Apr. 2025

Chemometric Approach for Discriminating the Volatile Profile of Cooked Glutinous and Normal-Amylose Rice Cultivars from Representative Japanese Production Areas Using GC × GC-TOFMS
Takayoshi Tanaka; Junhan Zhang; Shuntaro Isoya; Tatsuro Maeda; Kazuya Hasegawa; Tetsuya Araki
Foods, 06 Aug. 2025, [Reviewed], [Invited]
Cooked-rice aroma strongly affects consumer choice, yet the chemical traits distinguishing glutinous rice from normal-amylose japonica rice remain underexplored because earlier studies targeted only a few dozen volatiles using one-dimensional gas chromatography–mass spectrometry (GC-MS). In this study, four glutinous and seven normal Japanese cultivars were cooked under identical conditions, their headspace volatiles trapped with MonoTrap and qualitatively profiled by comprehensive GC × GC-TOFMS. The two-dimensional platform resolved 1924 peaks—about ten-fold previous coverage—and, together with hierarchical clustering, PCA, heatmap visualization and volcano plots, cleanly separated the starch classes (78.3% cumulative PCA variance; Euclidean distance > 140). Volcano plots highlighted 277 compounds enriched in the glutinous cultivars and 295 in Koshihikari, including 270 compounds that were not previously documented in rice. Normal cultivars were dominated by ethers, aldehydes, amines and other nitrogenous volatiles associated with grainy, grassy and toasty notes. Glutinous cultivars showed abundant ketones, furans, carboxylic acids, thiols, steroids, nitro compounds, pyrroles and diverse hydrocarbons and aromatics, yielding sweeter, fruitier and floral accents. These results expand the volatile library for japonica rice, provide molecular markers for flavor-oriented breeding and demonstrate the power of GC × GC-TOFMS coupled with chemometrics for grain aroma research.

Olfactory Receptor Expression Profiles in Clear Cell Renal Cell Carcinoma Reveal Potential Diagnostic and Prognostic Markers
Kazuya Hasegawa; Yuya Yamaguchi
05 Jan. 2025
Abstract

Background

Olfactory receptors (ORs) are G protein-coupled receptors that are aberrantly expressed in various cancers, including clear cell renal cell carcinoma (KIRC). However, the roles of ORs in KIRC are unknown. This study aimed to comprehensively analyze the expression profiles of OR genes in KIRC and evaluate their potential as diagnostic and prognostic biomarkers.

Methods

We analyzed RNA-seq data from The Cancer Genome Atlas KIRC dataset, which contains 72 normal and 530 tumor samples. We selected OR genes with median transcripts per million (TPM) values of 1 or higher in at least one group (normal or tumor). Differential expression analysis was performed using the Student’s t-test or Wilcoxon rank-sum test. The diagnostic potential of OR genes was evaluated using receiver operating characteristic (ROC) curve analysis. Kaplan-Meier analysis was employed to assess the association between OR gene expression and patient survival. Sex-based differences in OR gene expression were also examined.

Results

We identified 11 OR genes with significant changes in KIRC expression. Among them, OR2A4, OR51E1, and OR7E14P showed high diagnostic performance, with AUC values of 0.951, 0.924, and 0.910, respectively. Combining these three genes improved the AUC to 0.972. High OR2A20P expression was significantly associated with poorer prognosis, whereas high OR7E7P expression was associated with better prognosis. We also found sex-based differences in the expression of OR2A7, OR2I1P, and OR7E14P, with females exhibiting significantly higher expression.

Conclusions

Our findings suggest that ORs, especially OR2A4, OR51E1, and OR7E14P, could serve as potential diagnostic markers for KIRC. OR2A20P and OR7E7P may represent promising prognostic markers. The observed sex-based differences in OR gene expression highlight the need for personalized treatment of KIRC. Further studies are warranted to validate these findings and elucidate the functional roles of ORs in the pathogenesis of KIRC.

