Kenta Yamamoto
| Faculty of Pharmaceutical Sciences,Department of Pharmaceutical Sciences | Associate Professor |
| Graduate School of Pharmaceutical Sciences,Doctoral Program in Pharmaceutical Sciences | Associate Professor |
Last Updated :2025/10/07
■Researcher basic information
■Research activity information
Paper
- Higher central arterial wall viscosity and stiffness in resistance-trained young men.
Hiroshi Kawano; Nobuhiro Nakamura; Kumpei Tanisawa; Masayuki Konishi; Masashi Miyashita; Kenta Yamamoto; Shizuo Sakamoto; Motohiko Miyachi
Physiological reports, Sep. 2025, [Reviewed]
Resistance training reduces arterial compliance. Although cardiac pulsatile energy is distributed between arterial compliance and arterial wall viscosity, arterial wall viscosity in resistance-trained men remains unclear. Therefore, this study aimed to examine whether resistance-trained men exhibit increased arterial wall viscosity. This cross-sectional study included 28 young men (18-25 years), with 12 resistance-trained men and 16 non-trained sedentary controls. We measured arterial wall viscosity, arterial compliance, carotid and brachial blood pressures, peak oxygen uptake, and left ventricular mass and functions. Resistance-trained men had higher arterial wall viscosity (3064 ± 1208 vs. 1993 ± 831 mmHg·s/mm: p = 0.010) and lower compliance (0.093 ± 0.029 vs. 0.153 ± 0.054 mm2/mmHg: p = 0.003) than controls, with an elevated beta-stiffness index (7.90 ± 2.80 vs. 5.86 ± 1.26 AU: p = 0.015). Intima-media thickness and brachial systolic and diastolic blood pressures, peak oxygen uptake, and stroke volume did not differ between groups, although there were significantly higher carotid systolic blood pressure and pulse pressure in resistance-trained men compared to controls. Resistance-trained men showed concentric left ventricular hypertrophy. The present study indicated that central arterial wall viscosity is higher and arterial compliance is lower in resistance-trained men. - Longitudinal trajectory of vascular age indices and cardiovascular risk factors: a repeated-measures analysis
Daiki Watanabe; Yuko Gando; Haruka Murakami; Hiroshi Kawano; Kenta Yamamoto; Akie Morishita; Nobuyuki Miyatake; Motohiko Miyachi
Scientific Reports, 03 Apr. 2023, [Reviewed]
Abstract
This study aimed to identify the modifiable cardiovascular risk factors associated with longitudinal changes, which are nine functional and structural biological vascular aging indicators (BVAIs), to propose an effective method to prevent biological vascular aging. We conducted a longitudinal study of 697 adults (a maximum of 3636 BVAI measurements) who were, at baseline, aged between 26 and 85 years and whose BVAIs were measured at least twice between 2007 and 2018. The nine BVAIs were measured using vascular testing and an ultrasound device. Covariates were assessed using validated questionnaires and devices. During the mean follow-up period of 6.7 years, the average number of BVAI measurements ranged from 4.3 to 5.3. The longitudinal analysis showed a moderate positive correlation between the common carotid intima-media thickness (IMT) and chronological age in both men (r = 0.53) and women (r = 0.54). In the multivariate analysis, BVAIs were associated with factors such as age, sex, residential area, smoking status, blood clinical chemistry test levels, number of comorbidities, physical fitness, body mass, physical activity, and dietary intake. The IMT is the most useful BVAI. Our findings suggest that modifiable cardiovascular risk factors are associated with longitudinal changes in BVAI as represented by IMT. - Effect of a 1-year intervention comprising brief counselling sessions and low-dose physical activity recommendations in Japanese adults, and retention of the effect at 2 years: a randomized trial.
Julien Tripette; Yuko Gando; Haruka Murakami; Ryoko Kawakami; Kumpei Tanisawa; Harumi Ohno; Kana Konishi; Michiya Tanimoto; Noriko Tanaka; Hiroshi Kawano; Kenta Yamamoto; Akie Morishita; Motoyuki Iemitsu; Kiyoshi Sanada; Nobuyuki Miyatake; Motohiko Miyachi
BMC sports science, medicine & rehabilitation, 25 Oct. 2021, [Reviewed]
BACKGROUND: In an effort to increase people's adherence to active lifestyles, contemporary physical activity (PA) guidelines now include low-dose PA. METHODS: PA was evaluated in 583 participants of the Nutritional and Physical Activity Intervention Study (NEXIS) cohort (30-65 years old); 349 inactive participants (MVPA, 2.7 ± 1.0 MET-h/day) were randomly assigned to the intervention or control groups, and 235 active participants participated in follow-up visits. The intervention aimed to increase MVPA and comprised five brief counseling sessions over 1 year. The 1-year target for the participant was increasing their step-count to 10,000 steps/d or +3000 steps/d, relative to the baseline score. The counseling sessions were designed to stimulate progressive changes in physical behaviors by recommendations promoting small and/or light-intensity bouts of PA. PA was measured at baseline, the end of the intervention, and 1 year after the intervention ended. Additionally, several nutrition, health, and fitness parameters were measured. RESULTS: Participants in the intervention group significantly increased their step-count from 8415 ± 1924 at baseline to 9493 ± 2575 at the end of the 1-year period. During the same period, MVPA significantly increased by 0.9 MET-h. The daily time spent in ≥ 3, ≥ 4 and ≥ 5 MET activities increased by 11, 6, and 3 min, respectively. This increase in PA remained observable 1 year after intervention concluded. The active group maintained higher physical activity levels throughout the two years. The intervention group showed smaller energy intakes at the end of the 2-year period. Significant correlations were noted between the 1-year change in MVPA and the change in resting heart rate (r = - 0.22), and between the 2-year change in MVPA and the change in waist circumference (r = - 0.08) and peak oxygen consumption capacity (r = 0.23) in the intervention group only. CONCLUSIONS: A prolonged and progressive PA intervention promoting small bouts of light-to-moderate PA may be used in healthy, not-optimally-active people to increase PA beyond the strict period of the intervention. Further studies are necessary to understand whether low-dose PA messages can be effective in initiating a progressive increase toward larger amounts of PA. TRIAL REGISTRATION: Clinical Trials.gov, NCT00926744, retrospectively registered. - Greater arterial wall viscosity in endurance-trained men.
