Apr. 2013
School of Medicine, University of Tsukuba, Best Tutor Award (Selected by Students)
TAKAHASHI Hideto

2013
Kawaii Memorial Prize
Japan

Apr. 2011
School of Medicine, University of Tsukuba, Best Tutor Award (Selected by Students)
TAKAHASHI Hideto

2003
Prize for Encouragement
Japan

Detection of thyroid cancer among children and adolescents in Fukushima, Japan: a population-based cohort study of the Fukushima Health Management Survey
Hideto Takahashi; Seiji Yasumura; Kunihiko Takahashi; Tetsuya Ohira; Hiroki Shimura; Hitoshi Ohto; Satoru Suzuki; Shinichi Suzuki; Tetsuo Ishikawa; Satoshi Suzuki; Enbo Ma; Masanori Nagao; Susumu Yokoya; Kenji Kamiya
eClinicalMedicine, Sep. 2024

Different trends in suicide rates among foreign residents in Japan and Japanese citizens during the COVID-19 pandemic.
Yuta Taniguchi; Nanako Tamiya; Masao Iwagami; Kazumasa Yamagishi; Atsushi Miyawaki; Rie Masuda; Tomomi Kihara; Jun Komiyama; Hirokazu Tachikawa; Hideto Takahashi; Hiroyasu Iso
International journal for equity in health, 31 Jul. 2024
BACKGROUND: Suicide rates in Japan have increased during the COVID-19 pandemic, and foreign residents may be more vulnerable to mental stress during such crises. Therefore, we aimed to compare the trends in suicide rates during the COVID-19 pandemic between foreign residents and Japanese citizens. METHODS: Vital statistics of Japan data from January 1, 2016 to December 31, 2021 were used to calculate quarterly sex-specific suicide rates for foreign residents and Japanese citizens. An event-study analysis was conducted to evaluate whether suicide rates during the COVID-19 pandemic increased compared to pre-pandemic estimates; foreign residents and Japanese citizens were compared using difference-in-difference-in-differences estimates. RESULTS: Between 2016 and 2021, 1,431 foreign residents and 121,610 Japanese citizens died from suicide in Japan. Although the suicide rate for foreign residents was lower than that for Japanese citizens, Korean residents, who comprise approximately half of the foreign decedents, had largely higher suicide rates than Japanese citizens. The event-study analysis indicated that suicide rates increased among foreign residents for both men and women, and continued for men by the end of 2021. In Japanese citizens, after a decline in suicide rates in the second quarter of 2020, suicide rates increased both among men and women, and lasted for women until the fourth quarter of 2021. The difference-in-difference-in-differences analyses confirmed the initial decline in the second quarter of 2020 in suicide rate only in Japanese men and women, and the persistent increase through 2021 in foreign men. CONCLUSIONS: We found differential trends in suicide rates between foreign and Japanese men and women during the COVID-19 pandemic featuring a persistent increase in foreign men. Suicide prevention measures should be focused on these high-risk subpopulations.

Outcomes of advanced care management in home-based long-term care: A retrospective population-based observational study
Sakiko Itoh; Takahiro Mori; Xueying Jin; Tomoko Ito; Jun Komiyama; Naoaki Kuroda; Kazuaki Uda; Rumiko Tsuchiya-Ito; Xi Vivien Wu; Kana Kodama; Hideto Takahashi; Toshihiro Takeda; Nanako Tamiya
International Journal of Nursing Studies, Jul. 2024

ポジティブ心理学に基づく幸福感を高めるための介護従事者研修による幸福度の変化
Jun. 2024

An Alternative Approach to Determining Metabolic Syndrome Component Cutoffs in Children and Adolescents Using Segmental Regression Analysis.
Ayumi Miyazaki; Masao Yoshinaga; Hiromitsu Ogata; Yoshiya Ito; Machiko Aoki; Toshihide Kubo; Masaki Shinomiya; Hitoshi Horigome; Masakuni Tokuda; Lisheng Lin; Hideto Takahashi; Masami Nagashima
Circulation reports, 10 Apr. 2024
Background: The prevalence of metabolic syndrome is increasing in children and adolescents. Although some diagnostic criteria for metabolic syndrome exist, further research is needed to determine appropriate age-, sex-, and race-specific cutoffs for each component. Methods and Results: Health examinations were conducted in 1,679 children aged 6-15 years in 9 regions of Japan. Participants were divided into 3 age groups for each sex: 6-8, 9-11, and 12-15 years. For metabolic syndrome components in each group, inverse cumulative percentile graphs were drawn and approximated by 3 regression lines using segmented regression analysis. The intersection of each regression line was defined as the breakpoint, and the measured value corresponding to the breakpoint percentile as the breakpoint value. Breakpoint values for waist circumference were age dependent at approximately 60, 70, and 80 cm for ages 6-8, 9-11, and 12-15 years, respectively. Breakpoint values for blood pressure were age- and/or sex dependent, while those for triglycerides, high-density lipoprotein cholesterol, and fasting blood glucose were neither age nor sex dependent. Based on these results, we proposed new cutoffs for diagnosing metabolic syndrome in Japanese children and adolescents. Conclusions: Breakpoint values obtained by segmented regression analysis on inverse cumulative percentile graphs can be useful for determining metabolic syndrome component cutoffs in children and adolescents.

A nationwide phase II study of delayed local treatment for children with high‐risk neuroblastoma: The Japan Children's Cancer Group Neuroblastoma Committee Trial JN‐H‐11
Akihiro Yoneda; Hiroyuki Shichino; Tomoro Hishiki; Kimikazu Matsumoto; Miki Ohira; Takehiko Kamijo; Tatsuo Kuroda; Toshinori Soejima; Atsuko Nakazawa; Tetsuya Takimoto; Isao Yokota; Satoshi Teramukai; Hideto Takahashi; Takashi Fukushima; Junichi Hara; Michio Kaneko; Hitoshi Ikeda; Tatsuro Tajiri; Hideo Mugishima; Akira Nakagawara
Pediatric Blood & Cancer, 05 Apr. 2024
Abstract

Purpose

Survival rates of patients with high‐risk neuroblastoma are unacceptable. A time‐intensified treatment strategy with delayed local treatment to control systemic diseases has been developed in Japan. We conducted a nationwide, prospective, single‐arm clinical trial with delayed local treatment. This study evaluated the safety and efficacy of delayed surgery to increase treatment intensity.

Patients and methods

Seventy‐five patients with high‐risk neuroblastoma were enrolled in this study between May 2011 and September 2015. Delayed local treatment consisted of five courses of induction chemotherapy (cisplatin, pirarubicin, vincristine, and cyclophosphamide) and myeloablative high‐dose chemotherapy (melphalan, etoposide, and carboplatin), followed by local tumor extirpation with surgery and irradiation. The primary endpoint was progression‐free survival (PFS). The secondary endpoints were overall survival (OS), response rate, adverse events, and surgical complications.

Results

Seventy‐five patients were enrolled, and 64 were evaluable (stage 3, n = 8; stage 4, n = 56). The estimated 3‐year PFS and OS rates (95% confidence interval [CI]) were 44.4% [31.8%–56.3%] and 80.7% [68.5%–88.5%], resspectively. The response rate of INRC after completion of the treatment protocol was 66% (42/64; 95% CI: 53%–77%; 23 CR [complete response], 10 VGPR [very good partial response], and nine PR [partial response]). None of the patients died during the protocol treatment or within 30 days of completion. Grade 4 adverse effects, excluding hematological adverse effects, occurred in 48% of patients [31/64; 95% CI: 36%–61%]. Major Surgical complications were observed in 25% of patients [13/51; 95% CI: 14%–40%].

Conclusion

This study indicates that delayed local treatment is feasible and shows promising efficacy, suggesting that this treatment should be considered further in a comparative study of high‐risk neuroblastoma.

Effects of Overweight on Risk of Thyroid Nodules in Children and Adolescents: The Fukushima Health Management Survey
Tetsuya Ohira; Masanori Nagao; Fumikazu Hayashi; Hiroki Shimura; Satoru Suzuki; Seiji Yasumura; Hideto Takahashi; Satoshi Suzuki; Manabu Iwadate; Mitsuaki Hosoya; Akira Sakai; Tetsuo Ishikawa; Fumihiko Furuya; Shinichi Suzuki; Susumu Yokoya; Hitoshi Ohto; Kenji Kamiya
The Journal of Clinical Endocrinology & Metabolism, 13 Mar. 2024

Characteristics of cancer patients dying at home during the COVID-19 pandemic: A study based on vital statistics from 2015 to 2022 in Japan
Yu Sun; Rie Masuda; Yuta Taniguchi; Masao Iwagami; Nobuo Sakata; Satoru Yoshie; Jun Komiyama; Kazumasa Yamagishi; Tomomi Kihara; Taeko Watanabe; Hideto Takahashi; Hiroyasu Iso; Nanako Tamiya
Journal of General and Family Medicine, 2024

Current Issues of Laws Concerning HIV/AIDS Control in the Workplace
Masashi Masuda; Yuzuru Ikushima; Tomohiro Ishimaru; Mayumi Imahashi; Hideto Takahashi; Yoshiyuki Yokomaku
SANGYO EISEIGAKU ZASSHI, 20 Nov. 2023

Recent dental visits and family caregiving among individuals with dental symptoms: A nationwide cross-sectional study in Japan.
Miho Ishimaru; Takashi Zaitsu; Shiho Kino; Yuko Inoue; Kento Taira; Hideto Takahashi; Nanako Tamiya
Community dentistry and oral epidemiology, 02 Nov. 2023
OBJECTIVES: With the increasing number of family caregivers due to the ageing population, physical and mental health problems among caregivers are of concern. However, few studies have evaluated their oral health. This study aimed to evaluate the association between being a family caregiver and recent dental visits for dental symptoms in Japan, with consideration of gender. METHODS: A cross-sectional study was conducted using the 2016 Comprehensive Survey of Living Conditions (CSLC) in Japan. Participants with dental symptoms were included in this study. The primary outcome was recent dental visits. The exposure variable of interest was being a primary caregiver for a family member requiring long-term care. A logistic regression analysis was conducted adjusting for contributing factors such as age, gender, marital status, working hours per week, education, household expenditure per month, self-rated health and the interaction between gender and caregiving. A stratified analysis by gender was also performed. RESULTS: Of the 5100 eligible participants, 233 (4.6%) were family caregivers. Of all participants, 2746 (53.8%) reported dental visits. The adjusted odds ratio (aOR) of family caregivers having recent dental visits was 0.83 (95% confidence interval [CI], 0.64-1.09). In a gender stratified analysis, family caregivers were less likely to visit dental clinics than were non-family caregivers in the male subsample (aOR: 0.56, 95% CI: 0.34-0.92) but not in the female subsample (aOR: 0.99, 95% CI: 0.72-1.38). CONCLUSIONS: The findings indicate that family caregivers, especially male caregivers, had fewer dental visits than non-family caregivers. These findings suggest the need to improve the accessibility of dental clinics to family caregivers with dental symptoms.

Dental Utilization Stratified by the Purpose of Visit: A Population-Based Study in Japan.
Miho Ishimaru; Takashi Zaitsu; Shiho Kino; Kento Taira; Yuko Inoue; Hideto Takahashi; Nanako Tamiya
International dental journal, 04 Jul. 2023
BACKGROUND: This study aimed to provide a stratified description of dental visit utilisation by Japanese residents based on patient age, sex, prefecture, and the purpose of the visits. METHODS: This cross-sectional study used the National Database of Health Insurance Claims of Japan to identify participants visiting dental clinics in Japan (April 2018-March 2019). Dental care utilisation by populations stratified by age, sex, and prefecture was assessed. We estimated the slope index of inequality (SII) and relative index of inequality (RII) to evaluate regional differences based on regional income and education. RESULTS: Amongst the Japanese population, 18.6% utilised preventive dental care visits; 59,709,084 participants visited dental clinics, with children aged 5 to 9 years having the highest proportion. SII and RII were higher for preventive dental visits than those for treatments in all settings. The largest regional differences for preventive care were observed in SII of children aged 5 to 9 years and in RII of men in their 30s and women aged 80 years and older. CONCLUSIONS: This nationwide population-based study revealed that the proportion of people utilising preventive dental care in Japan was low, with regional differences. Preventive care needs to be more easily accessible and available to improve the oral health of residents. The above findings may provide an important basis for improving policies related to dental care for residents.

Delayed Diagnosis and Prognostic Impact of Breast Cancer During the COVID-19 Pandemic
Kayo Adachi; Fuyo Kimura; Hideto Takahashi; Hiroshi Kaise; Kimito Yamada; Ei Ueno; Takahiko Kawate; Kana Miyahara; Ai Ueda; Saeko Sato; Mariko Asaoka; Miki Okazaki; Natsuki Uenaka; Kyoko Orimoto; Rongrong Wu; Yoichi Koyama; Takashi Ishikawa
Clinical Breast Cancer, Apr. 2023

Symptom severity trajectories and distresses in patients undergoing video-assisted thoracoscopic lung resection from surgery to the first post-discharge clinic visit
Tomohito Saito; Anna Hamakawa; Hideto Takahashi; Yukari Muto; Miku Mouri; Makie Nakashima; Natsumi Maru; Takahiro Utsumi; Hiroshi Matsui; Yohei Taniguchi; Haruaki Hino; Emi Hayashi; Tomohiro Murakawa
PLOS ONE, 22 Feb. 2023
This study aimed to characterize patients’ symptom severity trajectories and distresses from video-assisted thoracoscopic lung resection to the first post-discharge clinic visit. Seventy-five patients undergoing thoracoscopic lung resection for diagnosed or suspected pulmonary malignancy prospectively recorded daily symptom severity on a 0–10 numeric scale using the MD Anderson Symptom Inventory until the first post-discharge clinic visit. The causes of postoperative distresses were surveyed, and symptom severity trajectories were analyzed using joinpoint regression. A rebound was defined as a statistically significant positive slope after a statistically significant negative slope. Symptom recovery was defined as symptom severity of ≤3 in two contiguous measurements. The accuracy of pain severity on days 1–5 for predicting pain recovery was determined using area under the receiver operating characteristic curves. We applied Cox proportional hazards models for multivariate analyses of the potential predictors of early pain recovery. The median age was 70 years, and females accounted for 48%. The median interval from surgery to the first post-discharge clinic visit was 20 days. Trajectories of several core symptoms including pain showed a rebound from day 3 or 4. Specifically, pain severity in patients with unrecovered pain had been higher than those with recovered pain since day 4. Pain severity on day 4 showed the highest area under the curve of 0.723 for predicting pain recovery (P = 0.001). Multivariate analysis identified pain severity of ≤1 on day 4 as an independent predictor of early pain recovery (hazard ratio, 2.86; P = 0.0027). Duration of symptom was the leading cause of postoperative distress. Several core symptoms after thoracoscopic lung resection showed a rebound in the trajectory. Specifically, a rebound in pain trajectory may be associated with unrecovered pain; pain severity on day 4 may predict early pain recovery. Further clarification of symptom severity trajectories is essential for patient-centered care.

Workplace factors associated with willingness to undergo human immunodeficiency virus testing during workplace health checkups
Kazuyoshi Mizuki; Tomohiro Ishimaru; Mayumi Imahashi; Yuzuru Ikushima; Hideto Takahashi; Masashi Masuda; Yoshiyuki Yokomaku
Environmental Health and Preventive Medicine, 2023

Revisiting the Geographical Distribution of Thyroid Cancer Incidence in Fukushima Prefecture: Analysis of Data From the Second- and Third-round Thyroid Ultrasound Examination
Tomoki Nakaya; Kunihiko Takahashi; Hideto Takahashi; Seiji Yasumura; Tetsuya Ohira; Hiroki Shimura; Satoru Suzuki; Satoshi Suzuki; Manabu Iwadate; Susumu Yokoya; Hitoshi Ohto; Kenji Kamiya
Journal of Epidemiology, 05 Dec. 2022

Developmental trajectories at a high risk for childhood overweight/obesity.
Masao Yoshinaga; Hideto Takahashi; Yoshiya Ito; Machiko Aoki; Ayumi Miyazaki; Toshihide Kubo; Masaki Shinomiya; Hitoshi Horigome; Masakuni Tokuda; Lisheng Lin; Hiromitsu Ogata; Masami Nagashima
Pediatrics international : official journal of the Japan Pediatric Society, 23 Nov. 2022
BACKGROUND: The associations between developmental patterns (trajectories) in children and maternal factors have been widely investigated, but paternal effects on these trajectories are unclear. This study aimed to determine children's and parental factors involved in developmental trajectories at a high risk for having adverse cardiovascular (CV) profiles in children. METHODS: We analysed longitudinal anthropometric data from birth to present and CV profiles of 1832 healthy volunteers (51% girls) aged 3-15 years who participated in a nationwide study between July 2012 and January 2014. Six-trajectory latent class growth models were developed using body mass index Z-scores. Predictors for being in developmental trajectories at a high risk for adverse CV profiles were determined by multivariate regression analysis. RESULTS: The mean number of anthropometric data points was 12±3 for both boys and girls. Among the six trajectories, the infantile onset and continual increase groups had significantly worse levels of many CV profiles than those in the remaining groups. Paternal overweight/obesity was an independent predictor for boys being in the infantile onset group and for girls being in the continual increase group. Additionally, maternal pre-pregnancy overweight/obesity in boys and maternal excessive gestational weight gain in girls were independent predictors for being in the infantile onset group. Having no other sibling in boys and an older maternal age were independent predictors for being in the continual increase group. CONCLUSIONS: Interventions to prevent childhood obesity should include strategies that focus on fathers and mothers and those that focus on children with some familial backgrounds.

Mortality differences in disabled older adults by place of care in Japan: nationwide 10-year results
Tomoko Ito; Mikiya Sato; Hideto Takahashi; Chihiro Omori; Yuta Taniguchi; Xueying Jin; Taeko Watanabe; Haruko Noguchi; Nanako Tamiya
Journal of Public Health Policy, 28 Oct. 2022

[Validation of using disqualification from long-term care insurance registry as a proxy of death].
Mikiya Sato; Tomoko Ito; Yuta Taniguchi; Chihiro Omori; Xueying Jin; Taeko Watanabe; Hideto Takahashi; Haruko Noguchi; Nanako Tamiya
[Nihon koshu eisei zasshi] Japanese journal of public health, 04 Aug. 2022
Objectives The national database for long-term care insurance (LTCI) of Japan (Kaigo DB) enables researchers to access comprehensive data from its LTCI registry, eligibility assessment records, claims for service usage, and information about service providers. However, studies regarding the death or mortality of beneficiaries cannot be conducted because Kaigo DB does not contain death records, and researchers are not allowed to link Kaigo DB to other databases, such as national death records. Therefore, we aimed to assess the validity of using an insurer's disqualification from an LTCI beneficiary as a proxy of death.Methods We used 510,751,798 monthly beneficiary records between April 2007 and March 2017 from the LTCI registry, while excluding data for ineligible persons for LTCI benefit or those younger than 65 years. We identified insurer cases disqualified from LTCI beneficiaries and linked them to national death records using deterministic linkage methods by dates of birth and death, sex, and residence. We considered the cases as positive if they were disqualified and their record was linked to a death. We used sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) as validity indices.Results We identified 5,986,991 (1.17%) disqualified and 5,295,961 death cases. Sensitivity, specificity, PPV, and NPV of disqualification for death were 100%, 99.86%, 88.46%, and 100%, respectively. After stratification, PPV of disqualification was between 85% and 88% before 2012, 91% after 2012, 91.9% in men, and 85.9% in women. PPV increased with age (65-69 years: 80.6%, 70-74 years: 86.7%, 75-79 years: 86.4%, 80-84 years: 86.7%, 85-89 years: 88.0%, 90-94 years: 90.6%, and 95+ years: 93.4%) and level of care needed (support level: 72.2%, care level (CL) 1: 79.7%, CL2: 85.9%, CL3: 89.3%, CL4: 92.3%, and CL5: 94.0%).Conclusions Disqualification from the LTCI registry is an inappropriate measure to estimate mortality accurately because it has a 10% false-positive rate. However, it appears sufficiently valid to use disqualification as a proxy outcome of death, although the main effect or confounding of a possible predictor of death could be slightly underestimated.

介護保険受給者台帳の資格喪失記録を死亡代理変数として使用することの妥当性の検討
Aug. 2022

Association of marital status and access to dental care among the Japanese population: a cross-sectional study.
Yuko Inoue; Takashi Zaitsu; Akiko Oshiro; Miho Ishimaru; Kento Taira; Hideto Takahashi; Jun Aida; Nanako Tamiya
BMC oral health, 07 Jul. 2022
BACKGROUND: Health disparities according to marital status have been reported worldwide. Although spouses provide an important social network that influences heath behaviors, limited studies have examined the association between marital status and access to dental care. Therefore, this study aimed to analyze the association between marital status and access to dental care. METHODS: A secondary analysis of the 2013 Comprehensive Survey of Living Conditions in Japan which is a national survey, was performed in this study. Out of 367,766 respondents, 4111 respondents, aged over 40 years who selected oral symptoms as their most concerning subjective symptom were recruited as participants. The independent variable of interest was marital status-married or non-married (single, divorced, widowed); and the dependent variable was access to dental care. We performed Poisson regression analyses stratified by sex with adjustment for age, educational status, employment, equivalent household expenditure, and smoking habits. RESULTS: Among respondents who reported oral symptoms, 3024 were married, and 1087 were non-married. Further, 29.4% and 40.4% of married and non-married men, respectively, did not receive dental treatment for their symptoms. Meanwhile, 27.5% and 25.0% of married and non-married women, respectively, did not receive dental treatment for their symptoms. The prevalence ratio for not receiving dental treatment was significantly higher among non-married men (prevalence ratio: 1.33; 95% confidence interval: 1.14-1.56) than among married men. However, no significant association was observed among women. CONCLUSIONS: Non-married men were highly unlikely to receive dental treatment than married men, while no significant association was observed among women. The results implicate the importance of implementing a public dental health policy for protecting the dental health of non-married individuals.

Characteristics of Hospitals Employing Dentists, and Utilization of Dental Care Services for Hospitalized Patients in Japan: A Nationwide Cross-Sectional Study.
Miho Ishimaru; Kento Taira; Takashi Zaitsu; Yuko Inoue; Shiho Kino; Hideto Takahashi; Nanako Tamiya
International journal of environmental research and public health, 26 May 2022
Dental care for hospitalized patients can improve nutritional status and feeding function while reducing complications. However, such care in Japan is not uniformly provided. This investigation examined the presence and characteristics of hospitals where dentists work and the collaboration between medical and dental teams. This cross-sectional study involves 7205 hospitals using the administrative reports on the Hospital Bed Function of 2018. Indicators described were the proportion of hospitals employing dentists, those providing perioperative oral care, and those with a nutrition support team (NST) that included dentists. A two-level logistic regression model was performed using hospital-based and secondary medical area-based factors to identify factors associated with hospitals employing dentists and dental care services. Some hospitals had poor medical and dental collaboration, even those with dentists, and no-dentist hospitals had rare medical and dental collaboration. Factors positively associated with hospitals that employed dentists were diagnosis-procedure-combination-hospital types, the Japanese government-established hospitals compared with hospitals established by public organizations, among others. In conclusion, the present study found poor medical and dental collaboration was observed in some hospitals and that hospital type, region, and hospital founders were associated with the performance of collaborative medical and dental care.

小児がん外科治療の新しい試み 中間リスク神経芽腫における外科治療の検討
Apr. 2022

小児がん外科治療の新しい試み 中間リスク神経芽腫における外科治療の検討
Apr. 2022

Electrocardiographic Diagnosis of Hypertrophic Cardiomyopathy in the Pre- and Post-Diagnostic Phases in Children and Adolescents
Masao Yoshinaga; Hitoshi Horigome; Mamoru Ayusawa; Kazushi Yasuda; Shigetoyo Kogaki; Shozaburo Doi; Sigeru Tateno; Kunio Ohta; Tatsunori Hokosaki; Eiki Nishihara; Mari Iwamoto; Naokata Sumitomo; Hiroya Ushinohama; Naomi Izumida; Nobuo Tauchi; Yoshiaki Kato; Taichi Kato; Toshiyuki Chisaka; Takashi Higaki; Tatsuya Yoneyama; Katsumi Abe; Yoshihiro Nozaki; Akiko Komori; Satoru Kawai; Yumiko Ninomiya; Yuji Tanaka; Norihito Nuruki; Masahiro Sonoda; Kentaro Ueno; Daisuke Hazeki; Yuichi Nomura; Seiichi Sato; Keiichi Hirono; Susumu Hosokawa; Fumie Takechi; Yuichi Ishikawa; Tadayoshi Hata; Fukiko Ichida; Seiko Ohno; Naomasa Makita; Minoru Horie; Shouji Matsushima; Hiroyuki Tsutsui; Hiromitsu Ogata; Hideto Takahashi; Masami Nagashima
Circulation Journal, 24 Dec. 2021

Association between exposure to secondhand smoking at home and tooth loss in Japan: A cross-sectional analysis of data from the 2016 National Health and Nutrition Survey
Yuko Inoue; Takashi Zaitsu; Oshiro Akiko; Miho Ishimaru; Kento Taira; Hideto Takahashi; Jun Aida; Nanako Tamiya
Tobacco Induced Diseases, 10 Dec. 2021

[The relationship between information sources, media, and "anxiety about the effects of radiation on future generations" in Hamadori and Fukushima Prefecture's evacuation areas after the nuclear accident].
Chihiro Nakayama; Hajime Iwasa; Nobuaki Moriyama; Hideto Takahashi; Seiji Yasumura
[Nihon koshu eisei zasshi] Japanese journal of public health, 04 Dec. 2021
Objectives Nine years after the accident at the TEPCO Fukushima Daiichi Nuclear Power Plant in March 2011, anxiety about the effects of radiation on future generations persists. We considered the possibility that information from mass media sources and the Internet might influence this anxiety. Thus, this study examined the relationship between information sources and anxiety; based on the results, we consider the necessary measures to reduce this anxiety.Methods We conducted a mail-based survey by distributing an anonymous self-administered questionnaire to 2,000 Fukushima Prefecture residents aged 20 to 79. We randomly selected 500 residents from Aizu, Nakadori, Hamadori, and the evacuation areas, and compared the data obtained from Hamadori and the evacuation areas. The objective variable was anxiety about the effects (of radiation) on future generations, while the explanatory variables were trusted sources and media the respondents used to get information on radiation. Other variables assessed included health status and knowledge of radiation. We conducted univariate analysis of combined data to assess the relationship between anxiety and the questionnaire items. This was followed by multiple regression analysis with anxiety as the objective variable and those showing significant differences in the univariate analysis as the explanatory ones. We then conducted multiple regression analysis, that included the interaction means between explanatory variables and evacuation areas.Results Of the 500, 201 respondents were from Hamadori (40.2%) and 192 from the evacuation areas (38.4%). Multiple regression analysis revealed that anxiety was significantly lower among those who trusted government ministries and those who were healthy. Anxiety was also significantly lower among those who correctly answered the question on the genetic influence of radiation, while it was significantly higher among those who correctly answered the question on the dose-response model of radiation-induced cancer. In Hamadori, anxiety was significantly higher among those who watched private national television. In the evacuation areas, the result was the same as that of the combined data.Conclusion Different information sources and media were significantly associated with anxiety about the effects of radiation on future generations. Therefore, media sensationalism should be reduced to prevent anxiety among citizens. Our findings highlight the importance of selecting information sources and media that disseminate accurate information, as well as the need to improve media literacy among citizens. Furthermore, a dose-response model of radiation-induced cancer must be communicated in a way that is not misleading. Receiving accurate information on the genetic effects of radiation can reduce anxiety among citizens.

Regional Inequality in Dental Care Utilization in Japan: An Ecological Study Using the National Database of Health Insurance Claims
Kento Taira; Takahiro Mori; Miho Ishimaru; Masao Iwagami; Nobuo Sakata; Taeko Watanabe; Hideto Takahashi; Nanako Tamiya
The Lancet Regional Health - Western Pacific, Jun. 2021

Prevention services via public long-term care insurance can be effective among a specific group of older adults in Japan.
Tomoko Ito; Takahiro Mori; Hideto Takahashi; Natsumi Shimafuji; Katsuya Iijima; Satoru Yoshie; Nanako Tamiya
BMC health services research, 30 May 2021, [Reviewed]
BACKGROUND: To evaluate the effects of prevention services provided by long-term care insurance (LTCI) for older adults who require support from LTCI in Kashiwa City, Japan. METHODS: We conducted an analysis using the following population-based longitudinal data in Kashiwa City between April 2012 and March 2015: Data of National Health Insurance and LTCI claims, the survey for certification of LTCI, the register, and premium tier classification. All data was linked using the pre-assigned anonymous identifying numbers. We analyzed the Cox regression model using the time for the deteriorations of levels of certified care need in LTCI as an outcome and the use of preventive care services as the primary exposure among participants aged 75 years or older, who had either support levels 1 or 2 at the beginning of this analysis. The study was further stratified by both age and initial support level. RESULTS: The final analysis included 1289 participants. The primary result showed, among all participants, that preventive service was not effective (hazard ratio 0.96, 95% confidence interval 0.78-1.19). In our sub-analysis, the preventive service was effective in avoiding deteriorations only among those aged 85 and older with support level 1 (HR 0.65, 95% CI 0.43-0.97) out of four groups. CONCLUSIONS: The preventive services of LTCI in Kashiwa City showed a significant effect on the deterioration among subjects aged 85 or older, whose disability level were low (support level 1). Our results suggest that the prevention services provided by LTCI may not be effective for all older individuals; to provide these services efficiently, local governments, as insurers of LTCI, will need to identify the specified groups that may benefit from the preventive services. Additionally, it is necessary to re-examine what preventive interventions may be effective, or redesign the health system if necessary, for those who were not affected by the intervention.

Cost-Effectiveness of Behavior Modification Intervention for Patients With Chronic Kidney Disease in the FROM-J Study.
Reiko Okubo; Masahide Kondo; Shu-Ling Hoshi; Masafumi Okada; Mariko Doi; Hideto Takahashi; Hirayasu Kai; Chie Saito; Kunitoshi Iseki; Chiho Iseki; Tsuyoshi Watanabe; Ichiei Narita; Seiichi Matsuo; Hirofumi Makino; Akira Hishida; Kunihiro Yamagata
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 17 Mar. 2021, [Reviewed]
OBJECTIVES: Chronic kidney disease (CKD) is a significant public health problem. An advanced, or innovative, CKD care system of clinical practice collaboration among general physicians (GPs), nephrologists, and other healthcare workers achieved behavior modification in patients with Stage 3 CKD in the Frontier of Renal Outcome Modifications in Japan (FROM-J) study. This behavior modification intervention consisted of educational sessions on nutrition and lifestyle, as well as encouragement of patients' regular visits. The intervention contributed to slowing CKD progression. This study aimed to evaluate the cost-effectiveness of the widespread diffusion of the behavior modification intervention proven effective by the FROM-J study. METHODS: A cost-effectiveness analysis was carried out to compare the behavior modification intervention with the current practice recommended by the latest CKD clinical guidelines for GPs. A Markov model with a societal perspective under Japan's health system was constructed. We assumed that the behavior modification intervention proven effective by the FROM-J study would be initiated by GPs for targeted patient cohorts-patients aged 40-74 years with Stage 3 CKD-as a part of the innovative CKD care system. RESULTS: The incremental cost-effectiveness ratio for the behavior modification intervention compared with current guideline-based practice was calculated as 145,593 Japanese yen (\; $1,324 United States dollars [$]) per quality-adjusted life year (QALY). CONCLUSIONS: Using the suggested value of social willingness to pay for a one-QALY gain in Japan of \5 million (US$45,455) as the threshold to judge cost-effectiveness, the behavior modification intervention is cost-effective. Our results suggest that diffusing the behavior modification intervention proven effective by the FROM-J study could be justifiable as an efficient use of finite healthcare resources. GPs could be encouraged to initiate this intervention by revising the National Health Insurance fee schedule and strengthening clinical guidelines regarding behavior modification interventions.

Impact of a Japanese Incentivization Program to Increase End-of-Life Care Outside of Hospitals.
Mikiya Sato; Nanako Tamiya; Xueying Jin; Taeko Watanabe; Hideto Takahashi; Haruko Noguchi
Journal of the American Medical Directors Association, 04 Nov. 2020, [Reviewed]
OBJECTIVES: To analyze the association of an incentivization program to promote death outside of hospitals with changes in place of death. DESIGN: A longitudinal observational study using national databases. SETTING AND PARTICIPANTS: Participants comprised Japanese decedents (≥65 years) who had used long-term care insurance services and died between April 2007 and March 2014. METHODS: Using a database of Japanese long-term care insurance service claims, subjects were divided into community-dwelling and residential aged care (RAC) facility groups. Based on national death records, change in place of death after the Japanese government initiated incentivization program was observed using logistic regression. RESULTS: Hospital deaths decreased by 8.7% over time, mainly due to an increase in RAC facility deaths. The incentivization program was more associated with decreased in-hospital deaths for older adults in RAC facilities than community-dwelling older adults. CONCLUSIONS AND IMPLICATIONS: In Japan, the proportion of in-hospital deaths of frail older adults decreased since the health services system introduced the incentivization program for end-of-life care outside of hospitals. The shift of place of death from hospitals to different locations was more prominent among residents of RAC facilities, where informal care from laymen was required less, than among community residents.

Influence of post-disaster evacuation on incidence of hyperuricemia in residents of Fukushima Prefecture: the Fukushima Health Management Survey
Shigeatsu Hashimoto; Masato Nagai; Tetsuya Ohira; Shingo Fukuma; Mitsuaki Hosoya; Seiji Yasumura; Hiroaki Satoh; Hitoshi Suzuki; Akira Sakai; Akira Ohtsuru; Yukihiko Kawasaki; Atsushi Takahashi; Kanako Okazaki; Gen Kobashi; Kenji Kamiya; Shunichi Yamashita; Shun ichi Fukuhara; Hitoshi Ohto; Masafumi Abe; Kenii Kamiya; Shinichi Suzuki; Hirooki Yabe; Masaharu Maeda; Shirou Matsui; Keiya Fujimori; Tetsuo Ishikawa; Tsuyoshi Watanabe; Kotaro Ozasa; Shigeatsu Hashimoto; Satoru Suzuki; Toshihiko Fukushima; Sanae Midorikawa; Hiromi Shimura; Hirofumi Mashiko; Aya Goto; Kenneth Eric Nollet; Shinichi Niwa; Hideto Takahashi; Yoshisada Shibata
Clinical and Experimental Nephrology, 01 Nov. 2020

Transfusion-Related Alloimmunization to Red Blood Cell Antigens in Japanese Pediatric Recipients.
Yoshiko Tamai; Hitoshi Ohto; Hideto Takahashi; Junichi Kitazawa
Transfusion medicine reviews, 10 Sep. 2020, [Reviewed]
Red blood cell (RBC) transfusion to neonates is thought to rarely provoke an immune response. Neonatal testing guidelines suggest that antibody screening is not necessary when the mother has no antibodies. Alternatively, maternal blood samples can be used for antibody screening and cross-matching. However, the guidelines are based on small-scale studies of white-dominant populations. Furthermore, transfusion-related alloimmunization is less well established among children and adolescents as a whole among Japanese and East Asians. To elucidate the incidence of transfusion-related alloimmunization among neonates, children, and adolescents, and whether current guidelines are applicable to Japanese populations, a nationwide retrospective multicenter cohort survey was conducted in 50 tertiary-care hospitals in Japan. Between 2001 and 2015 inclusive, recipients of at least 1 allogeneic RBC transfusion were categorized into groups A-F according to their age at the time of transfusion: (A) neonates <1 month; (B) infants 1 to <12 months; (C) children 1 to <5 years; (D) prepubescents 5 to <10 years; (E) young pubescents 10 to <15 years; and (F) adolescents/young adults 15 to <20 years. Excluding maternally derived antibodies and naturally occurring, cold-reactive, and/or nonspecific antibodies, 69 (0.61%) of 11350 RBC recipients <20 years old formed at least 1 clinically significant alloantibody. The alloimmunization rate differed significantly (P < .0001) by age: none (0%) of 3407 in group A; 11 (0.46%) of 2410 in group B; 18 (0.76%) of 2361 in group C; 9 (0.80%) of 1119 in group D; 12 (1.15%) of 1043 in group E; and 19 (1.88%) of 1010 in group F. Clearly different incidences of alloimmunization emerged in group A compared to B, C, D, E, or F, as confirmed by logistic regression analysis adjusted by numbers of donor exposure. Alloimmunization did not occur from RBC transfusions within the first month of life and rarely occurred (0.46%-0.80%) after transfusion within the first decade of life. Alloimmunization occurred in 1.15%-1.88% of young pubescents and adolescents/young adults. These findings support the use of guidelines developed in Europe and the United States for East Asian pediatric recipients.

The association between activities of daily living and long hours of care provided by informal caregivers using a nationally representative survey in Japan.
Hiroaki Ueshima; Arito Yozu; Hideto Takahashi; Haruko Noguchi; Nanako Tamiya
SSM - population health, Aug. 2020
•We determined the relationship between long hours of care and the assistance in each activity of daily living (ADL) element.•The assistance in wiping of the body, dressing and toileting were significantly associated with longer hours of care .•To support caregivers effectively, it is important to consider the kinds of ADL elements of the care recipients.

Promoting physical activity through walking to treat childhood obesity, mainly for mild to moderate obesity.
Masao Yoshinaga; Ayumi Miyazaki; Machiko Aoki; Hiromitsu Ogata; Yoshiya Ito; Takashi Hamajima; Masakuni Tokuda; Lisheng Lin; Hitoshi Horigome; Hideto Takahashi; Masami Nagashima
Pediatrics international : official journal of the Japan Pediatric Society, Aug. 2020
BACKGROUND: There are no randomized controlled trials examining the effect of walking on childhood obesity. METHODS: A randomized controlled trial was conducted between August 2014 and April 2015 in Japan. Elementary school children aged 6 to 12 years with a percentage overweight (%OW) of ≥20% were recruited. One hundred and ninety children wanted to participate in the program, and all were accepted. After viewing a video that promoted physical activity through walking, participants were randomly assigned to three groups: walking (≥10 000 steps on school holidays), limiting screen time (<90 min on weekdays and <150 min on school holidays), and a control group (no intervention). The primary outcome was a decrease in %OW after 3 months' intervention. Per protocol analysis was performed using 156 participants who fulfilled the inclusion criteria of a %OW ≥20%. RESULTS: The mean %OW was 35 ± 7% before intervention. The mean reduction in %OW after intervention in the walking (n = 59), limiting ST (n = 46), and control (n = 51) groups were -4.06 ± 4.84, -1.97 ± 4.62, and -1.81 ± 3.64 percentage points, respectively. Reduction in %OW was significantly larger in the walking group than in the control group: adjusted mean difference, -2.18 percentage points (95% confidence interval, -3.85 to -0.52), P = 0.002. The intervention in children also had favorable effects on the lifestyles of their parents. The intention-to-treat analysis of all 190 participants showed comparable results. CONCLUSION: Promoting physical activity through walking on school holidays may be an additional strategy for treating elementary school children with obesity.

Concordance of hypertension, diabetes and dyslipidaemia in married couples: cross-sectional study using nationwide survey data in Japan.
Taeko Watanabe; Takehiro Sugiyama; Hideto Takahashi; Haruko Noguchi; Nanako Tamiya
BMJ open, 28 Jul. 2020
OBJECTIVE: Because married couples have many environmental influences in common, spouses may develop similar diseases. This study aimed to determine the concordance of hypertension, diabetes and dyslipidaemia, which are major risk factors for cardiovascular disease, among married couples in Japan. RESEARCH DESIGN AND METHODS: We conducted a cross-sectional study of married couples who were both aged ≥40 years using the 2016 Comprehensive Survey of Living Conditions, which is a Japanese national survey. We first determined the proportions of wives and husbands who were receiving therapy for each of the diseases of interest. We then conducted logistic regression analyses using the wives undergoing therapy for each disease as outcomes and the husbands undergoing therapy for the same disease as the principal exposure, adjusting for covariates. RESULTS: The subjects of the analyses were 86 941 married couples. The wives of male patients were significantly more likely to be receiving therapy for the same disease. Logistic regression revealed that when husbands were undergoing therapy for these diseases their wives had ORs (95% CIs) of 1.79 (1.72-1.86) for hypertension, 1.45 (1.34-1.58) for diabetes, 2.58 (2.41-2.75) for dyslipidaemia and 1.87 (1.80-1.93) for any of these diseases. CONCLUSIONS: If men have hypertension, diabetes or dyslipidaemia, their wives were also more susceptible to the same disease. Medical professionals and couples may need to recognise these results and consider couple-based interventions to help the prevention, early detection and treatment of these diseases.

Factors Influencing the Proportion of Non-examinees in the Fukushima Health Management Survey for Childhood and Adolescent Thyroid Cancer: Results From the Baseline Survey.
Kunihiko Takahashi; Hideto Takahashi; Tomoki Nakaya; Seiji Yasumura; Tetsuya Ohira; Hitoshi Ohto; Akira Ohtsuru; Sanae Midorikawa; Shinichi Suzuki; Hiroki Shimura; Shunichi Yamashita; Koichi Tanigawa; Kenji Kamiya
Journal of epidemiology, 07 Jul. 2020, [Reviewed]
BACKGROUND: After the Fukushima Daiichi Nuclear Power Plant accident, a preliminary ultrasound-based screening for thyroid cancer was conducted to establish a baseline for subsequent evaluations. In this survey, we assessed the relationship between the proportion of non-examinees and characteristics of the target populations. METHODS: After summarizing a regional difference of non-examinees among the population of 359,200 (primary evaluation) and 2,246 (confirmatory testing) individuals who were living in Fukushima Prefecture on March 11, 2011, we estimated odds ratios (ORs) for each characteristic, including age, sex, area of residence, and moving after the accident, based on the proportion of non-examinees for the primary examination and the confirmatory testing, using a multivariate logistic regression model. RESULTS: The dataset included 64,117 non-examinees (primary evaluation) and 194 (confirmatory testing). The logistic regression result indicated that girls were not likely to be non-examinees compared to boys, with adjusted OR of 0.80 (95% confidence interval [CI], 0.78-0.81) for the primary evaluation. Odds were lowest for children 6-10 years old (OR 0.26; 95% CI, 0.25-0.27), and higher for those 11-15 years old (OR 1.28; 95% CI, 1.25-1.32) and over 16 years old (OR 5.30; 95% CI, 5.16-5.43) when compared to children 0-5 years old. Individuals residing in the western part of the prefecture showed higher ORs. There was a higher proportion of non-examinees among those who moved after the accident compared to those who did not in the primary evaluation (OR 1.72; 95% CI, 1.64-1.79). CONCLUSIONS: In addition to demographic characteristics, a change of residence could be a potential factor that influenced the proportion of non-examinees. Our results will help proper interpretation of reports and prospective management of the survey.

Nested matched case control study for the Japan Fukushima Health Management Survey's first full-scale (second-round) thyroid examination.
Hideto Takahashi; Seiji Yasumura; Kunihiko Takahashi; Tetsuya Ohira; Akira Ohtsuru; Sanae Midorikawa; Satoru Suzuki; Hiroki Shimura; Tetsuo Ishikawa; Akira Sakai; Shinichi Suzuki; Susumu Yokoya; Koichi Tanigawa; Hitoshi Ohto; Kenji Kamiya
Medicine, 02 Jul. 2020
Since Fukushima nuclear accident in 2011, thyroid ultrasound examinations have been conducted. The first full-scale examination detected 71 thyroid-cancer cases. This study examined whether radiation exposure was associated with thyroid-cancer incidence.Subjects were participants in the baseline screening and newborns during the 2011 fiscal year. Under nested matched case-control study design, 10 controls per each case were selected by matching the age, sex, baseline screening results, and interval between examinations. With 3 dose levels of external radiation: 1.3 + mSv (upper), 0.8 to 1.3 (middle), and 0.0 to 0.8 (reference), we applied 2 logistic models adjusting for 3 participation-proportions (primary, secondary, and fine-needle aspiratory cytology), overweight, and the B-result of baseline screening (Model 1), and past medical history, family history of thyroid cancer, and frequencies of eating seafood and seaweed in addition to the parameters in Model 1 (Model 2). We examined each model in 3 ways: (a) excluding subjects with a missing radiation exposure dose; and substituting (b1) median or (b2) mean dose of the municipality with missing dose.Odds ratios (ORs) of middle-dose exposure were (a) 1.35 (0.46-3.94), (b1) 1.55 (0.61-3.96), and (b2) 1.23 (0.50-3.03) for Model 1, and (a) 1.18 (0.39-3.57), (b1) 1.31 (0.49-3.49), and (b2) 1.02 (0.40-2.59) for Model 2. For upper-dose exposure, similar results were obtained. Past medical history was significantly associated (odds ratio  = 2.04-2.08) with both (b1) and (b2) in Model 2.No significant associations were obtained between the external radiation exposure and thyroid-cancer incidence.

