Yasutomo Sakai

Faculty of Health and Medical Science,Department of Physical TherapyProfessor
Graduate School of Health Sciences,Doctoral Program in Health SciencesProfessor
Graduate School of Health Sciences,Master's and Doctoral Programs in Physical TherapyProfessor
Last Updated :2025/10/07

■Researcher basic information

Degree

  • Doctorate (Science and Technology), Nihon University, Mar. 2000
  • Master's (Science and Technology), Nihon University, Mar. 1995
  • Bachelor's (Liberal Arts), The Open University of Japan, Mar. 1993

Research Keyword

  • Physical Therapy
  • Physical Fitness
  • Morphology of Skeletal Muscle

Field Of Study

  • Life sciences, Hygiene and public health (non-laboratory)
  • Life sciences, Hygiene and public health (laboratory)
  • Life sciences, Healthcare management, medical sociology
  • Life sciences, Physiology
  • Life sciences, Anatomy

■Career

Career

  • Apr. 2011
    Teikyo Heisei University, Graduate School of Health Sciences, Doctoral Program in Health Sciences, Physical Therapy., Professor
  • Apr. 2011
    Teikyo Heisei University, Graduate School of Health Sciences, Master's Program in Physical Therapy., Professor
  • Apr. 2011
    Teikyo Heisei University, Faculty of Health and Medical Science, Department of Physical Therapy, Professor
  • Apr. 2007 - Mar. 2011
    Teikyo Heisei University, Faculty of Health and Medical Science, Department of Physical Therapy, Associate Professor
  • Apr. 2003 - Mar. 2007
    Ibaraki Prefectural University of Health Sciences, School of Health Sciences, Department of Physical Therapy, Assistant Professor
  • Dec. 1996 - Mar. 2007
    Ibaraki Prefectural University of Health Sciences Hospital, Rehabilitation Department, Physical Therapist (clinical duties)
  • Apr. 1995 - Mar. 2003
    Ibaraki Prefectural University of Medical Sciences, Faculty of Health Care and Medicine, Department of Physical Therapy, Assistant Professor
  • Jan. 1994 - Mar. 1995
    Tokyo Metropolitan Rehabilitation Hospital, Department of Rehabilitation, Administrative Assistant (Physiotherapist)
  • Apr. 1987 - Dec. 1993
    Rehabilitation Department, Sousen Hospital, Seikei-Kai, Physiotherapist

Educational Background

  • Apr. 1995 - Mar. 2000, Nihon University, Doctoral Program (Post-Master's) in Medical and Welfare Engineering, Graduate School of Science and Technology.
  • Apr. 1993 - Mar. 1995, Nihon University, Master's Program in Medical and Welfare Engineering, Graduate School of Science and Technology.
  • Apr. 1989 - Mar. 1993, The Open University of Japan, Faculty of Liberal Arts, Living and Welfare

Member History

  • 1997 - 2000

■Research activity information

Paper

MISC

Books and other publications

  • 筋機能改善の理学療法とそのメカニズム : 第1部 筋機能改善の理学療法-第3章 持久力改善の理学療法　　　　　　　　　　　　　　　
    2001
  • ホームヘルパーのための介護サービス用語集　　　　　　　　　　　　　　　
    2001
  • バトラー・神経系モビライゼーション-触診と治療技術　　　　　　　　　　　　　　　
    2000
  • 福祉機器情報のバリアフリーに対するインターネット開発((]G0008[)章)　　　　　　　　　　　　　　　
    1999
  • 身体障害者スクーバ・ダイビング用リフターの開発((]G0010[)(]G0001[)章)　　　　　　　　　　　　　　　
    1999
  • 福祉介護におけるインターネット開発と病院情報システムの実現に向けて　　　　　　　　　　　　　　　
    1997
  • 多段階的抵抗訓練具セラバンド-訓練の手引き-　　　　　　　　　　　　　　　
    1995
  • Thera-Band,System of Progressive Resistance ; manual of exercise　　　　　　　　　　　　　　　
    1995

Research Themes

  • Mitochondrial DNA Damage and Morphological Change in Disuse Atrophied Skeletal Muscles and Effect of Therapeutic Exercise
    Grant-in-Aid for Scientific Research (C)
    IBARAKI PREFECTURAL UNIVERSITY OF HEALTH SCIENCES
    1999 - 2001
    1) Mitochondrial DNA damage and morphological change in disuse atrophy :
    In this research project we studied mitochondrial DNA (mtDNA) deletion of cells and microstructural changes from the rat soleus muscle subjected to disuse atrophy by hind-limb suspension for two or four weeks. No such deletions were detected in the mtDNA from two weeks of free weight-bearing after two weeks of hind-limb suspension. After two weeks of disuse atrophy, many mitochondrial structures in the muscle were miniaturized and other structures became blurred. And also molten thin actin filaments were found on the periphery of the Z-disk. After four weeks of disuse, alignment of the fibrils became ragged the Z-disks were deteriorated.
    2) Stretching and disuse atrophy of skeletal muscle :
    In this project we investigated the extent of atrophic change and recovery from skeletal muscle subjected to hind-limb suspension for two weeks with the soleus in an elongated position. Whereas disuse atrophy muscles without stretching decreased in wet-weight and in total RNA, based on inhibition of gene expression and genetic transcription in the protein metabolism, preliminary results suggested that muscle stretching may induce inhibitory action of muscle atrophy.
    3) Effect of therapeutic exercise on disuse atrophied skeletal muscles :
    Both acute overload exercise and disuse atrophy have induced mtDNA deletion with muscle ultra-structural damage in this research project. Nevertheless, endurance exercise and muscle stretching appear to provide effective means to inhibit muscle atrophy, so then this project will focus on the potential importance of these methods in therapeutic exercise.
    4) Conclusion :
    Disuse atrophy leads to oxidative stress, damage of muscle tissue and mutation of mtDNA. The association of damage due to disuse atrophy with oxidative stress may have clinical implications in determining what form of therapeutic exercise in beneficial in preventing or suppressing such damage. We will be pursuing this question.
  • Estimation of Balancing dysfunction in Pusher syndrome(Stroke)　　　　　　　　　　　　　　　
  • Study of Oxidation-Stress and Skeletal Muscles　　　　　　　　　　　　　　　
  • Ultrastructural and Mitochondria-genetic Studies of Skeletal Muscles　　　　　　　　　　　　　　　

■University education and qualification information

Qualifications, licenses

  • 01 Jun. 1987
  • 01 Aug. 2010