Kazuo Isama
| Faculty of Pharmaceutical Sciences,Department of Pharmaceutical Sciences | Professor |
| Graduate School of Pharmaceutical Sciences,Doctoral Program in Pharmaceutical Sciences | Professor |
Last Updated :2025/10/07
■Researcher basic information
Field Of Study
■Career
Career
■Research activity information
Paper
- Effect of secondary particle size of nickel oxide nanoparticles on cytotoxicity in A549 cells
Tsuyoshi Kawakami; Atsuko Miyajima; Kaoru Komoriya; Reiko Kato; Kazuo Isama
The Journal of Toxicological Sciences, Apr. 2022, [Reviewed] - Potency shift in immunomodulatory activities of zinc oxide (ZnO) nanoparticles in THP-1 cells is associated with cytotoxicity
Atsuko Miyajima; Tsuyoshi Kawakami; Kaoru Komoriya; Reiko Kato; Makoto Usami; Kazuo Isama
Fundamental Toxicological Sciences, Nov. 2021, [Reviewed] - Chromium and Cobalt Concentrations in Textile Products and the Amounts Eluted into Artificial Sweat
Kawakami T; Isama K; Ikarashi Y
Journal of Environmenal Chemistry, Feb. 2020, [Reviewed] - Skin transferability of phthalic acid ester plasticizers and other plasticizers using model polyvinyl chloride sheets.
Tsuyoshi Kawakami; Kazuo Isama; Hideto Jinno
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, 2020
The transferability of phthalic acid esters (PAEs) and other plasticizers, from model polyvinyl chloride (PVC) sheets to the skin of 11 subjects was assessed by measuring the amount of substance transferred using PVC sheets containing PAEs and alternative plasticizers of different types and contents. For all subjects, the transferred amount, from sheets containing 28 wt% PAE or from mixed sheets containing 14 wt% each of di (2-ethylhexyl) phthalate (DEHP) and other PAE, was greater than that from sheets containing 15 wt% each of PAE or alternative plasticizer only. A comparison of the transferability of five types of PAE showed that transfer tended to occur more readily as the n-octanol-water partition coefficient increased, suggesting that PAE hydrophobicity affected its transferability. The transferability of the alternative plasticizers di(2-ethylhexyl) terephthalate and 1,2-cyclohexane dicarboxylic acid diisononyl ester showed a similar trend; however, the transferred amount tended to be higher from model PVC sheets containing 28 wt% PAE or mixed with DEHP. The transferability of PAEs and alternative plasticizers was higher for certain subjects, suggesting individual differences in the transferability of chemicals to the subject's skin surface and is the presence of a group of people comparatively more susceptible to such transfer. - Evaluation of the sensitization potential of volatile and semi-volatile organic compounds using the direct peptide reactivity assay.
Tsuyoshi Kawakami; Kazuo Isama; Yoshiaki Ikarashi; Hideto Jinno
The Journal of toxicological sciences, 2020
The purpose of this study was to evaluate the sensitization potential of 82 compounds classified as volatile and/or semi-volatile organic compounds using the direct peptide reactivity assay (DPRA), given that these chemical compounds have been detected frequently and at high concentrations in a national survey of Japanese indoor air pollution and other studies. The skin sensitization potential of 81 of these compounds was evaluable in our study; one compound co-eluted with cysteine peptide and was therefore not evaluable. Twenty-five of the evaluated compounds were classified as positive. Although all glycols and plasticizers detected frequently and at high concentrations in a national survey of Japanese indoor air pollution were negative, hexanal and nonanal, which are found in fragrances and building materials, tested positive. Monoethanolamine and 1,3-butanediol, which cause clinical contact dermatitis, and