Shoichi Komine
| Faculty of Health Care,Department of Acupuncture and Moxibustion | Lecturer |
| Graduate School of Health Sciences,Master's and Doctoral Programs in Acupuncture and Moxibustion | Lecturer |
Last Updated :2025/10/28
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Paper
- Effect of Electroacupuncture on Delayed-Onset Muscle Soreness Induced by Eccentric Exercise in Young Untrained Men
Shoichi Komine; Ikuru Miura; Teng Hu; Akihiro Ogata; Shinsuke Tamai; Katsuyuki Tokinoya; Sechang Oh; Shota Wada; Kazuhiro Takekoshi; Go Ito; Tomonori Isobe; Takashi Matsui; Hajime Ohmori
American Journal of Physical Medicine & Rehabilitation, Aug. 2025, [Reviewed] - Effects of electrical acupuncture stimulation on the exercise endurance and muscle glycogen concentration of the Tibialis Anterior muscle of mice
Ritsuko Komine; Shoichi Komine; Kei Ebina; Kai Aoki; Katsuyuki Tokinoya; YasushiKawakami; Kazuhiro Takekoshi
International Journal of Analytical Bio-Science., Dec. 2024, [Reviewed] - Exploring Feasibility of fNIRS to Assess Delayed Inhibition Effect of Prefrontal Cortex for Acute Stress by Acupuncture on GV20: A Pilot Study
Hideaki Tamai; Shoichi Komine; Senichiro Kikuchi; Hideaki Waki
Frontiers in Human Neuroscience, Nov. 2024, [Reviewed] - Effects of Electroacupuncture Stimulation on the Expressions of Clock Genes in the Skeletal Muscle of Mice.
Ritsuko Komine; Shoichi Komine; Norio Ishida; Yasushi Kawakami; Kazuhiro Takekoshi
International Journal of Analytical Bio-Science, Oct. 2024, [Reviewed] - Muscle Quality as a Potential Diagnostic Marker of Advanced Liver Fibrosis in Patients with Non-alcoholic Fatty Liver Disease.
Natsumi Oshida; Sechang Oh; Bokun Kim; Ikuru Miura; Naoyuki Hasegawa; Shoichi Komine; Tomonori Isobe; Junichi Shoda
Journal of obesity & metabolic syndrome, 30 Jun. 2024, [Reviewed]
BACKGROUND: Muscle-liver crosstalk plays an important role in the development and progression of non-alcoholic fatty liver disease (NAFLD). The measurement of muscle echo-intensity during ultrasonography is a real-time, non-invasive method of assessing muscle quality. In this retrospective study, we investigated the significance of poor muscle quality (namely, a greater mass of non-contractile tissue, including intramuscular fat) as a risk factor for advanced liver fibrosis and considered whether it may represent a useful tool for the diagnosis of advanced liver fibrosis. METHODS: We analyzed data from 307 patients with NAFLD (143 men and 164 women) who visited the University of Tsukuba Hospital between 2017 and 2022. The patients were stratified into the following tertiles of muscle quality according to their muscle echo-intensity on ultrasonography: modest (84.1 arbitrary units [A.U.]), intermediate (97.4 A.U.), and poor (113.6 A.U.). We then investigated the relationships between muscle quality and risk factors for advanced liver fibrosis and calculated appropriate cutoff values. RESULTS: Patients with poor muscle quality showed a significant, 7.6-fold greater risk of liver fibrosis compared to those with modest muscle quality. Receiver operating characteristic curve analysis showed that muscle quality assessment was as accurate as the fibrosis-4 index and NAFLD fibrosis score in screening for liver fibrosis and superior to the assessment of muscle quantity and strength, respectively. Importantly, a muscle echo-intensity of ≥92.4 A.U. may represent a useful marker of advanced liver fibrosis. CONCLUSION: Muscle quality may represent a useful means of identifying advanced liver fibrosis, and its assessment may become a useful screening tool in daily practice. - Effect of Electroacupuncture on Delayed-Onset Muscle Soreness Induced by Eccentric Exercise in Young Untrained Men: Comparison of Contralateral and Ipsilateral Stimulation
Shoichi Komine; Ikuru Miura; Teng Hu; Akihiro Ogata; Shinsuke Tamai; Katsuyuki Tokinoya; Takehito Sugasawa; Sechang Oh; Shota Wada; Kazuhiro Takekoshi; Go Ito; Tomonori Isobe; Takashi Matsui; Hajime Ohmori
23 Apr. 2024, [Reviewed]
Background: Electroacupuncture stimulation is sometimes used to prevent and treat delayed onset muscle soreness (DOMS) induced by exercise; however, the effect is unclear. Using a human biceps brachii muscle pain induction model, we investigated the effect of contralateral electroacupuncture (CEA) versus ipsilateral electroacupuncture (IEA) stimulation on DOMS and muscle injury markers. Methods: Nineteen young men were randomly assigned to receive either CEA or IEA. All participants performed eccentric exercise using the biceps brachii muscle of the nondominant arm to induce muscle damage. Electroacupuncture stimulation (1.5 Hz, 15 minutes) was applied to the dominant arm in the CEA group and the nondominant arm in the IEA group. Electroacupuncture stimulation was applied in both groups from 7 days before exercise to 4 days after exercise. All variables were analyzed at the following seven timepoints: baseline, immediately before exercise, immediately after exercise, and on days 1–4 after exercise. Results: Palpation pain was significantly lower in the IEA group than the CEA group at 72 and 96 hours after exercise. The decrease in the elbow range of motion after exercise was significantly suppressed by electroacupuncture stimulation. The muscle injury markers (creatine kinase, lactate dehydrogenase) increased following exercise, but these changes were not significantly influenced by IEA stimulation. IEA suppressed exercise-induced oxidative stress at 72 hours after exercise. Conclusion: This study suggests that the application of IEA before and after eccentric exercise effectively reduces DOMS. Electroacupuncture might suppress increases in oxidative stress elicited by eccentric exercise. - Macrophage specific restoration of the Nrf2 gene in whole-body knockout mice ameliorates steatohepatitis induced by lipopolysaccharide from Porphyromonas gingivalis through enhanced hepatic clearance.
