Ikuko Taira
| Faculty of Pharmaceutical Sciences,Department of Pharmaceutical Sciences | Associate Professor |
| Graduate School of Pharmaceutical Sciences,Doctoral Program in Pharmaceutical Sciences | Associate Professor |
Last Updated :2025/10/07
■Researcher basic information
■Career
Career
Educational Background
■Research activity information
Paper
- Potential Anti-Cancer Therapeutic Agents: Effects of VHH Antibodies on Mesothelin Binding Affinity in Cancer
Yoshimi Shimizu; Katsuhiro Isoda; Kaho Shinohara; Miki Nakayama; Ikuko Taira; Yuichiro Taira
BPB Reports, Aug. 2024, [Reviewed] - Anti-tumor effect of a recombinant Bifidobacterium strain secreting a claudin-targeting molecule in a mouse breast cancer model
Yoshimi Shimizu; Katsuhiro Isoda; Yuichiro Taira; Ikuko Taira; Masuo Kondoh; Isao Ishida
European Journal of Pharmacology, 15 Nov. 2020 - 乳がんに対する組換えビフィズス菌の腫瘍集積性と抗腫瘍効果の評価
Aug. 2020 - 組換えビフィズス菌を用いた乳がん治療薬開発に向けた検討
Mar. 2020 - Toxicity of Gold Nanoparticles in Mice due to Nanoparticle/Drug Interaction Induces Acute Kidney Damage
Katsuhiro Isoda; Anju Tanaka; Chisaki Fuzimori; Miyuki Echigoya; Yuichiro Taira; Ikuko Taira; Yoshimi Shimizu; Yoshihiro Akimoto; Hayato Kawakami; Isao Ishida
Nanoscale Research Letters, 2020 - マウスにおける10nm銀ナノ粒子が及ぼす急性肝毒性および薬物/化学物質の相互作用による影響について(Acute hepatotoxicity and drug/chemical interaction toxicity of 10-nm silver nanoparticles in mice)
Isoda Katsuhiro; Kobayashi Naoki; Taira Yuichiro; Taira Ikuko; Shimizu Yoshimi; Akimoto Yoshihiro; Kawakami Hayato; Ishida Isao
Fundamental Toxicological Sciences, Mar. 2019 - 金ナノ粒子の薬物相互作用による傷害性の検討
Mar. 2019 - Reviving Previous Therapeutics by Recombinant Anaerobic Bifidobacteria
Ikuko Taira; Yuichiro Taira; Masakazu Kato; Yoshimi Shimizu; Katuhiro Isoda; Hiromi Saitou; Isao Ishida
Biomedical Journal of Scientific & Technical Research, 09 Jan. 2019, [Reviewed] - The hepatoprotective effect of lycopene on Con A-induced liver injury in mice
Shimizu Y; Mashima-Nemoto T; Hazawa M; Taira Y; Taira I; Ishida I; Isoda K
PHARMAZIE, Jul. 2018, [Reviewed] - [Development of an Anticancer Therapy Using Recombinant Bifidobacterium as a New Drug Delivery System (DDS)].