several compounds reported to have weak sensitization potential in animal studies, were classified as negative. Thus, it was considered that compounds with weak sensitization potential were evaluated as negative in the DPRA. Although the sensitization potential of the formaldehyde-releasing preservative bronopol has been attributed to the release of formaldehyde (a well-known contact allergen) by its degradation, its degradation products-bromonitromethane and 2-bromoethanol-were classified as positive, indicating that these degradation products also exhibit sensitization potential. The compounds that tested positive in this study should be comprehensively assessed through multiple toxicity and epidemiological studies. - Determination of benzotriazole UV absorbers in textile products made of polyurethane fibers by high-performance liquid chromatography with a photo diode array detector
Kawakami T; Isama K; Ikarashi Y
Journal of Liquid Chromatography & Related Technologies, 2018, [Reviewed] - Hepatotoxicity and Drug/Chemical Interaction Toxicity of Nanoclay Particles in Mice
Katsuhiro Isoda; Ryutaro Nagata; Tomoya Hasegawa; Yuichiro Taira; Ikuko Taira; Yoshimi Shimizu; Kazuo Isama; Tetsuji Nishimura; Isao Ishida
Nanoscale Research Letters, 01 Dec. 2017, [Reviewed] - Effects of different secondary particle sized nickel oxide nanomaterials on cytotoxicity and immune responses
Miyajima-Tabata Atsuko; Kawakami Tsuyoshi; Komoriya Kaoru; Kato Reiko; Haishima Yuji; Isama Kazuo
TOXICOLOGY LETTERS, 20 Oct. 2017, [Reviewed] - Hepatotoxicity and Drug/Chemical Interaction Toxicity of Nanoclay Particles in Mice
Katsuhiro Isoda; Ryutaro Nagata; Tomoya Hasegawa; Yuichiro Taira; Ikuko Taira; Yoshimi Shimizu; Kazuo Isama; Tetsuji Nishimura; Isao Ishida
NANOSCALE RESEARCH LETTERS, Mar. 2017, [Reviewed] - Analysis of glycols, glycol ethers, and other volatile organic compounds present in household water-based hand pump sprays
Tsuyoshi Kawakami; Kazuo Isama; Toshiko Tanaka-Kagawa; Hideto Jinnno
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING, 2017, [Reviewed] - Characterization of alternative plasticizers in poly(vinyl chloride) sheets for blood containers
Yuji Haishima; Tsuyoshi Kawakami; Chie Fukui; Akito Tanoue; Toshiyasu Yuba; Satoru Ozono; Hidehumi Kumada; Kaoru Inoue; Tomomi Morikawa; Miwa Takahashi; Ayano Fujisawa; Kayo Yamasaki; Yusuke Nomura; Kazuo Isama; Ung-il Chung; Kumiko Ogawa; Shingo Niimi; Midori Yoshida
JOURNAL OF VINYL & ADDITIVE TECHNOLOGY, Dec. 2016, [Reviewed] - Effects of different secondary particle sized NiO nanomaterials on the cellular responses
MIYAJIMA Atsuko; KAWAKAMI Tsuyoshi; KOMORIYA Kaoru; KATO Reiko; NIIMI Shingo; ISAMA Kazuo
Annual Meeting of the Japanese Society of Toxicology, 2016 - Survey of isothiazolinones and other preservatives in household wet tissue products in Japan.
KawakamiT; Isama K; Ikarashi Y
Journal of Environmental Chemistry, Dec. 2015, [Reviewed] - Effects of zinc oxide nanomaterials on the cellular responses in vitro
MIYAJIMA Atsuko; KAWAKAMI Tsuyoshi; KOMORIYA Kaoru; KATO Reiko; NIIMI Shingo; ISAMA Kazuo
Annual Meeting of the Japanese Society of Toxicology, 2015 - Cytotoxicity and skin sensitization of phosphite esters
ISAMA Kazuo; KAWAKAMI Tsuyoshi; OBAMA Tomoko; IKARASHI Yoshiaki
Annual Meeting of the Japanese Society of Toxicology, 2015 - Polyploidy induction by spherical size standard polystyrene particles in a Chinese hamster cell line CHL
Atsuko Matsuoka; Agneta Önfelt; Yoshie Matsuda; Kazuo Isama; Hideyuki Sakoda; Reiko Kato; Keiko Sakai; Shingo Niimi
Bulletin of National Institute of Health Sciences, 2015, [Reviewed] - Particle size distribution of aerosols sprayed from household hand-pump sprays containing fluorine-based and silicone-based compounds