Evaluation of 3β-hydroxysteroid dehydrogenase activity using progesterone and androgen receptors-mediated transactivation.
Takashi Yazawa; Yugo Watanabe; Yuko Yokohama; Yoshitaka Imamichi; Kazuya Hasegawa; Ke-Ichi Nakajima; Takeshi Kitano; Takanori Ida; Takahiro Sato; Mohammad Sayful Islam; Akihiro Umezawa; Satoru Takahashi; Yasuhito Kato; Sharmin Jahan; Jun-Ichi Kawabe
Frontiers in endocrinology, 2024, [Reviewed]
3β-Hydroxysteroid dehydrogenases (3β-HSDs) catalyze the oxidative conversion of delta (5)-ene-3-beta-hydroxy steroids and ketosteroids. Human 3β-HSD type 2 (HSD3B2) is predominantly expressed in gonadal and adrenal steroidogenic cells for producing all classes of active steroid hormones. Mutations in HSD3B2 gene cause a rare form of congenital adrenal hyperplasia with varying degree of salt wasting and incomplete masculinization, resulting from reduced production of corticoids and androgens. Therefore, evaluation of the HSD3B2 enzymatic activity in both pathways for each steroid hormone production is important for accurately understanding and diagnosing this disorder. Using progesterone receptor (PR)- and androgen receptor (AR)-mediated transactivation, we adapted a method that easily evaluates enzymatic activity of HSD3B2 by quantifying the conversion from substrates [pregnenolone (P5) and dehydroepiandrosterone (DHEA)] to (progesterone and androstenedione). HEK293 cells were transduced to express human HSD3B2, and incubated medium containing P5 or DHEA. Depending on the incubation time with HSD3B2-expressing cells, the culture media progressively increased luciferase activities in CV-1 cells, transfected with the PR/AR expression vector and progesterone-/androgen-responsive reporter. Culture media from human and other mammalian HSD3B1-expressing cells also increased the luciferase activities. HEK293 cells expressing various missense mutations in the HSD3B2 gene revealed the potential of this system to evaluate the relationship between the enzymatic activities of mutant proteins and patient phenotype.

Analyses of Molecular Characteristics and Enzymatic Activities of Ovine HSD17B3
Mohammad Sayful Islam; Junsuke Uwada; Junki Hayashi; Kei-ichiro Kikuya; Yuki Muranishi; Hiroyuki Watanabe; Kazuhide Yaegashi; Kazuya Hasegawa; Takanori Ida; Takahiro Sato; Yoshitaka Imamichi; Takeshi Kitano; Yoshimichi Miyashiro; Rafiqul Islam Khan; Satoru Takahashi; Akihiro Umezawa; Nobuo Suzuki; Toshio Sekiguchi; Takashi Yazawa
Animals, 30 Sep. 2021, [Reviewed]
17β-hydroxysteroid dehydrogenase type 3 (HSD17B3) converts androstenedione (A4) into testosterone (T), which regulates sex steroid production. Because various mutations of the HSD17B3 gene cause disorder of sex differentiation (DSD) in multiple mammalian species, it is very important to reveal the molecular characteristics of this gene in various species. Here, we revealed the open reading frame of the ovine HSD17B3 gene. Enzymatic activities of ovine HSD17B3 and HSD17B1 for converting A4 to T were detected using ovine androgen receptor-mediated transactivation in reporter assays. Although HSD17B3 also converted estrone to estradiol, this activity was much weaker than those of HSD17B1. Although ovine HSD17B3 has an amino acid sequence that is conserved compared with other mammalian species, it possesses two amino acid substitutions that are consistent with the reported variants of human HSD17B3. Substitutions of these amino acids in ovine HSD17B3 for those in human did not affect the enzymatic activities. However, enzymatic activities declined upon missense mutations of the HSD17B3 gene associated with 46,XY DSD, affecting amino acids that are conserved between these two species. The present study provides basic information and tools to investigate the molecular mechanisms behind DSD not only in ovine, but also in various mammalian species.