Kanako Chihara; Kosuke Okada; Fumihiko Uchida; Ikuru Miura; Shoichi Komine; Eiji Warabi; Takako Takayama; Hideo Suzuki; Takashi Matsuzaka; Naomi Ishibashi-Kanno; Kenji Yamagata; Toru Yanagawa; Hiroki Bukawa; Junichi Shoda
PloS one, 2023, [Reviewed]
Lipopolysaccharide (LPS) derived from Porphyromonas gingivalis (P.g.), which causes periodontal disease, contributes to the development of non-alcoholic steatohepatitis (NASH). We investigated the role of Nrf2, an antioxidative stress sensor, in macrophages in the development of NASH induced by LPS from P.g. We generated macrophage-specific Nrf2 gene rescue mice (Nrf2-mRes), which express Nrf2 only in macrophages, using the cre/loxp system. Wild-type (WT) mice, whole body Nrf2-knockout (Nrf2-KO) mice, and Nrf2-mRes mice were fed a high-fat diet for 18 weeks, and LPS from P.g. was administered intraperitoneally for the last 6 weeks. Nrf2-KO mice developed severe steatohepatitis with liver inflammation and fibrosis compared with WT mice, and steatohepatitis was ameliorated in Nrf2-mRes mice. The mRNA expressions of Toll-like receptor (Tlr)-2, which activates inflammatory signaling pathways after LPS binding, and α-smooth muscle actin (αSma), which promotes hepatic fibrosis, were reduced in Nrf2-mRes mice compared with Nrf2-KO mice. The protein levels of LPS-binding protein in livers were increased in Nrf2-KO mice compared with WT mice; however, the levels were reduced in Nrf2-mRes mice despite similar numbers of F4/80 positive cells, which reflect macrophage/Kupffer cell infiltration into the livers. Nrf2 in macrophages ameliorates NASH through the increased hepatic clearance of LPS. - Improvement of low-intensity long-time running performance in rats by intake of glucosyl hesperidin.
Suminori Nagayama; Kai Aoki; Shoichi Komine; Norie Arai; Shin Endo; Hajime Ohmori
Physiological reports, Jan. 2023, [Reviewed]
Recently, the use of ergogenic aids in sports by both athletes and fans has increased. Moreover, the overall demand for new ergogenic aids has increased. Hesperidin is a polyphenol that is useful for improving exercise performance by activating energy generation through β-oxidation and oxidative phosphorylation in skeletal muscles. However, it is difficult to use this compound as an ergogenic aid because of its poor water solubility and low bioavailability. Glucosyl hesperidin is formed when one molecule of glucose is transferred to hesperidin via glycosyl-transferase. It is 10,000× more soluble and has 3.7× higher bioavailability than hesperidin. In this study, we assessed whether continuous (14 days) intake of glucosyl hesperidin improves the aerobic exercise capacity of rats during long-term acute exercise. Although glucosyl hesperidin intake did not improve the performance of high-intensity running (30 m/min), we did observe improvement in low-intensity running (15 m/min) (p < 0.05). We demonstrate that in sedentary rats, glucosyl hesperidin intake increased β-oxidation and oxidative phosphorylation in the skeletal muscle (p < 0.05 and p < 0.01, respectively). Glucosyl hesperidin intake may have created a metabolic state useful for long-term exercise. In conclusion, the continuous intake of glucosyl hesperidin improved the aerobic exercise capacity of rats during long-term acute exercise. - Taurine supplementation enhances endurance capacity by delaying blood glucose decline during prolonged exercise in rats
Shoichi Komine; Teruo Miyazaki; Keisuke Ishikura; Takashi Matsui; Takashi Miyoshi; Song-Gyu Ra; Akira Honda; Hideaki Soya; Shumpei Miyakaw; Hajime Ohmori
Amino Acids, Feb. 2022, [Reviewed]Abstract Taurine enhances physical performance; however, the underlying mechanism remains unclear. This study examined the effect of taurine on the overtime dynamics of blood glucose concentration (BGC) during endurance exercise in rats. Male F344 rats were subjected to transient treadmill exercise until exhaustion following 3 weeks of taurine supplementation or non-supplementation (TAU and CON groups). Every 10 min during exercise, BGC was measured in blood collected through cannulation of the jugular vein. Gluconeogenesis-, lipolysis-, and fatty acid oxidation-related factors in the plasma, liver, and skeletal muscles were also analyzed after 120-min run. Exercise time to exhaustion was significantly longer with taurine supplementation. BGC in the two groups significantly increased by 40 min and gradually and significantly decreased toward the respective exhaustion point. The decline in BGC from the peak at 40 min was significantly slower in the TAU group. The time when the once-increased BGC regressed to the 0-time level was significantly and positively correlated with exercise time until exhaustion. At the 120-min point, where the difference in BGC between the two groups was most significant, plasma free fatty acid concentration and acetyl-carnitine andN -acetyltaurine concentrations in skeletal muscle were significantly higher in the TAU group, whereas glycogen and glucogenic amino acid concentrations and G6Pase activity in the liver were not different between the two groups. Taurine supplementation enhances endurance capacity by delaying the decrease in BGC toward exhaustion through increases of lipolysis in adipose tissues and fatty acid oxidation in skeletal muscles during endurance exercise. - Effect of a sulforaphane supplement on muscle soreness and damage induced by eccentric exercise in young adults: A pilot study
Shoichi Komine; Ikuru Miura; Nao Miyashita; Sechang Oh; Katsuyuki Tokinoya; Junichi Shoda; Hajime Ohmori
Physiological Reports, Dec. 2021, [Reviewed] - N-acetyltaurine and Acetylcarnitine Production for the Mitochondrial Acetyl-CoA Regulation in Skeletal Muscles during Endurance Exercises.