Tsuyoshi Kawakami; Kazuo Isama; Yoshiaki Ikarashi
Bulletin of National Institute of Health Sciences, 2015, [Reviewed] - Analysis of 19 preservatives in polyvinyl alcohol cooling towels used in Japan by high performance liquid chromatography with photo diode array detector
Kawakami T; Isama K; Ikarashi Y
J. Environ. Anal. Chem., 2015, [Reviewed] - Development and performance evaluation of a positive reference material for hemolysis testing
Yuji Haishima; Chie Hasegawa; Yusuke Nomura; Tsuyoshi Kawakami; Toshiyasu Yuba; Tomoko Shindo; Keisuke Sakaguchi; Takahiro Tanigawa; Kaori Inukai; Mika Takenouchi; Kazuo Isama; Atsuko Matsuoka; Shingo Niimi
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, Nov. 2014, [Reviewed] - Characteristics and cytotoxic effects of nanoparticles coexisting with metal salts
Kazuo Isama; Tsuyoshi Kawakami; Atsuko Miyajima
TOXICOLOGY LETTERS, Sep. 2014, [Reviewed] - In Vitro Safety Evaluation of Nanomaterials -Cellular Response to Metal Oxide Nanoparticles-
Kazuo Isama
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Jun. 2014, [Reviewed] - Screening study on hemolysis suppression effect of an alternative plasticizer for the development of a novel blood container made of polyvinyl chloride
Yuji Haishima; Tsuyoshi Kawakami; Chie Hasegawa; Akito Tanoue; Toshiyasu Yuba; Kazuo Isama; Atsuko Matsuoka; Shingo Niimi
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, May 2014, [Reviewed] - Study for the Revision of Analytical Method for Tris (2,3-dibromopropyl) phosphate with Restriction in Textiles
Mayumi Mimura; Harunobu Nakashima; Jin Yoshida; Toshiaki Yoshida; Tsuyoshi Kawakami; Kazuo Isama
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Feb. 2014, [Reviewed] - Analysis of isothiazolinone preservatives in polyvinyl alcohol cooling towels used in Japan
Tsuyoshi Kawakami; Kazuo Isama; Yoshiaki Ikarashi
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING, 2014, [Reviewed] - Examination of identification test of certain aromatic amines originating from azo colorants in textile and leather products using high performance liquid chromatography
Tsuyoshi Kawakami; Kazuo Isama; Yoshiaki Ikarashi
Bulletin of National Institute of Health Sciences, 2014, [Reviewed] - A development and biological safety evaluation of novel PVC medical devices with surface structures modified by UV irradiation to suppress plasticizer migration
Yuji Haishima; Kazuo Isama; Chie Hasegawa; Toshiyasu Yuba; Atsuko Matsuoka
Journal of Biomedical Materials Research - Part A, Sep. 2013, [Reviewed] - Calcium-incorporated titanium surfaces influence the osteogenic differentiation of human mesenchymal stem cells.
Sawada R; Kono K; Isama K; Haishima Y; Matsuoka A
Journal of biomedical materials research. Part A, Feb. 2013, [Reviewed] - [Characterization of cases contravening of regulations regarding primary aromatic amines originating from azo dyes in commercial textile products and leather products in European Union].
Kawakami T; Isama K; Ikarashi Y
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, 2013, [Reviewed] - EUにおける繊維および革製品中のアゾ染料由来の特定芳香族アミン類の違反事例の特徴
2013, [Reviewed] - Study on the Degradation of Triphenyltin (TPT) observed in the Process for the Revision of the Official Analytical Method for TPT and Tributyltin (TBT) in Household Products
Tomoko OOSHIMA; Tsuyoshi KAWAKAMI; Tetsuo YAMANO; Asako OZAKI; Mitsuru SHIMIZU; Kazuo ISAMA
Dec. 2012, [Reviewed] - Analysis of isothiazolinones and other preservatives in gel-products used for cooling in Japan.
Tsuyoshi KAWAKAMI; Kazuo ISAMA; Tetsuji NISHIMURA
Journal of Environmental Chemistry, Dec. 2012, [Reviewed] - Survey of primary aromatic amines originating from azo dyes in commercial textile products in direct contact with skin and in commercial leather products in Japan.