Hiroshi Kawano; Meiko Asaka; Kenta Yamamoto; Yuko Gando; Masayuki Konishi; Shizuo Sakamoto; Motohiko Miyachi; Mitsuru Higuchi
European journal of applied physiology, Aug. 2021, [Reviewed]
PURPOSE: The age-associated increase in arterial wall viscosity (AWV) is attenuated by high cardiorespiratory fitness level. However, AWV in endurance-trained athletes have not been determined. We designed a cross sectional study to compare central AWV and compliance between endurance-trained young athletes and age-matched control men. METHODS: Twenty-one endurance-trained men (age 20.7 ± 0.3 years) and 20 age-matched healthy control men (age 21.6 ± 0.4 years) were studied. The common carotid artery was measured noninvasively by tonometry and automatic tracking of B-mode images to obtain instantaneous pressure and diameter hysteresis loops, and we calculated the dynamic carotid arterial compliance, static (effective and isobaric) compliance, and viscosity index. RESULTS: The AWV index in the endurance-trained men was larger than the control peers (2285 ± 181 vs. 1429 ± 124 mmHg·s/mm: P < 0.001). In addition, dynamic and static compliance were not statistically different between both groups. CONCLUSION: The present study indicated that the central AWV in endurance-trained athletes was greater than age-matched healthy control men. We believe that the AWV, as well as arterial compliance, is an important element for assessing vascular adaptation to endurance training. - Retraction: PREDICTION MODELS OF SARCOPENIA IN JAPANESE ADULT MEN AND WOMEN
SANADA KIYOSHI; IEMITSU MOTOYUKI; TABATA IZUMI; HIGUCHI MITSURU; OKUMURA SHIGETOSHI; MIYACHI MOTOHIKO; YAMAMOTO KENTA; MURAKAMI HARUKA; TANIMOTO MICHIYA; OMORI YUMI; KAWANO HIROSHI; GANDO YUKO; HANAWA SATOSHI
Japanese Journal of Physical Fitness and Sports Medicine, 2019 - Inhibition of glial glutamate transporter GLT1 in the nucleus of the solitary tract attenuates baroreflex control of sympathetic nerve activity and heart rate.
Yamamoto K; Mifflin S
Physiological reports, Sep. 2018, [Reviewed] - Greater Progression of Age-Related Aortic Stiffening in Adults with Poor Trunk Flexibility: A 5-Year Longitudinal Study
Yuko Gando; Haruka Murakami; Kenta Yamamoto; Ryoko Kawakami; Harumi Ohno; Susumu S. Sawada; Nobuyuki Miyatake; Motohiko Miyachi
FRONTIERS IN PHYSIOLOGY, Jun. 2017, [Reviewed] - Human flexibility and arterial stiffness
KENTA YAMAMOTO
The Journal of Physical Fitness and Sports Medicine, Jan. 2017, [Invited]Most Japanese people have had their flexibility tested in childhood physical education classes. Recent studies may provide a retrospective answer as to why those measurements may be important. Flexibility is one of the components of physical fitness along with cardiorespiratory fitness and muscular strength. Although flexibility was originally assumed to correlate with other aspects of physical fitness, recent studies demonstrate that a less flexible body indicates arterial stiffening. Arterial stiffness has been identified as an independent risk factor for mortality and cardiovascular disorders. Therefore, there is a possibility that flexibility is a novel fitness indicator related to cardiovascular disease, which can be easily evaluated over all ages and in any area (e.g., medical check-up). Now, flexibility may no longer be simply viewed as important just for optimizing functional movement in daily life and/or reducing the risk of injury. This article reviews the recent findings on the relationship between flexibility and arterial stiffness, emphasizing "flexibility and arterial stiffness", "genetics and flexibility", "stretching and arterial stiffness", and "flexibility and blood pressure".
- Poor Trunk Flexibility is Associated With Greater Progression of Age-related Arterial Stiffening: A 5-year Longitudinal Study
Yuko Gando; Kenta Yamamoto; Haruka Murakami; Ryoko Kawakami; Harumi Ohno; Susumu S. Sawada; Nobuyuki Miyatake; Motohiko Miyachi
CIRCULATION, Nov. 2016, [Reviewed] - Cardiorespiratory Fitness Suppresses Age-Related Arterial Stiffening in Healthy Adults: A 2-Year Longitudinal Observational Study
Yuko Gando; Haruka Murakami; Ryoko Kawakami; Kenta Yamamoto; Hiroshi Kawano; Noriko Tanaka; Susumu S. Sawada; Nobuyuki Miyatake; Motohiko Miyachi
JOURNAL OF CLINICAL HYPERTENSION, Apr. 2016, [Reviewed] - Acute intermittent optogenetic stimulation of nucleus tractus solitarius neurons induces sympathetic long-term facilitation
Kenta Yamamoto; Peter Lalley; Steve Mifflin
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, Feb. 2015, [Reviewed] - Evaluation of active video games intensity: Comparison between accelerometer-based predictions and indirect calorimetric measurements
Julien Tripette; Takafumi Ando; Haruka Murakami; Kenta Yamamoto; Kazunori Ohkawara; Shigeho Tanaka; Motohiko Miyachi
TECHNOLOGY AND HEALTH CARE, 2014, [Reviewed] - Lack of age-related increase in carotid artery wall viscosity in cardiorespiratory fit men
Hiroshi Kawano; Kenta Yamamoto; Yuko Gando; Michiya Tanimoto; Haruka Murakami; Yumi Ohmori; Kiyoshi Sanada; Izumi Tabata; Mitsuru Higuchi; Motohiko Miyachi
JOURNAL OF HYPERTENSION, Dec. 2013, [Reviewed] - Knockdown of tyrosine hydroxylase in the nucleus of the solitary tract reduces elevated blood pressure during chronic intermittent hypoxia
Chandra Sekhar Bathina; Anuradha Rajulapati; Michelle Franzke; Kenta Yamamoto; J. Thomas Cunningham; Steve Mifflin
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, Nov. 2013, [Reviewed] - Resetting of the sympathetic baroreflex is associated with the onset of hypertension during chronic intermittent hypoxia
Kenta Yamamoto; Wendy Eubank; Michelle Franzke; Steve Mifflin
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, Jan. 2013, [Reviewed] - [A cross-sectional study of sarcopenia in Japanese men and women: reference values and association with cardiovascular risk factors and metabolic syndrome].