Teruo Miyazaki; Yuho Nakamura-Shinya; Kei Ebina; Shoichi Komine; Song-Gyu Ra; Keisuke Ishikura; Hajime Ohmori; Akira Honda
Metabolites, 06 Aug. 2021, [Reviewed]
During endurance exercises, a large amount of mitochondrial acetyl-CoA is produced in skeletal muscles from lipids, and the excess acetyl-CoA suppresses the metabolic flux from glycolysis to the TCA cycle. This study evaluated the hypothesis that taurine and carnitine act as a buffer of the acetyl moiety of mitochondrial acetyl-CoA derived from the short- and long-chain fatty acids of skeletal muscles during endurance exercises. In human subjects, the serum concentrations of acetylated forms of taurine (NAT) and carnitine (ACT), which are the metabolites of acetyl-CoA buffering, significantly increased after a full marathon. In the culture medium of primary human skeletal muscle cells, NAT and ACT concentrations significantly increased when they were cultured with taurine and acetate or with carnitine and palmitic acid, respectively. The increase in the mitochondrial acetyl-CoA/free CoA ratio induced by acetate and palmitic acid was suppressed by taurine and carnitine, respectively. Elevations of NAT and ACT in the blood of humans during endurance exercises might serve the buffering of the acetyl-moiety in mitochondria by taurine and carnitine, respectively. The results suggest that blood levels of NAT and ACT indicate energy production status from fatty acids in the skeletal muscles of humans undergoing endurance exercise. - Prevention of non‐alcoholic steatohepatitis by long‐term exercise via the induction of phenotypic changes in Kupffer cells of hyperphagic obese mice
Ikuru Miura; Shoichi Komine; Kosuke Okada; Shota Wada; Eiji Warabi; Fumihiko Uchida; Sechang Oh; Hideo Suzuki; Yuji Mizokami; Junichi Shoda
Physiological Reports, 15 May 2021, [Reviewed]
Exercise ameliorates nonalcoholic fatty liver disease (NAFLD) by inducing phenotypic changes in Kupffer cells (KCs). p62/Sqstm1-knockout (p62-KO) mice develop NAFLD alongside hyperphagia-induced obesity. We evaluated (1) the effects of long-term exercise on the foreign-body phagocytic capacity of KCs, their surface marker expression, and the production of steroid hormones in p62-KO mice; and (2) whether long-term exercise prevented the development of non-alcoholic steatohepatitis (NASH) in p62-KO mice fed a high-fat diet (HFD). In experiment 1, 30-week-old male p62-KO mice were allocated to resting (p62-KO-Rest) or exercise (p62-KO-Ex) groups, and the latter performed long-term exercise over 4 weeks. Then, the phenotype of their KCs was compared to that of p62-KO-Rest and wild-type (WT) mice. In experiment 2, 5-week-old male p62-KO mice that were fed a HFD performed long-term exercise over 12 weeks. In experiment 1, the phagocytic capacity of KCs and the proportion of CD68-positive cells were lower in the p62-KO-Rest group than in the WT group, but they increased with long-term exercise. The percentage of CD11b-positive KCs was higher in the p62-KO-Rest group than in the WT group, but lower in the p62-KO-Ex group. The circulating dehydroepiandrosterone (DHEA) concentration was higher in p62-KO-Ex mice than in p62-KO-Rest mice. In experiment 2, the body mass and composition of the p62-KO-Rest and p62-KO-Ex groups were similar, but the hepatomegaly, hepatic inflammation, and fibrosis were less marked in p62-KO-Ex mice. The DHEA concentration was higher in p62-KO-Ex mice than in WT or p62-KO-Rest mice. Thus, long-term exercise restores the impaired phagocytic capacity of KCs in NAFLD obese mice, potentially through greater DHEA production, and prevents the development of NASH by ameliorating hepatic inflammation and fibrogenesis. These results suggest a molecular mechanism for the beneficial effect of exercise in the management of patients with NAFLD. - An Antioxidant Nanoparticle Enhances Exercise Performance in Rat High‐intensity Running Models
Takuto Toriumi; Ahram Kim; Shoichi Komine; Ikuru Miura; Suminori Nagayama; Hajime Ohmori; Yukio Nagasaki
Advanced Healthcare Materials, May 2021, [Reviewed] - The Production of a Rat Model That Inhibits Phosphoenolpyruvate Carboxykinase (PEPCK), a Rate-Limiting Enzyme of Hepatic Gluconeogenesis.