A significance of school screening electrocardiogram in the patients with ventricular noncompaction.
Keiichi Hirono; Nariaki Miyao; Masao Yoshinaga; Eiki Nishihara; Kazushi Yasuda; Shigeru Tateno; Mamoru Ayusawa; Naokata Sumitomo; Hitoshi Horigome; Mari Iwamoto; Hideto Takahashi; Seiichi Sato; Shigetoyo Kogaki; Seiko Ohno; Tadayoshi Hata; Daisuke Hazeki; Naomi Izumida; Masami Nagashima; Kunio Ohta; Nobuo Tauchi; Hiroya Ushinohama; Shozaburo Doi; Fukiko Ichida
Heart and vessels, Jul. 2020
Left ventricular noncompaction (LVNC) is a hereditary cardiomyopathy and is associated with high morbidity and mortality. However, the role and significance of school screening for LVNC have not been fully elucidated. In this multicenter, retrospective cohort study, a total of 105 children with LVNC were included from 2000 to 2017. At the initial presentation, 44 patients (41.9%) were diagnosed by school screening. One (1.0%) patient underwent heart transplantation and four (3.8%) patients died during the study. Electrocardiogram data showed a high prevalence of fragmented QRS (33.4%) and J wave (15.7%). Treatments were needed in eight (18.2%) patients who were detected by school screening. The multivariable proportional hazards model showed T-wave abnormality on electrocardiogram in first graders was independent risk factors for major adverse cardiac events (odds ratio 4.94, p value = 0.0007). Moreover, dilation of the left atrium on chest X-ray and low ejection fraction on echocardiogram at the initial treatment were independent risk factors for treatment (odds ratio 1.7 × 107 and 22.3, p = 0.0362 and 0.0028, respectively). This study is the first report focusing on school screening in a large pediatric cohort with LVNC. With the use of abnormalities in electrocardiogram, school screening may be a good detector of and predictor for LVNC.

Effect of reduced formal care availability on formal/informal care patterns and caregiver health: a quasi-experimental study using the Japanese long-term care insurance reform.
Atsushi Miyawaki; Yasuki Kobayashi; Haruko Noguchi; Taeko Watanabe; Hideto Takahashi; Nanako Tamiya
BMC geriatrics, 12 Jun. 2020
BACKGROUND: It is unclear how formal long-term care (LTC) availability affects formal /informal caregiving patterns and caregiver health. We tested the impact of reduced formal LTC availability on formal LTC service use, intensity of informal caregiving, and caregiver health. METHODS: Using a representative, repeated cross-sectional sample of Japanese caregivers providing care to co-resident family members from 2001 to 2016, we applied a difference-in-differences approach by observing caregivers before and after the major reform of the public Japanese LTC insurance (LTCI) in 2006. The reform reduced coverage benefits for non-institutionalized older persons with low care needs, but not for those with high care needs. We analyzed 12,764 caregivers aged ≥30 years (mean age 64.3 ± 11.8 years, 73.5% women) and measured indicators of formal LTC use, hours of informal caregiving, and caregiver self-reported health outcomes after propensity score matching to balance caregivers' background characteristics. RESULTS: We found the 2006 LTCI reform relatively reduced the use of formal LTC services and relatively increased the percentage of experiencing long hours of informal caregiving (> 3 h per day) among the caregivers for seniors with low care needs compared to those for seniors with high care needs. The effects of the LTCI reform for the caregivers for seniors with low care needs were 2.2 percentage point higher on caregivers' experiencing poor self-rated health (95% confidence interval [CI]: 0.7-3.7; p = 0.01), 2.7 percentage point higher on experiencing symptoms of a depressive state (95%CI: 0.5-4.8; p = 0.03), and 4.7 percentage point higher on experiencing symptoms of musculoskeletal diseases (95%CI, 3.6-5.7; p < 0.001), compared to those for seniors with high care needs. CONCLUSIONS: Reduced formal care availability under the Japanese LTCI reform increased hours of informal caregiving corresponding to reduced use of formal LTC and deteriorated multiple dimensions of caregiver health. Our findings may highlight the importance of enhancing the availability of formal LTC services for caregiver health.

A phase II JN-I-10 efficacy study of IDRF-based surgical decisions and stepwise treatment intensification for patients with intermediate-risk neuroblastoma: a study protocol.
Tomoko Iehara; Akihiro Yoneda; Atsushi Kikuta; Toshihiro Muraji; Kazuaki Tokiwa; Hideto Takahashi; Satoshi Teramukai; Tetsuya Takimoto; Shigeki Yagyu; Hajime Hosoi; Tatsuro Tajiri
BMC pediatrics, 12 May 2020, [Reviewed]
BACKGROUND: Few clinical trials have been reported for patients with intermediate-risk neuroblastoma because of the scarcity of the disease and the variety of clinical and biological characteristics. A multidisciplinary treatment that consists of multidrug chemotherapy and surgery is expected to lead to a good prognosis with few complications. Therefore, a clinical trial for patients with intermediate-risk tumors was designed to establish a standard treatment that reduces complications and achieves good outcomes. METHODS: We planned a prospective phase 2, single-arm study of the efficacy of image-defined risk factors (IDRF)-based surgical decision and stepwise treatment intensification for patients with intermediate-risk neuroblastomas. For the localized tumor group, IDRF evaluations will be performed after each three-course chemotherapy, and surgery will be performed when appropriate. For patients with metastatic tumors, a total of five chemotherapy courses will be performed, and primary lesions will be removed when the IDRF becomes negative. The primary endpoint is 3-year progression-free survival rate, and the secondary endpoints include 3-year progression-free survival rates and overall survival rates of the localized group and the metastasis group and the incidence of adverse events. From international results, 75% is considered an appropriate 3-year progression-free survival rate. If this trial's expected 3-year progression-free survival rate of 85% is statistically greater than 75% in the lower limit of the 95.3% confidence interval, with an accuracy 10% (85 ± 10%), both groups require more than 65 patients. DISCUSSION: This study is the first clinical trial on the efficacy of IDRF-based surgical decision and stepwise treatment intensification for patients with intermediate-risk neuroblastomas. We expect that this study will contribute to the establishment of a standard treatment for patients with intermediate-risk neuroblastoma. TRIAL REGISTRATION: UMIN000004700, jRCTs051180203; Registered on December 9, 2010.

Absorbed radiation doses in the thyroid as estimated by UNSCEAR and subsequent risk of childhood thyroid cancer following the Great East Japan Earthquake.
Tetsuya Ohira; Hiroki Shimura; Fumikazu Hayashi; Masanori Nagao; Seiji Yasumura; Hideto Takahashi; Satoru Suzuki; Takashi Matsuzuka; Satoshi Suzuki; Manabu Iwadate; Tetsuo Ishikawa; Akira Sakai; Shinichi Suzuki; Kenneth E Nollet; Susumu Yokoya; Hitoshi Ohto; Kenji Kamiya
Journal of radiation research, 23 Mar. 2020, [Reviewed]
The identification of thyroid cancers among children after the Chernobyl nuclear power plant accident propelled concerns regarding long-term radiation effects on thyroid cancer in children affected by the Fukushima Daiichi nuclear power plant accident in Fukushima, Japan. Herein we consider the potential association between absorbed dose in the thyroid and the risk of developing thyroid cancer as detected by ultrasonography on 300 473 children and adolescents aged 0-18 years in Fukushima. The absorbed dose mentioned in the present study indicates the sum of that from external exposure and that from internally deposited radionuclides. We grouped participants according to estimated absorbed doses in each of 59 municipalities in Fukushima Prefecture, based on The United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) 2013 report. The 59 municipalities were assigned to quartiles by dose. We limited our analyses to participants aged ≥6 years because only one case of thyroid cancer was observed in participants aged ≤5 years; 164 299 participants were included in the final analysis. Compared with the lowest dose quartile, the age- and sex-adjusted rate ratios (95% confidence intervals) for the low-middle, high-middle and highest quartiles were 2.00 (0.84-4.80), 1.34 (0.50-3.59) and 1.42 (0.55-3.67) for the 6-14-year-old groups and 1.99 (0.70-5.70), 0.54 (0.13-2.31) and 0.51 (0.12-2.15) for the >15-year-old group, respectively. No dose-dependent pattern emerged from the geographical distribution of absorbed doses by municipality, as estimated by UNSCEAR, and the detection of thyroid cancer among participants within 4-6 years after the accident. Ongoing surveillance might further clarify the effects of low-dose radiation exposure on thyroid cancer in Fukushima.

国際生活機能分類(ICF)の社会統計としての活用に関する考察 スイス、ドイツの状況と国連障害者権利条約(CRPD)等の観点から
Mar. 2020

A市における高齢者の口腔機能の低下と口腔保健状況・社会的要因との関連　　　　　　　　　　　　　　　
Mar. 2020

Factors Associated with Attrition: Analysis of an HIV Clinic in Japan.
Chieko Hashiba; Mayumi Imahashi; Junji Imamura; Masashi Nakahata; Ayumi Kogure; Hideto Takahashi; Yoshiyuki Yokomaku
Journal of immigrant and minority health, 18 Feb. 2020
This study evaluated the impact of a public medical interpreter on the follow-up clinic attendance rate of foreign-born people with HIV who live in Japan. Participants were patients who visited Nagoya Medical Center from 2009 to 2016. Lost to follow-up was defined as an absence from follow-up visits for more than six months without any notification. A log-rank test was conducted to compare the lost-to-follow-up rates by patients' nation of origin and medical interpreter use. Of the 931 participants, 114 were foreign patients, whose overall attendance rate at 5 years was 75.5%, which was significantly lower than that of Japanese patients (94.1%, p < 0.001). There was no significant difference in regular attendance with respect to medical interpreter use (p = 0.09). Social support in addition to a medical interpreter may be needed to improve attendance rates in the study population.

The Evaluation of the New Guideline for Assessing Image-Defined Risk Factors in the Low-Risk Protocol (JN-L-10) from the Japan Children's Cancer Group Neuroblastoma Committee
A. Yoneda; T. Iehara; I. Yokota; H. Takahashi; S. Teramukai; T. Kamijo; A. Nakazawa; T. Takimoto; A. Kikuta; H. Ikeda; A. Nakagawara; T. Tajiri
PEDIATRIC BLOOD & CANCER, Dec. 2019, [Reviewed]

External Radiation Dose, Obesity, and Risk of Childhood Thyroid Cancer After the Fukushima Daiichi Nuclear Power Plant Accident: The Fukushima Health Management Survey.
Tetsuya Ohira; Akira Ohtsuru; Sanae Midorikawa; Hideto Takahashi; Seiji Yasumura; Satoru Suzuki; Takashi Matsuzuka; Hiroki Shimura; Tetsuo Ishikawa; Akira Sakai; Shinichi Suzuki; Shunichi Yamashita; Susumu Yokoya; Koichi Tanigawa; Hitoshi Ohto; Kenji Kamiya
Epidemiology (Cambridge, Mass.), Nov. 2019
BACKGROUND: The 2011 Great East Japan Earthquake led to a nuclear accident at Fukushima Daiichi Nuclear Power Plant. This study examines the associations of radiation dose and lifestyle factors with incidence of thyroid cancer in Fukushima. METHODS: We designed a prospective study with 300,473 participants aged 18 years or younger, who underwent thyroid examinations from October 2011. Follow-up surveys were conducted through June 2017, and 245,530 participants (123,480 men and 122,050 women, 82% follow-up) received follow-up examinations. Fukushima Prefecture was divided into five areas based on individual external radiation dose. We calculated relative risks and 95% confidence intervals (CIs) for thyroid cancer in each area, with area of lowest dose as reference, using age-adjusted Poisson regression models. We also calculated risks associated with overweight and obesity. RESULTS: The incidence per 100,000 for Groups A (highest dose), B, C, D, and E (lowest dose) were 13.5, 19.2, 17.3, 9.0, and 8.3, respectively. Compared with Group E, the age-adjusted risks (95% CIs) were 1.62 (0.59, 4.47) for group A, 2.32 (0.86, 6.24) for group B, 2.21 (0.82, 5.94) for group C, and 1.02 (0.36, 2.86) for group D. Obesity was positively associated with thyroid cancer incidence; the multivariable-adjusted risk of thyroid cancer was 2.23 (1.01, 4.90) for obese individuals compared with nonobese individuals. CONCLUSION: Regional differences in radiation dose were not associated with increased risk of thyroid cancer among children in Fukushima within 4 to 6 years after the nuclear power plant accident. Obesity may be an important factor for further follow-up in Fukushima.

Results of a prospective clinical trial JN-L-10 using image-defined risk factors to inform surgical decisions for children with low-risk neuroblastoma disease: A report from the Japan Children's Cancer Group Neuroblastoma Committee.
Tomoko Iehara; Akihiro Yoneda; Isao Yokota; Hideto Takahashi; Satoshi Teramukai; Takehiko Kamijyo; Atsuko Nakazawa; Tetsuya Takimoto; Atsushi Kikuta; Shigeki Yagyu; Hitoshi Ikeda; Akira Nakagawara; Tatsuro Tajiri
Pediatric blood & cancer, Nov. 2019, [Reviewed]
BACKGROUND: The present study sought to reduce the incidence of treatment complications of low-risk neuroblastoma by using image-defined risk factors (IDRFs) to inform the timing of surgical resection. PROCEDURES: Eligible patients included children (<18 years of age) with stage 1 or 2 disease, children (<365 days of age) with stage 3 disease, and infants with stage 4S disease. In IDRF-negative cases, treatment was completed with surgical resection alone. In IDRF-positive cases, the timing of surgery was determined based on the IDRFs after low-dose chemotherapy with 2-3 of the following four drugs: vincristine, cyclophosphamide, pirarubicin, and carboplatin. The outcome measures were overall survival, progression-free survival, and adverse events. This study was registered with the UMIN Clinical Trials Registry (number 000004355). RESULTS: Of the 60 patients screened between 2010 and 2013, 58 eligible patients were enrolled; 32 were identified as IDRF negative at diagnosis while 26 were identified as IDRF positive and underwent induction chemotherapy. The 3-year overall and progression-free survival rates of the 58 patients were 100% and 82.8% (95% confidence interval: 70.3-90.3), respectively. Neutropenia was the most frequently reported grade 3 or 4 chemotherapy-related form of toxicity (41.7%). With regard to surgical complications, 2.5% of all patients developed pleural effusion and ascites as early complications, while only 2.5% developed renal atrophy as a long-term complication. No fatal toxicities were observed. CONCLUSION: Using IDRFs to inform surgical decision making for the treatment of low-risk neuroblastoma improved prognosis and reduced the incidence of long-term complications.

Exercise or sports in midlife and healthy life expectancy: an ecological study in all prefectures in Japan.
Takafumi Monma; Fumi Takeda; Haruko Noguchi; Hideto Takahashi; Taeko Watanabe; Nanako Tamiya
BMC public health, 09 Sep. 2019
BACKGROUND: With the increase of overall life expectancy in Japan, effective and beneficial lifestyle approaches and practices are crucial for individuals to have a long, productive and healthy life. Although previous studies suggest that exercise or sports, especially when performed with others, from midlife level have a positive impact on enhancing healthy life expectancy, there is paucity of information regarding these contexts and possible associations. The present study intends to clarify the relationship between engagement in exercise or sports among middle-aged persons and healthy life expectancy through an ecological study in all prefectures in Japan. METHODS: We tabulated (1) the ratios of middle-aged individuals engaged in exercise or sports and (2) the different methods by which they are engaged in exercise or sports for each prefecture by using data from the 2005-2010 Longitudinal Survey of Middle-aged and Elderly Persons by the Ministry of Health, Labour and Welfare of Japan. Weighted multiple linear regression analyses were performed by sex, using healthy life expectancy in 2010 of each prefecture calculated by Hashimoto (2013) as a criterion variable; indices of (1) and (2) of each year as explanatory variables; and age, living conditions, employment, and chronic diseases as adjusted variables. RESULTS: For middle-aged males, the ratio of those engaged in exercise or sports in each year from 2005 to 2010 was positively correlated with healthy life expectancy; this relationship was found in the ratio of middle-aged engaging in exercise or sports "with families or friends". For females, such a relationship could only be found in the ratio of middle-aged females engaged in exercise or sports in 2008 and 2010, and those engaging in exercise or sports "with families or friends" in 2008. CONCLUSION: Prefectures with a higher ratio of middle-aged individuals engaging in exercise or sports, especially when done with families or friends, have longer healthy life expectancies. This was particularly evident for males. Thus, exercise or sports with families or friends in midlife seems to be more effective in promoting healthy life expectancy for males than females in Japan.

Receiving the home care service offered by certified care workers prior to a patients' death and the probability of a home death: observational research using an instrumental variable method from Japan.
Kazuhiro Abe; Atsushi Miyawaki; Yasuki Kobayashi; Haruko Noguchi; Hideto Takahashi; Nanako Tamiya
BMJ open, 27 Aug. 2019, [Reviewed]
OBJECTIVES: To assess the association between receiving the certified care workers' home care service, which is provided by non-medical professionals prior to a patients' death and the probability of a home death. DESIGN: Observational research using the full-time translated number of certified care workers providing home care service per member of the population aged 65 or above, during the year prior to patient's death per municipality as an instrumental variable. SETTING: The certified care workers' home care service covered by the public long-term care insurance (LTCI) system in Japan. PARTICIPANTS: In total, 1 613 391 LTCI beneficiaries aged 65 or above who passed away, except by an external cause of death, between January 2010 and December 2013 were included in the analysis. PRIMARY OUTCOME MEASURES: Death at home or death at other places, including hospitals, nursing homes and clinics with beds. RESULTS: Out of all participants, 173 498 (10.8%) died at home. The number of patients who used the certified care workers' home care service more than once per each month during 1, 2 or 3 months prior to the month of death numbered 213 848, 176 686 and 155 716, respectively. This was associated with an increased probability of death at home by 9.1% points (95% CI 2.9 to 15.3), 10.5% points (3.3 to 17.6) and 11.4% points (3.6 to 19.2), respectively. CONCLUSIONS: The use of the certified care workers' home care service prior to death was associated with the increased probability of a home death.

Incidence of Thyroid Cancer Among Children and Young Adults in Fukushima, Japan-Reply.
Akira Ohtsuru; Hideto Takahashi; Kenji Kamiya
JAMA otolaryngology-- head & neck surgery, 13 Jun. 2019, [Reviewed]

全国の介護保険レセプトを用いた在宅介護のフォーマルケア時間推計
Jun. 2019, [Reviewed]

認知症の要介護者における介護サービスの利用に伴う自己負担額に関する研究―国民生活基礎調査介護票をもとにー　　　　　　　　　　　　　　　
河野, 禎之; 山中, 克夫; 伊藤 智子; 野口 晴子; 高橋 秀人; 田宮 菜奈子
Journal of health and welfare statistics, May 2019, [Reviewed]

The associations of multimorbidity with the sum of annual medical and long-term care expenditures in Japan.
Mori T; Hamada S; Yoshie S; Jeon B; Jin X; Takahashi H; Iijima K; Ishizaki T; Tamiya N
BMC geriatrics, Mar. 2019, [Reviewed]

[Estimation of duration of formal long-term care among frail elderly people in Japanese communities using national long-term care insurance claims records].
Mikiya Sato; Nanako Tamiya; Tomoko Ito; Hideto Takahashi; Haruko Noguchi
[Nihon koshu eisei zasshi] Japanese journal of public health, 2019
Objective The aim of this nationwide study was to estimate the duration of formal long-term care, provided by Japanese long-term care insurance (LTCI) services, among frail Japanese elderly people living in the community.Methods The study subjects were 2,188,397 (men: 579,422, women: 1,124,022, age≥65 years) beneficiaries who used LTCI services for community living in June 2013. The duration of LTCI services for community living per diem per capita was estimated by converting the benefit amount to duration of care using the code for service in claims bills according to gender and care levels, which are a nationally certified classification of individual needs for long-term care (care level 1: lowest need, care level 5: highest need). Subsequently, LTCI services for community living were categorized into respite services and community services. Community services were further subcategorized into home visiting services and daycare services.Results The overall average duration of formal care per diem per capita for men and women were 97.4 and 112.7 minutes for care level 1, 118.3 and 149.1 for care level 2, 186.9 and 246.4 for care level 3, 215.2 and 273.2 for care level 4, and 213.1 and 261.4 for care level 5, respectively. Length of respite services increased gradually with care level, whereas duration of community services peaked at care level 3 and decreased at care levels 4 and 5. With regard to the community service subcategories, duration of home visiting services increased with care level, but duration of daycare services peaked at care level 3.Conclusion Although the care levels in the LCTI system are designed to assess the need for formal care in terms of duration of care, our results suggest that the use of formal LTCI services for community living is not vertically equitable. Services that efficiently increase duration of formal care for those with higher needs for care may improve the equity and sustainability of formal long-term care services for community living.

How do cardiovascular diseases harm labor force participation? Evidence of nationally representative survey data from Japan, a super-aged society.
Rong Fu; Haruko Noguchi; Shuhei Kaneko; Akira Kawamura; Cheolmin Kang; Hideto Takahashi; Nanako Tamiya
PloS one, 2019
OBJECTIVE: To evaluate how cardiovascular diseases harm labor force participation (LFP) among the Japanese population and verify the validity of plasma biomarkers as instrumental variables of cardiovascular diseases after adjusting for a broad set of confounders including dietary intake. DESIGN: Using nationally representative repeated cross-sectional surveys in Japan, the Comprehensive Survey of Living Conditions and National Health and Nutrition Survey, with plasma biomarkers as instrumental variables for quasi-randomization. SETTING: Onset of cardiovascular diseases in those receiving regular treatment for hypertension, intracerebral hemorrhage, intracerebral infarction, angina pectoris, myocardial infarction, or other types of cardiovascular diseases. PARTICIPANTS: A total of 65,615 persons aged ≥ 20 years (35,037 women and 30,578 men) who completed a survey conducted every three years from 1995 through 2013. MAIN OUTCOME MEASURES: Respondent employment and weekly working hours during each survey year. RESULTS: Cardiovascular diseases significantly and remarkably reduced the probability of working by 15.4% (95% CI: -30.6% to -0.2%). The reduction in working probability was detected for women only. Respondents aged ≥ 40 years were less likely to work once diagnosed and the reduction was enlarged for those aged ≥ 65 years, while those aged < 40 years appeared to be unaffected. Probability of engaging in manual labor significantly decreased once diagnosed; however, no impact was found for cognitive occupations. Among employed respondents, the adverse effects of cardiovascular diseases decreased working hours by five hours per week. Validity of the biomarker instrumental variables was generally verified. CONCLUSIONS: A vicious circle is suggested between LFP and unfavorable health. However, the effects vary across age, sex, and occupation type, even after adjusting for causal effects, which could cause a downward bias in LFP impact. ATTRIBUTES: cardiovascular disease, labor force participation, instrumental variable method as quasi-randomization, plasma biomarker, Comprehensive Survey of Living Conditions, National Health and Nutrition Survey.

Incidence of Thyroid Cancer Among Children and Young Adults in Fukushima, Japan, Screened With 2 Rounds of Ultrasonography Within 5 Years of the 2011 Fukushima Daiichi Nuclear Power Station Accident.
Ohtsuru A; Midorikawa S; Ohira T; Suzuki S; Takahashi H; Murakami M; Shimura H; Matsuzuka T; Yasumura S; Suzuki SI; Yokoya S; Hashimoto Y; Sakai A; Ohto H; Yamashita S; Tanigawa K; Kamiya K
JAMA otolaryngology-- head & neck surgery, Jan. 2019
Importance: Ultrasonographic (US) screening for thyroid cancer was performed in the Fukushima Health Management Survey after the 2011 Fukushima Daiichi nuclear power station accident. Clinical characteristics of thyroid cancers screened by US among children and young adults during the first 5 years after the accident were analyzed. Objectives: To evaluate the number of detected thyroid cancers by age group within 5 years of the Fukushima Daiichi nuclear power station accident and to compare the basic clinical characteristics and demographic patterns in first- and second-round examinations. Design, Setting, and Participants: In this observational study, 324 301 individuals 18 years or younger at the time of accident were included. Patients received a cytologic diagnosis of malignant or suspected malignant thyroid cancer during the first (fiscal years 2011-2013) or second round (fiscal years 2014-2015) of screening. Number of detected cases of cancer was evaluated, correcting for the number of examinees by age group at the time of the accident and for the incidence of detected cancers according to age group at the time of the screening (age groups were divided into 3-year intervals). Results were compared using the age-specific incidence of unscreened cancers from a national cancer registry. Main Outcomes and Measures: Clinical baseline characteristics of the patients and the age-specific number and incidence of thyroid cancers detected during the second round. Results: Among 299 905 individuals screened in the first round (50.5% male; mean [SD] age at screening, 14.9 [2.6] years), malignant or suspected thyroid cancer was diagnosed in 116. Among 271 083 individuals screened in the second round (50.4% male; age at screening, 12.6 [3.2] years), malignant or suspected thyroid cancer was diagnosed in 71. The most common pathologic diagnosis in surgical cases was papillary thyroid cancer (149 of 152 [98.0%]). The distribution pattern by age group at the time of the accident, where the number of detected thyroid cancer cases was corrected by the number of examinees, increased with older age in both screening rounds. This demographic pattern was similar between the first and second examinations. The distribution pattern of the incidence rate by age group at the time of screening in the second round also increased with older age. The incidence rate detected by screening was 29 cases per 100 000 person-years for those aged 15 to 17 years, 48 cases per 100 000 person-years for those aged 18 to 20 years, and 64 cases per 100 000 person-years for those aged 21 to 22 years. Conclusions and Relevance: Large-scale mass US screening of young people resulted in the diagnosis of a number of thyroid cancers, with no major changes in overall characteristics within 5 years of the 2011 Fukushima nuclear power station accident. These results suggest that US screening can identify many detectable cancers from a large pool of nonclinical and subclinical thyroid cancers among individuals of a relatively young age, in an age-dependent manner.

Spatial analysis of the geographical distribution of thyroid cancer cases from the first-round thyroid ultrasound examination in Fukushima Prefecture.
Nakaya T; Takahashi K; Takahashi H; Yasumura S; Ohira T; Ohto H; Ohtsuru A; Midorikawa S; Suzuki S; Shimura H; Yamashita S; Tanigawa K; Kamiya K
Scientific Reports, Dec. 2018, [Reviewed]
Following the Fukushima Daiichi Nuclear Power Plant (FNPP) accident on 11 March 2011, there have been concerns regarding the health impacts of the ensuing radioactive environmental contamination, which was spatially heterogeneous. This study aimed to assess the geographical variability of thyroid cancer prevalence among children and adolescents in Fukushima Prefecture. We computed the sex- and age-standardised prevalence ratio using 115 diagnosed or suspected thyroid cancer cases among approximately 300,000 examinees at the first-round ultrasound examination during 2011-2015 from 59 municipalities in the prefecture, under the Fukushima Health Management Survey. We applied flexibly shaped spatial scan statistics and the maximised excess events test on the dataset to detect locally anomalous high-prevalence regions. We also conducted Poisson regression with selected regional indicators. Furthermore, approximately 200 examinees showed positive ultrasound examination results but did not undergo confirmatory testing; thus, we employed simulation-based sensitivity tests to evaluate the possible effect of such undiagnosed cases in the statistical analysis. In conclusion, this study found no significant spatial anomalies/clusters or geographic trends of thyroid cancer prevalence among the ultrasound examinees, indicating that the thyroid cancer cases detected are unlikely to be attributable to regional factors, including radiation exposure resulting from the FNPP accident.

The Authors Respond.
Ohira T; Takahashi H; Yasumura S
Epidemiology (Cambridge, Mass.), Nov. 2018, [Reviewed]

Results of a phase II trial for high-risk neuroblastoma treatment protocol JN-H-07: a report from the Japan Childhood Cancer Group Neuroblastoma Committee (JNBSG).
Tomoro Hishiki; Kimikazu Matsumoto; Miki Ohira; Takehiko Kamijo; Hiroyuki Shichino; Tatsuo Kuroda; Akihiro Yoneda; Toshinori Soejima; Atsuko Nakazawa; Tetsuya Takimoto; Isao Yokota; Satoshi Teramukai; Hideto Takahashi; Takashi Fukushima; Takashi Kaneko; Junichi Hara; Michio Kaneko; Hitoshi Ikeda; Tatsuro Tajiri; Akira Nakagawara
International journal of clinical oncology, Oct. 2018, [Reviewed]
BACKGROUND: The Japanese Children's Cancer Group (JCCG) Neuroblastoma Committee (JNBSG) conducted a phase II clinical trial for high-risk neuroblastoma treatment. We report the result of the protocol treatment and associated genomic aberration studies. METHODS: JN-H-07 was a single-arm, late phase II trial for high-risk neuroblastoma treatment with open enrollment from June 2007 to February 2009. Eligible patients underwent five courses of induction chemotherapy followed by high-dose chemotherapy with hematopoietic stem cell rescue. Surgery for the primary tumor was scheduled after three or four courses of induction chemotherapy. Radiotherapy was administered to the primary tumor site and to any bone metastases present at the end of induction chemotherapy. RESULTS: The estimated 3-year progression-free and overall survival rates of the 50 patients enrolled were 36.5 ± 7.0 and 69.5 ± 6.6%, respectively. High-dose chemotherapy caused severe toxicity including three treatment-related deaths. In response to this, the high-dose chemotherapy regimen was modified during the trial by infusing melphalan before administering carboplatin and etoposide. The modified high-dose chemotherapy regimen was less toxic. Univariate analysis revealed that patients younger than 547 days and patients whose tumor showed a whole chromosomal gains / losses pattern had a significantly poor prognosis. Notably, the progression-free survival of cases with MYCN amplification were not inferior to those without MYCN amplification. CONCLUSIONS: The outcome of patients treated with the JN-H-07 protocol showed improvement over the results reported by previous studies conducted in Japan. Molecular and genetic profiling may enable a more precise stratification of the high-risk cohort.

中年者における運動・スポーツの具体的実施方法と健康寿命との関係　　　　　　　　　　　　　　　
門間, 貴史; 野口, 晴子; 高橋, 秀人; 田宮, 菜奈子; 武田, 文
日本公衆衛生雑誌, Oct. 2018, [Reviewed]

Relationship between social engagement and diabetes incidence in a middle-aged population: Results from a longitudinal nationwide survey in Japan.
Shibayama T; Noguchi H; Takahashi H; Tamiya N
Journal of diabetes investigation, Sep. 2018, [Reviewed]

Household income relationship with health services utilization and healthcare expenditures in people aged 75 years or older in Japan: A population-based study using medical and long-term care insurance claims data.
Hamada S; Takahashi H; Sakata N; Jeon B; Mori T; Iijima K; Yoshie S; Ishizaki T; Tamiya N
Journal of epidemiology, Sep. 2018, [Reviewed]

Associations Between Childhood Thyroid Cancer and External Radiation Dose After the Fukushima Daiichi Nuclear Power Plant Accident.
Ohira T; Takahashi H; Yasumura S; Ohtsuru A; Midorikawa S; Suzuki S; Matsuzuka T; Shimura H; Ishikawa T; Sakai A; Yamashita S; Tanigawa K; Ohto H; Kamiya K; Suzuki S; Fukushima Health Management; Survey Group
Epidemiology (Cambridge, Mass.), Jul. 2018, [Reviewed]

Associations of disaster-related and psychosocial factors with changes in smoking status after a disaster: a cross-sectional survey after the Great East Japan Earthquake.
Hironori Nakano; Tetsuya Ohira; Masaharu Maeda; Hirooki Yabe; Akira Ohtsuru; Yuriko Suzuki; Mayumi Harigane; Naoko Horikoshi; Masato Nagai; Wen Zhang; Hideto Takahashi; Seiji Yasumura; Hiroyasu Iso; Kenji Kamiya
BMJ open, 30 Jun. 2018, [Reviewed]
OBJECTIVE: Few studies have comprehensively examined changes in smoking status and related factors after a disaster. We examined these factors among residents of an evacuation area in Fukushima after the Great East Japan Earthquake. METHODS: The study participants included 58 755 men and women aged ≥20 years who participated in the Fukushima Health Management Survey in 2012 after the disaster. Smoking status was classified as either current smokers or current non-smokers before and after the disaster. The participants were divided into the following groups: (1) non-smokers both before and after the disaster, (2) non-smokers before and smokers after the disaster, (3) smokers before and non-smokers after the disaster and (4) smokers both before and after the disaster. The adjusted prevalence ratios and 95% CIs of changes in smoking status for demographic, disaster-related and psychosocial factors were tested using logistic regression analysis that was stratified by smoking status before the disaster. RESULTS: Among the 44 729 participants, who were non-smokers before the disaster, 634 (1.4%) began smoking after the disaster. Among the 14 025 smokers before the disaster, 1564 (11.1%) quit smoking after the disaster, and the proportion of smokers in the evacuation area consequently decreased from 21.2% to 19.6%. In the multivariable model, factors significantly associated with beginning smoking included being a male, being younger, having a lower education, staying in a rental house/apartment, house being damaged, having experienced a tsunami, change jobs and the presence of traumatic symptoms and non-specific psychological distress. On the contrary, factors associated with quitting smoking included being a female, being older, having a higher education and having a stable income. CONCLUSION: The proportion of smokers slightly decreased among residents in the evacuation area. The changes in smoking statuses were associated with disaster-associated psychosocial factors, particularly changes in living conditions, having experienced a tsunami, change jobs and developing post-traumatic stress disorder.

Comprehensive Assessment of Risk Factors of Cause-Specific Infant Deaths in Japan.
Yamaoka Y; Morisaki N; Noguchi H; Takahashi H; Tamiya N
Journal of epidemiology, Jun. 2018, [Reviewed]

Impact of prestorage leukoreduction of autologous whole blood on length of hospital stay with a subgroup analysis in bilateral hip arthroplasty
Sawamura Y; Ohto H; Ikeda K; Kanno T; Suzuki Y; Gonda K; Tasaki T; Nollet KE; Takahashi H; Aota S
Vox Sanguinis, Jun. 2018, [Reviewed]

Resident and facility characteristics associated with care-need level deterioration in long-term care welfare facilities in Japan
Xueying Jin; Nanako Tamiya; Boyoung Jeon; Akira Kawamura; Hideto Takahashi; Haruko Noguchi
Geriatrics and Gerontology International, 01 May 2018, [Reviewed]

Impact of evacuation onstrends in the prevalence, treatment, and control of hypertension before and after a disaster.
Nagai M; Ohira T; Takahashi H; Nakano H; Sakai A; Hashimoto S; Yasumura S; Abe M; Fukushima Health; Management Survey
Journal of hypertension, Apr. 2018
OBJECTIVE: After the Great East Japan Earthquake in 2011, the prevalence of cardiovascular disease risk factors increased in victims. We examined the trends in the prevalence, treatment, and control of hypertension before and after the disaster, as well as the impact of evacuation. METHODS: Study participants were approximately 10 000 men and 12 000 women aged 40-74 years in each year from 2008 to 2014. All of the participants had lived in radiation evacuation zones prior to the Fukushima nuclear crisis. The age-standardized prevalence, treatment, and control of hypertension were calculated using the direct method. In a comparison of evacuees with nonevacuees, the proportion ratios and 95% confidence intervals for hypertension, treatment, and control were calculated by Poisson regression with robust error variance adjusted for covariates in each year after the disaster. RESULTS: The age-standardized prevalence of hypertension peaked in 2012 at 48.8% in men and 39.0% in women. By 2014, the treatment and control of hypertension had increased to 66.3 and 67.1% in men, and 70.6 and 68.1% in women, respectively. The multiadjusted proportion ratios for the prevalence, treatment, and control of hypertension in any given year were 1.02-1.03, 0.99-1.05, and 0.93-1.06 in men, and 0.96-1.00, 0.99-1.05, and 1.06-1.11 in women, respectively. CONCLUSION: The prevalence of hypertension peaked 1 year after the disaster, while the treatment and control of hypertension increased thereafter. These results indicate that evacuation had little to no impact on the prevalence, treatment, and control of hypertension in the population of Fukushima Prefecture.

Findings of Thyroid Ultrasound Examination Within 3 Years After the Fukushima Nuclear Power Plant Accident: The Fukushima Health Management Survey.
Hiroki Shimura; Tomotaka Sobue; Hideto Takahashi; Seiji Yasumura; Tetsuya Ohira; Akira Ohtsuru; Sanae Midorikawa; Satoru Suzuki; Toshihiko Fukushima; Shinichi Suzuki; Shunichi Yamashita; Hitoshi Ohto
The Journal of clinical endocrinology and metabolism, 01 Mar. 2018
Context: Childhood thyroid cancer is of great concern after the Fukushima nuclear power plant accident. Baseline analytical data on thyroid ultrasound examination (TUE) in children are important for future studies. Objective: We analyzed the age and sex distribution of findings from the TUEs of children and adolescents in the Fukushima Health Management Survey (FHMS). Design, Setting, and Participants: From October 2011 through March 2014, 294,905 participants aged 18 years or younger at the time of the earthquake voluntarily had TUEs in the first round of the FHMS. A secondary confirmatory examination was performed in 2032 subjects. Age- and sex-dependent prevalence and size of thyroid cysts, nodules, and cancers were analyzed. Main Outcome Measures: Age, sex, and size distribution of findings were analyzed. Results: Thyroid cysts, nodules, and cytologically suspected cancers were detected in 68,009, 1415, and 38 male subjects and in 73,014, 2455, and 74 female subjects, respectively. There was an age-dependent increase in the detection rate of thyroid nodules and cancer, but that of cysts reached a peak at 11 to 12 years. Sex affected the prevalence of thyroid nodules and cancers after the onset of puberty, but only a small difference was exhibited in that of cysts. Conclusions: The thyroid cancer detection rate in Fukushima was clarified, and the proportion of individuals with thyroid nodules and cysts varied substantially by age. The results of this study will contribute to future epidemiological research on nodular thyroid diseases in children and adolescents.

Lifestyle factors and social ties associated with the frequency of laughter after the Great East Japan Earthquake: Fukushima Health Management Survey.
Hirosaki M; Ohira T; Yasumura S; Maeda M; Yabe H; Harigane M; Takahashi H; Murakami M; Suzuki Y; Nakano H; Zhang W; Uemura M; Abe M; Kamiya K; Fukushima Health Management; Survey Group
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, Mar. 2018
© 2017 Springer International Publishing AG, part of Springer Nature Purpose: Although mental health problems such as depression after disasters have been reported, positive psychological factors after disasters have not been examined. Recently, the importance of positive affect to our health has been recognised. We therefore investigated the frequency of laughter and its related factors among residents of evacuation zones after the Great East Japan Earthquake of 2011. Methods: In a cross-sectional study on 52,320 participants aged 20 years and older who were included in the Fukushima Health Management Survey in Japan’s fiscal year 2012, associations of the frequency of laughter with changes in lifestyle after the disaster, such as a changed work situation, the number of family members, and the number of address changes, and other sociodemographic, psychological, and lifestyle factors were examined using logistic regression analysis. The frequency of laughter was assessed using a single-item question: “How often do you laugh out loud?” Results: The proportion of those who laugh almost every day was 27.1%. Multivariable models adjusted for sociodemographic, psychological, and

Comprehensive assessment of risk factors for causespecific deaths among Japanese infants using linked Birth and Death data from Vital statistics in 2003-2010　　　　　　　　　　　　　　　
Yui Yamaoka; Naho Morisaki; Haruko Noguchi; Hideto Takahashi; Nanako Tamiya
Journal of Epidemiology, Feb. 2018, [Reviewed]

Effect of short-stay service use on stay-at-home duration for elderly with certified care needs: Analysis of long-term care insurance claims data in Japan.
Moriyama Y; Tamiya N; Kawamura A; Mayers TD; Noguchi H; Takahashi H
PloS one, 2018, [Reviewed]

Comparative Analysis of the Growth Pattern of Thyroid Cancer in Young Patients Screened by Ultrasonography in Japan After a Nuclear Accident: The Fukushima Health Management Survey.
Midorikawa S; Ohtsuru A; Murakami M; Takahashi H; Suzuki S; Matsuzuka T; Shimura H; Ohira T; Suzuki SI; Yasumura S; Yamashita S; Ohto H; Tanigawa K; Kamiya K
JAMA otolaryngology - head & neck surgery, Jan. 2018
Importance: Thyroid cancer generally grows at a very slow rate in adults, and overdiagnosis is a global issue. However, the detection of early-stage thyroid cancer by screening is not well described in young patients. To prevent overdiagnosis, it is essential to understand the natural course of thyroid cancer growth detection by ultrasonography screening in young patients. Objective: To evaluate the natural progression of thyroid cancer in young patients. Design, Setting, and Participants: An observational study evaluated changes in the diameter of malignant or suspected malignant thyroid tumors on 2 occasions. Changes in malignant thyroid tumor diameter were estimated during the observation period between the screening and confirmatory examinations in the first-round thyroid ultrasonography examination of the Fukushima Health Management Survey in patients younger than 21 years after a nuclear accident at a power plant in Fukushima, Japan. In total, 116 patients cytologically diagnosed with or suspected to have thyroid cancer were classified into 3 groups based on a greater than 10% reduction, a change of -10% to +10% in diameter, and a greater than 10% increase in tumor diameter. The association between tumor growth rate and tumor diameter was analyzed. The study was conducted from March 1, 2016, to August 6, 2017. Main Outcomes and Measures: Tumor volume changes, the coefficient of growth of thyroid cancer in young patients, and the association between the observation period or tumor diameter and them. Results: Of 116 patients, 77 were female; the mean age was 16.9 years (median, 17.5 years). The mean observation period was 0.488 (range, 0.077-1.632) years. No significant differences in age, sex, tumor diameter, observation period, or serum levels of thyrotropin and thyroglobulin were observed among the groups. Whereas tumor volume changes were not linearly correlated with the observation period (Pearson R = 0.121; 95% CI, -0.062 to 0.297), the coefficient of growth was significantly and negatively correlated with the tumor diameter in the screening examination (Spearman ρ = -0.183; 95% CI, -0.354 to -0.001), suggesting growth arrest after the initial proliferation phase. Conclusions and Relevance: Ultrasonography screening could reveal asymptomatic thyroid cancer that is falling into a growth arrest pattern in many young patients. Considering the long life expectancy, prevention of overdiagnosis necessitates careful long-term monitoring without immediate diagnosis for suspected noninvasive thyroid cancer.