Kiyoshi Sanada; Motoyuki Iemitsu; Izumi Tabata; Motohiko Miyachi; Haruka Murakami; Kenta Yamamoto; Satoshi Hanawa; Ryouko Kawakami; Hiroshi Kawano; Yuko Gando; Katsuhiko Suzuki; Mitsuru Higuchi; Michiya Tanimoto; Yumi Omori
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 2012, [Reviewed] - PPAR gamma 2 C1431T genotype increases metabolic syndrome risk in young men with low cardiorespiratory fitness
Kiyoshi Sanada; Motoyuki Iemitsu; Haruka Murakami; Izumi Tabata; Kenta Yamamoto; Yuko Gando; Katsuhiko Suzuki; Mitsuru Higuchi; Motohiko Miyachi
PHYSIOLOGICAL GENOMICS, Feb. 2011, [Reviewed] - Attenuated Age-Related Carotid Arterial Remodeling in Adults with a High Level of Cardiorespiratory Fitness
Yuko Gando; Kenta Yamamoto; Hiroshi Kawano; Haruka Murakami; Yumi Ohmori; Ryoko Kawakami; Kiyoshi Sanada; Mitsuru Higuchi; Izumi Tabata; Motohiko Miyachi
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 2011, [Reviewed] - Greater forearm venous compliance in resistance-trained men
Hiroshi Kawano; Michiya Tanimoto; Kenta Yamamoto; Yuko Gando; Kiyoshi Sanada; Izumi Tabata; Mitsuru Higuchi; Motohiko Miyachi
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, Nov. 2010, [Reviewed] - Longer Time Spent in Light Physical Activity Is Associated With Reduced Arterial Stiffness in Older Adults
Yuko Gando; Kenta Yamamoto; Haruka Murakami; Yumi Ohmori; Ryoko Kawakami; Kiyoshi Sanada; Mitsuru Higuchi; Izumi Tabata; Motohiko Miyachi
HYPERTENSION, Sep. 2010, [Reviewed] - Lack of carotid stiffening associated with MTHFR 677TT genotype in cardiorespiratory fit adults
Motoyuki Iemitsu; Haruka Murakami; Kiyoshi Sanada; Kenta Yamamoto; Hiroshi Kawano; Yuko Gando; Motohiko Miyachi
PHYSIOLOGICAL GENOMICS, Jul. 2010, [Reviewed] - METs in Adults While Playing Active Video Games: A Metabolic Chamber Study
Motohiko Miyachi; Kenta Yamamoto; Kazunori Ohkawara; Shigeho Tanaka
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, Jun. 2010, [Reviewed] - Age and cardiorespiratory fitness are associated with arterial stiffening and left ventricular remodelling
Gando Y; Kawano H; Yamamoto K; Sanada K; Tanimoto M; Oh T; Ohmori Y; Miyatani M; Usui C; Takahashi E; Tabata I; Higuchi M; Miyachi M
J Hum Hypertens, 2010, [Reviewed] - A cross-sectional study of sarcopenia in Japanese men and women: reference values and association with cardiovascular risk factors
Sanada K; Miyachi M; Tanimoto M; Yamamoto K; Murakami H; Okumura S; Gando Y; Suzuki K; Tabata I; Higuchi M
Eur J Appl Physiol, 2010, [Reviewed] - Poor trunk flexibility is associated with arterial stiffening
Kenta Yamamoto; Hiroshi Kawano; Yuko Gando; Motoyuki Iemitsu; Haruka Murakami; Kiyoshi Sanada; Michiya Tanimoto; Yumi Ohmori; Mitsuru Higuchi; Izumi Tabata; Motohiko Miyachi
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Oct. 2009, [Reviewed] - 保健指導としての運動指導 ―NPO法人「早稲田の杜」の設立と今後―
真田樹義; 宮地元彦; 丸山浩平; 山元健太; 鈴木克彦; 樋口 満; 朝日 透; 坂本静男; 大坪真也; 山内 繁; 塙 智史; 片山利恵; 梅里泰正
スポーツ科学研究, May 2009 - Low-intensity resistance training with slow movement and tonic force generation increases basal limb blood flow
Michiya Tanimoto; Hiroshi Kawano; Yuko Gando; Kiyoshi Sanada; Kenta Yamamoto; Naokata Ishii; Izumi Tabata; Motohiko Miyachi
CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING, Apr. 2009, [Reviewed] - Differences in body composition and risk of lifestyle-related diseases between young and older male rowers and sedentary controls
Kiyoshi Sanada; Motohiko Miyachi; Izumi Tabata; Katsuhiko Suzuki; Kenta Yamamoto; Hiroshi Kawano; Chiyoko Usui; Mitsuru Higuchi
JOURNAL OF SPORTS SCIENCES, 2009, [Reviewed] - Muscle mass and bone mineral indices: does the normalized bone mineral content differ with age?
