Clinical effect of phytosterol-enriched saw palmetto extract on urinary function in healthy middle-aged and older males: a double-blind, placebo-controlled randomized comparative study
Tatsuya Hisajima; Hideaki Waki; Takuya Suzuki; Takashi Izumi
Functional Foods in Health and Disease, 09 Feb. 2024
Background: Saw palmetto extract (SPE) is one of the most widely used supplements for benign prostatic hyperplasia (BPH) due to its pharmacological effects. β-sitosterol-enriched saw palmetto oil (VISPO™) contains more than 3% β-sitosterol and 85% total fatty acids and has been shown to improve symptoms in patients with BPH. Lower urinary tract symptoms (LUTS) require primary preventive measures in countries with accelerated population aging, including Japan. VISPO™ is expected to be effective against the early symptoms of LUTS. However, the effect of VISPO™ on urinary function in healthy individuals has not been elucidated.Objective: This clinical study evaluated the efficacy and tolerability of VISPO™ in the management of urinary complaints among healthy middle-aged and older men who did not require treatment.Methods: We conducted a randomized, double-blind, placebo-controlled trial that included 54 male participants who were assigned to consume VISPO™ or placebo (olive oil) capsules for 12 weeks. Biometric data, uroflowmetry results, and salivary hormone levels were assessed at weeks 1 and 12. Urinary function and quality of life were assessed at weeks 1, 4, 8, and 12 using the International Prostate Symptom Score (IPSS), Overactive Bladder Symptom Score (OABSS), Core Lower Urinary Tract Symptom Score (CLSS), and WHOQOL-26.Results: Two-way analysis of variance revealed that IPSS and OABSS were significantly lower in the VISPO™ group that in the placebo group. However, there were no significant differences in urine volume, urinary flow rate, or salivary hormone levels. In addition, no participants reported adverse effects (diarrhea, abdominal pain, etc.). Conclusion: The results of the present study, which is the first randomized controlled trial of VISPO™ conducted among healthy participants, demonstrate the effectiveness of VISPO™ in the management of lower urinary tract complaints that do not require treatment. Trial Registration: University Hospital Medical Information Network Clinical Trials Registry (UMIN000046386).Keywords: saw palmetto, VISPO™, β-sitosterol, fatty acids, healthy subjects, primary preventive, IPSS, OABSS, lower urinary tract symptoms (LUTS)

Effect of transcutaneous vagus nerve stimulation on daytime sleepiness, depression, and study engagement in college students: a randomized controlled trial
Hideaki Waki; Takuya Suzuki; Yoichi Minakawa; Naruto Yoshida; Shogo Miyazaki; Tatsuya Hisajima
VULNERABLE CHILDREN AND YOUTH STUDIES, Mar. 2023

