Shin'ichiro Yamamoto
| Faculty of Pharmaceutical Sciences,Department of Pharmaceutical Sciences | Associate Professor |
Last Updated :2025/06/19
■Researcher basic information
■Career
Career
- Apr. 2018 - Present
Teikyo Heisei University, Faculty of Pharmaceutical Sciences, 准教授 - Sep. 2015 - Mar. 2018
Teikyo Heisei University, Faculty of Pharmaceutical Sciences, 講師 - Apr. 2014 - Aug. 2015
The University of Tokushima, Faculty of Pharmaceutical Sciences, 助教 - Apr. 2009 - Mar. 2014
Kyoto University, Faculty of Pharmaceutical Sciences, 助教
Educational Background
■Research activity information
Paper
- Dynamic remodeling of TRPC5 channel-caveolin-1-eNOS protein assembly potentiates the positive feedback interaction between Ca2+ and NO signals.
Reiko Sakaguchi; Nobuaki Takahashi; Takashi Yoshida; Nozomi Ogawa; Yoshifumi Ueda; Satoshi Hamano; Kaori Yamaguchi; Seishiro Sawamura; Shinichiro Yamamoto; Yuji Hara; Tomoya Kawamoto; Ryosuke Suzuki; Akito Nakao; Masayuki X Mori; Tetsushi Furukawa; Shunichi Shimizu; Ryuji Inoue; Yasuo Mori
The Journal of biological chemistry, 21 Aug. 2024 - Mouse transient receptor potential melastatin 2 (TRPM2) isoform 7 attenuates full-length mouse TRPM2 activity through reductions in its expression by targeting it to ER-associated degradation.
Shinichiro Yamamoto; Naoto Kiyatake; Akihiro Kaneko; Masanao Shimamura; Takashi Yoshida; Shunichi Shimizu
Genes to cells : devoted to molecular & cellular mechanisms, Mar. 2024, [Reviewed]
Lead, Corresponding - Possible involvement of TRPM2 activation in 5-fluorouracil-induced myelosuppression in mice
Masaaki Ishibashi; Masakazu Ishii; Shinichiro Yamamoto; Yasuo Mori; Shunichi Shimizu
European Journal of Pharmacology, Jan. 2021, [Reviewed] - Functional maintenance of calcium store by ShcB adaptor protein in cerebellar Purkinje cells.
Sho Kakizawa; Yasushi Kishimoto; Shinichiro Yamamoto; Kazuko Onga; Kunihiko Yasuda; Yoshiaki Miyamoto; Masahiko Watanabe; Ryuichi Sakai; Nozomu Mori
Scientific reports, 02 Sep. 2020, [Reviewed] - Short TRPM2 prevents the targeting of full-length TRPM2 to the surface transmembrane by hijacking to ER associated degradation.
Shinichiro Yamamoto; Takahiro Ishii; Ryota Mikami; Tomohiro Numata; Shunichi Shimizu
Biochemical and biophysical research communications, Dec. 2019, [Reviewed]
Lead, Corresponding - Protective Effects of Duloxetine against Cerebral Ischemia-Reperfusion Injury via Transient Receptor Potential Melastatin 2 Inhibition.
Takahiro Toda; Shinichiro Yamamoto; Noriko Umehara; Yasuo Mori; Minoru Wakamori; Shunichi Shimizu
The Journal of pharmacology and experimental therapeutics, Feb. 2019, [Reviewed] - Tyrphostin AG-related compounds attenuate H2O2-induced TRPM2-dependent and -independent cellular responses.
Shinichiro Yamamoto; Takahiro Toda; Ryo Yonezawa; Takaharu Negoro; Shunichi Shimizu
Journal of pharmacological sciences, May 2017, [Reviewed]
Lead - Significance of TRP channels in oxidative stress.
Shinichiro Yamamoto; Shunichi Shimizu
European journal of pharmacology, 15 Dec. 2016, [Reviewed]
Lead - Targeting TRPM2 in ROS-Coupled Diseases.
Shinichiro Yamamoto; Shunichi Shimizu
Pharmaceuticals (Basel, Switzerland), 07 Sep. 2016, [Reviewed]
Lead - Inhibitory effects of Tyrphostin AG-related compounds on oxidative stress-sensitive transient receptor potential channel activation.
Takahiro Toda; Shinichiro Yamamoto; Ryo Yonezawa; Yasuo Mori; Shunichi Shimizu
European journal of pharmacology, 05 Sep. 2016, [Reviewed] - TRPM2 channels in alveolar epithelial cells mediate bleomycin-induced lung inflammation.