The Association between Continuation of Home Medical Care and Utilization of Other Home Care Services for Older People with Long-term Care Insurance in Japan
Kazuhiro Abe; Yasuki Kobayashi; Akira Kawamura; Haruko Noguchi; Hideto Takahashi; Nanako Tamiya
An Official Journal of the Japan Primary Care Association, 2018, [Reviewed]

Simulation of expected childhood and adolescent thyroid cancer cases in Japan using a cancer-progression model based on the National Cancer Registry
Hideto Takahashi; Kunihiko Takahashi; Hiroki Shimura; Seiji Yasumura; Satoru Suzuki; Akira Ohtsuru; Sanae Midorikawa; Tetsuya Ohira; Hitoshi Ohto; Shunichi Yamashita; Kenji Kamiya
Medicine, Dec. 2017, [Reviewed]

福島県県民健康調査「甲状腺検査」の先行検査における甲状腺嚢胞と結節の性別および年齢階級別疫学的特徴
Dec. 2017

The impact of evacuation on the incidence of chronic kidney disease after the Great East Japan Earthquake: The Fukushima Health Management Survey.
Yoshimitsu Hayashi; Masato Nagai; Tetsuya Ohira; Hiroaki Satoh; Akira Sakai; Akira Ohtsuru; Mitsuaki Hosoya; Yukihiko Kawasaki; Hitoshi Suzuki; Atsushi Takahashi; Yoshihiro Sugiura; Hiroaki Shishido; Hideto Takahashi; Seiji Yasumura; Junichiro James Kazama; Shigeatsu Hashimoto; Gen Kobashi; Kotaro Ozasa; Masafumi Abe
Clinical and experimental nephrology, Dec. 2017
BACKGROUND: About 146,000 people were forced into long-term evacuation due to the nuclear power plant accident caused by the Great East Japan Earthquake in 2011. Disaster is known to induce hypertension in survivors for a certain period, but it is unclear whether prolonged disaster stress influences chronic kidney disease (CKD). We conducted an observational cohort study to elucidate the effects of evacuation stress on CKD incidence. METHODS: Participants were individuals living in communities near the Fukushima nuclear power plant, aged 40-74 years without CKD as of their 2011 general health checkup (non-evacuees: n = 9780, evacuees: n = 4712). We followed new-onset CKD [estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m2 or proteinuria] using general annual health checkup data from 2012 to 2014. Association between evacuation and CKD incidence was analyzed using the Cox proportional hazard model. RESULTS: Mean age of the participants at baseline was 65 years, 46.7% were men, and baseline eGFR was 75.7 ml/min/1.73 m2. During the mean follow-up period of 2.46 years, CKD incidence rate was 80.8/1000 and 100.2/1000 person-years in non-evacuees and evacuees, respectively. Evacuation was a significant risk factor of CKD incidence after adjusting for age, gender, obesity, hypertension, diabetes, dyslipidemia, smoking, and baseline eGFR [hazard ratio (HR): 1.45; 95% confidence interval (CI) 1.35-1.56]. Evacuation was significantly associated with the incidence of eGFR <60 ml/min/1.73 m2 (HR: 1.48; 95% CI 1.37-1.60), but not with the incidence of proteinuria (HR: 1.21; 95% CI 0.93-1.56). CONCLUSION: Evacuation was a risk factor associated with CKD incidence after the disaster.

Spillover effect of Japanese long-term care insurance as an employment promotion policy for family caregivers.
Rong Fu; Haruko Noguchi; Akira Kawamura; Hideto Takahashi; Nanako Tamiya
Journal of health economics, Dec. 2017
We evaluate a spillover effect of the Japanese public long-term care insurance (LTCI) as a policy to stimulate family caregivers' labor force participation. Using nationally representative data from 1995 to 2013, we apply difference-in-difference propensity score matching to investigate the spillover effect in two periods: before and after the introduction of the LTCI in 2000 and before and after its major amendment in 2006. Our results show that the LTCI introduction has significant and positive spillover effects on family caregivers' labor force participation and the effects vary by gender and age. In contrast, the LTCI amendment is found to have generally negative spillover effects on their labor force participation. We draw attention to these spillover effects, as expanding labor market supply to sustain the economy would be a priority for Japan and other rapidly aging countries in the coming decades.

地域包括ケアシステムの評価指標としての在宅期間-8年間の全国介護レセプトデータによる検討
植嶋 大晃; 高橋 秀人; 野口 晴子; 川村 顕; 松本 吉央; 森山 葉子; Tamiya, Nanako
厚生の指標, Dec. 2017, [Reviewed]

Impact of long-hours family caregiving on non-fatal coronary heart disease risk in middle-aged people: Results from a longitudinal nationwide survey in Japan
Atsushi Miyawaki; Jun Tomio; Yasuki Kobayashi; Hideto Takahashi; Haruko Noguchi; Nanako Tamiya
Geriatrics & Gerontology International, Nov. 2017, [Reviewed]

Perception of Radiation Risk as a Predictor of Mid-Term Mental Health after a Nuclear Disaster: The Fukushima Health Management Survey.
Miura I; Nagai M; Maeda M; Harigane M; Fujii S; Oe M; Yabe H; Suzuki Y; Takahashi H; Ohira T; Yasumura S; Abe M
International journal of environmental research and public health, 15 Sep. 2017

Representativeness of individual external doses estimated for one quarter of residents in the Fukushima Prefecture after the nuclear disaster: the Fukushima Health Management Survey
Tetsuo Ishikawa; Hideto Takahashi; Seiji Yasumura; Akira Ohtsuru; Tetsuya Ohira; Akira Sakai; Ritsu Sakata; Kotaro Ozasa; Keiichi Akahane; Shunsuke Yonai; Osamu Kurihara; Kenji Kamiya; Masafumi Abe
JOURNAL OF RADIOLOGICAL PROTECTION, Sep. 2017, [Reviewed]

Perception of Radiation Risk as a Predictor of Mid-Term Mental Health after a Nuclear Disaster: The Fukushima Health Management Survey
Itaru Miura; Masato Nagai; Masaharu Maeda; Mayumi Harigane; Senta Fujii; Misari Oe; Hirooki Yabe; Yuriko Suzuki; Hideto Takahashi; Tetsuya Ohira; Seiji Yasumura; Masafumi Abe
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, Sep. 2017, [Reviewed]

Changes in mortality inequalities across occupations in Japan: a national register based study of absolute and relative measures, 1980-2010
Hirokazu Tanaka; Satoshi Toyokawa; Nanako Tamiya; Hideto Takahashi; Haruko Noguchi; Yasuki Kobayashi
BMJ OPEN, Sep. 2017, [Reviewed]

国民生活基礎調査に基づいた高齢者の飲酒実態の把握　　　　　　　　　　　　　　　
Aug. 2017

Prevalence and Characterization of Thyroid Hemiagenesis in Japan: The Fukushima Health Management Survey.
Satoru Suzuki; Sanae Midorikawa; Takashi Matsuzuka; Toshihiko Fukushima; Yuko Ito; Hiroki Shimura; Hideto Takahashi; Tetsuya Ohira; Akira Ohtsuru; Masafumi Abe; Shinichi Suzuki; Shunichi Yamashita
Thyroid : official journal of the American Thyroid Association, Aug. 2017
BACKGROUND: Thyroid hemiagenesis is a rare congenital variant characterized by the lack of development of one thyroid lobe with no clinical manifestations. METHODS: This study was performed to determine the prevalence and characteristics of thyroid hemiagenesis in a normal Japanese population. This cross-sectional study was performed from October 9, 2011, to April 30, 2015. In total, 299,908 children and young adults in the Fukushima Health Management Survey were examined to determine the presence of thyroid agenesis or hemiagenesis. Thyroid width, thickness, and length were measured in 292,452 of these subjects. RESULTS: Thyroid agenesis was diagnosed in 13 subjects, and hemiagenesis was detected in 67 subjects (0.02%; 22.3/100,000 individuals). Although there was no significant sex-related difference (p = 0.067), the female:male ratio was 1.67:1.00. Females were significantly dominant in right hemiagenesis, while there was no difference in left hemiagenesis between males and females. The thyroid volumes at the 2.5th and 97.5th percentiles for age and body surface area were determined for each sex. Multivariate regression analysis showed that a large hemithyroid volume was independently associated with the presence of contralateral hemiagenesis (p < 0.001). CONCLUSION: The prevalence of thyroid hemiagenesis in the present study is in agreement with that reported in other countries. The prevalence of right hemiagenesis was higher in females, and the larger contralateral lobe in patients with rather than without hemiagenesis may have been caused by a compensatory feedback mechanism to prevent hypothyroidism. In addition, the prevalence of hemiagenesis, especially right hemiagenesis, may be affected by sex-related factors similar to those in patients with an ectopic thyroid gland.

Effectiveness of Prehospital Epinephrine Administration in Improving Long-term Outcomes of Witnessed Out-of-hospital Cardiac Arrest Patients with Initial Non-shockable Rhythms
Jun Tomio; Shinji Nakahara; Hideto Takahashi; Masao Ichikawa; Masamichi Nishida; Naoto Morimura; Tetsuya Sakamoto
PREHOSPITAL EMERGENCY CARE, Jul. 2017, [Reviewed]

Effects of socioeconomic factors on cardiovascular-related symptoms among residents in Fukushima after the Great East Japan Earthquake: a cross-sectional study using data from the Fukushima Health Management Survey
Wen Zhang; Tetsuya Ohira; Seiji Yasumura; Masaharu Maeda; Akira Otsuru; Mayumi Harigane; Naoko Horikoshi; Yuriko Suzuki; Hirooki Yabe; Masato Nagai; Hironori Nakano; Mayumi Hirosaki; Mayu Uemura; Hideto Takahashi; Kenji Kamiya; Shunichi Yamashita; Masafumi Abe
BMJ OPEN, Jun. 2017, [Reviewed]

Changes in Hepatobiliary Enzyme Abnormality After the Great East Japan Earthquake: The Fukushima Health Management Survey
Atsushi Takahashi; Tetsuya Ohira; Mayu Uemura; Mitsuaki Hosoya; Seiji Yasumura; Shigeatsu Hashimoto; Hiromasa Ohira; Akira Sakai; Akira Ohtsuru; Hiroaki Satoh; Yukihiko Kawasaki; Hitoshi Suzuki; Yoshihiro Sugiura; Hiroaki Shishido; Yoshimitsu Hayashi; Hideto Takahashi; Hironori Nakano; Gen Kobashi; Kotaro Ozasa; Hitoshi Ohto; Masafumi Abe
SCIENTIFIC REPORTS, Apr. 2017, [Reviewed]

Changes of Posttraumatic Stress Responses in Evacuated Residents and Their Related Factors: A 3-Year Follow-up Study From the Fukushima Health Management Survey
Misari Oe; Hideto Takahashi; Masaharu Maeda; Mayumi Harigane; Senta Fujii; Itaru Miura; Masato Nagai; Hirooki Yabe; Tetsuya Ohira; Yuriko Suzuki; Seiji Yasumura; Masafumi Abe
ASIA-PACIFIC JOURNAL OF PUBLIC HEALTH, Mar. 2017, [Reviewed]

Persistent prevalence of polycythemia among evacuees 4 years after the Great East Japan Earthquake: A follow-up study.
Sakai A; Nakano H; Ohira T; Hosoya M; Yasumura S; Ohtsuru A; Satoh H; Kawasaki Y; Suzuki H; Takahashi A; Sugiura Y; Shishido H; Hayashi Y; Takahashi H; Kobashi G; Ozasa K; Hashimoto S; Ohto H; Abe M; Fukushima Health; Management; Survey Group
Preventive medicine reports, Mar. 2017

Relation between social network and psychological distress among middle-aged adults in Japan: Evidence from a national longitudinal survey
Rong Fu; Harkuo Noguchi; Hirokazu Tachikawa; Miyuki Aiba; Shin Nakamine; Akira Kawamura; Hideto Takahashi; Nanako Tamiya
SOCIAL SCIENCE & MEDICINE, Feb. 2017, [Reviewed]

The Authors Respond.
Hideto Takahashi; Tetsuya Ohira; Akira Ohtsuru; Hiroki Shimura; Kumiko Tsuboi; Seiji Yasumura; Koichi Tanigawa; Sanae Midorikawa; Satoru Suzuki
Epidemiology (Cambridge, Mass.), Jan. 2017

Development of social capital scale from a national longitudinal survey and examination of its validity and reliability.
Miyuki Aiba; Hirokazu Tachikawa; Shin Nakamine; Sho Takahashi; Haruko Noguchi; Hideto Takahashi; Nanako Tamiya
[Nihon koshu eisei zasshi] Japanese journal of public health, 2017, [Reviewed]
Objectives Social capital consists of two subordinate concepts; first one is structural formal, structural informal, or cognitive and second one is bonding or bridging. This study was designed to develop a social capital scale using samples from a national longitudinal survey and evaluate the validity and test-retest reliability of the scale.Methods Data were collected from a nationwide panel survey, the "Longitudinal Survey of Middle-aged and Elderly Persons." Individuals aged 50-59 years living in Japan were selected by stratified random sampling in the first wave conducted in 2005. The first (n=34,240) and second (n=32,285) sets of data were used for Phase 1, and the sixth (n=26,220) and seventh (n=25,321) sets of data were used for Phase 2. In regard to first subordinate concept, the occurrence of six selected social activities with "neighborhood association" and "NPOs, or Public Interest Corporations" were calculated as the structural formal index, and the occurrence of six selected social activities with "families or friends" and "colleagues" were calculated as the structural informal index. Moreover, satisfaction with social activities (community activities, support for the elderly, and others) was used as the cognitive index. In regard to second subordinate concept, the bonding index was calculated using "families or friends," "colleagues," and "neighborhood association;" the bridging index was calculated using "NPOs or Public Interest Corporations." The diagnoses of heart disease, stroke, and cancer (yes=1, no=0) and self-rated health (1 item, 6-point scale) were used as variables for determining validity.Results We categorized social capital indices into subordinate concepts based on the construct of social capital defined by professional agreement to assess content validity. The results showed that this survey questionnaire was constructed using items that assessed all the subordinate concepts. Hierarchical Linear Modeling examined the relationship between social capital and health as assessed by diagnoses of physical disease and self-rated health to examine convergent validity, which indicated that all social capital indices had significant positive effects on self-rated health at an individual or group level. However, the diagnosis of a stroke was negatively influenced by cognitive and formal social capital indices at a group level, whereas heart disease and cancer were not significantly affected. Multilevel correlation analyses of Phase 1 (the first and second) and Phase 2 (sixth and seventh) were conducted to assess test-retest reliability, which indicated correlation coefficients of 0.392 to 0.999.Conclusion The findings of this study indicated the content validity of the scale that was developed from the national longitudinal survey. Moreover, results of Hierarchical Linear Modeling confirmed the partial convergent validity of the scale. Furthermore, multilevel correlation analyses demonstrated the adequate test-retest reliability of the scale at the group level.

Changes in social capital and depressive states of middle-aged adults in Japan.
Shin Nakamine; Hirokazu Tachikawa; Miyuki Aiba; Sho Takahashi; Haruko Noguchi; Hideto Takahashi; Nanako Tamiya
PloS one, 2017, [Reviewed]

Evacuation is a risk factor for diabetes development among evacuees of the Great East Japan earthquake: A 4-year follow-up of the Fukushima Health Management Survey
Satoh H; Ohira T; Nagai M; Hosoya M; Sakai A; Yasumura S; Ohtsuru A; Kawasaki Y; Suzuki H; Takahashi A; Sugiura Y; Shishido H; Hayashi Y; Takahashi H; Kobashi G; Ozasa K; Hashimoto S; Ohto H; Abe M; Kamiya K
Diabetes and Metabolism, 01 Jan. 2017

都道府県別にみた主たる家族介護者である中高年女性の就業および就業希望の状況－平成25年国民生活基礎調査から－
渡邊 多永子; Tamiya, Nanako; 野口 晴子; 高橋 秀人
厚生の指標, 2017, [Reviewed]

Evacuation after the Great East Japan Earthquake was associated with poor dietary intake: The Fukushima Health Management Survey.
Wen Zhang; Tetsuya Ohira; Masafumi Abe; Kenji Kamiya; Shunichi Yamashita; Seiji Yasumura; Akira Ohtsuru; Maeda Masaharu; Mayumi Harigane; Naoko Horikoshi; Yuriko Suzuki; Hirooki Yabe; Michiko Yuuki; Masato Nagai; Hideto Takahashi; Hironori Nakano
Journal of epidemiology, Jan. 2017
BACKGROUND: Few studies have investigated the relationship between living arrangements and dietary intake among evacuees after disasters. OBJECTIVES: To examine the relationship between living arrangements and dietary intake using the data of a large-scale cohort survey of evacuees after the Great East Japan Earthquake in 2011. METHODS: 73,433 residents in evacuation zones responded to the Fukushima Health Management Survey questionnaire. Subjects were excluded if they did not report their living conditions or were missing more than three pieces of information about dietary intake. The data of 52,314 subjects (23,149 men and 29,165 women ≥15 years old) were used for the analyses. Evacuees' living arrangements were characterized into three categories: evacuation shelters or temporary housing, rental houses or apartments, or a relative's home or their own home. Dietary intake was characterized in terms of grains, fruits and vegetables, meat, soybean products, dairy products, and fish. Daily consumption of the third quartile (Q3) or higher for each food group was defined as 'high consumption'. Prevalence ratios (PRs) and 95% confidence intervals (CIs) were estimated using modified Poisson regression analyses. RESULTS: Modified Poisson regression analyses showed that, compared with respondents living in a relative's home or their own home, the PRs and 95% CIs for the people living in rental apartments of high consumption of fruits and vegetables (non-juice), meat, soybean products, and dairy products were 0.69 (95% CI, 0.61-0.77), 0.82 (95% CI, 0.73-0.91), 0.89 (95% CI, 0.83-0.94), and 0.83 (95% CI, 0.74-0.93) respectively. The corresponding PRs and 95% CIs for people living in evacuation shelters or temporary housing were 0.83 (95% CI, 0.78-0.88), 0.90 (95% CI, 0.86-0.95), 0.94 (95% CI, 0.91-0.97), and 0.91 (95% CI, 0.86-0.96) for high consumption of fruits and vegetables (non-juice), meat, soybean products, and dairy products, respectively. CONCLUSION: The present study suggests that, after the earthquake, living in non-home conditions was associated with poor dietary intake of fruits and vegetables (non-juice), meat, soybean products, and dairy products, suggesting the need for early improvements in the provision of balanced meals among evacuees living in non-home conditions.

Environmental risk factors for sudden infant death syndrome in Japan
Masako Hirabayashi; Masao Yoshinaga; Yuichi Nomura; Hiroya Ushinohama; Seiichi Sato; Nobuo Tauchi; Hitoshi Horigome; Hideto Takahashi; Naokata Sumitomo; Hirohiko Shiraishi; Masami Nagashima
EUROPEAN JOURNAL OF PEDIATRICS, Dec. 2016, [Reviewed]

A trial to understand the status of oral migrants using nationally representative long-term claims data (in Japanese)
Akira Kawamura; Nanako Tamiya; Nobuyuki Izumida; Hiroaki Ueshima; Hideto Takahashi; Haruko Noguchi
Journal of health and welfare statistics, Dec. 2016, [Reviewed]

The relationship between raising a child with a disability and the mental health of mothers compared to raising a child without disability in japan.
Yui Yamaoka; Nanako Tamiya; Nobuyuki Izumida; Akira Kawamura; Hideto Takahashi; Haruko Noguchi
SSM - population health, Dec. 2016, [Reviewed]
Objective: Previous studies conducted in Japan targeted only mothers who cared for children with disabilities, and lacked reference subjects, such as mothers of children without disabilities. The aim of this study was to examine the association between raising one or two children with a disability and maternal psychological distress compared to mothers of children without a disability, and to assess differences among partnered mothers living with grandparent(s), partnered mothers without grandparent(s), and single mothers. Methods: This study utilized data from the Comprehensive Survey of Living Conditions (CSLC) in 2010. We merged the data of the children (aged six and over), mothers, and fathers. This study obtained 33,739 study subjects as a triad of a child (33,110 children without disabilities and 629 children with disabilities), mother, and father. The Japanese version of Kessler 6 (K6) was used to assess the psychological distress of mothers. Multivariate logistic regression was performed to assess the independent association of a child with a disability on maternal psychological distress after controlling for the basic characteristics of the children, mothers, and households. Results: This study reported that raising one or two children with disabilities was significantly related to maternal psychological distress (odds ratio: 1.72 for one child, 2.85 for two children) compared to mothers of children without disability. After stratifying the analyses by family structure, significant associations remained among mothers in two-parent families but not for mothers in three-generation families and single mothers due to a small number of children with disabilities in these families. Conclusions: This study reported the significant association between raising a child with a disability and maternal psychological distress in comparison to mothers of children without disabilities. Attention should be paid to not only single mothers, but also partnered mothers in two-parent families who have a child with a disability. It is important for health professionals to focus on the mental health of every mother of a child with a disability and to assess their needs for psychological support.

External and internal exposure to Fukushima residents
Kamiya K; Ishikawa T; Yasumura S; Sakai A; Ohira T; Takahashi H; Ohtsuru A; Suzuki S; Hosoya M; Maeda M; Yabe H; Fujimori K; Yamashita S; Ohto H; Abe M
Radiation Protection Dosimetry, 01 Sep. 2016
© World Health Organisation 2016. All rights reserved. The Great East Japan Earthquake of 11 March 2011, caused the Fukushima Daiichi Nuclear Power Plant Accident, which resulted in the release of a large amount of radioactive materials into the environment, and there is a serious concern about the radiation effects on the health of residents living in the affected areas. The evaluation of exposure dose is fundamental for the estimation of health effects, and whenever possible, the exposure dose should be evaluated by actual measurements as opposed to estimations. Here, the outline of the exposure doses of residents estimated from surveys or obtained by measurements is described. Fukushima Health Management Survey reported the results for 460 408 residents during the first 4 months after the accident; 66.3% received doses < 1 mSv, 94.9% received < 2 mSv, 99.7% received < 5 mSv and the maximum dose was 25 mSv. Thus, it was demonstrated that the results from personal dosemeter measurements were comparable to the estimations. The dose assessment of internal exposure of 184 205 residents conducted by Fukushima Prefecture by using whole body counter showed that 99.986% received < 1

Parental Post-Traumatic Stress Symptoms as Predictors of Psychosocial Problems in Children Treated for Cancer
Ryoko Nakajima-Yamaguchi; Nobuaki Morita; Tomohei Nakao; Takashi Shimizu; Yasukazu Ogai; Hideto Takahashi; Tamaki Saito; Yoji Nakatani; Takashi Fukushima
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, Aug. 2016, [Reviewed]

Comparison of childhood thyroid cancer prevalence among 3 areas based on external radiation dose after the Fukushima Daiichi nuclear power plant accident: The Fukushima health management survey.
Tetsuya Ohira; Hideto Takahashi; Seiji Yasumura; Akira Ohtsuru; Sanae Midorikawa; Satoru Suzuki; Toshihiko Fukushima; Hiroki Shimura; Tetsuo Ishikawa; Akira Sakai; Shunichi Yamashita; Koichi Tanigawa; Hitoshi Ohto; Masafumi Abe; Shinichi Suzuki
Medicine, Aug. 2016
The 2011 Great East Japan Earthquake led to a subsequent nuclear accident at the Fukushima Daiichi Nuclear Power Plant. In its wake, we sought to examine the association between external radiation dose and thyroid cancer in Fukushima Prefecture. We applied a cross-sectional study design with 300,476 participants aged 18 years and younger who underwent thyroid examinations between October 2011 and June 2015. Areas within Fukushima Prefecture were divided into three groups based on individual external doses (≥1% of 5 mSv, <99% of 1 mSv/y, and the other). The odds ratios (ORs) and 95% confidence intervals of thyroid cancer for all areas, with the lowest dose area as reference, were calculated using logistic regression models adjusted for age and sex. Furthermore, the ORs of thyroid cancer for individual external doses of 1 mSv or more and 2 mSv or more, with the external dose less than 1 mSv as reference, were calculated. Prevalence of thyroid cancer for the location groups were 48/100,000 for the highest dose area, 36/100,000 for the middle dose area, and 41/100,000 for the lowest dose area. Compared with the lowest dose area, age-, and sex-adjusted ORs (95% confidence intervals) for the highest-dose and middle-dose areas were 1.49 (0.36-6.23) and 1.00 (0.67-1.50), respectively. The duration between accident and thyroid examination was not associated with thyroid cancer prevalence. There were no significant associations between individual external doses and prevalence of thyroid cancer. External radiation dose was not associated with thyroid cancer prevalence among Fukushima children within the first 4 years after the nuclear accident.

Association between psychological distress and dietary intake among evacuees after the Great East Japan Earthquake in a cross-sectional study: the Fukushima Health Management Survey.
Mayu Uemura; Tetsuya Ohira; Seiji Yasumura; Akira Otsuru; Masaharu Maeda; Mayumi Harigane; Naoko Horikoshi; Yuriko Suzuki; Hirooki Yabe; Hideto Takahashi; Masato Nagai; Hironori Nakano; Wen Zhang; Mayumi Hirosaki; Masafumi Abe
BMJ open, 05 Jul. 2016
OBJECTIVE: Psychological distress is generally associated with poor dietary intake, but this has never been investigated among residents after a major disaster. We attempted to reveal the associations between dietary intake and non-specific mental health distress as well as traumatic symptoms among evacuees after the Great East Japan Earthquake of 2011. METHODS: In this cross-sectional analysis of 63 047 evacuees (27 901 men, 35 146 women) who responded to The Fukushima Health Management Survey in 2012, non-specific mental health distress was assessed using the Kessler-6 (K6) scale, while traumatic symptoms were evaluated using the Post-traumatic Stress Disorder (PTSD) Checklist-Stressor-Specific Version (PCL-S). The outcome was 'low frequency'-meaning a daily consumption in the 25th centile or less according to the food frequency questionnaire (FFQ)-of 19 targeted food items. Logistic regression analysis was used to estimate ORs and 95% CIs adjusted for demographic, lifestyle-related and disaster-related factors. RESULTS: Of the participants, 14.7% suffered non-specific mental health distress, and 21.2% exhibited traumatic symptoms. Multivariable adjusted logistic regression analysis showed that the former were likely to have a low intake frequency of certain foods, such as rice and bread, fish, meat, vegetables or fruit (non-juice), soya bean products, milk, and yogurt or lactobacillus drinks; the latter were also likely to have a low intake frequency of certain foods, including rice and bread, fish, meat, vegetables (non-juice), milk and yogurt or lactobacillus drinks, but conversely consumed vegetable and fruit juices more often. These associations between dietary intake and non-specific mental health distress, as well as traumatic symptoms, were predominantly observed in women. CONCLUSIONS: Psychological distress after the Great East Japan Earthquake among evacuees was associated with a low intake frequency of certain foods, and the association was predominantly observed in women.

避難区域住民の心的外傷後ストレス症状変化と回復関連要因 福島県県民健康調査　　　　　　　　　　　　　　　
Jun. 2016

Comprehensive Survey Results of Childhood Thyroid Ultrasound Examinations in Fukushima in the First Four Years After the Fukushima Daiichi Nuclear Power Plant Accident.
Shinichi Suzuki; Satoru Suzuki; Toshihiko Fukushima; Sanae Midorikawa; Hiroki Shimura; Takashi Matsuzuka; Tetsuo Ishikawa; Hideto Takahashi; Akira Ohtsuru; Akira Sakai; Mitsuaki Hosoya; Seiji Yasumura; Kenneth E Nollet; Tetsuya Ohira; Hitoshi Ohto; Masafumi Abe; Kenji Kamiya; Shunichi Yamashita
Thyroid : official journal of the American Thyroid Association, Jun. 2016
BACKGROUND: Thyroid nodules and cancers are rare in children compared with adults. However, after the 1986 Chernobyl Nuclear Power Plant accident, a rapid increase in childhood thyroid cancer was observed. To avoid any confusion and misunderstanding of data obtained in Fukushima after the 2011 nuclear accident, baseline prevalence of thyroid nodules and cancers should be carefully assessed with standardized criteria systematically, and comprehensively applied to the population perceived to be at risk. AIMS: Under the official framework of the Fukushima Health Management Survey, the thyroids of children in Fukushima were examined using ultrasound, and the results collected in the first four years after the nuclear accident were analyzed in order to establish a baseline prevalence of childhood thyroid abnormalities, especially cancer. SUBJECTS AND METHODS: Of 367,685 people aged 18 years or younger as of April 1, 2011, who were living in Fukushima Prefecture at the time of the accident, 300,476 underwent thyroid ultrasound screening. Of those, 2108 subjects with thyroid nodules were further examined using an advanced ultrasound instrument, with standardized criteria applied to determine the need for fine-needle aspiration cytology (FNAC). FNAC results determined the need for surgery and histological confirmation of the cytological diagnosis. RESULTS: Of the 2108 rescreened subjects, 543 underwent FNAC, of whom 113 were diagnosed with malignancy or suspected malignancy. Subsequently, 99 patients underwent surgical resection, revealing 95 cases of papillary thyroid cancer, three poorly differentiated cancers, and one benign nodule. The overall prevalence of childhood thyroid cancer in Fukushima was determined to be 37.3 per 100,000 with no significant differences between evacuated and non-evacuated areas. Thyroid cancer patients had external exposure estimates of <2.2 mSv during the first four months. CONCLUSIONS: The high prevalence of childhood thyroid cancer detected in this four-year study in Fukushima can be attributed to mass screening. It clearly exceeds what is found incidentally anywhere else. Direct comparisons with any other results, even those from cancer registries, are not meaningful because of differences in methodology.

Three-year trend survey of psychological distress, post-traumatic stress, and problem drinking among residents in the evacuation zone after the Fukushima Daiichi Nuclear Power Plant accident [The Fukushima Health Management Survey].
Misari Oe; Senta Fujii; Masaharu Maeda; Masato Nagai; Mayumi Harigane; Itaru Miura; Hirooki Yabe; Tetsuya Ohira; Hideto Takahashi; Yuriko Suzuki; Seiji Yasumura; Masafumi Abe
Psychiatry and clinical neurosciences, Jun. 2016
AIM: Prolonged periods of instability in terms of living environment can lead to a serious increase in mental health issues among disaster-affected individuals. The aim of this study was to assess long-term trends in mental health among adult residents in a nuclear-disaster-affected area. METHODS: Mail-based, self-administered questionnaire surveys were conducted three times (T1-T3), targeting all residents registered with the municipalities in the evacuation zone in Fukushima prefecture at the time of the disaster. Age-adjusted prevalences of the following were analyzed by sex: risk of psychological distress by the Kessler 6-item Scale, post-traumatic stress by the Post-traumatic Stress Disorder Checklist, and problem drinking by CAGE. RESULTS: The numbers of respondents and response rates were: 73 568, 40.7% (T1); 55 076, 29.9% (T2); and 46 386, 25.0% (T3). Compared with normal Japanese levels in non-disaster settings (4.7%), the prevalence of general psychological distress by Kessler 6-item Scale ≥ 13 was still high 3 years after the event in both men (11.4%) and women (15.8%). Although the age-adjusted prevalence of psychological distress and post-traumatic stress (Post-traumatic Stress Disorder Checklist ≥ 44) had decreased over time (from 19.0% [T1] to 17.8% [T3] for men, and from 25.3% [T1] to 23.3% [T3] for women), the age-adjusted prevalence of problem drinking (CAGE ≥ 2) remained steady in both men (20.7% [T2] and 20.4% [T3]; P = 0.18) and women (10.5% [T2] and 10.5% [T3]; P = 0.91). CONCLUSION: Our results suggest that long-term interventions focused on post-traumatic stress as well as other mental health problems are strongly needed for disaster-affected individuals.

Comprehensive Health Risk Management after the Fukushima Nuclear Power Plant Accident
S. Yamashita; Radiation Medical Science Center for the Fukushima Health Management Survey; Hitoshi Ohto; Masafumi Abe; Koichi Tanigawa; Kenji Kamiya; Seiji Yasumura; Mitsuaki Hosoya; Shinichi Suzuki; Akira Ohtsuru; Akira Sakai; Hiroaki Yabe; Masaharu Maeda; Keisei Fujimori; Tetsuo Ishikawa; Tetsuya Ohira; Tsuyoshi Watanabe; Hiroaki Satoh; Satoru Suzuki; Toshihiko Fukushima; Sanae Midorikawa; Hiromi Shimura; Takashi Matsuzuka; Hirofumi Mashiko; Aya Goto; Kenneth Nollet; Hideto Takahashi; Yoshisada Shibata; Makoto Miyazaki; Shiro Matsui; Seisho Tanaka
Clinical Oncology, 01 Apr. 2016, [Reviewed]

The Impact of Leisure and Social Activities on Activities of Daily Living of Middle-Aged Adults: Evidence from a National Longitudinal Survey in Japan.
Takafumi Monma; Fumi Takeda; Haruko Noguchi; Hideto Takahashi; Nanako Tamiya
PloS one, 2016, [Reviewed]
This study investigated the effects of leisure and social activities on the ability of middle-aged adults to maintain activities of daily living (ADL), and whether performing these activities alone or with others contributed to the ability to perform ADL. The study used nationally representative longitudinal data of 22,770 adults in Japan, aged 50-59 years, who did not have limitations in performing ADL at the beginning of the 5-year survey period. The study considered six activity categories: two leisure activities ("hobbies or cultural activities" and "exercise or sports") and four social activities ("community events," "support for children," "support for elderly individuals," and "other social activities"). Multiple logistic regression analysis was used to examine the relation between participation in these categories at baseline and difficulties in ADL at the 5-year follow-up. The association between the extent of social interaction during these activities ("by oneself," "with others," or "both") and difficulties in ADL was also investigated. The analysis yielded significant negative correlations between "exercise or sports" and difficulties in ADL for both men and women, and between "hobbies or cultural activities" and difficulties in ADL for women. However, these significant relationships occurred only when activities were conducted "with others." The present findings might help prevent deterioration in middle-aged adults' performance of ADL in Japan.

[Association between evacuation condition and habitual physical activity in Great East Japan Earthquake evacuees: The Fukushima Health Management Survey].
Nagai M; Ohira T; Yasumura S; Takahashi H; Yuki M; Nakano H; Wen Z; Yabe H; Ohtsuru A; Maeda M; Takase K; Fukushima health Management; Survey Group
[Nihon koshu eisei zasshi] Japanese journal of public health, 2016, [Reviewed]
Objectives Prevalence of life-style disease has increased dramatically in evacuees due to the Great East Japan Earthquake. One reason may be that physical activity level decreased from life environment changes due to evacuation. However, associations between evacuation condition and habitual physical activity have not been studied. We examined this association in Fukushima residents who participated in the Fukushima Health Management Survey.
Methods In this study, 37,843 evacuees from 13 municipal evacuation zones from the nuclear-power accident caused by the Great East Japan Earthquake, born before April 1, 1995, were included in the analysis. Evacuation condition was defined by disaster living place (13 zones), evacuation place (inside or outside the prefecture), and current living status (evacuation shelter or temporary housing, rental housing/ apartment, and relative's home or own home). Habitual physical activity was defined from self-administered questionnaires as participants who responded "almost every day" and "2-4 times/week" of regular exercise. In the analysis, habitual physical activity prevalence was aggregated by gender and variables (living place in the disaster, evacuation place, and current living status). Prevalence was adjusted for age, disaster living place, evacuation place, and current living status by standard analysis of covariance methods.
Results Adjusted prevalences of habitual physical activity were: men, 27.9-46.5%; women, 27.0-43.7% in each disaster living place. The differences were 18.6% point in men and 16.7% point in women. For evacuation place, physical activity outside the prefecture for men (37.7%) and inside the prefecture for women (32.1%) were higher, but those differences were only 2.2% point and 1.8% point in men and women, respectively. For current living status, physical activity of those in rental housing/ apartment was the lowest; evacuation shelter or temporary housing was the highest in both genders (men: 38.9%, women: 36.7%). Compared with residents in evacuation shelter or temporary housing, those in rental housing/apartment were 5.4% point and 7.1% point lower and those in relative's home or own home were 2.0% point and 4.2% point lower in men and women.
Conclusion Habitual physical activity in residents who lived in 13 municipal evacuation zone differed by disaster living place and current living status, while it was similar regardless of placement in the prefecture. In particular, prevalence was the lowest in participants who lived in rental housing/ apartment. We need to plan and perform additional life-style disease prevention strategies for participants who become isolated.

東日本大震災の避難者の避難状況と運動習慣 福島県「県民健康調査」　　　　　　　　　　　　　　　
Jan. 2016, [Reviewed]

小学生の心血管危険因子値の基準値に関する検討　　　　　　　　　　　　　　　
Sep. 2015

Influence of SLCO1B1 polymorphism on maintenance therapy for childhood leukemia
Ryoko Suzuki; Hiroko Fukushima; Emiko Noguchi; Masahiro Tsuchida; Nobutaka Kiyokawa; Kazutoshi Koike; Enbo Ma; Hideto Takahashi; Chie Kobayashi; Ryoko Nakajima-Yamaguchi; Aiko Sakai; Makoto Saito; Atsushi Iwabuchi; Keisuke Kato; Tomohei Nakao; Ai Yoshimi; Ryo Sumazaki; Takashi Fukushima
PEDIATRICS INTERNATIONAL, Aug. 2015, [Reviewed]

Association of Bystander Interventions With Neurologically Intact Survival Among Patients With Bystander-Witnessed Out-of-Hospital Cardiac Arrest in Japan.
Shinji Nakahara; Jun Tomio; Masao Ichikawa; Fumiaki Nakamura; Masamichi Nishida; Hideto Takahashi; Naoto Morimura; Tetsuya Sakamoto
JAMA, 21 Jul. 2015
IMPORTANCE: Neurologically intact survival after out-of-hospital cardiac arrest (OHCA) has been increasing in Japan. However, associations between increased prehospital care, including bystander interventions and increases in survival, have not been well estimated. OBJECTIVE: To estimate the associations between bystander interventions and changes in neurologically intact survival among patients with OHCA in Japan. DESIGN, SETTING, AND PARTICIPANTS: Retrospective descriptive study using data from Japan's nationwide OHCA registry, which started in January 2005. The registry includes all patients with OHCA transported to the hospital by emergency medical services (EMS) and recorded patients' characteristics, prehospital interventions, and outcomes. Participants were 167,912 patients with bystander-witnessed OHCA of presumed cardiac origin in the registry between January 2005 and December 2012. EXPOSURES: Prehospital interventions by bystander, including defibrillation using public-access automated external defibrillators and chest compression. MAIN OUTCOMES AND MEASURES: Neurologically intact survival was defined as Glasgow-Pittsburgh cerebral performance category score 1 or 2 and overall performance category scores 1 or 2 at 1 month or at discharge. The association between the interventions and neurologically intact survival was evaluated. RESULTS: From 2005 to 2012, the number of bystander-witnessed OHCAs of presumed cardiac origin increased from 17,882 (14.0 per 100,000 persons [95% CI, 13.8-14.2]) to 23,797 (18.7 per 100,000 persons [95% CI, 18.4-18.9]), and neurologically intact survival increased from 587 cases (age-adjusted proportion, 3.3% [95% CI, 3.0%-3.5%]) to 1710 cases (8.2% [95% CI, 7.8%-8.6%]). The rates of bystander chest compression increased from 38.6% to 50.9%, bystander-only defibrillation increased from 0.1% to 2.3%, bystander defibrillation combined with EMS defibrillation increased from 0.1% to 1.4%, and EMS-only defibrillation decreased from 26.6% to 23.5%. Performance of bystander chest compression, compared with no bystander chest compression, was associated with increased neurologically intact survival (8.4% [6594 survivors/78,592 cases] vs 4.1% [3595 survivors/88,720 cases]; odds ratio [OR], 1.52 [95% CI, 1.45-1.60]). Compared with EMS-only defibrillation (15.0% [6445 survivors/42,916 cases]), bystander-only defibrillation (40.7% [931 survivors/2287 cases]) was associated with increased neurologically intact survival (OR, 2.24 [95% CI, 1.93-2.61]), as was combined bystander and EMS defibrillation (30.5% [444 survivors/1456 cases]; OR, 1.50 [95% CI, 1.31-1.71]), whereas no defibrillation (2.0% [2369 survivors/120,653 cases]) was associated with reduced survival (OR, 0.43 [95% CI, 0.39-0.48]). CONCLUSIONS AND RELEVANCE: In Japan, between 2005 and 2012, the rates of bystander chest compression and bystander defibrillation increased and were associated with increased odds of neurologically intact survival.

Demographic and Socioeconomic Disparity in Knowledge About Tuberculosis in Inner Mongolia, China
Enbo Ma; Liping Ren; Wensheng Wang; Hideto Takahashi; Yukiko Wagatsuma; Yulin Ren; Fei Gao; Fangfang Gao; Wenrui Wang; Lifu Bi
JOURNAL OF EPIDEMIOLOGY, 24 Mar. 2015
Background: The aim of this study is to evaluate the awareness status, attitudes, and care-seeking behaviors concerning tuberculosis (TB) and associated factors among the public in Inner Mongolia, China.
Methods: A five-stage sampling was conducted, in which counties as the primary survey units and towns, villages, and households as sub-survey units were selected progressively. A standardized questionnaire was used to collect TB information. Complex survey analysis methods, including the procedures of survey frequency and survey logistic regression, were applied for analysis of TB knowledge and associated factors. The sample was weighted by survey design, non-respondent, and post-stratification adjustment.
Results: Among 10 581 respondents, awareness that TB is an infectious disease was 86.7%. Knowing that a cough lasting >= 3 weeks is suggestive of TB was 26.9%. Knowledge about TB dispensaries in county administrative areas was reported by 68.3% of respondents, and knowledge about the free TB detection/treatment policy was reported by 57.5% of respondents. About 52.5% of participants would stigmatize TB patients. Compared with the majority Han ethnic group, Mongolians and other minorities were 1.52-2.18 times more likely to know about TB curability, TB symptoms, the free detection/ treatment policy, and TB dispensaries' locations, but were less likely to know about the TB transmission mode (odds ratio, 0.74; 95% confidence interval, 0.65-0.84). The main sources of TB information were TV (65.6%) and other persons (47.2%). In the past year, 19.7% of TB knowledge was from acquaintances, and 16.1% was from TB institutes.
Conclusions: Improvement in knowledge about TB risk (symptoms and transmission), the free treatment policy, and facilities is necessary and should be provided through effective multimedia for different target populations.

The impact of transportation alternatives on the decision to cease driving by older adults in Japan.
Masao Ichikawa; Shinji Nakahara; Hideto Takahashi
Transportation, 2015

Health Disparities in Ischaemic Heart Disease Mortality in Hungary From 1970 to 2010: An Age-Period-Cohort Analysis
Krisztina Gero; Ehab S. Eshak; Enbo Ma; Hideto Takahashi; Hiroyuki Noda; Hiroyasu Iso
JOURNAL OF EPIDEMIOLOGY, 2015
Background: The objective of this study was to examine long-term trends in rates of ischaemic heart disease (IHD) mortality, a leading cause of mortality in Hungary. The study examined the effects of age, period, and cohort on IHD mortality rates and compared mortality rates between the capital (Budapest) and non-capital counties.
Methods: Data on IHD deaths and population censuses were obtained from the Hungarian Central Statistical Office. Age-period-cohort analysis utilized nine age-group classes for ages 40 to 84 years, eight time periods from 1970 to 2009, and 16 birth cohorts from 1886 to 1969.
Results: Age-adjusted IHD mortality rates for men and for women generally increased from 1970 to 1993 and from 1980 to 1999, respectively, decreasing thereafter for both sexes. IHD mortality rates for men and for women from Budapest were lower from 1991 and from 1970, respectively, than corresponding rates in non-capital counties, with the difference increasing after 1999. Age had a more significant influence on mortality rates for women than for men. The period effect increased from 1972 to 1982 and decreased thereafter for men, while the period effect decreased consistently for women from 1972 to 2007. The decline in period effect for both sexes was larger for individuals from the capital than for those from non-capital counties. The cohort effect for both sexes declined from birth years 1890 to 1965, with a steeper decline for individuals from the capital than for those from non-capital counties.
Conclusions: The findings indicate a need for programs in Hungary for IHD prevention, especially for non-capital counties.

Descriptive analysis of service use covered by long-term care insurance in Japan - based on population-based claims data
Nanako Tamiya; Masayo Kashiwagi; Hideto Takahashi; Haruko Noguchi
BMC Health Services Research, Jul. 2014, [Reviewed]

尿路上皮癌における全身化学療法前腎機能評価と効果に関する多施設観察研究　　　　　　　　　　　　　　　
Jun. 2014

Plasma free metanephrines in the diagnosis of pheochromocytoma: diagnostic accuracy and strategies for Japanese patients
Yuko Tanaka; Kazumasa Isobe; Enbo Ma; Tsuneo Imai; Toyone Kikumori; Tadashi Matsuda; Yuji Maeda; Akihiro Sakurai; Sanae Midorikawa; Yuji Hatayam; Taiya Kato; Kei Kamide; Yukihiro Ikeda; Yosuke Okada; Masahiro Adachi; Toshihiko Yanase; Hideto Takahashi; Chie Yokoyama; Yusuke Arai; Koichi Hashimoto; Hitoshi Shimano; Hisato Hara; Yasushi Kawakami; Kazuhiro Takekoshi
ENDOCRINE JOURNAL, 30 May 2014
Measuring the levels of the plasma free metanepbrines (PFMs) represents a recently developed and promising test for the diagnosis of pheochromocytoma in the United States and Europe. As this test has not yet been evaluated in Japan, it is necessary to evaluate the diagnostic efficacy of measuring the levels of PFMs compared with the standard measurement of the urinary excretion of metanephrines (uMNS) whose reliability is well established to detect of pheochromocytoma. A total of 101 Japanese subjects clinically suspected of having pheochromocytoma in were included in this study. Subsequently, we prospectively measured the PFMs levels in all patients, compared with those of biochemical markers of the catecholamine secretion and metabolisms in the plasma and urine. All subjects with adrenal tumors underwent tumor excision. Data were available for 84 of the 101 patients, 47 of whom had histopathologically proven pheochromocytoma and 37 were finally diagnosed with non-pheochromocytoma. The results of comparisons in the accuracy of measurement for diagnosis of pheochromocytoma between PFMs and the urinary excretion of metanepbrines (uMNs) were 0.980 VS 0.951 for AUC of receiver operatorating characteristic (ROC) curve, 0.957 VS 0.894 for sensitivity, and 0.973 VS 0.946 for specificity, respectively. Although the differences were small, the results of our study definitely demonstrated that measurement of PFMs was not inferior to standard urinary metanephrines (uMNS) measurement, which is established to be the most reliable biochemical method to detect pheochromocytoma. This study clearly shows measuring the PFMs levels to be a reliable and efficient method for diagnosing pheochromocytoma in Japanese patients, as demonstrated in previous reports.

