Yoshikuni Goto
| Faculty of Pharmaceutical Sciences,Department of Pharmaceutical Sciences | Associate Professor |
Last Updated :2025/06/19
■Researcher basic information
Field Of Study
■Career
Career
- Apr. 2016 - Present
Teikyo Heisei University, Faculty of Pharmaceutical Sciences, 准教授 - Apr. 2014 - Mar. 2016
Teikyo Heisei University, Faculty of Pharmaceutical Sciences, 講師 - Apr. 2010 - Mar. 2014
Teikyo Heisei University, Faculty of Pharmaceutical Sciences, 助教 - Apr. 2007 - Mar. 2010
理化学研究所, 細胞生化学研究室, 基礎科学特別研究員
Educational Background
■Research activity information
Paper
- Distinguishing two distinct types of salivary extracellular vesicles: a potential tool for understanding their pathophysiological roles.
Yuko Ogawa; Yuri Miura; Mamoru Ikemoto; Atsushi Ohnishi; Yoshikuni Goto; Kazuma Aoki; Yuki Motokurumada; Yoshihiro Akimoto; Tamao Endo; Masafumi Tsujimoto; Ryohei Yanoshita
Frontiers in molecular biosciences, 2024 - Diurnal variations of triglyceride accumulation in mouse and bovine adipocyte‐derived cell lines
Rena Shiraishi; Satomi Morita; Yoshikuni Goto; Yasushi Mizoguchi; Wataru Nakamura; Takahiro J. Nakamura
Animal Science Journal, Jan. 2022 - Stability of human salivary extracellular vesicles containing dipeptidyl peptidase IV under simulated gastrointestinal tract conditions.
Yuko Ogawa; Yoshihiro Akimoto; Mamoru Ikemoto; Yoshikuni Goto; Anna Ishikawa; Sakura Ohta; Yumi Takase; Hayato Kawakami; Masafumi Tsujimoto; Ryohei Yanoshita
Biochemistry and biophysics reports, Sep. 2021 - Molecular and functional diversity of the oxytocinase subfamily of M1 aminopeptidases.
Masafumi Tsujimoto; Kazuma Aoki; Yoshikuni Goto; Atsushi Ohnishi
Journal of biochemistry, 29 Apr. 2021 - Reciprocal Expression Patterns of Placental Leucine Aminopeptidase/Insulin-Regulated Aminopeptidase and Vasopressin in the Murine Brain.
Yoshikuni Goto; Takahiro J Nakamura; Kenji Ogawa; Akira Hattori; Masafumi Tsujimoto
Frontiers in molecular biosciences, 24 Jul. 2020, [Reviewed] - Endoplasmic Reticulum Aminopeptidase 1 beyond Antigenic Peptide-Processing Enzyme in the Endoplasmic Reticulum.
Masafumi Tsujimoto; Kazuma Aoki; Atsushi Ohnishi; Yoshikuni Goto
Biological & pharmaceutical bulletin, 2020, [Reviewed] - Acute-phase protein-like properties of endoplasmic reticulum aminopeptidase 1.
Yoshikuni Goto; Takahiro J Nakamura; Kenji Ogawa; Akira Hattori; Masafumi Tsujimoto
Journal of biochemistry, 01 Feb. 2019 - Contribution of the exosome-associated form of secreted endoplasmic reticulum aminopeptidase 1 to exosome-mediated macrophage activation.
Yoshikuni Goto; Yuko Ogawa; Hiroki Tsumoto; Yuri Miura; Takahiro J Nakamura; Kenji Ogawa; Yoshihiro Akimoto; Hayato Kawakami; Tamao Endo; Ryohei Yanoshita; Masafumi Tsujimoto
Biochimica et biophysica acta. Molecular cell research, Jun. 2018 - A Single Neonatal Injection of Ethinyl Estradiol Impairs Passive Avoidance Learning and Reduces Expression of Estrogen Receptor α in the Hippocampus and Cortex of Adult Female Rats.