Taira Y; Taira I; Nisikawa T; Ishida I
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, Jul. 2018, [Reviewed] - Effects of surface charge and palladium on hepatic and kidney injury induced by polystyrene nanoparticles co-administered to mice with paraquat and cisplatin
K. Isoda; T. Nozawa; Y. Taira; I. Taira; Y. Shimizu; I. Ishida
Pharmazie, 2018, [Reviewed] - Hepatotoxicity and Drug/Chemical Interaction Toxicity of Nanoclay Particles in Mice
Katsuhiro Isoda; Ryutaro Nagata; Tomoya Hasegawa; Yuichiro Taira; Ikuko Taira; Yoshimi Shimizu; Kazuo Isama; Tetsuji Nishimura; Isao Ishida
Nanoscale Research Letters, 01 Dec. 2017, [Reviewed] - Influence of nanoclay particles on hepatotoxicity and drug interaction toxicity in mice
Isoda Katsuhiro; Taira Yuichiro; Taira Ikuko; Nishimura Tetsuji; Ishida Isao
TOXICOLOGY LETTERS, 20 Oct. 2017, [Reviewed] - Hepatotoxicity and Drug/Chemical Interaction Toxicity of Nanoclay Particles in Mice
Katsuhiro Isoda; Ryutaro Nagata; Tomoya Hasegawa; Yuichiro Taira; Ikuko Taira; Yoshimi Shimizu; Kazuo Isama; Tetsuji Nishimura; Isao Ishida
NANOSCALE RESEARCH LETTERS, Mar. 2017, [Reviewed] - Hepatotoxicity, nephrotoxicity, and drug/chemical interaction toxicity of platinum nanoparticles in mice
K. Isoda; T. Daibo; K. Yushina; Y. Yoshioka; Y. Tsutsumi; Y. Akimoto; H. Kawakami; Y. Taira; I. Taira; R. Yanoshita; T. Nishimura; I. Ishida
PHARMAZIE, Jan. 2017, [Reviewed] - Influence of polystyrene nanoparticles in inducing cytotoxicity in mice co-injected anti-inflammatory agent, tetracycline or sodium valproate
K. Isoda; Y. Shimizu; Y. Taira; I. Taira; T. Nishimura; I. Ishida
TOXICOLOGY LETTERS, Oct. 2015, [Reviewed] - Potential Role of Voltage-Sensing Phosphatases in Regulation of Cell Structure Through the Production of PI(3,4)P-2
Shinji Yamaguchi; Tatsuki Kurokawa; Ikuko Taira; Naoya Aoki; Souhei Sakata; Yasushi Okamura; Koichi J. Homma
JOURNAL OF CELLULAR PHYSIOLOGY, Apr. 2014, [Reviewed] - Unusual Features of Chick VSP and its Potential Role in Regulation of Cell Structure
Yasushi Okamura; Tatsuki Kurokawa; Shinji Yamaguchi; Naoya Aoki; Ikuko Taira; Souhei Sakata; Koichi Homma
BIOPHYSICAL JOURNAL, Jan. 2012, [Reviewed] - Bioluminescence imaging of c-fos gene expression accompanying filial imprinting in the newly hatched chick brain
Shinji Yamaguchi; Eiji Iikubo; Naoki Hirose; Takaaki Kitajima; Sachiko Katagiri; Ai Kawamori; Ikuko Fujii-Taira; Toshiya Matsushima; Koichi J. Homma
NEUROSCIENCE RESEARCH, Jun. 2010, [Reviewed] - Suppression of the ecdysteroid-triggered growth arrest by a novel Drosophila membrane steroid binding protein
Ikuko Fujii-Taira; Shinji Yamaguchi; Ryoko Iijima; Shunji Natori; Koichi J. Homma
