Yuko Ogawa
| Faculty of Pharmaceutical Sciences,Department of Pharmaceutical Sciences | Associate Professor |
Last Updated :2025/06/19
■Researcher basic information
■Career
Career
- Apr. 2014 - Present
Teikyo Heisei University, Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Membrane biology, Associate professor - Apr. 2010 - Mar. 2014
Teikyo Heisei University, Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Lecturer - Apr. 2009 - Mar. 2010
Hoshi University, Institute of Medicinal Chemistry, Bioorganic Chemistry, Research associate - Apr. 2007 - Mar. 2009
Hoshi University, Institute of Medicinal Chemistry, Laboratory of Biological resources, Research associate - Oct. 2002 - Mar. 2007
Hoshi University, Institute of Medicinal Chemistry, Laboratory of Biological resources, Research assistant - Oct. 2001 - Sep. 2002
National Institute of Health Sciences, Division of Food Additives, 賃金職員 - Apr. 1994 - Jul. 2001
Hoshi University, Department of pharmacy, Laboratory of microbiology, Research assistant
Member History
■Research activity information
Award
- Nov. 2024
NPO法人 日本唾液ケア研究会, 唾液関連優秀論文賞 - Aug. 2017
The Pharmaceutical Society of Japan, Highlighted Paper selected by Editor-in-Chief
Characterization of Membrane Integrity and Morphological Stability of Human Salivary Exosomes.
Kumeda N;Ogawa Y;Akimoto Y;Kawakami H;Tsujimoto M;Yanoshita R - Dec. 2016
日本唾液腺学会, 奨励賞
ヒト唾液由来の2種類のエキソソームに含まれるRNAの次世代シーケンサーによる網羅的解析
小川裕子;辻本雅文;矢ノ下良平 - Sep. 2016
The Pharmaceutical Society of Japan, Highlighted Paper selected by Editor-in-Chief
Next-Generation Sequencing of Protein-coding and Long Non-protein-coding RNAs in Two Types of Exosomes Derived from Human Whole Saliva
Ogawa Y;Tsujimoto M;Yanoshita R - Dec. 2009
日本唾液腺学会, 奨励賞
ヒト唾液中に存在する2種類のエキソソームの性状解析
小川裕子;金井正美;三浦ゆり;原園 景;秋元義弘;川上速人;戸田年総;遠藤玉夫;山口照英;津吹政可;矢ノ下良平
Paper
- Distinguishing two distinct types of salivary extracellular vesicles: a potential tool for understanding their pathophysiological roles.
Yuko Ogawa; Yuri Miura; Mamoru Ikemoto; Atsushi Ohnishi; Yoshikuni Goto; Kazuma Aoki; Yuki Motokurumada; Yoshihiro Akimoto; Tamao Endo; Masafumi Tsujimoto; Ryohei Yanoshita
Frontiers in molecular biosciences, 2024, [Reviewed]
Lead, Corresponding - Stability of human salivary extracellular vesicles containing dipeptidyl peptidase IV under simulated gastrointestinal tract conditions
Yuko Ogawa; Yoshihiro Akimoto; Mamoru Ikemoto; Yoshikuni Goto; Anna Ishikawa; Sakura Ohta; Yumi Takase; Hayato Kawakami; Masafumi Tsujimoto; Ryohei Yanoshita
Biochemistry and Biophysics Reports, Sep. 2021, [Reviewed]
Lead, Corresponding - Contribution of the exosome-associated form of secreted endoplasmic reticulum aminopeptidase 1 to exosome-mediated macrophage activation
Yoshikuni Goto; Yuko Ogawa; Hiroki Tsumoto; Yuri Miura; Takahiro J. Nakamura; Kenji Ogawa; Yoshihiro Akimoto; Hayato Kawakami; Tamao Endo; Ryohei Yanoshita; Masafumi Tsujimoto
Biochimica et Biophysica Acta - Molecular Cell Research, 01 Jun. 2018, [Reviewed] - Characterization of Membrane Integrity and Morphological Stability of Human Salivary Exosomes
Nahoko Kumeda; Yuko Ogawa; Yoshihiro Akimoto; Hayato Kawakami; Masafumi Tsujimoto; Ryohei Yanoshita
