Tatsuya Hisajima
| Faculty of Health Care,Department of Acupuncture and Moxibustion | Professor |
| Graduate School of Health Sciences,Doctoral Program in Health Sciences | Professor |
| Graduate School of Health Sciences,Master's and Doctoral Programs in Acupuncture and Moxibustion | Professor |
Last Updated :2026/10/02
■Researcher basic information
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Career
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Paper
- Electrochemical viscosity correction for robust salivary ionomics via redox probe voltammetry
Hironori Myochin; Romanas Chaleckis; Tadaharu Ueda; Miguel Gonzálvez Noguera; Jie Zhang; Noriyasu Ohshima; Takashi Izumi; Tatsuya Hisajima; Mikaru Mori; Tomoya Kimura; Masanobu Mori
Talanta, Nov. 2026, [Reviewed] - Capillary electrophoresis using triple layer modified capillary facilitating salivary ion analyses: Application to search for potential stress markers induced by cold pressure test
Hironori Myochin; Noriyasu Ohshima; Takashi Izumi; Tatsuya Hisajima; Romanas Chaleckis; Masanobu Mori
Journal of Chromatography A, Apr. 2024, [Reviewed] - Clinical effect of phytosterol-enriched saw palmetto extract on urinary function in healthy middle-aged and older males: a double-blind, placebo-controlled randomized comparative study
Tatsuya Hisajima; Hideaki Waki; Takuya Suzuki; Takashi Izumi
Functional Foods in Health and Disease, 09 Feb. 2024, [Reviewed]
Background: Saw palmetto extract (SPE) is one of the most widely used supplements for benign prostatic hyperplasia (BPH) due to its pharmacological effects. β-sitosterol-enriched saw palmetto oil (VISPO™) contains more than 3% β-sitosterol and 85% total fatty acids and has been shown to improve symptoms in patients with BPH. Lower urinary tract symptoms (LUTS) require primary preventive measures in countries with accelerated population aging, including Japan. VISPO™ is expected to be effective against the early symptoms of LUTS. However, the effect of VISPO™ on urinary function in healthy individuals has not been elucidated.Objective: This clinical study evaluated the efficacy and tolerability of VISPO™ in the management of urinary complaints among healthy middle-aged and older men who did not require treatment.Methods: We conducted a randomized, double-blind, placebo-controlled trial that included 54 male participants who were assigned to consume VISPO™ or placebo (olive oil) capsules for 12 weeks. Biometric data, uroflowmetry results, and salivary hormone levels were assessed at weeks 1 and 12. Urinary function and quality of life were assessed at weeks 1, 4, 8, and 12 using the International Prostate Symptom Score (IPSS), Overactive Bladder Symptom Score (OABSS), Core Lower Urinary Tract Symptom Score (CLSS), and WHOQOL-26.Results: Two-way analysis of variance revealed that IPSS and OABSS were significantly lower in the VISPO™ group that in the placebo group. However, there were no significant differences in urine volume, urinary flow rate, or salivary hormone levels. In addition, no participants reported adverse effects (diarrhea, abdominal pain, etc.). Conclusion: The results of the present study, which is the first randomized controlled trial of VISPO™ conducted among healthy participants, demonstrate the effectiveness of VISPO™ in the management of lower urinary tract complaints that do not require treatment. Trial Registration: University Hospital Medical Information Network Clinical Trials Registry (UMIN000046386).Keywords: saw palmetto, VISPO™, β-sitosterol, fatty acids, healthy subjects, primary preventive, IPSS, OABSS, lower urinary tract symptoms (LUTS) - Effect of transcutaneous vagus nerve stimulation on daytime sleepiness, depression, and study engagement in college students: a randomized controlled trial
Hideaki Waki; Takuya Suzuki; Yoichi Minakawa; Naruto Yoshida; Shogo Miyazaki; Tatsuya Hisajima
VULNERABLE CHILDREN AND YOUTH STUDIES, Mar. 2023, [Reviewed] - Acupuncture Relaxation, Vigilance Stage, and Autonomic Nervous System Function: A Comparative Study of Their Interrelationships.
Chikako Uchida; Hideaki Waki; Yoichi Minakawa; Hideaki Tamai; Shogo Miyazaki; Tatsuya Hisajima; Kenji Imai
Medical acupuncture, 01 Aug. 2020, [Reviewed]
Objective: During acupuncture stimulation, autonomic nervous system (ANS) function changes toward being parasympathetic-dominant, with a transient decrease in heart rate (HR). The aim of this research was to determine the relationships between cortical relaxation and vigilance as observed on background electroencephalograms (EEGs), HR, and ANS function during deep acupuncture. Materials and Methods: This comparative study was conducted at Teikyo Heisei University, in Toshima-ku, Tokyo, Japan, with 27 healthy male volunteers. After resting for 20 minutes, the men received manual acupuncture at LI 10 on the left forearm for 2 minutes at a depth of 15-20 mm at a 1-Hz frequency while undergoing concurrent EEG and electrocardiography (ECG) monitoring. Each subject described his level of comfort during acupuncture. HR; power ratios (normalized units [n.u.]) of EEG alpha, beta, delta, and theta waves; and HR variability (HRV) indices were calculated. Results: In the subgroup who experienced discomfort, delta and theta n.u. were decreased while alpha n.u. were increased, indicating increased vigilance and decreased relaxation. In the subgroup who experienced comfort, there were no significant changes. HRV indices suggested parasympathetic-dominant changes in both subgroups. Weak correlations were observed between a decrease of theta n.u. and sympathetic-dominant changes in HRV indices. Conclusions: Alterations in background EEG activities were not the primary factors changing ANS function to parasympathetic-dominant and decreasing HR, but these alterations related to a weak secondary factor changing ANS function. EEG activity by which cortical relaxation and vigilance were represented was the weak secondary factor changing ANS function during acupuncture; the primary factor might be supraspinal reflection. - Electroacupuncture of the Ophthalmic Branch of the Trigeminal Nerve: Effects on Prefrontal Cortex Blood Flow.