耳鍼を用いたセルフケアで月経前症候群の症状が改善した一症例　　　　　　　　　　　　　　　
May 2021

東洋医学と自律神経1-脳循環- 頭部鍼刺激による脳血流と脳機能への影響　　　　　　　　　　　　　　　
Nov. 2020

耳介通電が大学生の学習状況、眠気、抑うつに及ぼす効果　　　　　　　　　　　　　　　
Nov. 2020

鍼刺激が不安に関わる前頭前野活動に及ぼす影響　　　　　　　　　　　　　　　
Aug. 2020

三叉神経眼枝の鍼通電が暗算時の前頭前野血流と機能に及ぼす影響　　　　　　　　　　　　　　　
Aug. 2020

耳鍼が大学生の睡眠、抑うつ、学習状況に及ぼす効果(予備研究)　　　　　　　　　　　　　　　
Aug. 2020

Acupuncture Relaxation, Vigilance Stage, and Autonomic Nervous System Function: A Comparative Study of Their Interrelationships.
Chikako Uchida; Hideaki Waki; Yoichi Minakawa; Hideaki Tamai; Shogo Miyazaki; Tatsuya Hisajima; Kenji Imai
Medical acupuncture, 01 Aug. 2020
Objective: During acupuncture stimulation, autonomic nervous system (ANS) function changes toward being parasympathetic-dominant, with a transient decrease in heart rate (HR). The aim of this research was to determine the relationships between cortical relaxation and vigilance as observed on background electroencephalograms (EEGs), HR, and ANS function during deep acupuncture. Materials and Methods: This comparative study was conducted at Teikyo Heisei University, in Toshima-ku, Tokyo, Japan, with 27 healthy male volunteers. After resting for 20 minutes, the men received manual acupuncture at LI 10 on the left forearm for 2 minutes at a depth of 15-20 mm at a 1-Hz frequency while undergoing concurrent EEG and electrocardiography (ECG) monitoring. Each subject described his level of comfort during acupuncture. HR; power ratios (normalized units [n.u.]) of EEG alpha, beta, delta, and theta waves; and HR variability (HRV) indices were calculated. Results: In the subgroup who experienced discomfort, delta and theta n.u. were decreased while alpha n.u. were increased, indicating increased vigilance and decreased relaxation. In the subgroup who experienced comfort, there were no significant changes. HRV indices suggested parasympathetic-dominant changes in both subgroups. Weak correlations were observed between a decrease of theta n.u. and sympathetic-dominant changes in HRV indices. Conclusions: Alterations in background EEG activities were not the primary factors changing ANS function to parasympathetic-dominant and decreasing HR, but these alterations related to a weak secondary factor changing ANS function. EEG activity by which cortical relaxation and vigilance were represented was the weak secondary factor changing ANS function during acupuncture; the primary factor might be supraspinal reflection.

前頭前野脳血流に対する三叉神経第一枝への100Hz鍼通電刺激強度の検討　　　　　　　　　　　　　　　
Jun. 2020

耳鍼を用いたセルフケアが大学生の眠気や修学状況に及ぼす影響　　　　　　　　　　　　　　　
Jun. 2020

Electroacupuncture of the Ophthalmic Branch of the Trigeminal Nerve: Effects on Prefrontal Cortex Blood Flow.
Takuya Suzuki; Hideaki Waki; Kenji Imai; Tatsuya Hisajima
Medical acupuncture, 01 Jun. 2020
Objective: The current authors observed enhanced cerebral blood flow (CBF) in the prefrontal cortex (PFC) in response to 100-Hz electroacupuncture (EA) stimulation of the ophthalmic branch of the trigeminal nerve. However, it is not yet clear if responsiveness to 100-Hz EA depends on stimulus intensity. This study examined the effects of stimulus strength on PFC CBF during 100-Hz EA of the ophthalmic branch of the trigeminal nerve. Materials and Methods: Twelve subjects underwent 3 acupuncture sessions: I, control, no stimulation; II, 0.1 mA EA; and III, 0.2 mA EA). Needles were inserted 1 cm lateral of the head median line; the anterior insertion point was on the front hairline and the posterior insertion point was ∼7 cm behind the hairline. Stimulation frequency was set to 100-Hz. PFC CBF was measured in terms of oxygenated, deoxygenated, and total hemoglobin (OxyHb, DeoxyHb, TotalHb, respectively), using 16-channel (Ch) near-infrared spectroscopy. Results: Stimulation of 0.2 mA was associated with significant elevation of OxyHb levels in the 0.1 mA condition in Chs 6, 10, and 12. Ch 2-6, 10, 12 signals were notably higher than in the control condition. Stimulation of 0.2 mA and 0.1 mA were associated with significant declines in DeoxyHb levels, compared to the control condition in Ch 4. Finally, 0.2 mA stimulation in Chs 12 and 13 was associated with significant elevation of TotalHb levels in the control condition. Conclusions: Using 0.2-mA stimulation, 100-Hz EA of the ophthalmic nerve enhances PFC CBF more strongly than 0.1-mA stimulation.