Tsuyoshi KAWAKAMI; Kazuo ISAMA; Tetsuji NISHIMURA
Journal of Environmental Chemistry, Dec. 2012, [Reviewed] - Toxicological studies of nano-suspensions of silica, silver and zinc oxide
A. Matsuoka; Y. Kodama; M. Yoshida; K. Isama; K. Inoue; T. Kawakami; A. Nishikawa
24th European Conference on Biomaterials - Annual Conference of the European Society for Biomaterials, 2011 - Osteoblast compatibility of calcium-incorporated Ti-Zr-Nb alloys
Kazuo Isama; Tsuyoshi Kawakami; Toshie Tsuchiya; Atsuko Matsuoka
24th European Conference on Biomaterials - Annual Conference of the European Society for Biomaterials, 2011 - Effects of surface chemistry prepared by self-assembled monolayers on osteoblast behavior
Nakaoka, Ryusuke; Yamakoshi, Yoko; Isama, Kazuo; Tsuchiya, Toshie
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Aug. 2010, [Reviewed] - Determination of Organotin Compounds in Water Soluble Paints and Adhesives by GC-MS
Tsuyoshi Kawakami; Kazuo Isama; Harunobu Nakashima; Tomoko Ooshima; Toshie Tsuchiya; Atsuko Matsuoka
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Feb. 2010, [Reviewed] - Self-Organization of the Compositional Gradient Structure in Hyaluronic Acid and Poly(N-isopropylacrylamide) Blend Film
Bayar Hexig; Kazuo Isama; Yuji Haishima; Yoshio Inoue; Toshie Tsuchiya; Toshihiro Akaike
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2010, [Reviewed] - Gamma-ray Irradiated Poly(L-lactide) for Bone Repair
Kazuo Isama; Toshie Tsuchiya
BIOMATERIALS IN ASIA: IN COMMEMORATION OF THE 1ST ASIAN BIOMATERIALS CONGRESS, 2008, [Reviewed] - Synthesis of a novel beta-tricalcium phosphate/hydroxyapatite biphasic calcium phosphate containing niobium ions and evaluation of its osteogenic properties
Masato Tamai; Kazuo Isama; Ryusuke Nakaoka; Toshie Tsuchiya
JOURNAL OF ARTIFICIAL ORGANS, 2007, [Reviewed] - Novel calcium phosphate ceramics: The remarkable promoting action on the differentiation of the normal human osteoblasts
Masato Tamai; Ryusuke Nakaoka; Kazuo Isama; Toshie Tsuchiya
Key Engineering Materials, 2006 - In vitro induction of polyploidy and chromatid exchanges by culture medium extracts of natural rubbers compounded with 2-mercaptobenzothiazole as a positive control candidate for genotoxicity tests
Atsuko Matsuoka; Kazuo Isama; Toshie Tsuchiya
Journal of Biomedical Materials Research - Part A, 14 Oct. 2005, [Reviewed] - Osteoblast differentiation and apatite formation on gamma-irradiated PLLA sheets
Kazuo Isama; Toshie Tsuchiya
Key Engineering Materials, 2005 - Twenty-Eight Day Repeated Dose Oral Toxicity Test of Synergist of a pyrethroid insecticide, 2, 3, 3, 3, 2′, 3′, 3′, 3′-Octachlorodipropyl ether (S-421) in Rats
Yuko Matsushima; Osayuki Uchida; Minoru Saitoh; Yasushi Kawasaki; Kazuo Isama; Masaaki Kaniwa; Tohru Inoue; Jun Kanno
Bulletin of National Institute of Health Sciences, 2003, [Reviewed] - Enhancing effect of poly(L-lactide) on the differentiation of mouse osteoblast-like MC3T3-E1 cells
Kazuo Isama; Toshie Tsuchiya