Takuya Suzuki; Hideaki Waki; Kenji Imai; Tatsuya Hisajima
Medical acupuncture, 01 Jun. 2020, [Reviewed]
Objective: The current authors observed enhanced cerebral blood flow (CBF) in the prefrontal cortex (PFC) in response to 100-Hz electroacupuncture (EA) stimulation of the ophthalmic branch of the trigeminal nerve. However, it is not yet clear if responsiveness to 100-Hz EA depends on stimulus intensity. This study examined the effects of stimulus strength on PFC CBF during 100-Hz EA of the ophthalmic branch of the trigeminal nerve. Materials and Methods: Twelve subjects underwent 3 acupuncture sessions: I, control, no stimulation; II, 0.1 mA EA; and III, 0.2 mA EA). Needles were inserted 1 cm lateral of the head median line; the anterior insertion point was on the front hairline and the posterior insertion point was ∼7 cm behind the hairline. Stimulation frequency was set to 100-Hz. PFC CBF was measured in terms of oxygenated, deoxygenated, and total hemoglobin (OxyHb, DeoxyHb, TotalHb, respectively), using 16-channel (Ch) near-infrared spectroscopy. Results: Stimulation of 0.2 mA was associated with significant elevation of OxyHb levels in the 0.1 mA condition in Chs 6, 10, and 12. Ch 2-6, 10, 12 signals were notably higher than in the control condition. Stimulation of 0.2 mA and 0.1 mA were associated with significant declines in DeoxyHb levels, compared to the control condition in Ch 4. Finally, 0.2 mA stimulation in Chs 12 and 13 was associated with significant elevation of TotalHb levels in the control condition. Conclusions: Using 0.2-mA stimulation, 100-Hz EA of the ophthalmic nerve enhances PFC CBF more strongly than 0.1-mA stimulation. - Effects of Cathode Direct-Current Electroacupuncture Stimulus of the Promixal Anterior Lower Limbs on Heart Rate and Lumbar Blood Flow
Kiyoshi Tamai; Kenji Imai; Tatsuya Hisajima
Medical Acupuncture, 01 Apr. 2020, [Reviewed] - Effects of a Standardized Oligomerized-Polyphenol from Litchi chinensis Fruit Extract and Mixed Plant Extract Supplementation on Peripheral Circulation and Cold Sensitivity.
Hideaki Waki; Takuya Suzuki; Kazuo Uebaba; Tatsuya Hisajima
Journal of nutritional science and vitaminology, 2020
Certain individuals tend to suffer from a cold sensation-particularly in the lower extremities-despite most people not suffering from the same sensation. In Japan, this phenomenon is called "hie-sho" and reduces quality of life for several people, particularly women. A previous study has shown that a standardized oligomerized-polyphenol from Litchi chinensis fruit extract (OPLFE) reportedly causes a significant increase in body surface temperature. The present study aimed to investigate whether supplementation with OPLFE affected peripheral circulation and cold sensitivity. This randomized, double-blind, placebo-controlled trial was performed including 25 participants (age, 45.0±10.4 y; 3 males and 22 females) who were assigned to consume OPLFE, mixed plant extract with OPLFE, or placebo capsules for 14 d. Participants were instructed to relax for 60 min in a temperature-controlled room prior to obtaining measurements. Changes in skin temperature and peripheral blood flow of the middle finger were assessed immediately before and 1, 5, 10, 20, and 30 min after immersion in cold water (10ºC). Participants' height, weight, skin temperature, and blood flow in peripheral tissue were measured; furthermore, their "hie-sho" was measured using the Visual Analog Scale (VAS). Skin temperature and blood flow in peripheral tissue increased in the OPLFE and mixed plant extract with OPLFE groups on day 14 compared with those on day 1. In addition, cold sensitivity in these two groups significantly improved between day 1 and day 14. These findings suggest that OPLFE improves "hie-sho" by increasing peripheral blood flow and skin temperature. - Effects of stimulus strength on prefrontal cortex blood flow during 100-Hz electroacupuncture of the ophthalmic branch of the trigeminal nerve. (submitted)
HISAJIMA Tatsuya
Acupunct Med, Dec. 2019, [Reviewed] - Effects of Acupuncture Sensations on Transient Heart Rate Reduction and Autonomic Nervous System Function During Acupuncture Stimulation
Chikako Uchida; Hideaki Waki; Yoichi Minakawa; Hideaki Tamai; Shogo Miyazaki; Tatsuya Hisajima; Kenji Imai
Medical Acupuncture, Jun. 2019, [Reviewed] - Evaluation of Autonomic Nervous System Function Using Heart Rate Variability Analysis during Transient Heart Rate Reduction Caused by Acupuncture
Chikako Uchida; Hideaki Waki; Yoichi Minakawa; Hideaki Tamai; Tatsuya Hisajima; Kenji Imai
Medical Acupuncture, 01 Apr. 2018, [Reviewed] - Effects of AHCC® on Immune and Stress Responses in Healthy Individuals
Jun Takanari; Atsuya Sato; Hideaki Waki; Shogo Miyazaki; Kazuo Uebaba; Tatsuya Hisajima
Journal of Evidence-Based Integrative Medicine, 01 Jan. 2018, [Reviewed]
AHCC® is a functional food from the basidiomycete Lentinula edodes. We evaluated the effects of AHCC® on subjects under different kinds of stress and at rest. Physical stress was imposed using an active standing test, known as Schellong’s test. Sympathetic nervous activity in the standing position was significantly greater in AHCC®-treated subjects than in a placebo group. In contrast, AHCC® significantly increased parasympathetic nervous activity at rest. Under mental stress, AHCC® increased sympathetic nervous activity, with no difference in the parasympathetic nervous system. In subjects with chronic mental stress, self-reported “initiation and maintenance of sleep” was significantly greater in the AHCC®-intake period than in the placebo intake period, and natural killer cell activity also increased after AHCC® intake, suggesting a possible mechanism of action of AHCC®. Our findings indicate that AHCC® is potentially effective in stress management and may be useful in the treatment of depression. - Effects of electroacupuncture to the trigeminal nerve area on the autonomic nervous system and cerebral blood flow in the prefrontal cortex
Hideaki Waki; Takuya Suzuki; Yuki Tanaka; Hideaki Tamai; Yoichi Minakawa; Shogo Miyazaki; Naruto Yoshida; Kazuo Uebaba; Kenji Imai; Tatsuya Hisajima
ACUPUNCTURE IN MEDICINE, Oct. 2017, [Reviewed] - 皮膚に優しく適用する接触鍼を用いたセルフケアによって、月経痛は軽減するか?(Can self-care by means of contact needles gently applied to the skin relieve menstrual pain?)