Ryo Yonezawa; Shinichiro Yamamoto; Miki Takenaka; Yukiko Kage; Takaharu Negoro; Takahiro Toda; Masayuki Ohbayashi; Tomohiro Numata; Yasuko Nakano; Toshinori Yamamoto; Yasuo Mori; Masakazu Ishii; Shunichi Shimizu
Free radical biology & medicine, Jan. 2016, [Reviewed] - Sensitization of H2O2-induced TRPM2 activation and subsequent interleukin-8 (CXCL8) production by intracellular Fe(2+) in human monocytic U937 cells.
Shunichi Shimizu; Ryo Yonezawa; Takaharu Negoro; Shinichiro Yamamoto; Tomohiro Numata; Masakazu Ishii; Yasuo Mori; Takahiro Toda
The international journal of biochemistry & cell biology, Nov. 2015, [Reviewed] - Prevention of aberrant protein aggregation by anchoring the molecular chaperone αB-crystallin to the endoplasmic reticulum.
Shinichiro Yamamoto; Arisa Yamashita; Naokatu Arakaki; Hisao Nemoto; Tetsuo Yamazaki
Biochemical and biophysical research communications, 12 Dec. 2014, [Reviewed]
Lead - Contribution of calumin to embryogenesis through participation in the endoplasmic reticulum-associated degradation activity.
Shinichiro Yamamoto; Tetsuo Yamazaki; Shinji Komazaki; Takeshi Yamashita; Masako Osaki; Masaya Matsubayashi; Hiroyasu Kidoya; Nobuyuki Takakura; Daiju Yamazaki; Sho Kakizawa
Developmental biology, 01 Sep. 2014, [Reviewed]
Lead, Corresponding - TRIM50 protein regulates vesicular trafficking for acid secretion in gastric parietal cells.
Miyuki Nishi; Fumiyo Aoyama; Fumihiko Kisa; Hua Zhu; Mingzhai Sun; Peihui Lin; Hiroya Ohta; Bo Van; Shinichiro Yamamoto; Sho Kakizawa; Hideki Sakai; Jianjie Ma; Akira Sawaguchi; Hiroshi Takeshima
The Journal of biological chemistry, 28 Sep. 2012, [Reviewed] - The juvenile myoclonic epilepsy-related protein EFHC1 interacts with the redox-sensitive TRPM2 channel linked to cell death.
Masahiro Katano; Tomohiro Numata; Kripamoy Aguan; Yuji Hara; Shigeki Kiyonaka; Shinichiro Yamamoto; Takafumi Miki; Seishiro Sawamura; Toshimitsu Suzuki; Kazuhiro Yamakawa; Yasuo Mori
Cell calcium, Feb. 2012, [Reviewed] - TRPA1 underlies a sensing mechanism for O2.
Nobuaki Takahashi; Tomoyuki Kuwaki; Shigeki Kiyonaka; Tomohiro Numata; Daisuke Kozai; Yusuke Mizuno; Shinichiro Yamamoto; Shinji Naito; Ellen Knevels; Peter Carmeliet; Toru Oga; Shuji Kaneko; Seiji Suga; Toshiki Nokami; Jun-ichi Yoshida; Yasuo Mori
Nature chemical biology, 28 Aug. 2011, [Reviewed] - TRIC-A channels in vascular smooth muscle contribute to blood pressure maintenance.
Daiju Yamazaki; Yasuharu Tabara; Satomi Kita; Hironori Hanada; Shinji Komazaki; Daisuke Naitou; Aya Mishima; Miyuki Nishi; Hisao Yamamura; Shinichiro Yamamoto; Sho Kakizawa; Hitoshi Miyachi; Shintaro Yamamoto; Toshiyuki Miyata; Yuhei Kawano; Kei Kamide; Toshio Ogihara; Akira Hata; Satoshi Umemura; Masayoshi Soma; Norio Takahashi; Yuji Imaizumi; Tetsuro Miki; Takahiro Iwamoto; Hiroshi Takeshima
Cell metabolism, 03 Aug. 2011, [Reviewed] - [Function of TRPM2 as a Ca(2+)-release channel in β cells].
Yamamoto S; Mori Y
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, May 2011, [Invited]
Lead - Chemical physiology of oxidative stress-activated TRPM2 and TRPC5 channels
Shinichiro Yamamoto; Nobuaki Takahashi; Yasuo Mori
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, Sep. 2010, [Reviewed]
Lead - [TRIC (trimeric intracellular cation)-channel functions during Ca(2+) release from the sarco/endoplasmic reticulum].
Yamazaki D; Yamamoto S; Takeshima H
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, Mar. 2010, [Invited] - Involvement of TRPM2 channel in amplification of reactive oxygen species-induced signaling and chronic inflammation.
