Dai Nakae
| Faculty of Health Care and Medical Sports,Department of Medical Sports,Animal Medical Course | Professor |
Last Updated :2025/06/19
■Researcher basic information
Research Keyword
- food factor
- toxicologic pathology
- Preventive Medicine
- Animal Preventive Medicine
- safety asessment
- risk analysis
- preneoplastic lesion
- gene mutation
- oxidative stress
- choine-deficient, methionine-lowered, L-amino acid-defined diet
- epigenetic carcinogenesis
- species difference
- gpt delta transgenic animal
- endogenous carcinogenesis
- 8-oxoguanine
- heterocyclicamine
- nitroso compound
- environmental carcinogen
- genetically modified animal
- diethylnitrosamine
- chemical caricnogenesis
- environmental factor
- carcinogen
- toxicology
Field Of Study
- Other, Other, risk assessment of chemicals
- Other, Other, preventive medicine for animals and humans
- Other, Other, toxicology/toxicologic pathology
- Life sciences, Hygiene and public health (non-laboratory), public health
- Life sciences, Nutrition and health science, nutritional and health science
- Life sciences, Experimental pathology, experimental pathology
■Career
Career
- Apr. 2022 - Present
Teikyo Heisei University, Animal Medical Course, Department of Medical Sports, Faculty of Health Care and Medical Sports, Professor, M.D., D.M.Sc. - Apr. 2015 - Mar. 2022
Tokyo University of Agriculture, Laboratory of Food Safety Assessment Science, Department of Nutritional Science and Food Safety, Faculty of Applied Biosciences, Professor, M.D., D.M.Sc.
■Research activity information
Award
Paper
- Aims of the Society of Preventive Medicine for Animals and Humans: Proceedings of the first annual meeting commemorating the establishment of the society
Dai Nakae
Foods and Food Ingredients Journal of Japan, Apr. 2025, [Invited]
Lead, Corresponding - New approaches for quality of life improvement of both animals and humans
Dai Nakae
Foods and Food Ingredients Journal of Japan, Apr. 2025, [Invited]
Lead, Corresponding - Drug review process advancement and required manufacturer and contract research oraganization responses.
Takayuki Anzai; Glenn J Myatt; Frances Hall; Brenda Finney; Kenshi Nakagawa; Hijiri Iwata; Reo Anzai; Anne Dickinson; Matthew Freer; Dai Nakae; Hiroshi Onodera; Takaaki Matsuyama
Journal of toxicologic pathology, Apr. 2024 - Urinary liver‐type fatty acid binding protein is a biomarker reflecting renal damage and the ameliorative effect of drugs at an early stage of histone‐induced
acute kidney injury
Keiichi Ohata; Takeshi Sugaya; Hanh Nhung Nguyen; Karin Arai; Yuri Hatanaka; Kinuko Uno; Marika Tohma; Teppei Uechi; Keita Sekiguchi; Tsuyoshi Oikawa; Hiroshi Nagabukuro; Kanako Kuniyeda; Atsuko Kamijo‐Ikemori; Noriko Suzuki‐Kemuriyama; Dai Nakae; Eisei Noiri; Katsuhiro Miyajima
Nephrology, 11 Nov. 2023 - Time-Course of Transcriptomic Change in the Lungs of F344 Rats Repeatedly Exposed to a Multiwalled Carbon Nanotube in a 2-Year Test.
Motoki Hojo; Ai Maeno; Yoshimitsu Sakamoto; Yukio Yamamoto; Yuhji Taquahashi; Akihiko Hirose; Jin Suzuki; Akiko Inomata; Dai Nakae
Nanomaterials (Basel, Switzerland), 19 Jul. 2023 - Urinary liver-type fatty acid binding protein is increased in the early stages of the disease with a risk of acute kidney injury induced by histone.
Keiichi Ohata; Takeshi Sugaya; Hanh Nhung Nguyen; Yuri Hatanaka; Kinuko Uno; Marika Tohma; Tsuyoshi Oikawa; Hiroshi Nagabukuro; Kanako Kuniyeda; Atsuko Kamijo-Ikemori; Noriko Suzuki-Kemuriyama; Dai Nakae; Eisei Noiri; Katsuhiro Miyajima
Nephrology (Carlton, Vic.), Jun. 2023 - Nonalcoholic steatohepatitis-associated hepatocarcinogenesis in mice fed a modified choline-deficient, methionine-lowered, L-amino acid-defined diet and the role of signal changes.
Noriko Suzuki-Kemuriyama; Akari Abe; Sae Nakane; Megumi Yuki; Katsuhiro Miyajima; Dai Nakae
PloS one, 2023 - Continuous infiltration of small peritoneal macrophages in the mouse peritoneum through CCR2-dependent and -independent routes during fibrosis and mesothelioma development induced by a multiwalled carbon nanotube, MWNT-7.
Motomu Shimizu; Motoki Hojo; Kiyomi Ikushima; Yukio Yamamoto; Ai Maeno; Yoshimitsu Sakamoto; Naozumi Ishimaru; Yuhji Taquahashi; Jun Kanno; Akihiko Hirose; Jin Suzuki; Akiko Inomata; Dai Nakae
The Journal of toxicological sciences, 2023 - Effects of Siraitia grosvenorii extract on nonalcoholic steatohepatitis-like lesions in Sprague Dawley rats fed a choline-deficient, methionine-lowered, l-amino acid-defined diet
Kinuko Uno; Katsuhiro Miyajima; Shuji Ogawa; Noriko Suzuki-Kemuriyama; Dai Nakae
Journal of Toxicologic Pathology, 2023 - Effects of Siraitia grosvenorii extract on nonalcoholic steatohepatitis-like lesions in Sprague Dawley rats fed a choline-deficient, methionine-lowered, l-amino acid-defined diet
Kinuko Uno; Katsuhiro Miyajima; Shuji Ogawa; Noriko Suzuki-Kemuriyama; Dai Nakae
JOURNAL OF TOXICOLOGIC PATHOLOGY, 2023 - Effects of Siraitia grosvenorii extract on nonalcoholic steatohepatitis-like lesions in Sprague Dawley rats fed a choline-deficient, methionine-lowered, l-amino acid-defined diet.