Potential Genetic Contributions of the Central Nervous System to a Predisposition to Elite Athletic Traits: State-of-the-Art and Future Perspectives
Hiroya Kitazawa; Kazuya Hasegawa; Daichi Aruga; Masashi Tanaka
Genes, 05 Mar. 2021, [Reviewed]
Recent remarkable advances in genetic technologies have allowed for the identification of genetic factors potentially related to a predisposition to elite athletic performance. Most of these genetic variants seem to be implicated in musculoskeletal and cardiopulmonary functions. Conversely, it remains unclear whether functions of the central nervous system (CNS) genetically contribute to elite athletic traits, although the CNS plays critical roles in exercise performance. Accumulating evidence has highlighted the emerging implications of CNS-related genes in the modulation of brain activities, including mental performance and motor-related traits, thereby potentially contributing to high levels of exercise performance. In this review, recent advances are summarized, and future research directions are discussed in regard to CNS-related genes with potential roles in a predisposition to elite athletic traits.

Inhibitory effects of curcuminoids on dexamethasone-induced muscle atrophy in differentiation of C2C12 cells
Sani A; Hasegawa K; Yamaguchic Y; Panichayupakaranant P; Pengjam
Phytomedicine Plus, Feb. 2021, [Reviewed]

Differential roles of VPS and RAAS in water homeostasis and a risk for kidney dysfunction in rats undergoing rapid fasting/dehydration with regular exercise
KazuyA Hasegawa; Yuya Yamaguchi; Masashi Tanaka
Physiological Reports, Jan. 2021, [Reviewed]

High-dose pyruvate treatment alters skeletal muscle differentiation and expression of inflammation-related genes
Hasegawa K; Yamaguchi Y; Pengjam Y
BioRxiv, Sep. 2020
ABSTRACT

Pyruvic acid therapy is used for various diseases, but the therapeutic effect decreases at high doses. The molecular mechanism of high-dose pyruvate is not well understood. The purpose of this study was to identify the effects of high dose pyruvate addition on skeletal muscle using C2C12. The gene expression profile for the GSE5497 dataset was taken from the Gene Expression Omnibus database. GEO2R was used to identify specifically expressed genes (DEGs). Functional analysis and pathway enrichment analysis of DEG were performed using the DAVID database. The protein-protein interaction (PPI) network was built in the STRING database and visualized using Cytoscape. GO analysis showed that up-regulated DEG was primarily involved in angiogenesis, cell adhesion, and inflammatory response. We also showed that down-regulated DEG is involved in the regulation of muscle contraction, skeletal muscle fiber development. In addition, the upregulated KEGG pathway of DEG included Rheumatoid arthritis, Chemokine signaling pathway, and Cytokine-cytokine receptor interaction. Downregulated DEG included Calcium signaling pathway, hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy, Neuroactive ligand-receptor interaction, and Cardiac muscle contraction. Further, analysis of two modules selected from the PPI network showed that high-dose pyruvate exposure to C2C12 was primarily associated with muscle contraction, muscle organ morphogenesis, leukocyte chemotaxis, and chemokine activity. In conclusion, High-dose pyruvate treatment of C2C12 was found to be associated with an increased inflammatory response and decreased skeletal muscle formation. However, further studies are still needed to verify the function of these molecules at high doses of pyruvate.

