Jul. 2024

Nov. 2019

外来通院する潰瘍性大腸炎患者が抱える疾病に伴う不安の尺度開発　　　　　　　　　　　　　　　
Mar. 2025

Development of a decision support tool for patients with Crohn's disease considering biologic treatment
Maya Nunotani; Miho Takahashi; Nobuo Aoyama
Journal of International Nursing Research, 20 Feb. 2025, [Reviewed]

Development of a Burden Scale for Colonoscopy Experienced by Patients with Inflammatory Bowel Disease
Maya Nunotani; Miho Takahashi; Takuro Miyazaki
Inflammatory Intestinal Diseases, 14 Feb. 2025, [Reviewed]
Introduction: This study aimed to develop and validate a burden scale for colonoscopy-specific experiences among patients with inflammatory bowel disease (IBD) and to assess its reliability and validity. Methods: Building upon previous research on patient experiences and perceptions of colonoscopy, a 33-item pain scale was developed. Content validity was assessed to refine the questionnaire. An online survey was conducted through an IBD patient community. The reliability of the scale was evaluated using Cronbach’s α coefficient and test-retest reliability. Validity was examined through factor analysis to assess construct validity and correlation coefficients with external criteria for criterion-related validity. Results: Of the 371 distributed questionnaires, 176 were returned, and data from 173 participants were included in the analysis. Item analysis and exploratory factor analysis yielded a 21-item scale with four distinct factors: pain during colonoscopy, burden with bowel preparation, anxiety and symptoms after colonoscopy, and difficulty in taking time off to receive colonoscopy. The scale demonstrated strong internal consistency (Cronbach’s α = 0.875) and test-retest reliability (intraclass correlation coefficient = 0.879). Criterion-related validity was supported by correlations with external measures, including the cognitive appraisal rating scale (r = 0.615), anxiety related to colonoscopy (r = 0.582), pain during colonoscopy (r = 0.544), and satisfaction with colonoscopy (r = −0.333). Conclusion: The newly developed burden scale for colonoscopy in patients with IBD demonstrated robust reliability and validity, indicating its potential utility as a clinical instrument for assessing the burden in this patient population.

寛解期にある潰瘍性大腸炎患者が抱える疾病に伴う不安　　　　　　　　　　　　　　　
Dec. 2024, [Reviewed]

Construction of an Explanatory Model for Quality of Life in Outpatients with Ulcerative Colitis
Miho Takahashi; Maya Nunotani; Nobuo Aoyama
Inflammatory Intestinal Diseases, 12 Apr. 2023, [Reviewed]
Introduction: To date, no studies have reported explanatory models of health-related quality of life (HRQoL) in patients with ulcerative colitis. Therefore, this study aimed to examine HRQoL and its related factors in outpatients with ulcerative colitis to construct an explanatory model. Methods: We conducted a cross-sectional survey at a clinic in Japan. The HRQoL was evaluated using the 32-item Inflammatory Bowel Disease Questionnaire. We extracted explanatory variables of HRQoL from demographic, physical, psychological, and social factors reported in previous studies and created a predictive explanatory model. The relationship between explanatory variables and the questionnaire total score was examined using Spearman’s rank correlation coefficient, the Mann-Whitney test, or the Kruskal-Wallis test. We conducted multiple regression and path analyses to examine the effect of explanatory variables on the total score. Results: We included 203 patients. Variables that were associated with the total score were the partial Mayo score (r = −0.451), treatment side effects (p = 0.004), the Hospital Anxiety and Depression Scale-Anxiety score (r = −0.678), the Hospital Anxiety and Depression Scale-Depression score (r = −0.528), and the availability of an advisor during difficult times (p = 0.001). The model included the partial Mayo score, treatment side effects, the Hospital Anxiety and Depression Scale-Anxiety score, and the availability of an advisor during difficult times as explanatory variables of the total score that showed the best goodness-of-fit (adjusted R2 = 0.597). The anxiety score exerted the greatest negative effect on the questionnaire total score (β = −0.586), followed by the partial Mayo score (β = −0.373), treatment side effects (β = 0.121), and availability of an advisor during difficult times (β = −0.101). Conclusion: Psychological symptoms exerted the strongest direct effect on HRQoL in outpatients with ulcerative colitis and mediated the relationship between social support and HRQoL. Nurses should listen carefully to the concerns and anxieties of patients to ensure that a social support system is provided by leveraging multidisciplinary collaborations.