Kinuko Uno; Katsuhiro Miyajima; Shuji Ogawa; Noriko Suzuki-Kemuriyama; Dai Nakae
Journal of toxicologic pathology, Jan. 2023 - Correction to: A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a cholinedeficient, methionine-lowered, L-amino acid-defined, high-fat diet. (Lipids in Health and Disease, (2020), 19, 1, (251), 10.1186/s12944-020-01423-3)
Noriko Suzuki-Kemuriyama; Akari Abe; Kinuko Uno; Shuji Ogawa; Atsushi Watanabe; Ryuhei Sano; Megumi Yuki; Katsuhiro Miyajima; Dai Nakae
Lipids in Health and Disease, Dec. 2022 - Two-year intermittent exposure of a multiwalled carbon nanotube by intratracheal instillation induces lung tumors and pleural mesotheliomas in F344 rats
Motoki Hojo; Ai Maeno; Yoshimitsu Sakamoto; Aya Ohnuki; Yukie Tada; Yukio Yamamoto; Kiyomi Ikushima; Ryota Inaba; Jin Suzuki; Yuhji Taquahashi; Satoshi Yokota; Norihiro Kobayashi; Makoto Ohnishi; Yuko Goto; Takamasa Numano; Hiroyuki Tsuda; David B. Alexander; Jun Kanno; Akihiko Hirose; Akiko Inomata; Dai Nakae
Particle and Fibre Toxicology, Dec. 2022 - CD44 expression in the bile duct epithelium is related to hepatic fibrosis in nonalcoholic steatohepatitis rats induced by a choline-deficient, methionine-lowered, L-amino acid diet.
Kinuko Uno; Katsuhiro Miyajima; Marika Toma; Noriko Suzuki-Kemuriyama; Dai Nakae
Journal of toxicologic pathology, Apr. 2022 - Iron oxide nanoparticles exert inhibitory effects on N-Bis(2-hydroxypropyl)nitrosamine (DHPN)-induced lung tumorigenesis in rats.
Yukie Tada; Motoki Hojo; Katsuhiro Yuzawa; Akemichi Nagasawa; Jin Suzuki; Akiko Inomata; Takako Moriyasu; Dai Nakae
Regulatory toxicology and pharmacology : RTP, Feb. 2022 - Correction to: A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a cholinedeficient, methionine-lowered, L-amino acid-defined, high-fat diet.
Noriko Suzuki-Kemuriyama; Akari Abe; Kinuko Uno; Shuji Ogawa; Atsushi Watanabe; Ryuhei Sano; Megumi Yuki; Katsuhiro Miyajima; Dai Nakae
Lipids in health and disease, 07 Jan. 2022 - CD44 expression in the bile duct epithelium is related to hepatic fibrosis in nonalcoholic steatohepatitis rats induced by a choline-deficient, methionine-lowered, L-amino acid diet
Kinuko Uno; Katsuhiro Miyajima; Marika Toma; Noriko Suzuki Kemuriyama; Dai Nakae
Journal of Toxicologic Pathology, 2022 - CD44 expression in the bile duct epithelium is related to hepatic fibrosis in nonalcoholic steatohepatitis rats induced by a choline-deficient, methionine-lowered, L-amino acid diet
Kinuko Uno; Katsuhiro Miyajima; Marika Toma; Noriko Suzuki-Kemuriyama; Dai Nakae
JOURNAL OF TOXICOLOGIC PATHOLOGY, 2022 - Nonobese mice with nonalcoholic steatohepatitis fed on a choline-deficient, l-amino acid-defined, high-fat diet exhibit alterations in signaling pathways
Noriko Suzuki-Kemuriyama; Akari Abe; Sae Nakane; Kinuko Uno; Shuji Ogawa; Atsushi Watanabe; Ryuhei Sano; Megumi Yuki; Katsuhiro Miyajima; Dai Nakae
FEBS Open Bio, Nov. 2021 - Nonobese mice with nonalcoholic steatohepatitis fed on a choline-deficient, l-amino acid-defined, high-fat diet exhibit alterations in signaling pathways
Noriko Suzuki-Kemuriyama; Akari Abe; Sae Nakane; Kinuko Uno; Shuji Ogawa; Atsushi Watanabe; Ryuhei Sano; Megumi Yuki; Katsuhiro Miyajima; Dai Nakae
FEBS OPEN BIO, Nov. 2021 - Nonobese mice with nonalcoholic steatohepatitis fed on a choline-deficient, l-amino acid-defined, high-fat diet exhibit alterations in signaling pathways.
Noriko Suzuki-Kemuriyama; Akari Abe; Sae Nakane; Kinuko Uno; Shuji Ogawa; Atsushi Watanabe; Ryuhei Sano; Megumi Yuki; Katsuhiro Miyajima; Dai Nakae
FEBS open bio, Nov. 2021 - A case of spontaneous zymbal’s gland carcinoma with lung metastasis in an aged fischer 344 rat
Ai Maeno; Yoshimitsu Sakamoto; Motoki Hojo; Yukie Tada; Jin Suzuki; Akiko Inomata; Takako Moriyasu; Akihiko Hirose; Noriko Kemuriyama; Katsuhiro Miyajima; Dai Nakae
Journal of Toxicologic Pathology, 01 Oct. 2021 - Histological sequence of the development of rat mesothelioma by MWCNT, with the involvement of apolipoproteins.
Motoki Hojo; Yukio Yamamoto; Yoshimitsu Sakamoto; Ai Maeno; Aya Ohnuki; Jin Suzuki; Akiko Inomata; Takako Moriyasu; Yuhji Taquahashi; Jun Kanno; Akihiko Hirose; Dai Nakae
Cancer science, 04 Mar. 2021 - Glomerular Hyperfiltration With Hyperglycemia in the Spontaneously Diabetic Torii (SDT) Fatty Rat, an Obese Type 2 Diabetic Model
Ryuhei Sano; Yukihito Ishii; Masao Yamanaka; Yuzo Yasui; Yusuke Kemmochi; Fuko Kuroki; Miki Sugimoto; Sumiaki Fukuda; Tomohiko Sasase; Katsuhiro Miyajima; Dai Nakae; Takeshi Ohta
Physiological Research, Feb. 2021 - Effects of excessive sodium chloride loading in the spontaneously diabetic torii (Sdt) fatty rats, a preclinical model of type 2 diabetes mellitus
Soon Hui Teoh; Katsuhiro Miyajima; Yuichi Shinozaki; Masami Shinohara; Keiichi Ohata; François Briand; Rika Morimoto; Yuka Nakamura; Kinuko Uno; Noriko Kemuriyama; Dai Nakae; Takeshi Ohta; Tatsuya Maekawa
Journal of Toxicological Sciences, 2021 - Effects of excessive sodium chloride loading in the spontaneously diabetic torii (SDT) fatty rats, a preclinical model of type 2 diabetes mellitus
Soon Hui Teoh; Katsuhiro Miyajima; Yuichi Shinozaki; Masami Shinohara; Keiichi Ohata; Francois Briand; Rika Morimoto; Yuka Nakamura; Kinuko Uno; Noriko Kemuriyama; Dai Nakae; Takeshi Ohta; Tatsuya Maekawa
JOURNAL OF TOXICOLOGICAL SCIENCES, 2021 - Effects of excessive sodium chloride loading in the spontaneously diabetic torii (SDT) fatty rats, a preclinical model of type 2 diabetes mellitus.
