Mariko Muta
| Faculty of Health and Medical Science,Department of Health and Dietetics | Professor |
| Graduate School of Health Sciences,Doctoral Program in Health Sciences | Professor |
| Graduate School of Health Sciences,Master's and Doctoral Programs in Health and Dietetics | Professor |
Last Updated :2025/10/07
■Researcher basic information
Field Of Study
■Career
Career
- Apr. 2020 - Present
Teikyo Heisei University, Department of Health and Dietetics, Faculty of Health and Medical Science, Prifessor - Apr. 2008 - Mar. 2020
Teikyo Heisei University, Faculty of Health and Medical Science, Department of Health and Dietetics - Apr. 2010 - Mar. 2017
Japan University of Health Sciences - Oct. 2007 - Mar. 2014
Kyoto University - Jun. 2006 - Mar. 2008
Kyoritsu University of Pharmacy
Educational Background
- Apr. 2001 - Mar. 2004, Kyoritsu University of Pharmacy
- Apr. 2001 - Mar. 2004, Kyoritsu University of Pharmacy, Graduate School, Division of Pharmaceutical Sciences, Doctor
- Apr. 1999 - Mar. 2001, Kyoritsu University of Pharmacy
- Apr. 1999 - Mar. 2001, Kyoritsu University of Pharmacy, Graduate School, Division of Pharmaceutical Sciences, Master
- Apr. 1980 - Mar. 1984, Japan Women's University, Faculty of Human Sciences and Design, Department of Food and Nutrition
- Apr. 1980 - Mar. 1984, Japan Women's University, Faculty of Home Economics
■Research activity information
Paper
- Importance of nutrition educator in Japanese elementary school education
MUTA Mariko
Mar. 2017, [Reviewed] - Basic Fibroblast Growth Factor Is Essential to Maintain Endothelial Progenitor Cell Phenotype in TR-BME2 Cells
Yoshimichi Sai; Tomohiro Nishimura; Mariko Muta; Hisashi Iizasa; Takashi Miyata; Emi Nakashima
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Apr. 2014, [Reviewed] - Genome-wide copy number analysis in primary breast cancer
Takayuki Ueno; Mitsuru Emi; Hidenori Sato; Noriko Ito; Mariko Muta; Katsumasa Kuroi; Masakazu Toi
EXPERT OPINION ON THERAPEUTIC TARGETS, Mar. 2012, [Reviewed] - Genome-wide copy number analysis in primary breast cancer
Takayuki Ueno; Mitsuru Emi; Hidenori Sato; Noriko Ito; Mariko Muta; Katsumasa Kuroi; Masakazu Toi
EXPERT OPINION ON THERAPEUTIC TARGETS, Mar. 2012, [Reviewed] - Roles of TauT and system A in cytoprotection of rat syncytiotrophoblast cell line exposed to hypertonic stress
T. Nishimura; Y. Sai; J. Fujii; M. Muta; H. Iizasa; M. Tomi; M. Deureh; N. Kose; E. Nakashima
PLACENTA, Nov. 2010, [Reviewed] - Effect of Low-Dose Paclitaxel and Docetaxel on Endothelial Progenitor Cells
Mariko Muta; Tomonori Yanagawa; Yoshimichi Sai; Shigehira Saji; Eiji Suzuki; Tomoyuki Aruga; Katsumasa Kuroi; Gaku Matsumoto; Masakazu Toi; Emi Nakashima
ONCOLOGY, 2009, [Reviewed] - A nonfucosylated anti-HER2 antibody augments antibody-dependent cellular cytotoxicity in breast cancer patients
Eiji Suzuki; Rinpei Niwa; Shigehira Saji; Mariko Muta; Makiko Hirose; Shigeru Iida; Yukimasa Shiotsu; Mitsuo Satoh; Kenya Shitara; Masahide Kondo; Masakazu Toi
CLINICAL CANCER RESEARCH, Mar. 2007, [Reviewed] - Altered expression of basement membrane-related molecules in rat brain pericyte, endothelial, and astrocyte cell lines after transforming growth factor-beta 1 treatment
Noriko Kose; Tomoko Asashima; Mariko Muta; Hisashi Iizasa; Yoshimichi Sai; Tetsuya Terasaki; Emi Nakashima
DRUG METABOLISM AND PHARMACOKINETICS, 2007, [Reviewed] - Alterd Expression of basement membrane-related molecules in rat brain pericyte, endothelial, and astrocyte cell lines after transforming growth factor-beta1 treatment.