Sanada K; Miyachi M; Tabata I; Miyatani M; Tanimoto M; Oh TW; Yamamoto K; Usui C; Takahashi E; Kawano H; Gando Y; Higuchi M
Eur J Clin Nutr, 2009, [Reviewed] - EFFECTS OF WHOLE-BODY LOW-INTENSITY RESISTANCE TRAINING WITH SLOW MOVEMENT AND TONIC FORCE GENERATION ON MUSCULAR SIZE AND STRENGTH IN YOUNG MEN
Michiya Tanimoto; Kiyoshi Sanada; Kenta Yamamoto; Hiroshi Kawano; Yuko Gando; Izumi Tabata; Naokata Ishii; Motohiko Miyachi
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH, Nov. 2008, [Reviewed] - Muscle mechanoreflex augments arterial baroreflex-mediated dynamic sympathetic response to carotid sinus pressure
Kenta Yamamoto; Toru Kawada; Atsunori Kamiya; Hiroshi Takaki; Toshiaki Shishido; Kenji Sunagawa; Masaru Sugimachi
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Sep. 2008, [Reviewed] - Required muscle mass for preventing lifestyle-related diseases in Japanese women
Masae Miyatani; Hiroshi Kawano; Kei Masani; Yuko Gando; Kenta Yamamoto; Michiya Tanimoto; Taewoong Oh; Chiyoko Usui; Kiyoshi Sanada; Mitsuru Higuchi; Izumi Tabata; Motohiko Miyachi
BMC PUBLIC HEALTH, Aug. 2008, [Reviewed] - Upright tilt resets dynamic transfer function of baroreflex neural arc to minify the pressure disturbance in total baroreflex control
Atsunori Kamiya; Toru Kawada; Kenta Yamamoto; Masaki Mizuno; Shuji Shimizu; Masaru Sugimachi
JOURNAL OF PHYSIOLOGICAL SCIENCES, Jun. 2008, [Reviewed] - Resistance training in men is associated with increased arterial stiffness and blood pressure but does not adversely affect endothelial function as measured by arterial reactivity to the cold pressor test
Hiroshi Kawano; Michiya Tanimoto; Kenta Yamamoto; Kiyoshi Sanada; Yuko Gando; Izumi Tabata; Mitsuru Higuchi; Motohiko Miyachi
EXPERIMENTAL PHYSIOLOGY, Feb. 2008, [Reviewed] - The Use of a Uniaxial Accelerometer to Assess Physical-activity Energy Expenditure in Obese Men and Women: Saku Control Obesity Program (SCOP)
Miyachi M; Ohmori Y; Yamamoto K; Kawano K; Murakami H; Morita A; Watanabe S
Anti-Aging Medicine, 2008, [Reviewed]
身体活動に伴うエネルギー消費は、肥満やその関連疾患と負の関係があり、運動はこれらの疾患の予防改善に重要な役割を果たす。本研究は、230名の肥満者を対象に日常の歩数と身体活動関連エネルギー消費量を測定し、身体活動量と腹部脂肪との関係を検討した。結果として、加速度計で評価した身体活動量は全身性肥満だけでなく、腹部肥満とも部分的に関係した。 - Nonexercise models for predicting maximal oxygen uptake existing physiological basis [2]
Kiyoshi Sanada; Taishi Midorikawa; Tomohiro Yasuda; Motohiko Miyachi; Kenta Yamamoto; Charles F. Kearns; Takashi Abe
European Journal of Applied Physiology, 01 Sep. 2007 - Short-term electroacupuncture at Zusanli resets the arterial baroreflex neural arc toward lower sympathetic nerve activity
D Michikami; A Kamiya; T Kawada; M Inagaki; T Shishido; K Yamamoto; H Ariumi; S Iwase; J Sugenoya; K Sunagawa; M Sugimachi
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Jul. 2006, [Reviewed] - Dynamic and static baroreflex control of muscle sympathetic nerve activity (SNA) parallels that of renal and cardiac SNA during physiological change in pressure
A Kamiya; T Kawada; K Yamamoto; D Michikami; H Ariumi; T Miyamoto; S Shimizu; K Uemura; T Aiba; K Sunagawa; M Sugimachi
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Dec. 2005, [Reviewed] - Static interaction between muscle mechanoreflex and arterial baroreflex in determining efferent sympathetic nerve activity
K Yamamoto; T Kawada; A Kamiya; H Takaki; M Sugimachi; K Sunagawa
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Oct. 2005, [Reviewed] - Low-frequency oscillation of sympathetic nerve activity decreases during development of tilt-induced syncope preceding sympathetic withdrawal and bradycardia
A Kamiya; J Hayano; T Kawada; D Michikami; K Yamamoto; H Ariumi; S Shimizu; K Uemura; T Miyamoto; T Aiba; K Sunagawa; M Sugimachi
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Oct. 2005, [Reviewed] - Resetting of the arterial baroreflex increases orthostatic sympathetic activation and prevents postural hypotension in rabbits
A Kamiya; T Kawada; K Yamamoto; D Michikami; H Ariumi; K Uemura; C Zheng; S Shimizu; T Aiba; T Miyamoto; M Sugimachi; K Sunagawa
JOURNAL OF PHYSIOLOGY-LONDON, Jul. 2005, [Reviewed] - Muscle sympathetic nerve activity averaged over 1 minute parallels renal and cardiac sympathetic nerve activity in response to a forced baroreceptor pressure change
A Kamiya; T Kawada; K Yamamoto; D Michikami; H Ariumi; T Miyamoto; K Uemura; M Sugimachi; K Sunagawa
CIRCULATION, Jul. 2005, [Reviewed] - Dynamic characteristics of carotid sinus pressure-nerve activity transduction in rabbits
T Kawada; K Yamamoto; A Kamiya; H Ariumi; D Michikami; T Shishido; K Sunagawa; M Sugimachi
JAPANESE JOURNAL OF PHYSIOLOGY, Jun. 2005, [Reviewed] - Muscle mechanoreflex induces the pressor response by resetting the arterial baroreflex neural arc
K Yamamoto; T Kawada; A Kamiya; H Takaki; T Miyamoto; M Sugimachi; K Sunagawa
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Apr. 2004, [Reviewed] - 交感神経活動調節における動脈圧反射と筋機械受容器反射との相互作用は閾値付き加算モデルで説明できる
Apr. 2004 - Non-invasive assessment of cardiac output during exercise in healthy young humans: comparison between Modelflow method and Doppler echocardiography method
J Sugawara; T Tanabe; M Miyachi; K Yamamoto; K Takahashi; M Iemitsu; T Otsuki; S Homma; S Maeda; R Ajisaka; M Matsuda
ACTA PHYSIOLOGICA SCANDINAVICA, Dec. 2003 - 筋機械受容器反射は動脈圧反射の中枢弓を変化させ昇圧反応を引き起こす
May 2003 - Greater age-related reductions in central arterial compliance in resistance-trained men
M Miyachi; AJ Donato; K Yamamoto; K Takahashi; PE Gates; KL Moreau; H Tanaka
HYPERTENSION, Jan. 2003, [Reviewed] - Structural vascular-ventricular coupling in endurance training: Influence on maximal oxygen uptake
M. Miyachi; K. Takahashi; K. Yamamoto; A. Yoshioka; S. Matsueda; S. Onodera
Japanese Journal of Physical Fitness and Sports Medicine, 01 Feb. 2002 - The relationship between cardiovascular structure and aerobic capacity
Kouki Takahashi; Takeiiiko Takamoto; Kouhei Fujimoto; Ken Yamasaki; Ken-Ta Yamamoto; Motoiiiko Miyachi; Osamu Ylitzuki
Japanese Journal of Physical Fitness and Sports Medicine, 2002, [Reviewed] - 光電管を用いたラット回転ケージ運動の評価法
2002, [Reviewed] - Effects of one-legged endurance training on femoral arterial and venous size in healthy humans
Motohiko Miyachi; Hirofumi Tanaka; Kenta Yamamoto; Akira Yoshioka; Kouki Takahashi; Sho Onodera
Journal of Applied Physiology, 01 Jun. 2001 - Effects of water depth on abdominal [correction of abdominails] aorta and inferior vena cava during standing in water.