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Aug. 2017, [Reviewed] - Migration of nonylphenol and plasticizers from polyvinyl chloride stretch film into food simulants, rapeseed oil, and foods
Yoko Kawamura; Yuko Ogawa; Motoh Mutsuga
FOOD SCIENCE & NUTRITION, May 2017, [Reviewed] - Next-Generation Sequencing of Protein-Coding and Long Non-protein-Coding RNAs in Two Types of Exosomes Derived from Human Whole Saliva
Yuko Ogawa; Masafumi Tsujimoto; Ryohei Yanoshita
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Sep. 2016, [Reviewed]
Lead, Corresponding - Involvement of Phenylalanine 297 in the Construction of the Substrate Pocket of Human Aminopeptidase B
Atsushi Ohnishi; Jobu Watanabe; Yuko Ogawa; Yoshikuni Goto; Akira Hattori; Masafumi Tsujimoto
BIOCHEMISTRY, Oct. 2015, [Reviewed] - Role of glutamine-169 in the substrate recognition of human aminopeptidase B
Yuko Ogawa; Atsushi Ohnishi; Yoshikuni Goto; Yoshiki Sakuma; Jobu Watanabe; Akira Hattori; Masafumi Tsujimoto
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, Jun. 2014, [Reviewed]
Lead - Small RNA Transcriptomes of Two Types of Exosomes in Human Whole Saliva Determined by Next Generation Sequencing
Yuko Ogawa; Yoshitaka Taketomi; Makoto Murakami; Masafumi Tsujimoto; Ryohei Yanoshita
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Jan. 2013, [Reviewed]
Lead - Proteomic Analysis of Two Types of Exosomes in Human Whole Saliva
Yuko Ogawa; Yuri Miura; Akira Harazono; Masami Kanai-Azuma; Yoshihiro Akimoto; Hayato Kawakami; Teruhide Yamaguchi; Tosifusa Toda; Tamao Endo; Masayoshi Tsubuki; Ryohei Yanoshita
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Jan. 2011, [Reviewed]
Lead - Selective accumulation of a novel antimalarial rhodacyanine derivative, SSJ-127, in an organelle of Plasmodium berghei
Mayumi Ikegami-Kawai; Chika Arai; Yuko Ogawa; Ryohei Yanoshita; Masataka Ihara
BIOORGANIC & MEDICINAL CHEMISTRY, Nov. 2010, [Reviewed] - Molecular cloning and characterization of ecto-5 '-nucleotidase from the venoms of Gloydius blomhoffi
Yuko Ogawa; Nobuhiro Murayama; Ryohei Yanoshita
TOXICON, Sep. 2009, [Reviewed]
Lead - Exosome-like vesicles with dipeptidyl peptidase IV in human saliva
Yuko Ogawa; Masami Kanai-Azuma; Yoshihiro Akimoto; Hayato Kawakami; Ryohel Yanoshita
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Jun. 2008, [Reviewed]
Lead - Exosome-like vesicles in Gloydius blomhoffii blomhoffii venom
Yuko Ogawa; Masami Kanai-Azuma; Yoshihiro Akimoto; Hayato Kawakami; Ryohei Yanoshita
TOXICON, May 2008, [Reviewed]
Lead - Characterization and cDNA cloning of aminopeptidase A from the venom of Gloydius blomhoffi brevicaudus
Yuko Ogawa; Nobuhiro Murayama; Yoshiaki Fujita; Ryohel Yanoshita
TOXICON, Jun. 2007, [Reviewed]
Lead - Characterization and cDNA cloning of dipeptidyl peptidase IV from the venom of Gloydius blomhoffi brevicaudus
Yuko Ogawa; Yoshie Mamura; Nobuhiro Murayama; Ryohei Yanoshita
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, Sep. 2006, [Reviewed]
Lead - Estrogenic activities of chemicals related to food contact plastics and rubbers tested by the yeast two-hybrid assay
Y Ogawa; Y Kawamura; C Wakui; M Mutsuga; T Nishimura; K Tanamoto
FOOD ADDITIVES AND CONTAMINANTS, Apr. 2006, [Reviewed]