かかりつけ医と腎臓専門医の連携の実際とCKD進展との関連について
斎藤 知栄; 甲斐 平康; 大久保 麗子; 岡田 昌史; 高橋 秀人; 土井 麻里子; 成田 一衛; 渡辺 毅; 菱田 明; 槇野 博史; 松尾 清一; 山縣,邦弘
日本腎臓学会誌, May 2014

腎疾患重症化予防のための戦略研究（FROM-J）参加患者の地域特性に関する検討
甲斐 平康; 斉藤 知栄; 大久保 麗子; 高橋 秀人; 岡田 昌史; 土井 麻理子; 成田 一衛; 渡辺 毅; 菱田 明; 槇野 博史; 松尾 清一; 山縣,邦弘
日本腎臓学会誌, May 2014

Regional difference in cancer detection rate in prostate cancer screening by a local municipality in Japan.　　　　　　　　　　　　　　　
KOISUMI\, Chie; SUETOMI\, Takahiro; MATSUOKA\, Taeko; IKEDA\, Atsushi; KIMURA\, Tomokazu; ONOZAWA\, Mizuki; MIYAZAKI\, Jun; KAWAI\, Koji; TAKAHASHI\, Hideto; AKAZA\, Hideyuki; NISHIYAMA\, Hiroyuki
Prostate International, 2014

Effect of Lifestyles of Children and Their Parents on the Levels of Cardiovascular Risk Factors in Elementary School Children　　　　　　　　　　　　　　　
Masao Yoshinaga; Ayumi Miyazaki; Machiko Aoki; Yoshiya Ito; Toshihide Kubo; Takashi Hamajima; Hitoshi Horigome; Hideto Takahashi; Mari Iwamoto; Hiromitus Ogata; Masakuni Tokuda; Tomoko Tachikawa; Nobuyuki Koriyama; Mitsuhiko Hara; Masaki Shinomiya; Masami Nagashima; Masami Nagashima
CIRCULATION, 2014, [Reviewed]

Myosin II ATPase activity mediates the long-term potentiation-induced exodus of stable F-actin bound by drebrin A from dendritic spines.
Toshiyuki Mizui; Yuko Sekino; Hiroyuki Yamazaki; Yuta Ishizuka; Hideto Takahashi; Nobuhiko Kojima; Masami Kojima; Tomoaki Shirao
PloS one, 2014
The neuronal actin-binding protein drebrin A forms a stable structure with F-actin in dendritic spines. NMDA receptor activation causes an exodus of F-actin bound by drebrin A (DA-actin) from dendritic spines, suggesting a pivotal role for DA-actin exodus in synaptic plasticity. We quantitatively assessed the extent of DA-actin localization to spines using the spine-dendrite ratio of drebrin A in cultured hippocampal neurons, and found that (1) chemical long-term potentiation (LTP) stimulation induces rapid DA-actin exodus and subsequent DA-actin re-entry in dendritic spines, (2) Ca(2+) influx through NMDA receptors regulates the exodus and the basal accumulation of DA-actin, and (3) the DA-actin exodus is blocked by myosin II ATPase inhibitor, but is not blocked by myosin light chain kinase (MLCK) or Rho-associated kinase (ROCK) inhibitors. These results indicate that myosin II mediates the interaction between NMDA receptor activation and DA-actin exodus in LTP induction. Furthermore, myosin II seems to be activated by a rapid actin-linked mechanism rather than slow MLC phosphorylation. Thus the myosin-II mediated DA-actin exodus might be an initial event in LTP induction, triggering actin polymerization and spine enlargement.

Descriptive analysis of service use covered by long-term care insurance in Japan - based on population-based claims data　　　　　　　　　　　　　　　
2014, [Reviewed]

Impact of cytokine expression in the pre-implanted donor lung on the development of chronic lung allograft dysfunction subtypes.
T Saito; H Takahashi; H Kaneda; M Binnie; S Azad; M Sato; T K Waddell; M Cypel; M Liu; S Keshavjee
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, Dec. 2013
The long-term success of lung transplantation continues to be challenged by the development of chronic lung allograft dysfunction (CLAD). The purpose of this study was to investigate the relationship between cytokine expression levels in pre-implanted donor lungs and the posttransplant development of CLAD and its subtypes, bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS). Of 109 patients who underwent bilateral lung or heart-lung transplantation and survived for more than 3 months, 50 BOS, 21 RAS and 38 patients with No CLAD were identified by pulmonary function test results. Using donor lung tissue biopsies sampled from each patient, expression levels of IL-6, IL-1β, IL-8, IL-10, interferon-γ and tumor necrosis factor-α mRNA were measured. IL-6 expression levels were significantly higher in pre-implanted lungs of patients that ultimately developed BOS compared to RAS and No CLAD (p = 0.025 and 0.011, respectively). Cox regression analysis demonstrated an association between high IL-6 expression levels and BOS development (hazard ratio = 4.98; 95% confidence interval = 2.42-10.2, p < 0.001). In conclusion, high IL-6 mRNA expression levels in pre-implanted donor lungs were associated with the development of BOS, not RAS. This association further supports the contention that early graft injury impacts on both late graft function and early graft function.

Evaluation of pre-hospital administration of adrenaline (epinephrine) by emergency medical services for patients with out of hospital cardiac arrest in Japan: controlled propensity matched retrospective cohort study
Shinji Nakahara; Jun Tomio; Hideto Takahashi; Masao Ichikawa; Masamichi Nishida; Naoto Morimura; Tetsuya Sakamoto
BMJ-BRITISH MEDICAL JOURNAL, Dec. 2013, [Reviewed]

Electrocardiographic Screening of 1-Month-Old Infants for Identifying Prolonged QT Intervals
Masao Yoshinaga; Hiroya Ushinohama; Seiichi Sato; Nobuo Tauchi; Hitoshi Horigome; Hideto Takahashi; Naokata Sumitomo; Yuu Kucho; Hirohiko Shiraishi; Yuichi Nomura; Wataru Shimizu; Masami Nagashima
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, 17 Sep. 2013, [Reviewed]
Background Neonatal electrocardiographic screening is used to screen infants with prolonged QT intervals, as previously shown in whites. However, this procedure needs to be confirmed in other ethnic groups.
Methods and Results In 8 areas in Japan, an ECG was recorded in 4285 infants at 1-month medical checkup. A prospective study showed that a provisional criterion of QTc 470 ms was appropriate for infants. To assess the validity of the criterion, all infants with a QTc between 460 and 470 ms were followed up. Five infants had a QTc 470 ms. Four infants were diagnosed with prolonged QT intervals from follow-up ECGs. Four infants showed no symptoms and did not have a family history of long-QT syndrome. Two infants showed progressive prolongation of QT intervals, and medication was started. Genetic testing was performed in 3 of 4 infants with prolonged QT intervals, and it revealed a KCNH2 mutation (3065 delT, L1021fs+34X) in 1 infant. One infant with a QTc 470 ms and 2 infants with a QTc between 460 and 470 ms showed a decline in their QTc values during follow-up. The study screened another infant with Wolff-Parkinson-White syndrome who was diagnosed with noncompaction before symptoms appeared.
Conclusions Neonatal electrocardiographic screening can identify infants likely to be affected by long-QT syndrome in the Japanese population, as already shown in whites. This screening may also be useful in identifying other important cardiac diseases.

Noninvasive visualization of endoleaks after endovascular aortic aneurysm repair through unenhanced MRI with motion-sensitized driven equilibrium preparation: Phantom experiments
Tsukasa Saida; Kensaku Mori; Hitoshi Yabe; Masashi Shindo; Katsuhiro Nasu; Masanari Shiigai; Hideto Takahashi; Manabu Minami
JOURNAL OF MAGNETIC RESONANCE IMAGING, 08 Jan. 2013, [Reviewed]
Purpose: To optimize imaging parameters for balanced turbo field echo (BTFE) sequence combined with motion-sensitized driven equilibrium (MSDE) preparation for endoleak detection and type classification in phantom experiments.
Materials and Methods: We prepared four phantoms: a pulsatile flow generator with an aortic aneurysm model simulating no endoleak, and a type-1, type-2, and type-3 endoleak. Throughout the experiments, MSDE-BTFE images with and without flow suppression were obtained at 1.5 T and subtraction images were used for image evaluation. The no-endoleak phantom was imaged using different MSDE-BTFE sequences to optimize the k-space trajectory and evaluate the use of electrocardiogram gating. The relative contrast between flowing saline and background was calculated. Then all phantoms were imaged to determine the optimal velocity encoding (VENC) for endoleak detection and type classification. Three independent observers performed the image evaluation. Consistencies between the interpreted and true results were analyzed using kappa statistics.
Results: The 3D low-high k-space trajectory with electrocardiogram gating provided the highest relative contrast. Low VENCs of 2-10 cm/s and high VENCs of 20 cm/s showed perfect consistency in endoleaks detection and type classification, respectively.
Conclusion: MSDE-BTFE sequences of appropriate VENCs has potential for endoleak detection and type classification, without contrast material. (c) 2013 Wiley Periodicals, Inc.

Polymorphisms of MTHFR Associated with Higher Relapse/Death Ratio and Delayed Weekly MTX Administration in Pediatric Lymphoid Malignancies.　　　　　　　　　　　　　　　
Hiroko Fukushima; Takashi Fukushima; Aiko Sakai; Ryoko Suzuki; Ryoko Nakajima-Yamaguchi; Chie Kobayashi; Atsushi Iwabuchi; Makoto Saito; Ai Yoshimi; Tomohei Nakano; Keisuke Kato; Masahiro Tsuchida; Hideto Takahashi; Kazutoshi Koike; Nobutaka Kiyokawa; Emiko Noguchi; Ryo Sumazaki
Leukemia Research and Treatment, 2013

Body Mass Index and Body Mass Index Z Score Trajectories from Birth to Adolescence　　　　　　　　　　　　　　　
Masao Yoshinaga; Yumiko Ninomiya; Yuji Tanaka; Kazuyuki Tanoue; Norihito Nuruki; Masahiro Sonoda; Hideto Takahashi; Masaki Shinomiya; Ayumi Miyazaki
CIRCULATION, 20 Nov. 2012, [Reviewed]

Inflammation-based prognostic score is a useful predictor of postoperative outcome in patients with extrahepatic cholangiocarcinoma
Yukio Oshiro; Ryoko Sasaki; Kiyoshi Fukunaga; Tadashi Kondo; Tatsuya Oda; Hideto Takahashi; Nobuhiro Ohkohchi
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES, 10 Nov. 2012
Recent studies have revealed that the Glasgow prognostic score (GPS), an inflammation-based prognostic score, is useful for predicting outcome in a variety of cancers. This study sought to investigate the significance of GPS for prognostication of patients who underwent surgery with extrahepatic cholangiocarcinoma.We retrospectively analyzed a total of 62 patients who underwent resection for extrahepatic cholangiocarcinoma. We calculated the GPS as follows: patients with both an elevated C-reactive protein (> 10 mg/L) and hypoalbuminemia (< 35 g/L) were allocated a score of 2; patients with one or none of these abnormalities were allocated a score of 1 or 0, respectively. Prognostic significance was analyzed by the log-rank test and a Cox proportional hazards model.Overall survival rate was 25.5 % at 5 years for all 62 patients. Venous invasion (p = 0.01), pathological primary tumor category (p = 0.013), lymph node metastasis category (p < 0.001), TNM stage (p < 0.001), and GPS (p = 0.008) were significantly associated with survival by univariate analysis. A Cox model demonstrated that increased GPS was an independent predictive factor with poor prognosis.The preoperative GPS is a useful predictor of postoperative outcome in patients with extrahepatic cholangiocarcinoma.

Dose-volume histogram analysis for risk factors of radiation-induced rib fracture after hypofractionated proton beam therapy for hepatocellular carcinoma
Ayae Kanemoto; Masashi Mizumoto; Toshiyuki Okumura; Hideto Takahashi; Takayuki Hashimoto; Yoshiko Oshiro; Nobuyoshi Fukumitsu; Takashi Moritake; Koji Tsuboi; Takeji Sakae; Hideyuki Sakurai
Acta Oncologica, 07 Sep. 2012

Application of conditional probability analysis to distant metastases from lung cancer
Akihiro Oikawa; Hideto Takahashi; Hiroichi Ishikawa; Koichi Kurishima; Katsunori Kagohashi; Hiroaki Satoh
ONCOLOGY LETTERS, 29 Jun. 2012
The aim of this study was to reveal whether there was non-randomness in the occurrence of metastasis and, if the non-randomness was denied, whether there were specific metastatic patterns in lung cancer patients. Patients who presented with pathologically diagnosed lung cancer between January 1986 and March 2009 at our hospitals were included. A statistical method and conditional probability analysis were used to analyze the data. Under the condition of one metastatic organ A (lung, bone, brain, liver or adrenal gland; the 5 most common metastatic organs), we determined the conditional probability of distant metastasis to a specific organ B, which was written as P(B vertical bar A), and compared it with the probability of distant metastasis P(B). The study group consisted of 1,994 patients. Of the 1,994 patients, 839 (42.1%) had distant metastases at the time of the initial diagnosis of lung cancer. With the exception of the comparisons between P(lung) and P(Iung vertical bar adrenal gland) and between P(adrenal gland) and P(adrenal gland vertical bar lung), there were statistically significant differences between P(B vertical bar A) and P(B) in the 5 metastatic organs. In addition, P(B vertical bar A) and P(C vertical bar B vertical bar A) varied according to each organ and P(confined to A), P(confined to A and B) and P(confined to A. B and C) were different in each metastatic organ. In lung cancer patients, distant metastasis occurred non-randomly and there may be certain specific patterns of distant metastasis. The accumulation of knowledge of specific patterns of metastasis may aid the approach to individualized treatments.

Long-term effect of overnight orthokeratology on axial length elongation in childhood myopia: a 5-year follow-up study.
Takahiro Hiraoka; Tetsuhiko Kakita; Fumiki Okamoto; Hideto Takahashi; Tetsuro Oshika
Investigative ophthalmology & visual science, 22 Jun. 2012
PURPOSE: Our prospective study was conducted to compare axial length elongation in myopic children receiving long-term overnight orthokeratology (OK) treatment to those wearing spectacles as controls. METHODS: There were 59 subjects enrolled in this study. The OK group comprised 29 subjects who matched the inclusion criteria for OK. The control group comprised 30 subjects who also matched the inclusion criteria for OK, but preferred spectacles for myopia correction. Axial length was measured periodically for 5 years using an IOLMaster device, and the time course of changes was evaluated and compared between the groups. RESULTS: A total of 43 subjects (22 and 21 in the OK and control groups, respectively) completed the 5-year follow-up examinations. At baseline, the mean age ± SD was 10.04 ± 1.43 and 9.95 ± 1.59 years, the spherical equivalent refractive error was -1.89 ± 0.82 and -1.83 ± 1.06 diopters (D), and the axial length was 24.09 ± 0.77 and 24.22 ± 0.71 mm in the OK and control groups, respectively, with no significant differences between the groups. The increase in axial length during the 5-year study period was 0.99 ± 0.47 and 1.41 ± 0.68 mm for the OK and control groups, respectively, and the difference was statistically significant (P = 0.0236, unpaired t-test). The annual increases in axial length were significantly different between the groups for the first (P = 0.0002), second (P = 0.0476), and third years (P = 0.0385), but not for the fourth (P = 0.0938) and fifth (P = 0.8633) years. There were no severe complications throughout the study period. CONCLUSIONS: The current 5-year follow-up study indicated that OK can suppress axial length elongation in childhood myopia.

Factors that prolong the 'postmortem interval until finding' (PMI-f) among community-dwelling elderly individuals in Japan: analysis of registration data
Tomoko Ito; Nanako Tamiya; Hideto Takahashi; Kentaro Yamazaki; Hideki Yamamoto; Shoji Sakano; Masayo Kashiwagi; Satoru Miyaishi
BMJ OPEN, 2012
Objectives: To clarify the factors affecting 'postmortem interval until finding' (PMI-f) among elderly unexpected death cases.
Design: Cross-sectional study.
Setting: All area of Yamagata prefecture in Japan.
Participants: Entering subjects were 5675 elderly cases with age of >= 65 years selected from all 9002 cases of unexpected death from 2002 to 2007 in Yamagata prefecture between 2002 and 2007. Our final study subjects consisted of 3387 cases sampled with several criteria to assess the factors to prolong PMI-f.
Primary outcome measures: The outcome was the postmortem interval until finding (PMI-f) as the time from death until finding the body which we defined in this study.
Results: 'Living alone' showed the highest adjusted HR (3.73, 95% CI 3.37 to 4.13), also 'unnatural death' (1.50, 1.28 to 1.75), 'found at own home' (1.37, 1.22 to 1.55) and 'younger subjects' (0.99, 0.98 to 0.99). In the model including interactions with the household situation, we found ` male subjects living alone' and ` female subjects living with family' tended to be found later.
Conclusions: PMI-f is an effective outcome for quantitative analyses of risk of bodies left. To prevent the elderly dead bodies left for long time, it is necessary to keep regular home-based contact with elderly individuals living alone.

Prospective intraindividual comparison of unenhanced magnetic resonance imaging vs contrast-enhanced computed tomography for the planning of endovascular abdominal aortic aneurysm repair
Tsukasa Saida; Kensaku Mori; Fujio Sato; Masashi Shindo; Hideto Takahashi; Nobuyuki Takahashi; Yuzuru Sakakibara; Manabu Minami
JOURNAL OF VASCULAR SURGERY, 23 Nov. 2011
Objective: This study clarified whether unenhanced magnetic resonance imaging (MRI) is an alternative to contrast-enhanced computed tomography (CT) for aortoiliac arterial measurement before endovascular abdominal aortic aneurysm repair (EVAR).
Methods: The institutional review board approved this prospective study. Twenty patients being considered for EVAR underwent MRI using a steady-state free-precession sequence in a 1.5-T system and contrast-enhanced CT within 4 weeks of each other. Two independent observers reviewed MRI and CT in random order using vessel analysis software and measured seven diameters, four lengths, and the angle of the aortoiliac arteries. The intermodality, interobserver, and intraobserver agreements were assessed for each measurement by intraclass correlation coefficients (ICCs) and the Altman-Bland method. Additionally, the observers independently recorded the number of bilateral renal arteries, decided EVAR suitability, and selected the main endograft on each modality.
Results: Intermodality ICCs for observers A and B showed ranges of 0.83 to 0.99 and 0.70 to 0.98; interobserver ICCs for MRI and CT showed ranges of 0.73 to 0.99 and 0.65 to 0.99; and intraobserver ICCs for MRI and CT showed ranges of 0.59 to 0.99 and 0.59 to 0.99. In intermodality, interobserver, and intraobserver comparisons, mean differences in diameters were included within the range -1 to +1 mm, excluding three of seven diameters on CT in interobserver comparison and one of seven on CT in intraobserver comparison. Mean differences in lengths were included within the range -5 to +5 mm, excluding one of four lengths in observer B in intermodality comparison and one of four on MRI and CT in interobserver comparison. All mean differences in angles were included within the range -5 degrees to +5 degrees. Both observers detected all 40 bilateral main renal arteries on MRI and CT. Of the 13 accessory renal arteries, observers A and B detected four (31%) and nine (69%), respectively, on MRI; in contrast, both observers detected 11 (85%) on CT. The observers independently determined that the same seven patients were suitable for EVAR on MRI and CT. Of the seven selected main endografts, seven and six diameters and five and six lengths agreed exactly between MRI and CT for observers A and B, respectively.
Conclusions: Although contrast-enhanced CT remains the gold standard for preoperative EVAR planning, unenhanced MRI with steady-state free-precession sequence can be an alternative modality for patients with contraindications for CT, such as renal impairment, because the intermodality agreement for preoperative measurements is as good as interobserver and intraobserver agreement. (J Vasc Surg 2012; 55: 679-87.)

Trends of stomach cancer mortality in Eastern Asia in 1950-2004: comparative study of Japan, Hong Kong and Singapore using age, period and cohort analysis
Masahiro Tanaka; Enbo Ma; Hideo Tanaka; Akiko Ioka; Toshitaka Nakahara; Hideto Takahashi
INTERNATIONAL JOURNAL OF CANCER, 17 Nov. 2011
To characterize the temporal trends of stomach cancer mortality in Eastern Asia and to better interpret the causes of the trends, we performed age, period and cohort analysis (APC analysis) on the mortality rates in Japan, Hong Kong and Singapore during 19502004, as well as the rates in the US as a control population. For the APC analysis, Holford's approach was used to avoid the identification problem. Age-standardized mortality rates (ASMR) decreased consistently in all four areas during the observation period in both males and females. Japan had the highest ASMR in both sexes, followed by Singapore, Hong Kong and the US, but the differences in ASMR among the four areas diminished with time. The results of APC analysis suggested that the decreasing mortality rates in Eastern Asia were caused by the combination of decreasing cohort effect since the end of the 1800s and decreasing period effect from the 1950s. The US showed similar results, but its decreases in the period and cohort effect preceded those of Eastern Asia. Possible causes for the decrease in the cohort effect include improvement in the socioeconomic conditions during childhood and a decrease in the prevalence of H. pylori infection, while possible causes for the decrease in the period effect include a decrease in dietary salt intake and improvements in cancer detection and treatment. These findings may help us to predict future changes in the mortality rates of stomach cancer.

Significant Associations Among Hemostatic Parameters, Adipokines, and Components of the Metabolic Syndrome in Japanese Preschool Children
Hitoshi Horigome; Yasutomi Katayama; Masao Yoshinaga; Yoshiaki Kato; Hideto Takahashi; Ryo Sumazaki
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, 28 Sep. 2011
Development of cardiovascular diseases could originate in early childhood. However, reference values of hemostatic parameters and adipokines in preschool children remain to be explored. We measured blood levels of adipokines and parameters of the hemostatic/fibrinolytic systems in 167 healthy children aged 4 to 6 years at 9: 00 to 10: 30 AM after a strictly enforced overnight fast. Participants with body mass index (BMI) values >= 90th percentile had significantly higher values of systolic blood pressure and heart rate, as well as blood levels of insulin, coagulation factor (F) VII, FX, protein S, leptin, and homeostasis model assessment of insulin resistance (HOMA-IR), and lower values of desacyl-ghrelin than children with BMI < 90th percentile. Circulating levels of fibrinogen and leptin increased with increased number of cardiovascular risk factors. Stepwise regression analysis identified many hematological variables to be associated with features of the metabolic syndrome. The results implicated the hemostatic/fibrinolytic system or adipokines in the insidious progression of cardiovascular diseases from an early age.

Prevalence of depression and depressive symptoms among older Japanese people: comorbidity of mild cognitive impairment and depression
Shin Hidaka; Chiaki Ikejima; Chiine Kodama; Mayumi Nose; Fumio Yamashita; Megumi Sasaki; Toru Kinoshita; Satoshi Tanimukai; Katsuyoshi Mizukami; Hideto Takahashi; Tatsuyuki Kakuma; Shiro Tanaka; Takashi Asada
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 31 Mar. 2011
Background: The aim of the study was to estimate the prevalence of DSM-III-R major depressive episodes (MDEs), depressive symptoms cases (DSCs) (defined as a score of >= 6 on the Geriatric Depression Scale but falling short of MDE), and coexisting mild cognitive impairment (MCI) among Japanese community-dwelling older people.
Methods: Prevalence was estimated based on screening evaluation, individual interviews, and doorto- door visits. MDE and DSC were diagnosed, and the cognitive status of the participants was determined to be dementia, MCI, or normal.
Results: A total of 1888 subjects of 2698 candidates (70.0%) participated. The prevalence of MDE and DSC were estimated to be 4.5% (95% CI, 3.4-6.0) and 11.5% (95% CI, 4.2-28.0), respectively. MCI was more prevalent in subjects with depression (26.2%) than those with normal mood (17.9%). Although no prototypical profile of cognitive dysfunction was revealed, multiple MCI was more prevalent in subjects with depression (12.2%) than subjects with normal mood (3.8%). Conversely, subjects with MCI (26.3%) were more likely to develop depression compared with those with normal cognitive function (18.0%).
Conclusions: The prevalence of depression in our subjects seems to be similar with that of previous studies. MCI was more prevalent in subjects with depression than those with normal mood. Individuals with depression showed no particular association with any of the four MCIs. Given that depression and MCI are often associated with each other and that MCI is a predictor for development of dementia, the risk of developing dementia in the depressed older people with coexisting MCI should be acknowledged. Copyright (C) 2011 John Wiley & Sons, Ltd.

Electrocardiographic Screening of One-Month-Old Infants for Long QT Syndrome in Japan
Yoshinaga Masao; Ushinohama Hiroya; Sato Seiichi; Tauchi Nobuo; Horigome Hitoshi; Takahashi Hideto; Shimizu Wataru; Sumitomo Naokata; Shiraishi Hirohiko; Nomura Yuichi; Nagashima Masami
J Arrhythmia, 2011
Introduction: Electrocardiographic and molecular studies have clarified an association between sudden infant death syndrome and long QT syndrome (LQTS). A prospective study to screen infants with LQTS was performed at one month medical check. Methods: Resting ECGs were recorded and the QT intervals of three consecutive beats were measured. A formula to minimize the effect of heart rate for infants was used: QTc=QT/RR^0.43. A provisional criterion of a QTc => 0.44^0.43 was used. To assess the validity of the criterion, all infants with a QTc => 0.43 were followed. Results: Of 4,319 infants who participated, six infants had a QTc value of => 0.44^0.43. From the follow-up ECGs, four infants were diagnosed as LQTS clinically. Two infants showed progress prolongation of the QT intervals; propranolol and mexiletine were administered when their QTc values exceeded => 0.50^0.43. Genetic testing revealed a KCNH2 mutation (3065 delT, L1021fs+34X) in one of these two infants. Ten infants with the QTc values between 0.43 and 0.44 showed decline in their QTc values during follow-up. The study screened another infant with left ventricular non-compaction with decreased ejection fraction. Conclusion: The incidence of LQTS infants who are clinically diagnosed may be close to 1:1,000. Electrocardiographic screening for infants will be successful to prevent deterioration of infants with risk.

Impact of Lifestyles of Adolescents and Their Parents on Cardiovascular Risk Factors in Adolescents
Masao Yoshinaga; Shinsaku Hatake; Tomoko Tachikawa; Masaki Shinomiya; Ayumi Miyazaki; Hideto Takahashi
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 2011
Aim: The aim of this study was to determine the impact of the lifestyles of adolescents and their parents on the levels of cardiovascular (CV) risk factors in the adolescents.
Methods: A total of 755 volunteers (331 male, 424 female) aged 15 to 18 years were included. Abdominal obesity, hypertension, elevated triglyceride levels, decreased high density lipoprotein-cholesterol levels, and hyperglycemia were considered to be CV risk factors. Self-reported lifestyle, including participation in school-based extracurricular (EC) physical activities, time spent on physical activity or watching television (TV), and average daily food intake were assessed. Parental information on weight status and lifestyle was also obtained.
Results: Multivariate regression analyses showed that participation in EC physical activities, time spent watching TV, regular breakfast consumption, total energy intake, fiber intake per 1,000 Kcal, and parental BMI were independently associated with the levels of one or more CV risk factors in adolescents. Among these, participation in EC physical activities had a profound effect on adolescent CV risk factor levels. The risk of male adolescent obesity was associated with paternal obesity, but not with maternal obesity. Conversely, the risk of female adolescent obesity was associated with maternal obesity but not with paternal obesity.
Conclusions: Participation in EC physical activities may be the first-line approach for adolescents to maintain favorable CV risk factor levels. An association between paternal or maternal obesity and adolescent obesity differs between adolescent genders in Japan; thus, approaches focusing on parents should take the gender of the adolescent into consideration.

The QT Intervals in Infancy and Time for Infantile ECG Screening for Long QT Syndrome
Masao Yoshinaga; Daisuke Hazeki; Yuji Tanaka; Akihiro Wada; Yoshiaki Kato; Hitoshi Horigome; Yuichi Nomura; Kentaro Ueno; Toshiaki Yasuda; Masami Nagashima; Kazuhiro Takahashi; Takashi Higaki; Hideto Takahashi; Hiroshi Suzuki; Masao Yoshinaga
Journal of Arrhythmia, 2011
Background: Electrocardiographic and molecular studies have clarified an association between sudden infant death syndrome (SIDS) and long QT syndrome (LQTS), and few data are available for the QT interval in infancy from birth to 1 year of age. Appropriate time of electrocardiographic screening is not clarified. Medical examinations during infancy are mandatory in Japan. Methods and Results: The study population included 1,058 infants. Electrocardiograms were collected with information of infants at birth and at examination. The QT intervals of three consecutive beats were measured in lead V5. Statistical analysis revealed that the following formula was appropriate to minimize the effect of heart rate for infants: corrected QT interval
QTc = QT interval/RR interval0.43. Subjects were divided into four groups as follows: 0-2, 3-6, 6-11, and 12-52 weeks of age. Tukey's multiple comparison showed that the QTc intervals were longest (p <
0.0001) in subjects who were 6-11 weeks of age. Conclusions: The QTc interval showed the highest peak at 6-11 weeks of age in infancy. The peak period of occurrence of SIDS is at approximately 2 months of age. An appropriate time of electrocardiographic screening for QT prolongation will be one month of age, and follow-up studies are needed. (J Arrhythmia 2011
27: 193-201). © 2011, Japanese Heart Rhythm Society. All rights reserved.

Optimal Cutoff Points of CYFRA21-1 for Survival Prediction in Non-small Cell Lung Cancer Patients Based on Running Statistical Analysis　　　　　　　　　　　　　　　
Hideto Takahashi; Koichi Kurishima; Hiroichi Ishikawa; Katsunori Kagohashi; Mio Kawaguchi; Hiroaki Satoh
ANTICANCER RESEARCH, 01 Sep. 2010, [Reviewed]
Purpose: To determine pretreatment serum CYFRA21-1 levels as indicators of poor prognosis in patients with non-small cell lung cancer (NSCLC). Methods: 1,202 consecutive patients, diagnosed pathologically with NSCLC from January 1999 to December 2009, were entered in this study. To obtain optimal cutoff points of CYFRA21-1 for these endpoints, a running log-rank statistical method was applied. Results: The cutoff level for the maximum log-rank statistical value of one-year survival in patients with NSCLC was 18.0 ng/ml. These results could be applied to patients with squamous cell carcinoma. In multivariate analysis, elevated (>18.0 ng/ml) levels of CYFRA21-1 was confirmed as being an unfavourable prognostic factor. Conclusion: CYFRA21-1 assay has a clinical significance for identifying patients with poor prognosis among those with early and advanced NSCLC. Elevated serum CYFRA21-1 levels at the time of diagnosis may be a useful noninvasive marker for identifying the risk of early death from NSCLC.

High-dose unfractionated heparin therapy in a pregnant patient with antiphospolipid syndrome: a case report
Hiroshi Ogishima; Satoshi Ito; Akito Tsutsumi; Makoto Sugihara; Daisuke Goto; Isao Matsumoto; Mana Obata-Yasuoka; Hiromi Hamada; Hiroyuki Yoshikawa; Hideto Takahashi; Atsuko Murashima; Takayuki Sumida
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, 14 Aug. 2010, [Reviewed]
A case of a 37-year-old pregnant patient with antiphospholipid syndrome (APS), who has a medical history of both thrombosis and recurrent fetal loss, is presented. She was treated with predonisolone and fixed-dose unfractionated heparin (UFH) infusion, followed by plasmaphereses and fixed-dose low-molecular-weight heparin infusion during her fourth pregnancy. Unfortunately, this treatment did not have beneficial effects, resulting in intrauterine growth restriction and finally neonatal death. Continuous intravenous UFH infusion and low-dose aspirin were administrated under the monitoring of the activated partial thromboplastin time to achieve a target level of 120 s during her fifth pregnancy. A healthy baby weighing 1818 g at birth was delivered by Cesarean section at the 34th week of pregnancy. High-dose UFH infusion may be considered to be one of the preferable options to manage pregnant patients with refractory APS.

Determinants of Blood Rheology in Healthy Adults and Children Using the Microchannel Array Flow Analyzer
Yasutomi Katayama; Hitoshi Horigome; Hideto Takahashi; Kiyoji Tanaka; Masao Yoshinaga
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, 10 Aug. 2010, [Reviewed]
Purpose: The reference values of blood rheology in healthy participants, especially children, are not available. The purpose of this study was to determine the blood passage time (BPT) as an index of blood rheology, in healthy children and adults, using the microchannel array flow analyzer, and to investigate the hematological factors that define BPT. Methods: Participants were 61 healthy children (35 boys, 26 girls; age 5-6 years) and 71 healthy adults (24 men, age 35.2 +/- 14.1 years; 47 women, age 44.7 +/- 14.1 years, mean +/- standard deviation [SD]). Blood passage time and various hematological variables (blood cell count, serum lipids, and fibrinogen) were measured and compared among the 4 study groups. Results: Blood passage time values were significantly higher in adult men (48.8 +/- 5.8 seconds) than in boys (41.9 +/- 4.0 seconds), girls (43.7 +/- 7.8 seconds), and adult women (42.4 +/- 4.8 seconds). Stepwise regression analysis identified erythrocyte count and hemoglobin (Hb) as the significant and independent determinants of BPT (P < .05). Conclusion: Our study demonstrates that BPT is significantly longer in healthy adult men than in adult women and children, and that erythrocyte count and Hb are significant determinants of blood rheology.

Measurement of health-related quality of life in patients with chronic kidney disease in Japan with EuroQol (EQ-5D)
Reiko Tajima; Masahide Kondo; Hirayasu Kai; Chie Saito; Masafumi Okada; Hideto Takahashi; Mariko Doi; Shuichi Tsuruoka; Kunihiro Yamagata
CLINICAL AND EXPERIMENTAL NEPHROLOGY, 23 Jun. 2010, [Reviewed]
Chronic kidney disease (CKD) is a health-related quality-of-life (HRQOL) deteriorating disease which is not only a public health but also a socioeconomic problem. Interest in developing cost-effective interventions to control CKD has increased. The aim of this study was to measure HRQOL in terms of quality-adjustment weights for cost-effectiveness analysis using EQ-5D in patients with CKD. The relationships between the measured HRQOL and clinical indices/complications were also analyzed.
EQ-5D, a generic preference-based instrument, was administered to 569 CKD outpatients at Tsukuba University Hospital between November and December 2008. The response rate was 94.4% (537/569). Data on sex, age, creatinine, hemoglobin, serum albumin and eGFR were obtained from the patients' records. Data on the presence of complications such as hypertension, diabetes, and history of cardiovascular disease (CVD) were also retrieved.
Measured quality-adjustment weights by the CKD stage were 0.940 (95% CI 0.915-0.965), 0.918 (0.896-0.940), 0.883 (0.857-0.909), 0.839 (0.794-0.884), and 0.798 (0.757-0.839) for stages 1-5, respectively. The decrease in weight was significant by ANOVA (P < 0.0001), and the weight for all stages was 0.885 (0.871-0.898). There was a positive relationship between hemoglobin/serum albumin and the weight. The presence of hypertension lowered the weight from 0.910 (0.885-0.936) to 0.874 (0.858-0.891), diabetes from 0.901 (0.886-0.917) to 0.840 (0.811-0.869), and CVD from 0.892 (0.878-0.906) to 0.783 (0.718-0.848).
HRQOL decreases with progression of CKD stage and/or presence of anemia, undernutrition, hypertension, diabetes, or history of CVD.

Cut-Offs for Screening Prolonged QT Intervals From Fridericia's Formula in Children and Adolescents
Daisuke Hazeki; Masao Yoshinaga; Hideto Takahashi; Yuji Tanaka; Yasue Haraguchi; Mayumi Abe; Masami Koga; Toshiro Fukushige; Masami Nagashima
CIRCULATION JOURNAL, 11 Jun. 2010, [Reviewed]
Background: The corrected QT interval (QTc) according to Bazett's formula (QTc=QT/RR(1/2)) has been used in clinical practice. Bazett's formula, however, overcorrects the QT interval at fast heart rates and undercorrects it at low heart rates. Guidelines and some investigators have recommended using Fridericia's formula (QTc= QT/RR(1/3)) in these cases, especially in tachycardic subjects. The aim of the present study was to determine cutoffs for QTc suitable for screening pediatric subjects with prolonged QT intervals, based on manually measured values corrected by Fridericia's formula in a large number of subjects.
Methods and Results: Three consecutive QT and RR intervals were measured in 4,655, 4,655, and 5,273 1st, 7th, and 10th graders, aged 6, 12, and 15 years, respectively. Each QT interval was corrected by Fridericia's formula, and mean values were calculated. Determination of the cut-offs for screening was based on the prevalence of abnormal electrocardiographic phenotypes of 1:1,164 and on the upper 0.025 percentile in the QTc distribution derived from previous studies. The tentative cut-offs suitable for screening subjects with prolonged QT intervals were 430 ms for 1st graders, 445ms for 7th graders, and 440 and 455 ms for 10th grade boys and girls, respectively.
Conclusions: These tentative cut-offs can be used to screen subjects with prolonged QT intervals in the clinical setting. Further studies are needed to confirm their validity. (Circ J 2010; 74: 1663-1669)

CKD患者におけるQOL(quality of life)評価と予後　　　　　　　　　　　　　　　
May 2010

Mothers and daughters-in-law: a prospective study of informal care-giving arrangements and survival in Japan
Akihiro Nishi; Nanako Tamiya; Masayo Kashiwagi; Hideto Takahashi; Mikiya Sato; Ichiro Kawachi
BMC GERIATRICS, 2010
Background: Daughters-in-law have played an important role in informal care-giving arrangements within East Asian traditional norms. The aim of this study was to measure the impact of daughter-in-law care-giving on the survival of care recipients. We prospectively examined the associations between different types of kinship relationship between the main family caregiver and the care recipient in relation to survival among care recipients.
Methods: A questionnaire was administered to Japanese community-dwelling seniors who were eligible to receive national long-term care insurance (LTCI) community-based services. Among 191 individuals whose informal caregiving arrangement was definitively determined, we observed 58 care recipients receiving care from spouses, 58 from daughters-in-law, 27 from biological daughters, 25 from other relatives, and 23 care recipients living alone.
Results: During 51 months of follow-up from December 2001, 68 care recipients died, 117 survived, and 6 moved. Hazard ratios of each care-giving arrangement were estimated by Cox proportional hazard models adjusted for care recipients' demographic factors, their care needs level based on their physical and cognitive functioning and their service use, caregivers' demographic factors, and household size. The highest risk of mortality was found for female elders receiving care from daughters-in-law (HR 4.15, 95% CI 1.02-16.90) followed by those receiving care from biological daughters (HR 1.64, 95% CI 0.37-7.21), compared to women receiving spousal care. By contrast, male elders receiving care from daughters-in-law tended to live longer than those receiving care from their spouses.
Conclusions: Our finding suggests that there may be a survival "penalty" for older Japanese women who are cared for by their daughters-in-law.

Visceral Fat Accumulation in Japanese High School Students and Related Atherosclerotic Risk Factors
Naoko Tadokoro; Masaki Shinomiya; Masao Yoshinaga; Hideto Takahashi; Kaori Matsuoka; Yo Miyashita; Masato Nakamura; Nobuichi Kuribayashi
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 2010
Aim: To investigate the factors that influence visceral fat accumulation in adolescence, we performed a medical examination of high school students and assessed abdominal fat thickness and fatty change of the liver.
Methods: A cohort of 374 Japanese high school students aged 15-16 years (193 boys and 181 girls) in public high schools in Chiba prefecture were enrolled. Anthropometric parameters, blood cell count, blood chemistry and adipocytokine levels were measured. Preperitoneal fat thickness (PFT) and echoic contrast of the liver were measured by ultrasonography.
Results: Anthropometric parameters, systolic blood pressure, blood cell count, ALT, AST, FBS,gamma-GTP, HDL-C, LpL, UA, adiponectin, resistin and leptin levels differed between sexes. Multivariate regression analysis revealed that leptin was the most appropriate marker for PFT in both sexes (p<0.0001). Visceral obesity, categorized as PFT exceeding 8 mm, was observed in 9.6% of all students. Boys with visceral obesity showed apparent liver dysfunction, hyperlipidemia, hyperinsulinemia, and high leptin and low adiponectin levels. Overall, 16.6% of boys and 30.4% of girls showed hepatorenal echo contrast positivity. Boys with visceral obesity and fatty liver had more risk factors for atherosclerosis.
Conclusions: Physical examination of high school students is important for early detection of atherosclerosis.

Impact of having One Cardiovascular Risk Factor on Other Cardiovascular Risk Factor Levels in Adolescents
Masao Yoshinaga; Hideto Takahashi; Masaki Shinomiya; Ayumi Miyazaki; Nobuichi Kuribayashi; Fukiko Ichida
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 2010
Aim: Little is known about the impact of having one cardiovascular (CV) risk factor on the levels of other CV risk factors in the general adolescent population. We hypothesized that when adolescents have one CV risk factor, the levels of other CV risk factors worsen simultaneously.
Methods: Subjects consisted of 1,257 healthy adolescent volunteers (549 males and 708 females) aged 15-18 years. Abdominal obesity, hypertension, raised triglyceride levels, decreased HDL-cholesterol levels and hyperglycemia were used as CV risk factors. Homeostasis assessment of insulin resistance (HOMA-IR) was used as a surrogate marker of insulin resistance. Levels of four biomarkers, leptin, adiponectin, high-sensitive C-reactive protein, and desacyl-ghrelin, were also determined. Cut-offs for gender-specific individual CV risk factor levels were based on the 90th (or 10th) percentile values of the subjects in the present study.
Results: The levels of all CV risk factors and HOMA-IR significantly and simultaneously worsened when adolescents had one CV risk factor in both genders. Having any one CV risk factor indicated the development of other CV risk factors in adolescents; in particular, we found that the development of abdominal obesity in male subjects had a harmful effect on the levels of other CV risk factors and was associated with the worsening of all four biomarkers examined.
Conclusions: It is important to determine the presence or absence of these CV risk factors before and/or during adolescence, because having one CV risk factor indicates the start of an accumulation of CV risk factors in the general adolescent population.