FEBS LETTERS, Feb. 2009, [Reviewed] - Gene expression profile in cerebrum in the filial imprinting of domestic chicks (Gallus gallus domesticus)
Shinji Yamaguchi; Ikuko Fujii-Taira; Sachiko Katagiri; Ei-Ichi Izawa; Yasuyuki Fujimoto; Hideaki Takeuchi; Tatsuya Takano; Toshiya Matsushima; Koichi J. Homma
BRAIN RESEARCH BULLETIN, Jun. 2008, [Reviewed] - Up-regulation of microtubule-associated protein 2 accompanying the filial imprinting of domestic chicks (Gallus gallus domesticus)
Shinji Yamaguchi; Ikuko Fujii-Taira; Akio Murakami; Naoki Hirose; Naoya Aoki; Ei-Ichi Izawa; Yasuyuki Fujimoto; Tatsuya Takano; Toshiya Matsushima; Koichi J. Homma
BRAIN RESEARCH BULLETIN, Jun. 2008, [Reviewed] - The extracellular adenosine deaminase growth factor, ADGF/CECR1, plays a role in Xenopus embryogenesis via the adenosine/P1 receptor
Ryoko Iijima; Takekazu Kunieda; Shinji Yamaguchi; Hiroko Kamigaki; Ikuko Fujii-Taira; Kazuhisa Sekimizu; Takeo Kubo; Shunji Natori; Koichi J. Homma
JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2008, [Reviewed] - Proton pumping ATPases: from single molecule analysis to diverse biological functions
Mayumi Nakanishi-Matsui; Ikuko Fujii-Taira; Masamitsu Futai
SEIKAGAKU, Jun. 2007, [Reviewed] - In-vivo gene transfer into newly hatched chick brain by electroporation
Shinji Yamaguchi; Sachiko Katagiri; Naoki Hirose; Yasuyuki Fujimoto; Masahiro Mori; Ikuko Fujii-Taira; Tatsuya Takano; Toshiya Matsushima; Koichi J. Homma
NEUROREPORT, May 2007, [Reviewed] - Involvement of insect-derived growth factor (IDGF) in the cell growth of an embryonic cell line of flesh fly
Yasuhiro Tanaka; Shinji Yamaguchi; Ikuko Fujii-Taira; Ryoko Iijima; Shunji Natori; Koichi J. Homma
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2006, [Reviewed] - ATP-dependent rotation of mutant ATP synthases defective in proton transport
H Hosokawa; M Nakanishi-Matsui; S Kashiwagi; Fujii-Taira, I; K Hayashi; A Iwamoto-Kihara; Y Wada; M Futai
JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2005, [Reviewed] - Male-specific IDGF, a novel gene encoding a membrane-bound extracellular signaling molecule expressed exclusively in testis of Drosophila melanogaster.
Matsushita T; Fujii-Taira I; Tanaka Y; Homma KJ; Natori S
The Journal of biological chemistry, Nov. 2000, [Reviewed] - Hydrolysis and synthesis of substrate proteins for cathepsin L in the brain. basement membranes of Sarcophaga during metamorphosis
Fujii-Taira, I; Y Tanaka; KJ Homma; S Natori
JOURNAL OF BIOCHEMISTRY, Sep. 2000 - Induction of Sarcophaga central nervous system remodeling by 20-hydroxyecdysone in vitro
Fujii, I; Y Tanaka; K Homma; S Natori
JOURNAL OF BIOCHEMISTRY, Mar. 1999, [Reviewed]
MISC
- 首都圏薬局薬剤師・病院薬剤師における英語ニーズの把握に関する調査
28 Mar. 2025