Soon Hui Teoh; Katsuhiro Miyajima; Yuichi Shinozaki; Masami Shinohara; Keiichi Ohata; François Briand; Rika Morimoto; Yuka Nakamura; Kinuko Uno; Noriko Kemuriyama; Dai Nakae; Takeshi Ohta; Tatsuya Maekawa
The Journal of toxicological sciences, 2021 - A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a choline-deficient, methionine-lowered, L-amino acid-defined, high-fat diet.
Noriko Suzuki-Kemuriyama; Akari Abe; Kinuko Uno; Shuji Ogawa; Atsushi Watanabe; Ryuhei Sano; Megumi Yuki; Katsuhiro Miyajima; Dai Nakae
Lipids in health and disease, 14 Dec. 2020 - A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a choline-deficient, methionine-lowered, L-amino acid-defined, high-fat diet
Noriko Suzuki-Kemuriyama; Akari Abe; Kiniko Uno; Shuji Ogawa; Atsushi Watanabe; Ryuhei Sano; Megumi Yuki; Katsuhiro Miyajima; Dai Nakae
Lipids in Health and Disease, Dec. 2020 - A Trans Fatty Acid Substitute Aggravates Nonalcoholic Steatohepatitis Induced in Mice by Feeding a Choline-Deficient, Methionine-Lowered, L-Amino Acid-Defined, High-Fat Diet
Noriko Suzuki-Kemuriyama; Akari Abe; Kinuko Uno; Shuji Ogawa; Atsushi Watanabe; Ryuhei Sano; Megumi Yuki; Katsuhiro Miyajima; Dai Nakae
21 Sep. 2020 - Identification of descarbonsildenafil in an adulterated dietary supplement and evaluation of its inhibitory activity for phosphodiesterase type 5 (PDE5)
Yoko Ichikawa-Kaji; Junichi Nakajima; Shoko Kikkawa; Fujio Ishizawa; Rei Nishiyama; Kiyoko Kishimoto; Nozomi Uemura; Miki Satoh; Jin Suzuki; Akiko Inomata; Dai Nakae; Isao Azumaya; Katsuya Honda; Takako Moriyasu
Journal of the Food Hygienic Society of Japan, Feb. 2020 - Impact of altered dietary calcium–phosphorus ratio caused by high-phosphorus diets in a rat chronic kidney disease (CKD) model created by partial ligation of the renal arteries
Atsushi Watanabe; Toshinori Koizumi; Takumi Horikawa; Yusuke Sano; Haruka Uki; Katsuhiro Miyajima; Noriko Kemuriyama; Reo Anzai; Hijiri Iwata; Takayuki Anzai; Kenshi Nakagawa; Dai Nakae
Journal of Toxicologic Pathology, 2020 - A histopathological analysis of spontaneous neoplastic and non-neoplastic lesions in aged male RccHan:WIST rats
Motoki Hojo; Yoshimitsu Sakamoto; Ai Maeno; Kuniaki Tayama; Yukie Tada; Katsuhiro Yuzawa; Hiroshi Ando; Yoshikazu Kubo; Akemichi Nagasawa; Kazuyoshi Tanaka; Norio Yano; Fujifumi Kaihoko; Yuko Hasegawa; Toshinari Suzuki; Akiko Inomata; Takako Moriyasu; Katsuhiro Miyajima; Dai Nakae
Journal of Toxicologic Pathology, 2020 - Establishment of the Global SEND Alliance (G-SEND) in Japan and efficient creation of electronic SEND datasets between CROs.
Takayuki Anzai; Takaaki Matsuyama; Michael Wasko; Hirofumi Hatakeyama; Shin-Ichi Horikawa; Reo Anzai; Hijiri Iwata; Norio Imai; Fukutaro Mizuhashi; Masaru Tsuboi; Takeshi Okuzono; Hisayoshi Takagi; Hyeon Cho; Bryan Tan Siang Rong; Fumio Masaki; Dai Nakae
Journal of toxicologic pathology, Apr. 2019 - Hepatic lesions induced by feeding Western diets to Zucker fatty rats, an insulin-resistant model.
Tomoyuki Saito; Yasufumi Toriniwa; Yukihito Ishii; Atsuhiro Uemura; Katsuhiro Miyajima; Kinuko Uno; Yuki Shirai; Dai Nakae; Takeshi Ohta
Journal of toxicologic pathology, Oct. 2018 - Establishment of an in vivo simulating co-culture assay platform for genotoxicity of multi-walled carbon nanotubes
Emi Fukai; Haruna Sato; Masatoshi Watanabe; Dai Nakae; Yukari Totsuka
Cancer Science, 01 Apr. 2018, [Reviewed] - Comparative study for carcinogenicity of 7 different multi-wall carbon nanotubes with different physicochemical characteristics by a single intraperitoneal injection in male Fischer 344 rats
Yoshimitsu Sakamoto; Motoki Hojo; Yuki Kosugi; Kimiyo Watanabe; Akihiko Hirose; Akiko Inomata; Toshinari Suzuki; Dai Nakae
Journal of Toxicological Sciences, 2018 - Effect of dosing frequency of teriparatide (PTH 1-34) on bone formation in rats: Comparison of bone metabolism marker levels
Atsushi Watanabe; Kazuyuki Tsurui; Shigeki Yoneyama; Hijiri Iwata; Takayuki Anzai; Christopher Jerome; Dai Nakae
Journal of Toxicological Sciences, 2018 - Hepatic lesions induced by feeding western diets to Zucker fatty rats, an insulin-resistant model
Tomoyuki Saito; Yasufumi Toriniwa; Yukihito Ishii; Atsuhiro Uemura; Katsuhiro Miyajima; Kinuko Uno; Yuki Shirai; Dai Nakae; Takeshi Ohta
Journal of Toxicologic Pathology, 2018 - Hepatic lesions induced by feeding Western diets to Zucker fatty rats, an insulin-resistant model
Tomoyuki Saito; Yasufumi Toriniwa; Yukihito Ishii; Atsuhiro Uemura; Katsuhiro Miyajima; Kinuko Uno; Yuki Shirai; Dai Nakae; Takeshi Ohta
JOURNAL OF TOXICOLOGIC PATHOLOGY, 2018 - Absence of in vivo mutagenicity of multiwalled carbon nanotubes in single intratracheal instillation study using F344 gpt delta rats