Hajime Ohmori; Masataka Matsumura; Shoichi Komine; Haruki Kobayashi; Yusei Kobayashi; Jun Shiromoto; Sumpei Miyakawa
Advances in experimental medicine and biology, Aug. 2019, [Reviewed]
We previously showed that taurine administration contributed to the extension of time to exhaustion through exercise-induced hypoglycemia restraint, and we suggested that the activation of hepatic gluconeogenesis was initiated before the exercise with the taurine administration. We hypothesize that the extension effect of exercise duration with the taurine administration is restrained in the rats which inhibited hepatic gluconeogenesis. In this study, we aimed to produce a rat model that inhibited hepatic gluconeogenesis as a first step in testing our hypothesis.F344 male rats of 8 weeks after birth were purchased. The blood samples were collected via jugular vein catheter to perform the pyruvate tolerance test (PTT) with the intraperitoneal administration, and to determine the optimal time point of blood glucose measurement. 3-mercaptopicolinic acids (3MPA) was used as an inhibitor of PEPCK. The rats were divided into three groups, Non-dosage control (CON) group, 30 mg/kg・BW 3MPA (3MPA 30) group, and 300 mg/kg・BW 3MPA (3MPA 300) group.The blood glucose level showed a significant peak 15 min after pyruvate administration. The change of the blood glucose level after the PTT in 3MPA 300 group was significantly smaller than that of the CON group at this time point. These results show we could prepare the rat model that inhibited hepatic gluconeogenesis. - Effect of BCAA supplement timing on exercise-induced muscle soreness and damage: a pilot placebo-controlled double-blind study.
Song-Gyu Ra; Teruo Miyazaki; Ryo Kojima; Shoichi Komine; Keisuke Ishikura; Kentaro Kawanaka; Akira Honda; Yasushi Matsuzaki; Hajime Ohmori
The Journal of sports medicine and physical fitness, Nov. 2018, [Reviewed]
BACKGROUND: The aim of the present study was to compare the effects of branched-chain amino acid (BCAA) supplementation taken before or after exercise on delayed onset muscle soreness (DOMS) and exercise-induced muscle damage (EIMD). METHODS: Fifteen young men (aged 21.5±0.4 years) were given either BCAA (9.6 g·day-1) or placebo before and after exercise (and for 3 days prior to and following the exercise day) in three independent groups: the control group (placebo before and after exercise), the PRE group (BCAA before exercise and placebo after exercise), and the POST group (placebo before exercise and BCAA after exercise). Participants performed 30 repetitions of eccentric exercise with the non-dominant arm. DOMS, upper arm circumference (CIR), elbow range of motion (ROM), serum creatine kinase (CK), lactate dehydrogenase (LDH), and aldolase, BCAA, and β-hydroxy-β-methylbutyrate (3HMB) were measured immediately before and after the exercise and on the following 4 days. RESULTS: Serum BCAA and 3HMB concentrations increased significantly in the PRE group immediately after the exercise, recovering to baseline over the following days. In the days following the exercise day, DOMS, CIR, and ROM were significantly improved in the PRE group compared to the control group, with weaker effects in the POST group. Serum activities of CK, LDH, and aldolase in the days following the exercise day were significantly suppressed in the PRE group compared to control group. CONCLUSIONS: The present study confirmed that repeated BCAA supplementation before exercise had a more beneficial effect in attenuating DOMS and EIMD induced by eccentric exercise than repeated supplementation after exercise. - 分岐鎖アミノ酸（BCAA）投与がマラソン後の血清C反応性タンパク質濃度ならびに血漿グルタミン濃度に及ぼす効果．
