Katsuhiro Isoda

Faculty of Pharmaceutical Sciences,Department of Pharmaceutical SciencesProfessor
Graduate School of Pharmaceutical Sciences,Doctoral Program in Pharmaceutical SciencesProfessor
Last Updated :2025/10/07

■Researcher basic information

Research Keyword

  • Regenerative Medicine
  • Nano Toxicology
  • Hepatology
  • Toxicology
  • Pharmacy

Field Of Study

  • Life sciences, Pharmaceuticals - health and biochemistry
  • Life sciences, Pharmacology

■Career

Educational Background

  • Mar. 2005

Member History

  • Oct. 2024 - Present

■Research activity information

Award

  • 2006
    Japan

Paper

MISC

Affiliated academic society

  • THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE　　　　　　　　　　　　　　　
  • THE JAPANESE SOCIETY OF TOXICOLOGY　　　　　　　　　　　　　　　
  • THE PHARMACEUTICAL SOCIETY OF JAPAN　　　　　　　　　　　　　　　

Works

  • ナノ粒子の薬物相互作用　　　　　　　　　　　　　　　
    01 Apr. 2008 - Present

Research Themes

  • Examination of nano-particles contained in food and food packaging material in mice with drugs or chemicals induced toxicity.
    Grant-in-Aid for Young Scientists (B)
    Teikyo Heisei University
    01 Apr. 2012 - 31 Mar. 2014
    Nanomaterials are used frequently in microelectronics, cosmetics and sunscreen, and research for the development of nanomaterial-based drug delivery systems is promising. Interactions between nano-size materials and drugs that have therapeutic potential need investigating. This research examined the safety of the nanoparticle contained in food or a food additive. The Result, silica nano-particles, clay nano-particles, silver nano-particles and platinum nano-particles did not have injury by oral administration to mice, but liver and renal damage were observed in tail vein administration to mice.Our findings suggest that there are the safety of the nanomaterial contained in food and also the necessity of inquiring.
  • Examination of nano-particles in mice with drugs or chemicals induced toxicity.
    Grant-in-Aid for Young Scientists (B)
    Teikyo Heisei University
    2009 - 2010
    Nanomaterials are used frequently in microelectronics, cosmetics and sunscreen, and research for the development of nanomaterial-based drug delivery systems is promising. Interactions between nano-size materials and drugs that have therapeutic potential need investigating. Here, we investigated whether nano-size materials affect drugs-induced toxicity using inert polystyrene particles, nano-silicaand fullerrene particles, which have been widely used in industrial materials, carbon tertrachloride, a popular anti-tumor agent, cisplatin, and a widely used herbicide, paraquat. The result, inert polystyrene particles and nano-silica particles induced liver injury by using together with the drugs. Our findings suggest that further evaluation on the interaction between nano-size materials and drugs is critical for the pharmaceutical application of nanotechnology.
  • ウイルスベクターを用いたC型肝炎ウイルス感染評価系の開発
    2008 - 2008

Industrial Property Rights

■Achievement List

Lectures, oral presentations, etc.

  • Influence of nanoclay particles on hepatotoxicity and drug interaction toxicity in mice.
    Katsuhiro Isoda, 53th-Congress of the European Societies of Toxicology, 11 Sep. 2017, 11 Sep. 2017 - 13 Sep. 2017, Not exist, English, Slovakia, International conferences, Not International Collabolation, Verbal presentations (general), the European Societies of Toxicology, ,Bratislava,
    Url, Nanoclay is a general term for layered mineral silicate nanoparticles that are ideally suited for use in clay-based nanocomposites.  The potential biological hazards of nanoclays have not been addressed, however. Therefore, we investigated the in vivo effects and drug interactions of nanoclays.   Our findings thus indicate that nanoclay particles are potentially hepato- and nephrotoxic.
  • 14 May 2014, 14 May 2014 - 14 May 2014, Exist, Japanese, Japan, Domestic conferences, Not International Collabolation, Verbal presentations (invitation, special)
    Url
  • Acute hepatotoxicity, nephrotoxicity, and drug/chemical interaction toxicity of platinum nanoparticles in mice
    Katsuhiro Isoda, 27 Aug. 2016, 27 Aug. 2016 - 29 Aug. 2016, Not exist, International conferences, Verbal presentations (general)
    Url

■University education and qualification information

Qualifications, licenses

  • 01 Aug. 1999