Yamamoto S; Shimizu S; Mori Y
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, Sep. 2009, [Invited] - TRPM2 functions as a lysosomal Ca2+-release channel in β cells
Ingo Lange; Shinichiro Yamamoto; Santiago Partida-Sanchez; Yasuo Mori; Andrea Fleig; Reinhold Penner
Science Signaling, 19 May 2009, [Reviewed] - [Ion channels responsible for environmental response: molecular function of TRP channels activated by reactive chemical species].
Yamamoto S; Takahashi N; Kiyonaka S; Mori Y
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Mar. 2009, [Invited]
Lead - Reactive oxygen species-induced signal amplification and chronic inflammation mediated by TRPM2 channels
Yasuo Mori; Shinichiro Yamamoto; Shigeki Kiyonaka; Nobuaki Takahashi; Yuji Kiuchi; Shunichi Shimizu
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009, [Invited] - Structures and variable functions of TRP channels
Tomohiro Numata; Daisuke Kozai; Nobuaki Takahashj; Kenta Kato; Yoshitsugu Uriu; Shinichiro Yamamoto; Takeshi Kaneko; Tatsuo Shinmoto; Yasuo Mori
Seikagaku, 2009, [Reviewed] - TRPM2-mediated Ca(2+) influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration
Shinichiro Yamamoto; Shunichi Shimizu; Shigeki Kiyonaka; Nobuaki Takahashi; Teruaki Wajima; Yuji Hara; Takaharu Negoro; Toshihito Hiroi; Yuji Kiuchi; Takaharu Okada; Shuji Kaneko; Ingo Lange; Andrea Fleig; Reinhold Penner; Miyuki Nishi; Hiroshi Takeshima; Yasuo Mori
NATURE MEDICINE, Jul. 2008, [Reviewed]
Lead - Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators
Nobuaki Takahashi; Yusuke Mizuno; Daisuke Kozai; Shinichiro Yamamoto; Shigeki Kiyonaka; Takahiro Shibata; Koji Uchida; Yasuo Mori
CHANNELS, Jul. 2008, [Reviewed] - Physiological role of the oxidative stress-sensitive activation of TRPM2 Ca2+ channels
Shinichiro Yamamoto; Shigeki Kiyonaka; Nobuaki Takahashi; Yasuo Mori
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2008 - Transient receptor potential channels in Alzheimer's disease.
Yamamoto S; Wajima T; Hara Y; Nishida M; Mori Y
Biochimica et biophysica acta, Aug. 2007, [Reviewed], [Invited]
Lead - Nitric oxide activates TRP channels by cysteine S-nitrosylation
Takashi Yoshida; Ryuji Inoue; Takashi Morii; Nobuaki Takahashi; Shinichiro Yamamoto; Yuji Hara; Makoto Tominaga; Shunichi Shimizu; Yoji Sato; Yasuo Mori
NATURE CHEMICAL BIOLOGY, Nov. 2006, [Reviewed] - Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through the induction of GTP-cyclohydrolase I and increases nitric oxidesynthase activity in vascular endothelial cells
S Shimizu; K Shiota; S Yamamoto; Y Miyasaka; M Ishii; T Watabe; M Nishida; Y Mori; T Yamamoto; Y Kiuchi
FREE RADICAL BIOLOGY AND MEDICINE, May 2003, [Reviewed] - Stimulation of tetrahydrobioptenin synthesis by basic fibroblast growth factor in vascular endothelial cells
S Shimizu; Y Miyasaka; S Yamamoto; M Ishii; Y Kiuchi
PTERIDINES, Mar. 2003, [Reviewed] - Stimulation of tetrahydrobiopterin synthesis by cyclosporin A during lipopolysaccharide treatment in vascular endothelial cells
M Ishii; S Shimizu; K Shiota; S Yamamoto; Y Kiuchi; T Yamamoto
PTERIDINES, Sep. 2002, [Reviewed] - Stimulation of tetrahydrobiopterin synthesis by cyclosporin A in mouse brain microvascular endothelial cells
M Ishii; S Shimizu; K Shiota; S Yamamoto; Y Kiuchi; T Yamamoto