Mar. 2018, [Reviewed], [Invited] - Nuclear factor (erythroid derived 2)-like 2 activation increases exercise endurance capacity via redox modulation in skeletal muscles
Sechang Oh; Shoichi Komine; Eiji Warabi; Kentaro Akiyama; Akiko Ishii; Kazunori Ishige; Yuji Mizokami; Keisuke Kuga; Masaki Horie; Yoshihiro Miwa; Takao Iwawaki; Masayuki Yamamoto; Junichi Shoda
SCIENTIFIC REPORTS, Oct. 2017, [Reviewed] - Exercise training enhances in vivo clearance of endotoxin and attenuates inflammatory responses by potentiating Kupffer cell phagocytosis
Shoichi Komine; Kentaro Akiyama; Eiji Warabi; Sechang Oh; Keisuke Kuga; Kazunori Ishige; Shinji Togashi; Toru Yanagawa; Junichi Shoda
SCIENTIFIC REPORTS, Sep. 2017, [Reviewed] - Cytoprotective Role of Nrf2 in Electrical Pulse Stimulated C2C12 Myotube
Masaki Horie; Eiji Warabi; Shoichi Komine; Sechang Oh; Junichi Shoda
PLOS ONE, Dec. 2015, [Reviewed] - Increased N-Acetyltaurine in Serum and Urine After Endurance Exercise in Human
Teruo Miyazaki; Keisuke Ishikura; Akira Honda; Song-Gyu Ra; Shoichi Komine; Yasunori Miyamoto; Hajime Ohmori; Yasushi Matsuzaki
TAURINE 9, Apr. 2015, [Reviewed] - Combined effect of branched-chain amino acids and taurine supplementation on delayed onset muscle soreness and muscle damage in high-intensity eccentric exercise
Song-Gyu Ra; Teruo Miyazaki; Keisuke Ishikura; Hisashi Nagayama; Shoichi Komine; Yoshio Nakata; Seiji Maeda; Yasushi Matsuzaki; Hajime Ohmori
Journal of the International Society of Sports Nutrition, 06 Nov. 2013, [Reviewed]
MISC
- 一過性レジスタンス運動後の血中タウリン濃度の経時的変化
Sep. 2020 - タウリンが胃粘膜正常細胞とそのがん様変異株の増殖に及ぼす影響
Sep. 2020 - 継続的走運動は高脂肪食摂餌p62遺伝子欠失マウスにおける脂肪性肝炎を改善する
Oct. 2019 - 慢性肝疾患における筋損傷マーカーTitin N-fragmentの尿中測定とその臨床的意義
Nov. 2018 - 過食肥満マウスにおける継続的走運動はKupffer細胞の異物貪食能の増大と形質変化を誘導する
Nov. 2018 - 肝糖新生酵素ホスホエノールピルビン酸カルボキシキナーゼを阻害したラットモデルの作製．
松村正隆; 小峰昇一; 小林春輝; 小林雄晟; 城本淳; 宮川俊平; 大森, 肇
タウリンリサーチ, Sep. 2018 - 継続的運動はDHEA産生増加を介して、Kupffer細胞(KC)貪食能の向上によるLPSに対する生体クリアランス増大と炎症応答の低下を誘導する
Sep. 2017 - スルフォラファンによる転写因子Nrf2の賦活化が運動耐容能に与える影響
Jun. 2017 - 継続的な運動負荷がエンドトキシンのクリアランスと炎症応答に与える影響
Jun. 2017 - 運動はDHEA産生を介して、Kupffer細胞貪食能の向上によるLPSのクリアランス増大、また、炎症応答の低下を誘導する
Apr. 2017 - Are reduced taurine levels in the white adipose tissue of obese mice improved by endurance training?
Kei Ebina; Daisuke Yamamoto; Keisuke Ishikura; Shoichi Komine; Teruo Miyazaki; T Ohno; Shumpei Miyakawa; Hajime Ohmori
Journal of Physical Fitness and Sports Medicine, Nov. 2016 - 継続的な運動はKupffer細胞の異物貪食能の増大により、菌体内毒素(LPS)のクリアランスを増大させ、LPS刺激による炎症応答を低下させる
Oct. 2016 - フルマラソンにおける速発性筋痛および筋損傷の特徴
Dec. 2015 - 持続的な骨格筋収縮時の酸化ストレス動態と抗酸化ストレス因子Nrf2の役割
Dec. 2015 - 経験の違いがフルマラソン後の筋損傷・炎症マーカーならびに筋肉痛に及ぼす影響
Dec. 2015 - 運動実践の継続はKupffer細胞の異物貪食能を増加させる
Dec. 2015 - 長時間運動時の遊離アミノ酸の動態にタウリン投与が及ぼす影響
海老名慧; 小峰昇一; 大野貴弘; 時野谷勝幸; 石倉惠介; 松井崇; 羅成圭; 宮崎照雄; 宮川俊平; 征矢英昭; 大森肇
体力科学, Dec. 2015
(一社)日本体力医学会 - B-3-4 Differences in delayed and immediate onset muscle soreness and damage induced by eccentric exercise and a full-marathon(The Proceedings of the 23rd Annual Meetings of Japan Society of Exercise and Sports Physiology July 25・26, (Tokyo)) :
Tokinoya Katsuyuki; Ishikura Keisuke; Komine Shoichi; Ebina Kei; Ra Song-Gyu; Miyazaki Teruo; Miyakawa Shumpei; Ohmori Hajime
Advances in exercise and sports physiology, 2015
Japan Society of Exercise and Sports Physiology - 運動様式の違いによって生じる遅発性と速発性の筋痛・筋損傷の違い~伸張性運動とフルマラソンによる検討~
時野谷勝幸; 石倉惠介; 小峰昇一; 海老名慧; 羅成圭; 宮崎照雄; 宮川俊平; 大森肇
日本運動生理学会大会プログラム・抄録集, 2015 - タウリン投与による長時間運動時の血糖維持~遊離アミノ酸を基質とした糖新生の検討~
海老名慧; 小峰昇一; 大野貴弘; 時野谷勝幸; 石倉惠介; 松井崇; 羅成圭; 宮崎照雄; 宮川俊平; 征矢英昭; 大森肇
日本運動生理学会大会プログラム・抄録集, 2015 - 肥満予防を目的とした全身振動刺激の有用性の基礎的検討
Dec. 2014 - 運動による肝・骨格筋におけるNrf2活性化の解析