S. Onodera; M. Miyachi; M. Nishimura; K. Yamamoto; H. Yamaguchi; K. Takahashi; J. Y. In; H. Amaoka; A. Yoshioka; T. Matsui; H. Hara
Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology, 01 Jan. 2001 - Effects of endurance training on resting and post-exercise cardiac autonomic control
K. Yamamoto; M. Miyachi; T. Saitoh; A. Yoshioka; S. Onodera
Medicine and Science in Sports and Exercise, 01 Jan. 2001 - A practical studies of autistic children during water exercises
Sho Onodera; Youko Hoshijima; Motohiko Miyachi; Hidetaka Yamaguchi; Masahiro Nishimura; Kenta Yamamoto; Hiroshi Amaoka; Joo Yonin
Japanese Journal of Physical Fitness and Sports Medicine, 01 Jan. 2000
MISC
- Arterial Wall Viscosity Is Associated With Cardiorespiratory Fitness Independently Of Aging
Hiroshi Kawano; Kenta Yamamoto; Yuko Gando; Michiya Tanimoto; Haruka Murakami; Yumi Ohmori; Kiyoshi Sanada; Izumi Tabata; Mitsuru Higuchi; Motohiko Miyachi
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, May 2014 - Acute intermittent optogenetic stimulation of glutamatergic NTS neurons induces sympathetic long-term facilitation
Kenta Yamamoto; Chandra Sekhar Bathina; Anuradha Rajulapati; Michelle Franzke; Steve Mifflin
FASEB JOURNAL, Apr. 2013 - Acute Effects of Stretching Exercise on Arterial Stiffness
Yuko Gando; Kenta Yamamoto; Hiroshi Kawano; Isao Muraoka
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, May 2012 - The effects of 7 day exposure to intermittent hypoxia on renal and cervical sympathetic nerve responses to acute hypoxia in rats
Wendy Eubank; Kenta Yamamoto; Michelle Franzke; Steve Mifflin
FASEB JOURNAL, Apr. 2012 - Astrocytes in NTS after exposure to chronic intermittent hypoxia
Kenta Yamamoto; Chengbo Yuan; Wendy Eubank; Michelle Franzke; Steve Mifflin
FASEB JOURNAL, Apr. 2012 - A cross-sectional study of sarcopenia in Japanese men and women: reference values and association with cardiovascular risk factors and metabolic syndrome
真田樹義; 家光素行; 田畑泉; 宮地元彦; 村上晴香; 山元健太; 塙智史; 川上諒子; 河野寛; 丸藤祐子; 鈴木克彦; 樋口満; 谷本道哉; 大森由実
日本老年医学会雑誌, 2012
The Japan Geriatrics Society - Attenuated Age-related Carotid Arterial Remodeling In Adults With High Level Of Cardiorespiratory Fitness
Yuko Gando; Kenta Yamamoto; Hiroshi Kawano; Haruka Murakami; Yumi Ohmori; Ryoko Kawakami; Kiyoshi Sanada; Mitsuru Higuchi; Izumi Tabata; Motohiko Miyachi
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, May 2011 - Exposure to chronic intermittent hypoxia is not associated with the sympathetic baroreflex dysfunction
Kenta Yamamoto; Wendy Eubank; Steve Mifflin
FASEB JOURNAL, Apr. 2011 - PREDICTION MODELS OF SARCOPENIA IN JAPANESE ADULT MEN AND WOMEN
Kiyoshi Sanada; Motohiko Miyachi; Kenta Yamamoto; Haruka Murakami; Mchiya Tanimoto; Yumi Omori; Hiroshi Kawano; Yuko Gando; Satoshi Hanawa; Motoyuki Iemitsu; Izumi Tabata; Mitsuru Higuchi; Shigetoshi Okumura
JAPANESE JOURNAL OF PHYSICAL FITNESS AND SPORTS MEDICINE, Jun. 2010 - Comparison Of Cardiovascular Risks And Physical Fitness Between Sarcopenia obesity And Metabolic Syndrome in Elderly people
Kiyoshi Sanada; Motohiko Miyachi; Motoyuki Iemitsu; Haruka Murakami; Kenta Yamamoto; Yuko Gando; Michiya Tanimoto; Mitsuru Higuchi; Izumi Tabata
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, May 2010 - 健康づくりのための運動基準・エクササイズガイド改定に関する研究 柔軟性体力と動脈硬化に関する研究
田畑泉; 宮地元彦; 山元健太
健康づくりのための運動基準・エクササイズガイド改定に関する研究 平成21年度 総括研究報告書, 2010 - 体力レベルの違いが動脈stiffnessとMTHFR遺伝子多型の関係に及ぼす影響
家光素行; 村上晴香; 真田樹義; 山元健太; 河野寛; 丸藤祐子; 谷本道哉; 田畑泉; 宮地元彦
体力科学, 01 Dec. 2009 - 血中ホモシステイン濃度と脚伸展パワーとMTHFR遺伝子多型との関連
村上晴香; 家光素行; 真田樹義; 谷本道哉; 田中憲子; 塙智史; 山元健太; 丸藤祐子; 川上諒子; 宮地元彦
体力科学, 01 Dec. 2009 - 3次元加速度計を用いた身体活動量および心肺体力と動脈硬化との関係
丸藤祐子; 山元健太; 村上晴香; 川上諒子; 谷本道哉; 塙智史; 田中憲子; 田畑泉; 樋口満; 宮地元彦
体力科学, 01 Dec. 2009 - Energy Expenditure in Adults When Playing Next-generation Video Games: A Metabolic Chamber Study
Motohiko Miyachi; Kenta Yamamoto; Kazunori Ohkawara; Shigeho Tanaka