Iimura Kaori; Miyazaki Shogo; Imai Kenji; Hisajima Tatsuya
自律神経, Jun. 2017
鍼によるセルフケアの月経痛軽減効果を調べるため、16歳以上の月経痛のある女性19名を無作為に接触鍼治療群またはプラセボ鍼治療群に割り付けた。4月経周期の1日目と2日目に下肢のつぼ3ヶ所に接触鍼またはプラセボ鍼を適用した。試験を終了したのは接触鍼群8名、プラセボ鍼群6名であった。月経痛の変化を100mm視覚アナログ尺度を用いて評価したところ、接触鍼群-17.31mm、プラセボ鍼群-18.83mmで群間差はなかった。接触鍼治療によるセルフケアは月経痛を軽減することが示唆された。しかし、月経痛に対する効果はプラセボ鍼治療によるセルフケアと同等であったことを考慮すると、本試験で認められた疼痛軽減は、プラセボ効果および指圧効果といった非特異的効果によると思われた。 - 大学のラグビー選手の身体的コンディション評価法としてのMeridian Testの有用性(Validity of the Meridian test as an effective assessment tool for evaluating the physical condition of university rugby players)
Okuma Yoshihiro; Waki Hideaki; Yoshida Naruto; Miyazaki Shogo; Hisajima Tatsuya; Takahashi Hidenori; Miyakawa Shumpei; Mukaino Yoshito; TOYOTA VERBLITZ, Rugby team
Japanese Acupuncture and Moxibustion, Mar. 2017, [Reviewed] - Effect of Forefoot Strike on Lower Extremity Muscle Activity and Knee Joint Angle During Cutting in Female Team Handball Players
Naruto Yoshida; Shun Kunugi; Sonoko Mashimo; Yoshihiro Okuma; Akihiko Masunari; Shogo Miyazaki; Tatsuya Hisajima; Shumpei Miyakawa
Sports Medicine - Open, 15 Aug. 2016, [Reviewed] - Effect of stimulation with press tack needle acupuncture on muscle fatigue.
Okuma Yoshihiro, Yoshida Naruto, Miyazaki Shogo, Hisajima Tatsuya, Takahashi Hidenori, Miyakawa Shumpei
Japanese Acupuncture and Moxibustion, Aug. 2016, [Reviewed] - Effect of Enzyme-Treated Asparagus Extract (ETAS) on Psychological Stress in Healthy Individuals
Jun Takanari; Jun Nakahigashi; Atsuya Sato; Hideaki Waki; Shogo Miyazaki; Kazuo Uebaba; Tatsuya Hisajima
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, Jun. 2016, [Reviewed] - Effects of a Gentle, Self-Administered Stimulation of Perineal Skin for Nocturia in Elderly Women: A Randomized, Placebo-Controlled, Double-Blind Crossover Trial
Kaori Iimura; Nobuhiro Watanabe; Koichi Masunaga; Shogo Miyazaki; Harumi Hotta; Hunkyung Kim; Tatsuya Hisajima; Hidenori Takahashi; Yutaka Kasuya
PLOS ONE, 22 Mar. 2016, [Reviewed] - 8. 高齢者の日常生活活動度(ADL)が皮膚電気抵抗値に及ぼす影響
Dec. 2015, [Reviewed] - Effect of 100 Hz electroacupuncture on salivary immunoglobulin A and the autonomic nervous system
Waki Hideaki; Hisajima Tatsuya; Miyazaki Shogo; Yoshida Naruto; Tamai Hideaki; Minakawa Yoichi; Okuma Yoshihiro; Uebaba Kazuo; Takahashi Hidenori
ACUPUNCTURE IN MEDICINE, Dec. 2015, [Reviewed] - Pathological analysis of the Candida albicans-infected tongue tissues of a murine oral candidiasis model in the early infection stage
Masashi Okada; Tatsuya Hisajima; Hiroko Ishibashi; Takahiro Miyasaka; Shigeru Abe; Tazuko Satoh
ARCHIVES OF ORAL BIOLOGY, Apr. 2013, [Reviewed] - 足関節周囲筋の反応時間に与える疲労の影響—The Effect of Fatigue on the Reaction Time of Ankle Muscles
Mar. 2012, [Reviewed] - Increased migration of IgA lymphocytes to VIP nerve fibers after DSS-induced colitis.