Dec. 2014 - 転写因子Nrf2は高脂肪食による肝脂肪蓄積を抑止し、運動実践はNrf2活性化を介して肝脂肪蓄積を改善する
Jun. 2014 - 1-A-8 Effect of BCAA supplement timing on the attenuation of DOMS(The Proceedings of the 21st Annual Meetings of Japan Society of Exercise and Sports Physiology July 27 ・ 28, (Saitama)) :
RA Song-Gyu; KOMINE Shoichi; ISHIKURA Keisuke; MIYAKAWA Shumpei; MIYAZAKI Teruo; OHMORI Hajime
Advances in exercise and sports physiology, 2013
Japan Society of Exercise and Sports Physiology - 1-B-4 Effect of taurine supplementation on the blood glucose level during the endurance exercise in rats(The Proceedings of the 21st Annual Meetings of Japan Society of Exercise and Sports Physiology July 27 ・ 28, (Saitama)) :
KOMINE Shoichi; ISHIKURA Keisuke; MATSUI Takashi; Ra Song-Gyu; MIYAZAKI Teruo; MIYAKAWA Shumpei; SOYA Hideaki; OHMORI Hajime
Advances in exercise and sports physiology, 2013
Japan Society of Exercise and Sports Physiology - 長時間運動中の血糖低下をタウリン投与により抑制するラットモデルの作製
小峰昇一; 石倉恵介; 鈴木隆文; 松井崇; 羅成圭; 宮崎照雄; 宮川俊平; 征矢英昭; 大森肇
体力科学, Dec. 2012
(一社)日本体力医学会 - 長期の運動トレーニングによるラット骨格筋HSP72発現増加に抗酸化物質投与が及ぼす影響
鈴木隆文; 小峰昇一; 宮崎照雄; 石倉恵介; 中彩乃; 松阪賢; 宮川俊平; 島野仁; 大森肇
体力科学, Dec. 2012
(一社)日本体力医学会 - Influence of increased blood ammonia by long duration running on the performance of calculation task
Hajime Ohmori; Daisuke Aoki; Keisuke Ishikura; Song-Gyu Ra; Takafumi Suzuki; Shoichi Komine; Michio Okido; Teruo Miyazaki
AMINO ACIDS, Jul. 2011
Lectures, oral presentations, etc.
- Self-assembling polymer antioxidants amazingly improve exercise performance
Takuto Toriumi; Ahram Kim; Shoichi Komine; Ikuru Miura; Suminori Nagayama; Hajime Ohmori; Yukio Nagasaki
3rd G’L’owing Polymer Symposium in KANTO, 28 Nov. 2020 - 自己組織化抗酸化剤は高強度走行時間を大幅に延長する
27 Nov. 2020 - Effects of electro acupuncture on muscle soreness and muscle damage
Komine S; Miura I; Wada S; Tamai S; Yamamoto K; Ogata A; Itho G; Matsui T; Ohmori H
The 25th Annual congress of the European College of Sport Science, 28 Oct. 2020 - 高血中滞留性を持つ新規抗酸化剤による高強度走行への影響
26 Sep. 2020 - スルフォラファン摂取がヒトの伸長性運動により誘発される筋痛・筋損傷に与える効果
26 Sep. 2020 - 血中活性酸素種を除去する抗酸化ナノメディシンの設計と運動能力向上効果
25 Sep. 2020 - 自己組織化抗酸化薬が高強度走行に及ぼす影響
16 Sep. 2020 - Effects of glucosyl hesperidin intake on aerobic exercise capacity in rats.
Nagayama S; Komine S; Arai N; Endo S; Ohmori S
The 7th International Conference on Food Factors (ICoFF 2019), 04 Dec. 2019 - Design and evaluation of antioxidant-nanoparticle for improving exercise performance.
Toriumi T; Kim A; Komine S; Miura I; Nagayama S; Ohmori H; Nagasaki Y
2nd GLowing Polymer Symposium in KANTO (GPS-K 2019), 30 Nov. 2019 - 抗酸化ナノメディシンによる運動能力向上効果の検証
26 Nov. 2019 - 抗酸化ナノメディシンによる運動能力向上のメカニズムの解明
21 Nov. 2019 - 自己組織化抗酸化薬による運動能力向上の評価
15 Oct. 2019 - 長時間体内滞留性を有する抗酸化ナノ粒子の投与がラット走行時間に及ぼす影響．
28 Sep. 2019 - Is taking sulforaphane effective for eccentric exercise-induced muscle soreness and muscle damage in humans?
Miura I; Komine S; Miyashita N; Tokinoya K; Konno M; Kawazu S; Ohmori H
The 24th Annual congress of the European College of Sport Science, 04 Jul. 2019 - ブロッコリースプラウト抽出物の摂取は伸長性運動後の酸化ストレスを抑制する．
28 Jun. 2019 - 運動能力向上を目指した抗酸化ナノメディシンの設計と評価．
27 Jun. 2019 - 伸張性運動が血中タウリン濃度に与える影響
05 Mar. 2019 - ８週間の高脂肪食に伴う肥満化が肝臓・白色脂肪組織のタウリン合成能に及ぼす影響
05 Mar. 2019 - 慢性肝疾患における筋損傷マーカーTitin N-fragmentの尿中測定とその臨床的意義．
07 Dec. 2018 - 過食肥満マウスにおける継続的走運動はKupffer細胞の異物貪食能の増大と形質変化を誘導する．
07 Dec. 2018 - タウリン投与が血中インスリン濃度および血糖値に与える影響．
18 Sep. 2018 - 肝糖新生酵素ホスホエノールピルビン酸カルボキシキナーゼを阻害したラットモデルの作製．
16 Sep. 2018 - タウリン投与が長時間運動時の骨格筋におけるβ酸化に及ぼす影響 -血中アセチルカルニチンによる検討-
06 Aug. 2018 - Does a fitness training class make mood states in university students better? -An assessment by using the Profile of Mood States and salivary chromogranin A-.