Katsuyoshi Horibata; Akiko Ukai; Akio Ogata; Dai Nakae; Hiroshi Ando; Yoshikazu Kubo; Akemichi Nagasawa; Katsuhiro Yuzawa; Masamitsu Honma
Genes and Environment, 2017, [Reviewed] - Specific pathologist responses for standard for exchange of nonclinical data (SEND)
Atsushi Watanabe; Osamu Kusuoka; Norihiro Sato; Osamu Nakazono; Michael Wasko; Daniel Potenta; Dai Nakae; Hirofumi Hatakeyama; Hijiri Iwata; Misaki Naota; Takayuki Anzai
Journal of Toxicologic Pathology, 2017, [Reviewed] - Extracts of black and brown rice powders improve hepatic lipid accumulation via the activation of PPAR alpha in obese and diabetic model mice
Angelina D. R. Felix; Nobuyuki Takahashi; Mami Takahashi; Rie Katsumata-Tsuboi; Ryo Satoh; Teoh Soon Hui; Katsuhiro Miyajima; Dai Nakae; Hirofumi Inoue; Mariko Uehara
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2017, [Reviewed] - Identification of (1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone (DP-UR-144) in a herbal drug product that was commercially available in the Tokyo metropolitan area
Yoko Ichikawa; Jun'ichi Nakajima; Misako Takahashi; Nozomi Uemura; Masao Yoshida; Atsuko Suzuki; Jin Suzuki; Dai Nakae; Takako Moriyasu; Mitsugu Hosaka
FORENSIC TOXICOLOGY, Jan. 2017, [Reviewed] - Effects Induced by Organic Acids in a Human Lung Alveolar Carcinoma Cell Line A549
Tomoko Okubo; Toshinari Suzuki; Mitsugu Hosaka; Dai Nakae
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Oct. 2016, [Reviewed] - Different effects of eicosapentaenoic and docosahexaenoic acids on atherogenic high- fat diet-induced non-alcoholic fatty liver disease in mice
Suzuki-Kemuriyama Noriko; Takashi Matsuzaka; Motoko Kuba; Hiroshi Ohno; Songiee Han; Yoshinori Takeuchi; Masaaki Isaka; Kazuto Kobayashi; Hitoshi Iwasaki; Shigeru Yatoh; Hiroaki Suzuki; Katsuhiro Miyajima; Dai Nakae; Naoya Yahagi; Yoshimi Nakagawa; Hirohito Sone; Nobuhiro Yamada; Hitoshi Shimano
PLoS ONE, 01 Jun. 2016, [Reviewed] - Time course of carcinogenesis by MWCNT in rats
HOJO Motoki; SAKAMOTO Yoshimitsu; FUJITANI Tomoko; YAMAMOTO Yukio; HASEGAWA Yuko; TADA Yukie; KUBO Yoshikazu; NAGASAWA Akemichi; KAIHOKO Fujifumi; TAKAHASHI Hiroshi; YUZAWA Katsuhiro; ANDO Hiroshi; TANAKA Kazuyoshi; HIROSE Akihiko; INOMATA Akiko; NAKAE Dai
Annual Meeting of the Japanese Society of Toxicology, 2016 - Comparative effects of sulfhydryl compounds on target organellae, nuclei and mitochondria, of hydroxylated fullerene-induced cytotoxicity in isolated rat hepatocytes
Yoshio Nakagawa; Akiko Inomata; Akio Ogata; Dai Nakae
JOURNAL OF APPLIED TOXICOLOGY, Dec. 2015, [Reviewed] - Expression of MAS1 in breast cancer.
Yi Luo; Eriko Tanabe; Misaho Kitayoshi; Yukiko Nishiguchi; Rina Fujiwara; Sayako Matsushima; Takamitsu Sasaki; Tomonori Sasahira; Yoshitomo Chihara; Dai Nakae; Kiyomu Fujii; Hitoshi Ohmori; Hiroki Kuniyasu
Cancer science, Sep. 2015 - Chemokine (C‐C motif) ligand 3 detection in the serum of persons exposed to asbestos: A patient‐based study
Jiegou Xu; David B. Alexander; Masaaki Iigo; Hirokazu Hamano; Satoru Takahashi; Takako Yokoyama; Munehiro Kato; Ikuji Usami; Takeshi Tokuyama; Masahiro Tsutsumi; Mouka Tamura; Tetsuya Oguri; Akio Niimi; Yoshimitsu Hayashi; Yoshifumi Yokoyama; Ken Tonegawa; Katsumi Fukamachi; Mitsuru Futakuchi; Yuto Sakai; Masumi Suzui; Michihiro Kamijima; Naomi Hisanaga; Toyonori Omori; Dai Nakae; Akihiko Hirose; Jun Kanno; Hiroyuki Tsuda
Cancer Science, Jul. 2015, [Reviewed] - In vitro effects induced by diesel exhaust at an air-liquid interface in a human lung alveolar carcinoma cell line A549
Tomoko Okubo; Mitsugu Hosaka; Dai Nakae
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, Jul. 2015, [Reviewed] - Chemokine (C-C motif) ligand 3 detection in the serum of persons exposed to asbestos: A patient-based study
Jiegou Xu; David B. Alexander; Masaaki Iigo; Hirokazu Hamano; Satoru Takahashi; Takako Yokoyama; Munehiro Kato; Ikuji Usami; Takeshi Tokuyama; Masahiro Tsutsumi; Mouka Tamura; Tetsuya Oguri; Akio Niimi; Yoshimitsu Hayashi; Yoshifumi Yokoyama; Ken Tonegawa; Katsumi Fukamachi; Mitsuru Futakuchi; Yuto Sakai; Masumi Suzui; Michihiro Kamijima; Naomi Hisanaga; Toyonori Omori; Dai Nakae; Akihiko Hirose; Jun Kanno; Hiroyuki Tsuda
Cancer Science, 01 Jul. 2015, [Reviewed] - Effects of phenyl N-tert-butyl nitrone (PBN) on induction of mesothelial and pulmonary proliferative lesions by multi-wall carbon nanotube (CNT) in rats
SAKAMOTO Yoshimitsu; OGATA Akio; HOJO Motoki; YUZAWA Katsuhiro; ANDO Hiroshi; KUBO Yoshikazu; NAGASAWA Akemichi; TAKAHASHI Hiroshi; HIROSE Akihiko; INOUE Yoshiyuki; HASHIZUME Naoki; INOMATA Akiko; NAKAE Dai
