Anatase and rutile titanium oxide nanoparticles induce acute kidney injury by coadministration with paraquat, cisplatin or 5-aminosalicylic acid.
H Kamiyama; C Nonaka; H Saitoh; M Ohno; Y Shimizu; K Isoda
Die Pharmazie, 29 Feb. 2024, [Reviewed]
Nanoparticles are used in a variety of fields; for example, titanium oxide nanoparticles are used in paints, food additives, cosmetics, and sunscreen materials. Although the use of titanium oxide nanoparticles is regulated, their safety has not been established. Furthermore, the interaction between titanium oxide nanoparticles and various chemical substances and pharmaceuticals is unknown. We co-administered rutile-type titanium oxide nanoparticles (nTR) or anatase-type titanium oxide nanoparticles (nTA) to mice together with paraquat (PQ), cisplatin (CDDP), or anti-5-aminosalicylic acid (5-ASA), and investigated the extent, if any, of liver and kidney injury. As a result, when nTA and nTR were administered alone, no increases were observed in aspartate aminotransferase (AST) and alanine aminotransferase (ALT), which are indicators of liver damage, or urea nitrogen (BUN), which is an indicator of kidney damage. Next, nTA and nTR were co-administered with PQ, CDDP or 5-ASA. Although no increase in ALT or AST was observed, BUN levels increased significantly and acute kidney injury was induced. The findings suggested that titanium oxide nanoparticles induce acute kidney injury through their interaction with chemicals and drugs.

The mechanosensitive channel YbdG from Escherichia coli has a role in adaptation to osmotic up-shock
Shun Amemiya; Hayato Toyoda; Mami Kimura; Hiromi Saito; Hiroshi Kobayashi; Kunio Ihara; Kiyoto Kamagata; Ryuji Kawabata; Setsu Kato; Yutaka Nakashimada; Tadaomi Furuta; Shin Hamamoto; Nobuyuki Uozumi
Journal of Biological Chemistry, Aug. 2019, [Reviewed]

Effect of simvastatin on immune cells under alkaline and acidic conditions.　　　　　　　　　　　　　　　
Fukamachi, T.; Saito, H.; Kobayashi, H.
J. Cancer Sci. Ther., 2015, [Reviewed]

Expression of acidosis-dependent genes in human cancer nests.　　　　　　　　　　　　　　　
Fukamachi, T.; Ikeda, S.; Saito, H.; Tagawa, M.; Kobayashi, H.
Mol. Clin. Oncol, 2014, [Reviewed]

Acidic environments enhance the inhibitory effect of statins on proliferation of synovial cells.　　　　　　　　　　　　　　　
Fukamachi, T.; Wang, X.; Mochizuki Y.; Maruyama C.; Saito, H.; Kobayashi, H.
Int. Immunopharmacol., Jun. 2013, [Reviewed]

Gene expressions for signal transduction under acidic conditions.　　　　　　　　　　　　　　　
Fukamachi, T.; Ikeda, S.; Wang, X.; Saito; H. Tagawa, M.; Kobayashi, H.
Genes, Mar. 2013, [Reviewed]

TCR Signaling via ZAP-70 Induced by CD3 Stimulation is More Active Under Acidic Conditions
Wang, X., Hatatani, K., Sun, Y., Fukamachi, T., Saito, H. and Kobayashi, H.
Journal of Cell Science & Therapy, 2013, [Reviewed]

Respiration and the F1Fo-ATPase Enhance Survival under Acidic Conditions in Escherichia coli
Yirong Sun; Toshihiko Fukamachi; Hiromi Saito; Hiroshi Kobayashi
PLoS ONE, 28 Dec. 2012, [Reviewed]

Adenosine deamination increases the survival under acidic conditions in Escherichia coli
Y. Sun; T. Fukamachi; H. Saito; H. Kobayashi
JOURNAL OF APPLIED MICROBIOLOGY, Apr. 2012, [Reviewed]

ATP requirement for acidic resistance in Escherichia coli.　　　　　　　　　　　　　　　
Sun, Y.; Fukamachi, T.; Saito, H.; Kobayashi, H.
J. Bacteriol., Jun. 2011, [Reviewed]

Expression and Activity of Kdp under Acidic Conditions in Escherichia coli
Yan Hongwei; Fukamachi Toshihiko; Saito Hiromi; Kobayashi Hiroshi
Biological and Pharmaceutical Bulletin, 2011, [Reviewed]
Escherichia coli has three major K+ uptake systems, Trk, Kup, and Kdp, which have been studied extensively at near neutral pH. However, the function of these transporters under acidic conditions is not well understood, although growth and survival under acidic conditions are important for bacterial pathogenesis. In this study, we examined the expression and activity of Kdp under acidic conditions and found that the transport activity of Kdp is decreased at low pH and that the expression of kdp is regulated by the internal K+ concentration in a pH-independent manner. Consequently, the low activity of Kdp was compensated for by the induction of its elevated expression by low K+ accumulation via Kdp at acidic pH.