Effects of a Standardized Oligomerized-Polyphenol from Litchi chinensis Fruit Extract and Mixed Plant Extract Supplementation on Peripheral Circulation and Cold Sensitivity.
Hideaki Waki; Takuya Suzuki; Kazuo Uebaba; Tatsuya Hisajima
Journal of nutritional science and vitaminology, 2020
Certain individuals tend to suffer from a cold sensation-particularly in the lower extremities-despite most people not suffering from the same sensation. In Japan, this phenomenon is called "hie-sho" and reduces quality of life for several people, particularly women. A previous study has shown that a standardized oligomerized-polyphenol from Litchi chinensis fruit extract (OPLFE) reportedly causes a significant increase in body surface temperature. The present study aimed to investigate whether supplementation with OPLFE affected peripheral circulation and cold sensitivity. This randomized, double-blind, placebo-controlled trial was performed including 25 participants (age, 45.0±10.4 y; 3 males and 22 females) who were assigned to consume OPLFE, mixed plant extract with OPLFE, or placebo capsules for 14 d. Participants were instructed to relax for 60 min in a temperature-controlled room prior to obtaining measurements. Changes in skin temperature and peripheral blood flow of the middle finger were assessed immediately before and 1, 5, 10, 20, and 30 min after immersion in cold water (10ºC). Participants' height, weight, skin temperature, and blood flow in peripheral tissue were measured; furthermore, their "hie-sho" was measured using the Visual Analog Scale (VAS). Skin temperature and blood flow in peripheral tissue increased in the OPLFE and mixed plant extract with OPLFE groups on day 14 compared with those on day 1. In addition, cold sensitivity in these two groups significantly improved between day 1 and day 14. These findings suggest that OPLFE improves "hie-sho" by increasing peripheral blood flow and skin temperature.

Effects of stimulus strength on prefrontal cortex blood flow during 100-Hz electroacupuncture of the ophthalmic branch of the trigeminal nerve. (submitted)　　　　　　　　　　　　　　　
HISAJIMA Tatsuya
Acupunct Med, Dec. 2019, [Reviewed]

前頭前野脳血流に対する三叉神経第一枝への100Hz鍼通電刺激強度の検討　　　　　　　　　　　　　　　
Nov. 2019

耳鍼を用いたセルフケアが大学生の眠気や修学状況に及ぼす影響　　　　　　　　　　　　　　　
Nov. 2019

鍼治療単独により心室性期外収縮頻度の減少が得られた一症例
Aug. 2019

三叉神経第一枝領域への鍼通電刺激において周波数の差異が前頭前野の脳血流量、心拍数及び自律神経活動に及ぼす影響　　　　　　　　　　　　　　　
Jun. 2019

大学生の不安に対する鍼刺激の効果　　　　　　　　　　　　　　　
May 2019

鍼刺激介入時刻の違いが心拍数の減少に及ぼす影響　　　　　　　　　　　　　　　
May 2019

前向き症例集積による新規鍼灸受療患者の治療成績に関する概説　　　　　　　　　　　　　　　
May 2019

耳鍼のセルフケアが大学生の睡眠、抑うつ、学習状況に及ぼす影響　　　　　　　　　　　　　　　
May 2019

仙骨部への鍼通電刺激が便秘症状に及ぼす影響　　　　　　　　　　　　　　　
Feb. 2019

Effects of Cathode Direct-Current Electroacupuncture Stimulus of the Promixal Anterior Lower Limbs on Heart Rate and Lumbar Blood Flow. (in press)　　　　　　　　　　　　　　　
HISAJIMA Tatsuya
Medical Acupuncture, 2019, [Reviewed]

Effects of Acupuncture Sensations on Transient Heart Rate Reduction and Autonomic Nervous System Function During Acupuncture Stimulation.　　　　　　　　　　　　　　　
HISAJIMA Tatsuya
Medical Acupuncture, Jan. 2019, [Reviewed]

三叉神経第一枝領域への鍼通電刺激において周波数の差異が前頭前野の脳血流量、心拍数及び自律神経活動に及ぼす影響　　　　　　　　　　　　　　　
Oct. 2018

鍼刺激に伴う一過性心拍数減少反応に対する覚醒度変化の関与 背景脳波を指標とした検討　　　　　　　　　　　　　　　
May 2018

三叉神経第一枝領域への鍼通電刺激が頸動脈に及ぼす影響　　　　　　　　　　　　　　　
May 2018

鍼通電刺激が抑うつ状態と糞便中sIgA量に及ぼす影響　　　　　　　　　　　　　　　
May 2018

鍼刺激がジャンプ着地時の動的アライメントに対して与える影響　　　　　　　　　　　　　　　
May 2018

抑うつ症状に関連する潜在性トリガーポイントの特異性　　　　　　　　　　　　　　　
May 2018

Evaluation of Autonomic Nervous System Function Using Heart Rate Variability Analysis during Transient Heart Rate Reduction Caused by Acupuncture
Chikako Uchida; Hideaki Waki; Yoichi Minakawa; Hideaki Tamai; Tatsuya Hisajima; Kenji Imai
Medical Acupuncture, 01 Apr. 2018, [Reviewed]