Morita S; Komine S; Kurita S; Tokinoya K; Shiromoto J; Sugasawa T; Nanmoku T; Takekoshi K; Kogo Y; Sakamoto A; Ohmori H
第7回生命機能研究会, 06 Aug. 2018 - 肝糖新生酵素ホスホエノールピルビン酸カルボキシキナーゼを阻害したラットモデルの作製．
04 Mar. 2018 - 継続的運動はDHEA産生増加を介して，Kupffer細胞（KC）貪食能の向上によるLPSに対する生体クリアランス増大と炎症応答の低下を誘導する．
13 Oct. 2017 - Nuclear factor (erythroid derived 2)-like 2 activation increases exercise endurance capability through redox-modulation of skeletal muscles in mice.
Oh S; Komine S; Akiyama K; Shoda J
International Conference on Oral;Maxillofacial Surgery, 31 Aug. 2017 - 継続的な運動負荷がエンドトキシンのクリアランスと炎症応答に与える影響．
12 Jul. 2017 - スルフォラファンによる転写因子Nrf2の不活化が運動耐容能に与える影響．
12 Jul. 2017 - 継続的運動はDHEA産生によりKupffer細胞(KCs)の貪食能を向上させ，生体のLPSクリアランス増大と炎症応答の低下を誘導する．
28 Jun. 2017 - スルフォラファンによる転写因子Nrf2の賦活化は，運動耐容能を向上させる．
28 Jun. 2017 - 運動はDHEA産生を介してKupffer細胞貪食能の向上によるLPSのクリアランス増大，また，炎症応答の低下を誘導する．
09 Jun. 2017 - 運動はDHEA産生によりKupffer細胞貪食能を向上させ，生体のLPSクリアランス増大と炎症応答の低下を誘導する．
19 Apr. 2017 - Is the decreased taurine synthesis in the white adipose tissue of the obese mice restored by exercise training?
Ohmori H; Mizushima T; Yamamoto D; Ishikura K; Ebina K; Komine S; Miyazaki T; Miyakawa S
ARIHHP Human High Performance International Forum 2017, 07 Mar. 2017 - Does a fitness training class make mood states in university students better? - An assessment by using Profile of Mood State and salivary chromogranin A -
Morita S; Komine S; Kurita S; Tokinoya K; Sugasawa T; Shiromoto J; Nanmoku T; Takekoshi K; Kogo Y; Sakamoto A; Ohmori H
第21回静岡健康・長寿学術フォーラム, 25 Nov. 2016 - 長時間運動時の血糖低下をタウリン投与が抑制する機序 -ピルビン酸負荷試験による糖新生能の検討-．
25 Nov. 2016 - マウスの白色脂肪組織中タウリン濃度に及ぼす肥満と持久性トレーニングの影響．
25 Sep. 2016 - 継続的な運動負荷は菌体内毒素（LPS）クリアランスを増大させ，LPS刺激による炎症応答を低下させる．
24 Sep. 2016 - 長時間運動時の血糖低下をタウリン投与が抑制する機序 -肝糖新生に着目して-．
06 Aug. 2016 - Is the lower taurine levels in the white adipose tissue of the obese mice ameliorated by endurance training?
Ohmori H; Yamamoto D; Ebina K; Ishikura K; Komine S; Miyazaki T; Ono T; Miyakawa S
The 20th International Taurine meeting, 26 May 2016 - The effect of taurine supplementation on beta-oxidation in skeletal muscle during prolonged exercise -examination using serum acetyl-carnitine-.
Mizushima T; Miyazaki T; Ebina K; Ishikura K; Ono T; Komine S; Nakamura Y; Tokinoya K; Yamamoto D; Honda A; Matsuzaki Y; Miyakawa S; Ohmori H
The 20th International Taurine meeting, 25 May 2016 - Is the lowering of taurine levels in the white adipose tissue of the obese mice improved by endurance training?
Ohmori H; Yamamoto D; Ebina K; Ishikura K; Komine S; Miyazaki T; Ono T; Miyakawa S
Human High Performance International Forum 2016, 17 Mar. 2016 - マラソン誘発性筋損傷と炎症に対する分岐鎖アミノ酸投与の抑制効果．