Eri Ueno, Tatsuya Hisajima, Masato Nakano, Richard C. Goris, Kengo Funakoshi
Histol Histopathol, May 2011, [Reviewed] - 実験的炎症マウスモデルにおける抗真菌薬リラナフタートの抗炎症効果
丸山 奈保; 安部 美江; 久島 達也; 羽山 和美; 安部 茂
日本医真菌学会雑誌, Jan. 2010, [Reviewed] - Suppression of experimental inflammation by anti-fungal agent liranaftate in mice
Naho Maruyama; Yoshie Abe; Tatsuya Hisajima; Kazumi Hayama; Shigeru Abe
Japanese Journal of Medical Mycology, 2010, [Reviewed] - Enhanced gene replacements inKu80disruption mutants of the dermatophyte,Trichophyton mentagrophytes
Tsuyoshi Yamada; Koichi Makimura; Tatsuya Hisajima; Yumiko Ishihara; Yoshiko Umeda; Shigeru Abe
FEMS Microbiology Letters, Sep. 2009, [Reviewed] - Suppression of anti‐Candida activity of macrophages by a quorum‐sensing molecule, farnesol, through induction of oxidative stress
Shigeru Abe; Rumi Tsunashima; Ryosuke Iijima; Tsuyoshi Yamada; Naho Maruyama; Tatsuya Hisajima; Yoshie Abe; Haruyuki Oshima; Masatoshi Yamazaki
Microbiology and Immunology, 29 May 2009
ABSTRACT
Farnesol is well known as a quorum‐sensing molecule of Candida albicans. To assess the pathological function of farnesol, its effects on macrophage viability and functions including growth inhibitory activities against C. albicans were examined in vitro. Murine macrophages, when cultured in the presence of 56–112 μM of farnesol for 1–2 hr, decreased their activity inhibiting the mycelial growth of C. albicans and lost their viability. This suppression of macrophage function by farnesol was neutralized by the coexistence of the anti‐oxidants probucol and trolox. Macrophages cultured in the presence of farnesol for 2 hr displayed morphological change of nuclei and DNA fragmentation, which suggested apoptosis of the cells. Intracellular production of ROS in the farnesol‐treated macrophages was shown by fluorescence of DCFH‐DA and increase of peroxidized materials. These effects of farnesol were blocked by probucol or trolox. These results indicate that farnesol lowered viability of the murine macrophages and suppressed their anti‐Candida activity, perhaps through induction of ROS. - 鍼灸師養成大学における視覚障害を有する鍼灸師を理解するための教育プログラムの効果について
Mar. 2009, [Reviewed] - 新規低分子化ポリフェノールOligonol の抗酸化作用
2009, [Reviewed] - Psychoneuroimmunologic Effects of Ayurvedic Oil-Dripping Treatment
Kazuo Uebaba; Feng-Hao Xu; Hiroko Ogawa; Takashi Tatsuse; Bing-Hong Wang; Tatsuya Hisajima; Sonia Venkatraman
JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE, Dec. 2008, [Reviewed] - Pharmaco-Physio-Psychologic Effect of Ayurvedic Oil-Dripping Treatment Using an Essential Oil from Lavendula angustifolia
Fenghao Xu; Kazuo Uebaba; Hiroko Ogawa; Takeshi Tatsuse; Bing-Hong Wang; Tatsuya Hisajima; Sonia Venkatraman
JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE, Oct. 2008, [Reviewed] - Protective activity of geranium oil and its component, geraniol, in combination with vaginal washing against vaginal candidiasis in mice
Naho Maruyama; Toshio Takizawa; Hiroko Ishibashi; Tatsuya Hisajima; Shigeharu Inouye; Hideyo Yamaguchi; Shigeru Abe
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Aug. 2008, [Reviewed] - Protective effects of farnesol against oral candidiasis in mice
Tatsuya Hisajima; Naho Maruyama; Yuko Tanabe; Hiroko Ishibashi; Tsuyoshi Yamada; Koichi Makimura; Yayoi Nishiyama; Kengo Funakoshi; Haruyuki Oshima; Shigeru Abe
MICROBIOLOGY AND IMMUNOLOGY, Jul. 2008, [Reviewed] - The supplementation of Oligonol, the new lychee fruit-derived polyphenol converting into a low-molecular form, has a positive effect on fatigue during regular track-and-field training in young athletes.
Ohno H.; Sakurai T.; Hisajima T.; Abe S.; Kizaki T.; Ogasawara J-E.; Ishibashi Y.; Imaizumi, K.; Takemasa T.; Haga S.; Kitadate K.; Nishioka H.; Fujii H.
