-based survey was conducted involving 600 women in their 20s to 40s who had menstrual pain.
Results: A total of 149 respondents complained of menstrual pain only, and 451 complained of both menstrual pain and headache. Of the respondents who complained of both menstrual pain and headache, 170 had migraine headaches, especially menstrually related migraine, and their physical condition was affected by the smoke and odor of heated tobacco, which worsened menstrual pain, headache, cough, phlegm and digestive symptoms such as nausea. On the other hand, most of the respondents did not understand that smoking causes dysmenorrhea, irregular menstruation, etc.
Conclusion: It was possible to clarify that the smoke and odor of heated tobacco adversely affect menstrual pain and headache. On the other hand, awareness of the health hazards of smoking is poor, and awareness of the relationship between smoking and women’s health problems such as menstrual pain and headaches needs to be increased through education and awareness activities., Japan Society for Tobacco Control - Relationship Between Smartphone Addiction and Headaches in People with Chronic Headache
Masakazu Ishii; Chiaki Manabe; Ikumi Ito; Hirotaka Katoh
BPB Reports, 2024
Pharmaceutical Society of Japan - Health risks of heated cigarettes and support for smoking cessation required from pharmacists
伊東育己; 石井正和
日本地域薬局薬学会誌, 2024 - Suitability of lighting environments of medical facilities for people with headaches
石井正和; 伊東育己; 森田朱乃; 加藤大貴
日本地域薬局薬学会誌, 2024 - Investigation of oral preparation that is expected to improve medication administration: Preparation and evaluation of tablet using ι-Carrageenan
青木真愛; 蛭田りな; 伊東育己
日本薬学会年会要旨集(Web), 2024 - Requirements of Pharmacists in Dealing with Headache Patients
Ito Ikumi; Ishii Masakazu
The Journal of Community Pharmacy and Pharmaceutical Sciences, 2024
Migraine is accompanied by severe pain, photophobia, nausea, and vomiting, placing a heavy burden on daily life. However, many patients and consumers with migraine have do not seek medical attention and use over-the-counter drugs at their own discretion. Easy, repeated use of antipyretic analgesics can lead to headaches due to overuse. In recent years, new acute care has been adopted and prophylactic drugs have been administered as prescription drugs. The prophylactic drug dimetotiazine has also been proposed as an over-the-counter drug. As the number of headache treatment options is increasing, the follow-up of patients, including the interictal period, is important. However, there are few cases where pharmacists are consulted. This paper outlines the roles required of pharmacists in the treatment of headaches, such as support for self-medication and self-care, and medical cooperation., Pharmacy Society of Japan - Current status of headache treatment follow-up using tracing reports by pharmacy pharmacists
Ito Ikumi; Ishii Masakazu; Kijima Tamotsu
Japanese Journal of Community Pharmacy, 30 Dec. 2023
To clarify the current status regarding information-gathering from headache patients, the use of tracing reports in daily operations, and consultation recommendations for headache patients, we conducted a questionnaire survey involving the nearest 400 pharmacies (400 pharmacists) from 400 medical institutions where headache specialists certified by the Japanese Headache Society work. The study was conducted by dividing the patients into two groups: “active group” (tracing reports are used or sometimes used) and “passive group” (tracing reports are used infrequently or not used). The results showed that the “active group” included only 60% of all respondents (63/105), but the implementation rate for headache patients was even lower (7/63), indicating that headache was not recognized as a disease necessitating the use of tracing reports. The “active group” was also more active in recommending medical examinations, but only verbally and not in writing. The rate of interviews with headache patients about the appropriate use of OTC drugs, acute care drugs, and side effects of triptans was low, suggesting that the patients' problems may have been overlooked. These may provide clues to promote medical cooperation., The Japanease Society of Cmmunity Pharmacy - 頭痛患者に対する健康サポート薬局の薬剤師による生活指導の実態調査
Oct. 2023 - The actual condition of headache caused by heated tobacco products in women
山本風夏; 加藤大貴; 伊東育己; 石井正和
健康開発, Sep. 2023 - Investigation on Headache Caused by Weather and Atmospheric Pressure Changes and Use of Goreisan
石井正和; 伊東育己; 加藤大貴
社会薬学, Jun. 2023 - Effects of Exercise Habits on Headaches
Ishii Masakazu; Ito Ikumi; Ikeda Marin; Katoh Hirotaka
Japanese Journal of Community Pharmacy, Jun. 2023, [Reviewed]