Biomaterials, 2003, [Reviewed] - Proliferation and differentiation of normal human osteoblasts on dental Au-Ag-Pd casting alloy: Comparison with cytotoxicity to fibroblast L929 and V79 cells
Kazuo Isama; Atsuko Matsuoka; Yuji Haishima; Toshie Tsuchiya
Materials Transactions, 2002, [Reviewed] - In vivo tissue/biomaterials toxic responses: Correlation with cytotoxic potential but not cell attachment
Toshie Tsuchiya; Yoshiaki Ikarashi; Tadashi Arai; Jynichi Ohhashi; Kazuo Isama; Akitada Nakamura
Clinical Materials, 1994, [Reviewed]
MISC
- Direct peptide reactivity assay(DPRA)を用いた揮発性及び準揮発性有機化合物類の感作性評価
河上強志; 伊佐間和郎; 五十嵐良明; 神野透人
日本薬学会関東支部大会講演要旨集, 10 Sep. 2018 - 繊維製品に含まれるトリス(1-アジリジニル)ホスフィンオキシド(略称:APO)の分析法の改定に向けた検討
味村 真弓; 中島 晴信; 河上 強志; 伊佐間 和郎
日本薬学会年会要旨集, Mar. 2018
(公社)日本薬学会 - 物理化学的性質の異なる酸化亜鉛ナノマテリアルに対するTHP-1の細胞応答
宮島 敦子; 河上 強志; 小森谷 薫; 加藤 玲子; はい島 由二; 伊佐間 和郎
日本薬学会年会要旨集, Mar. 2018
(公社)日本薬学会 - Study for the Revision of Analytical Method for Tris(1-aziridinyl)phosphine oxide in Textiles
味村真弓; 中島晴信; 河上強志; 伊佐間和郎
大阪健康安全基盤研究所研究年報(Web), Feb. 2018 - QCM法による医用高分子材料の血液適合性評価におけるデータ解析手法の検討
伊佐間 和郎; 河上 強志; はい島 由二
日本バイオマテリアル学会大会予稿集, 13 Nov. 2017
日本バイオマテリアル学会 - 亜リン酸エステル系酸化防止剤の刺激性及び感作性と家庭用PVC製手袋中の実態
河上 強志; 秋山 卓美; 伊佐間 和郎; 五十嵐 良明
Journal of Environmental Dermatology and Cutaneous Allergology, 06 Nov. 2017
(一社)日本皮膚アレルギー・接触皮膚炎学会 - Evaluation of skin sensitization potential of guanidine rubber accelerators and their analysis in household rubber products
清水久美子; 秋山卓美; 伊佐間和郎; 河上強志; 五十嵐良明
国立医薬品食品衛生研究所報告, 16 Dec. 2016
国立医薬品食品衛生研究所安全情報部 - シリカ、銀及び酸化亜鉛のナノ分散液のin vitro及びin vivo毒性学的評価
松岡 厚子; 児玉 幸夫; 吉田 緑; 伊佐間 和郎; 中嶋 富士雄; 井上 薫; 河上 強志; 松田 良枝; 五十嵐 良明
国立医薬品食品衛生研究所報告, Dec. 2016
国立医薬品食品衛生研究所安全情報部 - 蛋白質吸着を指標としたQCM法による医用高分子材料の血液適合性評価に関する検討
伊佐間 和郎; 河上 強志; はい島 由二
日本バイオマテリアル学会大会予稿集, Nov. 2016
日本バイオマテリアル学会 - 家庭用防水スプレー製品等による健康被害状況とその安全対策
Mar. 2016, [Invited] - Evaluation of skin sensitization potential of guanidine rubber accelerators and their analysis in household rubber products
Kumiko Shimizu; Takumi Akiyama; Tsuyoshi Kawakami; Kazuo Isama; Yoshiaki Ikarashi
Bulletin of National Institute of Health Sciences, 01 Jan. 2016 - In vitro and in vivo toxicological studies of silica, silver, and zinc oxide nano-suspensions
Atsuko Matsuoka; Yukio Kodama; Midori Yoshida; Kazuo Isama; Fujio Nakajima; Kaoru Inoue; Tsuyoshi Kawakami; Yoshie Matsuda; Yoshiaki Ikarashi
Bulletin of National Institute of Health Sciences, 01 Jan. 2016 - 弾性ストッキング装着時の皮膚障害についての検討
鈴木 加余子; 安藤 亜季; 佐野 晶代; 矢上 晶子; 河上 強志; 伊佐間 和郎; 五十嵐 良明; 佐々木 和実; 松永 佳世子
Journal of Environmental Dermatology and Cutaneous Allergology, Nov. 2015
(一社)日本皮膚アレルギー・接触皮膚炎学会 - Cytotoxicity of phosphite and phosphate triesters
K. Isama; T. Kawakami; Y. Ikarashi
TOXICOLOGY LETTERS, Oct. 2015 - Contact Dermatitis Caused by Isothiazolinone Preservatives : Focusing on Cases of Contact Dermatitis from Household Products
河上 強志; 伊佐間 和郎; 五十嵐 良明
Journal of environmental dermatology and cutaneous allergology, Jul. 2014
日本皮膚アレルギー・接触皮膚炎学会 - DEHP代替可塑剤を利用した新規血液バッグの開発 ラット精巣に及ぼすDOTPの影響評価
Mar. 2014 - Examination of Analytical Method for Triphenyltin (TPT) and Tributyltin (TBT) to Revise the Official Methods Based on "Act on the Control of Household Products Containing Harmful Substances"