A new action of peptide hormones for survival in a low-nutrient environment.
Takahiro Sato; Takahiro Nemoto; Kazuya Hasegawa; Takanori Ida; Masayasu Kojima
Endocrine journal, 28 Nov. 2019, [Reviewed]
Malnutrition occurs when nutrient intake is too low for any reason and occurs regardless of gender or age. Therefore, besides loss of eating or digestive functionality due to illness, malnutrition can occur when a healthy individual undergoes an extreme diet and biases their nutrition, or when athletes exerts more energy than they can replenish through food. It has recently been reported that in Japan, the mortality rate of leaner individuals is equal to or higher than that of obese people. It is important to understand what homeostatic maintenance mechanism is behind this when the body is under hypotrophic conditions. Such mechanisms are generally endocranially controlled. We address this fundamental concern in this paper by focusing on peptide hormones. We introduce a mechanism for survival in a malnourished state via the regulation of food intake and temperature. Additionally, we will discuss the latest findings and future prospects for research on changes in the endocrine environment associated with malnutrition associated with exercise. We also review changes in next-generation endocrine environments when caused by malnutrition brought on by dieting.

サルコペニアの発症および進展における炎症のかかわり　　　　　　　　　　　　　　　
Dec. 2018, [Reviewed]

Influence of food texture on energy metabolism and adiposity in male rats.
Wanxin Han; Maiko Utoyoma; Sayaka Akieda-Asai; Ayano Hidaka; Chihiro Yamada; Kazuya Hasegawa; Hiroyuki Nunoi; Yukari Date
Experimental physiology, Oct. 2018, [Reviewed]
NEW FINDINGS: What is the central question of this manuscript? What is the effect of food texture on fat accumulation, lipogenesis and proinflammatory factors in the adipose tissue and on energy balance in male rats? What is the main finding and its importance? Calorie intake and fat accumulation in rats fed soft pellets ad libitum increased, but their body weight did not. The data suggest that, even when BMI is normal, frequent consumption of soft food may contribute to the development of lifestyle-related diseases. ABSTRACT: Dietary factors such as food texture are known to affect feeding behaviour and energy metabolism. We recently found that rats fed soft pellets (SPs) on a 3 h restricted feeding schedule showed glucose intolerance, insulin resistance with disruption of insulin signalling, and hyperplasia of pancreatic β-cells, even though there were no differences in energy intake and body weight between rats fed control pellets (CPs) and rats fed SPs. We investigated the effect of food texture on fat accumulation, lipogenesis and proinflammatory factors in the mesenteric fat, as well as on energy balance in male rats fed CPs or SPs. We used 7-week-old Wistar rats that were randomly divided into two groups, ad libitum fed either CPs or SPs for 27 weeks. Body weight and calorie intake were monitored once a week throughout the experiment. The calorie intake, lipogenesis and fat accumulation of the rats fed SPs increased, whereas their body weight did not. Additionally, SP rats used their fat mainly as a source of energy and increased their energy expenditure. Our data suggest that the habit of frequently eating soft food causes visceral fat accumulation without an increase in body weight. Further investigations using soft-textured foods could lead to the development of appropriate interventions for non-overweight patients with lifestyle-related diseases.

Characterization of inflammatory gene expression and chemotaxis of macrophages expressing guanylin and guanylyl cyclase-C　　　　　　　　　　　　　　　
Hasegawa K; Akieda-Asai S; Date Y
American Journal of Life Sciences, May 2015, [Reviewed]

Guanylin-Guanylyl cyclase-C signaling in macrophages regulates mesenteric fat inflammation induced by high-fat diet.
Kazuya Hasegawa; Sayaka Akieda-Asai; Yurie Fujii; Cho-Rong Bae; Masahiro Yasuda; Yukari Date
Endocrine journal, 2015, [Reviewed]
Guanylin (Gn), a bioactive peptide, and its receptor, guanylyl cyclase-C (GC-C), are primarily present in the intestine and maintain homeostasis in body fluids. Recently, rats whose macrophages overexpress Gn and GC-C were found to be resistant to diet-induced obesity. Considering that obesity is strongly related to a chronic inflammatory state in white adipose tissues, it is possible that Gn-GC-C macrophages contribute to the regulation of inflammation. In the present study, we investigated the inflammatory state of mesenteric fat in rats transgenic for both Gn and GC-C (double-transgenic [dTg] rats) by evaluating the levels of cyclic guanosine monophosphate (cGMP), a second messenger of Gn-GC-C, cGMP-dependent protein kinase (PKG), and phosphorylated vasodilator-stimulated phosphoprotein (VASP), a target protein of PKG. The levels of cGMP in dTg rats was higher than in WT rats fed the same diet. Although there were no significant differences in levels of PKG and phosphorylated VASP between WT and dTg rats fed a standard diet (STD), these levels in dTg rats fed a high fat diet (HFD) were markedly increased compared with levels in HFD WT rats. Furthermore, mRNA levels of proinflammatory factors in mesenteric fat were lower in HFD dTg rats than in HFD WT rats and were similar to levels in STD WT and dTg rats. These results indicate that the Gn-GC-C system in macrophages regulates the cGMP-PKG-VASP pathway and controls obesity through the downregulation of proinflammatory factors.

