Preparation and evaluation of water-absorbing swollen mini-tablet aimed at improving ingestion
Ikumi Ito; Akihiko Ito; Sakae Unezaki
Journal of Drug Delivery Science and Technology, 01 Apr. 2019

Preparation of an oral acetaminophen film that is expected to improve medication administration: Effect of polyvinylpyrrolidone on physical properties of the film.
Ikumi Ito; Akihiko Ito; Sakae Unezaki
Drug discoveries & therapeutics, 2016
This study investigated the effect of polyvinylpyrrolidone (PVP) on a film containing carboxymethyl cellulose sodium (CMC) as a matrix to improve surface roughness caused by drug recrystallization. Acetaminophen (AA) was used as the model drug. Recrystallization is a problem encountered during the preparation of films that contain high drug doses, making them difficult to take. A film that does not disintegrate for clinical applications requires a smooth surface, moderate strength and elasticity, and a low level of adhesiveness to facilitate taking of the medication. Addition of PVP to the film formulation made the surface significantly smoother, and it was independent of the compounding method. Smooth films were obtained when the CMC concentration was kept constant and the amount of PVP was increased, but it also increased the adhesiveness and strength, and decreased the elasticity of the films. When high polymer concentration was kept constant and the ratio of CMC and PVP was varied, the films with smaller amounts of PVP tended to have a smoother surface and less adhesiveness. However, when the amount of PVP was reduced, the film strength increased and elasticity decreased. The amount of PVP had a negligible effect on drug dissolution behavior, making it useful for preparation of the AA film. However, it is necessary to determine the compounding method and the PVP load considering the adhesiveness, strength, and elasticity of the films.

Preparation and evaluation of gelling granules to improve oral administration.
Ikumi Ito; Akihiko Ito; Sakae Unezaki
Drug discoveries & therapeutics, Jun. 2015
We investigated the preparation of oral granules that are solid when stored and that will swell and gel via water absorption, to address problems experienced by patients when taking medication. Important physical properties of gelling granules include elasticity that is normally smooth, quick water absorption and swelling properties that allow easy swallowing. We selected gelatin (GEL), succinylated gelatin (SUC-GEL) and ι-carrageenan (CAR) as matrix polymers that can undergo gelation at room temperature or at cold temperatures. Saccharide and polyethylene glycol (PEG) were added to prepare the experimental granules. The best matrix gelling granule was SUC-GEL. When xylitol (XYL), sorbitol (SOR) and maltitol (MAL) were added, elasticity was improved, and PEG improved the granule's water absorption behavior, which is an important element involved in gelation. The best granules were prepared by selecting SUC-GEL as the matrix and adding a small amount of PEG and XYL in amounts equal to that of SUC-GEL.

Investigation of oral preparation that is expected to improve medication administration: Preparation and evaluation of tablet using ι-Carrageenan: Part 2
熊川さくら; 伊東育己
日本薬学会年会要旨集(Web), 2025

Effects of Heated tobacco on Menstrual Pain and Headache and Awareness of Health Hazards of Smoking
Ito Ikumi; Ishii Masakazu
Japanese Journal of Tobacco Control, 20 Aug. 2024, [Reviewed]
Objective: To determine the effects of heated tobacco smoke and odor on menstrual pain and headache and awareness of the health hazards of smoking.

Methods: An Internet-based survey was conducted involving 600 women in their 20s to 40s who had menstrual pain.

Results: A total of 149 respondents complained of menstrual pain only, and 451 complained of both menstrual pain and headache. Of the respondents who complained of both menstrual pain and headache, 170 had migraine headaches, especially menstrually related migraine, and their physical condition was affected by the smoke and odor of heated tobacco, which worsened menstrual pain, headache, cough, phlegm and digestive symptoms such as nausea. On the other hand, most of the respondents did not understand that smoking causes dysmenorrhea, irregular menstruation, etc.