Tatsuomi Shiga; Takahiro J Nakamura; Chiaki Komine; Yoshikuni Goto; Yasushi Mizoguchi; Midori Yoshida; Yasuhiko Kondo; Maiko Kawaguchi
PloS one, Jan. 2016 - Involvement of Phenylalanine 297 in the Construction of the Substrate Pocket of Human Aminopeptidase B.
Atsushi Ohnishi; Jobu Watanabe; Yuko Ogawa; Yoshikuni Goto; Akira Hattori; Masafumi Tsujimoto
Biochemistry, 06 Oct. 2015 - Substrate-dependent nitric oxide synthesis by secreted endoplasmic reticulum aminopeptidase 1 in macrophages.
Yoshikuni Goto; Kenji Ogawa; Takahiro J Nakamura; Akira Hattori; Masafumi Tsujimoto
Journal of biochemistry, Jun. 2015, [Reviewed] - Role of glutamine-169 in the substrate recognition of human aminopeptidase B.
Yuko Ogawa; Atsushi Ohnishi; Yoshikuni Goto; Yoshiki Sakuma; Jobu Watanabe; Akira Hattori; Masafumi Tsujimoto
Biochimica et biophysica acta, Jun. 2014, [Reviewed] - Role of glutamine-169 in the substrate recognition of human aminopeptidase B
Yuko Ogawa; Atsushi Ohnishi; Yoshikuni Goto; Yoshiki Sakuma; Jobu Watanabe; Akira Hattori; Masafumi Tsujimoto
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, Jun. 2014 - TLR-mediated secretion of endoplasmic reticulum aminopeptidase 1 from macrophages.
Yoshikuni Goto; Kenji Ogawa; Takahiro J Nakamura; Akira Hattori; Masafumi Tsujimoto
Journal of immunology (Baltimore, Md. : 1950), 01 May 2014 - Exon 10 coding sequence is important for endoplasmic reticulum retention of endoplasmic reticulum aminopeptidase 1.
Akira Hattori; Yoshikuni Goto; Masafumi Tsujimoto
Biological & pharmaceutical bulletin, Apr. 2012 - Secretion of endoplasmic reticulum aminopeptidase 1 is involved in the activation of macrophages induced by lipopolysaccharide and interferon-gamma.
Yoshikuni Goto; Kenji Ogawa; Akira Hattori; Masafumi Tsujimoto
The Journal of biological chemistry, 17 Jun. 2011 - Cutting Edge: Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzyme.
Irini Evnouchidou; Ram P Kamal; Sergey S Seregin; Yoshikuni Goto; Masafumi Tsujimoto; Akira Hattori; Paraskevi V Voulgari; Alexandros A Drosos; Andrea Amalfitano; Ian A York; Efstratios Stratikos
Journal of immunology (Baltimore, Md. : 1950), 15 Feb. 2011 - Involvement of glutamine-238 in the substrate specificity of human laeverin/aminopeptidase Q.
Yoshikuni Goto; Rina Yoshioka; Naomi Arisaka; Akira Hattori; Masafumi Tsujimoto
Biological & pharmaceutical bulletin, Jan. 2011 - Histidine 379 of human laeverin/aminopeptidase Q, a nonconserved residue within the exopeptidase motif, defines its distinctive enzymatic properties.
Masato Maruyama; Naomi Arisaka; Yoshikuni Goto; Yosuke Ohsawa; Hideshi Inoue; Hiroshi Fujiwara; Akira Hattori; Masafumi Tsujimoto
The Journal of biological chemistry, 11 Dec. 2009 - Glutamine-181 is crucial in the enzymatic activity and substrate specificity of human endoplasmic-reticulum aminopeptidase-1.
Yoshikuni Goto; Hiroe Tanji; Akira Hattori; Masafumi Tsujimoto
The Biochemical journal, 15 Nov. 2008 - Biochemical and enzymatic properties of the M1 family of aminopeptidases involved in the regulation of blood pressure.