Effects of AHCC® on Immune and Stress Responses in Healthy Individuals.　　　　　　　　　　　　　　　
HISAJIMA Tatsuya
Journal of Evidence-Based Integrative Medicine, Mar. 2018, [Reviewed]

Effects of electroacupuncture to the trigeminal nerve area on the autonomic nervous system and cerebral blood flow in the prefrontal cortex
Hideaki Waki; Takuya Suzuki; Yuki Tanaka; Hideaki Tamai; Yoichi Minakawa; Shogo Miyazaki; Naruto Yoshida; Kazuo Uebaba; Kenji Imai; Tatsuya Hisajima
ACUPUNCTURE IN MEDICINE, Oct. 2017, [Reviewed]

直流鍼通電刺激による自律神経活動変化の経時的考察　　　　　　　　　　　　　　　
Jun. 2017

鍼刺激による心拍数減少反応時の脳機能解析　　　　　　　　　　　　　　　
Jun. 2017

鍼通電刺激の部位による違いが自律神経系に及ぼす影響　　　　　　　　　　　　　　　
Jun. 2017

実験的トリガーポイントモデルに鍼刺激を行った際のSSRの変化　　　　　　　　　　　　　　　
Jun. 2017

三叉神経領域への100Hz鍼通電が自律神経系と前頭前野の脳血流に及ぼす影響　　　　　　　　　　　　　　　
Jun. 2017

軽度抑うつの自律神経活動および前頭前野皮質領域脳血流に対する箱庭製作介入の臨床評価　　　　　　　　　　　　　　　
Jun. 2017

仙骨部への低頻度鍼通電刺激介入が排便機能に及ぼす影響　　　　　　　　　　　　　　　
May 2017

鍼刺激に伴う一過性の心拍数減少反応時の脳機能解析　　　　　　　　　　　　　　　
May 2017

鍼通電が作業効率、自律神経活動、前頭前野の血流量に及ぼす影響　　　　　　　　　　　　　　　
May 2017

頸部鍼通電刺激が頭頸肩腕領域愁訴と自律神経活動に及ぼす影響　　　　　　　　　　　　　　　
May 2017

ST36への直流鍼通電刺激が腰背部傍脊柱部の血流に及ぼす影響　　　　　　　　　　　　　　　
May 2017

頸部交感神経節刺鍼による呼吸機能と筋血流量の影響について　　　　　　　　　　　　　　　
May 2017

頸部交感神経節近傍刺鍼による自律神経活動と頭頸部血流への影響　　　　　　　　　　　　　　　
May 2017

トリガーポイント鍼刺激が交感神経皮膚反応に与える影響 トリガーポイントモデルを用いた検討　　　　　　　　　　　　　　　
May 2017

大学のラグビー選手の身体的コンディション評価法としてのMeridian Testの有用性(Validity of the Meridian test as an effective assessment tool for evaluating the physical condition of university rugby players)
Okuma Yoshihiro; Waki Hideaki; Yoshida Naruto; Miyazaki Shogo; Hisajima Tatsuya; Takahashi Hidenori; Miyakawa Shumpei; Mukaino Yoshito; TOYOTA VERBLITZ, Rugby team
Japanese Acupuncture and Moxibustion, Mar. 2017

直流鍼通電刺激による自律神経活動変化の経時的考察　　　　　　　　　　　　　　　
Nov. 2016

鍼通電刺激の部位による違いが自律神経系に及ぼす影響　　　　　　　　　　　　　　　
Nov. 2016

実験的トリガーポイントモデルに鍼刺激を行った際のSSRの変化　　　　　　　　　　　　　　　
Nov. 2016

三叉神経領域への100Hz鍼通電が自律神経系と前頭前野の脳血流に及ぼす影響　　　　　　　　　　　　　　　
Nov. 2016

軽度抑うつの自律神経活動および前頭前野皮質領域脳血流に対する箱庭製作介入の臨床評価　　　　　　　　　　　　　　　
Nov. 2016

鍼刺激による心拍数減少反応時の脳機能解析　　　　　　　　　　　　　　　
Nov. 2016

Effect of stimulation with press tack needle acupuncture on muscle fatigue.　　　　　　　　　　　　　　　
HISAJIMA Tatsuya
Japanese Acupuncture and Moxibustion, Aug. 2016, [Reviewed]