Adv Exerc Sports Physiol, Apr. 2008, [Reviewed]
Oligonol is a new lychee fruit-derived polyphenol converted into a low-molecular-form, which has improved absorption and strong antioxidative activity. The aim of the current study was to investigate the effects of Oligonol supplementation on perceived subjective mood states in addition to oxidative stress in 47 undergraduate athletes during 52 days of track-and-field training. This was a prospective single blind crossover study. The ratings of perceived exertion (RPE) responses were significantly (P<0.05) lower following Oligonol supplementation, suggesting that Oligonol intake caused the subjects to feel less fatigued during regular training. The results of our own questionnaire on fatigue and pain were as follows: Oligonol supplementation significantly (P<0.05) improved all the fatigue scores and tended to attenuate the feeling of three kinds of pains (muscular/anticular pain, lumbago, and menstrual pain), followed by a change fot the worse after the discontinuance of Oligonol intake. Unexpectedly, however, there were no definite changes in the Profile of Moods States (POMS) scores or oxidative stress markers (8-hydroxy-2'-deoxyguanosine and hexanoyl lysine) in urine after Oligonol supplementation. The results obtained suggest that Oligonol supplementation in young athletes shows significant subjective positive effects particularly on the feeling of fatigue during regular track-and-field training, possibly contributing to the maintenance of good conditioning. - ラベンダーによるアロマトリートメントにおける変性意識体験の促進効果
Mar. 2008, [Reviewed] - Oral candidiasis deteriorated by local application of a glucocorticoid-containing film in a mouse model
Mashiho Yanagi; Tatsuya Hisajima; Hiroko Ishibashi; Ayako Amemiya; Shigeru Abe; Machiko Watanabe
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Feb. 2008, [Reviewed] - Morphological relationships between peptidergic nerve fibers and immunoglobulin A-producing lymphocytes in the mouse intestine
Maiko Shibata; Tatsuya Hisajima; Masato Nakano; Richard C. Goris; Kengo Funakoshi
BRAIN BEHAVIOR AND IMMUNITY, Feb. 2008, [Reviewed] - Invasion process of Candida albicans to tongue surface in early stages of experimental murine oral candidiasis
T. Hisajima; H. Ishibashi; T. Yamada; Y. Nishiyama; H. Yamaguchi; K. Funakoshi; S. Abe
MEDICAL MYCOLOGY, 2008, [Reviewed] - Genetic transformation of the dermatophyte, Trichophyton mentagrophytes, based on the use of G418 resistance as a dominant selectable marker
Tsuyoshi Yamada; Koichi Makimura; Tatsuya Hisajima; Maki Ito; Yoshiko Umeda; Shigeru Abe
Journal of Dermatological Science, Jan. 2008, [Reviewed] - 登山と栄養を再び考える 高所登山における抗酸化サプリメント摂取の意義 Oligonolを中心として
Dec. 2007 - Different effects of carbonated localized bathing of hands and feet on autonomic nervous system.
Xu Fenghao; Ogawa H.; Wang Hongbing; Hisajima T.; Uebaba K.
Evidence Based Complementary and Alternative Medicine, Jul. 2007, [Reviewed] - A murine model of esophageal candidiasis with local characteristic symptoms
Hiroko Ishibashi; Tatsuya Hisajima; Weimin Hu; Hideyo Yamaguchi; Yayoi Nishiyama; Shigeru Abe
MICROBIOLOGY AND IMMUNOLOGY, 2007, [Reviewed] - Morphological analysis of the relation between immunoglobulin A production in the small intestine and the enteric nervous system
T Hisajima; Y Kojima; A Yamaguchi; RC Goris; K Funakoshi