The short-term effects of soft pellets on lipogenesis and insulin sensitivity in rats.
Cho-Rong Bae; Kazuya Hasegawa; Sayaka Akieda-Asai; Yurie Kawasaki; Youn-Soo Cha; Yukari Date
Preventive nutrition and food science, Sep. 2014, [Reviewed]
The purpose of the present study was to investigate the short-term effects of a 12-day, soft pellet (SP) diet with a 3-h restricted feeding schedule on caloric intake, body weight, lipid metabolism, and insulin sensitivity. Glucose and insulin levels were measured pre-, mid-, and post-feeding. The SP rats exhibited postprandial hyperglycemia compared to rats fed control pellets (CP). The insulin response of SP rats during a meal was significantly higher than that of CP rats. There were no significant differences in the hepatic triacylglycerol contents and lipogenesis gene mRNA levels of SP and CP rats. However, the hepatocytes of SP rats were slightly hypertrophic. In addition, histological analysis revealed that the pancreases of SP rats had more islet areas than those of CP rats. This study demonstrated that feeding an SP-only diet for 12 days induces glucose intolerance, suggesting that the consumption of absorbable food, like a soft diet, may trigger glucose metabolism insufficiency and lead to life-threatening diseases.

Possible involvement of food texture in insulin resistance and energy metabolism in male rats
Cho-Rong Bae; Kazuya Hasegawa; Sayaka Akieda-Asai; Yurie Kawasaki; Kazuyo Senba; Youn-Soo Cha; Yukari Date
JOURNAL OF ENDOCRINOLOGY, Jul. 2014, [Reviewed]

Role of the neural pathway from hindbrain to hypothalamus in interaction of GLP1 and leptin in rats
Sayaka Akieda-Asai; Paul-Emile Poleni; Kazuya Hasegawa; Yukari Date
JOURNAL OF ENDOCRINOLOGY, Feb. 2014, [Reviewed]

Metabolic features of rats resistant to a high-fat diet
S. Akieda-Asai; S. Koda; M. Sugiyama; K. Hasegawa; M. Furuya; M. Miyazato; Y. Date
OBESITY RESEARCH & CLINICAL PRACTICE, Jul. 2013, [Reviewed]

Rapid induction of REDD1 expression by endurance exercise in rat skeletal muscle
Taro Murakami; Kazuya Hasegawa; Mariko Yoshinaga
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Feb. 2011, [Reviewed]

オーファン受容体に対する内因性リガンドの探索と応用
2023

東南アジア産植物からの加齢性骨格筋委縮抑制成分の探索
Dec. 2022, [Invited]
Lead, Corresponding

摂食・飲水制限による急速減量におけるタンパク質分解
Jun. 2021, [Invited]
Lead, Corresponding

急速減量におけるタンパク質分解
Mar. 2021, [Invited]
Lead, Corresponding

アカデミックキャリアについて　　　　　　　　　　　　　　　
15 Jul. 2025, [Invited]

ライフステージ形成におけるホルモンの役割　　　　　　　　　　　　　　　
28 Mar. 2024, [Invited]