Effect of Forefoot Strike on Lower Extremity Muscle Activity and Knee Joint Angle During Cutting in Female Team Handball Players.　　　　　　　　　　　　　　　
HISAJIMA Tatsuya
Sports Med Open, Aug. 2016, [Reviewed]

健常者における酵素処理アスパラガス抽出物(ETAS)の精神的ストレスに対する効果　　　　　　　　　　　　　　　
Jun. 2016

100Hz鍼通電が唾液中分泌型免疫グロブリンAおよび自律神経系に及ぼす影響　　　　　　　　　　　　　　　
Jun. 2016

Effect of Enzyme-Treated Asparagus Extract (ETAS) on Psychological Stress in Healthy Individuals
Jun Takanari; Jun Nakahigashi; Atsuya Sato; Hideaki Waki; Shogo Miyazaki; Kazuo Uebaba; Tatsuya Hisajima
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, Jun. 2016, [Reviewed]

直流鍼通電刺激の自律神経機能と気分に及ぼす影響　　　　　　　　　　　　　　　
May 2016

鍼通電刺激の部位による違いが自律神経系に及ぼす影響　　　　　　　　　　　　　　　
May 2016

運動負荷がFunctional Movement Screenスコアに与える影響　　　　　　　　　　　　　　　
May 2016

トリガーポイント鍼刺激が交感神経皮膚反応に与える影響 トリガーポイントモデルを用いた検討　　　　　　　　　　　　　　　
May 2016

三叉神経第一枝領域への100Hz鍼通電が自律神経系に及ぼす影響　　　　　　　　　　　　　　　
May 2016

鍼通電刺激が前頭前野の脳血液量に及ぼす影響　　　　　　　　　　　　　　　
May 2016

Effects of a Gentle, Self-Administered Stimulation of Perineal Skin for Nocturia in Elderly Women: A Randomized, Placebo-Controlled, Double-Blind Crossover Trial
Kaori Iimura; Nobuhiro Watanabe; Koichi Masunaga; Shogo Miyazaki; Harumi Hotta; Hunkyung Kim; Tatsuya Hisajima; Hidenori Takahashi; Yutaka Kasuya
PLOS ONE, Mar. 2016, [Reviewed]

Effect of 100 Hz electroacupuncture on salivary immunoglobulin A and the autonomic nervous system
Waki Hideaki; Hisajima Tatsuya; Miyazaki Shogo; Yoshida Naruto; Tamai Hideaki; Minakawa Yoichi; Okuma Yoshihiro; Uebaba Kazuo; Takahashi Hidenori
ACUPUNCTURE IN MEDICINE, Dec. 2015, [Reviewed]