Clinical Characteristics and Genetic Background of Congenital Long-QT Syndrome Diagnosed in Fetal, Neonatal, and Infantile Life A Nationwide Questionnaire Survey in Japan
Hitoshi Horigome; Masami Nagashima; Naokata Sumitomo; Masao Yoshinaga; Hiroya Ushinohama; Mari Iwamoto; Junko Shiono; Koh Ichihashi; Satoshi Hasegawa; Tadahiro Yoshikawa; Tamotsu Matsunaga; Hiroko Goto; Kenji Waki; Masaki Arima; Hisashi Takasugi; Yasuhiko Tanaka; Nobuo Tauchi; Masanobu Ikoma; Noboru Inamura; Hideto Takahashi; Wataru Shimizu; Minoru Horie
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, 10 Dec. 2009
Background-Data on the clinical presentation and genotype-phenotype correlation of patients with congenital long-QT syndrome (LQTS) diagnosed at perinatal through infantile period are limited. A nationwide survey was conducted to characterize how LQTS detected during those periods is different from that in childhood or adolescence.
Methods and Results-Using questionnaires, 58 cases were registered from 33 institutions. Diagnosis (or suspicion) of LQTS was made during fetal life (n = 18), the neonatal period (n = 31, 18 of them at 0 to 2 days of life), and beyond the neonatal period (n = 9). Clinical presentation of LQTS included sinus bradycardia (n = 37), ventricular tachycardia/torsades de pointes (n = 27), atrioventricular block (n = 23), family history of LQTS (n = 21), sudden cardiac death/aborted cardiac arrest (n = 14), convulsion (n = 5), syncope (n = 5), and others. Genetic testing was available in 41 (71%) cases, and the genotype was confirmed in 29 (71%) cases, consisting of LQT1 (n = 11), LQT2 (n = 11), LQT3 (n = 6), and LQT8 (n = 1). Ventricular tachycardia/torsades de pointes and atrioventricular block were almost exclusively observed in patients with LQT2, LQT3, and LQT8, as well as in those with no known mutation. In LQT1 patients, clues to diagnosis were mostly sinus bradycardia or family history of LQTS. Sudden cardiac death/aborted cardiac arrest (n = 14) was noted in 4 cases with no known mutations as well as in 4 genotyped cases, although the remaining 6 did not undergo genotyping. Their subsequent clinical course after aborted cardiac arrest was favorable with administration of beta-blockers and mexiletine and with pacemaker implantation/implantable cardioverter-defibrillator.
Conclusions-Patients with LQTS who showed life-threatening arrhythmias at perinatal periods were mostly those with LQT2, LQT3, or no known mutations. Independent of the genotype, aggressive intervention resulted in effective suppression of arrhythmias, with only 7 deaths recorded. (Circ Arrhythm Electrophysiol. 2010; 3: 10-17.)

The social affecting factors to the postmortem interval: a study on the situations around death analyzed by Cox’s proportional hazard regression using the record of unexpected deaths for six years in Yamagata, Japan
Ito, T; Tamiya, N; Yamazaki, K; Takahashi, H; Matsuzawa, A; Yamamoto, H; Motozawa, M; Miyaishi, S
The 88th Jahrestagung der Deutschen Gesellschaft für Rechtsmedizin, Sep. 2009

Prevalence of childhood obesity from 1978 to 2007 in Japan
Masao Yoshinaga; Tomoko Ichiki; Yuji Tanaka; Daisuke Hazeki; Hitoshi Horigome; Hideto Takahashi; Katsuro Kashima
PEDIATRICS INTERNATIONAL, 25 Jul. 2009
Background:
There are few cross-sectional and longitudinal studies on identification of the age of onset of obesity. The purpose of the present study was therefore to investigate 30 years of cross-sectional and longitudinal changes in the prevalence of obesity from 1978 to 2007 in Japanese children and adolescents between 5 and 17 years of age, using population-based samples.
Methods:
Subject data were obtained from the Annual Reports of the School Health Survey published by the Ministry of Education, Culture, Sports, Science and Technology, Japan. Obesity was defined as a body mass index (BMI) at or above the 95th percentile for age and gender based on the reference years from 1979 to 1981 in Japan. The BMI was calculated as weight in kg/(height in m)2.
Results:
Cross-sectional analysis of 5-, 8-, 11-, 14-, and 17-year-olds showed that the prevalence of obesity has gradually decreased since the early 2000s, with the highest prevalence in the late 1990s to early 2000s, except for in 17 year-old boys. Longitudinal studies showed that the critical periods for developing obesity were in late infancy (between 5 and 6 years of age) and in the high school period in boys, and mainly in late infancy in girls.
Conclusions:
Intervention to prevent obesity should be focused on late infancy in both genders and male adolescents in Japan.

Patient Satisfaction and Clinical Outcomes After Overnight Orthokeratology
Takahiro Hiraoka; Chikako Okamoto; Yuko Ishii; Tetsuhiko Kakita; Fumiki Okamoto; Hideto Takahashi; Tetsuro Oshika
OPTOMETRY AND VISION SCIENCE, 23 Jun. 2009
Purpose. To assess patient satisfaction following overnight orthokeratology using a visual analogue scale and to find clinical factors that influence patient satisfaction.
Methods. In this prospective study, subjective patient satisfaction with visual outcomes was measured using a visual analogue scale, ranging from 0 (very dissatisfied) to 10 (very satisfied) in 17 patients who completed 1-year follow-up examinations after commencement of orthokeratology. Spherical equivalent refraction at baseline was 2.17 +/- 0.84 diopter (mean +/- SD). Various clinical parameters including refraction, visual acuity, ocular higher-order aberrations, and photopic and mesopic contrast sensitivity function were examined before and after the procedure. The influence of these parameters on patient satisfaction was evaluated using Spearman rank correlation test.
Results. The overall satisfaction with visual outcomes was scored 7.8 +/- 1.8 (range, 3.5 to 10). The level of satisfaction showed significant correlation (Spearman rank correlation coefficient; r = -0.599, p = 0.017) with posttreatment uncorrected visual acuity and pretreatment myopic error (r = 0.500, p = 0.045).
Conclusions. This Study demonstrated a relatively high level of patient satisfaction following overnight orthokeratology. Posttreatment uncorrected visual acuity is associated with patient satisfaction, and patients with higher myopia are predisposed to lower levels of subjective satisfaction. (Optom Vis Sci 2009;86:875-882)

CKD患者におけるEuroQol(EQ-5D)を用いたQOL(quality of life)の検討　　　　　　　　　　　　　　　
Apr. 2009

Simulation-based confidence interval of standardized mortality/morbidity ratio(SMR) when reference deaths/incidences have random variation.
Hideto Takahashi
Medicine and Biology, 2009

The Condition to Adopt the Assumption That Deaths in the Reference Cohort Have Random Variation in an Inference on Standard Mortality/Morbidity Ratio (SMR).
Hideto Takahashi
Medicine and Biology, 2009

Adiponectin and Adiponectin Receptors in Human Pheochromocytoma
Kazumasa Isobe; Ling Fu; Ichirou Tatsuno; Hideto Takahashi; Sumiko Nissato; Hisato Hara; Toru Yashiro; Kazumi Suzukawa; Kazuhiro Takekoshi; Hitoshi Shimano; Yasushi Kawakami
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 2009
Aim: Recent studies have demonstrated that serum adiponectin and its receptors in adipose and muscle tissues are suppressed in diabetic or obese individuals. Patients with pheochromocytoma are frequently diabetic.
Methods: Using real-time PCR, we examined mRNA expressions of adiponectin (Adp) and adiponectin receptor 1 (AdpR1) and AdpR2 in pheochromocytoma tissues from 49 patients. We also measured levels of serum total and high molecular weight (HMW) adiponectin levels in 10 pheochromocytomas and 33 normal volunteers.
Results: In pheochromocytoma tissue, AdpR1 mRNA expression was higher in adrenaline (A)-type tumors than in noradrenaline (NA)-type tumors. AdpR1 expression was significantly higher in A-type non-diabetics than in NA-type non-diabetics (p < 0.05). AdpR1 mRNA expression was significantly associated with the tumor tissue adrenaline content (P < 0.005) in linear regression analysis, which suggest that adrenaline positively regulates AdpR1 mRNA expression. Serum total and HMW Adp levels in patients with NA-type pheochromocytomas were approximately 3 times higher than those of healthy volunteers. After adrenalectomy, levels of adiponectin normalized.
Conclusion: Our results indicate that serum total and HMW Adp, and AdpR1 gene expressions in pheochromocytoma tissue, are associated with the level of catecholamine produced in the tumor. It is tempting to speculate that catechollamine induces adiponectin production and signaling.

Critical Period for Developing Obesity in Infants, Children, and Adolescents　　　　　　　　　　　　　　　
Masao Yoshinaga; Masaki Shinomiya; Ayumi Miyazaki; Etsuko Terahara; Hideto Takahashi; Daisuke Hazeki; Yuji Tanaka
OBESITY, 2009, [Reviewed]

Relationship between home care service use and changes in the care needs level of Japanese elderly
Gohei Kato; Nanako Tamiya; Masayo Kashiwagi; Mikiya Sato; Hideto Takahashi
BMC Geriatrics, 2009
Background. With the introduction of long-term care insurance (LTCI) in Japan, more home care services are available for the community-dwelling elderly. To deliver effective home care services, it is important to know the effects of service use. In this study, as the first step to determine this, we sought to describe different home service use in the sustained/improved group and deteriorated group in their care needs levels, and to report the relationship between the use of home care services and changes in care needs levels. Methods. The participants included 624 of a total of 1,474 users of LTCI services in one city in Japan. Home care service users were stratified into a 'lower care needs level subgroup' and a 'higher care needs level subgroup' based on the baseline care needs level. Simple statistical comparison and multiple logistic regression analyses in which the change in care needs level was set as a dependent variable were performed. Gender, age, and baseline care needs level were designated as control variables. Home based services were treated as independent variables. In this study, home care services consisted of home help, home bathing services, a visiting nurse, home rehabilitation, nursing home daycare, health daycare, loan of medical devices, respite stay in a nursing home, respite stay in a health care facility, respite stay in a sanatorium-type medical care facility, and medical management by a physician. Results. In the lower care needs level subgroup, age (OR = 1.04, CI, 1.01-1.08), use of respite stay in a nursing home (OR = 2.55
CI, 1.43-4.56), and the number of types of long-term care services (OR = 1.33
CI, 1.02-1.74) used during an 11 month period were significantly related to a deterioration of the user's care needs level. In the higher care needs level subgroup, use of medical management by a physician (OR = 6.99
CI, 1.42-41.25) was significantly related to a deterioration of the user's care needs level. There were no home based services significantly related to sustaining or improving the user's care needs level. Conclusion. There were different home service use in two groups (the sustained/improved group and the deteriorated group). Respite stay in a nursing home service use and more types of service use were related to experiencing a deterioration of care needs level in lower care needs level community-dwelling elderly persons in Japan. Further, medical management by a physician service was related to experiencing a deterioration of care needs level in higher care needs level community-dwelling elderly persons. © 2009 Kato et al
.

Association between the number of cardiovascular risk factors and each risk factor level in elementary school children
Masao Yoshinaga; Koji Sameshima; Yuji Tanaka; Michiko Arata; Akihiro Wada; Hideto Takahashi
CIRCULATION JOURNAL, 30 Aug. 2008, [Reviewed]
Background Little is known regarding the association between numbers of cardiovascular (CV) risk factors and the level of each risk factor in elementary school children based on a longitudinal study.
Methods and Results A descriptive Study Of 3 19 obese children aged 6-11 years who participated in a screening program for comorbidity of obesity between 2003 and 2005, and who participated in consecutive years thereafter, was performed. Abdominal obesity, hypertension, dyslipidemia (low high-density lipoprotein-cholesterol levels and/or high triglyceride levels), and raised fasting glucose levels were used as the CV risk factors. Metabolic syndrome and each CV risk factor were defined using the criteria newly established by a Task Force financed by the Health and Labour Science Research in Japan. An increase in the total number of CV risk factors implied a worsening of each CV risk factor level over a 1-year interval, and vice versa. Abdominal obesity in males and insulin resistance in females were prevalent in children who were at elementary school level.
Conclusions We should assess not only obesity but all CV risk factor levels, because a cluster of risk factors implies a worsening of the individual risk factor levels in children as young as those in elementary school.

在宅介護保険サービス利用者の介護度変化に関連する要因の検証
Apr. 2008

Reduction of human T-cell leukemia virus type-1 infection in mice lacking nuclear factor-kappa B-inducing kinase
Takayuki Nitta; Masakazu Tanaka; Binlian Sun; Eiji Sugihara; Mako Kimura; Yuhei Kamada; Hideto Takahashi; Shuji Hanai; Shi-Wen Jiang; Jun -ichi Fujisawa; Masanao Miwa
CANCER SCIENCE, 04 Mar. 2008
Human T-cell lymphotropic virus type 1 (HTLV-1) causes adult T-cell leukemia and inflammatory disorders. Aberrant activation of nuclear factor-kappa B (NF-kappa B) has been linked to HTLV-1 pathogenesis and to various kinds of cancers, including adult T-cell leukemia. NF-kappa B-inducing kinase (NIK) is critical for non-canonical activation of NF-kappa B and for the development of lymphoid organs. HTLV-1 activates NF-kappa B by the non-canonical pathway, but examination of the role of NIK in proliferation of HTLV-1-infected cells in vivo has been hindered by lack of a suitable animal model. Alymphoplasia (aly/aly) mice bear a mutation of NIK, resulting in defects in the development of lymphoid organs and severe deficiencies in both humoral and cell-mediated immunity. In the present study we therefore used a mouse model of HTLV-1 infection with aly/aly mice. The number of HTLV-1-infected cells in the reservoir organs in aly/aly mice was significantly smaller than in the control group 1 month after infection. In addition, aly/aly mice did not maintain provirus for 1 year and antibodies against HTLV-1 were undetectable. These results demonstrate that the absence of functional NIK impairs primary HTLV-1 proliferation and abolishes the maintenance of provirus. Interestingly, clonal proliferation of HTLV-1-infected mouse cells was not detected in aly/aly mice, which is consistent with the lack of HTLV-1 persistence. These observations imply that the clonal proliferation of HTLV-1-infected cells in secondary lymphoid organs might be important for HTLV-1 persistence.

Risk factors for in-hospital mortality during infective endocarditis in patients with congenital heart disease
Masao Yoshinaga; Koichiro Niwa; Atsuko Niwa; Naruhiko Ishiwada; Hideto Takahashi; Shigeyuki Echigo; Makoto Nakazawa
AMERICAN JOURNAL OF CARDIOLOGY, Jan. 2008
Despite developments in preventative and medical therapy, infective endocarditis (IE) carries a high rate of mortality. Risk factors for mortality are unknown in pediatric and adult patients with congenital heart disease (CHD). We determined the risk factors for in-hospital mortality in pediatric and adult patients with CHD. A retrospective observational cohort study was conducted from January 1997 to December 2001 in Japan. Of the 239 patients for whom complete data were available, 216 patients with CHD were identified. Outcomes were alive or deceased. The proposed modified Duke's criteria identified 137 patients, aged I month to 62 years with a median of 12 years, with IE. In-hospital mortality was 10%. Four risk factors were independently associated with mortality by stepwise logistic regression analysis: (1) vegetation size >= 20 mm (odds ratio 40.6, 95% confidence interval 2.42 to 68 1); (2) age < 1 year (odds ratio 19.5, 95% confidence interval 1.74 to 219); (3) presence of heart failure (odds ratio 7.16, 95% confidence ratio 1.34 to 38.4); and (4) Staphylococcus aureus as a causative organism (odds ratio 5.68, 95% confidence interval 1.16 to 27.9). Surgical intervention emerged as a predictive factor for lower in-hospital mortality (odds ratio 0.045, 95% confidence interval 0.003 to 0.70) by stepwise logistic regression analysis. In conclusion, surgical intervention, which decreases the risk of in-hospital mortality, should always be considered. (c) 2008 Elsevier Inc. All rights reserved.

Age-period-cohort analysis of mortality due to ischemic heart disease in Japan, 1955 to 2000
Enbo Ma; Hiroyasu Iso; Hideto Takahashi; Kazumasa Yamagishi; Takeshi Tanigawa
Circulation Journal, 2008
Background: Mortality from ischemic heart disease (IHD) has been showing a marked decline in Japan. The objective of this study was to clarify the effects of age, time period, and cohort on mortality from IHD in Japan from 1955 to 2000. Methods and Results: IHD death data from vital statistics and national population surveys were tabulated for 11 5-year age groups (from 30-34 to 80-84) and 10 quinquennial demographic profiles (from 1955 to 2000), to yield 20 5-year birth cohorts (mid-years from 1873 to 1968). The stratified Age-Period-Cohort model with 7 age classes shows: (1) mainly linear age trends for men with IHD, but effects below the linear age trends for women in middle-aged groups (40-74 years)
(2) a decline in the effect of time period on IHD for both men and women from 1970 to 1990, and a sharp increase between 1990 and 1995 along with the change of the International Classification of Diseases Code
and (3) 2 patterns for both sexes for non-linear birth cohort effects, an increase (1873-1928) and a decrease (1928-1968) for men, and an increase (1873-1923) and a decrease (1923-1968) for women, with a stronger effect for women than for men born between 1893 and 1938, but the reverse for men and women born between 1938 and 1968. Conclusion: Declining effects of birth cohort on mortality rates of IHD for young and middle-aged people suggest that mortality rates are likely to continue to decrease in Japan.

Stratified Age-Period-Cohort Analysis of Stroke Mortality in Japan, 1960 to 2000
Enbo Ma; Hideto Takahashi; Ayako Mizuno; Masafumi Okada; Kazumasa Yamagishi; Hiroyasu Iso
Journal of Stroke and Cerebrovascular Diseases, 11 Aug. 2007
Background: Although stroke mortality has been decreasing in Japan, in 2000 it was still the third leading cause of death among Japanese of either sex. Elucidation of stroke mortality trends among age, calendar year, and birth cohorts should improve stroke prevention efforts. The objective of this study was to clarify the age, period, and cohort effects on stroke mortality in Japan from 1960 to 2000 by using stratified age-period-cohort models with improved goodness of fit. Methods: Death and population from the Vital Statistics of Japan and the National Statistics Bureau, respectively, were tabulated among 12 age groups (30-34, 35-39, 40-44, 45-49, 50-54, 55-59, 60-64, 65-69, 70-74, 75-79, 80-84, and 85-89) and 9 quinquennials (1960, 1965, 1970, 1975, 1980, 1985, 1990, 1995, and 2000), which yielded 20 birth cohorts (midyears of 1873, 1878, 1883, 1888, 1893, 1898, 1903, 1908, 1913, 1918, 1923, 1928, 1933, 1938, 1943, 1948, 1953, 1958, 1963, and 1968). A stratified model (age-periods-cohort model) with 7 age classes (30-44, 45-54, 55-64, 65-69, 70-74, 75-79, and 80-89 years) was applied under the assumption that the number of deaths has an extra-Poisson variation. Results: The stratified model showed that: (1) middle-aged groups (40-64 years in men and 40-59 years in women) had higher mortality than their linear age trends
(2) young (30-44 years) and middle-aged (45-64 years) groups showed different patterns than those of the elderly (65-89 years) age groups: the two younger groups had higher nonlinear period effects than their linear trends between 1970 and 1990, and the trend of decreasing began later (in 1975 in men and 1980 in women, respectively) than it did for the elderly (1970)
and (3) the nonlinear cohort effects indicated 4 patterns in each sex, and the effects increased in post-1948 cohort in men and in post-1958 cohort in women. Conclusion: Young and middle age (30-59 years) boosted the mortality, suggesting that this age range should be targeted for increased stroke prevention efforts. © 2007 National Stroke Association.

The relationship in the P-value between Fisher exact Δ test and original Fisher exact test on Odds Ratio.　　　　　　　　　　　　　　　
Hideto Takahashi
Medicine and Biology, 2007

Risk factors for chronic kidney disease in a community-based population: a 10-year follow-up study
K. Yamagata; K. Ishida; T. Sairenchi; H. Takahashi; S. Ohba; T. Shiigai; M. Narita; A. Koyama
KIDNEY INTERNATIONAL, Jan. 2007
The purpose of this study was to explore risk factors affecting the incidence of chronic kidney disease (CKD) in general population. We conducted a 10-year follow-up study with 123 764 (male: 41 012, female: 82 752) adults aged 40 years and over who received community-based annual examinations. The primary outcome for the analysis was the development of CKD during the follow-up period. Predictors for the development of CKD were obtained by the significant hazard ratios (HR) in Cox regression model by sex. During the follow-up period, 4307 subjects (male: 2048, female: 2259) developed CKD stage I or II, and 19 411 subjects (male: 4257, female: 15 154) developed CKD stage III or higher. The baseline-adjusted predictor of developing CKD included age, glomerular filtration rate, hematuria, hypertension, diabetes, serum lipids, obesity, smoking status, and consumption of alcohol. Treated diabetes in male subjects, and treated hypertension, systolic blood pressure > 160 mm Hg and/or diastolic blood pressure > 100mm Hg, diabetes, and treated diabetes in female subjects were associated with more than a doubling of the HR. For the development of CKD stage III or higher, proteinuria of >=++, and proteinuria and hematuria were associated with more than a doubling of the HR in male subjects. The prevalence of newly developed CKD over 10 years was 23 718 subjects (19.2%) in adults. This study suggested that not only hypertension and diabetes but also several metabolic abnormalities were independent risk factors for developing CKD.

Breast disease: Clinical application of US elastography for diagnosis
A Itoh; E Ueno; E Tohno; H Kamma; H Takahashi; T Shiina; M Yamakawa; T Matsumura
RADIOLOGY, 18 Feb. 2006
Purpose: To evaluate the diagnostic performance of real-time freehand elastography by using the extended combined auto-correlation method (CAM) to differentiate benign from malignant breast lesions, with pathologic diagnosis as the reference standard.
Materials and Methods: This study was approved by the University of Tsukuba Human Subjects Institutional Review Board; all patients gave informed consent. Conventional ultrasonography (US) and real-time US elastography with CAM were performed in 111 women (mean age, 49.4 years; age range, 27-91 years) who had breast lesions (59 benign, 52 malignant). Elasticity images were assigned an elasticity score according to the degree and distribution of strain induced by light compression. The area under the curve and cutoff point, both of which were obtained by using a receiver operating characteristic curve analysis, were used to assess diagnostic performance. Mean scores were examined by using a Student t test. Sensitivity, specificity, and accuracy were compared by using the standard proportion difference test or the Delta-equivalent test.
Results: For elasticity score, the mean +/- standard deviation was 4.2 +/- 0.9 for malignant lesions and 2.1 +/- 1.0 for benign lesions (P < .001). When a cutoff point of between 3 and 4 was used, elastography had 86.5% sensitivity, 89.8% specificity, and 88.3% accuracy. When a best cutoff point of between 4 and 5 was used, conventional US had 71.2% sensitivity, 96.6% specificity, and 84.7% accuracy. Elastography had higher sensitivity than conventional US (P < .05). By using equivalence bands for noninferiority or equivalence, it was shown that the specificity of elastography was not inferior to that of conventional US and that the accuracy of elastography was equivalent to that of conventional US.
Conclusion: For assessing breast lesions, US elastography with the proposed imaging classification, which was simple compared with that of the Breast Imaging Recording and Data System classification, had almost the same diagnostic performance as conventional US.

Relationship between health behavoir and lifestyles/health status among Japanese adults
Mayumi Kishimoto; Hisako Fujita; Hideto Takahashi; Ichiro Okubo
Minzoku Eisei, Jpn J Health & Human Ecology, 2006
In recent years. Japanese adults have been consciously changing their core health behaviors.The purpose of this study is to clarify the relationship between the practice of health behaviorand lifestyle/health status. We conducted a questionnaire survey during August and Septemberin 2002 in 'A' city, Chiba. There were 464 valid responses (62.0%: 243 males, 261 females). 71.4% of subjects had a willing to do health behavior. Elderly females had the highest motivation to engage in health behavior. Among health behaviors, the use of dietary supplement was most popular (42.9%), especially females were more likely to use it than males (p<0.00l). The use of functional food was related to well-balanced meal (p<0.001), avoiding salty food (p=0.003), avoiding fat intake (p=0.019) and non-smoking (p=0.021). Those who practiced exercise activity had a tendency to ward better physical activities (p<0.001), intake of five or more vegetables in a day (p=0.042), well balanced meal (p=0.001), avoiding fat intake (p=0.031), and non-smoking (p=0.004). In contrast, us ers of energy drinks did not have preferable lifestyles. Regarding health status, outpatients had a strong tendency toward the lower use of dietary supplements (p=0.043), herbal medicine (p=0.027), and acupuncture (p=0.003). Other findings included significant relationships between high blood pressure and the use of herbal medicine (p=0.0l7), between back pain and massage/shiatsu (p=0.007), and between suffering allergies and using dietary supplement (p=0.003) and functional food (p<0.001). These finding may explain the relations of health behavior to both lifestyles and the health status.

わが国の急速進行性糸球体腎炎の治療におけるアフェレーシス療法の位置づけ　　　　　　　　　　　　　　　
山縣邦弘; 平山浩一; 高橋秀人; 小山哲夫
日本アフェレーシス学会雑誌, Jan. 2006

Apheresis for MPO-ANCA-associated RPGN-indications and efficacy: Lessons learned from Japan nationwide survey of RPGN
K Yamagata; K Hirayama; K Mase; N Yamaguchi; M Kobayashi; H Takahashi; A Koyama
JOURNAL OF CLINICAL APHERESIS, May 2005
A national survey concerning rapidly progressive glomerulonephritis (RPGN) was conducted in Japan between 1989 and 2000 and resulted in the registration of 715 patients with RPGN. Among the documented patients, the most frequent primary disease was primary pauci-immune crescentic glomerulonephritis (n = 283), and the second most frequent was microscopic polyangitis (n = 127). Overall, 370 patients had MPO-ANCA, and 23 patients had PR3-ANCA. We found that both renal and patient survivals were significantly worse in patients with MPO-ANCA-associated RPGN than patients with PR3-ANCA. Fifty-three patients received apheresis therapy with various combinations of immunosuppressive regimens. They had higher serum creatinine, higher CRP, and a higher frequency of complicated pulmonary involvements as compared to the controls without apheresis therapy. In dialysis-dependent patients, no additional benefit from apheresis therapy was observed. Only pulmonary renal syndrome patients with CRP > 6 mg/dl at presentation showed a slightly better prognosis (patient survival with apheresis; 66.7%, without apheresis; 56.7%). Furthermore, a rapid MPO-ANCA titer reduction was observed in patients treated with apheresis. Patients with MPO-ANCA-associated RPGN were older, and had more chronic and sclerotic lesions than patients with PR3-ANCA-associated RPGN. Based on these findings, we suggest that a lower dose of immunosuppressant should be considered in order to avoid opportunistic infection. In this situation, cytapheresis is the treatment of choice. Nevertheless, in patients with an aggressive form of RPGN with rapid deterioration of renal function like the PR3-ANCA-associatcd RPGN, or pulmonary renal syndrome complicated severe inflammation or relapses with high MPO-ANCA titer, we conclude that apheresis therapy should be considered.

Development of a tool for assessment of local government health policy
Toshimi Sairenchi; Hiroyasu Iso; Fujiko Irie; Kazumasa Yamagishi; Hideto Takahashi; Hiroyuki Noda; Nobuko Fukasawa; Hitoshi Ota; Tadao Nose
[Nippon kōshū eisei zasshi] Japanese journal of public health, 2005

非線形効果に基づく年齢-年次-出生コホート解析における効果の形状の表示について　　　　　　　　　　　　　　　
Oct. 2004

日本人肺炎、不慮の事故による死亡に関する年齢-年次-出生コホート解析、1960-2000　　　　　　　　　　　　　　　
Oct. 2004

Effect of relocating to areas of reduced atmospheric particulate matter levels on the human circulating leukocyte count
M Sakai; Y Sato; S Sato; S Ihara; M Onizuka; Y Sakakibara; H Takahashi
JOURNAL OF APPLIED PHYSIOLOGY, 06 Jul. 2004, [Reviewed]
A high level of atmospheric particulate matter induces an increase in circulating polymorphonuclear leukocyte (PMN) counts and an increase in serum inflammatory cytokine levels. The particulate level in Antarctica is extremely low compared with that in industrial countries. We hypothesized that this low level would reduce circulating leukocyte counts and serum inflammatory cytokine levels in people visiting Antarctica from industrial countries. The number density of particulates with aerodynamic diameters of <10.0 μm was measured in Japan and in Antarctica during the 41st Japanese Antarctic Research Expedition. Circulating leukocyte counts, granulocyte colony-stimulating factor and interleukin-6 levels, and pulmonary function were determined at regular intervals in 39 expedition members. The particulate number density was <1% of that measured in Japan. Total leukocytes, segmented and band-formed PMN, monocyte counts, and serum interleukin-6 levels decreased in Antarctica compared with the initial values measured in Japan. Pulmonary function parameters did not change except for maximal voluntary ventilation. Particulate matter levels had more significant effects on segmented PMN, band-formed PMN, and monocyte counts than cigarette smoking and the type of work. Exposure to reduced atmospheric particulates is considered to be a major factor for decreasing circulating leukocyte counts and serum cytokine levels.

Age distribution and yearly changes in the incidence of ESRD in Japan
K Yamagata; H Takahashi; S Suzuki; K Mase; M Hagiwara; Y Shimizu; K Hirayama; M Kobayashi; M Narita; A Koyama
AMERICAN JOURNAL OF KIDNEY DISEASES, 26 Feb. 2004
Background: Although several treatment and screening methods have been tried, the incidence of patients with end-stage renal disease (ESRD) on renal replacement therapy (RRT) continues to increase worldwide. By making a detailed analysis of the major primary renal diseases, we found there have been some favorable effects in the incidence rate of ESRD recently in Japan. Methods: A total of 339,478 patients in Japan and 909,591 patients in the United States started RRT between 1983 and 1999. We compared trends of average age and incidence rate in each age group with major primary renal diseases and in racial groups after adjusting for general population aging by using a linear regression analysis. Results: All trends in ESRD incidence rates among Japanese, US total, US white, and US black patients showed significant increases (P < 0.001). A significant positive linear relationship between year and mean age at start of RRT also was observed (P < 0.001). After adjustment for general population aging, the mean age increment in Japanese patients with glomerulonephritis was increased significantly, and the proportion of Japanese patients who had glomerulonephritis and were younger than 45 years was decreased, but this decrement was not observed in US patients with glomerulonephritis. Conclusion: The reduced number of new patients with ESRD with glomerulonephritis might be caused by early detection and early referral to nephrologists as a result of the Japanese urinalysis-screening program. To reduce the ESRD population, it will be necessary to establish more effective treatment methods to delay exacerbation of progressive renal diseases.

Naive (CD4+CD45RA+) T cell subpopulation is susceptible to various types of hazardous substances in the workplace.　　　　　　　　　　　　　　　
Tanigawa T; Takahashi H; Nakata A
Int J Immunopathol Pharmacol, 2004

Global Internet-Based Lifestyle Evaluation System(I-Livas) to Explore the Relationship between Lifestyles and Diseases
Hideto Takahashi; Masafumi Okada; Setsuko Kinoshita; Ayako Mizuno; Enbo MA
Medicine and Biology, 2004

Brain Death and Organ Transplantation: Knowledge, Attitudes and Practice among Japanese students　　　　　　　　　　　　　　　
Alireza Bagheri; Takamasa Tanaka; Hideto Takahashi; Shinichi Shoji
Eubios Journal of Asian and International Bioethics, 2003

Prognosis of asymptomatic hematuria and/or proteinuria in men - High prevalence of IgA nephropathy among proteinuric patients found in mass screening
K Yamagata; H Takahashi; C Tomida; Y Yamagata; A Koyama
NEPHRON, 22 May 2002
Aim: To elucidate prognosis and prevalence of chronic renal diseases among proteinuric and/or hematuric subjects found in mass screening, a long-term follow-up study (6.35 years, range 1.03-14.6 years) was conducted on Japanese working men. Methods: A total of 772 subjects selected from 50,501 Japanese men aged 15-62 years were found to have asymptomatic hematuria (n=404), concomitant hematuria and proteinuria (n=155), and proteinuria (n=213) during their annual urine examination and five consecutive urinalyses. Results: Hematuria patients showed significant improvements in urinary abnormalities as compared with both hematuria/proteinuria and proteinuria patients. Both hematuria/proteinuria patients with normotension and hematuria/proteinuria patients aged under 40 years showed significant improvements. During the follow-up period, 9.5% of the hematuria patients became hematuric/proteinuric. Hematuria/proteinuria patients had the highest risk of developing renal insufficiency. The presence of hypertension at detection of urinary abnormalities did not affect the renal function; however, if proteinuria appeared after the age of 40 years, these patients had a higher risk of developing renal insufficiency. The incidence of IgA nephropathy in the present subjects was as high as 143 cases per 1 million per year. Conclusion: Detailed follow-up and definitive diagnosis of asymptomatic urinary abnormalities may raise the prevalence of IgA nephropathy worldwide. Copyright (C) 2002 S. Karger AG, Basel.

Prognosis of asymptomatic hematuria and/or proteinuria in men. High prevalence of IgA nephropathy among proteinuric patients found in mass screening.
Kunihiro Yamagata; Hideto Takahashi; Chie Tomida; Yoh Yamagata; Akio Koyama
Nephron, May 2002
AIM: To elucidate prognosis and prevalence of chronic renal diseases among proteinuric and/or hematuric subjects found in mass screening, a long-term follow-up study (6.35 years, range 1.03-14.6 years) was conducted on Japanese working men. METHODS: A total of 772 subjects selected from 50,501 Japanese men aged 15-62 years were found to have asymptomatic hematuria (n = 404), concomitant hematuria and proteinuria (n = 155), and proteinuria (n = 213) during their annual urine examination and five consecutive urinalyses. RESULTS: Hematuria patients showed significant improvements in urinary abnormalities as compared with both hematuria/proteinuria and proteinuria patients. Both hematuria/proteinuria patients with normotension and hematuria/proteinuria patients aged under 40 years showed significant improvements. During the follow-up period, 9.5% of the hematuria patients became hematuric/proteinuric. Hematuria/proteinuria patients had the highest risk of developing renal insufficiency. The presence of hypertension at detection of urinary abnormalities did not affect the renal function; however, if proteinuria appeared after the age of 40 years, these patients had a higher risk of developing renal insufficiency. The incidence of IgA nephropathy in the present subjects was as high as 143 cases per 1 million per year. CONCLUSION: Detailed follow-up and definitive diagnosis of asymptomatic urinary abnormalities may raise the prevalence of IgA nephropathy worldwide.

[Comparison between HIV-1-infected hemophiliacs and non-hemophiliacs on survival and clinical courses after starting highly active antiretroviral therapy].
Misao Takano; Setsuko Kinoshita; Hideto Takahashi; Yukinao Kohda; Shinichi Oka
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, Mar. 2002
In order to investigate the long-term prognosis and clinical efficacy of highly active antiretroviral therapy (HAART) in HIV-1-infected hemophiliacs, we compared clinical courses of 69 HIV-1-infected hemophiliacs and 29 non-hemophiliacs all of whom were asymptomatic between 1990 and 1993. Changes of CD4 count during 1990 through 2000 in both groups were not significantly different. The time to death due to AIDS in both groups were also not significantly different. The major causes of death not related to AIDS in hemophiliacs were bleeding, liver cirrhosis, and liver cancer. A total of 55 (39 hemophiliacs and 16 non-hemophiliacs) out of 98 patients survived in 1997. Since then, the 28 hemophiliacs and the 12 non-hemophiliacs received HAART. Although the percentage of patients whose viral loads (VL) decreased to below undetectable level (VL < 400 copies/ml) by the initial HAART regimens without saquinavir were not significantly different, continuation of the same regimens in the hemophiliacs were significantly longer than non-hemophiliacs (84 weeks vs. 51 weeks, p < 0.05). From starting HAART to July 2000, 35.7% of the hemophiliacs were changed regimens three times or more. That is higher prevalence comparing with non-hemophiliacs of 16.7%. This study suggests that there might be the patient group who have to been changed HAART regimens frequently in the hemophiliacs.

Geographical pattern of malignant neoplasm by cluster analysis using standardized mortality ratios (SMRs) in Ibaraki Prefecture, Japan
Setsuko Kinoshita; Hideto Takahashi; Masafumi Okada; Hiroaki Nishikawa; Satoshi Toyokawa; Katsumi Kano
Journal of Epidemiology, 2002
We investigated the geographical patterns of mortality from eight (males)/ten (females) sites of malignant neoplasm, using cluster analysis with Standardized Mortality Ratios (SMRs), and examined the relationship between the mortality structure and urbanization. To explore the geographical tendencies is important for the prevention of cancers
such as noticing risk factors associated with regional variance. The death rates, by site, gender and age from 1990 to 1994 in Japan, were obtained from Vital Statistics. The deaths and population in municipalities were obtained from "Population of Ibaraki Prefecture". These were represented as averaged values in five-year periods. As an indicator of urbanization and mortality structure, the population density of municipalities and the overall rank scores of SMRs were used, respectively. Cluster analysis formed some distinctive structures. For males, Cluster 1 included four municipalities and three of these were located in the mountainous area in northwest Ibaraki, characterized by high SMRs from bone marrow. Cluster 5 consisted of the mid-south areas, characterized by high SMRs from stomach cancer. For females, the clusters seemed to be characterized by SMRs from esophagus cancer. An association between mortality structure and urbanization was found for females, 0.364(p<
0.01), but not for males, 0.162(p=0.14).

社会医学分野における質問紙調査のためのJavaクラスライブラリの構築　　　　　　　　　　　　　　　
Nov. 2001

Factors affecting renal function in 119,985 adults over three years　　　　　　　　　　　　　　　
K Ishida; H Ishida; M Narita; T Sairenchi; Y Saito; H Fukutomi; H Takahashi; K Yamagata; A Koyama
QJM-MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS, Oct. 2001, [Reviewed]
Blood pressure, proteinuria and serum creatinine (SCr) were examined in 119985 adults, aged 40 years and older, who attended annual health examinations both in 1993 and 3 years later. Renal function was assessed from SO; changes in individuals' renal function were estimated using the slope of the regression line for the reciprocal of the SCr level vs. time (slope of rSCr) over the 3-year period. Age-dependent SO concentration increments were observed; however, there was no significant age-dependent change in the slope of rSCr. SCr in hypertensives on anti-hypertensive medication was significantly higher than that in untreated hypertensives, borderline hypertensives and normotensives. The slopes of rSCr in hypertensives (treated, untreated and borderline) were steeper than normotensives in males, and that in untreated hypertensives was steeper than other groups in females. In hypertensives with proteinuria, SCr was higher and renal function deteriorated more rapidly, compared with hypertensives without proteinuria. Hypertension with proteinuria appears to be an important indicator for progressive decline in renal function, this trend being more obvious in males. Renal function decreases with age; however, the rate of decline is constant. The influences of proteinuria and blood pressure on renal function are different in males and females.

医学生の喫煙に関する意識と実態についての調査　　　　　　　　　　　　　　　
大塚盛男; 松井裕史; 久賀圭祐; 武田祐子; 佐藤浩昭; 高橋秀人; 関沢清久
CAMPUS HEALTH, Mar. 2001, [Reviewed]
将来患者に禁煙指導を効果的に行える医師を養成する為に必要な教育プログラムについて検討する為,医学生の喫煙の実態,喫煙に関する意識や知識について調査した.医学専門学群600名を対象に,国際結核肺疾患予防連合が作成した調査票に基づいて,自記式無記名アンケート調査を実施した.対照として,定期健康診断時の問診表から他学群生,大学院生,教職員の喫煙率を求め比較した.大学入学後に喫煙を開始する学生が多く,その喫煙習慣はその後も続く可能性が示唆された.大学生の喫煙を予防したり喫煙率を低下させるには入学後早期からの介入が重要であり,種々の喫煙制限対策も必要と考えられる.医学生の喫煙率を低下させ,禁煙指導トレーニング等の卒前臨床教育を充実させることは,患者教育の向上につながる可能性があると考えられる

Treatment strategy for patients with middle and lower third bile duct cancer
T. Todoroki; T. Kawamoto; N. Koike; K. Fukao; J. Shoda; H. Takahashi
British Journal of Surgery, 2001
Background: The prognosis for patients with middle and lower third bile duct carcinoma remains poor. This study was conducted to identify independent predictors for survival, as well as the patterns of recurrence after curative resection. Methods: Sixty-seven patients with pathologically verified middle and/or lower third bile duct carcinoma were analysed retrospectively by Cox regression analysis for predictors of survival. Results: The overall 5-year survival rate after resection was 39 per cent, and 0 per cent for patients who did not undergo resection. The 5-year survival rate was 63 per cent in 26 patients without microscopic residual disease (R0), 16 per cent in 25 patients with microscopic residual tumour (R1) and 0 per cent in six patients with macroscopic residual tumour (R2)
ten patients did not undergo resection. Radiotherapy improved the 5-year survival rate in eight patients who had R1 resection compared with the rate in 17 patients who underwent resection alone (8 versus 0), but not significantly so (P= 0.137)
however, median survival was significantly longer (P=0.004) in six patients who had R2 resection compared with that in ten inoperable patients (11.4 versus 3.5 months). Multivariate analysis revealed that the primary tumour and tumour node metastasis (TNM) stage were independent predictors of survival
13 clinicopathological factors were not independent prognostic factors. Of 26 patients having R0 resection, one had a locoregional relapse only, six had distant metastases only, and five had both types of recurrence. The liver was the most frequent site for metastasis, and microscopic venous invasion (MVI) in the primary tumour was a significant predictor of liver metastasis. Conclusion: Curative (R0) resection is only one step in curing cancer, and radiotherapy may play a beneficial role in controlling locoregional residual tumour. MVI could be a useful indicator of when systemic adjuvant therapy should be implemented to prevent liver metastasis after R0 resection, although no effective systemic treatment has yet been developed.

Assessment of smoking related risks for respiratory symptoms among elderly people
Kunio Ichimura; Hideto Takahashi; Masaru Ueji; Masafumi Okada; Takahiko Nishijima; Katsumi Kano
Environmental Health and Preventive Medicine, 2001
Disease risk among elderly smokers is considered to be doubled due to their smoking habits and age as compared with elderly non-smokers. The investigators conducted risk assessments of smoking for respiratory symptoms among elderly people. A questionnaire survey on smoking habits and respiratory symptoms was conducted among 3,000 persons of 56 years of age and over who were randomly selected from suburban residents in a prefecture in Japan in October, 1997. A total 1,954 or 65.1% of individuals responded, consisting of 42.8% for men and 57.2% for women, with an average age of 73.6 years. In addition to descriptive analysis, multiple logistic regression analysis was conducted. The results are summarized as follows: Smokers accounted for 28.1% of men and 3.6% of women. Among all age-groups, the highest rate of smokers was observed in men of 56-69 years old (34.7%) which was lower than the national average rate for the 60-69 year-old group (56.1% of men and 14.5% of women in '97). The odds ratios and 95 percent confidence interval (95%CI) for "having phlegm every day" and "having phlegm for more than 4 days a week" among smokers were 2.06 (95%CI=1.41-3.01) and 2.77(95%CI= 1.80-4.27). Significantly higher odds ratios among smokers were also observed for "wheezing" and "shortness of breath when hurrying". Odds ratios for some respiratory symptoms including "having phlegm for more than 4 days per week" among inhalers were significantly high compared with non-smokers, whereas those among non-inhalers were not significantly different from 1.0. Odds ratios for symptoms of phlegm and wheezing were significantly higher (Odds ratio ≥2.0) among heavy smokers (Brinkman Index [B. I.] >
900) compared to non-smokers, while odds ratios of the same symptoms were not different from 1.0 among light smokers (B. I. ≤500).

Age-period-cohort analysis of lung cancer mortality in Japan, 1960-1995
Hideto Takahashi; Masafumi Okada; Katsumi Kano
Journal of Epidemiology, 2001
The mortality data on lung cancer in Japan from 1960 to 1995 was analysed based on an ageperiod-cohort (APC) model. Though the APC model has an 'identifiable problem' caused by the relationship of age, period and cohort parameters, non-linear components of them revealed their original (separated) effects. They were: (1) non-linear age effects had a peak in 55-59 and 60-64 years old in males and 50-54 in females, (2) non-linear period effects were very small in both genders, (3) non-linear age and period effects were small enough to neglect compared with their linear effects, and (4) there were five parts of trends in Japanese lung cancer mortality in both genders in the non-linear birth cohort effects. The 1961-65 birth cohort effect seemed to increase differently from previous birth years. This trend should be monitored carefully.

A necessary and sufficient condition of comparability for using standardized mortality ratio (SMR)
Hideto Takahashi; Masafumi Okada; Lukman Thalib; Satoshi Toyokawa; Katsumi Kano
Journal of Epidemiology, 2001
A necessary and sufficient condition of comparability for using SMR was studied mathematically by considering the equivalence between SMR and CMF, as CMF was a perfectly comparable index. This condition was expressed by either proportionality of mortality vectors or proportionality of projected person-years to the plane spanned by mortality vectors of reference and index groups. We could obtain another expression of the condition, in which affect of distortions were easily understood, which consist of three factors: distortion of proportionality of mortality, distortion of person-years and similarity of distortions. Our results were applied to study the mortality of biliary tract cancer in Ibaraki Prefecture. Places where absolute difference between CMF and SMR exceeds some criterion (say, 0.15) were Satomi, Ushiboiri, Nihari in males and Gozenyama, Suifu and Asahi in females. All three distortion indices exceeded their upper 95% percentiles in Satomi in males. SMR, CMF, comparability, distortion of proportionality.