NEUROSCIENCE LETTERS, Jun. 2005, [Reviewed] - Using a healing robot for the scientific study of Shirodhara
K Uebaba; FH Xu; M Tagawa; R Asakura; T Itou; T Tatsuse; Y Taguchi; H Ogawa; M Shimabayashi; T Hisajima
IEEE ENGINEERING IN MEDICINE AND BIOLOGY MAGAZINE, Mar. 2005, [Reviewed] - Medullary efferent and afferent neurons of the facial nerve of the pit viper Gloydius brevicaudus
Y Atobe; M Nakano; T Kadota; T Hisajima; RC Goris; K Funakoshi
JOURNAL OF COMPARATIVE NEUROLOGY, May 2004, [Reviewed] - Psychological Mechanism of Traditional Healing Technique Performed by the Healing Robot –through the life information field-.
Uebaba K.; Xu FH; Tatsuse T.; Taguchi Y.; Ogawa H.; Hisajima T.
J Intl Soc Life Info Sci, Mar. 2004, [Reviewed]
One of the characteristic healing techniques of Traditional Indian Medicine (Ayurveda), Shirodhara (oil dripping treatment on the forehead), was studied by a new modern approach with a healing robot, which provided the standardized reproducible method for Shirodhara. 16 healthy subjects (1^experiment) and 57 healthy subjects (2^ experiment) had Shirodhara with the monitoring of the physiological examinations in the 1^ experiment, and the psychometric questionnaires (STAI and altered state of consciousness : ASC) in the 2^ experiment. During Shirodhara, heart rate and CO_2 excretion decreased, and an alternative marker of sympathetic tone, LF/HF ratio calculated from ECG R-R variability, was suppressed. In the EEG study ,, wave was predominant in the frontal lobe, and frontal midbrain ,, wave appeared during Shirodhara. These physiological changes were supported by the anxiolytic effects of the 2^ experiment associated with altered state of consciousness in the Shirodhara conducted by the healing robot. Both anxiolytic effects and depth of altered state of consciousness are correlated with the skin temperature of the foot during Shirodhara, which indicated the linkage of the physiological and psychological dynamics during Shirodhara. According to the Ayurvedic concept of life, Shirodhara may at first alter the state of consciousness of the inner side of the mind, resulting in the decrease of anxiety of mind level, which was manifested as the suppression of sympathetic nervous activity and the elevation of the foot skin temperature in the body level. The level of consciousness is said to be the life information filed. This mechanism of manifestation of the information field through mind and body level is so similar to biotechnology of the modern medicine, that we call it "Spiritual Biotechnology". - The microvasculature of python pit organs: morphology and blood flow microkinetics
RC Goris; Y Atobe; M Nakano; T Hisajima; K Funakoshi; T Kadota
MICROVASCULAR RESEARCH, May 2003, [Reviewed] - Central projections of thoracic splanchnic and somatic nerves and the location of sympathetic preganglionic neurons in Xenopus laevis
M Nakano; R Kishida; K Funakoshi; M Tsukagoshi; RC Goris; T Kadota; Y Atobe; T Hisajima
JOURNAL OF COMPARATIVE NEUROLOGY, Feb. 2003, [Reviewed] - Distribution of myelinated and unmyelinated nerve fibers and their possible role in blood flow control in crotaline snake infrared receptor organs
T Hisajima; R Kishida; Y Atobe; M Nakano; RC Goris; K Funakoshi
JOURNAL OF COMPARATIVE NEUROLOGY, Aug. 2002, [Reviewed] - Choline acetyltransferase immunoreactive sympathetic ganglion cells in a teleost, Stephanolepis cirrhifer