100Hz鍼通電が唾液中分泌型免疫グロブリンAおよび自律神経系に及ぼす影響　　　　　　　　　　　　　　　
Oct. 2015

いじめの未然防止を目的としたM-Testプログラムの効果検証　　　　　　　　　　　　　　　
May 2015

軽度抑うつ者の唾液中sIgAに対する鍼通電作用の検討　　　　　　　　　　　　　　　
May 2015

経皮的電気刺激と鍼通電刺激が足関節機能的不安定性に及ぼす影響　　　　　　　　　　　　　　　
May 2015

FAIに対する鍼通電刺激が足関節周囲筋共同収縮に及ぼす影響　　　　　　　　　　　　　　　
May 2015

100Hz鍼通電刺激による自律神経活動の変化と抑うつ度の関係　　　　　　　　　　　　　　　
May 2015

M-Testによって検索される経絡および経穴へのやさしいタッチはストレスを緩和させるか
Mar. 2015

運動機能に対する運動療法と鍼治療を併用した際の有用性　　　　　　　　　　　　　　　
May 2014

100Hz鍼通電刺激が唾液中分泌型IgAおよび自律神経系に及ぼす影響　　　　　　　　　　　　　　　
May 2014

心理的ストレス応答に対する低周波鍼通電の効果について 自律神経機能および分泌型免疫グロブリンA量への影響
Oct. 2013

ヒトにおける軽い機械的な皮膚刺激による排尿機能への影響 ランダム化プラセボ対照二重盲検交差試験　　　　　　　　　　　　　　　
Jun. 2013

手術後に増悪した手根管症候群に対する鍼治療の効果　　　　　　　　　　　　　　　
Jun. 2013

鍼刺激が心理的ストレス負荷後の感情および身体機能に及ぼす影響　　　　　　　　　　　　　　　
Jun. 2013

Pathological analysis of the Candida albicans-infected tongue tissues of a murine oral candidiasis model in the early infection stage
Masashi Okada; Tatsuya Hisajima; Hiroko Ishibashi; Takahiro Miyasaka; Shigeru Abe; Tazuko Satoh
ARCHIVES OF ORAL BIOLOGY, Apr. 2013, [Reviewed]

線維筋痛症に対して統合医療的アプローチが有用であった1症例　　　　　　　　　　　　　　　
Jun. 2012

唾液中分泌型免疫グロブリンA量および自律神経系に対する鍼刺激の有効性　　　　　　　　　　　　　　　
Jun. 2012

慢性腰痛被験者に対するトリガーポイント灸治療の試み 大学生に対するアンケートと灸治療の効果　　　　　　　　　　　　　　　
Jun. 2012

大学生スポーツ選手の相補・代替医療利用状況
Apr. 2012

マウス口腔カンジダ症モデルに対する艾精油成分の有効性　　　　　　　　　　　　　　　
Aug. 2011

腸管分泌型IgA産生機構に及ぼす鍼刺激の効果　　　　　　　　　　　　　　　
Aug. 2011

高強度運動負荷による唾液中分泌型IgA量低下に対する鍼刺激の有効性　　　　　　　　　　　　　　　
Aug. 2011

Increased migration of IgA lymphocytes to VIP nerve fibers after DSS-induced colitis.　　　　　　　　　　　　　　　
HISAJIMA Tatsuya
Histol Histopathol, May 2011, [Reviewed]

Suppression of experimental inflammation by anti-fungal agent liranaftate in mice
Naho Maruyama; Yoshie Abe; Tatsuya Hisajima; Kazumi Hayama; Shigeru Abe
Japanese Journal of Medical Mycology, 2010, [Reviewed]

Enhanced gene replacements in Ku80 disruption mutants of the dermatophyte, Trichophyton mentagrophytes.　　　　　　　　　　　　　　　
HISAJIMA Tatsuya
FEMS Microbiol Lett, Feb. 2009, [Reviewed]

Suppression of anti-Candida activity of macrophages by a quorum-sensing molecule, farnesol, through induction of oxidative stress.　　　　　　　　　　　　　　　
HISAJIMA Tatsuya
Microbiology and Immunology, Feb. 2009, [Reviewed]

Psychoneuroimmunologic Effects of Ayurvedic Oil-Dripping Treatment
Kazuo Uebaba; Feng-Hao Xu; Hiroko Ogawa; Takashi Tatsuse; Bing-Hong Wang; Tatsuya Hisajima; Sonia Venkatraman
JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE, Dec. 2008, [Reviewed]

Pharmaco-Physio-Psychologic Effect of Ayurvedic Oil-Dripping Treatment Using an Essential Oil from Lavendula angustifolia
Fenghao Xu; Kazuo Uebaba; Hiroko Ogawa; Takeshi Tatsuse; Bing-Hong Wang; Tatsuya Hisajima; Sonia Venkatraman
JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE, Oct. 2008, [Reviewed]

Protective activity of geranium oil and its component, geraniol, in combination with vaginal washing against vaginal candidiasis in mice
Naho Maruyama; Toshio Takizawa; Hiroko Ishibashi; Tatsuya Hisajima; Shigeharu Inouye; Hideyo Yamaguchi; Shigeru Abe
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Aug. 2008, [Reviewed]