Kose N; Asashima T; Muta M; Iizasa H; Sai Y; Terasaki T; Nakashima E
Drug Metab Pharmacokinet., 2007, [Reviewed]
The basement membrane at the blood-brain barrier (BBB) plays important roles in maintaining the structure and function of capillary vessels. The BBB is constructed from endothelial cells, astrocytes and pericytes, but their interactions in the formation or maintenance of basement membrane have not been established. Transforming growth factor-β1 (TGF-β1) is known to increase fibronectin in brain capillary basement membrane with deposition of β-amyloid. We previously reported that the mRNA level of α-smooth muscle actin in a brain capillary pericyte cell line TR-PCT1 was increased by treatment with TGF-β1. In this study, expression of mRNAs encoding basement membrane-related molecules in TR-PCT1, a rat endothelial cell line TR-BBB13, and a type 2 astrocyte cell line TR-AST4 was evaluated by RT-PCR. The effects of TGF-β1 on expression of basement membrane-related genes in these cell lines were also examined. Fibronectin, MMP-9, tPA, TIMP-1, and PAI-l in TR-PCT1 were higher than in TR-BBB13 and TR-AST4. In TR-PCT1 treated with TGF-β1, collagen type IV, PAI-1, and MMP-9 were increased, and TIMP-2 was reduced. The change in PAI-1 mRNA was faster than those in MMP-9, TIMP-2, collagen type IV mRNAs. These results suggest that pericytes may be key cells in the maintenance of the basement membrane at the BBB. - Tumor size significantly correlates with postoperative liver metastases and COX-2 expression in patients with resectable pancreatic cancer
Gaku Matsumoto; Mariko Muta; Koji Tsuruta; Shinichiro Horiguchi; Katsuyuki Karasawa; Atsutake Okamoto
PANCREATOLOGY, 2007, [Reviewed] - Mechanical analysis of tumor growth regression by the cyclooxygenase-2 inhibitor, DFU, in a Walker256 rat tumor model: Importance of monocyte chemoattractant protein-1 modulation
M Muta; G Matsumoto; E Nakashima; M Toi
CLINICAL CANCER RESEARCH, Jan. 2006, [Reviewed] - Enhancement of the caspase-independent apoptotic sensitivity of pancreatic cancer cells by DHMEQ, an NF-kappa B inhibitor
G Matsumoto; M Muta; K Umezawa; T Suzuki; K Misumi; K Tsuruta; A Okamoto; M Toi
INTERNATIONAL JOURNAL OF ONCOLOGY, Nov. 2005, [Reviewed] - Targeting of nuclear factor kappa B pathways by dehydroxymethylepoxyquinomicin, a novel inhibitor of breast carcinomas: Antitumor and antiangiogenic potential in vivo
G Matsumoto; J Namekawa; M Muta; T Nakamura; H Bando; K Tohyama; M Toi; K Umezawa
CLINICAL CANCER RESEARCH, Feb. 2005, [Reviewed] - DFU, a selective COX-2 inhibitor, suppresses MCF-7 xenograft tumor growth in mice
G Matsumoto; MA Rahman; M Muta; T Nakamura; H Bando; S Saji; K Tsuruta; A Okamoto; M Toi
ONCOLOGY REPORTS, Aug. 2004, [Reviewed] - Modulation of thymidine phosphorylase by neoadjuvant chemotherapy in primary breast cancer
M Toi; H Bando; S Horiguchi; M Takada; A Kataoka; T Ueno; S Saji; M Muta; N Funata; S Ohno
BRITISH JOURNAL OF CANCER, Jun. 2004, [Reviewed] - Study of cancer gene therapy using IL-12-secreting endothelial progenitor cells in a rat solid tumor model
M Muta; G Matsumoto; K Hiruma; E Nakashima; M Toi
ONCOLOGY REPORTS, Nov. 2003, [Reviewed] - Impact of vasculogenesis on solid tumor growth in a rat model
M Muta; G Matsumoto; K Hiruma; S Saji; E Nakashima; M Toi
ONCOLOGY REPORTS, Sep. 2003, [Reviewed] - Survival benefit of KRN7000 immune therapy in combination with TNP470 in hamster liver metastasis model of pancreatic cancer
G Matsumoto; S Nagai; M Muta; K Tsuruta; A Okamoto; M Toi
ONCOLOGY REPORTS, Sep. 2003, [Reviewed] - Immunohistochemical analysis of estrone sulfatase and aromatase in human breast cancer tissues
Y Yamamoto; JI Yamashita; M Toi; M Muta; S Nagai; N Hanai; A Furuya; Y Osawa; S Saji; M Ogawa
ONCOLOGY REPORTS, Jul. 2003, [Reviewed] - Expression of macrophage migration inhibitory factor in human breast cancer: Association with nodal spread
H Bando; G Matsumoto; M Bando; M Muta; T Ogawa; N Funata; J Nishihira; M Koike; M Toi
JAPANESE JOURNAL OF CANCER RESEARCH, Apr. 2002, [Reviewed] - Significance of vascular endothelial growth factor (VEGF)/soluble VEGF receptor-1 relationship in breast cancer
M Toi; H Bando; T Ogawa; M Muta; C Hornig; HA Weich
INTERNATIONAL JOURNAL OF CANCER, Mar. 2002, [Reviewed] - Establishment of bone marrow-derived endothelial cell lines from ts-SV40 T-antigen gene transgenic rats
K Hattori; M Muta; M Toi; H Iizasa; M Shinsei; T Terasaki; M Obinata; M Ueda; E Nakashima
PHARMACEUTICAL RESEARCH, Jan. 2001, [Reviewed] - Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer
T Ueno; M Toi; H Saji; M Muta; H Bando; K Kuroi; M Koike; H Inadera; K Matsushima
CLINICAL CANCER RESEARCH, Aug. 2000, [Reviewed] - Significance of membrane type 1 matrix metalloproteinase expression in breast cancer
S Ishigaki; M Toi; T Ueno; H Matsumoto; M Muta; M Koike; M Seiki
JAPANESE JOURNAL OF CANCER RESEARCH, May 1999, [Reviewed] - Significance of membrane type 1 matrix metalloproteinase expression in breast cancer
Shinsuke Ishigaki; Masakazu Toi; Takayuki Ueno; Hiroshi Matsumoto; Mariko Muta; Morio Koike; Motoharu Seiki
Japanese Journal of Cancer Research, 1999, [Reviewed] - Role of MDM2 overexpression in doxorubicin resistance of breast carcinoma
A Suzuki; M Toi; Y Yamamoto; S Saji; M Muta; T Tominaga
JAPANESE JOURNAL OF CANCER RESEARCH, Feb. 1998, [Reviewed]
Lectures, oral presentations, etc.