The Role of OmpC and OmpF in Acidic Resistance in Escherichia coli
Bekhit Amany; Fukamachi Toshihiko; Saito Hiromi; Kobayashi Hiroshi
Biological and Pharmaceutical Bulletin, 2011, [Reviewed]
The roles of OmpC and OmpF in acidic resistance (AR) were examined. When ompC and ompF were deleted, AR was decreased. The decreased level of AR seen in the mutant that was deficient in ompC and ompF was elevated by the addition of glutamate, but not by the addition of arginine or lysine. The expression levels of adiA and cadB were diminished by the deletion of ompC and ompF, and the conversion of arginine to agmatine and lysine to cadaverine by intact cells were reduced in the mutant. The expression of gadA/gadB was not affected by the deletion of ompC and ompF. These results suggest that the transport of arginine, lysine, and their decarboxylated products through OmpC and/or OmpF is essential for the survival of Escherichia coli cells under extremely acidic conditions.

Tumor specific low pH environments enhance the cytotoxicity of lovastatin and cantharidin.　　　　　　　　　　　　　　　
Fukamachi, T.; Chiba, Y.; Wang, X.; Saito, H.; Tagawa, M.; Kobayashi, H.
Cancer Lett., Nov. 2010, [Reviewed]

HU participates in expression of a specific set of genes required for growth and survival at acidic pH in Escherichia coli.　　　　　　　　　　　　　　　
Bi, H.; Sun, L.; Fukamachi, T.; Saito, H.; Kobayashi, H.
Curr. Microbiol., May 2009, [Reviewed]

Extracellular acidic environments induce phosphorylation of ZAP-70 in Jurkat T cells.　　　　　　　　　　　　　　　
Hirata, S.; Fukamachi, T.; Sakano, H.; Tarora, A.; Saito, H.; Kobayashi, H.
Immunol. Lett., Jan. 2008, [Reviewed]

Requirement of an I kappa B-beta COOH terminal region protein for acidic-adaptation in CHO cells
QZ Lao; T Fukamachi; H Saito; O Kuge; M Nishijima; H Kayashi
JOURNAL OF CELLULAR PHYSIOLOGY, Apr. 2006, [Reviewed]

OmpC and OmpF are required for growth under hyperosmotic stress above pH 8 in Escherichia coli
M Kaeriyama; K Machida; A Kitakaze; H Wang; Q Lao; T Fukamachi; H Saito; H Kobayashi
LETTERS IN APPLIED MICROBIOLOGY, Mar. 2006, [Reviewed]

CTIB (C-terminus protein of I kappa B-beta): A novel factor required for acidic adaptation
Fukamachi, T.; Lao, Q.; Okamura, S.; Saito, H.; Kobayashi, H.
Adv. Exp. Med. Biol., 2006

Carbon dioxide increases acid resistance in Escherichia coli
L. Sun; T. Fukamachi; H. Saito; H. Kobayashi
LETTERS IN APPLIED MICROBIOLOGY, Jun. 2005, [Reviewed]

An I kappa B-beta COOH terminal region protein is essential for the proliferation of CHO cells under acidic stress
QZ Lao; L Kuge; T Fukamachi; F Kakegawa; H Saito; M Nishijima; H Kobayashi
JOURNAL OF CELLULAR PHYSIOLOGY, Apr. 2005, [Reviewed]

Expression of chaA, a sodium ion extrusion system of Escherichia coli, is regulated by osmolarity and pH
T Shijuku; T Yamashino; H Ohashi; H Saito; T Kakegawa; M Ohta; H Kobayashi
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Dec. 2002, [Reviewed]

Membrane-bound ATPase contributes to hop resistance of Lactobacillus brevis
K Sakamoto; HW van Veen; H Saito; H Kobayashi; WN Konings
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Nov. 2002, [Reviewed]

Different proteins are phosphorylated under acidic environments in Jurkat cells
T Fukamachi; H Saito; T Kakegawa; H Kobayashi
IMMUNOLOGY LETTERS, Jun. 2002, [Reviewed]

Rapamycin induces binding activity to the terminal oligopyrimidine tract of ribosomal protein mRNA in rats
T Kakegawa; M Ito; A Hayakawa; M Matsuda; S Tamura; H Saito; RL Kaspar; H Kobayashi
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, Jun. 2002, [Reviewed]