CIRCULATION, Nov. 2009 - 生活習慣病一次予防に必要な身体活動量・体力基準値策定を目的とした大規模介入研究 身体活動量と動脈の硬化度(頸動脈IMT)との関連
宮地元彦; 田畑泉; 丸藤祐子; 山元健太
生活習慣病一次予防に必要な身体活動量・体力基準値策定を目的とした大規模介入研究 平成20年度 総括・分担研究報告書, 2009 - 生活習慣病一次予防に必要な身体活動量・体力基準値策定を目的とした大規模介入研究における血圧および動脈の硬化度の変化
宮地元彦; 田畑泉; 丸藤祐子; 山元健太
生活習慣病一次予防に必要な身体活動量・体力基準値策定を目的とした大規模介入研究 平成20年度 総括・分担研究報告書, 2009 - 血中ホモシステイン濃度とMTHFR遺伝子多型の関連に対する身体活動および葉酸摂取の影響
村上晴香; 家光素行; 山元健太; 河野寛; 丸藤祐子; 真田樹義; 宮地元彦
体力科学, 01 Dec. 2008 - 生活習慣病一次予防に必要な身体活動量・体力基準値策定を目的とした大規模介入研究 加速度計を用いた身体活動介入が歩数と身体活動量に及ぼす効果
宮地元彦; 大森由実; 村上晴香; 山元健太; 河野寛; 森田明美; 渡邊昌
生活習慣病一次予防に必要な身体活動量・体力基準値策定を目的とした大規模介入研究 平成19年度 総括・分担研究報告書, 2008 - 生活習慣病一次予防に必要な身体活動量・体力基準値策定を目的とした大規模介入研究 体力の一要素である柔軟性と動脈硬化の関係
宮地元彦; 田畑泉; 山元健太
生活習慣病一次予防に必要な身体活動量・体力基準値策定を目的とした大規模介入研究 平成19年度 総括・分担研究報告書, 2008 - 中高年男女を対象とした肥満関連遺伝子,身体組成,有酸素性能力とメタボリックシンドロームとの関係
真田樹義; 宮地元彦; 山元健太; 村上晴香; 家光素行; 谷本道哉; 河野寛; 丸藤祐子; 鈴木克彦; 田畑泉; 樋口満
体力科学, 01 Dec. 2007 - 心肺体力の高い女性では加齢による動脈硬化と左心室肥大が抑制される
丸藤祐子; 宮地元彦; 河野寛; 真田樹義; 山元健太; 谷本道哉; 呉泰雄; 宮谷昌枝; 薄井澄誉子; 高橋恵理; 田畑泉; 樋口満
体力科学, 01 Dec. 2007 - How Does the Central Adaptive Mechanism Contribute to the Attenuation of Exercise Hyperpnea from Strenuous Regular Exercise Training?
宮本忠吉; 山元健太; 神谷厚範; 高木洋; 杉町勝
デサントスポーツ科学, 07 Jun. 2007 - Modeling of the static interaction between muscle mechanoreflex and arterial baroreflex in determining sympathetic nerve activity
山元健太; 道上大策; 宍戸稔聡; 川田徹; 神谷厚範; 高木洋; 砂川賢二; 杉町勝
生体・生理工学シンポジウム論文集, 05 Sep. 2005 - Effects of electroacupuncture on static and dynamic characteristics of arterial baroreflex
道上大策; 川田徹; 神谷厚範; 宍戸稔聡; 山元健太; 有海秀人; 砂川賢二; 杉町勝
生体・生理工学シンポジウム論文集, 05 Sep. 2005 - The relationship between the effects of elastic components of muscle and tendon in human triceps surae and decrease of oxygen uptake during rope skipping
Yamaguchi Hidetaka; Yamamoto Kenta; Edamatsu Cihiro; Takahashi kouki; Miyakawa Takeshi; Nishimura Kazuki; Onodera Sho
Journal of Kibi International University School of Social Welfare, 31 Mar. 2005
Kibi International University - Regular exercise training attenuates exercise hyperpnea through adaptation of both controller and plant of respiratory chemoreflex system
宮本忠吉; 稲垣正司; 高木洋; 川田徹; 山元健太; 杉町勝; 砂川賢二
生体・生理工学シンポジウム論文集, 01 Nov. 2004 - The muscle mechanoreflex increases dynamic gain of the arterial baroreflex neural arc
山元健太; 川田徹; 神谷厚範; 高木洋; 宮本忠吉; 杉町勝; 砂川賢二
生体・生理工学シンポジウム論文集, 01 Nov. 2004 - Muscle sympathetic nerve activity parallels cardiac and renal sympathetic nerve activity
A Kamiya; T Kawada; K Yamamoto; M Sugimachi; K Sunagawa
FASEB JOURNAL, Mar. 2004 - Simple summation with threshold explains the interaction between the arterial baroreflex and muscle mechanoreflex in determining sympathetic nerve activity
T Kawada; K Yamamoto; K Uemura; A Kamiya; K Sunagawa
FASEB JOURNAL, Mar. 2004 - 最大酸素摂取量と左心室および大動脈形態との関係
高橋康輝; 宮地元彦; 藤本広平; 高本健彦; 山崎健; 松枝秀二; 山元健太; 柚木脩
体育学研究, 10 Nov. 2003
Endurance-trained athletes with higher aerobic power (Vo_2max) have a large-sized left ventricle (LV) and aorta (Ao). We therefore hypothesized that the individual variability of Vo_2ax can be estimated using resting LV and Ao dimensions. In looking at this question we performed a laboratory-based cross-sectional study to determine the relationship between Vo_2max, LV dimensions, and Ao dimensions in young subjects with wide ranges of physical activity status. One hundred forty-two healthy young men (20-35 years), who were either sedentary, recreationally active or endurance-trained, participated in the cross-sectional study. Subsequently, a meta-analysis approach was used to collect 28 studies involving 58 groups and 816 subjects. LV and Ao dimensions were determined by echocardiography at supine rest. In the cross-sectional study and meta-analysis, LV end-diastolic diameter (LVEDD) and end-systolic diameter (LVESD), posterior wall thickness (PWT) and inter-ventricular septum thickness (IVST), and Ao diameter (AoD) were positively and significantly correlated with Vo,max. When we performed a stepwise regression