Annual Meeting of the Japanese Society of Toxicology, 2015 - Spontaneous neoplastic and non-neoplastic lesions in aging male RccHan:WIST rats
HOJO Motoki; SAKAMOTO Yoshimitsu; TADA Yukie; OGATA Akio; YUZAWA Katsuhiro; ANDO Hiroshi; KUBO Yoshikazu; NAGASAWA Akemichi; KAIHOKO Fujifumi; TAKAHASHI Hiroshi; YANO Norio; INOMATA Akiko; NAKAE Dai
Annual Meeting of the Japanese Society of Toxicology, 2015 - Coparison of fetal toxicity of various multi-wall carbon nanotubes in mice
FUJITANI Tomoko; INOMATA Akiko; OGATA Akio; ANDO Hiroshi; KUBO Yoshikazu; NAKAE Dai; HIROSE Akihiko; NISHIMURA Tetsuji; IKEDA Reiko
Annual Meeting of the Japanese Society of Toxicology, 2015 - Effects of maternal piperonyl butoxide exposure on behavioral development in F1-generation mice
TANAKA Toyohito; OGATA Akio; INOMATA Akiko; NAKAE Dai
Annual Meeting of the Japanese Society of Toxicology, 2015 - Comparison of fetal toxicity of various multi-wall carbon nanotubes in mice
Tomoko Fujitani; Akiko Inomata; Akio Ogata; Yoshimitsu Sakamoto; Akihiko Hirose; Tetsuji Nishimura; Reiko Ikeda; Dai Nakae
Toxicology Reports, 2015, [Reviewed] - Identification of N,N-bis(1-pentylindol-3-yl-carboxy)naphthylamine (BiPICANA) found in an herbal blend product in the Tokyo metropolitan area and its cannabimimetic effects evaluated by in vitro [35S]GTPγS binding assays
Jun’ichi Nakajima; Misako Takahashi; Nozomi Uemura; Takako Seto; Haruhiko Fukaya; Jin Suzuki; Masao Yoshida; Maiko Kusano; Hiroshi Nakayama; Kei Zaitsu; Akira Ishii; Takako Moriyasu; Dai Nakae
Forensic Toxicology, 2015, [Reviewed] - OCCURRENCE AND BEHAVIOR OF THE CHIRAL ANTI-INFLAMMATORY DRUG NAPROXEN IN AN AQUATIC ENVIRONMENT
Toshinari Suzuki; Yuki Kosugi; Mitsugu Hosaka; Tetsuji Nishimura; Dai Nakae
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, Dec. 2014, [Reviewed] - Rapid identification of a narcotic plant Papaver bracteatum using flow cytometry
Masako Aragane; Daisuke Watanabe; Jun'ichi Nakajima; Masao Yoshida; Masao Yoshizawa; Tomohiro Abe; Rei Nishiyama; Jin Suzuki; Takako Moriyasu; Dai Nakae; Hiroshi Sudo; Hiroyuki Sato; Atuyuki Hishida; Nobuo Kawahara; So Makabe; Ikuo Nakamura; Masahiro Mii
JOURNAL OF NATURAL MEDICINES, Oct. 2014, [Reviewed] - Effects of Different Types of Bedding Materials on Behavioral Development in Laboratory CD1 Mice (Mus musculus)
Toyohito Tanaka; Akio Ogata; Akiko Inomata; Dai Nakae
BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY, Oct. 2014, [Reviewed] - High-temperature calcined fullerene nanowhiskers as well as long needle-like multi-wall carbon nanotubes have abilities to induce NLRP3-mediated IL-1 beta secretion
Hongyan Cui; Weijia Wu; Keiichiro Okuhira; Kun'ichi Miyazawa; Takayuki Hattori; Kimie Sai; Mikihiko Naito; Kazuhiro Suzuki; Tetsuji Nishimura; Yoshimitsu Sakamoto; Akio Ogata; Tomokazu Maeno; Akiko Inomata; Dai Nakae; Akihiko Hirose; Tomoko Nishimaki-Mogami
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2014, [Reviewed] - Teratogenicity of asbestos in mice
Tomoko Fujitani; Motoki Hojo; Akiko Inomata; Akio Ogata; Akihiko Hirose; Tetsuji Nishimura; Dai Nakae
JOURNAL OF TOXICOLOGICAL SCIENCES, Apr. 2014, [Reviewed] - Magnetite Nanoparticles Induce Genotoxicity in the Lungs of Mice via Inflammatory Response.
Totsuka Y; Ishino K; Kato T; Goto S; Tada Y; Nakae D; Watanabe M; Wakabayashi K
Nanomaterials (Basel, Switzerland), Mar. 2014, [Reviewed] - Multi-step lung carcinogenesis model induced by oral administration of N-nitrosobis(2-hydroxypropyl)amine in rats
Toshifumi Tsujiuchi; Dai Nakae; Yoichi Konishi
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, Mar. 2014, [Reviewed] - Effects of different bedding materials on behavioral development in F1-generation mice
TANAKA Toyohito; OGATA Akio; INOMATA Akiko; NAKAE Dai
Annual Meeting of the Japanese Society of Toxicology, 2014 - Pancreatic ductal adenocarcinoma in a Wistar Hannover GALAS rat
Yusuke Kuroda; Seigo Hayashi; Soichiro Hagio; Masayoshi Abe; Satoshi Furukawa; Dai Nakae
Journal of Toxicologic Pathology, 2014, [Reviewed] - Identification of a synthetic cannabinoid A-836339 as a novel compound found in a product
Nozomi Uemura; Haruhiko Fukaya; Chieko Kanai; Masao Yoshida; Jun'ichi Nakajima; Misako Takahashi; Jin Suzuki; Takako Moriyasu; Dai Nakae
FORENSIC TOXICOLOGY, Jan. 2014, [Reviewed] - Effects of N-acetyl-l-cysteine on target sites of hydroxylated fullerene-induced cytotoxicity in isolated rat hepatocytes
Yoshio Nakagawa; Toshinari Suzuki; Kazuo Nakajima; Akiko Inomata; Akio Ogata; Dai Nakae
ARCHIVES OF TOXICOLOGY, Jan. 2014, [Reviewed] - Structure-dependent inhibitory effects of synthetic cannabinoids against 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and skin tumour promotion in mice