An Internet survey was conducted to clarify the state of exercise habits of headache patients and the effects of exercise habits on headaches. The subjects were men and women in their 20s to 40s who had headaches. Of the 650 headache sufferers, patients were divided into a migraine group (n = 248) and an other headaches group (n = 402). The impact of headaches on daily life was greater and the percentage of people with allodynia was higher in the migraine group. There was no difference in exercise habits between the two groups, and about 60% had no exercise habits. Walking was the most common form of exercise currently practiced by the patients with exercise habits, and about 45% felt that exercising when they did not have a headache prevented headaches. We further analyzed exercise habits by dividing the patients into an improvement group (performed exercise and did not get headaches) and a non-improvement group (exercise was not effective in preventing headaches). In the improvement group, many people thought that not only exercise but also light exercise, such as stretching, could prevent headaches. In addition, exercise prevented not only headache but also allodynia among allodynia patients in the improvement group. In this study, it was found that some people can prevent headaches by exercising, but many of those with headaches do not have exercise habits., The Japanease Society of Cmmunity Pharmacy - A survey on the lighting environment in the waiting room of a health support pharmacy : Patients with headache and lighting environment
Ishii Masakazu; Ito Ikumi; Katoh Hirotaka
Japanese Journal of Community Pharmacy, Jun. 2023, [Reviewed]
We investigated the lighting environment in the waiting room of a health support pharmacy. We sent a survey to pharmacists and examined whether the lighting environment was appropriate for headache patients. The recovery rate was 42.5% (170/400). In response to the question, “Do you think the environment for treating patients is a light environment friendly to headache patients?”, responses were divided into two groups: an appropriate group (n = 84) that answered “suitable” or “somewhat suitable”, and an inappropriate group (n = 83) that answered “not very suitable” or “not suitable”. Regarding the type of lighting, in the appropriate group the most common answer was LED; on the other hand, in the inappropriate group the most common answer was fluorescent. As for the color of the lighting, neutral white was the most common in both groups; however, the responses that answered incandescent color was higher in the appropriate group. As for the lighting method, there were few responses that answered indirect lighting in both groups; however, the ratio of responses for indirect lighting was higher in the appropriate group. There was no difference in the presence or absence of headache in the pharmacists between the two groups; however, in the inappropriate group, there were many pharmacists with migraine with photophobia. It is known that incandescent color and indirect lighting are the preferred lighting environment for migraine patients. Our findings suggest that pharmacists who themselves suffer from migraine have an understanding of the lighting environment suitable for headache patients., The Japanease Society of Cmmunity Pharmacy - The Current State of Headache Treatment and the Involvement of Pharmacists in Treatment of People with Chronic Headache
Masakazu Ishii; Hirotaka Katoh; Tamotsu Kijima; Ikumi Ito
BPB Reports, 2023
Pharmaceutical Society of Japan - Survey on Headache During COVID-19 Infection in People with Chronic Headache
Masakazu Ishii; Ikumi Ito; Hirotaka Katoh
BPB Reports, 2023
Pharmaceutical Society of Japan - Issues of counseling sales by pharmacists in the OTC conversion of dimethothiazine, a prophylactic drug for headache
伊東育己; 石井正和
日本薬学会年会要旨集(Web), 2023 - Issues in Counseling Sales by Pharmacists in the OTC Conversion of Dimetotiazine, a Prophylactic Drug for Headache
伊東育巳; 石井正和
Progress in Medicine, 2023 - Heated tobacco products-induced headache in people with migraine with osmophobia: Internet questionnaire survey
Ishii Masakazu; Katoh Hirotaka; Ito Ikumi
Japanese Journal of Tobacco Control, 28 Dec. 2022
Objective: We conducted a questionnaire survey to clarify the relationship between osmophobia in people with migraine and headache caused by the smoke and odor of heated tobacco products.
Methods: A questionnaire survey was conducted on the internet. The subjects were people with headache aged from 20s to 40s, and they were not limited to heated tobacco users.
Results: The number of valid responses was 627, which included 163 with migraine. In the migraine group, 77 had concomitant osmophobia and 86 did not. More migraine people with osmophobia had photophobia, phonophobia, and allodynia compared to patients with migraine without osmophobia. People with osmophobia had more discomfort, cough, sputum, nausea, odor sensitivities and headache than those without it by exposure to odor or smoke of heated tobacco products.