Kengo Funakoshi; Yoshitoshi Atobe; Tatsuya Hisajima; Masato Nakano; Tetsuo Kadota; Richard C Goris; Reiji Kishida
Autonomic Neuroscience, Jul. 2002, [Reviewed] - Monoaminergic and peptidergic axonal projections to the vagal motor cell column of a teleost, the filefish Stephanotepis cirrhifer
K Funakoshi; Y Atobe; M Nakano; T Hisajima; RC Goris; R Kishida
JOURNAL OF COMPARATIVE NEUROLOGY, Jun. 2002, [Reviewed] - Nervous control of blood flow microkinetics in the infrared organs of pit vipers
R Goris; M Nakano; Y Atobe; T Kadota; K Funakoshi; T Hisajima; R Kishida
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, Oct. 2000, [Reviewed]
MISC
Lectures, oral presentations, etc.
- 脳の循環および機能を変化させる経頭蓋低周波鍼通電刺激
Oct. 2023, [Invited] - 全日本鍼灸学会辞書用語部における活動について 鍼灸学用語集作成とWeb掲載に向けて
May 2023 - 頭部鍼通電刺激による前頭前野領域 脳血流動態の変化
Jun. 2022, [Invited] - 耳鍼を用いたセルフケアが大学生の抑うつに及ぼす効果
May 2022 - 脳機能や脳血流を変化させる鍼治療 〜三叉神経眼枝を介した鍼通電刺激〜
Aug. 2021, [Invited] - 耳鍼を用いたセルフケアで月経前症候群の症状が改善した一症例
May 2021 - 耳鍼を用いたセルフケアで月経前症候群の症状が改善した一症例
May 2021 - 三叉神経眼枝領域への鍼通電刺激が前頭前野機能および脳循環 に与える影響
Feb. 2021, [Invited] - 東洋医学と自律神経1-脳循環- 頭部鍼刺激による脳血流と脳機能への影響
Nov. 2020 - 耳介通電が大学生の学習状況、眠気、抑うつに及ぼす効果
Nov. 2020 - 鍼刺激が不安に関わる前頭前野活動に及ぼす影響
Aug. 2020 - 三叉神経眼枝の鍼通電が暗算時の前頭前野血流と機能に及ぼす影響
Aug. 2020 - 耳鍼が大学生の睡眠、抑うつ、学習状況に及ぼす効果(予備研究)
Aug. 2020 - 前頭前野脳血流に対する三叉神経第一枝への100Hz鍼通電刺激強度の検討
Jun. 2020 - 耳鍼を用いたセルフケアが大学生の眠気や修学状況に及ぼす影響
Jun. 2020 - 前頭前野脳血流に対する三叉神経第一枝への100Hz鍼通電刺激強度の検討
Nov. 2019 - 耳鍼を用いたセルフケアが大学生の眠気や修学状況に及ぼす影響
Nov. 2019 - 鍼治療単独により心室性期外収縮頻度の減少が得られた一症例
Aug. 2019 - 三叉神経第一枝領域への鍼通電刺激において周波数の差異が前頭前野の脳血流量、心拍数及び自律神経活動に及ぼす影響
Jun. 2019 - 前向き症例集積による新規鍼灸受療患者の治療成績に関する概説
皆川 陽一; 宮崎 彰吾; 脇 英彰; 吉田 成仁; 久島 達也
全日本鍼灸学会学術大会抄録集, May 2019, (公社)全日本鍼灸学会 - 耳鍼のセルフケアが大学生の睡眠、抑うつ、学習状況に及ぼす影響
脇 英彰; 鈴木 卓也; 皆川 陽一; 吉田 成仁; 宮崎 彰吾; 久島 達也
全日本鍼灸学会学術大会抄録集, May 2019, (公社)全日本鍼灸学会 - 大学生の不安に対する鍼刺激の効果
May 2019 - 鍼刺激介入時刻の違いが心拍数の減少に及ぼす影響
May 2019 - 前向き症例集積による新規鍼灸受療患者の治療成績に関する概説
May 2019 - 仙骨部への鍼通電刺激が便秘症状に及ぼす影響
Feb. 2019 - 三叉神経第一枝領域への鍼通電刺激において周波数の差異が前頭前野の脳血流量、心拍数及び自律神経活動に及ぼす影響
Oct. 2018 - 鍼刺激が疲労大学生の前頭葉活動および心臓自律機能に及ぼす影響
玉井 秀明; 岸 浩一郎; 菊地 千一郎; 竹内 護; 今井 賢治; 久島 達也
全日本鍼灸学会学術大会抄録集, May 2018, (公社)全日本鍼灸学会 - 鍼刺激がジャンプ着地時の動的アライメントに対して与える影響
秋元 佳子; 吉田 成仁; 脇 英彰; 皆川 陽一; 宮崎 彰吾; 久島 達也
全日本鍼灸学会学術大会抄録集, May 2018, (公社)全日本鍼灸学会 - 鍼刺激に伴う一過性心拍数減少反応に対する覚醒度変化の関与 背景脳波を指標とした検討
内田 千加子; 脇 英彰; 皆川 陽一; 玉井 秀明; 久島 達也; 今井 賢治
全日本鍼灸学会学術大会抄録集, May 2018, (公社)全日本鍼灸学会 - 三叉神経第一枝領域への鍼通電刺激が頸動脈に及ぼす影響
脇 英彰; 鈴木 卓也; 高橋 和文; 今井 賢治; 上馬塲 和夫; 久島 達也
全日本鍼灸学会学術大会抄録集, May 2018, (公社)全日本鍼灸学会 - 鍼通電刺激が抑うつ状態と糞便中sIgA量に及ぼす影響
鈴木 卓也; 脇 英彰; 高橋 和文; 今井 賢治; 上馬塲 和夫; 久島 達也
全日本鍼灸学会学術大会抄録集, May 2018, (公社)全日本鍼灸学会 - 抑うつ症状に関連する潜在性トリガーポイントの特異性
皆川 陽一; 宮崎 彰吾; 脇 英彰; 吉田 成仁; 今井 賢治; 久島 達也
全日本鍼灸学会学術大会抄録集, May 2018, (公社)全日本鍼灸学会 - 鍼刺激に伴う一過性心拍数減少反応に対する覚醒度変化の関与 背景脳波を指標とした検討
May 2018 - 三叉神経第一枝領域への鍼通電刺激が頸動脈に及ぼす影響
May 2018 - 鍼通電刺激が抑うつ状態と糞便中sIgA量に及ぼす影響
May 2018 - 鍼刺激がジャンプ着地時の動的アライメントに対して与える影響
May 2018 - 学生の学習意欲向上への取り組み
May 2018 - 抑うつ症状に関連する潜在性トリガーポイントの特異性
May 2018 - 直流鍼通電刺激による自律神経活動変化の経時的考察
Jun. 2017 - 鍼刺激による心拍数減少反応時の脳機能解析
Jun. 2017 - 鍼通電刺激の部位による違いが自律神経系に及ぼす影響
Jun. 2017 - 実験的トリガーポイントモデルに鍼刺激を行った際のSSRの変化
Jun. 2017 - 三叉神経領域への100Hz鍼通電が自律神経系と前頭前野の脳血流に及ぼす影響
Jun. 2017 - 軽度抑うつの自律神経活動および前頭前野皮質領域脳血流に対する箱庭製作介入の臨床評価
Jun. 2017 - 鍼刺激が睡眠不足および疲労大学生に及ぼす生理学的影響
玉井 秀明; 岸 浩一郎; 菊地 千一郎; 久島 達也; 今井 賢治; 竹内 護; 高橋 秀則
全日本鍼灸学会学術大会抄録集, May 2017, (公社)全日本鍼灸学会 - 仙骨部への低頻度鍼通電刺激介入が排便機能に及ぼす影響
May 2017 - 鍼刺激に伴う一過性の心拍数減少反応時の脳機能解析
May 2017 - 鍼通電が作業効率、自律神経活動、前頭前野の血流量に及ぼす影響
May 2017 - 頸部鍼通電刺激が頭頸肩腕領域愁訴と自律神経活動に及ぼす影響