Pain with Colonoscopy Experienced by Patients with Inflammatory Bowel Disease
Maya Nunotani; Miho Takahashi
Journal of Japan Academy of Nursing Science, 2023, [Reviewed]

外来通院する潰瘍性大腸炎患者における Quality of life 関連要因の探索とモデル構築　　　　　　　　　　　　　　　
Mar. 2021

N35 Conceptual analysis of disease-related anxiety in ulcerative colitis patients
M Takahashi; M Nunotani
Journal of Crohn's and Colitis, Jan. 2026
Lead, Corresponding

N08 Construction of an explanatory model for quality of life in outpatients with ulcerative colitis
M Takahashi; M Nunotani; N Aoyama
Journal of Crohn's and Colitis, 01 May 2021
Lead, Abstract

Background

Previous studies have reported explanatory models of health-related quality of life (HRQoL) in patients with Crohn disease or inflammatory bowel disease. However, no model for HRQoL has been developed that is specialised for patients with ulcerative colitis (UC). In this study, we aimed to develop and evaluate a predictive explanatory model for HRQoL among outpatients with UC in Japan.

Methods

We conducted a cross-sectional survey between December 2019 and July 2020 at a clinic in Japan. HRQoL was evaluated using the 32-item Inflammatory Bowel Disease Questionnaire (IBDQ-32). We extracted explanatory variables of HRQoL, including disease activity, psychological symptoms, and social support, from previous studies and created an explanatory model based on the conceptual model of Wilson & Cleary (1995). The relationship between explanatory variables and the IBDQ-32 total score was examined using the Spearman’s rank correlation coefficient, Mann–Whitney test, or Kruskal–Wallis test. We conducted multiple regression analysis and path analysis to examine the effect of explanatory variables on IBDQ-32 total score.

Results

We included a total of 203 patients with UC. Variables that were significantly associated with the IBDQ-32 total score were partial Mayo Score, presence or absence of treatment side effects, Hospital Anxiety and Depression Scale (HADS) score, and having/not having an adviser when patients were severely ill-conditioned. HADS had the largest negative effect on IBDQ-32 total score (β = −0.474), followed by partial Mayo Score (β = −0.408), presence/absence of treatment side effects (β = −0.116), having/not having an adviser when patients were ill-conditioned (β = 0.081). Having an adviser or not when ill-conditioned had an indirect effect on patients’ IBDQ-32 total score via HADS (β = −0.111). We verified the final model, which included IBDQ-32 total score and the above four explanatory variables (adjusted R² = 0.501, GFI = 0.996, AGFI = 0.970, CFI = 1.000, RMSEA = 0.010, AIC = 28.043).

Conclusion

Psychological symptoms had the most direct effect on HRQoL in patients with UC and acted as a mediator in the relationship between social support and HRQoL. Nursing interventions to improve HRQoL in patients with UC should consider the effect of psychological symptoms and support when patients are severely ill-conditioned., Oxford University Press (OUP)

N03 Disease burden of patients with inflammatory bowel disease from the viewpoint of QOL and depression
M Takahashi; N Aoyama; M Nunotani
Journal of Crohn's and Colitis, 15 Jan. 2020
Lead, Abstract

Background

Inflammatory bowel disease (IBD) can lead to a decreased quality of life (QOL), and mental care is necessary for patients with IBD. Disease burden (patient burden caused by a disease) attracts attention from the viewpoint of QOL and mental care. However, the relationship between QOL and depression in patients with IBD has not yet been adequately researched. Therefore, we aimed to examine disease burden and the relationship between QOL and depression in Japanese patients with IBD.

Methods

The present study enrolled 200 patients with ulcerative colitis (UC) and 31 patients with Crohn’s disease (CD) who were treated in Aoyama Clinic between July 2018 and September 2018. We evaluated QOL using a 24-item questionnaire which we made originally based on previous studies. Next, we evaluated depression according to the Patient Health Questionnaire-9 (PHQ-9). Partial Mayo score of less than 2 points indicated UC remission, whereas the CDAI score of less than 150 points denoted CD remission. We analysed the difference in QOL and depression scores between UC and CD, the age or sex, the disease activity, and the time since diagnosis using chi-square test. The association between QOL and depression scores was analysed using Spearman’s rank correlation coefficient. This study was approved by the Aoyama Clinic Ethical Review Board (2018-1).