Conclusions: It has been found that migraine people with osmophobia are more likely to have headaches due to the smoke and odor of heated tobacco products. It is considered necessary to improve the quality of life of headache people by improving the smoking cessation environment., Japan Society for Tobacco Control - Survey of headaches caused by heated tobacco products in patients with headache
Ishii Masakazu; Katoh Hirotaka; Ito Ikumi
Japanese Journal of Tobacco Control, 07 Nov. 2022
Objective: We conducted a questionnaire survey to clarify headaches caused by the smoke and odor of heated tobacco products.
Methods: A questionnaire survey was conducted on the internet. The subjects were patients with headache aged from 20s to 40s, they were not limited to heated tobacco users.
Results: The number of valid responses was 627, which included 163 with migraine and 464 with other headaches. Migraine had a greater influence on daily life than other headaches, and the migraine group was significantly more likely to have headaches caused by the smoke and odor of cigarettes and heated tobacco products than the other headache group. In the migraine group, more non-smokers (n = 117) had headaches caused by the smoke and odor of heated tobacco as well as cigarettes than smokers (n = 46).
Conclusions: Among headache patients, it was clarified that migraine patients are more likely to have headache induced by the smoke and odor of cigarettes and heated tobacco products both by smoking and secondhand smoke. It is necessary to create a non-smoking environment without distinguishing between cigarettes and heated tobacco., Japan Society for Tobacco Control - Investigation of Oral Preparation That Is Expected to Improve Medication Administration: Preparation and Evaluation of Oral Gelling Tablet Using Sodium Alginate
Ito Ikumi; Ito Akihiko; Unezaki Sakae
YAKUGAKU ZASSHI, 2017
We investigated the preparation of a gelling tablet that swells and forms a gel upon absorbing water, and hence would be easy for patients to swallow. We prepared naked tablets and compressed coated tablets by the direct tableting or wet granule-compression methods, using the commonly prescribed drug acetaminophen (AA) and sodium alginate (AG) as a thickening agent. The tablets quickly absorbed water, had favorable gelling properties, low adhesiveness, appropriate drug dissolution profile, and at the same time, were easy to swallow. In the case of naked tablets, water absorption increased upon granulation, but gelling of AG interfere when AA and AG were present together. There was no change in the adhesiveness, and more than 30 min were required to achieve a 25% dissolution ratio. Compressed coated tablets that were made with AA in the inner layer and granulated AG in the outer layer showed improved dissolution behavior, it was about 90% dissolution ratio in 30 min, owing to the water absorption property of AG, and decreased adhesiveness. In this case, there was a difference in the outer layer thickness. As the outer layer amount increased, dissolution slowed, but it did not depend on the compression pressure. Our gelling tablet can be prepared by using AA (main drug) in the inner layer and an appropriate thickness of granulated AG in the outer layer of compressed coated tablets.
, The Pharmaceutical Society of Japan - Fundamental Discussion on Preparation of an Oral Acetaminophen Film that is Expected to Improve Medication Administration:: Effects of Plasticizer and Polymer on an Oral Film
Ito Ikumi; Ito Akihiko; Unezaki Sakae
Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences), 2016
We investigated the effects of plasticizers and polymers on the physical properties and drug dissolution capabilities of films containing a high drug dosage of in order to find formulations that would be easy for patients to swallow. In this study, acetaminophen (AA) was used as the model drug, and glycerin (GL) and polyethylene glycol 400 (PEG) were used as plasticizers. Carboxy methylcellulose sodium (CMC) and hydroxypropyl methylcellulose (HPMC) were used as polymers. Adding GL decreased the strength and tended to increase the elasticity of films made with either polymer. Adding PEG changed the characteristics of each polymer film differently. For CMC films, strength increased and elasticity did not change. In HPMC films, strength did not change, and elasticity increased. The level of adhesiveness can effect proper swallowing. Adding GL increased adhesiveness for CMC film only, while adding PEG increased adhesiveness in both polymers. In GL containing films, a relationship was observed between adhesiveness and elasticity, as elasticity seems to be a good indicator of adhesiveness. However, in films containing PEG, there was no consistent relationship, therefore both characteristics may require separate evaluation. Drug dissolution from all films was almost 100% after 30 minutes, and was not influenced by the plasticizers. For preparing AA films for drug administration purposes, we suggest that GL is suitable for CMC and PEG is suitable for HPMC. GL seems to be useful as a plasticizer because it has a moderate effect on both polymer matrices., Japanese Society of Pharmaceutical Health Care and Sciences
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