Tsuyoshi Kawakami; Kazuo Isama; Harunobu Nakashima; Jin Yoshida; Tomoko Ooshima; Hiroyuki Ohno; Hitoshi Uemura; Hiroko Shioda; Yoko Kikuchi; Atsuko Matsuoka; Tetsuji Nishimura
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Oct. 2012 - Migration of Eight Harmful Elements from Metal Accessories That Infants May Swallow by Mistake
Kazuo Isama; Tsuyoshi Kawakami; Tetsuji Nishimura
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Aug. 2012 - Contact Dermatitis from Dimethyl Fumarate Used as an Anti-Mold Agent
KAWAKAMI Tsuyoshi; ISAMA Kazuo; MATSUOKA Atsuko; NISHIMURA Tetsuji
Journal of environmental dermatology and cutaneous allergology, 31 Jul. 2012
日本皮膚アレルギー・接触皮膚炎学会 - Effect of nanoparticles on the cytotoxicity of coexisting metal salts
Kazuo Isama; Tsuyoshi Kawakami; Keiko Sakai; Atsuko Miyajima; Atsuko Matsuoka
TOXICOLOGY LETTERS, Jun. 2012 - Migration of Eight Harmful Elements from Household Products Made of Synthetic Resin That Infants May Swallow by Mistake
Kazuo Isama; Tsuyoshi Kawakami; Tetsuji Nishimura
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Jul. 2011 - Safety evaluation of nanomaterials used in household products
A. Matsuoka; Y. Kodama; M. Yoshida; K. Isama; F. Nakajima; K. Inoue; T. Kawakami; A. Nishikawa
TOXICOLOGY LETTERS, Jul. 2010 - Analytical Method for Tributyltin and Triphenyltin Contained in Household Products-Preparing for the Revision of Authorized Analytical Method-
Harunobu Nakashima; Ken-ichi Tomiyama; Tsuyoshi Kawakami; Kazuo Isama
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Jul. 2010 - Comparative Study of Acid Extraction Tests of Metal Products Containing Lead
Kazuo Isama; Tsuyoshi Kawakami; Toshie Tsuchiya; Atsuko Matsuoka
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, May 2010 - P-082 Safety Evaluation of Nanomaterials Prepared for Household Products(Poster Presentation)
Matsuoka Atsuko; Kodama Yukio; Yoshida Midori; Isama Kazuo; Nakajima Fujio; Inoue Kaoru; Kawakami Tsuyoshi; Nishikawa Akiyoshi
日本環境変異原学会大会プログラム・要旨集, 2010
日本環境変異原学会 - Capillary electrophoresis research into lead elution from paint films on household products
伊佐間 和郎; 河上 強志; 土屋 利江
Journal of Urban Living and Health Association, 2010
大阪生活衛生協会 - Serious product accidents due to the chemical substances used in household products in fiscal years 2007 and 2008
伊佐間 和郎
Bulletin of National Institute of Health Sciences, 2009
国立医薬品食品衛生研究所安全情報部 - P-070 Cytotoxicity and genotoxicity of eleven size-different polystyrene particles(Poster Session)
Matsuoka Atsuko; Matsuda Yoshie; Isama Kazuo; Tsuchiya Toshie
日本環境変異原学会大会プログラム・要旨集, 2008
日本環境変異原学会 - Analysis of sodium ion, potassium ion and monoethanolamine in alkaline cleaners by capillary electrophoresis
伊佐間 和郎; 鹿庭 正昭; 土屋 利江
Bulletin of National Institute of Health Sciences, 2008
国立医薬品食品衛生研究所安全情報部 - Analysis of tin octylate (tin 2-ethylhexanoate) in polymer materials
中島 晴信; 沢辺 善之; 伊佐間 和郎
大阪府立公衆衛生研究所研究報告, 2008
大阪府立公衆衛生研究所 - P1-039 Cytotoxicity and chromosome aberrations induced by polyurethane model compounds