Protective effects of farnesol against oral candidiasis in mice
Tatsuya Hisajima; Naho Maruyama; Yuko Tanabe; Hiroko Ishibashi; Tsuyoshi Yamada; Koichi Makimura; Yayoi Nishiyama; Kengo Funakoshi; Haruyuki Oshima; Shigeru Abe
MICROBIOLOGY AND IMMUNOLOGY, Jul. 2008, [Reviewed]

The supplementation of Oligonol, the new lychee fruit-derived polyphenol converting into a low-molecular form, has a positive effect on fatigue during regular track-and-field training in young athletes.
HISAJIMA Tatsuya
Adv Exerc Sports Physiol, Apr. 2008, [Reviewed]
Oligonol is a new lychee fruit-derived polyphenol converted into a low-molecular-form, which has improved absorption and strong antioxidative activity. The aim of the current study was to investigate the effects of Oligonol supplementation on perceived subjective mood states in addition to oxidative stress in 47 undergraduate athletes during 52 days of track-and-field training. This was a prospective single blind crossover study. The ratings of perceived exertion (RPE) responses were significantly (P<0.05) lower following Oligonol supplementation, suggesting that Oligonol intake caused the subjects to feel less fatigued during regular training. The results of our own questionnaire on fatigue and pain were as follows: Oligonol supplementation significantly (P<0.05) improved all the fatigue scores and tended to attenuate the feeling of three kinds of pains (muscular/anticular pain, lumbago, and menstrual pain), followed by a change fot the worse after the discontinuance of Oligonol intake. Unexpectedly, however, there were no definite changes in the Profile of Moods States (POMS) scores or oxidative stress markers (8-hydroxy-2'-deoxyguanosine and hexanoyl lysine) in urine after Oligonol supplementation. The results obtained suggest that Oligonol supplementation in young athletes shows significant subjective positive effects particularly on the feeling of fatigue during regular track-and-field training, possibly contributing to the maintenance of good conditioning.

Oral candidiasis deteriorated by local application of a glucocorticoid-containing film in a mouse model
Mashiho Yanagi; Tatsuya Hisajima; Hiroko Ishibashi; Ayako Amemiya; Shigeru Abe; Machiko Watanabe
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Feb. 2008, [Reviewed]

Morphological relationships between peptidergic nerve fibers and immunoglobulin A-producing lymphocytes in the mouse intestine
Maiko Shibata; Tatsuya Hisajima; Masato Nakano; Richard C. Goris; Kengo Funakoshi
BRAIN BEHAVIOR AND IMMUNITY, Feb. 2008, [Reviewed]

Invasion process of Candida albicans to tongue surface in early stages of experimental murine oral candidiasis
T. Hisajima; H. Ishibashi; T. Yamada; Y. Nishiyama; H. Yamaguchi; K. Funakoshi; S. Abe
MEDICAL MYCOLOGY, 2008, [Reviewed]

Genetic transformation of the dermatophyte, Trichophyton mentagrophytes, based on the use of G418 resistance as a dominant selectable marker
Tsuyoshi Yamada; Koichi Makimura; Tatsuya Hisajima; Maki Ito; Yoshiko Umeda; Shigeru Abe
Journal of Dermatological Science, Jan. 2008, [Reviewed]

Different effects of carbonated localized bathing of hands and feet on autonomic nervous system.　　　　　　　　　　　　　　　
HISAJIMA Tatsuya
Evidence Based Complementary and Alternative Medicine, Jul. 2007, [Reviewed]

A murine model of esophageal candidiasis with local characteristic symptoms
Hiroko Ishibashi; Tatsuya Hisajima; Weimin Hu; Hideyo Yamaguchi; Yayoi Nishiyama; Shigeru Abe
MICROBIOLOGY AND IMMUNOLOGY, 2007, [Reviewed]

Morphological analysis of the relation between immunoglobulin A production in the small intestine and the enteric nervous system
T Hisajima; Y Kojima; A Yamaguchi; RC Goris; K Funakoshi
NEUROSCIENCE LETTERS, Jun. 2005, [Reviewed]

Using a healing robot for the scientific study of Shirodhara
K Uebaba; FH Xu; M Tagawa; R Asakura; T Itou; T Tatsuse; Y Taguchi; H Ogawa; M Shimabayashi; T Hisajima
IEEE ENGINEERING IN MEDICINE AND BIOLOGY MAGAZINE, Mar. 2005, [Reviewed]