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, Sep. 2002, [Reviewed] - Hydrogen peroxide stimulates the LPS-induced tetrahydrobiopterin synthesis in mouse brain microvascular endothelial cells
K Shiota; S Shimizu; M Ishii; S Yamamoto; M Iwasaki; T Yamamoto; Y Kiuchi
PTERIDINES, Mar. 2002, [Reviewed]
MISC
- 肛門手術における塩酸キニーネ注射薬の検討
白畑 敦; 石田 康男; 大賀 純一; 佐藤 純人; 山本 伸一郎
日本臨床肛門病学会雑誌, Jun. 2021 - ホスホチロシンアダプターShcB欠損マウスにおける小脳機能とプルキンエ細胞内カルシウムシグナル系の阻害
柿澤昌; 柿澤昌; 岸本泰司; 山本伸一郎; 大神和子; 安田邦彦; 堺隆一; 竹島浩; 森望
基礎老化研究, 2013 - Spatio-temporal regulation of intracellular Ca2+ and NO signaling by the TRPC5 channel complex
Nobuaki Takahashi; Takashi Yoshida; Shinichiro Yamamoto; Yoshifumi Ueda; Yasuo Mori
JOURNAL OF PHYSIOLOGICAL SCIENCES, 2013 - TRIC channel function in sarco/endoplasmic reticulum
Daiju Yamazaki; Shinichiro Yamamoto; Miyuki Nishi; Hiroshi Takeshima
JOURNAL OF PHYSIOLOGICAL SCIENCES, 2010 - FACILITATION OF TRPC5 CHANNEL BY CALCIUM
Minoru Wakamori; Takashi Yoshida; Shinichiro Yamamoto; Yasuo Mori
JOURNAL OF PHYSIOLOGICAL SCIENCES, 2009 - 15d-PGJ2, an inflammatory compound, activates TRPA1 channel via cysteine modification
Takahashi Nobuaki; Mizuno Yusuke; Yamamoto Shinichiro; Shibata Takahiro; Mori Yasuo
Proceedings of Annual Meeting of the Physiological Society of Japan, 2008 - Physiological role of the oxidative stress-sensitive TRPM2 Ca2+ channel in immunocytes
Shinichiro Yamamoto; Shunichi Shimizu; Teruaki Wajima; Yasuo Mori
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007 - Nitric oxide activates TRP channels by cysteine S-nitrosylation
Takahashi Nobuaki; Yoshida Takashi; Yamamoto Shinichiro; Mori Yasuo
Proceedings of Annual Meeting of the Physiological Society of Japan, 2007 - Physiological role and activation mechanism of the oxidative stress-susceptible TRPM2 Ca2+ channel in immunocytes
S Yamamoto; S Shimizu; M Ishii; Y Hara; T Hagiwara; T Negoro; M Nishida; T Tobe; Y Kiuchi; Y Mori
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006 - Physiological role and activation mechanism of the oxidative stress-susceptible TRPM2 Ca2+ channel in immunocytes
S Yamamoto; S Shimizu; M Ishii; T Hagiwara; Y Hara; T Negoro; M Nishida; T Tobe; Y Kiuchi; Y Mori
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2005 - 酸化的ストレス感受性Ca〔2+〕チャネルTRPM2の免疫応答細胞における生理的役割 (第26回 生体膜と薬物の相互作用シンポジウム 講演要旨集)
山本 伸一郎; 清水 俊一; 石井 正和
薬学雑誌, 25 Nov. 2004 - U937細胞におけるTRPM2の活性化機構及び生理的役割 (生体機能と創薬シンポジウム2004--イオンチャネル機能と細胞障害--創薬を目指して)
山本 伸一郎; 清水 俊一; 石井 正和
薬学雑誌, 10 Sep. 2004 - U937におけるH2O2刺激によるTRPM2を介したCa2+流入のサイトカイン産生及びアポトーシス誘導に及ぼす影響
山本 伸一郎; 清水 俊一; 根来 孝治; 石井 正和; 原 雄二; 西田 基宏; 戸部 敞; 森 泰生; 木内 祐二
日本薬学会年会要旨集, Mar. 2004 - Possible involvement of hydroxyl radical in H2O2-induced calcium influx through TRPM2 channel
M Ishii; Y Hara; S Yamamoto; Y Mori; S Shimizu; Y Kiuchi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004 - Implication of Ca2+ entry through oxidative stress sensitive TRPM2 channel on IL-8 production by H2O2 in U937 cells
S Yamamoto; S Shimizu; T Negoro; M Ishii; Y Hara; M Nishida; T Tobe; Y Mori; Y Kiuchi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004 - 血管内皮細胞におけるbFGFによるBH4合成の促進
宮坂 善之; 山本 伸一郎; 新本 里香; 石井 正和; 清水 俊一; 木内 祐二
日本薬学会年会要旨集, Mar. 2003
Research Themes
- 糖尿病発症における小胞体ストレス誘導性カルシウムシグナリングの関与の解明
Apr. 2017 - Mar. 2020 - 極性細胞の脂質輸送におけるカルミンの役割の解明
Feb. 2012 - Mar. 2014 - Analysis for physiological role of the Ca2+-binding ER protein calumin
Grant-in-Aid for Young Scientists (B)
Kyoto University
Apr. 2010 - Mar. 2011