12 Mar. 2016 - 肥満マウスの白色脂肪組織におけるタウリン濃度の低下は持久性トレーニングで抑制されるか．
06 Mar. 2016 - L-シトルリン投与がラットの走運動パフォーマンスに及ぼす影響〜中強度運動と高強度運動での比較〜．
20 Sep. 2015 - 運動実践の継続はKupffer細胞の異物貪食能を増加させる．
19 Sep. 2015 - 長時間運動時の遊離アミノ酸の動態にタウリン投与が及ぼす影響．
19 Sep. 2015 - フルマラソンにおける遅発性筋痛および筋損傷の特徴
18 Sep. 2015 - 長時間運動時の遊離アミノ酸の動態にタウリン投与が及ぼす影響．
17 Sep. 2015 - 経験の違いがフルマラソン後の筋損傷・炎症マーカーならびに筋肉痛に及ぼす影響．
17 Sep. 2015 - 運動様式の違いによって生じる遅発性と速発性の筋痛・筋損傷の違い〜伸張性運動とフルマラソンによる検討〜．
26 Jul. 2015 - 長時間運動時の血糖低下をタウリン投与が抑制する機序〜遊離アミノ酸を基質とした糖新生からの検討〜．
25 Jul. 2015 - 持久性運動によるアセチルタウリンの生成．
22 Feb. 2015 - 長時間運動時の血糖低下をタウリン投与が抑制する機序〜遊離アミノ酸を基質とした糖新生からの検討〜．
21 Feb. 2015 - 分岐鎖アミノ酸投与がフルマラソン後の酸化ストレス，抗酸化力へ及ぼす影響．
20 Sep. 2014 - 肥満予防を目的とした全身振動刺激の有用性の基礎的検討.
20 Sep. 2014 - 運動による肝・骨格筋におけるNrf2活性化の解析．
19 Sep. 2014 - Increased N-acetyltaurine in serum and urine after endurance exercise in human.
Miyazaki T; Ishikura K; Honda A; Ra SG; Komine S; Ohmori H; Matsuzaki Y
The 19th International Taurine Meeting, 24 May 2014 - Taurine supplementation suppresses hypoglycemia and increases endurance running time in rats.
Komine S; Miyosi T; Matsui T; Ishikura K; Ra SG; Miyazaki T; Shoda J; Soya H; Ohmori H
The 19th International Taurine Meeting, 23 May 2014 - Effects of taurine supplementation on change of blood glucose and liver glycogen during and after exhaustive running.
Ohmori H; Miyosi T; Komine S; Matsui T; Ishikura K; Ra SG; Miyazaki T; Soya H; Miyakawa S
The 19th International Taurine Meeting, 23 May 2014 - 写因子Nrf2は高脂肪食による肝脂肪蓄積を抑止し，運動実践はNrf2活性化を介して肝脂肪蓄積を改善する．
08 Mar. 2014 - タウリン投与が走運動時の糖新生関連酵素に及ぼす影響．
21 Sep. 2013 - 分岐鎖アミノ酸投与がフルマラソン誘発性の血漿遊離アミノ酸濃度変化に及ぼす影響．
21 Sep. 2013 - 長時間走行の持続時間と血糖値へのタウリン投与の影響
27 Jul. 2013 - 長時間運動時の血糖低下をタウリン投与により抑制するラットモデルの作製．
15 Sep. 2012 - 成長が異なる筋線維組成の骨格筋アミノ酸濃度変化に及ぼす影響．
15 Sep. 2012 - 運動後のラット骨格筋アミノ酸濃度に及ぼすタウリン投与の影響と濃度依存性.
17 Sep. 2011 - Influence of increased blood ammonia by long duration running on the performance of calculation task.
Ohmori H; Aoki D; Ishikura K; Ra SG; Suzuki T; Komine S; Okido M; Miyazaki T
The 12th International Congress on Amino Acids, Peptides and Proteins, 04 Aug. 2011
Affiliated academic society
Research Themes
- 農村部住民に向けた生活習慣病予防食育プロジェクト
Apr. 2025 - Mar. 2028 - 体力向上のための運動実践やセルフケアを継続するサイトレス指導システムの基盤構築
Apr. 2024 - Mar. 2028 - 骨格筋への鍼通電刺激が時計遺伝子に与える影響とそれに関連する遺伝子の網羅探索
Apr. 2025 - Mar. 2027 - A study of nutritional counseling that combines the urinary natrium-kalium ratio with a survey of Na and K intakes
Grant-in-Aid for Scientific Research (C)
Teikyo Heisei University
Apr. 2024 - Mar. 2027 - Is blood cfDNA after exercise loading concentration a predictor of DOMS level immediately ?
Grant-in-Aid for Scientific Research (C)
Teikyo Heisei University
Apr. 2024 - Mar. 2027 - Role of Muscle Nrf2 in Exercise-Induced NASH Improvement - Focusing on EVs
Grant-in-Aid for Scientific Research (B)
R Professional University of Rehabilitation
Apr. 2023 - Mar. 2026 - 鍼通電刺激がオープンウィンドウ現象に与える影響と随伴する上気道感染の予防効果検証
Apr. 2022 - Mar. 2025 - 伸張性収縮による骨格筋損傷モデルを用いた，鍼治療効果の検討
Nov. 2021 - Jun. 2022 - Nrf2の賦活化は，運動負荷誘発性の酸化ストレス応答を制御し，筋疲労・筋損傷を抑制する
Apr. 2019 - Mar. 2022 - 一過性運動負荷前の鍼通電が運動後の遅発性筋痛・筋損傷に与える影響
Jun. 2019 - Mar. 2020 - Nrf2の賦活化は，運動負荷誘発性の酸化ストレス応答を制御し，筋疲労・筋損傷を抑制する
Sep. 2018 - Mar. 2019 - The effect of taurine supplementation on maintenance of blood glucose level during prolonged exercise
Grant-in-Aid for Scientific Research (C)
University of Tsukuba
2011 - 2013
In this study, it was first clarified that taurine supplementation inhibited hypoglycemia at the last phase of prolonged exercise and it strongly influenced increment of the exhaustion time. There was a possibility that taurine supplementation induced activation of gluconeogenic enzymes and supplied an available situation for gluconeogenesis in the liver before exercise. It was also speculated that amino acids derived from skeletal muscles might involve the hepatic gluconeogenesis as substrates.