analysis in the cross-sectional study to determine independent predictors of Vo_2max, the variables entered were LVEDD, AoD, and PWT, which together explained 60-70% of the variability. Furthermore, we attempted to develop equations for predicting Vo_2max. Multiple regression analyses using LVEDD, AoD, and PWT as the explanatory variables for predicting Vo2max yielded the following equations. Vo_2max (ml・min^<-1>・kg^<-1>) = 49.2 LVEDD (mm/kg) + 27.2 AoD (mm/kg) + 43.9 IVST (mm/kg) -2.6. These results suggest that the variability of Vo_2max can be accounted for by differences in both left ventricular and aortic structure. Furthermore, echocardiography at supine-rest was useful for evaluating maximal aerobic power, specifically for young healthy men, who demonstrated a wide range of trained states., Japan Society of Physical Education, Health and Sport Sciences - The muscle mechanoreflex increases the gain of arterial baroreflex neural arc
山元健太; 川田徹; 神谷厚範; 高木洋; 宮本忠吉; 杉町勝; 砂川賢二
生体・生理工学シンポジウム論文集, 06 Oct. 2003 - 有酸素性作業能力と左心室および大動脈形態との関係 メタ解析による分析
高橋康輝; 高本健彦; 藤本広平; 山崎健; 山元健太; 宮地元彦; 柚木おさむ
体力科学, 01 Oct. 2002
The Japanese Society of Physical Fitness and Sport Medicine - Effects of water immersion on systemic cardiovascular responses during recovery period following steady state land exercise
T Matsui; M Miyachi; Y Hoshijima; K Takahashi; K Yamamoto; A Yoshioka; S Onodera
JAPANESE JOURNAL OF PHYSICAL FITNESS AND SPORTS MEDICINE, Jun. 2002 - Effect of different frequencies of skipping rope on elastic components of muscle and tendon in human triceps surae
H Yamaguchi; K Yamamoto; C Edamatsu; G Hayata; T Miyakawa; S Onodera
JAPANESE JOURNAL OF PHYSICAL FITNESS AND SPORTS MEDICINE, Apr. 2002 - 自閉症児のための水を活用したリハビリテーションプログラム 実践プログラム
小野寺昇; 星島葉子; 宮地元彦; 河野由美子; 杉哉子; 山口英峰; 山元健太; 石本恭子; 西村正広
体力科学, 01 Dec. 2001 - 自閉症児のための水を活用したリハビリテーションプログラム 問題行動への効果
杉哉子; 小野寺昇; 星島葉子; 宮地元彦; 西村正広; 山口英峰; 山元健太; 天岡寛; 石本恭子
体力科学, 01 Dec. 2001 - 自閉症児のための水を活用したリハビリテーションプログラム 身体活動への効果
星島葉子; 小野寺昇; 宮地元彦; 山口英峰; 西村正広; 山元健太; 天岡寛; 杉哉子; 石本恭子
体力科学, 01 Dec. 2001 - 自閉症児のための水中運動を活用したリハビリテーションプログラムの実践
小野寺昇; 星島葉子; 宮地元彦; 西村正広; 山口英峰; 高橋康輝; 山元健太; 天岡寛; 石本恭子
体力科学, 01 Oct. 2001
The Japanese Society of Physical Fitness and Sport Medicine - The relationship between resting bradycardia with endurance training and autonomic nervous system modulation
K Yamamoto; K Takahashi; A Yoshioka; S Onodera; M Miyachi
JAPANESE JOURNAL OF PHYSICAL FITNESS AND SPORTS MEDICINE, Oct. 2001 - 光電管を用いたラットの回転ケージ運動量の定量と速度算出の妥当性
松崎裕美; 天岡寛; 山元健太; 枝松千尋; 矢野博己
体力科学, 01 Aug. 2001
The Japanese Society of Physical Fitness and Sport Medicine - 一過性および慢性の片脚運動に対する心臓自律神経系活動の反応
吉岡哲; 宮地元彦; 山元健太; 高橋康輝; 小野寺昇
体力科学, 01 Aug. 2001
The Japanese Society of Physical Fitness and Sport Medicine - 8.Changes of muscle relaxation manner during triceps surae uscles.
YAMAGUCHI HIDETAK; EDAMATSU CHIHIRO; TAKAHASHI KOUKI; YAMAMOTO KENTA; MIYAKAWA TAKESHI; ONODERA SHO
Japanese Journal of Physical Fitness and Sports Medicine, 01 Aug. 2001
The Japanese Society of Physical Fitness and Sport Medicine - なわとびにおける跳躍周期の違いが床反力に及ぼす影響
山口英峰; 山元健太; 宮川健; 宮地元彦; 小野寺昇
川崎医療福祉学会誌, 25 Dec. 2000
The purpose of this study was to analyze the effects of differences in jump frequency during rope skipping on ground reaction force (GRF). Six male subjects volunteered to participate in this experiment. They jumped to different frequencies of 72,80,92,100,112,120,132 skips per minute (SPM) in synchronization with a metronome. Ground reaction force, contact time and flight time were analyzed with a force plate. Maximal peak value of the vertical GRF from 92 to 100 SPM was the lowest of all jump frequencies. The result suggest burden to the knee is the smallest for rope skipping at 90〜100 SPM., Kawasaki University of Medical Welfare - 049G20103 自閉症児のための水中運動プログラムの開発
25 Aug. 2000 - Changes in heart rate, rating of perceived exertion and rectal temperature during climbing Mt. Daisen in summer.