Lead - 帝京平成大学薬学部1年次生における英語学習に対する感情変化について
Aug. 2024
Last - 帝京平成大学薬学部4年次における英語科目を経た学生の英語学習に対する感情の変化
Mar. 2024
Last - 抗メソテリン-VHH抗体の性状解析とがん細胞株を用いた評価
Mar. 2023 - 抗メソテリン-VHH抗体のイムノトキシン化と中皮細胞株に対する細胞傷害活性の評価
Nov. 2022 - 抗メソテリン-VHH抗体のイムノトキシン化と中皮細胞株に対する細胞傷害活性の評価
Nov. 2022 - メソテリンの立体構造を認識する抗メソテリン-VHH抗体の精製と性状解析
Nov. 2021 - 偏性嫌気性細菌を用いたトリプルネガティブ乳がん治療薬の開発
Mar. 2021 - 乳がんに対する組換えビフィズス菌の腫瘍集積性と抗腫瘍効果の評価
Aug. 2020 - 銀ナノワイヤーの薬物相互作用に関する検討
Mar. 2020 - EPR効果増強剤によるビフィズス菌腫瘍内集積数の増大
Mar. 2019 - CL4指向性抗腫瘍蛋白質を分泌する組換えビフィズス菌の作製
榎本健太; 清水芳実; 山内友梨奈; 平裕一郎; 平郁子; 磯田勝広; 斎藤浩美; 石田功
日本薬学会関東支部大会講演要旨集, 10 Sep. 2018 - がんターゲティング療法の最前線 組換えビフィズス菌をDDS(ドラッグデリバリーシステム)として用いたがん治療法の開発
平 裕一郎; 平 郁子; 西川 毅; 石田 功
薬学雑誌, Jul. 2018
(公社)日本薬学会 - PVP修飾銀ナノ粒子の医薬品に対する安全性に関する検討
望月 優摩; 小野 壮平; 磯田 勝広; 平 裕一郎; 平 郁子; 石田 功
日本薬学会年会要旨集, Mar. 2018
(公社)日本薬学会 - TNF-α発現・分泌組換えビフィズス菌のマウス悪性黒色腫モデルを用いたがん免疫療法への応用検討
加藤 雅和; 平 裕一郎; 平 郁子; 清水 芳実; 磯田 勝広; 斎藤 浩美; 石田 功
日本薬学会年会要旨集, Mar. 2018
(公社)日本薬学会 - ビフィズス菌の蛋白質発現量向上に向けたプロモーターの探索と体内動態解析
清水 芳実; 榎本 健太; 磯田 勝広; 平 裕一郎; 平 郁子; 斎藤 浩美; 石田 功
日本薬学会年会要旨集, Mar. 2018
(公社)日本薬学会 - TNF-α発現・分泌組換えビフィズス菌のマウス悪性黒色腫モデルを用いたがん免疫療法への応用検討
Mar. 2018 - ビフィズス菌の蛋白質発現量向上に向けたプロモーターの探索と体内動態解析
Mar. 2018 - PVP修飾銀ナノ粒子の医薬品に対する安全性に関する検討
Mar. 2018 - Development of an Anticancer Therapy Using Recombinant Bifidobacterium as a New Drug Delivery System (DDS)
Taira Yuichiro; Taira Ikuko; Nisikawa Takeshi; Ishida Isao
YAKUGAKU ZASSHI, 2018
The Pharmaceutical Society of Japan - TNF‐α発現・分泌組換えビフィズス菌の構築及び抗腫瘍効果の検討
加藤雅和; 平裕一郎; 平郁子; 竹澤玲美; 中井亮佑; 清水芳実; 磯田勝広; 斎藤浩美; 石田功
日本薬学会関東支部大会講演要旨集, 10 Sep. 2017 - 粒子径による銀ナノ粒子の傷害性と薬物相互作用に関する検討
青木 幸菜; 磯田 勝広; 上田 舞子; 小林 直樹; 平 郁子; 平 裕一郎; 石田 功
日本薬学会年会要旨集, Mar. 2017
(公社)日本薬学会 - がんターゲティング療法の最前線 組換えビフィズス菌をDDS(ドラッグデリバリーシステム)として用いた癌治療法の開発
平 裕一郎; 平 郁子; 西川 毅; 石田 功
日本薬学会年会要旨集, Mar. 2017
(公社)日本薬学会 - 粒子径10nm銀ナノ粒子の安全性評価に関する検討
小林 尚樹; 磯田 勝広; 長谷川 知也; 秋元 義弘; 平 裕一郎; 平 郁子; 石田 功
日本薬学会年会要旨集, Mar. 2016
(公社)日本薬学会 - TRAIL-R1を標的とした新規3価VHH抗体を分泌するビフィズス菌によるがん治療
西川 毅; 平 裕一郎; 平 郁子; 斎藤 浩美; 磯田 勝広; 石田 功
日本薬学会年会要旨集, Mar. 2016
(公社)日本薬学会 - ナノ白金粒子の単回投与毒性と薬物相互作用の検討
磯田勝広; 大坊萌美; 油科香里; 平裕一郎; 平郁子; 吉岡靖雄; 堤康央; 石田功
Journal of Toxicological Sciences, Jun. 2015
The Japanese Society of Toxicology - 抗TRAIL受容体アゴニスト一本鎖抗体発現・分泌ビフィズス菌の抗腫瘍効果の解析
平 裕一郎; 西川 毅; 平 郁子; Akter Jesmin; 磯田 勝広; 斎藤 浩美; 石田 功
日本DDS学会学術集会プログラム予稿集, Jun. 2015
日本DDS学会 - Effect of toxicity and drug interactions by nano-platinum particles
ISODA Katsuhiro; DAIBO Tomomi; YUSHINA Kaori; TAIRA Yuitiro; TAIRA Ikuko; YOSHIOKA Yasuo; TSUTSUMI Yasuo; ISHIDA Isao
Annual Meeting of the Japanese Society of Toxicology, Jun. 2015
日本毒性学会 - 細胞死誘導抗体を分泌するビフィズス菌を利用したがん治療
西川 毅; 平 裕一郎; 平 郁子; 斎藤 浩美; 礒田 勝広; 石田 功
日本薬学会年会要旨集, Mar. 2015
(公社)日本薬学会 - 嫌気性菌をDDSに用いた固形がんに対する新規治療法の開発
平 裕一郎; 平 郁子; 大野 まき; 西川 毅; 磯田 勝広; 池本 守; 斎藤 浩美; 石田 功
日本薬学会年会要旨集, Mar. 2014