Radical resection of hilar bile duct carcinoma and predictors of survival
T Todoroki; T Kawamoto; N Koike; H Takahashi; S Yoshida; H Kashiwagi; Y Takada; M Otsuka; K Fukao
BRITISH JOURNAL OF SURGERY, 01 Mar. 2000
Background: Patients with carcinoma of the main hepatic duct have a poor prognosis. This study attempted to identify clinicopathological predictors of survival after resection.
Methods: A retrospective review was performed of 114 patients who presented with hepatic ductal carcinoma between 1976 and 1998. Of the 114 patients, 98 had a radical resection, three underwent palliative resection and 13 were not treated surgically. Forty-six patients with stage TVA disease had microscopic tumour residue after resection. Of these, 28 patients were treated with radiotherapy and the remaining 18 had resection alone.
Results: The overall operative morbidity and mortality rates were 14 and 4 per cent respectively. The overall 5-year survival rate after resection was 28 per cent. Nineteen patients survived lbr more than 5 years, including ten with stage IVA disease. The main prognostic factors were performance status; jaundice; tumour location; gross appearance; histological grade; T, N and M categories in tumour node metastasis (TNM) classification; TNM stage; and residual tumour. Adjuvant radiotherapy, tumour extension into the hepatic ducts, histological grade, N and residual tumour were independent predictive factors by multivariate Cox analysis.
Conclusion: This study suggests that radical resection provides the best survival rare for patients with hilar bile duct carcinoma. For patients with stage IVA disease, following complete gross resection radiotherapy improved treatment outcome.

RPGNの早期発見・早期治療に関する研究ー指針・治療法の試案ー
小山哲夫; 槇野博史; 二瓶宏; 有村義弘; 木田寛; 鈴木理志; 重松秀一; 山縣邦弘; 山口直人; 室かおり; 高橋秀人; 小林正貴
厚生省特定疾患進行性腎障害調査研究班平成11年度研究業績, Jan. 2000

茨城県の疾病分布のクラスター分析　　　　　　　　　　　　　　　
Oct. 1999

The protective effect of the sympathetic nervous system against acoustic trauma
Tetsuro Wada; Kazuhiko Takahashi; Zenya Ito; Akira Hara; Hideto Takahashi; Jun Kusakari
Auris Nasus Larynx, 01 Oct. 1999
Objective: the cochlea is innervated by the sympathetic nerve fibers. However, the functions of those fibers in the cochlea are still controversial. The present study was designed to determine whether the sympathetic nervous system (SNS) exerts a protective or enhancing effect on acoustic trauma. Methods: acoustic overstimulation (either of 110, 115, or 130 dB SPL for 10 min) was performed in guinea pigs during electrical stimulation of the ipsilateral cervical SNS, after its surgical elimination or in the non-treated condition. The threshold shift of the compound action potential (CAP) from the pre-exposure value was measured at 1 h and at 1 week after acoustic overstimulation. Two-way analyses of variance (ANOVAs) were completed for the SNS conditions and the frequencies. Results: although no significant difference was found at 1 h after overstimulation among these three groups, the CAP threshold shift at 1 week (110 and 115 dB SPL) was significantly smaller in the SNS stimulation group than in the other two groups. Conclusion: a protective effect was observed in the SNS stimulation group 1 week after the exposure to acoustic overstimulation of moderate intensity (from 110 to 115 dB SPL for 10 min). Copyright (C) 1999 Elsevier Science Ireland Ltd.

茨城県における乳癌死亡率の地域分布と経年変化　　　　　　　　　　　　　　　
Aug. 1999

Outcomes of aggressive treatment of stage IV gallbladder cancer and predictors of survival　　　　　　　　　　　　　　　
T Todoroki; H Takahashi; N Koike; T Kawamoto; T Kondo; S Yoshida; H Kashiwagi; M Otsuka; K Fukao; Y Saida
HEPATO-GASTROENTEROLOGY, 01 Jul. 1999
BACKGROUND/AIMS: Stage TV gallbladder carcinoma patients are rarely considered treatable by resection. They resign themselves to palliation because there is no long-term survival data available on the risks of morbidity and mortality following aggressive treatment. The aim of this study was to evaluate predictors of survival following aggressive resection surgery for stage IV gallbladder carcinoma.
METHODOLOGY: In this retrospective study, we examined 93 patients with stage IV gallbladder carcinoma who bad undergone resections. Of the 93 patients, 69 had undergone liver resection to various extents together with hepaticocholedochus resection (HCR); 2 had undergone pancreaticoduodenectomy (PD) both with and without HCR; 31 had undergone hepatopancreaticoduodenectomy (HPD); 7 had undergone cholecystectomy together with HCR; 12 had undergone cholecystectomy; and 3 had undergone extended cholecystectomy. Fifty of the 93 patients had also undergone adjuvant radiotherapy. Using univariate and multivariate analyses, 13 clinicopathologic risk factors were analyzed to predict; survival.
RESULTS: Operative morbidity and mortality rates were 17.2% and 5.4%, respectively. Overall, the 5-year survival rate and median survival time were 9.8% and 243 days, respectively. The 5-year survival rate was significantly higher in stage IVA (n=17) than in stage IVB (n=76), at 42.8% and 4.9%, respectively. Multivariate analysis revealed that sex, histopathologic type, lymph node involvement (N), subgroup of stage IV, post-resection residual tumors, and adjuvant radiotherapy were significant, predictors of survival.
CONCLUSIONS: Long-term survival, with acceptable mortality and morbidity, can be expected in female patients who have stage TVA gallbladder cancer consisting of well-differentiated adenocarcinoma and who undergo either complete microscopic resection or grossly complete resection followed by adjuvant radiotherapy.

Signal intensity changes in anterior cruciate ligament autografts: Relation to magnetic field orientation　　　　　　　　　　　　　　　
J Echigo; H Yoshioka; H Takahashi; M Niitsu; T Fukubayashi; Y Itai
ACADEMIC RADIOLOGY, 01 Apr. 1999
Rationale and Objectives. The purpose of this study was to use magnetic resonance (MR) imaging to investigate the contribution of graft alignment to changes in signal intensity in anterior cruciate ligament (ACL) autografts.
Materials and Methods. Forty patients who had undergone reconstruction of the ACL with an autograft underwent MR examinations of the knee in extension and flexion. The signal intensity of the intratibial bone tunnel and intraarticular portions of ACL graft were measured, acid signal intensity ratios were defined by dividing the mean signal intensity of the graft by the mean signal intensity of the fatty marrow. The angles from the intraarticular and intratibial bone tunnel portions of the graft to the static magnetic field were measured for each signal intensity ratio. The Hotteling T-2 test was used to evaluate the differences in signal intensity ratios to the differences in angles from flexion to extension for the intratibial bone tunnel and intraarticular portions of the graft.
Results, Significant increases occurred in the signal intensity of the graft and the angle with the change in position from flexion to extension for both the intratibial bone tunnel (P < .01) and intraarticular (P < .01) portions of the graft. Changes in signal intensity ratios were greater than zero, and these values differed significantly for the intraarticular and the intratibial bone tunnel (P < .01) portions of the graft.
Conclusion. The signal intensity changes of the ACL graft related to changes in its alignment are likely a result of the magic-angle effect.

Influence of grip strength on metacarpal bone mineral density in postmenopausal Japanese women: A cross-sectional study
D Osei-Hyiaman; M Ueji; S Toyokawa; H Takahashi; K Kano
CALCIFIED TISSUE INTERNATIONAL, 01 Mar. 1999
Most published studies on the role of muscle strength in the maintenance of bone mineral density (BMD) focused on the relationship between specific muscle groups and adjacent bones, mostly in young and premenopausal women. This study examined the influence of grip strength on BMD of the metacarpal index in postmenopausal Japanese women. Subjects included 1168 postmenopausal women aged 40-70 years. BMD measurement was done with computed X-ray densitometry (CXD) by analyzing Xray films of the right second metacarpal index. Grip strength was measured in both the dominant and nondominant hands using a squeeze dynamometer. Grip strength (r = 0.2474; P = 0.0001) and age (r = -0.5443; P = 0.0001) significantly correlated positively and negatively, respectively, with BMD. Physical activity (r = 0.1318; P = 0.0001) also correlated positively with BMD. Breastfeeding (r = -0.1658; P = 0.0001), however, correlated negatively with BMD. Subjects with a history of regular physical activity had higher grip strengths and BMD, than those with no physical activity. Adjustment for age, physical activity, calcium intake, BMI, breastfeeding, testing site, and menopausal type indicated a significant (P for trend = 0.0013) positive association of grip strength with BMD. Subjects with stronger grip strengths had a decreased risk for low BMD.

Treatment regimen adherence and life-satisfaction in hemodialysis patients: A covariance structure analysis
M. Oka; S. Tomura; H. Takahashi; S. Tsuchiya
Clinical and Experimental Nephrology, 1999
Background. The purpose of this study was to clarify the causal relationship among factors related to treatment regimen adherence and life- satisfaction in hemodialysis patients by a covariance structure analysis. Methods. Self- administered questionnaires were obtained from 209 patients. The variables were as follows (with η representing endogenous latent variables, ξ, exogenous latent variables
and x, observed variables): treatment regimen adherence (η 1), dietary management behavior (x 1)
life- satisfaction (η 2), life-satisfaction in hemodialysis patients (x 2)
self- determination (η 3), self-determination factor concerning self-care (x 3) and self-determination factor concerning patient-medical staff relationship (x 4)
self-efficacy (η 4), self-efficacy for dietary management (x 5)
emotional support from medical staff (ξ 1), emotional support from medical doctors (x 6), and emotional support from nurses (x 7). Results. Treatment regimen adherence was directly influenced by self-efficacy (β = 0.978
P <
0.05), and was indirectly influenced by emotional support from medical staff (γ = -0.266
P <
0.05) and self-determination (β = 0.101
P <
0.05). Life- satisfaction was directly influenced by emotional support from medical staff (γ = 0.412
P <
0.05) and self-determination (β = 0.337
P <
0.05), and was indirectly influenced by emotional support from medical staff (γ = -0.266
P <
0.05). The goodness-of-fit-index of this model was 0.93, and the adjusted goodness-of-fit-index was 0.84. Conclusions. (1) The only patient characteristic which had a significant relation with adherence was age over 65 years, and the characteristics which had a significant relation with life- satisfaction were those of living with family and having an occupation. (2) Good adherence regarding dietary behavior was directly influenced by the level of self-efficacy. Less emotional support from medical staff resulted in greater self-determination, leading to higher self-efficacy, which indirectly induced high adherence. (3) The degree of life-satisfaction was directly influenced by the level of emotional support from medical staff and by the degree of self-determination. Less emotional support from medical staff indirectly enhanced self-determination, leading to higher life-satisfaction.

Timing of menopause, reproductive years, and bone mineral density - A cross-sectional study of postmenopausal Japanese women　　　　　　　　　　　　　　　
D Osei-Hyiaman; T Satoshi; M Ueji; T Hideto; K Kano
AMERICAN JOURNAL OF EPIDEMIOLOGY, 01 Dec. 1998
Age at menopause has been found to be associated positively with bone mineral density, and age at menarche has been found to be associated negatively with bone mineral density. However, there have been few studies on the relations of timing of menopause and length of the reproductive period with bone mineral density. The purpose of this study was to examine the relations of timing of menopause and reproductive years (calculated as age at menopause minus age at menarche) with mineral density of the second metacarpal bone in postmenopausal Japanese women. The study population consisted of 1,035 naturally menopausal women aged 40-70 years who were screened in 1996-1997. Using computed x-ray densitometry, the authors measured bone mineral density by analyzing radiographic films of the right second metacarpal bone. Using the women with early menopause (age <49 years) as the reference group and adjusting for age, subjects with late menopause were at decreased risk for low bone mineral density (odds ratio (OR) = 0.69, 95% confidence interval (CI) 0.49-0.97). After adjustment for additional covariates (grip strength, physical activity, body mass index, smoking, and calcium intake), the association was unchanged (OR = 0.70, 95% CI 0.50-0.99). Postmenopausal women with more reproductive years (greater than or equal to 40 years) were at decreased risk for low bone mineral density compared with those with fewer reproductive years, after adjustment for age (OR = 0.73, 95% CI 0.40-1.30) and potentially confounding factors (OR = 0.76, 95% CI 0.41-1.37); the p-value for trend was not statistically significant. In multiple linear regression analysis, early menopause and fewer reproductive years were independent predictors of low bone mineral density. In this study, postmenopausal Japanese women who had a late menopause and more reproductive years were at decreased risk for low bone mineral density, and may therefore be less prone to osteoporosis.

インターネットによる生活習慣調査　　　　　　　　　　　　　　　
Oct. 1998

Risk factors for breast cancer among Japanese women: A case-control study in Ibaraki, Japan
Masaru Ueji; Ei Ueno; Douglas Osei-Hyiaman; Tomoko Saito; Hideto Takahashi; Katsumi Kano
Breast Cancer, 01 Oct. 1998
Background: The number of epidemiologic studies on breast cancer risk factors in Japanese women is still quite limited. Our objective was to clarify the relationship between lifestyle, body size and breast cancer risk. Methods: A matched case-control study was conducted in Ibaraki, Japan. The participants were 148 women aged 26-69 diagnosed with breast cancer at Tsukuba University Hospital or Tsukuba Medical Center Hospital between January, 1990 and March, 1997. Two controls were individually matched to the cases by age and residence. A self-administered questionnaire was used to obtain information on the family history of breast cancer, reproductive history, education, body size and lifestyle factors. Conditional logistic regression analysis was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CI). Results: After adjustment for potential confounders, heavy weight and higher body mass index were associated with an increased risk of breast cancer among postmenopausal women (OR = 1.76, 95% 0 = 0.69, 4.48
OR = 1.57, 95% Cl = 0.61, 3.99, respectively). Current or ex-smokers were found to be at an increased risk for breast cancer (OR = 3.33
95% Cl = l.63, 6.80). Women who take hot baths had a decreased risk for breast cancer (OR = 0.67
95% Cl = 0.43, 1.06). Recreational physical activity was associated with a reduced risk of breast cancer (P Trend = 0.005). OR for breast cancer among physically active women was 0.36 (95% Cl = 0.19, 0.70), as compared with inactive women. Taller women had an increased risk of breast cancer relative to shorter women (OR = 1.49
95% Cl = 0.83, 2.70). No significant association between alcohol consumption and breast cancer risk was detected. Conclusions: Our results suggest that several potentially modifiable lifestyle factors may be useful for the prevention of breast cancer.

Elevated serum sialyl Lewis X-i antigen levels in non-small cell lung cancer with lung metastasis　　　　　　　　　　　　　　　
H Satoh; H Ishikawa; H Kamma; YT Yamashita; H Takahashi; M Ohtsuka; S Hasegawa
RESPIRATION, 01 Jul. 1998
To evaluate the relationship between serum levels of sialyl Lewis X-i antigen and lung metastasis in patients with non-small cell lung cancer (NSCLC), we measured the serum level of the antigen in 299 patients with untreated locally advanced or metastatic NSCLC. Before treatment, serum levels of sialyl Lewis X-i antigen were significantly higher in patients with lung metastasis than in those without lung metastatis (p = 0.0001). Of 201 patients without lung metastasis at the time of primary diagnosis, 121 patients died between July 1987 and December 1995. Serum levels of sialyl Lewis X-i antigen in 21 patients who developed lung metastasis during the period were significantly higher than those in 100 patients who did not develop lung metastasis (p = 0.0171). Our results suggested that sialyl Lewis X-i antigen might be a good indicator for the presence or development of lung metastasis, and it might provide clinical information about the management of patients with NSCLC.

Analysis of long-term survivors after platinum containing chemotherapy in advanced non-small cell lung cancer　　　　　　　　　　　　　　　
H Satoh; H Ishikawa; YT Yamashita; T Naito; H Takahashi; H Kamma; M Ohtsuka; S Hasegawa
ANTICANCER RESEARCH, 01 Mar. 1998
Among 195 patients with locally advanced or metastatic non-small cell lung cancer(NSCLC), we evaluated the characteristics of two-year survivors. All the patients with stage IIIA-IV disease received platinum containing combination chemotherapy at Tsukuba University Hospital between 1985 and 1996. Fourteen patients (7.2%) and 7 patients (3.6%) survived for more than 2 and 3 years, respectively Ten of the 14 responded to initial chemotherapy, and 9 patients received additional treatment such as thoracic irradiation and/or surgical resection. Three of the 14 patients survived more than 5 years disease free, one of them survived more than 10 years. From the results uni-and multivariate analyses of these patients, early stage of the disease, low number of metastatic site, without associated lung disease were confirmed as significant determinants of survival This study revealed that a small proportion of patients with advanced NSCLC might be potentially curable with appropriate treatment.

Development of a system for lifestyle evaluation and health education support　　　　　　　　　　　　　　　
C. Sakuragi; T. Saito; F. Wang; H. Takahashi; K. Kano
Japan Journal of Medical Informatics, 1998

Physical Activity and the Risk of Breast Cancer: A Case-Control Study of Japanese Women　　　　　　　　　　　　　　　
M.Ueji; E.Ueno; D.O-Hyiaman; H.Takahashi; K.Kano
Journal of Epidemiology, 1998

Lifestyle evaluation system to support health education
C Sakuragi; T Saito; F Wang; H Takahashi; Y Sato; K Kikuchi; K Kano
MEDINFO '98 - 9TH WORLD CONGRESS ON MEDICAL INFORMATICS, PTS 1 AND 2, 1998
A computer-based system far evaluation of one's lifestyle was designed so that public health nurses could use it for health education to improve a patients lifestyle and to prevent lifestyle-related diseases. The Lifestyle Evaluation System (LES) is a computer program that works on a personal computer.
The LES is consist of four parfs; inputting personal data, answering the questionnaire, showing the result and getting health check up data The questionnaire includes 40 questions regarding diet, smoking, drinking, physical activity rest social activity and health care activities, based on Breslow's seven lifestyles. The result offers participants' lifestyle evaluation in forms of values, graphs, tables and messages. Evaluation values Me deviation value, rank BMI and standard weight. The LES also offers participant's periodic health check data, average data derived from all residentsi data, and past results of LES so that public health nurses are able to use these for health education
The health check data is obtained from another database stored on floppy disks.
The participants input data by themselves and get result immediately. The interactive style is effective in raising interest iii health education.

Pleural effusion as a significant prognostic factor in non-small cell lung cancer　　　　　　　　　　　　　　　
T Naito; H Satoh; H Ishikawa; YT Yamashita; H Kamma; H Takahashi; M Ohtsuka; S Hasegawa
ANTICANCER RESEARCH, 01 Nov. 1997
In non-small cell lung cancer (NSCLC), pleural effusion is a frequently observed complication, and often provides a treatment difficulties. The aim of this study is to evaluate prognostic significance of pleural effusion in patients with NSCLC. Materials and Methods: Seven hundred and eight untreated patients with NSCLC who were consecutively admitted to our department over a 20 year period up to December 1996, were analyzed using uni-and multivariate analyses. Results: Univariate analysis showed pleural effusion to be a significant prognostic factor for NSCLC, in addition to gender stage, performance status(PS). Multivariate analysis proved pleural effusion to be one of the significant prognostic factors, especially in patients with poor PS. Conclusion: Adequate palliative care to provide prolonged quality survival remains the primary goal of therapy for patients with poor performance status and pleural effusion until better treatments are developed.

Outcome of patients with lung cancer detected by mass screening versus presentation with symptoms　　　　　　　　　　　　　　　
H Satoh; H Ishikawa; YT Yamashita; T Naito; H Takahashi; H Kamma; Y Saito; M Ohtsuka; S Hasegawa
ANTICANCER RESEARCH, 01 May 1997
Lung cancers in the early stages are frequently detected via mass screening in Japan. The aim of this study is to evaluate the outcome of patients with lung cancer detected via mass screening and to compare them to those in whom the malignancy was detected by symptoms. A total of 774 untreated patients with lung cancer who were admitted to Department of Respiratory Medicine, Tsukuba University Hospital over a 20 year period up to 1995, were analyzed with reference to their reasons for detection of the cancer. In the mass screened group(116 patients), 50.0% of lung cancel was detected at stage I of TNM classification while only 8.2% of patients with symptoms(561 patients) had stage I lung cancel (p=0.0001). As lung cancels detected via mass screening were more often at operable stage (stage I, II or IIIA) (p=0.0001), surgical treatment was chosen more frequently in the mass screened group (p=0.0001). The outcome of patients with lung cancer detected via mass screening was move favorable than that of the patients detected by their symptoms (p=0.0002). The early detection of lung cancel via mass screening contributes to improvement of the outcome.

Serum sialyl Lewis X-i antigen levels in non-small cell lung cancer: Correlation with distant metastasis and survival
H Satoh; H Ishikawa; H Kamma; YT Yamashita; H Takahashi; M Ohtsuka; S Hasegawa
CLINICAL CANCER RESEARCH, 01 Apr. 1997
To evaluate the correlation between serum levels of sialyl Lewis X-i antigen and distant metastasis and survival in patients with non-small cell lung cancer (NSCLC), we measured the serum levels of the tumor marker in 371 patients with untreated NSCLC, The sialyl Lewis X-i antigen level was measured using a RIA kit, In patients with adenocarcinoma or other NSCLC subtypes, there was a correlation between serum sialyl Lewis X-i antigen and stage of the disease (P = 0.0001 and P = 0.0015, respectively), Levels of the marker varied significantly depending on the number of metastatic organs in adenocarcinoma (P 0.0089) and in other NSCLC subtypes (P = 0.002), Univariate analysis showed that survival of NSCLC patients with high (more than 100 units/ml) sialyl Lewis X-i antigen levels was significantly poorer than that of patients with low antigen levels (P = 0.0001), Multivariate analysis using Cox's proportional hazard model showed that high sialyl Lewis X-i antigen levels correlated significantly with poor survival (P = 0.004), Our data suggest that a high serum level of sialyl Lewis X-i antigen seems to be an indicator of the presence of metastasis and might indicate the need for a careful investigation of all putative metastatic sites. The serum levels of sialyl Lewis X-i antigen may reflect the extension of metastasis and would be helpful in considering treatment options.

Gender differences in lifestyles of the middle-aged and the elderly--a study in Satomi village, Ibaraki, Japan
T. Saito; C. Sakuragi; M. Ueji; H. Takahashi; K. Kano
[Nippon kōshū eisei zasshi] Japanese journal of public health, 1997

Does Gender Make a Difference in the Risk of Falls? A Japanese Study　　　　　　　　　　　　　　　
M.Suzuki; Y. Shimamoto; I Kawamura; Hideto Takahashi
Journal of Gerontological Nursing, 1997

ハワイ在住日系人中高年者の癌予防に関連した生活習慣についての調査研究　　　　　　　　　　　　　　　
Nov. 1995

A Study on Cancer Mortality Patterns in Ibaraki Prefecture by Multivariate Analysis
Mayumi Horikawa; Hideto Takahashi; Katsumi Kano
Tsukuba Environmental Studies, 1992

THE RATE OF CONVERGENCE OF FISHER INFORMATION FOR TYPE II CENSORED SAMPLE
Hideto Takahashi; Nariaki Sugiura
Journal of Japan Statistics Society, 1989
The convergence rate of the Fisher information for Type II right censored sample standardized by sample size n as n tends to infinity is shown to be O(n^-1/2+γ) for any positive constant γ less than 1/2 when the censoring rate converges to a constant lying in the interval (0, 1). This is proved by rewriting the Mehrotra, Johnson and Bhattacharyya [5]'s expression of the exact Fisher information in terms of the tail probability of binomial distribution and applying the Okamoto [6]'s inequalities. The multiparameter case is also studied.

Response to the letter of Midorikawa et al.
Hideto Takahashi; Seiji Yasumura; Kunihiko Takahashi; Tetsuya Ohira; Hiroki Shimura; Hitoshi Ohto; Satoru Suzuki; Shinichi Suzuki; Tetsuo Ishikawa; Satoshi Suzuki; Enbo Ma; Masanori Nagao; Susumu Yokoya; Kenji Kamiya
EClinicalMedicine, Feb. 2025

Corrigendum to "Outcomes of advanced care management in home-based long-term care: A retrospective population-based observational study" [Int. J. Nurs. Stud. 158 (2024) 104862].
Sakiko Itoh; Takahiro Mori; Xueying Jin; Tomoko Ito; Jun Komiyama; Naoaki Kuroda; Kazuaki Uda; Rumiko Tsuchiya-Ito; Xi Vivien Wu; Kana Kodama; Hideto Takahashi; Toshihiro Takeda; Nanako Tamiya
International journal of nursing studies, Dec. 2024

地域包括ケアシステムにおいて活用可能な国際生活機能分類(ICF)による多領域にまたがる評価手法の確立に資する研究 福祉領域におけるICFを用いた評価の確立に関する研究
2021

平成28年生活のしづらさ等に関する調査(全国在宅障害児・者実態調査)等の国際生活機能分類とのmapping．
2020

障害認定基準および障害福祉データの今後のあり方に関する研究
2020

障害認定基準および障害福祉データの今後のあり方に関する研究
2020

ICF活用の実際と展望(第3回)統計への活用
Jul. 2019

中年者の日常生活動作の保持に有効な運動・スポーツの内容　　　　　　　　　　　　　　　
武田 文; 門間, 貴史; 高橋 秀人; 野口 晴子; 田宮 菜奈子
厚生労働科学研究費補助金循環器疾患・糖尿病等生活習慣病対策総合研究事業「健康寿命及び地域格差の要因分析と健康増進対策の効果検証に関する研究」平成30年度総括・分担研究報告書, May 2019

健康寿命延伸および健康格差縮小に有効な中年者の運動・スポーツの内容　　　　　　　　　　　　　　　
武田 文; 門間, 貴史; 高橋 秀人; 野口 晴子; 田宮 菜奈子
厚生労働科学研究費補助金循環器疾患・糖尿病等生活習慣病対策総合研究事業「健康寿命及び地域格差の要因分析と健康増進対策の効果検証に関する研究」平成30年度総合研究報告書, May 2019

国連障害者権利条約（CRPD）と国際生活機能分類（ICF）統計資料収集等の枠組みに関する諸外国（スイス、ドイツ）の取り組みについて
14 Mar. 2019

The Authors Respond
Tetsuya Ohira; Hideto Takahashi; Seiji Yasumura
Epidemiology, 01 Mar. 2019
Lippincott Williams and Wilkins

障害認定基準および障害福祉データの今後のあり方に関する研究「平成28年生活のしづらさなどに関する調査(厚生労働省)」と国際生活機能分類(ICF)とのマッピング
2019

福島県内外における自殺の動向に関する研究　　　　　　　　　　　　　　　
2019

わが国の地域指標(社会指標)に求められる項目－国際生活機能分類(ICF)の観点から－　　　　　　　　　　　　　　　
2019

わが国の社会統計に求められる項目—ICFの観点から「生活のしづらさなどに関する調査」について—．　　　　　　　　　　　　　　　
2019

介護給付費等実態調査を用いた生命表法による「境界期健康期間」の定義とその推定および要介護２移行率の改善による境界期健康期間の延長に関するシミュレーションに基づく検討-　　　　　　　　　　　　　　　
2019

介護給付費等実態調査を用いた生命表法による「境界期健康期間」の定義とその推定および要介護２移行率の改善による境界期健康期間の延長に関するシミュレーションに基づく検討-　　　　　　　　　　　　　　　
2019

わが国の口腔保健について今後求められる指標に関する検討—統計学的観点から—　　　　　　　　　　　　　　　
2019

わが国の社会統計に求められる項目 －ICFの観点から「生活のしづらさなどに関する調査」について－　　　　　　　　　　　　　　　
2019

わが国の地域指標(社会指標) に求められる項目 - 国際生活機能分類(ICF)の観点から -　　　　　　　　　　　　　　　
2019

職域健診機会を利用した検査機会拡大のための新たな HIV 検査体制の研究 -7企業による結果の解析-　　　　　　　　　　　　　　　
2019

職域健診機会を利用した検査機会拡大のための新たな HIV 検査体制の研究-統計解析 総合報告書　　　　　　　　　　　　　　　
2019

在宅生活継続のための二次データを活用した実証分析　　　　　　　　　　　　　　　
2019

重度要介護高齢者における訪問診療および往診の利用と在宅生活継続の関連　　　　　　　　　　　　　　　
2019

家族介護者の長時間介護に関連する日常生活動作　　　　　　　　　　　　　　　
2019

市区町村別の重度要介護高齢者の在宅生活指標に関連する地域特性　　　　　　　　　　　　　　　
2019

重度要介護高齢者における介護保険サービスの利用と在宅生活継続の関連　　　　　　　　　　　　　　　
2019

中年者における運動・スポーツ活動の具体的実施方法と健康寿命との関係―中高年者縦断調査による解析―　　　　　　　　　　　　　　　
武田 文; 門間, 貴史; 高橋 秀人; 野口 晴子; 田宮 菜奈子
厚生労働科学研究費補助金循環器疾患・糖尿病等生活習慣病対策総合研究事業「健康寿命及び地域格差の要因分析と健康増進対策の効果検証に関する研究」平成29年度総括・分担研究報告書, May 2018

介護保険事業(支援)計画に役立つ地域指標－全国介護レセプト等を用いて　　　　　　　　　　　　　　　
2018

医療介護情報の連結方法の検証とロジックの構築及び医療介護の地域差分析:効果的な医療-介護の二次データ活用システム構築のためのヘルスサービスリサーチ　　　　　　　　　　　　　　　
2018

福島県内外における自殺の動向に関する研究　　　　　　　　　　　　　　　
2018

生活のしづらさ調査と国際生活機能分類(ICF)とのmapping　　　　　　　　　　　　　　　
2018

地域指標としての国際生活機能分類(ICF)の可能性について　　　　　　　　　　　　　　　
2018

職域での健診機会を利用した検査機会拡大のための新たな HIV 検査体制の研究に関する統計解析　　　　　　　　　　　　　　　
2018

管理的立場にある市町村の保健師の人材育成に関する研究 モデル地区での研修効果の推定および全国への汎用性に関する研究　　　　　　　　　　　　　　　
2018

管理的立場にある市町村の保健師の人材育成に関する研究 モデル地区での研修効果の推定および全国への汎用性に関する研究　　　　　　　　　　　　　　　
2018

小児期肥大型心筋症の特徴と予後に関する研究　　　　　　　　　　　　　　　
2018

小児期心筋症の全体像に関する研究　　　　　　　　　　　　　　　
2018

Study on the Development and Representativeness of the National Long-Term Care Insurance Claims Data and the Comprehensive Survey of Living Conditions　　　　　　　　　　　　　　　
Apr. 2017

Resident and facility characteristics associated with care-need level deterioration in long-term care welfare facilities in Japan　　　　　　　　　　　　　　　
2017

介護給付費等実態調査を用いた境界期健康寿命の推定　　　　　　　　　　　　　　　
2017

地域包括ケア実現のためのヘルスサービスリサーチ-二次データ活用システム構築による多角的エビデンス創出拠点-　　　　　　　　　　　　　　　
2017

日本における行政データの活用を模索するー『介護給付費実態調査』・『人口動態調査(死亡票)』のLinkage(照合)による生涯介護費用の推計ー　　　　　　　　　　　　　　　
2017

中高年齢期におけるソーシャル・ネットワークと抑うつとの関連性に関する実証研究ー『中高年縦断調査』による検証結果から－　　　　　　　　　　　　　　　
2017

有料老人ホームにおける要介護変化を用いたケアの質の指標の開発及び応用　　　　　　　　　　　　　　　
2017

介護レセプトデータを用いた在宅期間の指標化-観察期間による打ち切りに関する検討-　　　　　　　　　　　　　　　
2017

甲状腺がんの進展数理モデルの開発に関する研究　　　　　　　　　　　　　　　
2017

がん対策推進基本計画の効果検証と目標設定に関する研究　　　　　　　　　　　　　　　
2017

甲状腺がんの進展数理モデルの開発に関する研究　　　　　　　　　　　　　　　
2017

がん対策推進基本計画の効果検証と目標設定に関する研究
2017

小児期心筋症の心電図学的抽出基準,心臓超音波学的診断基準の作成と遺伝学的検査を反映した診療ガイドラインの作成に関する研究 心筋症患児情報の収集―二次調査結果について―
吉永正夫; 長嶋正實; 田内宣生; 堀米仁志; 岩本眞理; 立野滋; 市田蕗子; 住友直方; 大野聖子; 太田邦雄; 蒔田直昌; 緒方裕光; 高橋秀人; 堀江稔; 安田和志; 西原栄起; 廣野恵一; 鮎沢衛; 畑忠善; 櫨木大祐
小児期心筋症の心電図学的抽出基準、心臓超音波学的診断基準の作成と遺伝学的検査を反映した診療ガイドラインの作成に関する研究 平成28年度 総括・分担研究報告書(Web), 2017

Re: Thyroid Cancer Among Young People in Fukushima Respond
Hideto Takahashi; Tetsuya Ohira; Akira Ohtsuru; Hiroki Shimura; Kumiko Tsuboi; Seiji Yasumura; Koichi Tanigawa; Sanae Midorikawa; Satoru Suzuki
EPIDEMIOLOGY, 2017
LIPPINCOTT WILLIAMS & WILKINS

A Phase II Study of Bold Delayed Local Control Strategy in Children with High Risk Neuroblastoma: Japan Neuroblastoma Study Group (JN-H-11) Trial
H. Shichino; H. Mugishima; K. Matsumoto; T. Hishiki; T. Iehara; A. Yoneda; T. Soejima; T. Takimoto; H. Takahashi; S. Teramukai; T. Kamijo; A. Nakazawa; T. Fukushima; H. Hosoi; T. Tajiri; A. Nakagawara
PEDIATRIC BLOOD & CANCER, Nov. 2016

Re: Thyroid Cancer Among Young People in Fukushima.
Hideto Takahashi; Tetsuya Ohira; Seiji Yasumura; Kenneth E Nollet; Akira Ohtsuru; Koichi Tanigawa; Masafumi Abe; Hitoshi Ohto
Epidemiology (Cambridge, Mass.), May 2016

To the editor
Hideto Takahashi; Tetsuya Ohira; Seiji Yasumura; Kenneth E. Nollet; Akira Ohtsuru; Koichi Tanigawa; Masafumi Abe; Hitoshi Ohto
Epidemiology, 2016
Lippincott Williams and Wilkins

介護給付費等実態調査を用いた境界期健康関連指標について　　　　　　　　　　　　　　　
2016

Burden of chronic diseases in Japan: the Longitudinal Survey of Middle-age and Elderly Persons,2005-2013　　　　　　　　　　　　　　　
2016

Developing and applying Care level change indicatiors in Special nursing home in Japan　　　　　　　　　　　　　　　
2016

乳幼児突然死症候群（ＳＩＤＳ）および乳幼児突発性危急事態（ＡＬＴＥ）の病態解明等と死亡数減少のための研究　　　　　　　　　　　　　　　
2015

Survey Research on Disease Trends Inside and Outside Fukushima Prefecture　　　　　　　　　　　　　　　
2015

小学生の心血管危険因子値の基準値に関する検討
2015

Latent class growth model による小児期肥満出現時期の検討　　　　　　　　　　　　　　　
2015

小児期生活習慣病における内臓脂肪,皮下脂肪量と脈波伝伝搬速度の検討　　　　　　　　　　　　　　　
2015

幼児,小,中,高校生の体格値,心血管危険因子値と本人, 保護者の生活習慣の関連　　　　　　　　　　　　　　　
2015

幼児,小,中,高校生の体格値,心血管危険因子値の統計値に関する研究　　　　　　　　　　　　　　　
2015

中学生の生活習慣(早寝, 早起き, 朝ごはん)と自尊感情　　　　　　　　　　　　　　　
2015

グローバルエイジングへの国境なき挑戦ー経験の共有と尊重を支える日本発学際ネットワークによる提言に関する研究 グローバルエイジング時代の福祉研究にむけて　　　　　　　　　　　　　　　
2015

英国におけるソーシャルケアの改善に向けた「ゼロからの出発(ZBR)」プロジェクトの紹介　　　　　　　　　　　　　　　
2015

Ethics statements in original articles published beyond epidemiological journals in Japan　　　　　　　　　　　　　　　
TAKAHASHI; Hideto; MORIYAMA; Yoko; TAMIYA; Nanako; MA; Enbo
The 25th Annual Scientific Meeting of the Japan Epidemiological Association, 2015

Change in smoking behavior after a disaster: a study of evacuees in Fukushima after the Great East Japan Earthquake　　　　　　　　　　　　　　　
The 25th Annual Scientific Meeting of the Japan Epidemiological Association, 2015

The association between living argementant dietry inake among evacuees after the Great East Japan Eaithquake, The Fukushima Health Management Survey　　　　　　　　　　　　　　　
ZHANG; Wen; OHIRA Tetsuya; YUUKI; Michiko; HARIGANE; Mayumi、 HORIKOSHI; Naoko"; SUZUKI; Yuriko; OTSURU; Akira; YABE; Hirooki; MAEDA; Masaharu; NAGAI; Masato NAKANO; Hironori; TAKAHASHI; Hideto; YASUMURA; Seiji; KAMIYA; Kenji; YAMASHITA; Shunichi; ABE; Masafumi; for the Fukushima Health Management Survey Group.
The 25th Annual Scientific Meeting of the Japan Epidemiological Association, 2015

CHARACTERTICS OF IMAGE DEFINED RISK FACTORS (IDRFS) IN PATIENTS ENROLLED THE LOW RISK PROTOCOL (JNB-L-10) FROM THE JAPANESE NEUROBLASTOMA STUDY GROUP (JNBSG)
A. Yoneda; T. Tajiri; T. Iehara; M. Kitamura; A. Nakazawa; H. Takahashi; T. Takimoto; A. Nakagawara
PEDIATRIC BLOOD & CANCER, Dec. 2014

未成年者,特に幼児,小・中学生の糖尿病等の生活習慣病予防のための総合検診のあり方に関する研究 幼児,小・中学生の心血管危険因子値と本人,保護者の生活習慣との関係
2014

未成年者,特に幼児,小・中学生の糖尿病等の生活習慣病予防のための総合検診のあり方に関する研究 幼児,小・中学生の個々の生活習慣病の基準値作成に関する研究
2014

東日本大震災による避難にともなう環境変化と喫煙率に関する報告：県民健康調査から
2014

A pilot study to explore actual monthly consumption of the people under the Public Livelihood Assistance Program(PLAP) in Japan - A Receipt Study based on ethics -　　　　　　　　　　　　　　　
TAKAHASHI, Hideto
The 1st International Conference on Global Aging Tsukuba; ,,, 2014

The Cost Effectiveness Analysis of Electrocardiogram　　　　　　　　　　　　　　　
[TAKAHASHI, Hideto; YOSHINAGA, Masao; MA, Enbo.]
The 20th IEA World Congress of Epidemiology;, 2014

福島県「県民健康調査」について　　　　　　　　　　　　　　　
2014

介護老人福祉施設における軽度要介護者の入所中止政策に向けて－性別にみた実態把握　　　　　　　　　　　　　　　
2014

わが国の一人あたり介護サービス利用点数－全国「介護給付費調査」の個票データより－　　　　　　　　　　　　　　　
2014

福祉研究雑誌に掲載された原著等論文における研究倫理の記載について　　　　　　　　　　　　　　　
2014

『未成年者,特に幼児,小・中学生の糖尿病等の生活習慣病予防のための総合検診のあり方に関する研究』幼児,小・中学生の個々の生活習慣病の基準値作成に関する研究
2013

幼児および小中学生の生活習慣病基準値作成に関する研究
2013

ベイズ法を用いた有効性連続データ及び毒性二値データに基づく用量探索アプローチの第Ⅱ相試験への応用　　　　　　　　　　　　　　　
2013

幼児、小・中学生の心血管危険因子値に与える本人、保護者の生活習慣の影響　　　　　　　　　　　　　　　
2013

本邦における地域在住高齢者の死亡発見を遅らせる要因　　　　　　　　　　　　　　　
2013

福祉疫学研究におけるサンプルの代表制のゆがみについて　　　　　　　　　　　　　　　
2012

介護保険特定施設の利用者数の経年変化と都道府県間の移動に関する研究　　　　　　　　　　　　　　　
2012

Challenge of epidemiological methodology for welfare study.　　　　　　　　　　　　　　　
Hideto Takahashi
Abstract Book（Human Biology Symposium, The 3rd leading Graduate Schools International Conference, The 7th Tsukuba Medical Science Research Meeting）, 2012

肝細胞癌に対する少分割高線量陽子線治療後の放射線起因性肋骨骨折リスク因子解析　　　　　　　　　　　　　　　
2012

学級閉鎖の有効性に関する研究―新型インフルエンザ流行時の小学校におけるクラス内欠席者割合と実施日数より予測される学級閉鎖後の欠席割合―
2012

腎疾患重症化予防のための戦略研究第10回 クラスターランダム化比較試験においてクラスターはどのような影響を与えるか-統計学的観点から-　　　　　　　　　　　　　　　
2012

生活保護者の消費実態調査の可能性について―A自治体におけるレシートを用いた調査(パイロット研究)―　　　　　　　　　　　　　　　
2012

福祉・介護サービス研究における疫学手法の応用に関する研究　　　　　　　　　　　　　　　
2012

厚生労働科学研究費補助金（政策科学総合研究事業(政策科学推進研究事業)）福祉・介護サービスの質向上のためのアウトカム評価拠点―実態評価から改善へのＰＤＣＡサイクルの実現―平成２３年度総合・総括・分担研究報告書　　　　　　　　　　　　　　　
田宮菜奈子; 宮石智; 山崎健太郎; 大久保一郎; 川口孝泰; 玉岡晃; 徳田克己; 本澤巳代子; 陳礼美; 高橋秀人; 柏木聖代; 加藤剛平; 松澤明美
*EMPTY*, Jan. 2012

進行神経芽腫に対し原発巣切除術を含む局所療法を大量化学療法に遅延させて行う治療計画の早期第II相臨床試験　　　　　　　　　　　　　　　
Nov. 2011

世界に発信する内分泌外科の臨床と基礎研究 甲状腺乳頭癌に対する内視鏡補助下甲状腺切除+頸部リンパ節D2郭清の有効性、安全性の確認(第一報)　　　　　　　　　　　　　　　
Jun. 2011

乳児期QT延長症候群の診断基準と治療アルゴリズム作成による突然死予防に関する研究 フィージビリティースタディーのための暫定基準作成に関する研究
2011

乳児期QT延長症候群の診断アルゴリズム作成に関する検討　　　　　　　　　　　　　　　
2011

階層構造のあるクラスターモデルにおけるクラスター効果について　　　　　　　　　　　　　　　
2011

神経芽腫低・中間リスク群に対する臨床研究におけるIDRFの評価と外科治療ガイドライン　　　　　　　　　　　　　　　
2011

神経芽腫低リスク群・中間リスク群　　　　　　　　　　　　　　　
2011

甲状腺乳頭癌に対する内視鏡補助下甲状腺切除＋頸部リンパ節D2郭清の有効性，安全性の確認：第一報．　　　　　　　　　　　　　　　
2011

家族介護者同居の居宅サービス利用高齢者における在宅継続に関連する要因―介護保険給付レセプトを用いた分析から―　　　　　　　　　　　　　　　
2011

2年間における要介護度の推移人数および推移確率（2003年4月～2005年4月におけるサービス利用者の分析）　　　　　　　　　　　　　　　
2011

EBMに基づいた遺伝性不整脈における薬物の治療効果判定と治療ガイドライン作成のための統計学的手法の確立　　　　　　　　　　　　　　　
2011

Trends of cancer mortality in Japan, 1950-2004: Age-period-and cohort analysis.　　　　　　　　　　　　　　　
Masahiro Tanaka; Enbo Ma; Hideo Tanaka; Hideto Takahashi
World Cancer Congress 2010（Shenzhen, China）, 2010