Jun'ichi Nakajima; Dai Nakae; Ken Yasukawa
JOURNAL OF PHARMACY AND PHARMACOLOGY, Aug. 2013, [Reviewed] - Effects of Maternal Exposure to Imazalil on Behavioral Development in F-1-Generation Mice
Toyohito Tanaka; Akio Ogata; Akiko Inomata; Dai Nakae
BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY, Aug. 2013, [Reviewed] - Genotoxicity of multi-walled carbon nanotubes in both in vitro and in vivo assay systems
Tatsuya Kato; Yukari Totsuka; Kousuke Ishino; Yoko Matsumoto; Yukie Tada; Dai Nakae; Sumio Goto; Shuichi Masuda; Sayaka Ogo; Masanobu Kawanishi; Takashi Yagi; Tomonari Matsuda; Masatoshi Watanabe; Keiji Wakabayashi
NANOTOXICOLOGY, Jun. 2013, [Reviewed] - Effects of maternal imazalil exposure on behavioral development in F1-generation mice
TANAKA Toyohito; INOMATA Akiko; OGATA Akio; NAKAE Dai
Annual Meeting of the Japanese Society of Toxicology, 2013 - Long-term pulmonary responses to quadweekly intermittent intratracheal spray instillations of magnetite (Fe3O4) nanoparticles for 52 weeks in fischer 344 rats
Yukie Tada; Norio Yano; Hiroshi Takahashi; Katsuhiro Yuzawa; Hiroshi Ando; Yoshikazu Kubo; Akemichi Nagasawa; Akiko Inomata; Akio Ogata; Dai Nakae
Journal of Toxicologic Pathology, 2013, [Reviewed] - Multi-walled carbon nanotubes translocate into the pleural cavity and induce visceral mesothelial proliferation in rats
Jiegou Xu; Mitsuru Futakuchi; Hideo Shimizu; David B. Alexander; Kazuyoshi Yanagihara; Katsumi Fukamachi; Masumi Suzui; Jun Kanno; Akihiko Hirose; Akio Ogata; Yoshimitsu Sakamoto; Dai Nakae; Toyonori Omori; Hiroyuki Tsuda
CANCER SCIENCE, Dec. 2012, [Reviewed] - Multi-walled carbon nanotubes translocate into the pleural cavity and induce visceral mesothelial proliferation in rats
Jiegou Xu; Mitsuru Futakuchi; Hideo Shimizu; David B. Alexander; Kazuyoshi Yanagihara; Katsumi Fukamachi; Masumi Suzui; Jun Kanno; Akihiko Hirose; Akio Ogata; Yoshimitsu Sakamoto; Dai Nakae; Toyonori Omori; Hiroyuki Tsuda
Cancer Science, Dec. 2012, [Reviewed] - Reproductive and Neurobehavioral Effects of Brilliant Blue FCF in Mice
Toyohito Tanaka; Osamu Takahashi; Akiko Inomata; Akio Ogata; Dai Nakae
BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY, Dec. 2012, [Reviewed] - Teratogenicity of multi-wall carbon nanotube (MWCNT) in ICR mice
Tomoko Fujitani; Ken-ichi Ohyama; Akihiko Hirose; Tetsuji Nishimura; Dai Nakae; Akio Ogata
JOURNAL OF TOXICOLOGICAL SCIENCES, Feb. 2012, [Reviewed] - Effects of sustained stimulation with multi-wall carbon nanotubes on immune and inflammatory responses in mice
Atsumi Yamaguchi; Tomoko Fujitani; Ken-ichi Ohyama; Dai Nakae; Akihiko Hirose; Tetsuji Nishimura; Akio Ogata
JOURNAL OF TOXICOLOGICAL SCIENCES, Feb. 2012, [Reviewed] - Induction of mesothelioma by an intraperitoneal administration of 5 different
SAKAMOTO Yoshimitsu; OGATA Akio; MAENO Tomokazu; NISHIMURA Tetsuji; HIROSE Akihiko; KOSUGI Yuki; SUZUKI Tosinari; NAKAE Dai
Annual Meeting of the Japanese Society of Toxicology, 2012 - Teratogenicity of multi-wall carbon nanotube in ICR mice
FUJITANI Tomoko; OHYAMA Ken-ichi; HIROSE Akihiko; NISHIMURA Tetsuji; NAKAE Dai; OGATA Akio
Annual Meeting of the Japanese Society of Toxicology, 2012 - Carcinogen-induced thyroid proliferative lesions in Wistar Hannover GALAS rats with thyroid dysplasia
Masayoshi Abe; Seigo Hayashi; Koji Usuda; Soichiro Hagio; Satoshi Furukawa; Dai Nakae
Journal of Toxicologic Pathology, 2012, [Reviewed] - Acute phase pulmonary responses to a single intratracheal spray instillation of magnetite (Fe3O4) nanoparticles in fischer 344 rats
Yukie Tada; Norio Yano; Hiroshi Takahashi; Katsuhiro Yuzawa; Hiroshi Ando; Yoshikazu Kubo; Akemichi Nagasawa; Akio Ogata; Dai Nakae
Journal of Toxicologic Pathology, 2012, [Reviewed] - Cytotoxic effects of hydroxylated fullerenes on isolated rat hepatocytes via mitochondrial dysfunction
Yoshio Nakagawa; Toshinari Suzuki; Hidemi Ishii; Dai Nakae; Akio Ogata
ARCHIVES OF TOXICOLOGY, Nov. 2011, [Reviewed] - Lack of chronic toxicity and carcinogenicity of dietary administrated catechin mixture in Wistar Hannover GALAS rats
Midori Yoshida; Miwa Takahashi; Kaoru Inoue; Dai Nakae; Akiyoshi Nishikawa
JOURNAL OF TOXICOLOGICAL SCIENCES, Jun. 2011, [Reviewed] - Importance of Researches on Chronic Effects by Manufactured Nanomaterials
Akihiko Hirose; Atsuya Takagi; Tetsuji Nishimura; Hiroyuki Tsuda; Yoshimitsu Sakamoto; Akio Ogata; Dai Nakae; Okio Hino; Jun Kanno
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Feb. 2011, [Reviewed] - Neurobehavioural effects of clothianidin in two-generation toxicity study in mice.