(公社)日本薬学会 - 嫌気性菌をドラッグデリバリー担体に用いた固形がんに対する新規治療法の開発―in vivoレベルでの解析
平裕一郎; 平郁子; 大野まき; 西川毅; 磯田勝広; 池本守; 斎藤浩美; 石田功
日本薬学会関東支部大会講演要旨集, 15 Oct. 2013 - 嫌気性菌をドラッグデリバリー担体に用いた固形がんに対する新規治療法の開発―細胞・分子レベルでの解析
西川毅; 平裕一郎; 平郁子; 大野まき; 磯田勝広; 池本守; 斎藤浩美; 石田功
日本薬学会関東支部大会講演要旨集, 15 Oct. 2013 - 薬学教育シリアスゲームのモチベーションに与えるランキングの影響
平 郁子; 頭島 武; 齋藤 充生; 石井 竹夫; 林 譲
日本薬学会年会要旨集, Mar. 2012
(公社)日本薬学会 - Manufacture and Trial of Educational Software named Mentor and Kuthrill for Pharmaceutical Sciences
齋藤 充生; 平 郁子; 頭島 武; 石井 竹夫; イシイ タケオ; Ishii Takeo; 林 譲; ハヤシ ユズル; Hayashi Yuzuru
帝京平成大学紀要, Mar. 2012
Because of the demand for more highly skilled pharmacists and the introduction of 6-year pharmacist education, an effective learning system is required in the pharmaceutical school. To provide enjoyable self-teaching educational materials, we developed two serious games called Mentor and Kuthrill. The former is an electronic workbook in the state examination for the pharmacist's license with a face-based indicator. The latter is a Tetris type puzzle game designed to teach correct combinations of drug names and pharmacological categories. Both games are designed for students to acquire pharmaceutical knowledge while gaming without stress. The gaming time and score are recorded automatically. In this study, graduate research students were nominated as monitors. They played games under actual circumstances and the learning curves of scores and play times were analyzed. Both games were effective in most cases, though benefits were ambiguous in some cases. Further research is required to develop more useful serious games., 帝京平成大学 - 23年度長期実務実習にむけて 学生アンケート調査より
Mar. 2011 - Characterizations of chick voltage-sensing phosphatase and its possible role in regulation of cell structure
Yasushi Okamura; Shinji Yamaguchi; Ikuko Taira; Tatsuki Kurokawa; Naoya Aoki; Souhei Sakata; Kouichi Homma
NEUROSCIENCE RESEARCH, 2011 - Physiological genomics of voltage-sensing phosphatases
Yasushi Okamura; Tatsuki Kurokawa; Souhei Sakata; Ikuko Fujii-Taira; Yoshifumi Okochi; Shinji Yamaguchi; Michio Ogasawara; Koichi J. Homma
JOURNAL OF PHYSIOLOGICAL SCIENCES, 2010 - 鳥類刻印付けにおける細胞骨格制御因子Microtubule‐Associated Protein2(MAP2)の解析
片桐幸子; 山口真二; 平郁子; 松島俊也; 本間光一
生化学, 25 Sep. 2009 - 破骨細胞におけるV-ATPase a3サブユニット局在オルガネラの解析
松元 奈緒美; 中西 真弓; 松井; 平 郁子; 二井 將光
日本生化学会大会プログラム・講演要旨集, Sep. 2009
(公社)日本生化学会 - ニワトリVSPはホスファターゼ活性の発現によって線維芽細胞の形態変化を引き起こす
平 郁子; 山口 真二; 山田 マミ; 神垣 ひろこ; 黒川 竜紀; 岡村 康司
日本生化学会大会プログラム・講演要旨集, Sep. 2009
(公社)日本生化学会 - 鳥類刻印付けの分子基盤の解明
片桐幸子; 山口真二; 平郁子; 本間光一
ファーマ・バイオフォーラム2008要旨集, Nov. 2008 - RNAiによるニワトリヒナ大脳での特異的遺伝子発現抑圧系の確立
片桐 幸子; 山口 真二; 平 郁子; 廣瀬 直樹; 神垣 ひろこ; 松島 俊也; 高野 達哉; 本間 光一
日本薬学会年会要旨集, Mar. 2008
(公社)日本薬学会 - Proton pumping V-ATPase in osteoclast forming resorption lacuna
平 郁子; 中西 真弓; 二井 将光
生体の科学, May 2007