国民年金と生活保護に関する実質的受給額の比較に関する研究　　　　　　　　　　　　　　　
2010

国民年金と生活保護に関する実質的受給額の比較　　　　　　　　　　　　　　　
2010

希少疾患臨床試験における中間解析に関する研究　　　　　　　　　　　　　　　
2010

家族介護者の続柄の違いによる被介護者の生命予後に関する研究　　　　　　　　　　　　　　　
2010

PE-413 Association Between the Accumulation of Cardiovascular Risk Factors and Adipokine or Individual Risk Factor Levels in Adolescent Volunteers(PE069,Preventive Medicine/Epidemiology/Education 2 (H),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)
Yoshinaga Masao; Shinomiya Masaki; Miyazaki Ayumi; Tanaka Yuji; Kuribayashi Nobuichi; Ichida Fukiko; Takahashi Hideto
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2009
Japanese Circulation Society

高校生を対象としたメタボリックシンドローム予防健診 －鹿児島県・千葉県・富山県における健診結果の比較－　　　　　　　　　　　　　　　
2009

小児期肥満治療の介入成績と治療の費用対効果に関する研究　　　　　　　　　　　　　　　
2009

高校生の生活習慣病予防検診　　　　　　　　　　　　　　　
2009

希少疾患に対する臨床試験におけるサイズ設計式の比較研究 -生存時間解析におけるLawlesss式とLachin式、およびFreedmand式の比較-　　　　　　　　　　　　　　　
2009

思春期（高校生）の生活習慣病予防に関する提言―ガイドライン策定に向けて―　　　　　　　　　　　　　　　
2009

生活習慣病の集積が個々の生活習慣病の値に及ぼす影響に関する研究　　　　　　　　　　　　　　　
2009

個々の心血管危険因子値と生活習慣・食習慣との関係に関する研究　　　　　　　　　　　　　　　
2009

高校生における腹部内臓脂肪蓄積の実態とそれに及ぼす要因に関する研究　　　　　　　　　　　　　　　
2009

富山県T高校生における生活習慣病予防検診結果　　　　　　　　　　　　　　　
2009

鹿児島県・千葉県・富山県高校生における生活習慣病予防検診結果の地域特性に関する研究　　　　　　　　　　　　　　　
2009

幼児における生活習慣病関連指標としての血液凝固線溶系とアディポカインに関する研究―健常幼児を対象とした標準値の確立―　　　　　　　　　　　　　　　
2009

Fridericia補正による小児期のQT延長の基準値の検討
2008

Fridericia補正による小児期のQT延長,QT短縮の基準値の検討
2008

居住費・食費の負担の見直しによる介護保険3施設への影響 介護保険給付費実態調査月報から
2008

かかりつけ医/非腎臓専門医と腎臓専門医の協力を促進する慢性腎臓病患者の重症化予防のための診療システムの有用性を検討する研究　　　　　　　　　　　　　　　
2008

神経芽腫臨床試験においてサイズにより受ける制約に関する研究　　　　　　　　　　　　　　　
2008

居住費・職k費の負担の見直しによる下位語保険施設への影響 介護保険給付費実態調査月報から　　　　　　　　　　　　　　　
林原好美; 田宮菜奈子; 高橋秀人; 柏木聖代; 大久保一郎
厚生の指標, Jan. 2008, [Reviewed]

わが国の健診における新規検尿異常出現率　　　　　　　　　　　　　　　
渡邊 文代; 富田 知栄; 萩原 正大; 金子 修三; 清水 芳男; 平山 暁; 楊 景堯; 高橋 秀人; 西連地 利巳; 石田 久美子; 山縣 邦弘
日本腎臓学会誌, Apr. 2007
(一社)日本腎臓学会

健康日本21地方計画策定支援を目的とした地域診断ツールの開発
2005

ブラックボックスにはしたくない生物統計学のＡＢＣ　　　　　　　　　　　　　　　
2005

各種健康法の実践とそれに要した費用に関する調査研究　　　　　　　　　　　　　　　
2004

代替療法の実態に関する社会調査研究　　　　　　　　　　　　　　　
2004

Patterns and predictors of failure after curative resections of carcinoma of the ampulla of Vater
T Todoroki; N Koike; Y Morishita; T Kawamoto; N Ohkohchi; J Shoda; Y Fukuda; H Takahashi
ANNALS OF SURGICAL ONCOLOGY, Nov. 2003
Background: Curative resection does not always equate with long-term survival. The aim was to identify patterns and predictors of failure and independent factors of prognosis after curative resection.
Methods: Sixty-six patients with ampullary carcinoma who underwent surgical intervention were reviewed. Fifty-nine patients underwent pancreaticoduodenectomy. Cox regression analysis, log-rank test, Fisher exact test, or chi(2) test was used.
Results: No patient died as a result of surgery; major complications occurred in three, and the 5-year survival rate after curative resection (n = 55) was 52.6%. Significant survival predictors were preoperative serum carcinoembryonic antigen level; gross tumor appearance; tumor, node, and tumor node metastasis stage; and microscopic lymphatic vessel and venous invasion in the primary tumor. Multivariate analysis demonstrated that lymphatic vessel invasion, tumor, and tumor node metastasis stage were significant independent prognostic factors. No patient experienced locoregional failure alone; all 24 relapsed patients had distant failure, and six of them had both. The liver was the most frequent metastatic organ, followed by nodes, peritoneum, lung, and bone. The carcinoembryonic antigen and carbohydrate antigen levels and lymphatic vessel and venous invasion were significant predictors of distant failure, and the mean time to relapse was 13 (range, 0.7-33) months.
Conclusions: Curative resection is associated with significant survival; however, effective systemic adjuvant therapy is needed to prevent distant failure for patients with elevated carcinoembryonic antigen and carbohydrate antigen levels or positive lymphatic vessel or venous invasion. A 3-year follow-up period would be necessary to document relapses., LIPPINCOTT WILLIAMS & WILKINS

保健情報Webサイトにおける掲載内容の質的評価の試み
2003

今後の公衆衛生の発展に求められる情報の提供について　　　　　　　　　　　　　　　
2003

地域における長期的な循環器疾患予防対策が高齢者のADL,QOLおよび医療費に及ぼす影響－保健サービスの統計解析－　　　　　　　　　　　　　　　
2003

標準集団の疾患発生(死亡)数の確率変動を仮定した標準化発生率(死亡)比(SMR)の信頼区間の適用について
01 Jan. 2002

血友病／HIV-1感染者の生存時間と多剤併用療法導入後の臨床経過に関する追跡調査?血友病／HIV-1感染者との比較?
2002

血友病／HIV-1感染者の生存時間と多剤併用療法導入後の臨床経過に関する追跡調査?血友病／HIV-1感染者との比較?
2002

わが国における肺癌死亡の年齢-年次-出生コーホート解析
2002

循環器健診を中心とする地域における年齢・年次・出生コーホート解析　　　　　　　　　　　　　　　
2002

社会医学分野における質問紙調査のためのJavaクラスライブラリの構築
2001

Application Framework for Lifestyle Evaluation System to Prevent Lifestyle-Related Diseases.
岡田昌史; 高田彰; 桜木智江; 高橋秀人; 加納克己
医療情報学, 2001

Evaluating Treatments of Rapidly Progressive Glomerulonephritis When the Response is Potentially Non-ignorably Missing.
Ryoko Tobiishi; Yuichiro Kanazawa; Hideto Takahashi; Naoto Yamaguchi; Kunihiro Yamagata; Tetsuo Koyama
Jpn J Biometrics, 2000
Rapidly progressive glomerulonephritis (RPGN) is a life-theatening nephritis with a rapid decline in renal function. In this paper, we examine the three alternative treatments relative to the most commonly-used oral steroid for the two prevalent forms of RPGN, called PautiCrGN and MPA, in Japan. The response "Exitus" is potentially non-ignorably missing because the data were reported by those who administered the treatment. We use the method proposed in Ibrahim (1996) for estimating parameters in binomial logistic model when the missing response is potentially nonignorable. For PautiCrGN patients, we found that the three alternative treatments did not seem to affect the survival of the patients. MPA patients who underwent the steroidpulse or the cyclophosphamide with the oral steroid, seemed less likely to have survived compared with those who received the oral steroid only. For PautiCrGN patients, their exitus was not non-ignorably missing at first sight, and its missingness increased when the patients received the combined treatment. If, however, steroidpulse and/ or cyclophosphamide were additionally prescribed as the patients' conditions deteriorated, then the observed correlation above may prove the existence of non-ignorably missing exitus instead, because the exitus of serious patients might have been under-reported precisely because of their conditions., The Biometric Society of Japan

骨粗鬆症による骨折と運動との関連についての症例対照研究　　　　　　　　　　　　　　　
2000

医学生の喫煙習慣と卒前教育における課題　　　　　　　　　　　　　　　
2000

生活習慣評価機能を持つソフトウェア部品の開発
1999

前立腺癌患者用QOL調査票の評価　　　　　　　　　　　　　　　
1999

生活習慣病予防のためのｲﾝﾀｰﾈｯﾄを利用した調査　　　　　　　　　　　　　　　
1999

ANCA関連腎炎の疫学　　　　　　　　　　　　　　　
1999

2×2分割表の△検定における△の影響のシミュレーションによる評価
01 Jul. 1998

Java言語による生活習慣評価システムの開発
1998

Present state and prospects of countermeasure for renal insufficiency III. Cause and countermeasure of acute renal insufficiency 2. Rapidly progressive glomerulonephritis.
Nihon Naika Gakkai Kaishi, 1998
The Japanese Society of Internal Medicine

生活習慣評価および健康教育支援情報システムの開発　　　　　　　　　　　　　　　
1998

推薦入学定員の適正割合の推定　　　　　　　　　　　　　　　
1998

住民のニーズと調査対象者のメリットへの配慮からの「公衆衛生」　　　　　　　　　　　　　　　
1998

中高年者の健康生活習慣の性差について-茨城県里美村における調査研究-　　　　　　　　　　　　　　　
1997

過度の肥満と骨密度の関連に関する疫学的研究
1997

The Postgraduate Careers of the Graduates of the School of Medicine, University of Tsukuba, and Evaluation of the School Curriculum by the Graduates.:Evaluation of the School Curriculum by the Graduates
MORITA Rinko; KUDO Norio; KANO Katumi; TAKAHASHI Hideto; HAYASHI Hideo; OHNO Tadao; MITSUI Toshio; ABE Tsukasa
Igaku Kyoiku / Medical Education (Japan), 1997
The School of Medicine, University of Tsukuba, was founded in 1974 and had graduated 1, 561 students by 1994. From 1980 through 1987, 44% to 73% of graduates became hospital staff, 16% to 40% became university staff, and 0% to 8% became general practitioners. More than 80% of graduates did a 2-year residency (sotsugo-kenshu) at our university hospital and 40% completed a 6-year residency. Almost 10 years of postgraduate training was required to become an established medical practitioner. This length of time indicates that postgraduate training is the most important part of the medical career. About 80% of graduates earned doctor of philosophy (Ph. D.) degrees, whereas 93% became registered specialists, indicating that graduates tended to become specialists rather than to pursue Ph. D. degrees. This difference is more evident among female graduates: 85% became specialists whereas only 53% received a Ph. D. Most graduates considered the School of Medicine to have a good curriculum, but some younger graduates had complaints. The graduates chose their career specialties on the basis of their own interests and aptitudes. We should take these data into account to prepare a system of life-long education and learning., Japan Society for Medical Education

推薦入学定員の適正割合の推定　　　　　　　　　　　　　　　
1997

The Effectiveness of G-CSF on the Incidence of Febrile Neutropenia and Antibiotic Usage in Gynecologic Cancer Patients Receiving Chemotherapy
Saori Harada; Hajime Tsunoda; Hideto Takahashi; Yukinao Kohda; Katsumi Kano; Takeshi Kubo
Japanese Journal of Clinical Pharmacology and Therapeutics, 1997
The efficacy of recombinant granulocyte-colony stimulating factor (G-CSF) has been shown in clinical trials. However, the high cost of G-CSF has led to concern about its beneficial effects in clinical practice. Reviewing medical records of 57 gynecologic cancer patients with 250 courses of cytotoxic chemotherapy, we evaluated the effectiveness of G-CSF administration on the incidence of febrile neutropenia and on antibiotic usage. The courses were divided into two groups : “case” (post-marketing of G-CSF) and “control” (pre-marketing of G-CSF). Information on the blood cell count, regimen, age and number of days since the operation for both cases and controls was obtained from their medical records. Data of cases and controls were compared. In the analysis of odds ratios from the logistic regression model, there were no significant differences between case and control groups in terms of the incidence of febrile neutropenia and antibiotic usage for the treatment of febrile neutropenia. On the other hand, the incidence of antibiotic usage for the prevention of infection was significantly high in the case group (p <
0.05). These results may indicate that the effectiveness in G-CSF usage is probably dependent on physician's decision-making in the administration of the above agents. Further studies are warranted on the effectiveness of pharmaceutical agents in clinical practice as well as clinical trials. © 1997, The Japanese Society of Clinical Pharmacology and Therapeutics. All rights reserved., The Japanese Society of Clinical Pharmacology and Therapeutics

茨城県下９医療地域における肺癌1100例の検討：特に検診発見例による臨床的検討
1996

A Study of Osteoporosis Among Females Aged 50 Years and Over Using Mass Screening Data
KANO Katsumi; HAGA Masayuki; HOSODA Takako; SUZUKI Mizue; UEJI Masaru; TAKAHASHI Hideto; MOTEGI Kazuo
Japanese Journal of Health and Human Ecology, 1996
In order to identify factors that may contribute to osteoporosis, a cross sectional study of Japanese females over the age of 50 was conducted at 13 health centers in Ibaraki Prefecture in the period from December 1992 through March 1993 . Based on the criteria employed by the Orimo Research Group at the Ministy of Public Health and Welfare, 136 subjects were classified as having osteoporosis. Analysis of these data revealed several statistically significant differences between subjects with osteoporosis and the control group (n=680) . Some factors potentially thought to be associated with osteoporosis were not found to be statistically significant. Exercise was less frequent among those with osteoporosis in the group of subjects aged 60-69. The calcium intake of those subjects 70 and above was also significantly less for those with osteoporosis. Additionally, menopause occurred earlier among those with osteoporosis for subjects aged 50-69 . However, there was no significant difference between the control group and the group with osteoporosis in the age of menarche, nor in the rate of childbirth . Nor were statistically significant differences found between the groups in alcohol drinking, smoking or sun bathing. With the exception of serum P for those aged 50-59, there were also no significant differences between the groups in serum Ca, ALP or albumin. Regarding health status, the health of subjects aged from 50-59 with osteoporosis was significantly worse. For subjects aged 60-69, the rate of bone fractures was higher for subjects with osteoporosis, though there were no significant differences between the two groups in fall related injuries occurring in the previous year., The Japanese Society of Health and Human Ecology

ハワイ在住日系人中高年者のがん予防に関連した生活習慣についての調査研究
1996

身体活動のガン予防に関する疫学研究成果について-文献学的研究-
1996

中高年期女性の骨密度と運動歴との関連についての疫学調査研究-5,000人以上を対象にした骨粗鬆症検診デ-タを用いて-　　　　　　　　　　　　　　　
1996

高齢化を支える保健・医療等に関する生活情報システムの構築と効果的な活用に関する研究（科学技術庁依託研究）　　　　　　　　　　　　　　　
1996

Health Services Research for the Realization of Community-Based Integrated Care: Establishing a Hub for Generating Multidimensional Evidence through the Development of a Secondary Data Utilization System　　　　　　　　　　　　　　　
1995

YEARLY CHANGES AND GEOGRAPHICAL DISTRIBUTION OF ALLERGIC RHINITIS MORBIDITY ESTIMATED FROM RECORDS OF THE NATIONAL HEALTH INSURANCE
TAMURA Kenji; ONO Masaji; MURAKAMI Masataka; TAKAHASHI Hideto; SAIRENCHI Toshimi; TAMIYA Nanako; ARAI Takashi
Japanese journal of public health, 1995

骨粗鬆症に関する調査研究-茨城県内の中高年期の女性における骨粗鬆症の実態-
1995

成人病予防のための生活習慣診断システムの開発に関する研究　　　　　　　　　　　　　　　
1995

ハワイ在住の中高年日系人の健康生活習慣に関する調査研究　　　　　　　　　　　　　　　
1995

茨城県における保健情報システムについて-現状と課題-　　　　　　　　　　　　　　　
1995

VDT作業者に生まれた子供の性別、体重に関する調査研究-インタ-ネットを用いたアンケ-ト調査-
1995

出生コ-ホ-ト(Birth Cohort) に基づいた肺がんの瞬間危険率の予測に関する研究
1995

高齢化を支える保健・医療等に関する生活情報システム構築と効果的な活用に関する研究（科学技術庁依託研究）　　　　　　　　　　　　　　　
1995

５次以下の最良近似多項式を年齢区間死亡率に用いた平均寿命の予測に関する研究
1994

生活情報システム構築及び地域ネットワ?クの形成に関する研究（科学技術庁依託研究）　　　　　　　　　　　　　　　
1994

高齢者の転倒状況と転倒後の身体的変化に関する調査研究
1993

肺癌死亡率と虚血性心疾患死亡率との関係に関する考察 -日米比較研究-
1993

Type II censored normal sample による標準偏差の推定における M.L.E.の２次の bias
1993

英国における環境保健サーベイランス・システム
1993

Type II censored normal sample による平均の推定における M.L.E.の２次の bias
1993

わが国における転倒事故死に関する記述疫学的研究
1993

高齢者の転倒に関する調査研究 - 主として生活環境・生活習慣との関連について -　　　　　　　　　　　　　　　
1993

茨城県における地域がん登録システムについて
1993

高齢者の転倒経験に関する調査研究- 養護老人ホームの居住者を対象として -
1992

イギリスにおける環境保健サーベイランス・システム- small area health statistics unit (SAHSU)-
1992

基礎医学統計学 改訂第7版　　　　　　　　　　　　　　　
Apr. 2019

ヘルスサービスリサーチ入門 生活と調和した医療のために　　　　　　　　　　　　　　　
Contributor
2017

疫学辞典
Jul. 2010
9784819202220

エッセンシャル 社会・環境と健康(第2版)　　　　　　　　　　　　　　　
2007

看護大辞典　　　　　　　　　　　　　　　
2002

疫学概論 : 理論と方法
Mar. 2000
4254310838

2024年「生活のしづらさ調査」に基づく難病に関する研究
高橋秀人; 大夛賀政昭; 重田史絵; 山口佳小里
第36回日本疫学会学術総会 国際疫学会西太平洋地域 合同大会, Jan. 2026

難病および精神障害を有する人々の日常生活機能：日本における「令和4年度生活のしづらさ調査」に基づくICF分析　　　　　　　　　　　　　　　
高橋秀人; 大夛賀政昭; 重田史絵; 山口佳小里
WHO-FICネットワーク年次会合2025，Geneva, Switzerland，

Study on the Linkage Between ICD-11 Intractable Diseases, Mental Disorders, and Daily Functioning: An Example from the 2022 National Survey on the Living Conditions of Persons with Disabilities in Japan　　　　　　　　　　　　　　　
TAKAHASHI Hideto; OTAGA Masaaki; SHIGETA Fumie
The Japan Society for the Study of Social Welfare, 05 Oct. 2025

“Proportion of Missing External Radiation Dose Data and Imputation Results: The Fukushima Prefecture ‘Health Management Survey’”　　　　　　　　　　　　　　　
TAKAHASHI Hideto; YASUMURA Seiji; TAKAHASHI Kunihiko; OHIRA Tetsuya
2025 Annual Meeting of the Japanese Federation of Statistical Societies, 10 Sep. 2025

A Study on the Mathematical Competencies Required in the Model Core Curriculum for Pharmacy Education (Revised in FY2022)　　　　　　　　　　　　　　　
Hideto Takahashi; Masami Konuma; Takeshi Kubota; Masafumi Kaneko
The 10th Annual Conference of the Japanese Association for Pharmaceutical Education, 24 Aug. 2025

における薬学教育モデル・コア・カリキュラム（2022年改訂版）で要求される数学的能力　　　　　　　　　　　　　　　
高橋秀人; 濃沼政美; 窪田剛志; 金児正史
第12回 アジア薬科大学協会(AASP)カンファレンス 2025, 03 Aug. 2025

Association between the Washington Group Short Set (6 items) and the WHODAS 2.0 (12-item version)　　　　　　　　　　　　　　　
Hideto Takahashi; Masaaki Ohtaga; Fumie Shigeta; Kaori Yamaguchi
The 35th Annual Scientific Meeting of the Japan Epidemiological Association, 13 Feb. 2025

Study on Enhancing the Promotion of Awareness of HIV Infection in the Workplace
Yoshiyuki Yokomaku; Hideto Takahashi; Mayumi Imahashi; Tomohiro Ishimaru; Ai Hori; Tsuguru Ikushima; Masashi Masuda
Japan Public Health Association (JPHA), 29 Oct. 2025

Development of a Support System for the Long-Term Care Certification Review Process: Comments from Certification Committee Members　　　　　　　　　　　　　　　
Hideto Takahashi; Yoko Moriyama; Jun Komiyama; Tomoyuki Matsuda; Naoyuki Kuroda; Kazuaki Uda; Yoko Hamasaki; Ai Suzuki; Nanako Tamiya
Japan Public Health Association, 29 Oct. 2025

COVID-19パンデミック前後におけるがん患者の患者特性毎の在宅死割合の変化　　　　　　　　　　　　　　　
Oct. 2024

Scoring disability-related events by WHODAS 2.0 12-item version by applying optimal cutoff point-Japanese Data-　　　　　　　　　　　　　　　
高橋秀人

COVID-19 感染症流行からの時間経過と十大死因の超過死亡との関連性に関する検討　　　　　　　　　　　　　　　
Sep. 2024

WHODAS2.0 12項目バージョンを使用した障害関連イベントのスコアリング　　　　　　　　　　　　　　　
2024

要介護認定審査において一次判定から二次判定で介護度が変更された要因の探索　　　　　　　　　　　　　　　
Nov. 2023

COVID-19流行下における在留外国人と日本人の自殺率の動向比較　　　　　　　　　　　　　　　
Oct. 2023

世帯の職業別の未成年の自殺者割合およびコロナ後の自殺数の増減に関する検討　　　　　　　　　　　　　　　
Oct. 2023

要介護認定審査において一次判定から二次判定で介護度が変更された要因の探索　　　　　　　　　　　　　　　
Oct. 2023

Covid19感染症流行と超過死亡の程度との関連について　　　　　　　　　　　　　　　
Oct. 2023

要介護認定審査において一次判定から二次判定で介護度が変更された要因の探索　　　　　　　　　　　　　　　
Oct. 2023

家族介護者における年代別社会的ケア関連QOLの実態 現役世代介護者に着目して　　　　　　　　　　　　　　　
Oct. 2023

小児がんの外科治療と機能温存:どこまで取ってどこまで残すか Non-high-risk神経芽腫における臓器温存　　　　　　　　　　　　　　　
Apr. 2023

COVID-19の医療システムへの影響評価のためのNDBの活用の検討　　　　　　　　　　　　　　　
Feb. 2023

WHODAS2.0に基づく障害,主観的非健康意識に関する最適閾値の推定　　　　　　　　　　　　　　　
Feb. 2023

福島第一原発事故後の放射線被ばくと甲状腺がんとの関連についての症例対照研究 福島県県民健康調査　　　　　　　　　　　　　　　
Feb. 2023

「障害の有無」および「主観的健康意識の有無」に関するWHODAS2.0による最適閾値の推定-内閣府「令和元年度障害者統計の充実に関わる調査研究事業」データを用いて-　　　　　　　　　　　　　　　
2023

AIによる要介護認定審査支援の開発にむけた全国調査 主治医意見書と重度化の関係　　　　　　　　　　　　　　　
Sep. 2022

AIによる要介護認定審査支援の開発にむけた全国調査 認定審査の実施方法と実態　　　　　　　　　　　　　　　
Sep. 2022

日本成人の歯科検診受診状況と社会活動参加状況・運動実施状況との関連　　　　　　　　　　　　　　　
Jan. 2022

iTesting：新型コロナウイルス感染拡大期における保健所HIV等検査の実施体制に関する研究
The 35th Annual Meeting of the Japanese Society for AIDS Research, 2021

介護保険受給者台帳の資格喪失記録を死亡代理変数として使用することの妥当性の評価　　　　　　　　　　　　　　　
Nov. 2021

NDBを用いた全国民の性・年齢・都道府県別の一年間歯科受診割合と残存歯数の実態　　　　　　　　　　　　　　　
Nov. 2021

歯科レセプト情報「欠損歯式」の妥当性に関する検討　　　　　　　　　　　　　　　
Nov. 2021

The road to change in HIV testing policy in Japan based on anonymous free-of-charge HIV testing preventing SARS-CoV-2 infection.　　　　　　　　　　　　　　　
APHA Annual Meeting and Expo

障害福祉分野におけるICF項目を用いたサービス評価の検討 ― 3層D-Plusモデル評価マトリクスの枠組みから ―　　　　　　　　　　　　　　　
12 Sep. 2021

福祉事業評価に関わる3層D-Plus評価マトリクスの提案　　　　　　　　　　　　　　　
12 Sep. 2021

放射線曝露と甲状腺がん発症に関するコホート内症例対照研究(本格検査1回目までの結果)福島県民健康調査　　　　　　　　　　　　　　　
06 Sep. 2021

Nested matched case-control study to examine the association of thyroid-cancer with radiation-exposure in Fukushima Japan.　　　　　　　　　　　　　　　
World Congress of Epidemiology

家庭における受動喫煙が現在歯数に与える影響について　　　　　　　　　　　　　　　
Jul. 2021

高齢者の歯科受療実態と年齢、要介護度の関連 市町村医療介護連結レセプトデータを用いた横断研究　　　　　　　　　　　　　　　
Apr. 2021

標準化歯科疾患有訴者比(国民生活基礎調査)と標準化歯科診療行為算定比(NDBオープンデータ)との関連　　　　　　　　　　　　　　　
Apr. 2021

日本成人の歯科検診受診状況と年齢、性別、市郡、口腔保健状態との関連　　　　　　　　　　　　　　　
Apr. 2021

神経芽腫低リスクプロトコール(JN-L-10)におけるIDRFの検討
Apr. 2021

高齢者の歯科受療実態と年齢、要介護度の関連 市町村医療介護連結レセプトデータを用いた横断研究　　　　　　　　　　　　　　　
Apr. 2021

標準化歯科疾患有訴者比(国民生活基礎調査)と標準化歯科診療行為算定比(NDBオープンデータ)との関連　　　　　　　　　　　　　　　
Apr. 2021

日本成人の歯科検診受診状況と年齢、性別、市郡、口腔保健状態との関連　　　　　　　　　　　　　　　
Apr. 2021

神経芽腫低リスクプロトコール(JN-L-10)におけるIDRFの検討　　　　　　　　　　　　　　　
Apr. 2021

日本の歯科医療受療格差の検討 NDB公開データを用いた都道府県差の分析　　　　　　　　　　　　　　　
Jan. 2021

アウトカム指標として国際生活機能分類(ICF)を用いた福祉領域に関する文献研究　　　　　　　　　　　　　　　
Jan. 2021

日本の歯科医療受療格差の検討 NDB公開データを用いた都道府県差の分析　　　　　　　　　　　　　　　
Jan. 2021

Applying the ICF framework to measures in antipoverty programs in Japan　　　　　　　　　　　　　　　
TAKAHASHI Hideto; OHTAGA Masaaki; SHIGETA Fumie
WHO-FAMILY International Classifications Network Annual Meeting 2020, 19 Oct. 2020

40～74歳における婚姻状況と歯科の自覚症状に対する受療行動の関連　　　　　　　　　　　　　　　
19 Oct. 2020

国際生活機能分類(ICF)に基づく社会統計の特徴化－生活のしづらさ調査を例に－　　　　　　　　　　　　　　　
19 Oct. 2020

歯科レセプト情報「歯式」の妥当性に関する検討　　　　　　　　　　　　　　　
19 Oct. 2020

福祉事業所におけるWHODAS2.0を用いた支援効果の疫学的評価　　　　　　　　　　　　　　　
19 Oct. 2020

平成28年度歯科疾患実態調査を用いた都市規模別高齢者の咬合状態調査　　　　　　　　　　　　　　　
19 Oct. 2020

平成28年度歯科疾患実態調査を用いた都市規模別の口腔内状況と口腔保健行動の分析　　　　　　　　　　　　　　　
19 Oct. 2020

福島県内外の自殺の経年変化における増加変化点検出の検討　　　　　　　　　　　　　　　
08 Sep. 2020

Eichner分類を用いた成人の咬合状態に関する分析 平成28年歯科疾患実態調査の結果から　　　　　　　　　　　　　　　
Mar. 2020

福島県内外における自殺の経年変化
22 Feb. 2020

福島県民健康調査甲状腺検査結果に基づく疫学研究― 基礎から実践的な解釈にむけて―　　　　　　　　　　　　　　　
18 Feb. 2020

福祉疫学の推進に必要なわが国の社会統計の構築につい－国際生活機能分類（ICF）の観点から－　　　　　　　　　　　　　　　
14 Feb. 2020

就労継続支援B型事業所のアウトカム評価－ICF項目に基づく特徴化の試み－　　　　　　　　　　　　　　　
23 Oct. 2019

在宅要介護者と施設要介護者の死亡の場所の経年比較：病院から自宅へ、施設へ，　　　　　　　　　　　　　　　
23 Oct. 2019

要介護度２移行率改善による境界期健康期間の延伸度－シミュレーションに基づく検討－，　　　　　　　　　　　　　　　
23 Oct. 2019

都道府県の為の「市町村保健師管理者能力育成研修」ガイドライン開発，　　　　　　　　　　　　　　　
23 Oct. 2019

宮崎県における高齢者結核の早期発見と重症化予防のための多職種間連携システムの検討,　　　　　　　　　　　　　　　
23 Oct. 2019

夫婦の生活習慣病罹患の一致について，　　　　　　　　　　　　　　　
23 Oct. 2019

A TRIAL OF MAPPING OF ICF ELEMENTS TO AN EXISTING SOCIAL STATISTICS OF JAPAN.
TAKAHASHI Hideto; OTAGA Masaaki; HAYASHI Reiko
WHO-FIC Network Annual Meeting 2019 Banff, Canada, 10 Oct. 2019

都道府県の為の『市町村保健師管理者能力育成研修』ガイドライン開発　　　　　　　　　　　　　　　
Oct. 2019

就労継続支援B型事業所のアウトカム評価 ICF項目に基づく特徴化の試み　　　　　　　　　　　　　　　
Oct. 2019

国際生活機能分類(ICF)を基にした生活のしづらさ調査の網羅性について
21 Sep. 2019

福祉施設評価に関する先行研究Reviewからの考察― 国際生活機能分類（ICF）を踏まえたアウトカム評価の検討 ―
21 Sep. 2019

学校における心血管スクリーニングプログラムで小児期肥大型心筋症(HCM)を調べる左室厚増加の基準(Criteria for Increased Left Ventricular Thickness to Screen Childhood Hypertrophic Cardiomyopath0y(HCM) at a School-based Cardiovascular Screening Program)　　　　　　　　　　　　　　　
吉永 正夫; 西原 栄起; 畑 忠善; 阿部 勝己; 太田 邦雄; 立野 滋; 野村 裕一; 堀米 仁志; 市田 蕗子; 廣野 恵一; 岩本 眞理; 櫨木 大祐; 田内 宣生; 長嶋 正實; 高橋 秀人; 緒方 裕光; 「小児期心筋症の心電図学的抽出基準、心臓超音波学的診断基準の作成と遺伝学的検査を反映した診療ガイドラインの作成に関する研究」班
日本循環器学会学術集会抄録集, Mar. 2019, (一社)日本循環器学会

学校における心血管スクリーニングプログラムで小児期肥大型心筋症(HCM)を調べる左室厚増加の基準(Criteria for Increased Left Ventricular Thickness to Screen Childhood Hypertrophic Cardiomyopath0y(HCM) at a School-based Cardiovascular Screening Program)　　　　　　　　　　　　　　　
吉永 正夫; 西原 栄起; 畑 忠善; 阿部 勝己; 太田 邦雄; 立野 滋; 野村 裕一; 堀米 仁志; 市田 蕗子; 廣野 恵一; 岩本 眞理; 櫨木 大祐; 田内 宣生; 長嶋 正實; 高橋 秀人; 緒方 裕光; 小児期心筋症の心電図学的抽出基準; 心臓超音波学的診断基準の作成と遺伝学的検査を反映した診療ガイドラインの作成に関する研究; 班
日本循環器学会学術集会抄録集, Mar. 2019, (一社)日本循環器学会

県が主催した市町村保健師管理者能力育成モデル研修の効果　　　　　　　　　　　　　　　
成木 弘子; 高橋 秀人; 森永 裕美子; 横山 徹爾
日本公衆衛生学会総会抄録集, Oct. 2018, 日本公衆衛生学会

自治体との協働により構築した地域包括ケアのアウトカム評価の枠組みと体系の提案　　　　　　　　　　　　　　　
Oct. 2018

日本人中年者における運動・スポーツの具体的実施方法　　　　　　　　　　　　　　　
門間, 貴史; 野口, 晴子; 高橋, 秀人; 田宮, 菜奈子; 武田, 文
第73回日本体力医学会大会プログラム・予稿集, Sep. 2018

福島県脳卒中発症登録における疾病罹患状況把握のための死亡小票の活用と問題点　　　　　　　　　　　　　　　
中野 裕紀; 梅澤 光政; 大平 哲也; 小橋 元; 弓屋 結; 林 史和; 高橋 秀人
第76回日本公衆衛生学会総会抄録集, 17 Oct. 2017, 日本公衆衛生学会

市区町村別の重度要介護高齢者の在宅日数および関連する地域特性　　　　　　　　　　　　　　　
Oct. 2017

介護レセプトデータを用いた在宅期間の指標化 打ち切りを考慮した検討　　　　　　　　　　　　　　　
Oct. 2017

重度要介護認定者の在宅期間の指標化に向けた全国介護レセプトデータによる予備的検討-入院・入所者および観察期間による打ち切りを中心として-　　　　　　　　　　　　　　　
26 Oct. 2016

全国介護給付費実態調査を用いた訪問診療を3か月以上継続できる要因の研究　　　　　　　　　　　　　　　
26 Oct. 2016

レセプトデータを用いた在宅期間の指標化 -観察期間による打ち切りに関する検討　　　　　　　　　　　　　　　
26 Oct. 2016

介護予防給付の介護費用における効果 ―全国介護レセプトを用いて　　　　　　　　　　　　　　　
26 Oct. 2016

介護レセプトデータを用いた介護評価指標化（要介護度変化、および在宅日数）について　　　　　　　　　　　　　　　
26 Oct. 2016

家族内介護者の冠動脈疾患発症リスク　　　　　　　　　　　　　　　
Oct. 2016

「失われた20年」における職業別男性死亡率とその格差の拡大 1975-2010年の変遷　　　　　　　　　　　　　　　
Oct. 2016

健診発見と臨床発見を考慮した甲状腺がん進展モデルの推定と福島県民健康調査への適用
04 Sep. 2016

成長データの統計解析　　　　　　　　　　　　　　　
Jul. 2016

東日本大震災前後の喫煙状況と自覚症状, 生活習慣病の関連に関する研究ー福島県民健康調査「こころの健康度と生活習慣についての調査」から　　　　　　　　　　　　　　　
04 Nov. 2015

福島県「県民健康調査」データベースの構造について　　　　　　　　　　　　　　　
04 Nov. 2015

東日本大震災に伴う避難生活によるこころの健康度と食生活との関連　　　　　　　　　　　　　　　
04 Nov. 2015

検診発見と臨床症状発見に関する罹患率と有病割合について－潜在時間確率密度のシミュレーションによる検討－
06 Sep. 2015

実践活動をより魅力的に見せるために知っておきたい統計学の作法　　　　　　　　　　　　　　　
Sep. 2015

Change in smoking behavior after a disaster: a study of the evacuees in Fukushima after the great East Japan Earthquake.
The 25th Annual Scientific Meeting of the Japan Epidemiological Association, 23 Jan. 2015

福島県「県民健康調査データ管理システム」について　　　　　　　　　　　　　　　
23 Jan. 2015

The association between living argementant dietry inake among evacuees after the Great East Japan Eaithquake, The Fukushima Health Management Survey
ZHANG, Wen; OHIRA Tetsuya; YUUKI,Michiko; HARIGANE,Mayumi; HORIKOSHI,Naoko; SUZUKI,Yuriko; OTSURU; Akira, YABE; Hirooki; MAEDA; Masaharu, NAGAI; Masato NAKANO; Hironori; TAKAHASHI,Hideto; YASUMURA,Seiji; KAMIYA,Kenji; YAMASHITA,Shunichi; ABE, Masafumi; for the; Fukushima Health; Management; Survey Group
The 25th Annual Scientific Meeting of the Japan Epidemiological Association, 21 Jan. 2015

Ethics statements in original articles published beyond epidemiological journals in Japan.　　　　　　　　　　　　　　　
TAKAHASHI, Hideto; MORIYAMA, Yoko; TAMIYA, Nanako; MA, Enbo
The 25th Annual Scientific Meeting of the Japan Epidemiological Association, 21 Jan. 2015

福祉研究雑誌に掲載された原著等論文における研究倫理の記載について.　　　　　　　　　　　　　　　
29 Nov. 2014

東日本大震災による避難にともなう環境変化と喫煙率に関する報告：県民健康調査から
15 Nov. 2014

東日本大震災における避難区域住民の運動習慣について：福島県県民健康調査.　　　　　　　　　　　　　　　
05 Nov. 2014

介護老人福祉施設における軽度要介護者の入所中止政策に向けて－性別にみた実態把握　　　　　　　　　　　　　　　
05 Nov. 2014

わが国の一人あたり介護サービス利用点数－全国「介護給付費調査」の個票データより－　　　　　　　　　　　　　　　
05 Nov. 2014

通所介護の介護報酬に係る政策と在宅介護サービス利用状況との関連について　　　　　　　　　　　　　　　
05 Nov. 2014

東日本大震災における避難区域住民の運動習慣について：福島県県民健康調査　　　　　　　　　　　　　　　
05 Nov. 2014

Is there common description of ethics in original articles published in welfare?　　　　　　　　　　　　　　　
The 2nd International Conference Center for Grobal Aging Tsukuba preparation Office, 29 Sep. 2014

成長データの統計解析　　　　　　　　　　　　　　　
14 Sep. 2014

福島県「県民健康調査」について.
13 Sep. 2014

福島県「県民健康調査」について
13 Sep. 2014

The cost effectiveness analysis of electrocardiogram.
TAKAHASHI, Hideto; YOSHINAGA, Masao; MA, Enbo
The 20th IEA World Congress of Epidemiology, 18 Aug. 2014, WCE

Screening Program for Prevention of Sudden Cardiac Death in Japan　　　　　　　　　　　　　　　
The 20th IEA World Congress of Epidemiology, 17 Aug. 2014, WCE

A pilot study to explore actual monthly consumption of the people under the Public Livelihood Assistance Program (PLAP) in Japan - A receipt study based on ethics　　　　　　　　　　　　　　　
TAKAHASHI, Hideto
The 1st International Conference on Global Aging Tsukuba, 24 Jan. 2014

ベイズ法を用いた有効性連続データ及び毒性二値データに基づく用量探索アプローチの第Ⅱ相試験への応用　　　　　　　　　　　　　　　
16 Nov. 2013

福祉研究雑誌に掲載された原著等論文における研究倫理の記載について　　　　　　　　　　　　　　　
23 Oct. 2013

WAGATSUMA Yukiko, MA Enbo, ISO Hiroyasu, WAN Xia, FARHANA Ferdousi, TAKAHASHI Hideto, YANG Gonghuan　　　　　　　　　　　　　　　
WAGATSUMA Yukiko, MA Enbo, ISO Hiroyasu, WAN Xia, FARHANA Ferdousi, TAKAHASHI Hideto, YANG Gonghuan
24 Jan. 2013

生活習慣の青少年（15-18歳）の肥満度の変化への関連―全国5高等学校における検討―　　　　　　　　　　　　　　　
24 Jan. 2013

Distortion in representativeness in an epidemiological study in welfare research.　　　　　　　　　　　　　　　
TAKAHASHI HIDETO, WADA ICHIRO, MA EMBO
24 Jan. 2013

福祉疫学研究におけるサンプルの代表制のゆがみについて　　　　　　　　　　　　　　　
24 Oct. 2012

幼少期BMIとその後の経時変化との関連―成長曲線モデルを用いた解析―　　　　　　　　　　　　　　　
26 Jan. 2012

学級閉鎖の有効性と実施後欠席者割合予測―新型インフルエンザ流行時の茨城県T市の小中学校における検討―　　　　　　　　　　　　　　　
26 Jan. 2012

学級閉鎖後の欠席者割合の予測―小学校低学年、高学年、中学校を考慮した検討―　　　　　　　　　　　　　　　
26 Jan. 2012

居宅介護支援事業所の開設法人とケアプランのサービス種類数・総単位数との関連　　　　　　　　　　　　　　　
26 Jan. 2012

介護保険特定施設の利用者数の経年変化と都道府県間の移動に関する研究　　　　　　　　　　　　　　　
26 Jan. 2012

Challenge of epidemiological methodology for welfare study.　　　　　　　　　　　　　　　
2012

肝細胞癌に対する少分割高線量陽子線治療後の放射線起因性肋骨骨折リスク因子解析　　　　　　　　　　　　　　　
2012

Challenge of epidemiological methodology for welfare study.　　　　　　　　　　　　　　　
Human Biology Symposium, The 3rd leading Graduate Schools International Conference, The 7th Tsukuba Medical Science Research Meeting 2012.10.30-11.02, 2012

学級閉鎖実施日数と欠席者減少について―茨城県T市の小学校における検討―　　　　　　　　　　　　　　　
19 Oct. 2011

多変量イベントCox回帰分析の適用に関する考察―サンプルデータを用いた事前検討―　　　　　　　　　　　　　　　
19 Oct. 2011

The impact of school closure during the A/H1N1 epidemic 2009 influenza pandemic among schools in Japan.　　　　　　　　　　　　　　　
A Uda, M Okada, H Takahashi, K Motegi, Y Wagatsuma
IEA World Congress of Epidemiology 7-11 August 2011（国際疫学会世界疫学会議2011）, Aug. 2011

The relationship between the weight in early childhood and the following growth curve in weight.　　　　　　　　　　　　　　　
H Takahashi, T Mikami, M Yoshinaga, M Shinomiya, A Miyazaki
IEA World Congress of Epidemiology 7-11 August 2011（国際疫学会世界疫学会議2011）, Aug. 2011

The relationship of class closure length and the change of absentees at elementary schools in the 2009 A/H1N1 influenza expansion in Japan: the analysis in T city, Ibaraki Prefecture.　　　　　　　　　　　　　　　
S Yamamoto, H Takahashi, I Wada, A Uda, F Irie
IEA World Congress of Epidemiology 7-11 August 2011（国際疫学会世界疫学会議2011）, Aug. 2011

学級閉鎖前後の欠席者数の変化について―茨城県T市H21年9月～12月における経時変化―　　　　　　　　　　　　　　　
21 Jan. 2011

地域在住中～重度要介護高齢者の介護度変化に関連する居宅サービスの利用　　　　　　　　　　　　　　　
2011

久留米大学バイオ統計セミナーにおける講演「クラスターランダム化デザインとその解析―慢性腎臓病悪化予防の戦略研究From-Jより―」　　　　　　　　　　　　　　　
2011

国立社会保障・人口問題研究所「社会保障の給付と財政の在り方に関する研究会」における講演「生活保護者の消費実態―茨城県A自治体におけるレシートを用いた調査（パイロット研究）より―」　　　　　　　　　　　　　　　
2011

Pattern randomness of distant metastasis of primary small cell lung cancer using the conditional probability.　　　　　　　　　　　　　　　
2010

Trends of cancer mortality in Japan, 1950-2004: Age-period-and cohort analysis.　　　　　　　　　　　　　　　
2010

茨城県におけるインフルエンザによる小中、高等学校の学級閉鎖割合の経時的変化　　　　　　　　　　　　　　　
2010

新型インフルエンザ感染動向への数理モデルの適用の試み　　　　　　　　　　　　　　　
2010

国民年金と生活保護に関する実質的受給額の比較に関する研究　　　　　　　　　　　　　　　
2010

平成21年度厚生労働科学研究「がん研究事業」－神経芽腫におけるリスク分類にもとづく標準的治療の確立と均てん化および新規診断・治療法の開発研究－研究成果発表会における講演「臨床試験ってなんですか？」　　　　　　　　　　　　　　　
2010