May 2017 - ST36への直流鍼通電刺激が腰背部傍脊柱部の血流に及ぼす影響
May 2017 - 頸部交感神経節刺鍼による呼吸機能と筋血流量の影響について
May 2017 - 頸部交感神経節近傍刺鍼による自律神経活動と頭頸部血流への影響
May 2017 - トリガーポイント鍼刺激が交感神経皮膚反応に与える影響 トリガーポイントモデルを用いた検討
May 2017 - 直流鍼通電刺激による自律神経活動変化の経時的考察
Nov. 2016 - 鍼通電刺激の部位による違いが自律神経系に及ぼす影響
Nov. 2016 - 実験的トリガーポイントモデルに鍼刺激を行った際のSSRの変化
Nov. 2016 - 三叉神経領域への100Hz鍼通電が自律神経系と前頭前野の脳血流に及ぼす影響
Nov. 2016 - 軽度抑うつの自律神経活動および前頭前野皮質領域脳血流に対する箱庭製作介入の臨床評価
Nov. 2016 - 鍼刺激による心拍数減少反応時の脳機能解析
Nov. 2016 - 健常者における酵素処理アスパラガス抽出物(ETAS)の精神的ストレスに対する効果
Jun. 2016 - 100Hz鍼通電が唾液中分泌型免疫グロブリンAおよび自律神経系に及ぼす影響
Jun. 2016 - 鍼刺激が睡眠不足大学生の前頭葉活動に及ぼす影響
玉井 秀明; 岸 浩一郎; 菊地 千一郎; 久島 達也; 竹内 護; 高橋 秀則
全日本鍼灸学会学術大会抄録集, May 2016, (公社)全日本鍼灸学会 - 直流鍼通電刺激の自律神経機能と気分に及ぼす影響
May 2016 - 鍼通電刺激の部位による違いが自律神経系に及ぼす影響
May 2016 - 運動負荷がFunctional Movement Screenスコアに与える影響
May 2016 - トリガーポイント鍼刺激が交感神経皮膚反応に与える影響 トリガーポイントモデルを用いた検討
May 2016 - 三叉神経第一枝領域への100Hz鍼通電が自律神経系に及ぼす影響
May 2016 - 鍼通電刺激が前頭前野の脳血液量に及ぼす影響
May 2016 - 100Hz鍼通電が唾液中分泌型免疫グロブリンAおよび自律神経系に及ぼす影響
Oct. 2015 - 鍼刺激が睡眠不足および疲労大学生の前頭葉活動に及ぼす影響
玉井 秀明; 岸 浩一郎; 菊地 千一郎; 渡辺 英寿; 久島 達也; 竹内 護; 高橋 秀則
全日本鍼灸学会学術大会抄録集, May 2015, (公社)全日本鍼灸学会 - いじめの未然防止を目的としたM-Testプログラムの効果検証
May 2015 - 軽度抑うつ者の唾液中sIgAに対する鍼通電作用の検討
May 2015 - 経皮的電気刺激と鍼通電刺激が足関節機能的不安定性に及ぼす影響
May 2015 - FAIに対する鍼通電刺激が足関節周囲筋共同収縮に及ぼす影響
May 2015 - 100Hz鍼通電刺激による自律神経活動の変化と抑うつ度の関係
May 2015 - 運動機能に対する運動療法と鍼治療を併用した際の有用性
May 2014 - 100Hz鍼通電刺激が唾液中分泌型IgAおよび自律神経系に及ぼす影響
May 2014 - 女子ハンドボール選手におけるカッティング動作時の下肢筋活動と膝関節外反角度の関連性
Dec. 2013 - 睡眠不足大学生の前頭葉活動に対する鍼刺激の有効性
玉井 秀明; 岸 浩一郎; 菊地 千一郎; 上馬塲 和夫; 渡辺 英寿; 久島 達也; 竹内 護; 高橋 秀則
全日本鍼灸学会学術大会抄録集, Jun. 2013, (公社)全日本鍼灸学会 - ヒトにおける軽い機械的な皮膚刺激による排尿機能への影響 ランダム化プラセボ対照二重盲検交差試験
Jun. 2013 - 手術後に増悪した手根管症候群に対する鍼治療の効果
Jun. 2013 - 鍼刺激が心理的ストレス負荷後の感情および身体機能に及ぼす影響
Jun. 2013 - バランストレーニングが足関節周囲筋の筋連鎖反応に与える影響
Sep. 2012 - 線維筋痛症に対して統合医療的アプローチが有用であった1症例
Jun. 2012 - 唾液中分泌型免疫グロブリンA量および自律神経系に対する鍼刺激の有効性
Jun. 2012 - 慢性腰痛被験者に対するトリガーポイント灸治療の試み 大学生に対するアンケートと灸治療の効果
Jun. 2012 - 女性アスリートの片脚ジャンプ着地時におけるハムストリングスの筋活動
Jun. 2012 - 足関節周囲筋の筋反応時間と足関節機能的不安定性との関連性
Aug. 2011 - 足関節不安定性に対する鍼通電刺激の影響
Aug. 2011 - マウス口腔カンジダ症モデルに対する艾精油成分の有効性
Aug. 2011 - 腸管分泌型IgA産生機構に及ぼす鍼刺激の効果
Aug. 2011 - 高強度運動負荷による唾液中分泌型IgA量低下に対する鍼刺激の有効性
Aug. 2011 - 足関節不安定性が全身反応時間とリバウンドドロップジャンプに及ぼす影響
Dec. 2010 - 全身反応時間とリバウンドドロップジャンプの関連と足関節不安定性による影響
Oct. 2010 - 抗真菌薬リラナフタートは抗炎症効果を示す
Feb. 2010 - Movement of IgA immunocytes toward nerves in the lamina propria of the small intestine
T Hisajima; RC Goris; Y Kojima; K Funakoshi
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, Jul. 2004 - INFRARED SENSORY TERMINAL NERVE MASSES THEMSELVES DIRECTLY CONTROL THE BLOOD FLOW MICROKINETICS IN SNAKE PIT ORGANS
KISHIDA Reiji; NAKANO Masato; ATOBE Yoshitoshi; FUNAKOSHI Kengo; HISAJIMA Tatsuya; GORIS Richard
10 Aug. 2001
Affiliated academic society
Research Themes
- Stress-relieving effects of acupuncture using salivary components as an indicator
Grant-in-Aid for Challenging Research (Exploratory)
Kochi University
Jun. 2022 - Mar. 2025 - 大学教育における伝統医学（鍼灸）のモデル・コア・カリキュラムの構築と検証
Apr. 2022 - Mar. 2025 - 中高年男性の排尿機能に対するノコギリヤシ 抽出物の臨床試験による評価
Apr. 2021 - コーヒー生豆抽出物の健常者に対する臨床効果の検討
May 2020 - オリゴノールならびにその処方品摂取による血流改善およびそれに付随する身体機能への有効性に関する臨床試験
Oct. 2017 - スベリヒユイースト抽出物の健常者に対する臨床効果の検討
Aug. 2017 - 庭作り作業が脳血流に及ぼす影響
Sep. 2015 - 機能性食品が生体機能に及ぼす影響について
Sep. 2015 - アロマオイルを用いたヨガ呼吸法の自律神経機能および免疫機能に及ぼす効果
Apr. 2015 - 口腔カンジダ症モデル白苔形成期の生体防御機
Jun. 2008 - 運動選手における低分子ポリフェノールOligonol®の抗疲労効果に関する臨床試験
Sep. 2006 - ヤマブシダケに関する研究
Jan. 2005
Media Coverage
■Achievement List
Research Seeds