Results

Decrease in QOL (scale ≥ 7) and depression (PHQ-9 score ≥ 10) in active phase were higher than those in remission phase (decrease in QOL among UC in active phase: 6.3 ± 4.8, among UC remission phase: 2.2 ± 3.4; p < 0.05, among CD in active phase: 3.8 ± 3.3, among CD remission phase: 2.3 ± 2.7, depression score among UC in active phase: 4.9 ± 4.8, among UC remission phase: 3.1 ± 3.8; p < 0.05, among CD in active phase: 3.8 ± 3.3, among CD remission phase: 2.3 ± 2.7), but no difference was noted in the age or sex and disease duration. Meanwhile, the QOL decrease and depression score in UC as a whole (r = 0.397, p = 0.000) positively correlated. In remission, the correlation in women (r = 0.385, p = 0.000) was considerably higher than that in men (r = 0.290, p = 0.007). Factors regarding QOL decrease in remission were carcinogenesis, defecation frequency, surgery, economic matters, relapse, lavatory, and heredity.

Conclusion

Even in UC remission and when QOL decrease is mild, women strongly feel a mental burden; thus, they should be given the appropriate care. Disease burden including QOL and mental care is an important point that medical staff and physicians should deal with together., Oxford University Press (OUP)

Conceptual analysis of disease-related anxiety in ulcerative colitis patients
21st Congress of ECCO, 20 Feb. 2026

UC患者が抱える疾病に伴う不安の多施設研究　　　　　　　　　　　　　　　
24 Oct. 2024

Anxiety associated with diseae of patients with ulcerative colitis in remission　　　　　　　　　　　　　　　
Miho Takahashi; Maya Nunotani; Nobuo Aoyama
06 Mar. 2024

UC患者が抱える不安に関する多施設研究　　　　　　　　　　　　　　　
21 Sep. 2023

UC患者の「心理的疾病負荷」における多施設研究について　　　　　　　　　　　　　　　
08 Sep. 2022

UC患者の疾病負荷：今までの研究結果と今後の計画について　　　　　　　　　　　　　　　
02 Sep. 2021

看護師の立場からIBD患者のSDMを考える　　　　　　　　　　　　　　　
24 Aug. 2021

Construction of an explanatory model for quality of life in outpatients with ulcerative colitis　　　　　　　　　　　　　　　
Miho Takahashi; Maya Nunotani; Nobuo Aoyama
26 Jul. 2021

QOL維持・向上に向けたクリニックでのSDMへの取り組み　　　　　　　　　　　　　　　
18 Feb. 2021

Disease burden of patients with inflammatory bowel disease from the viewpoint of QOL and depression　　　　　　　　　　　　　　　
Miho Takahashi; Nobuo Aoyama; Maya Nunotani
21 Feb. 2020

IBD患者のQOL向上を目指したSDMの実践～IBD患者の存在ニーズを看護師としてどう引き出すか　　　　　　　　　　　　　　　
20 Feb. 2020

潰瘍性大腸炎における疾病負荷：QOLとうつ評価　　　　　　　　　　　　　　　
29 Nov. 2019

生物学的製剤について看護師の関わり　　　　　　　　　　　　　　　
19 Oct. 2019

IBD患者のSpecial Situationにおける当院での看護師の関わり　　　　　　　　　　　　　　　
19 Aug. 2019

IBDが心と日常生活に及ぼす影響-看護師としての関わり　　　　　　　　　　　　　　　
07 Mar. 2019

Special SituationにおけるIBD 治療とShared Decision Making　　　　　　　　　　　　　　　
08 Jul. 2018

周産期の看護：妊娠・出産期の看護師の関わり　　　　　　　　　　　　　　　
08 Jul. 2018

妊娠合併IBD患者の診察・Care　　　　　　　　　　　　　　　
17 Sep. 2016

IBD生物学的製剤導入に際しての留意点と看護師対応の実際　　　　　　　　　　　　　　　
26 Jan. 2016

Apr. 2023 - Present
日本難病看護学会　　　　　　　　　　　　　　　

Apr. 2022 - Present
日本看護科学学会　　　　　　　　　　　　　　　

Apr. 2022 - Present
日本炎症性腸疾患学会　　　　　　　　　　　　　　　

May 2016 - Present
日本内視鏡技師学会　　　　　　　　　　　　　　　

Apr. 2000 - Present
日本看護協会　　　　　　　　　　　　　　　

Apr. 2020 - Mar. 2021
European Crohn's and Colitis Organisation　　　　　　　　　　　　　　　

大腸内視鏡検査を受ける炎症性腸疾患患者の苦痛軽減に向けた支援モデルの開発
Apr. 2022 - Mar. 2027

潰瘍性大腸炎患者の疾病に伴う負荷を測定するツールの開発
Apr. 2022 - Mar. 2026