Lead - Molecular cloning of the major lethal toxins from two kraits (Bungarus flaviceps and Bungarus candidus)
R Yanoshita; Y Ogawa; N Murayama; T Omori-Satoh; K Saguchi; S Higuchi; O Khow; L Chanhome; Y Samejima; Sitprija, V
TOXICON, Mar. 2006, [Reviewed] - On a salmon (Onchorhynchus keta) liver RNase, belonging to RNase T2 family: Primary structure and some properties
R Suzuki; S Kanno; Y Ogawa; M Iwania; T Tsuji; K Ohgi; M Irie
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Feb. 2005, [Reviewed] - Complete amino acid sequence and phylogenetic analysis of a long-chain neurotoxin from the venom of the African banded water cobra, Boulengerina annulata
Y Ogawa; R Yanoshita; U Kuch; Y Samejima; D Mebs
TOXICON, Jun. 2004, [Reviewed]
Lead - Isolation, toxicity and amino terminal sequences of three major neurotoxins in the venom of Malayan krait (Bungarus candidus) from Thailand
O Khow; L Chanhome; T Omori-Satoh; Y Ogawa; R Yanoshita; Y Samejima; U Kuch; D Mebs; Sitprija, V
JOURNAL OF BIOCHEMISTRY, Dec. 2003, [Reviewed] - Estrogenic activities of UV stabilizers used in food contact plastics and benzophenone derivatives tested by the yeast two-hybrid assay
Y Kawamura; Y Ogawa; T Nishimura; Y Kikuchi; J Nishikawa; T Nishihara; K Tanamoto
JOURNAL OF HEALTH SCIENCE, Jun. 2003, [Reviewed] - Effect of replacing the aspartic acid/glutamic acid residues of bullfrog sialic acid binding lectin with asparagine/glutamine and arginine on the inhibition of cell proliferation in murine leukemia P388 cells
Y Ogawa; M Iwama; K Ohgi; T Tsuji; M Irie; T Itagaki; H Kobayashi; N Inokuchi
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Jun. 2002, [Reviewed]
Lead - Enzymatic properties of sialic acid binding lectin from Rana catesbeiana modified with a water-soluble carbodiimide in the presence of various nucleophiles
M Iwama; Y Ogawa; K Ohgi; T Tsuji; M Irie
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Dec. 2001, [Reviewed] - Effect of modification of the carboxyl groups of the sialic acid binding lectin from bullfrog (Rana catesbeiana) oocyte on anti-tumor activity
M Iwama; Y Ogawa; N Sasaki; K Nitta; Y Takayanagi; K Ohgi; T Tsuji; M Irie
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Sep. 2001, [Reviewed] - Amino acid sequence and characterization of a rice bran ribonuclease
M Iwama; Y Ogawa; M Yamagishi; T Itagaki; N Inokuchi; T Koyama; R Imai; K Ohgi; T Tsuji; M Irie
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Jul. 2001, [Reviewed] - A protease sensitive region of plant and animal ribonucleases belonging to the RNase T2 family
M Iwama; A Kusano; Y Ogawa; K Ohgi; M Irie
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Jun. 1998, [Reviewed] - Bovine spleen acid ribonuclease is a member of the RNase T2 family.
Narumi, H; Ogawa, Y; Iwama, M; Kusano, A; Sanda, A; Ohgi, K; Irie M
J. Biochem. Biol. & Biophys., 1997, [Reviewed] - Enzymatic activities of several K108 mutants of ribonuclease (RNase) isolated from Rhizopus niveus
K Ohgi; M Iwama; Y Ogawa; C Hagiwara; E Ono; R Kawaguchi; C Kanazawa; M Irie
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Aug. 1996, [Reviewed]
MISC
- LPS-binding proteins in human salivary extracellular vesicles regulate the activation of macrophages.
