Ikumi Ito

Faculty of Pharmaceutical Sciences,Department of Pharmaceutical SciencesLecturer
Last Updated :2025/10/23

■Researcher basic information

Degree

  • Ph.D, Tokyo University of Pharmacy and Life Sciences, Mar. 2020

■Research activity information

Paper

  • Preparation and evaluation of water-absorbing swollen mini-tablet aimed at improving ingestion
    Ikumi Ito; Akihiko Ito; Sakae Unezaki
    Journal of Drug Delivery Science and Technology, 01 Apr. 2019
    DOI URL
  • Preparation of an oral acetaminophen film that is expected to improve medication administration: Effect of polyvinylpyrrolidone on physical properties of the film.
    Ikumi Ito; Akihiko Ito; Sakae Unezaki
    Drug discoveries & therapeutics, 2016
    This study investigated the effect of polyvinylpyrrolidone (PVP) on a film containing carboxymethyl cellulose sodium (CMC) as a matrix to improve surface roughness caused by drug recrystallization. Acetaminophen (AA) was used as the model drug. Recrystallization is a problem encountered during the preparation of films that contain high drug doses, making them difficult to take. A film that does not disintegrate for clinical applications requires a smooth surface, moderate strength and elasticity, and a low level of adhesiveness to facilitate taking of the medication. Addition of PVP to the film formulation made the surface significantly smoother, and it was independent of the compounding method. Smooth films were obtained when the CMC concentration was kept constant and the amount of PVP was increased, but it also increased the adhesiveness and strength, and decreased the elasticity of the films. When high polymer concentration was kept constant and the ratio of CMC and PVP was varied, the films with smaller amounts of PVP tended to have a smoother surface and less adhesiveness. However, when the amount of PVP was reduced, the film strength increased and elasticity decreased. The amount of PVP had a negligible effect on drug dissolution behavior, making it useful for preparation of the AA film. However, it is necessary to determine the compounding method and the PVP load considering the adhesiveness, strength, and elasticity of the films.
    DOI URL
  • Preparation and evaluation of gelling granules to improve oral administration.
    Ikumi Ito; Akihiko Ito; Sakae Unezaki
    Drug discoveries & therapeutics, Jun. 2015
    We investigated the preparation of oral granules that are solid when stored and that will swell and gel via water absorption, to address problems experienced by patients when taking medication. Important physical properties of gelling granules include elasticity that is normally smooth, quick water absorption and swelling properties that allow easy swallowing. We selected gelatin (GEL), succinylated gelatin (SUC-GEL) and ι-carrageenan (CAR) as matrix polymers that can undergo gelation at room temperature or at cold temperatures. Saccharide and polyethylene glycol (PEG) were added to prepare the experimental granules. The best matrix gelling granule was SUC-GEL. When xylitol (XYL), sorbitol (SOR) and maltitol (MAL) were added, elasticity was improved, and PEG improved the granule's water absorption behavior, which is an important element involved in gelation. The best granules were prepared by selecting SUC-GEL as the matrix and adding a small amount of PEG and XYL in amounts equal to that of SUC-GEL.
    DOI URL

MISC

■University education and qualification information

Qualifications, licenses

  • 01 May 2003
  • 01 Apr. 2016