Matsuoka Atsuko; Isama Kazuo; Matsuda Yoshie; Tanimura Susumu; Kohno Michiaki; Tsuchiya Toshie
日本環境変異原学会大会プログラム・要旨集, 2004
日本環境変異原学会 - 遺伝子発現を指標とする化学物質の安全性評価法に関する研究(平成12年度〜平成14年度)
大野 泰雄; 宇佐見 誠; 小林 哲; 新見 伸吾; 川西 徹; 早川 尭夫; 伊佐間 和郎; 土屋 利江; 佐藤 陽治; 平林 容子; 天野 博夫; 手島 玲子; 中村 亮介; 澤田 純一; 戸田 恭子; 高井 貴子; 林 譲; 中田 琴子; 広瀬 明彦; 江馬 眞; 長谷川 隆一
国立医薬品食品衛生研究所報告, Oct. 2003
国立医薬品食品衛生研究所安全情報部 - In vitro toxicity test of dental casting alloy using normal human osteoblast : Comparison with L929 and V79 cytotoxicity tests.(GENERAL SESSION BY POSTER PRESENTATION)(ENVIRONMENTAL CHEMICALS,HEAVY METALS & CYTOTOXICITY)
ISAMA KAZUO; MATSUOKA ATSUKO; HAISHIMA YUJI; TSUCHIYA TOSHIE
Journal of toxicological sciences, Oct. 2002
The Japanese Society of Toxicology - Change in the Particle Size Distribution of poly(L-lactide) Wear Debris by γ-Ray Irradiation
伊佐間 和郎; 土屋 利枝
Bulletin of National Institute of Health Sciences, 2001
国立医薬品食品衛生研究所化学物質情報部 - インタ-ネットによる家庭用品の安全性に関する情報提供
Jul. 1998 - Analysis of 2-mercaptobenzimidazole type antioxidants in rubber products
K Isama; M Kaniwa; A Nakamura
JAPANESE JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, Apr. 1998 - Studies on safety evaluation of anti-microbial/deodorant agents: Establishment of research method and research results of commercially available products
H Nakashima; Y Ohmori; K Isama; Matsunaga, I; N Miyano; Y Asano; Y Teraji; M Kaniwa
JAPANESE JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, Apr. 1998 - Studies on Safety Evaluation of Antimicrobial and Deodorant Agents : Determination of Antimicrobial Agents and Insecticides in Paper Bag for Electric Vacuum Cleaner
ISAMA K.; KANIWA MASAAKI; NAKAMURA AKITADA
Jpn. J. Toxicol. Environ. Health, 1993
The indications on packages of paper bags for electric vacuum cleaners had antimicrobial agents changed. Benzimidazole and biguanide compounds were newly indicated as antimicrobial agents, and pyrethroid compounds were as insecticides. Thiabendazole and methyl benzimidazolylcarbamate were identified as benzimidazole compounds. In 3 or 2 out of 7 paper bags, these two compounds were determined in the ranges of concentration of 3-513 μg/g and 1-160 μg/g by high performance liquid chromatography (HPLC), respectively. In 1 out of 7 paper bags, as a biguanide compound, chlorhexidine was identified and determined in the concentration of 1300 μg/g by HPLC. On the other hand, in 5 out of 7 paper bags, as a pyrethroid compound, permethrin was identified and determined in the concentration of 82-6310 μg/g by gas chromatography. In most of the paper bags analyzed, larger amounts of these 4 compounds were present in the inner bags than in the outer bags., The Pharmaceutical Society of Japan - CHEMICAL APPROACH TO CONTACT-DERMATITIS CAUSED BY HOUSEHOLD PRODUCTS .8. UV ABSORBER TINUVIN-P IN POLYURETHANE ELASTOMERS FOR FABRIC PRODUCTS
MA KANIWA; K ISAMA; S KOJIMA; A NAKAMURA; K ARISU; R HAYAKAWA
EISEI KAGAKU-JAPANESE JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, Jun. 1991
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