小野寺昇; 山口英峰; 斉藤剛; 山元健太; 鳥越康江; 青山賢吾; 安保真一; 高橋康輝; 松井健
登山医学, 10 Dec. 1999 - 大山夏山登山における心拍数,RPE及び直腸温変化
小野寺昇; 安保真一; 青山賢吾; 山元健太; 星島葉子; 鳥越康江; 高橋康輝; 山口英峰; 斎藤剛
日本登山医学シンポジウムプログラム・抄録集, 21 May 1999 - 塩水を用いた水中リラクゼーション時の心拍数と酸素摂取量
Feb. 1999 - Effects of Backpack Weight on Rating Perceived Exertion and Heart Rate while Climbing Mt. Daisen in Summer. (The first report). A comparison of backpack between 10% and 40% body weight.
安保真一; 青山賢吾; 星島葉子; 鳥越康江; 山元健太; 山口英峰; 斉藤剛; 小野寺昇; 松井健
登山医学, Dec. 1998 - Effects of Backpack Weight on Rating Perceived Exertion and Heart Rate while Climbing Mt. Daisen in Summer. (The second report). A simulation with treadmill exercise.
安保真一; 青山賢吾; 星島葉子; 鳥越康江; 山元健太; 山口英峰; 斉藤剛; 小野寺昇; 松井健
登山医学, Dec. 1998 - 264.持久的トレーニングが運動後回復時の自律神経活動に及ぼす影響:心拍変動スペクトル解析を用いて
01 Dec. 1998 - 60.陸上及び水中運動における1単位80kcalの運動強度と運動時間
01 Dec. 1998 - 61.水中運動における曲の拍子が心拍数と酸素摂取量に及ぼす影響
01 Dec. 1998 - 71.中高年者の水中運動における動作が心拍数と酸素摂取量におよぼす影響
01 Dec. 1998 - Effects of Relaxation in the Water on Heart Rate, Blood Pressure and oxygen Uptake in the Elderly.
西村正広; 山元健太; 星島葉子; 鳥越康恵; 安保真一; 宮地元彦; 小野寺昇
疲労と休養の科学, Aug. 1998 - Effect of Backpack Weight on Rating Perceived Exertion and Heart rate During Treadmill Walking.
安保真一; 山元健太; 小野寺昇
登山医学, Dec. 1997 - 248.新型水中エルゴメーターを用いた運動負荷時の心拍数と酸素摂取量の変化
01 Dec. 1997 - Changes of Heart Rate and Oxygen Uptake During Use of a New Type Ergometer in Water.
小野寺昇; 山元健太; 西村正広; 宮地元彦
川崎医療福祉学会誌, Jun. 1997
Kawasaki University of Medical Welfare
Research Themes
- Combined effects of exercise and SGLT2 inhibitor treatment on prevention of heart failure
Grant-in-Aid for Scientific Research (C)
Teikyo Heisei University
01 Apr. 2023 - 31 Mar. 2026 - Interactive effects of habitual exercise and SGLT2 inhibitor treatment on glycemic control in patients with diabetes mellitus
Grant-in-Aid for Scientific Research (C)
Teikyo Heisei University
Apr. 2020 - Mar. 2023
In this study, we investigated the combined effects of daily physical activity and SGLT2 inhibitor treatment on glycemic control in patients with uncontrolled glycemia (HbA1c ≧ 7.0%) with type 2 diabetes using a large health insurance claims and health checkup database in Japan. The glycemic control rates were higher in patients who combined SGLT2 inhibitors with physical activity (43.3 and 19.9% in HbA1c < 7.0 and < 6.5%, respectively) than in those without physical activity (32.3 and 12.1%). The present study suggests that even modest increases in daily life activity levels, such as walking, can contribute to better control of blood glucose levels in patients with type 2 diabetes taking SGLT2 inhibitors. - Relationships between flexibility, arterial stiffening and the sympathetic nervous system
Grant-in-Aid for Young Scientists (B)
National Institute of Health and Nutrition
Apr. 2009 - Mar. 2011
The present study tested the following hypothesis : (1) a stretching intervention for 6 months will attenuate arterial stiffening ; and (2) the sympathetic nervous system mediates the relationship between flexibility and arterial stiffness. The results suggest that (1) improving flexibility induced by stretching exercise attenuates arterial stiffening with aging ; and (2) that this relationship between flexibility and arterial stiffening might not be mediated by the sympathetic nervous system. Although the present study failed to clarify the mechanisms for the relationship between flexibility and arterial stiffness, this study indicates a possibility that flexibility exercise should be integrated as a new recommendation into the known cardiovascular benefit of regular exercise. - Adaptations of central arterial viscoelasticity with aerobic training
Grant-in-Aid for Young Scientists (B)
Waseda University
2009 - 2010
The aim of this study was to determine 1) relationship between cardiorespiratory fitness and central arterial viscoelasticity, and 2) effect of aerobic training on central arterial viscoelasticity. In first study, age-associated increase in central arterial viscosity was suppressed by maintenance of cardiorespiratory fitness. However, in second study, when performing 10-week aerobic training, the central arterial viscosity was not changed by the training. Therefore, this study suggests that the improvement of central arterial viscosity may need relative longer term of aerobic exercise, but shorter such a 10-week. - Flexibility and arterial stiffness
Grant-in-Aid for Young Scientists (B)
Waseda University
Apr. 2007 - Mar. 2009
■Achievement List
Lectures, oral presentations, etc.
- Daily physical activity enhances efficacy of treatment with SGLT2 inhibitors in patients with type 2 diabetes
Kenta Yamamoto|Riko Kai|Masaki Mizuno, 28th Annual Congress of the European College of Sport Science, 05 Jul. 2023, 04 Jul. 2023 - 07 Jul. 2023, Not exist, English, France, International conferences, Poster sessions, Paris
Url - 29 Oct. 2022, Japanese, Japan
Url
■University education and qualification information