産業保健研究会4月例会における講演「職場でレセプト分析をどう活用するか？」　　　　　　　　　　　　　　　
2010

Pattern randomness of distant metastasis of primary small cell lung cancer using the conditional probability.　　　　　　　　　　　　　　　
2010

Trends of cancer mortality in Japan, 1950-2004: Age-period-and cohort analysis.　　　　　　　　　　　　　　　
World Cancer Congress 2010（Shenzhen, China）, 2010

WEB生活習慣予防システム導入により見込まれる職域におけるメタボリック関連の削減医療費（外来）の推定　　　　　　　　　　　　　　　
2009

Estimation of Reducible Annual Male Outpatient Medical Expense of the Metabolic Syndrome which Related to Improvement of Health Checkup Result by Health Insurance Offered by Health Insurance Society in Japan　　　　　　　　　　　　　　　
2009

厚生労働省戦略研究「腎疾患重症化予防のための戦略研究（かかりつけ医/非腎臓専門医と腎臓専門医の協力を推進する慢性腎臓病患者の重症化予防のための診断システムの有用性を検討する研究）：From－Ｊ」における統計的諸問題　　　　　　　　　　　　　　　
2009

介護レセプトデータに基づく終末期要介護高齢者のサービス利用、居所変化の実態　　　　　　　　　　　　　　　
2009

Estimation of Reducible Annual Male Outpatient Medical Expense of the Metabolic Syndrome which Related to Improvement of Health Checkup Result by Health Insurance Offered by Health Insurance Society in Japan　　　　　　　　　　　　　　　
The First Asia-Pacific Conference on Health Promotion and Education, 2009

介護保険居宅サービス利用者の施設入所要因-医療行動説明モデルアプローチ　　　　　　　　　　　　　　　
2008

レセプト医療費分解により生じる傷病名別年間外来医療費の差異　　　　　　　　　　　　　　　
2008

在宅介護保険サービス利用者の介護度変化に関連する要因の検証　　　　　　　　　　　　　　　
2008

ITを使った生活習慣病予防プログラムの医療経済評価[第2報]研究デザインとプロセス評価　　　　　　　　　　　　　　　
2008

急速進行性糸球体腎炎の診療指針 2007年における検討　　　　　　　　　　　　　　　
2008

Fridericia補正による小児期のQT延長、QT短縮の基準値の検討　　　　　　　　　　　　　　　
2008

健診結果、生活習慣の差異における年間外来メタボリック関連医療費　　　　　　　　　　　　　　　
2008

職業におけるITを活用した生活習慣病予防プログラムの評価　　　　　　　　　　　　　　　
2008

二段階クラスターランダム化デザインにおけるクラスター効果　　　　　　　　　　　　　　　
2008

The size of distortion in incident rate ratio caused by nodifferential misclassification in cohort study -an approximate expression-　　　　　　　　　　　　　　　
2008

高校生ボランティアにおける心血管（CV）リスクファクタ集積を予測するアディポカインの検討　　　　　　　　　　　　　　　
2008

健診検査値および生活習慣の差異とメタボリック関連年間外来医療費　　　　　　　　　　　　　　　
2008

居住費・食費の自己負担発生前後における介護療養型医療施設から在宅への退所者の比較　　　　　　　　　　　　　　　
2008

要介護高齢者の死亡当月の介護保険サービス利用の実態～某市の全介護レセプト分析から　　　　　　　　　　　　　　　
2008

介護保険居宅サービス利用者の施設入所要因―医療行動説明モデルアプローチ　　　　　　　　　　　　　　　
2008

介護保険居宅サービス利用者の生命予後―主な家族介護者の続柄の違いによる比較―　　　　　　　　　　　　　　　
2008

The size of distortion in incident rate ratio caused by nodifferential misclassification in cohort study -an approximate expression-　　　　　　　　　　　　　　　
XVIII IEA World Congress of Epidemiology, 2008

11ヵ月の介護度変化に関連する要因 某市全レセプトデータから　　　　　　　　　　　　　　　
Oct. 2007

コホート研究において曝露群、対照群内の群誤分類が罹患率比を歪める影響について　　　　　　　　　　　　　　　
2007

わが国の健診における新規検尿異常出現率　　　　　　　　　　　　　　　
2007

小児期、思春期の肥満度頻度の増加と社会的経済成長との関係　　　　　　　　　　　　　　　
2007

コホート研究における要因曝露の誤分類の影響について　　　　　　　　　　　　　　　
2007

介護老人福祉施設の職員配置状況と関連要因 介護サービス施設・事業所調査から　　　　　　　　　　　　　　　
2007

介護老人福祉施設のおむつ使用状況と関連要因 介護サービス施設・事業所調査から　　　　　　　　　　　　　　　
2007

11カ月の介護度変化に関連する要因 某市全レセプトデータから　　　　　　　　　　　　　　　
2007

居住費・食費の見直しによる介護保険施設退所者の移行先 某市全レセプトデータから　　　　　　　　　　　　　　　
2007

「介護サービス施設・事業所調査」による介護老人福祉施設内死亡者の特性の検討　　　　　　　　　　　　　　　
2007

コホート研究において曝露群、対照群内の群誤分類が罹患率比を歪める影響度　　　　　　　　　　　　　　　
2006

居住費・食費の自己負担発生による介護保険3施設への影響 -公表データから　　　　　　　　　　　　　　　
2006

最近話題の統計手法から Poisson Regression Sensitivity Analysis　　　　　　　　　　　　　　　
2006

急速進行性腎炎症候群の臨床的重症度分類　　　　　　　　　　　　　　　
2005

日本人三大死因の年齢-年次-出生コホート解析，1960-2000　　　　　　　　　　　　　　　
2004

悪性新生物死亡構造の46カ国における国際比較　　　　　　　　　　　　　　　
2004

日本人肺炎，不慮の事故による死亡に関する年齢-年次-出生コホート解析，1960-2000　　　　　　　　　　　　　　　
2004

非線形効果に基づく年齢-年次-出生コホート解析における効果の形状の表示について　　　　　　　　　　　　　　　
2004

保健情報提供Webサイトにおける発信情報の評価の試み　　　　　　　　　　　　　　　
2003

日本人女性乳癌死亡における年齢-年次-出生コーホート解析,1960-2000　　　　　　　　　　　　　　　
2003

（奨励賞受賞講演）日本人肺癌死亡の年齢?年次?出生コーホート解析, 1960-1995　　　　　　　　　　　　　　　
2003

開いた集団と閉じた集団における罹患率について　　　　　　　　　　　　　　　
2003

部位別悪性新生物死亡の同時把握による死亡構造の特徴化　　　　　　　　　　　　　　　
2003

遺伝性癌の遺伝子診断に関する意識調査研究　　　　　　　　　　　　　　　
2003

Relationship between Eating Habits and Obesity in Children aged 3 to 6 years old in Ibaraki Prefecture, Japan　　　　　　　　　　　　　　　
2003

健康法の実践とその費用に関する性差, 年齢差　　　　　　　　　　　　　　　
2003

Age-Period-Cohort Analysis of Breast Cancer Mortality in Japan, 1960-1995.　　　　　　　　　　　　　　　
2003

The Feature of Worldwide Mortality from Breast Cancer　　　　　　　　　　　　　　　
2003

異性間性交渉で感染した日本人HIV感染者の感染判明の経緯と判明前の感染兆候について.　　　　　　　　　　　　　　　
2003

乳がん死亡，罹患と経済，健康，医療，検診実施状況との関連について－国際相関研究－　　　　　　　　　　　　　　　
2003

一般成人市民の実践している健康法とその費用に関する調査研究．　　　　　　　　　　　　　　　
2003

Obesity in relation to Daily Breakfast and Snack in Japanese Children.　　　　　　　　　　　　　　　
2003

健康情報Webサイトにおける掲載内容の質的評価の試み．　　　　　　　　　　　　　　　
2003

日本人肺癌死亡の年齢?年次?出生コーホート解析, 1960-1995　　　　　　　　　　　　　　　
2003

Relationship between Eating Habits and Obesity in Children aged 3 to 6 years old in Ibaraki Prefecture, Japan　　　　　　　　　　　　　　　
2003

Age-Period-Cohort Analysis of Breast Cancer Mortality in Japan, 1960-1995.　　　　　　　　　　　　　　　
13th International Congress on the Ultrasonic Examination of the Breast International Breast Ultrasound School, 2003

The Feature of Worldwide Mortality from Breast Cancer　　　　　　　　　　　　　　　
13th International Congress on the Ultrasonic Examination of the Breast International Breast Ultrasound School, 2003

Obesity in relation to Daily Breakfast and Snack in Japanese Children.　　　　　　　　　　　　　　　
2003

標準集団の疾患発生(死亡)数の確率変動を仮定した標準化発生率（死亡）比（SMR）の信頼区間の適用について　　　　　　　　　　　　　　　
2002

CRITERIA OF APPLYING THE ASSUMPTION THAT THE DEATHS IN THE REFERENCE HAVE RANDOM VARIATIONS　　　　　　　　　　　　　　　
2002

DEVELOPMENT OF GLOBAL INTERNET SYSTEM FOR THE PREVENTION OF LIFESTYLE RELATED DISEASES AND DESCRIPTIVE EPIDEMIOLOGY　　　　　　　　　　　　　　　
2002

PUBLIC CONSCIOUSNESS OF GENETIC TESTING FOR FAMILIAL CANCER SUSCEPTIBILITY AND ITS RELATED FACTORS　　　　　　　　　　　　　　　
2002

INTERNATIONAL GEOGRAPHICAL PATTERN OF MORTALITY FROM MALIGNANT NEOPLASM FOR 43 COUNTRIES　　　　　　　　　　　　　　　
2002

標準集団の疾病発生(死亡)数の確率変動を仮定した標準化発生率(死亡)比(SMR)の信頼区間の適用について　　　　　　　　　　　　　　　
2002

52カ国における部位別悪性新生物死亡の地理的構造　　　　　　　　　　　　　　　
2002

CRITERIA OF APPLYING THE ASSUMPTION THAT THE DEATHS IN THE REFERENCE HAVE RANDOM VARIATIONS　　　　　　　　　　　　　　　
The XVI World Congress of Epidemiology of the International Epidemiological Association, 2002

DEVELOPMENT OF GLOBAL INTERNET SYSTEM FOR THE PREVENTION OF LIFESTYLE RELATED DISEASES AND DESCRIPTIVE EPIDEMIOLOGY　　　　　　　　　　　　　　　
The XVI World Congress of Epidemiology of the International Epidemiological Association, 2002

PUBLIC CONSCIOUSNESS OF GENETIC TESTING FOR FAMILIAL CANCER SUSCEPTIBILITY AND ITS RELATED FACTORS　　　　　　　　　　　　　　　
The XVI World Congress of Epidemiology of the International Epidemiological Association, 2002

INTERNATIONAL GEOGRAPHICAL PATTERN OF MORTALITY FROM MALIGNANT NEOPLASM FOR 43 COUNTRIES　　　　　　　　　　　　　　　
The XVI World Congress of Epidemiology of the International Epidemiological Association, 2002

日本人肺癌死亡の年齢-年次-出生コーホート解析　　　　　　　　　　　　　　　
2001

日本人肺癌死亡の年齢, 時代, 出生コーホート効果 -非線形成分を用いた検討-　　　　　　　　　　　　　　　
2001

骨粗鬆症の危険因子としての過度の肥満　　　　　　　　　　　　　　　
2001

Geographical Pattern of Malignant Neoplasm by Cluster Analysis using Standardized Mortality Ratios(SMRs)　　　　　　　　　　　　　　　
2001

Age-Period-Cohort Analysis of Lung Cancer Mortality in Japan, 1960-1995　　　　　　　　　　　　　　　
2001

日本人肺癌死亡の年齢?年次?出生コーホート解析　　　　　　　　　　　　　　　
2001

日本人の食形態を考慮した食物摂取頻度調査票の開発?予備的評価?　　　　　　　　　　　　　　　
2001

社会医学分野における質問紙調査のためのJaveクラスライブラリの構築　　　　　　　　　　　　　　　
2001

Geographical Pattern of Malignant Neoplasm by Cluster Analysis using Standardized Mortality Ratios(SMRs)　　　　　　　　　　　　　　　
The 3rd Asian-Pacific Congress of Epidemiology, 2001

Age-Period-Cohort Analysis of Lung Cancer Mortality in Japan, 1960-1995　　　　　　　　　　　　　　　
The 3rd Asian-Pacific Congress of Epidemiology, 2001

経験的ベイズ法を用いた茨城県女性乳房悪性新生物の標準化発生比(SIR)　　　　　　　　　　　　　　　
2000

期待発生数の確率変動を考慮した茨城県女性乳房悪性新生物の標準化発生比(SIR)の信頼区間　　　　　　　　　　　　　　　
2000

医学生のたばこと健康に関する意識および喫煙の実態調査　　　　　　　　　　　　　　　
2000

標準化死亡比(SMR)を用いた茨城県の部位別悪性新生物死亡のクラスター構造　　　　　　　　　　　　　　　
2000

XMLとJavaによる生活習慣評価システムのフレームワーク　　　　　　　　　　　　　　　
2000

中高年女性の骨粗鬆症に関する共分散構造分析による検討　　　　　　　　　　　　　　　
2000

茨城県における乳癌死亡率の動向に関する検討　　　　　　　　　　　　　　　
1999

茨城県の胆道癌に関する記述疫学的研究　　　　　　　　　　　　　　　
1999

期待死亡数の確率変動を考慮した場合のシミュレーションによる標準化死亡比の信頼区間　　　　　　　　　　　　　　　
1999

期待死亡数の確率変動を考慮した場合のシミュレーションによるSMRの信頼区間　　　　　　　　　　　　　　　
1999

Simulated confidence intervals of standardized mortality ratio when expected death number has a random variation　　　　　　　　　　　　　　　
1999

Geographical trends in breast cancer incidence and mortality in Ibaraki, Japan　　　　　　　　　　　　　　　
1999

Relationship between bone mineral density and obesity　　　　　　　　　　　　　　　
1999

Respiratory symptoms in the elderly-risk appraisal in the Brinkman index　　　　　　　　　　　　　　　
1999

Lifestyle survey over the world wide web　　　　　　　　　　　　　　　
1999

中高年女性における骨粗鬆症の疫学的因果モデル?共分散構造分析による検討?　　　　　　　　　　　　　　　
1999

喫煙高齢者の呼吸器症状?地域住民を対象としたBRINKMAN指数による危険度評価?　　　　　　　　　　　　　　　
1999

食生活と愁訴・行動特性, 医学所見との関連の検討　　　　　　　　　　　　　　　
1999

茨城県の疾病分布のクラスター分析　　　　　　　　　　　　　　　
1999

生活習慣評価機能を持つソフトウェア部品の開発　　　　　　　　　　　　　　　
1999

茨城県における乳癌死亡率と罹患率の現状　　　　　　　　　　　　　　　
1999

Simulated confidence intervals of standardized mortality ratio when expected death number has a random variation　　　　　　　　　　　　　　　
The XV international scientific meeting of the international epidemiological association, 1999

Geographical trends in breast cancer incidence and mortality in Ibaraki, Japan　　　　　　　　　　　　　　　
The XV international scientific meeting of the international epidemiological association, 1999

Relationship between bone mineral density and obesity　　　　　　　　　　　　　　　
The XV international scientific meeting of the international epidemiological association, 1999

Respiratory symptoms in the elderly-risk appraisal in the Brinkman index　　　　　　　　　　　　　　　
The XV international scientific meeting of the international epidemiological association, 1999

Lifestyle survey over the world wide web　　　　　　　　　　　　　　　
The XV international scientific meeting of the international epidemiological association, 1999

Simulation and asymptotic results of influence of D in a D test in a two by two contingency table　　　　　　　　　　　　　　　
1998

Physical activity and risk of breast cancer: A case-control study of Japanese women　　　　　　　　　　　　　　　
1998

高橋秀人　　　　　　　　　　　　　　　
1998

医学における小標本の比率検定について　　　　　　　　　　　　　　　
1998

2×2分割表のΔ検定におけるΔの影響のシミュレーションによる評価　　　　　　　　　　　　　　　
1998

インタ?ネットによる生活習慣調査　　　　　　　　　　　　　　　
1998

標準化死亡比の信頼区間の考察　　　　　　　　　　　　　　　
1998

歩行を中心とした健康増進教室（更年期女性を対象として）　　　　　　　　　　　　　　　
1998

茨城県における乳癌死亡率の地域分布と経年変化　　　　　　　　　　　　　　　
1998

The relationship between eating behavior and neurotic tendencies　　　　　　　　　　　　　　　
1998

JAVA言語による生活習慣評価システムの開発　　　　　　　　　　　　　　　
1998

保健衛生情報の収集と活用?基礎と実際?　　　　　　　　　　　　　　　
1998

Simulation and asymptotic results of influence of D in a D test in a two by two contingency table　　　　　　　　　　　　　　　
The 2nd Asian-Pacific Congress of Epidemiology, 第８回日本疫学会学術総会（共同開催）, 1998

Physical activity and risk of breast cancer: A case-control study of Japanese women　　　　　　　　　　　　　　　
The 2nd Asian-Pacific Congress of Epidemiology, 第８回日本疫学会学術総会（共同開催）, 1998

The relationship between eating behavior and neurotic tendencies　　　　　　　　　　　　　　　
The fifth International Congress of Behavioral Medicine, 1998

出生コ?ホ?トを用いた男性喫煙割合減少による男性肺癌死亡率の減少予測?シミュレ?ション研究?　　　　　　　　　　　　　　　
1997

身体活動と乳癌発生との関連性　　　　　　　　　　　　　　　
1997

乳癌の危険因子の探索　　　　　　　　　　　　　　　
1997

Physical activity and risk of breast cancer: "A case-control study in Ibaraki, Japan"　　　　　　　　　　　　　　　
1997

標準化死亡率の比較に対する考察　　　　　　　　　　　　　　　
1997

健康診断情報を用いた生活習慣診断システム　　　　　　　　　　　　　　　
1997

インタ?ネット利用の生活習慣調査の試み　　　　　　　　　　　　　　　
1997

ハワイ在住日系人と本邦日本人とのBMIの比較研究?ハワイ島ヒロ，オワフ島ハレイワ，茨城県里美の3地域の比較研究?　　　　　　　　　　　　　　　
1997

血液透析患者の食事管理の指標としての血清尿素窒素, リン, カリウムの関連性?自己効力と精神健康を含む患者の背景より?　　　　　　　　　　　　　　　
1997

更年期女性のヘルスプロモ?ションに関する検討?CMIによる各世代間の比較?　　　　　　　　　　　　　　　
1997

Physical activity and risk of breast cancer: "A case-control study in Ibaraki, Japan"　　　　　　　　　　　　　　　
First Meeting of the Asian Breast Cancer Society, 1997

施設老人の転倒の発生頻度と関連要因
15 Oct. 1996

中高年者の健康生活習慣の性差 : 因子構造の解析
15 Oct. 1996

社会医学領域におけるアンケ-ト調査の試み-インタ-ネットの利用-　　　　　　　　　　　　　　　
1996

結核検診未受診者に関する考察-茨城県大宮保健所管内, 大子町宮川地区における調査-
1996

前立腺癌外来治療患者の告知の有無による身体・精神状態の相関構造の差異　　　　　　　　　　　　　　　
1996

Gender Differences In The Lifestyles Of The Middle-Aged And The Elderly　　　　　　　　　　　　　　　
1996

Prediction of a decrease in lung cancer mortality among Japanese males by increasing non-smoker proportions using a simulation model based on birth cohort analysis.　　　　　　　　　　　　　　　
1996

Life style evaluation system to find risk factors in your life style　　　　　　　　　　　　　　　
1996

Incidence of cancer in Ibaraki Prefecture　　　　　　　　　　　　　　　
1996

A study of sex differences in lifestyle towards the primary prevention of cancer　　　　　　　　　　　　　　　
1996

切断正規分布を用いた推薦入学合格者割合の推定　　　　　　　　　　　　　　　
1996

信頼性指標の再確認　　　　　　　　　　　　　　　
1996

施設老人の転倒頻度と転倒要因　　　　　　　　　　　　　　　
1996

地域がん登録システムによる茨城県のがんの罹患状況について　　　　　　　　　　　　　　　
1996

中高年者の健康生活習慣の性差－因子構造の解析－　　　　　　　　　　　　　　　
1996

ハワイ在住日系人の健康に関連した生活習慣について－ハワイ島ヒロ市における調査－　　　　　　　　　　　　　　　
1996

推薦入学合格者割合の推定について　　　　　　　　　　　　　　　
1996

Gender Differences In The Lifestyles Of The Middle-Aged And The Elderly　　　　　　　　　　　　　　　
The Teaching to Promote Women's Health: International Multidisciplinary Conference, 1996

Prediction of a decrease in lung cancer mortality among Japanese males by increasing non-smoker proportions using a simulation model based on birth cohort analysis.　　　　　　　　　　　　　　　
International Epidemiological Association XIVth International Scientific Meeting, 1996

Life style evaluation system to find risk factors in your life style　　　　　　　　　　　　　　　
International Epidemiological Association XIVth International Scientific Meeting, 1996

Incidence of cancer in Ibaraki Prefecture　　　　　　　　　　　　　　　
International Epidemiological Association XIVth International Scientific Meeting, 1996

A study of sex differences in lifestyle towards the primary prevention of cancer　　　　　　　　　　　　　　　
International Epidemiological Association XIVth International Scientific Meeting, 1996

がん登録データを用いた検診評価の一考察
15 Oct. 1995

調査の方法論 : インターネットを利用したアンケート調査の試み
15 Oct. 1995

New Trial of Investigation Methodology : Making Use of Internet
15 Mar. 1995

出生コーホートに基づいた肺がんのハザードの推定に関する基礎的研究　　　　　　　　　　　　　　　
1995

インターネット利用アンケート調査におけるプライバシー保護に関する一考察　　　　　　　　　　　　　　　
1995

調査の方法論の新しい試み－インターネットを利用して－　　　　　　　　　　　　　　　
1995

A Study of the System Development Evaluating Life Style to Prevent the Non-infections Chronic Diseases Based on the Epidemiological Data　　　　　　　　　　　　　　　
1995

Sex Difference of Lifestyle Related to Health in a Rural Area　　　　　　　　　　　　　　　
1995

調査の方法論－インターネットを用いたアンケート調査の試み－　　　　　　　　　　　　　　　
1995

ハワイ日系人中高年者の癌予防に関連した生活習慣についての調査研究　　　　　　　　　　　　　　　
1995

A Study on Prediction of Hazard of Male Lung Cancer Based on Birth Cohort Analysis in Japan　　　　　　　　　　　　　　　
1995

A Study of the System Development Evaluating Life Style to Prevent the Non-infections Chronic Diseases Based on the Epidemiological Data　　　　　　　　　　　　　　　
The XVth World Conference of the International Union for Health Promotion and Education, 1995

Sex Difference of Lifestyle Related to Health in a Rural Area　　　　　　　　　　　　　　　
The XVth World Conference of the International Union for Health Promotion and Education, 1995

A Study on Prediction of Hazard of Male Lung Cancer Based on Birth Cohort Analysis in Japan　　　　　　　　　　　　　　　
Shanghai International Epidemiological Association Congress, 1995

正規分布からの第２種打切り標本における平均の最尤推定量の２次のバイアス　　　　　　　　　　　　　　　
1994

出生コ?ホ?トに基づいた肺がんの瞬間死亡率（ハザ?ド）の予測に関する研究　　　　　　　　　　　　　　　
1994

最良近似多項式を用いた平均寿命の予測に関する研究　　　　　　　　　　　　　　　
1994

健康に関連した生活習慣調査票の作成とその評価　　　　　　　　　　　　　　　
1994

茨城県における地域健康情報システムの現状と課題　　　　　　　　　　　　　　　
1994

茨城県におけるがんの罹患数及び届出精度　　　　　　　　　　　　　　　
1994

ハワイ日系人の健康生活習慣に関する調査研究　　　　　　　　　　　　　　　
1994

Gender Differences In The Lifestyles Of The Middle-Aged And The Elderly　　　　　　　　　　　　　　　
1993

国保レセプト統計を用いたスギ花粉症受診率の変動分析　　　　　　　　　　　　　　　
1993

Gender Differences In The Lifestyles Of The Middle-Aged And The Elderly　　　　　　　　　　　　　　　
The Teaching to Promote Women's Health: International Multidisciplinary Conference, 1993

Type II Censored Normal Sample におけるM.L.E. の２次のBias Reduction について　　　　　　　　　　　　　　　
1992

茨城県におけるアレルギー鼻炎の11年間の推移と地理的分布 ?国保レセプトデータの解析?　　　　　　　　　　　　　　　
1992

Order of Convergence of Fisher Information for Type II Censored Sample　　　　　　　　　　　　　　　
1988

Error Bound of the Fisher Information for Type II Censored Sample from Normal Population　　　　　　　　　　　　　　　
1988

Order of Convergence of Fisher Information for Multiparameters from Type II Censored Sample　　　　　　　　　　　　　　　
1988

Order of Convergence of Fisher Information for Type II Censored Sample　　　　　　　　　　　　　　　
1988

Error Bound of the Fisher Information for Type II Censored Sample from Normal Population　　　　　　　　　　　　　　　
1988

Order of Convergence of Fisher Information for Multiparameters from Type II Censored Sample　　　　　　　　　　　　　　　
1988

Apr. 2025 - Present
Japanese Association for Pharmaceutical Education　　　　　　　　　　　　　　　

Apr. 1996 - Present
International Epidemiological Association : IEA　　　　　　　　　　　　　　　

Apr. 1996 - Present
International Epidemiological Association　　　　　　　　　　　　　　　

Mar. 1994 - Present
日本疫学会　　　　　　　　　　　　　　　

Nov. 1992 - Present
日本公衆衛生学会　　　　　　　　　　　　　　　

Apr. 1992 - Present
International Biometiric Society : IBS　　　　　　　　　　　　　　　

Apr. 1992 - Present
International Biometiric Society　　　　　　　　　　　　　　　

Jun. 1988 - Present
日本統計学会　　　　　　　　　　　　　　　

Statistics by Looking at Data　　　　　　　　　　　　　　　
Hideto Takahashi
Apr. 2022 - Mar. 2024, Educational materials

Statistical Analyses with EZR　　　　　　　　　　　　　　　
Hideto TAKAHASHI
Apr. 2022 - Mar. 2024, Educational materials

Statistical Analysis Using SAS (Enterprise Guide 7.1)　　　　　　　　　　　　　　　
Hideto Takahashi
Sep. 2021 - Mar. 2024, Educational materials

Introduction to Major Statistical Software and Practical Data Analysis　　　　　　　　　　　　　　　
Hideto TAKAHASHI
Apr. 2020 - Mar. 2024, Educational materials

Statistical Analysis Using RStudio　　　　　　　　　　　　　　　
Hideto Takahashi
Apr. 2020 - Mar. 2024, Educational materials

Statistical Training for Promoting the PDCA Cycle　　　　　　　　　　　　　　　
Hideto Takahashi
Dec. 2019 - Mar. 2024, Educational materials

Statistical Analysis Using Excel　　　　　　　　　　　　　　　
Hideto TAKAHASHI
Sep. 2019 - Mar. 2024, Educational materials

Statistics for Evidence-Based Policy Making　　　　　　　　　　　　　　　
Hideto TAKAHASHI
Sep. 2018 - Mar. 2024, Educational materials

Analysis of NDB Open Data　　　　　　　　　　　　　　　
Hideto TAKAHASHI
Mar. 2024, Educational materials

Statistical Analysis Using SPSS　　　　　　　　　　　　　　　
Hideto TAKAHASHI
Sep. 2019 - Feb. 2024, Educational materials

Development of the Japanese version of ASCOT-Proxy measuring social care-related QoL and application to the evaluation of community-based integrated care system in Japan
Grant-in-Aid for Scientific Research (B)
National Institute of Public Health
Apr. 2025 - Mar. 2029

A Study on the Development of a Machine Learning–Based System to Support the Certification Review Process in Long-Term Care Needs Assessment Committees　　　　　　　　　　　　　　　
Teikyo Heisei University
Apr. 2025 - Mar. 2028

A Study on the Development of a Machine Learning–Based System to Support the Certification Review Process in Long-Term Care Needs Assessment Committees　　　　　　　　　　　　　　　
Teikyo Heisei University
Apr. 2025 - Mar. 2027

薬学部学生との地域住民交流によるセルフメディケーション意識向上の評価に関する研究
Jul. 2025 - Mar. 2026

A Study on the Development of a Machine Learning–Based System to Support the Certification Review Process in Long-Term Care Needs Assessment Committees　　　　　　　　　　　　　　　
Teikyo Heisei University
Apr. 2023 - Mar. 2026

職域におけるHIV感染症に関する知識の普及啓発の促進に向けた研究
Apr. 2023 - Mar. 2026

Research aimed at improving Japan's cause of death and disease statistics through the application of ICD-11
Apr. 2023 - Mar. 2026

Development of a comprehensive support program for caregivers in their 40s and 50s to improve their happiness in caregiving, childcare, and work
Grant-in-Aid for Scientific Research (B)
National Institute of Public Health
Apr. 2021 - Mar. 2025

Research to establish sustainable indicators that contribute to the evaluation of the dental care delivery system utilizing NDB.　　　　　　　　　　　　　　　
Kyoto Prefectural University of Medicine
Apr. 2022 - Mar. 2024

ICFに基づく利用者のwell-being測定による福祉施設アウトカム評価の研究
Apr. 2021 - Mar. 2024

“Development of a Machine Learning–Based System to Support the Process of Long-Term Care Certification Review”　　　　　　　　　　　　　　　
Apr. 2020 - Mar. 2023

Development of Service Profit Chain for improvement of well-being at long-term care feild
Grant-in-Aid for Challenging Research (Exploratory)
National Institute of Public Health
Jun. 2018 - Mar. 2023

職域での健診機会を利用した検査機会拡大のための新たなHIV検査体制の構築に向けた研究
2020 - 2022

地域包括ケアシステムにおいて活用可能な国際生活機能分類（ICF）による多領域にまたがる評価手法の確立に資する研究　　　　　　　　　　　　　　　
Apr. 2020 - Mar. 2021

A simulation modelling study to examine the effects of underlying factors and control measures on disease incidence and mortality in a population
Grant-in-Aid for Scientific Research (B)
National Cancer Center Japan
Apr. 2017 - Mar. 2021
We developed simulation models for cancer incidence and mortality and conducted population-based analysis on preventive/risk factors in Japan. For stomach cancer, we elucidated an optimal condition of endoscopic cancer screening. For colorectal cancer, we quantified the effect in mortality reduction of realizing the national goal of screening: 50% participation rate and 90% detailed examination rate. For hepatocellular carcinoma, we revealed the effect of the ongoing national programs for hepatitis control in the number of carriers and deaths by hepatocellular carcinoma. For prostate cancer, we found an evident increase in localized cases without any clear decrease in distant cases or mortality. For prevention/risk factors, we estimated the effect of comprehensive tobacco control policies on mortality reduction, and the national prevalence of human papilloma virus by genotype. These findings are useful to implement evidence-based cancer controls in Japan.

難治性疾患等を対象とする持続可能で効率的な医療の提供を実現するための医療経済評価の手法に関する研究　　　　　　　　　　　　　　　
Oct. 2017 - Mar. 2020

加熱式たばこなど新たなたばこ製品の成分分析と受動喫煙による健康影響の評価手法の開発　　　　　　　　　　　　　　　
2018 - 2020

Empirical Research on the Effects of Lifestyle-Related Disease Prevention on Labor Productivity and Macroeconomics from the Perspective of Cost-Effectiveness Analysis　　　　　　　　　　　　　　　
Health Labour Sciences Research Grant・Comprehensive Research on Measures against Cardiovascular Diseases, Diabetes, and Other Lifestyle-Related Diseases
Waseda University
Apr. 2017 - Mar. 2019

病院勤務医の勤務実態に関する研究　　　　　　　　　　　　　　　
2018 - 2019

職域での健診機会を利用した検査機会拡大のための新たなHIV検査体制の研究
2017 - 2019

職域での健診機会を利用した検査機会拡大のための新たなHIV検査体制の研究
2017 - 2019

Validation of Linkage Methods and Logic Development for Medical and Long-Term Care Information, and Analysis of Regional Variations in Medical and Long-Term Care　　　　　　　　　　　　　　　
National Institute of Public Health
Apr. 2017 - Mar. 2018

Study for representativeness and maintenance of Comprehensive Survey of Living Conditions and Survey of Long-term Care Benefit Expenditures
Grant-in-Aid for Scientific Research (C)
Oct. 2015 - Mar. 2018
For Comprehensive Survey of Living Conditions (CSLC), large-scale survey every three years and Small-scale survey in each interim year of Large-scale survey year, survey districts were reviewed to National Census every 5 years. The size of survey districts was around 50 households and inflation factor amplified estimation error. So the influence on the results of movement of young people and single-household cannot be ignored.
For Survey of Long-term Care Benefit Expenditures (SLCBE), data are provided the set which consist of basic information (H1), collective information (T1), detailed information (D1), cost plan for household services (D5), Recipient ledger (M). We extracted the data on a monthly basis by managing them with the structure, individual × the number of applied facilities ×months (H1), the kind of service × the number of applied facilities × months (T1), (service id) × the number of applied facilities × months (D1), individual × months (M).

Multi-disciplinary study on the long-term and medical care that promote satisfaction at the end of life
Grant-in-Aid for Scientific Research (B)
University of Tsukuba
Jul. 2014 - Mar. 2017
To provide the foundation for a system where anyone can have achieve satisfaction at the end of life, we performed a multi-disciplinary study on long-term and medical care in Japan.
The contents included; a review of end-of-life care and guidelines. Empirical studies consisted of: 1) A survey of medical records of older patients transferrd from institutional care to ambulance care, and the situation and prognosis of artificial nutrition in Japan. 2) A Long-term care survey, including a patient record survey of the decision-making process among families and the elderly, a survey of bereaved family members, and careworkers. Special focus was given to the meaning of bathing after death, as offered in institutional care.
In conlusion, from the evidence that we gathered; devising and implementing a system to encourage explanation and discussion with older people and their families, and the provision of more rich care to provide satisfaction at the end of life are needed.

乳幼児突然死症候群（SIDS）および乳幼児突発性危急事態（ALTE）の病態解明等と死亡数減少のための研究　　　　　　　　　　　　　　　
2014 - 2016

The Implementation of Regional Comprehensive Care through Field-based Health Services Research: The integration of Welfare, Medical and long-term Care
Grant-in-Aid for Scientific Research (A)
University of Tsukuba
Apr. 2012 - Mar. 2015
This study is aimed at implementing the PDCA cycle (process improvement technique consisting of 4 steps:Plan,Do,Check, and Act) which has two main components, medical, long term care, and welfare care fieldsites and the university. We have planned to cooperate with the medical, long term care, welfare fieldsites by examining together the Tsukuba-city medical welfare case examination meetings, and providing feedback to Tsukuba City by analyzing their needs survey. We performed a scientific study using several types of data analysis, including big data from national long-term care benefit expenditures data and from the Comprehensive Survey of Living Conditions. We examined the regional comprehensive care promotion policy , including these findings, to clarify how to advance the cooperation between medical and long-term care, what kind of support require the persons in need of care, children with disabilities and the use situation of nursing care insurance services.

Theories and Methodologies for High-Dimensional Data Analysis
Grant-in-Aid for Scientific Research (B)
University of Tsukuba
Apr. 2010 - Mar. 2015
We created two high-dimensional PCAs which we called the noise-reduction methodology and cross-data-matrix methodology. We proposed a new model, the power spiked model, for eigenvalues and gave consistent estimators of the eigenvalues, eigenvectors and PC scores. We did pioneering work on band-width confidence regions, two-sample problems, classification, variable selection, regression, pathway analysis and so on. We created the extended cross-data-matrix methodology which gives an unbiased estimator at low cost and applied it to the test of correlations. We considered multiclass discriminant analysis and showed that the distance-based classifier, geometric classifier and feature selection by DQDA are superior to sparse regularized classifiers. We proved their misclassification rates go to zero in high-dimension, non-sparse settings. Our work can be applied to many fields, such as medicine and big data, and has much lower computational costs with higher accuracy than existing methods.

小児がん拠点病院を活用した臨床研究基盤のあり方及び新規治療開発に関する研究　　　　　　　　　　　　　　　
2013

For a peaceful epilogue of life : An integrated outcome research center based on public health, forensic medicine and law
Grant-in-Aid for Scientific Research (B)
University of Tsukuba
2009 - 2011
A peaceful epilogue to our lives is what every human-being desire.
However, in our rapid-aging country, there are many cases in which it cannot beaccomplished, such as in the case of a solitary death, by being abused, anaccident, or difficulty in dying at home. In this research, the actual conditions of these avoidable deaths in our country were explored by means of an interdisciplinary research with a health service research, and forensic medicine and a legal viewpoint.
As a result, the community mutually supports itself based on an understanding of the dementia or psychiatric disorders, and a safe environmental management (the safety of farm machines etc) of the area. It was suggested that the medical welfare network in the community, such as the improvement of the role of the home support clinics or the end-of life care in the facilities, was very important.

福祉・介護サービスの質向上のためのアウトカム評価拠点－実態評価から改善へのＰＤＣＡサイクルの実現　　　　　　　　　　　　　　　
2009 - 2011

MATHEMATICAL STATISTICS FOR DATA ANALYSIS IN HIGH DIMENSION, LOW SAMPLE SIZE CONTEXT AND ITS APPLICATIONS
Grant-in-Aid for Scientific Research (B)
University of Tsukuba
2006 - 2009
We developed the high-dimension asymptotic theory for High Dimension, Low Sample Size (HDLSS) datasets under a general setup such as non-Gaussian distributions. We found several geometric structures of HDLSS datasets. We showed that the naive PCA is inconsistent in the HDLSS context. We proposed effective inference methods called (1) the noise-reduction methodology, and (2) the cross-data-matrix methodology. By using those methodologies, we gave consistent estimation for intrinsic dimensionality, eigenvalues, their limiting distributions, PC directions and PC scores in the HDLSS context. We applied those methodologies to the discriminant analysis and the cluster analysis in HDLSS data situations from a microarray study of prostate cancer.

代替療法の実態に関する社会調査研究
2003 - 2003

Cost Effectiveness Analysis of influenza vaccination for people aged 65 or older in Japan
Grant-in-Aid for Scientific Research (C)
TSUKUBA UNIVERSITY
2002 - 2003
Epidemics of influenza break out annually throughout the world, although their extent and severity vary widely. Recurring epidemics are known to have consequences such as morbidity that disrupts work in school, company, and elsewhere. Although influenza affects entire population, individuals, such as persons aged 65 years and over, or persons with pre-existing disease are at higher risk of becoming serious enough to be hospitalized or die. The number of those individuals is increasing in developed countries, as the aging of population progresses. Consequently, they confront with the problem of serious morbidity and mortality from influenza.
Japan launched a government-founded age-base national influenza immunization program in December 2001. Under this program, every person aged 65 and over is entitled to a subsidy for influenza vaccination. One-dose of vaccination administrated to a voluntary vaccinee in the target population will be paid partially by public expenditure.
Studies have reported that age-base influenza vaccination program to those aged 65 years or older to be cost-saving or cost-effective in some countries or regions, but cost-effectiveness of the current immunization program in Japan has not been reported. In this study we performed an economic evaluation to investigate the following two questions in detail. A) Is the current subsidy strategy efficient? B) Is there any alternative strategy of immunization which could be more efficient?
A decision-analytic model was constructed to investigate the cost and effectiveness of two age-base immunization programs and two risk-base immunization programs. Accompanied by a series of sensitivity analyses and Monte Carlo simulation our study demonstrates that from the perspective of society, 1) current influenza vaccination program for people aged 65 and over in Japan is cost-effective from the perspective of society (US$6, 282/YOLS in base case), 2) risk-base strategy has favorable incremental cost-effective ratios than age-base strategy ; however, both of risk-base and age-base immunization strategies are reasonably cost-effective.

地域における長期的な循環器疾患予防対策が高齢者のADL、QOLおよび医療費に及ぼす影響　　　　　　　　　　　　　　　
2001 - 2003

地域における長期的な循環器疾患予防対策が高齢者のADL、QOLおよび医療費に及ぼす影響　　　　　　　　　　　　　　　
2001 - 2003

南西アジアと日本に於けるヒト胆道癌の発生・進展に関する遺伝子癌生物学的研究
1997 - 1999

Epidemiological Research Based on the Thyroid Examination Results of the Fukushima Health Management Survey: From Fundamentals to Practical Interpretation　　　　　　　　　　　　　　　
Study Meeting on the Thyroid Examination Results of the Fukushima Health Management Survey, Organized by the Nuclear Regulation Authority, Feb. 2020

Developing Social Statistics in Japan for the Advancement of Welfare Epidemiology: An ICF-Based Perspective　　　　　　　　　　　　　　　
Feb. 2020

The Emerging Role of Biostatistics in the Future of Public Health　　　　　　　　　　　　　　　
Juntendo University Symposium, Dec. 2019

Reported domestic research findings on the International Classification of Functioning, Disability and Health (ICF) at the 19th Expert Committee on the Classification of Functioning, Subcommittee on Statistics, Social Security Council.　　　　　　　　　　　　　　　
Ministry of Health, Labour and Welfare (MHLW), Japan, 14 Mar. 2019

The ICF and Social Statistics: Mapping to the 'Survey on Difficulties in Living　　　　　　　　　　　　　　　
International Exchange Seminar in Public Health and Human Care, Feb. 2019

Structure of the Fukushima Prefecture 'Fukushima Health Management Survey' Database and Data Provision　　　　　　　　　　　　　　　
Fukushima Medical Society, The 451st Academic Research Meeting, Jun. 2015

On the Selection of Statistical Methods Used in Research and the Required Content for Presentations　　　　　　　　　　　　　　　
Apr. 2012

Public Health Challenges and Opportunities through Global Linkage of Knowledge and Experience　　　　　　　　　　　　　　　
The 3rd Leading Graduate School International Conference, The 3rd Leading Graduate School International Conference 2012, Public Health Session,, Apr. 2012

Cluster Randomized Design and Its Analysis: From the From-J Study on Strategies to Prevent Progression of Chronic Kidney Disease　　　　　　　　　　　　　　　
Hideto TAKAHASHI, Hideto TAKAHASHI, Mar. 2011

Consumption Patterns of Public Assistance Recipients: Findings from a Receipt-Based Survey in Municipality A, Ibaraki Prefecture (Pilot Study)　　　　　　　　　　　　　　　
2011

What is a clinical trial?　　　　　　　　　　　　　　　
Establishment and Standardization of Risk Classification–Based Standard Therapies for Neuroblastoma, and Research on the Development of Novel Diagnostic and Therapeutic Methods, Nov. 2010

Applications of Claims Data Analysis in Occupational Health Settings　　　　　　　　　　　　　　　
Apr. 2010

Recent Statistical Methods: Poisson Regression and Sensitivity Analysis　　　　　　　　　　　　　　　
Jan. 2006

Fundamentals of Information Management　　　　　　　　　　　　　　　
Aug. 2003

Statistics for Prevention　　　　　　　　　　　　　　　
Feb. 2001

From Databases to Medical Research　　　　　　　　　　　　　　　
Feb. 2001

Statistics in Medicine: Between Practice and Theory　　　　　　　　　　　　　　　
2001

Collection and Utilization of Public Health Information: Fundamentals and Practice　　　　　　　　　　　　　　　
Feb. 1998

In-Depth Look at Pharmacy Students’ Community Support Initiatives — Attracting Site Visits from Drugstores and Pharmacy Chains
Mutual Learning, Mutual Support, Mutual Protection — and AI, 24 Sep. 2025, Paper

No Significant Association between Radiation Exposure and Thyroid Cancer　　　　　　　　　　　　　　　
Fukushima Minpo, 11 Oct. 2024, Paper

Peer Review　　　　　　　　　　　　　　　
Apr. 1994 - Present

Statistical Consultation　　　　　　　　　　　　　　　
Feb. 1994 - Present

Conducted an Intensive Seminar on How to Write Research Papers　　　　　　　　　　　　　　　
Japan Public Health Association (JPHA), 1999 - 2023