Expression of sodium/proton antiporter NhaA at various pH values in Escherichia coli
T Shijuku; H Saito; T Kakegawa; H Kobayashi
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Nov. 2001, [Reviewed]

Ethylene glycol bis(beta-aminoethyl ether)-N,N,N ',N '-tetraacetic acid (EGTA) inhibits the growth of Escherichia coli at alkaline pH
Y Arakawa; T Saito; H Saito; T Kakegawa; H Kobayashi
JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY, Jun. 2000, [Reviewed]

Expression of outer membrane proteins in Escherichia coli growing at acid pH
M Sato; K Machida; E Arikado; H Saito; T Kakegawa; H Kobayashi
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Mar. 2000, [Reviewed]

Enzyme level of enterococcal F1F0-ATPase is regulated by pH at the step of assembly
E Arikado; H Ishihara; T Ehara; C Shibata; H Saito; T Kakegawa; K Igarashi; H Kobayashi
EUROPEAN JOURNAL OF BIOCHEMISTRY, Jan. 1999, [Reviewed]

Cloning and expression analysis of a cDNA coding for a dexamethasone-inducible cytochrome P450 in Xenopus laevis liver
H Ohi; E Sugata; Y Fujita; H Saito; K Saguchi; N Murayama; S Higuchi
BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL, Jul. 1998, [Reviewed]

pH dependence of the function of sodium ion extrusion systems in Escherichia coli
T Sakuma; N Yamada; H Saito; T Kakegawa; H Kobayashi
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Mar. 1998, [Reviewed]

Growth of an Escherichia coli mutant deficient in respiration
L Futatsugi; H Saito; T Kakegawa; H Kobayashi
FEMS MICROBIOLOGY LETTERS, Nov. 1997, [Reviewed]

Purification and characterization of a cytochrome P450 from liver microsomes of Xenopus laevis
H Saito; H Ohi; E Sugata; N Murayama; Y Fujita; S Higuchi
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, Sep. 1997, [Reviewed]

Cloning and sequence analysis of a Bothrops jararaca cDNA encoding a precursor of seven bradykinin-potentiating peptides and a C-type natriuretic peptide
N Murayama; MAF Hayashi; H Ohi; LAF Ferreira; VV Hermann; H Saito; Y Fujita; S Higuchi; BL Fernandes; T Yamane; ACM DeCamargo
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Feb. 1997, [Reviewed]

Purification and characterization of a hemocyte proteinase of Sarcophaga, possibly participating in elimination of foreign substances.
Saito, H.; Kurata, S.; Natori, S.
EUROPEAN JOURNAL OF BIOCHEMISTRY, Nov. 1992, [Reviewed]

The 29-kDa hemocyte proteinase dissociates fat body at metamorphosis of Sarcophaga.
Kurata, S.; Saito, H.; Natori, S.
DEVELOPMENTAL BIOLOGY, Sep. 1992, [Reviewed]

Purification of a 29-kDa hemocyte proteinase of Sarcophaga peregrina.
Kurata, S.; Saito, H.; Natori, S.
EUROPEAN JOURNAL OF BIOCHEMISTRY, Mar. 1992, [Reviewed]

Participation of hemocyte proteinase in dissociation of the fat body on pupation of Sarcophaga peregrina (flesh fly).
Kurata, S.; Saito, H.; Natori, S.
INSECT BIOCHEMISTRY, 1990, [Reviewed]

Molecular cloning of cDNA for sarcocystatin A and analysis of the expression of the sarcocystatin A gene during development of Sarcophaga peregrina.
Saito, H.; Suzuki, T.; Ueno, K.; Kubo, T.; Natori, S.
BIOCHEMISTRY, Feb. 1989, [Reviewed]

Reviving Previous Therapeutics by Recombinant Anaerobic Bifidobacteria
Taira, I.; Taira, Y.; Kato, M.; Shimizu, Y.; Isoda, K.; Saitou, H.; Ishida, I.
Biomedical Journal of Scientific & Technical Research, 09 Jan. 2019
Biomedical Research Network, LLC

Bacterial responses to alkaline stress.　　　　　　　　　　　　　　　
Saito, H.; Kobayashi, H.
2003

Bacterial strategies to inhabit acidic environments.
Kobayashi, H.; Saito, H.; Kakegawa, T.
JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY, Oct. 2000

Cation movements at alkaline pH in bacteria growing without respiration.
Hiroshi Kobayashi; Hiromi Saito; Lui Futatsugi; Tomohito Kakegawa
Bacterial responses to pH., 1999