金原一郎記念医学医療振興財団 - センチニクバエ分泌型カテプシンLの変態時における脳再編成への関与
01 Aug. 1996
Books and other publications
Affiliated academic society
Research Themes
- 抗Ras抗体分泌ビフィズス菌を用いた新規癌治療法の開発
01 Apr. 2021 - 31 Mar. 2024 - The development of the drug delivery system via recombinant bifidobacteria aiming for an anti-cancer TNF-alpha preparation without adverse side effects.
Grant-in-Aid for Scientific Research (C)
Teikyo Heisei University
Apr. 2019 - Mar. 2023 - The application of the drug delivery system by recombinant bifidobacteria to overcome the weak point of the low-molecule anticancer STAT3 inhibitors.
Grant-in-Aid for Scientific Research (C)
Teikyo Heisei University
01 Apr. 2018 - 31 Mar. 2021
In this study, we generated recombinant bifidobacteria that secrete an membrane-permeable anti-STAT3 antibody protein. This recombinant bifidobacteria showed strong antitumor effects in vitro and in vivo against various cancer cells. Therefore, we believe that this recombinant bifidobacteria may be one of the potential antitumor agents with DDS that inhibits STAT3 activity. - 抗腫瘍低分子STAT3阻害剤の弱点の克服に向けた組み換えビフィズス菌DDSの応用
2018 - 2020 - Development of the novel therapy against pancreatic cancer using highly absorbable curcumin preparation and recombinant bifidobacteria.
Grant-in-Aid for Scientific Research (C)
Teikyo Heisei University
Apr. 2015 - Mar. 2019
Theracurmin is a curcumin oral preparation having enhanced absorbability that inhibits NF-kappaB activity and exhibits high safety and favorable prognosis in clinical studies on pancreatic cancer patients. In this study, we found that the anti-tumor activity of recombinant bifidobacteria, secreting TNF-alpha or agonistic antibodies against TRAIL-R1, was elevated by concomitant use of those recombinant bacteria and the oral administration of theracurmin. - 医薬品リバイバル技術による創薬イノベーション
Apr. 2014 - Mar. 2019 - 嫌気性菌をドラッグデリバリー担体に用いた固形がんに対する新規治療法の開発
2012 - 2014 - The analyses of the function of the axon guidance molecules in the filial imprinting of chick
Grant-in-Aid for Young Scientists (Start-up)
Teikyo University
2008 - 2009
We analyzed the gene-expression of Netrin-1 using the brain of newly hatched chick. As the result, we identified the Intermediate Medial Hyperpallium Apicale (IMHA) as the novel region related to filial imprinting.
When the vector for the expression of microRNA besed on the sequence of microtubule-associated protein (MAP2) gene introduced to the region related to filial imprinting, endogenious MAP2 protein was decreased, and memory formation was inhibited during filial imprinting.
Industrial Property Rights
- 特許第6176683号, 特願2015-556763, 組換え偏性嫌気性グラム陽性菌
- WO2015-104994, JP2014084038, 組換え偏性嫌気性グラム陽性菌
- WO2015-104994, JP2014084038, 組換え偏性嫌気性グラム陽性菌