Masafumi Tsujimoto; Yoshikuni Goto; Masato Maruyama; Akira Hattori
Heart failure reviews, Sep. 2008 - Asparatic acid 221 is critical in the calcium-induced modulation of the enzymatic activity of human aminopeptidase A.
Yoshikuni Goto; Akira Hattori; Shigehiko Mizutani; Masafumi Tsujimoto
The Journal of biological chemistry, 21 Dec. 2007 - Laeverin/aminopeptidase Q, a novel bestatin-sensitive leucine aminopeptidase belonging to the M1 family of aminopeptidases.
Masato Maruyama; Akira Hattori; Yoshikuni Goto; Masamichi Ueda; Michiyuki Maeda; Hiroshi Fujiwara; Masafumi Tsujimoto
The Journal of biological chemistry, 13 Jul. 2007 - Enzymatic properties of human aminopeptidase A. Regulation of its enzymatic activity by calcium and angiotensin IV.
Yoshikuni Goto; Akira Hattori; Yasuhiro Ishii; Shigehiko Mizutani; Masafumi Tsujimoto
The Journal of biological chemistry, 18 Aug. 2006, [Reviewed] - Reduced activity of the hypertension-associated Lys528Arg mutant of human adipocyte-derived leucine aminopeptidase (A-LAP)/ER-aminopeptidase-1.
Yoshikuni Goto; Akira Hattori; Yasuhiro Ishii; Masafumi Tsujimoto
FEBS letters, 20 Mar. 2006, [Reviewed] - 2-5A induces a conformational change in the ankyrin-repeat domain of RNase L.
Masayuki Nakanishi; Yoshikuni Goto; Yukio Kitade
Proteins, 01 Jul. 2005, [Reviewed] - Crystallization of the N-terminal ankyrin repeat domain of the 2-5A-dependent endoribonuclease, RNase L.
Nobutada Tanaka; Masayuki Nakanishi; Yoshio Kusakabe; Yoshikuni Goto; Yukio Kitade; Kazuo T Nakamura
Protein and peptide letters, May 2005, [Reviewed] - Molecular basis for recognition of 2',5'-linked oligoadenylates by the N-terminal ankyrin repeat domain of human ribonuclease L.
Nobutada Tanaka; Masayuki Nakanishi; Yoshio Kusakabe; Yoshikuni Goto; Yukio Kitade; Kazuo T Nakamura
Nucleic acids symposium series (2004), 2005, [Reviewed] - Structural basis for recognition of 2',5'-linked oligoadenylates by human ribonuclease L.
Nobutada Tanaka; Masayuki Nakanishi; Yoshio Kusakabe; Yoshikuni Goto; Yukio Kitade; Kazuo T Nakamura
The EMBO journal, 13 Oct. 2004, [Reviewed]
MISC
- LPS-binding proteins in human salivary extracellular vesicles regulate the activation of macrophages.