Study the effects of Asian herbal medicines for the treatment of sarcopenia patient　　　　　　　　　　　　　　　
Sani A; Hasegawa K; Yamaguchi Y; Panichayupakaranant P; Pengjam Y
the 6th CDD International Conference 2020, Thailand, Sep. 2020

ホルモンに着目した急速減量における水分代謝応答の解明　　　　　　　　　　　　　　　
Sep. 2019

体重階級制競技における急速減量による内分泌代謝応答の解析　　　　　　　　　　　　　　　
Aug. 2019

骨格筋タンパク代謝を制御する植物由来成分の同定　　　　　　　　　　　　　　　
Jan. 2019

管理栄養士養成校での研究環境整備とホルモン研究　　　　　　　　　　　　　　　
Dec. 2017

ラットを用いた運動刺激によるタンパク質合成の抑制メカニズムに関する研究　　　　　　　　　　　　　　　
Oct. 2017, [Invited]

グアニリンおよび GC-C による肥満制御機構に関する研究　　　　　　　　　　　　　　　
Sep. 2017, [Invited]

ラットへの軟食自由摂食によるエネルギー代謝バランスと内臓脂肪蓄積　　　　　　　　　　　　　　　
Apr. 2016

Possible involvement of food texture in insulin resistance and energy metabolism in male rats　　　　　　　　　　　　　　　
Mar. 2016, [Invited]

抗肥満ラットにおけるGuanylin/GC-Cの作用　　　　　　　　　　　　　　　
Oct. 2015

延髄―視床下部の神経路遮断によるエネルギー代謝への影響　　　　　　　　　　　　　　　
Oct. 2015

Soft diet自由摂食ラットにおける代謝バランスと内臓脂肪蓄積　　　　　　　　　　　　　　　
Oct. 2015

マクロファージのグアニリン/GC-Cが炎症性サイトカイン発現と走化性に与える影響　　　　　　　　　　　　　　　
Oct. 2015

グアニリン/グアニル酸シクラーゼC発現マクロファージの慢性炎症制御機構の解析　　　　　　　　　　　　　　　
Jul. 2015

グアニリン/グアニル酸シクラーゼC発現マクロファージの機能特性　　　　　　　　　　　　　　　
May 2015

マクロファージにおけるグアニリン/グアニル酸シクラーゼCの発現調節機構の解明　　　　　　　　　　　　　　　
Apr. 2015

肥満抵抗性に関与するグアニリン/グアニル酸シクラーゼC発現マクロファージの炎症制御機構の解析　　　　　　　　　　　　　　　
Apr. 2015

軟らかい食物の短期間摂取がインスリン抵抗性に及ぼす影響　　　　　　　　　　　　　　　
Oct. 2014

食物の性状の違いがエネルギーバランスおよびインスリン抵抗性に及ぼす影響　　　　　　　　　　　　　　　
Jul. 2014

グアニリン/GC-C システムの肥満抵抗性に関する研究　　　　　　　　　　　　　　　
Apr. 2014

ソフトペレット（軟食）給餌による肥満を伴わない２型糖尿病モデルラットの解析　　　　　　　　　　　　　　　
Apr. 2014

肥満を伴わない2型糖尿病モデル動物におけるインスリンシグナル分子とmicroRNA-33に関する研究　　　　　　　　　　　　　　　
Nov. 2013

肥満抵抗性ラットの腸間膜脂肪組織および肝臓における炎症性マーカーの検討　　　　　　　　　　　　　　　
Nov. 2013

レプチンと摂食抑制消化管ホルモンとの相乗効果に関する分子機構の解明　　　　　　　　　　　　　　　
Oct. 2013

肥満抵抗性に関与するグアニリン/グアニル酸シクラーゼC発現マクロファージの特性　　　　　　　　　　　　　　　
Oct. 2013

過食・肥満を伴わずインスリン抵抗性を示すソフトペレット（軟食）給餌ラットの解析　　　　　　　　　　　　　　　
Oct. 2013

持久運動による骨格筋のREDD1発現の増大とmTORC1経路の抑制　　　　　　　　　　　　　　　
Sep. 2013

Over expressions of guanylin and GC-C in rat mesenteric macrophages are involved in resistance to high-fat diet　　　　　　　　　　　　　　　
Jul. 2013