Medullary efferent and afferent neurons of the facial nerve of the pit viper Gloydius brevicaudus
Y Atobe; M Nakano; T Kadota; T Hisajima; RC Goris; K Funakoshi
JOURNAL OF COMPARATIVE NEUROLOGY, May 2004, [Reviewed]

Psychological Mechanism of Traditional Healing Technique Performed by the Healing Robot –through the life information field-.　　　　　　　　　　　　　　　
HISAJIMA Tatsuya
J Intl Soc Life Info Sci, Mar. 2004, [Reviewed]

The microvasculature of python pit organs: morphology and blood flow microkinetics
RC Goris; Y Atobe; M Nakano; T Hisajima; K Funakoshi; T Kadota
MICROVASCULAR RESEARCH, May 2003, [Reviewed]

Central projections of thoracic splanchnic and somatic nerves and the location of sympathetic preganglionic neurons in Xenopus laevis
M Nakano; R Kishida; K Funakoshi; M Tsukagoshi; RC Goris; T Kadota; Y Atobe; T Hisajima
JOURNAL OF COMPARATIVE NEUROLOGY, Feb. 2003, [Reviewed]

Distribution of myelinated and unmyelinated nerve fibers and their possible role in blood flow control in crotaline snake infrared receptor organs
T Hisajima; R Kishida; Y Atobe; M Nakano; RC Goris; K Funakoshi
JOURNAL OF COMPARATIVE NEUROLOGY, Aug. 2002, [Reviewed]

Choline acetyltransferase immunoreactive sympathetic ganglion cells in a teleost, Stephanolepis cirrhifer.　　　　　　　　　　　　　　　
HISAJIMA Tatsuya
Auton Neurosci, Jun. 2002, [Reviewed]

Monoaminergic and peptidergic axonal projections to the vagal motor cell column of a teleost, the filefish Stephanotepis cirrhifer
K Funakoshi; Y Atobe; M Nakano; T Hisajima; RC Goris; R Kishida
JOURNAL OF COMPARATIVE NEUROLOGY, Jun. 2002, [Reviewed]

Nervous control of blood flow microkinetics in the infrared organs of pit vipers
R Goris; M Nakano; Y Atobe; T Kadota; K Funakoshi; T Hisajima; R Kishida
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, Oct. 2000, [Reviewed]

前向き症例集積による新規鍼灸受療患者の治療成績に関する概説　　　　　　　　　　　　　　　
皆川 陽一; 宮崎 彰吾; 脇 英彰; 吉田 成仁; 久島 達也
全日本鍼灸学会学術大会抄録集, May 2019
(公社)全日本鍼灸学会

耳鍼のセルフケアが大学生の睡眠、抑うつ、学習状況に及ぼす影響　　　　　　　　　　　　　　　
脇 英彰; 鈴木 卓也; 皆川 陽一; 吉田 成仁; 宮崎 彰吾; 久島 達也
全日本鍼灸学会学術大会抄録集, May 2019
(公社)全日本鍼灸学会

鍼刺激がジャンプ着地時の動的アライメントに対して与える影響　　　　　　　　　　　　　　　
秋元 佳子; 吉田 成仁; 脇 英彰; 皆川 陽一; 宮崎 彰吾; 久島 達也
全日本鍼灸学会学術大会抄録集, May 2018
(公社)全日本鍼灸学会

鍼刺激に伴う一過性心拍数減少反応に対する覚醒度変化の関与 背景脳波を指標とした検討　　　　　　　　　　　　　　　
内田 千加子; 脇 英彰; 皆川 陽一; 玉井 秀明; 久島 達也; 今井 賢治
全日本鍼灸学会学術大会抄録集, May 2018
(公社)全日本鍼灸学会

抑うつ症状に関連する潜在性トリガーポイントの特異性　　　　　　　　　　　　　　　
皆川 陽一; 宮崎 彰吾; 脇 英彰; 吉田 成仁; 今井 賢治; 久島 達也
全日本鍼灸学会学術大会抄録集, May 2018
(公社)全日本鍼灸学会

Movement of IgA immunocytes toward nerves in the lamina propria of the small intestine
T Hisajima; RC Goris; Y Kojima; K Funakoshi
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, Jul. 2004