小川裕子; 三浦ゆり; 後藤芳邦; 池本守; 秋元義弘; 遠藤玉夫; 矢ノ下良平
日本薬学会年会要旨集(Web), 2023 - Avoidance of host innate immunity by variant surface glycoprotein in Trypanosoma brucei
後藤芳邦; 野元裕; 辻本雅文; 中西雅之
日本寄生虫学会大会プログラム・抄録集, 2022 - Molecular mechanism of mammalian host innate immune evasion of Trypanosoma brucei
石毛奈桜; 後藤芳邦; 野元裕; 辻本雅文; 中西雅之
日本分子生物学会年会プログラム・要旨集(Web), 2022 - Dysfuction of ER-aminopeptidase 1 induce serotonin-dependent anxiety
平井杏奈; 鈴木優香; 中村孝博; 小川健司; 服部明; 辻本雅文; 後藤芳邦
日本分子生物学会年会プログラム・要旨集(Web), 2022 - Specification of extracellular vesicles characterized by their membrane proteins, APN/mucin1 or DPP IV/CD9
小川裕子; 三浦ゆり; 大西敦; 後藤芳邦; 青木一真; 池本守; 本車田悠希; 堤周平; 長島茉央; 廣谷莉花; 武井亮太朗; 秋元義弘; 遠藤玉夫; 矢ノ下良平
日本唾液腺学会誌, Nov. 2022 - Trypanosoma bruceiに対する宿主マクロファージの生体防御反応
後藤 芳邦; 辻本 雅文; 野元 裕; 中西 雅之
日本寄生虫学会・日本臨床寄生虫学会合同大会プログラム・抄録集, Apr. 2021 - Stability of human salivary extracellular vesicles under simulated gastric and intestinal conditions
小川裕子; 石川杏奈; 太田櫻; 池本守; 後藤芳邦; 秋元義弘; 川上速人; 辻本雅文; 矢ノ下良平
日本薬学会年会要旨集(Web), Mar. 2021 - Activation of macrophages by variant surface glycoprotein from Trypanosoma brucei in vitro
後藤芳邦; 津元裕樹; 三浦ゆり; 遠藤玉夫; 野元裕; 辻本雅文; 中西雅之
日本寄生虫学会大会プログラム・抄録集, 2020 - 小胞体アミノペプチダーゼ1遺伝子欠損は、セロトニン合成を亢進することで不安を誘発する
斎藤 朱里; 後藤 芳邦; 中村 孝博; 小川 健司; 服部 明; 辻本 雅文
日本生化学会大会プログラム・講演要旨集, Sep. 2019 - 小胞体アミノペプチダーゼ1遺伝子欠損はセロトニン合成亢進を介して不安障害を惹起する
小林 春奈; 後藤 芳邦; 中村 孝博; 小川 健司; 服部 明; 辻本 雅文
日本薬学会年会要旨集, Mar. 2019 - ヒト唾液由来exosomeの表面分子の結合状態および免疫活性化の制御への関与
小川 裕子; 粂田 奈宝子; 後藤 芳邦; 辻本 雅文; 秋元 義弘; 川上 速人; 矢ノ下 良平
日本唾液腺学会誌, Nov. 2018 - マクロファージ活性化に関与するヒト唾液由来エキソソーム表面分子の解析
小川 裕子; 池本 守; 村上 舞; 本車田 悠希; 吉川 侑; 粂田 奈宝子; 後藤 芳邦; 辻本 雅文; 秋元 義弘; 川上 速人; 矢ノ下 良平
日本薬学会年会要旨集, Mar. 2018 - ヒト唾液由来エキソソームの表面分子によるマクロファージ活性化機構の解析
小川裕子; 伊藤芹奈; 池本守; 粂田奈宝子; 後藤芳邦; 辻本雅文; 秋元義弘; 川上速人; 矢ノ下良平
日本薬学会関東支部大会講演要旨集, 2018 - ヒト唾液由来エキソソームの表面に存在する分子は免疫活性化作用を制御する
小川 裕子; 村上 舞; 本車田 悠希; 吉川 侑; 市川 結樹; 陰山 采夏; 鈴木 恵理香; 平山 碧穂; 粂田 奈宝子; 後藤 芳邦; 辻本 雅文; 秋元 義弘; 川上 速人; 矢ノ下 良平
生命科学系学会合同年次大会, Dec. 2017 - ERAP1結合型エキソソームによるマクロファージの古典的活性化
後藤芳邦; 小川裕子; 津元裕樹; 三浦ゆり; 中村孝博; 小川健司; 服部明; 秋元義弘; 川上速人; 遠藤玉夫; 矢ノ下良平; 辻本雅文
日本生化学会大会(Web), 2017 - 細菌感染に伴い血中に分泌されたERAP1は血中アミノ酸や一酸化窒素濃度を調節する
後藤芳邦; 小川健司; 中村孝博; 青嶋瑞樹; 荒俣晃貴; 高田慧; 町田綾乃; 吉野僚太; 服部明; 辻本雅文
日本生化学会大会(Web), 2015 - 生後24時間以内のethinyl estradiol曝露は成熟後の脳内ERα発現量を減少させる
志賀 健臣; 中村 孝博; 小峰 千亜希; 神島 愛未; 後藤 芳邦; 吉田 緑; 近藤 保彦; 溝口 康; 川口 真以子