高脂肪食耐性ラットにおけるグアニリンファミリーの役割　　　　　　　　　　　　　　　
Apr. 2013

マクロファージのグアニリン/グアニル酸シクラーゼCによる肥満制御機構に関する研究.　　　　　　　　　　　　　　　
Apr. 2013

肥満抵抗性を示すGuanylin/GC-Cダブルトランスジェニックラットの腸間膜脂肪組織および肝臓における炎症性マーカーの検討　　　　　　　　　　　　　　　
Apr. 2013

マクロファージのグアニリン/GC-Cによる脂肪滴蓄積制御機構　　　　　　　　　　　　　　　
Mar. 2013

肥満抵抗性ラットから見出した生理活性物質による脂肪滴蓄積抑制作用　　　　　　　　　　　　　　　
Nov. 2012

肥満抵抗性ラットの炎症性マーカーの検討　　　　　　　　　　　　　　　
Nov. 2012

グアニリン/グアニル酸シクラーゼCダブルトランスジェニックラットは肥満抵抗性を示す　　　　　　　　　　　　　　　
Oct. 2012

グルカゴン様ペプチド-1(GLP-1)とレプチンの同時投与による摂食抑制効果に関する分子機構　　　　　　　　　　　　　　　
Sep. 2012

高脂肪食耐性ラット特異的発現遺伝子による脂肪滴蓄積抑制　　　　　　　　　　　　　　　
Sep. 2012

持久運動による骨格筋におけるREDD1発現の増大とmTORC1経路の抑制　　　　　　　　　　　　　　　
Nov. 2011

Endurance exercise induces REDD1 expression in rat skeletal muscle　　　　　　　　　　　　　　　
Sep. 2011

Exercise downregulates mTORC1 pathway through REDD1 expression in rat skeletal muscle　　　　　　　　　　　　　　　
May 2011

持久運動による腓腹筋におけるREDD1発現の増大　　　　　　　　　　　　　　　
May 2011

Nov. 2022 - Present
日本生理学会　　　　　　　　　　　　　　　

Jul. 2019 - Present
THE JAPANESE SOCIETY OF PHYSICAL FITNESS AND SPORTS MEDICINE　　　　　　　　　　　　　　　

Aug. 2016 - Present
JAPAN SOCIETY FOR THE STUDY OF OBESITY　　　　　　　　　　　　　　　

Aug. 2016 - Present
The Japan Endocrine Society　　　　　　　　　　　　　　　

Physiological effects of odorants produced in the body by exercise via organ olfactory receptors
Grant-in-Aid for Challenging Research (Exploratory)
Teikyo Heisei University
Jun. 2024 - Mar. 2027

Fundamental research in the development of mechanism elucidation and suppression of acute kidney injury caused by rapid weight loss
Grant-in-Aid for Scientific Research (B)
Teikyo Heisei University
Apr. 2023 - Mar. 2027

Search for food components with sarcopenia preventive effect focus on hormones
Grant-in-Aid for Early-Career Scientists
Morioka College
Apr. 2020 - Mar. 2024

体重階級制競技における急速減量が骨格筋および消化管のタンパク質代謝に与える影響
Apr. 2017 - Mar. 2020

急速減量による水分代謝応答の分子機構の解明
Apr. 2017 - Mar. 2018

岩手県立盛岡南高校 保健講話講師　　　　　　　　　　　　　　　
lecturer
07 May 2019

岩手県立盛岡南高校 保健講話講師　　　　　　　　　　　　　　　
lecturer
07 May 2018