小川裕子; 三浦ゆり; 後藤芳邦; 池本守; 秋元義弘; 遠藤玉夫; 矢ノ下良平
日本薬学会年会要旨集(Web), 2023 - アミノペプチダーゼに着目したヒト唾液由来細胞外小胞の性状解析
小川 裕子; 池本 守; 三浦 ゆり; 津元 裕樹; 遠藤 玉夫; 本車田 悠希; 堤 周平; 長島 茉央; 松岡 千裕; 原 紅音; 秋元 義弘; 川上 速人; 矢ノ下 良平
日本薬学会年会要旨集, Mar. 2022 - Specification of extracellular vesicles characterized by their membrane proteins, APN/mucin1 or DPP IV/CD9
小川裕子; 三浦ゆり; 大西敦; 後藤芳邦; 青木一真; 池本守; 本車田悠希; 堤周平; 長島茉央; 廣谷莉花; 武井亮太朗; 秋元義弘; 遠藤玉夫; 矢ノ下良平
日本唾液腺学会誌, 2022 - Stability of human salivary extracellular vesicles under simulated gastric and intestinal conditions
小川裕子; 石川杏奈; 太田櫻; 池本守; 後藤芳邦; 秋元義弘; 川上速人; 辻本雅文; 矢ノ下良平
日本薬学会年会要旨集(Web), 2021 - マクロファージ活性化に関与するヒト唾液由来エキソソーム表面分子の解析
小川裕子; 池本守; 村上舞; 本車田悠希; 吉川侑; 粂田奈宝子; 後藤芳邦; 辻本雅文; 秋元義弘; 川上速人; 矢ノ下良平
日本薬学会年会要旨集(CD-ROM), 2018 - ヒト唾液由来エキソソームの表面分子によるマクロファージ活性化機構の解析
小川裕子; 伊藤芹奈; 池本守; 粂田奈宝子; 後藤芳邦; 辻本雅文; 秋元義弘; 川上速人; 矢ノ下良平
日本薬学会関東支部大会講演要旨集, 2018 - ヒト唾液由来エキソソームの表面に存在する分子は免疫活性化作用を制御する
小川裕子; 村上舞; 本車田悠希; 吉川侑; 市川結樹; 陰山采夏; 鈴木恵理香; 平山碧穂; 粂田奈宝子; 後藤芳邦; 辻本雅文; 秋元義弘; 川上速人; 矢ノ下良平
日本生化学会大会(Web), 2017 - ERAP1結合型エキソソームによるマクロファージの古典的活性化
後藤芳邦; 小川裕子; 津元裕樹; 三浦ゆり; 中村孝博; 小川健司; 服部明; 秋元義弘; 川上速人; 遠藤玉夫; 矢ノ下良平; 辻本雅文
日本生化学会大会(Web), 2017 - ヘビ毒の膜結合性酵素の性状解析とcDNAクローニング
小川 裕子; 村山 信浩; 矢ノ下 良平
日本薬学会年会要旨集, Mar. 2008 - タンビマムシ毒に含まれるアミノペプチダーゼの性状解析
小川 裕子; 矢ノ下 良平; 村山 信浩
日本薬学会年会要旨集, Mar. 2006 - 2種のアマガサ蛇の毒に含まれるβ-ブンガロトキシンのcDNAクローニング
小川 裕子; 村山 信浩; 佐口 健一; 矢ノ下 良平; 佐藤 保; 樋口 成定; 鮫島 勇次
日本薬学会年会要旨集, Mar. 2004 - 中国マムシ毒由来ジペプチジルアミノペプチダーゼIVの性状解析とcDNAクローニング
小川 裕子; 作田 朋子; 増井 由佳; 矢ノ下 良平; 村山 信浩; 樋口 成定; 鮫島 勇次
日本薬学会年会要旨集, Mar. 2004
Lectures, oral presentations, etc.
Affiliated academic society
Research Themes
- Development of autovaccine for periodontal disease using human salivary exosomes with immune activity
Grant-in-Aid for Scientific Research (C)
Teikyo Heisei University
Apr. 2020 - Mar. 2023 - エキソソームによる粘膜免疫賦活機構の解明
Apr. 2016 - Mar. 2019 - M1 アミノペプチダーゼ機能異常と自己免疫疾患病態の分子機構
Apr. 2013 - Mar. 2016 - アミノペプチダーゼ内包エキソソームによる免疫活性化カスケードの分子機構とその制御
Apr. 2013 - Mar. 2016 - 医薬品開発に応用できる生体成分由来ナノキャリアの開発
Oct. 2008 - Sep. 2009
■University education and qualification information