環境ホルモン学会研究発表会要旨集, Dec. 2013 - M1アミノペプチダーゼファミリーの生理的/病理学的機能
服部明; 服部明; 丸山正人; 後藤芳邦; 辻本雅文
ケミカルバイオロジーシンポジウム発表要旨集 第4回 化学-生物融合領域創成の軌跡 理研シンポジウム 平成20年, 2008 - アミノペプチダーゼAのAsp-221残基はCa2+によるアミノペプチダーゼ活性の調節に必須である
後藤芳邦; 服部明; 辻本雅文
ケミカルバイオロジーシンポジウム発表要旨集 第4回 化学-生物融合領域創成の軌跡 理研シンポジウム 平成20年, 2008 - ヒトリボヌクレアーゼLのN末端アンキリンリピートドメインと2‐5Aとの複合体の結晶構造
田中信忠; 中西雅之; 日下部吉男; 後藤芳邦; 北出幸夫; 中村和郎
日本薬学会年会要旨集, 05 Mar. 2005 - 2‐5Aシステムの鍵酵素ヒトリボヌクレアーゼLによる2‐5A認識
田中信忠; 中西雅之; 日下部吉男; 後藤芳邦; 北出幸夫; 中村和郎
日本分子生物学会年会プログラム・講演要旨集, 25 Nov. 2004 - Application of cryopreserved spleen cells to a monoclonal antibody production.
山川文徳; 後藤芳邦
和歌山工業高等専門学校研究紀要, 2000
Research Themes
- Dysfunction of ERAP1 induces anxiety disorder via excess serotonin synthesis
Grant-in-Aid for Scientific Research (C)
Teikyo Heisei University
01 Apr. 2019 - 31 Mar. 2022 - Mechanism of mucosal immunity activation by exosome
Grant-in-Aid for Scientific Research (C)
Teikyo Heisei University
21 Oct. 2016 - 31 Mar. 2019 - Roles of ER aminopeptidase 1 in inflammation of Behcet's disease
Grant-in-Aid for Scientific Research (C)
Teikyo Heisei University
01 Apr. 2016 - 31 Mar. 2019 - Role of ERAP1 in the pathogenesis of mental disorders
Grant-in-Aid for Challenging Exploratory Research
Teikyo Heisei University
01 Apr. 2015 - 31 Mar. 2017 - Molecular mechanism and regulation of immune activation cascade by aminopeptidase contained exosome.
Grant-in-Aid for Scientific Research (C)
Teikyo Heisei University
01 Apr. 2013 - 31 Mar. 2016 - Pathophysiological roles of M1 aminopeptidases
Grant-in-Aid for Scientific Research (B)
Teikyo Heisei University
01 Apr. 2013 - 31 Mar. 2016 - Contribution of ER-aminopeptidase secretion to classical activation of macrophages
Grant-in-Aid for Young Scientists (B)
Teikyo Heisei University
01 Apr. 2012 - 31 Mar. 2015 - Role of aminopeptidases in atherosclerosis
Grant-in-Aid for Challenging Exploratory Research
Teikyo Heisei University
Apr. 2012 - Mar. 2014 - Regulation of blood pressure by secreted adipocyte-derived leucine aminopeptidase
Grant-in-Aid for Young Scientists (B)
Apr. 2009 - Mar. 2011 - Mechanisms of Enzymatic Action of the Oxytocinase Subfamily of Aminopeptidases
Grant-in-Aid for Scientific Research (B)
The Institute of Physical and Chemical Research
2006 - 2008 - 脂肪細胞由来ロイシンアミノペプチダーゼの分泌を介した新規血圧調節作用の機構解明と高血圧療法への応用
2008