Tanaka Toyohito; Takahashi Osamu; Ohyama Ken-ichi; Ogata Akio; Nakae Dai
Annual Meeting of the Japanese Society of Toxicology, 2011 - Parenteral paradichlorobenzene exposure reduces sperm production, alters sperm morphology and exhibits an androgenic effect in rats and mice
Osamu Takahashi; Norio Ohashi; Dai Nakae; Akio Ogata
FOOD AND CHEMICAL TOXICOLOGY, Jan. 2011, [Reviewed] - Low-dose carcinogenicity of 2-amino-3-methylimidazo[4,5-f ]quinoline in rats: Evidence for the existence of no-effect levels and a mechanism involving p21(Cip/WAF1)
Min Wei; Hideki Wanibuchi; Dai Nakae; Hiroyuki Tsuda; Satoru Takahashi; Masao Hirose; Yukari Totsuka; Masae Tatematsu; Shoji Fukushima
CANCER SCIENCE, Jan. 2011, [Reviewed] - Mitochondrial dysfunction and biotransformation of beta-carboline alkaloids, harmine and harmaline, on isolated rat hepatocytes
Yoshio Nakagawa; Toshinari Suzuki; Hidemi Ishii; Akio Ogata; Dai Nakae
CHEMICO-BIOLOGICAL INTERACTIONS, Dec. 2010, [Reviewed] - Proliferative and Nonproliferative Lesions of the Rat and Mouse Hepatobiliary System
Bob Thoolen; Robert R. Maronpot; Takanori Harada; Abraham Nyska; Colin Rousseaux; Thomas Nolte; David E. Malarkey; Wolfgang Kaufmann; Karin Kuettler; Ulrich Deschl; Dai Nakae; Richard Gregson; Michael P. Vinlove; Amy E. Brix; Bhanu Singh; Fiorella Belpoggi; Jerrold M. Ward
TOXICOLOGIC PATHOLOGY, Dec. 2010, [Reviewed] - Toxicological evaluation of l-proline in a 90-day feeding study with Fischer 344 rats
Y. Tada; N. Yano; H. Takahashi; K. Yuzawa; H. Ando; Y. Kubo; A. Nagasawa; N. Ohashi; A. Ogata; D. Nakae
Regulatory Toxicology and Pharmacology, Oct. 2010, [Reviewed] - Serum level of expressed in renal carcinoma (ERC)/mesothelin in rats with mesothelial proliferative lesions induced by multi-wall carbon nanotube (MWCNT)
Yoshimitsu Sakamoto; Dai Nakae; Yoshiaki Hagiwara; Kanako Satoh; Norio Ohashi; Katsumi Fukamachi; Hiroyuki Tsuda; Akihiko Hirose; Tetsuji Nishimura; Okio Hino; Akio Ogata
JOURNAL OF TOXICOLOGICAL SCIENCES, Apr. 2010, [Reviewed] - Effects of maternal clothianidin exposure on behavioral development in F1-generation mice
TANAKA Toyohito; TAKAHASHI Osamu; OISHI Shinshi; OHASHI Norio; NAKAE Dai; OGATA Akio
Annual Meeting of the Japanese Society of Toxicology, 2010 - Increase in in Utero Exposure to a Migrant, 4,4 '-Butylidenebis(6-t-butyl-m-cresol), from Nitrile-Butadiene Rubber Gloves on Brain Aromatase Activity in Male Rats
Kanako Satoh; Ryouichi Nonaka; Dai Nakae; Akio Ogata
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Jan. 2010, [Reviewed] - A 90-day Feeding Toxicity Study of L-Serine in Male and Female Fischer 344 Rats
Yukie Tada; Norio Yano; Hiroshi Takahashi; Katsuhiro Yuzawa; Hiroshi Ando; Yoshikazu Kubo; Akemichi Nagasawa; Keigi Chin; Yasuko Kawamata; Ryosei Sakai; Norio Ohashi; Akio Ogata; Dai Nakae
JOURNAL OF TOXICOLOGIC PATHOLOGY, 2010, [Reviewed] - Enhancement of lung carcinogenesis initiated with 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone by Ogg1 gene deficiency in female, but not male, mice
Maki Igarashi; Manabu Watanabe; Midori Yoshida; Kouichi Sugaya; Yoshifumi Endo; Nozomi Miyajima; Masayoshi Abe; Sumio Sugano; Dai Nakae
JOURNAL OF TOXICOLOGICAL SCIENCES, Apr. 2009, [Reviewed] - Induction of mesothelioma by a single intrascrotal administration of multi-wall carbon nanotube in intact male Fischer 344 rats
Yoshimitsu Sakamoto; Dai Nakae; Nobutaka Fukumori; Kuniaki Tayama; Akihiko Maekawa; Kiyoshi Imai; Akihiko Hirose; Tetsuji Nishimura; Norio Ohashi; Akio Ogata
JOURNAL OF TOXICOLOGICAL SCIENCES, Feb. 2009, [Reviewed] - Possible Involvement of Adaptation Mechanisms in the Achievement of an Ineffective Dose Range for the Carcinogenicity of Genotoxic Carcinogens
Nakae Dai; Wanibuchi Hideki; Konishi Yoichi; Fukushima Shoji
Genes and environment : the official journal of the Japanese Environmental Mutagen Society, 20 Nov. 2008 - Toxic effects of L-aspartic acid at high dose levels on kidneys and salivary glands in Fischer 344 rats detected in a 90-day feeding study
Y. Tada; N. Yano; H. Takahashi; K. Yuzawa; H. Ando; Y. Kubo; A. Nagasawa; S. Uehara; A. Ogata; D. Nakae
FOOD AND CHEMICAL TOXICOLOGY, Aug. 2008, [Reviewed] - Carcinogenic risk of copper gluconate evaluated by a rat medium-term liver carcinogenicity bioassay protocol
Masayoshi Abe; Koji Usuda; Seigo Hayashi; Izumi Ogawa; Satoshi Furukawa; Maki Igarashi; Dai Nakae
ARCHIVES OF TOXICOLOGY, Aug. 2008, [Reviewed] - Possible carcinogenic risks of copper gluconate and their prevention by co-administered green tea catechins evaluated by a rat medium-term multi-organ carcinogenicity bioassay protocol
Masayoshi Abe; Noriko Suzuki; Midori Yoshida; Koji Usuda; Satoshi Furukawa; Lekh Rai Junela; Tsutomu Okubo; Dai Nakae
FOOD AND CHEMICAL TOXICOLOGY, May 2008, [Reviewed] - Points to consider on the non-clinical safety evaluation of anticancer drugs
Dai Nakae; Horoshi Onodera; Osamu Fueki; Tsutomu Urano; Noriyuki Komiyama; Fumio Sagami; Shuichi Kai; Chihiro Nishimura; Tohru Inoue
JOURNAL OF TOXICOLOGICAL SCIENCES, May 2008, [Reviewed] - Ogg1欠損マウスにおけるNNK誘発肺増殖性病変のEGFR突然変異
五十嵐 麻希; 吉田 緑; 渡邊 学; 阿部 正義; 菅野 純夫; 中江 大
日本毒性病理学会講演要旨集, Feb. 2008 - Effects of piperonyl butoxide on spontaneous behaviour in F1 generation mice.