Conclusion: It was possible to clarify that the smoke and odor of heated tobacco adversely affect menstrual pain and headache. On the other hand, awareness of the health hazards of smoking is poor, and awareness of the relationship between smoking and women’s health problems such as menstrual pain and headaches needs to be increased through education and awareness activities., Japan Society for Tobacco Control

Investigation of oral preparation that is expected to improve medication administration: Preparation and evaluation of tablet using ι-Carrageenan
青木真愛; 蛭田りな; 伊東育己
日本薬学会年会要旨集(Web), 2024

Requirements of Pharmacists in Dealing with Headache Patients
Ito Ikumi; Ishii Masakazu
The Journal of Community Pharmacy and Pharmaceutical Sciences, 2024
Migraine is accompanied by severe pain, photophobia, nausea, and vomiting, placing a heavy burden on daily life. However, many patients and consumers with migraine have do not seek medical attention and use over-the-counter drugs at their own discretion. Easy, repeated use of antipyretic analgesics can lead to headaches due to overuse. In recent years, new acute care has been adopted and prophylactic drugs have been administered as prescription drugs. The prophylactic drug dimetotiazine has also been proposed as an over-the-counter drug. As the number of headache treatment options is increasing, the follow-up of patients, including the interictal period, is important. However, there are few cases where pharmacists are consulted. This paper outlines the roles required of pharmacists in the treatment of headaches, such as support for self-medication and self-care, and medical cooperation., Pharmacy Society of Japan

Current status of headache treatment follow-up using tracing reports by pharmacy pharmacists
Ito Ikumi; Ishii Masakazu; Kijima Tamotsu
Japanese Journal of Community Pharmacy, 30 Dec. 2023
To clarify the current status regarding information-gathering from headache patients, the use of tracing reports in daily operations, and consultation recommendations for headache patients, we conducted a questionnaire survey involving the nearest 400 pharmacies (400 pharmacists) from 400 medical institutions where headache specialists certified by the Japanese Headache Society work. The study was conducted by dividing the patients into two groups: “active group” (tracing reports are used or sometimes used) and “passive group” (tracing reports are used infrequently or not used). The results showed that the “active group” included only 60% of all respondents (63/105), but the implementation rate for headache patients was even lower (7/63), indicating that headache was not recognized as a disease necessitating the use of tracing reports. The “active group” was also more active in recommending medical examinations, but only verbally and not in writing. The rate of interviews with headache patients about the appropriate use of OTC drugs, acute care drugs, and side effects of triptans was low, suggesting that the patients' problems may have been overlooked. These may provide clues to promote medical cooperation., The Japanease Society of Cmmunity Pharmacy

頭痛患者に対する健康サポート薬局の薬剤師による生活指導の実態調査
Oct. 2023

女性における加熱式タバコによる頭痛の実態—The actual condition of headache caused by heated tobacco products in women
Sep. 2023

天候や気圧変化による頭痛と五苓散の使用に関する調査
Jun. 2023

頭痛患者の運動習慣が頭痛に与える影響　　　　　　　　　　　　　　　
Jun. 2023

健康サポート薬局の待合室の光環境に関する調査 頭痛患者と光環境　　　　　　　　　　　　　　　
Jun. 2023

Issues of counseling sales by pharmacists in the OTC conversion of dimethothiazine, a prophylactic drug for headache
伊東育己; 石井正和
日本薬学会年会要旨集(Web), 2023

Issues in Counseling Sales by Pharmacists in the OTC Conversion of Dimetotiazine, a Prophylactic Drug for Headache
伊東育巳; 石井正和
Progress in Medicine, 2023

Heated tobacco products-induced headache in people with migraine with osmophobia: Internet questionnaire survey
Ishii Masakazu; Katoh Hirotaka; Ito Ikumi
Japanese Journal of Tobacco Control, 28 Dec. 2022
Japan Society for Tobacco Control

Survey of headaches caused by heated tobacco products in patients with headache
Ishii Masakazu; Katoh Hirotaka; Ito Ikumi
Japanese Journal of Tobacco Control, 07 Nov. 2022
Japan Society for Tobacco Control

ジェネリック医薬品の生物学的同等性を迅速予測
2022

Investigation of Oral Preparation That Is Expected to Improve Medication Administration: Preparation and Evaluation of Oral Gelling Tablet Using Sodium Alginate
Ito Ikumi; Ito Akihiko; Unezaki Sakae
YAKUGAKU ZASSHI, 2017
The Pharmaceutical Society of Japan