- 食品群別摂取量と咬合圧・咀嚼能力の関連についての検討~若齢成人を対象として~
22 Aug. 2014 - Potential beneficial effects of ginger on chemotherapy in breast cancer.
Mariko Muta; Takayuki Ueno; Katsumasa Kuroi; Masakazu Toi
The 8th Annual Conference of OOTR, 20 Apr. 2012 - Effects of ginger on cancer chemotherapy
Mariko Muta; Takayuki Ueno; Katsumasa Kuroi; Masakazu Toi
23 Sep. 2010 - Effects of ginger on cancer chemotherapy.
Mariko Muta; Takayuki Ueno; Katsumasa Kuroi; Masakazu Toi
The 6th Annual Conference of OOTR, 26 Feb. 2010 - Effects of paclitaxel and docetaxel on endothelial progenitor cells in a rat tumor model.
2009 - Effects of paclitaxel and docetaxel on endothelial progenitor cells in a rat tumor model.
The 8th Cerebral Vascular Biology International Conference, 2009 - Docetaxel, Paclitaxelの血管内皮前駆細胞への作用と血管新生阻害効果の検討。
26 Jun. 2008 - Inhibition of Vasculogenesis on Endothelial Progenitor Cell Line TR-BME by Docetaxel and Paclitaxel.
2007 - Inhibition of Vasculogenesis on Endothelial Progenitor Cell Line TR-BME by Docetaxel and Paclitaxel.
The 4th Annual Conference of Organisation for Oncology and Translational Research (OOTR), 2007 - 脈管形成が固形腫瘍に及ぼす血管新生促進効果とMCP-1の関与
2005 - 血管内皮前駆細胞の腫瘍特異的集積におけるVEGF, MCP-1の関与
2004 - IL-12遺伝子導入血管内皮前駆細胞の腫瘍特異的集積性と癌治療効果
2003 - Study of cancer gene therapy using IL-12-secreting endothelial progenitor cells in a rat solid tumor model.
2003 - Study of cancer gene therapy using IL-12-secreting endothelial progeitor cells in a rato solid tumor model.
AAPS Annual Meeting and Exposition, 2003 - 脈管形成と免疫による腫瘍増殖の調節
2002 - Tumor-targeting of cell therapy using gene-transfected endothelial progenitor cells.
2002 - Tumor-targeting of cell therapy using gene-transfected endothelial progenitor cells.
The 1st Korea-Japan Joint Symposium on Drug Delivery and Therapy., 2002 - ラット骨髄由来血管内皮前駆細胞株の生体内動態と腫瘍血管新生への関与
2001 - Recruitment of bone marrow-derived endothelial cells to the in vivo malignant tumor by comparison with other organs.
2001 - Recruitment of bone marrow-derived endothelial cells to the in vivo malignant tumor by comparison with other organs.
World Congress of Pharmacy and Pharmaceutical Sciences 2001., 61th International Congress FIP., 2001 - Established of conditionally immortalized endothelial cell lines (TR-BME) derived from rat bone marrow.
2000 - Established of conditionally immortalized endothelial cell lines (TR-BME) derived from rat bone marrow.
Millennial world congress of pharmaceutical sciences., 2000
Affiliated academic society
Research Themes
- がん化学療法時の味覚障害のプロファイルに基づく食事設計
01 Apr. 2019 - 31 Mar. 2023 - トリプトファンバランスに着目した食事による胎児成長支援戦略の構築
Apr. 2018 - Mar. 2021 - がん化学療法時の味覚障害に関する調査研究
Apr. 2016 - Mar. 2019 - ヒト胎盤透過速度プロファイルに基づく合理的な妊娠期食事設計戦略
Apr. 2014 - Mar. 2017 - Study on bone marrow-derived endothelial cells.