Tanaka Toyohito; Takahashi Osamu; Oishi Shinshi; Ogata Akio; Nakae Dai
Annual Meeting of the Japanese Society of Toxicology, 2008 - Involvement of mutation-based inhibition of beta-catenin phosphorylation at ser33 in the malignant progression of lung (Pre)neoplastic lesions induced by N-nitrosobis(2-hydroxypropyl)amine in male fischer 344 rats
Maki Igarashi; Midori Yoshida; Manabu Watanabe; Toshiyuki Yamada; Takuya Sakurai; Yoshifumi Endo; Nozomi Miyajima; Akihiko Maekawa; Tsuneyuki Oikawa; Sumio Sugano; Dai Nakae
LUNG, Sep. 2007, [Reviewed] - Effects of Oseltamivir phosphate (Tamiflu) and its metabolite (GS4071) on monoamine neurotransmission in the rat brain
Kanako Satoh; Ryouichi Nonaka; Akio Gata; Dai Nakae; Shin-Ichi Uehara
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Sep. 2007, [Reviewed] - OGG1欠損マウスにおけるNNKの発がん性感受性(Lung Carcinogenesis Induced by NNK in Ogg1 Knockout Mice)
五十嵐 麻希; 吉田 緑; 渡邉 学; 阿部 正義; 菅野 純夫; 中江 大
日本癌学会総会記事, Aug. 2007 - Carcinogenicity of dimethylarsinic acid in Ogg1-deficient mice
Anna Kinoshita; Hideki Wanibuchi; Keiichirou Morimura; Min Wei; Dai Nakae; Tsuyoshi Arai; Osamu Minowa; Tetsuo Noda; Susumu Nishimura; Shoji Fukushima
CANCER SCIENCE, Jun. 2007, [Reviewed] - Expression of inducible nitric oxide (NO) synthase but not prevention by its gene ablation of hepatocarcinogenesis with fibrosis caused by a choline-deficient, L-amino acid-defined diet in rats and mice
Ayumi Denda; Wakashi Kitayama; Hideki Kishida; Nao Murata; Kazutoshi Tamura; Osamu Kusuoka; Masahiro Tsutsumi; Fumiko Nishikawa; Eiji Kita; Dai Nakae; Yoichi Konishi; Hiroki Kuniyasu
NITRIC OXIDE-BIOLOGY AND CHEMISTRY, Feb. 2007, [Reviewed] - OGG1遺伝子欠損マウスにおけるNNKの肺発がん性
五十嵐 麻希; 吉田 緑; 渡邊 学; 菅野 澄夫; 中江 大
日本毒性病理学会講演要旨集, Jan. 2007 - Preliminary evaluation of toxicologic and carcinogenic risks of copper gluconate in rats given multiple carcinogens
Masayoshi Abe; Noriko Suzuki; Midori Yoshida; Maki Igarashi; Koji Usuda; Satoshi Furukawa; Akihiko Maekawa; Lekh Raj Juneja; Tsutomu Okubo; Dai Nakae
Journal of Toxicologic Pathology, 10 Oct. 2006, [Reviewed] - N-nitrosobis(hydroxypropyl)amine(BHP)誘発肺増殖性病変の悪性化とβ-Catenin活性の相関についての検討
五十嵐 麻希; 渡邊 学; 吉田 緑; 山田 俊幸; 櫻井 拓也; 前川 昭彦; 及川 恒之; 菅野 澄夫; 中江 大
日本癌学会総会記事, Sep. 2006 - ラット中期多臓器発がん性試験法を用いたカテキン及びグルコン酸銅の発がんリスクの評価
阿部 正義; 吉田 緑; 五十嵐 麻希; Juneja Lekh; 中江 大
日本癌学会総会記事, Sep. 2006 - コリン欠乏アミノ酸(CDAA)食によるマウス肝発がんに対するOgg1遺伝子欠損の修飾効果
傳田 阿由美; 中江 大; 笹平 智則; 木下 アンナ; 鰐渕 英機; 福島 昭治; 國安 弘基
日本癌学会総会記事, Sep. 2006 - Methylation of neutral endopeptidase 24.11 promoter in rat hepatocellular carcinoma
F Uematsu; M Takahashi; M Yoshida; M Igarashi; D Nakae
CANCER SCIENCE, Jul. 2006, [Reviewed] - Disruption of spermatogenic cell adhesion and male infertility in mice lacking TSLC1/IGSF4, an immunoglobulin superfamily cell adhesion molecule
D Yamada; M Yoshida; YN Williams; T Fukami; S Kikuchi; M Masuda; T Maruyama; T Ohta; D Nakae; A Maekawa; T Kitamura; Y Murakami
MOLECULAR AND CELLULAR BIOLOGY, May 2006, [Reviewed] - Inhibition of putrescine Aminopropyltransferase influences rat liver regeneration
Masaki Kobayashi; Koichi Takao; Yasuo Shiota; Yoshiaki Sugita; Masakazu Takahashi; Dai Nakae; Keijiro Samejima
BIOLOGICAL & PHARMACEUTICAL BULLETIN, May 2006, [Reviewed] - Evaluation of effects of catechin and copper gluconate in a rat multi-organ carcinogenesis model
Abe Masayoshi; Suzuki Noriko; Yoshida Midori; Igarashi Maki; Usuda Kouji; Furukawa Satoshi; Uematsu Fumiyuki; Takahashi Masakazu; Maekawa Akihiko; Nakae Dai
Annual Meeting of the Japanese Society of Toxicology, 2006 - 雄性マウスにおけるNNK誘発肺発がん
五十嵐 麻希; 吉田 緑; 高橋 正一; 植松 史行; 前川 昭彦; 中江 大
日本毒性病理学会講演要旨集, Dec. 2005 - 食品中金属類と食品中化学物質の複合による発がんリスクに関する実験的研究 カテキン及びグルコン酸銅を用いたラット中期多臓器発がん性試験法による検討(1)
阿部 正義; 鈴木 紀子; 吉田 緑; 五十嵐 麻希; 臼田 浩二; 古川 賢; 植松 史行; 高橋 正一; 前川 明彦; 中江 大
日本毒性病理学会講演要旨集, Dec. 2005 - Mmh/OGG1ノックアウトマウスにおけるpentachlorophenolの肝発癌感受性
吉田 緑; 渡邊 直人; 五十嵐 麻希; 中江 大
日本疾患モデル学会記録, Nov. 2005 - Temporal correlation of pathology and DNA damage with gene expression in a choline-deficient model of rat liver injury
CL Powell; O Kosyk; BU Bradford; JS Parker; EK Lobenhofer; A Denda; F Uematsu; D Nakae; Rusyn, I
HEPATOLOGY, Nov. 2005, [Reviewed] - Expression of profiles of cytochrome P450 enzymes in the uterus and liver of female rats treated with indole-3-carbinol(Liver, Alimentary system, Proceedings of the 32nd Annual Meeting)
YOSHIDA Midori; NAKAE Dai; MAEKAWA Akihiko
Journal of toxicological sciences, 31 Oct. 2005 - 新規抗酸化物質4-hydroxyphenyl N-tert-butyl nitroneのラットにおける内因性肝細胞がん誘発に対する抑制効果
中江 大; 植松 史行; 高橋 正一; 吉田 緑; 五十嵐 麻希; 前川 昭彦; 小西 陽一; 古武 弥成; ロバート・A・フロイド
日本癌学会総会記事, Sep. 2005 - ラット肺腺がんの発生過程におけるβ-カテニンの変化に関する検索
五十嵐 麻希; 吉田 緑; 山田 俊幸; 櫻井 拓也; 植松 史行; 高橋 正一; 前川 昭彦; 及川 恒之; 中江 大
日本癌学会総会記事, Sep. 2005 - ラットにおけるコリン欠乏アミノ酸食前処置のaminophenylnorharmanの肝臓および大腸発がん性に及ぼす影響
高橋 正一; 戸塚 ゆ加里; 高橋 真美; 植松 史行; 五十嵐 麻希; 吉田 緑; 前川 昭彦; 若林 敬二; 中江 大
日本癌学会総会記事, Sep. 2005 - Distinct patterns of gene expression in hepatocellular carcinomas and adjacent non-cancerous, cirrhotic liver tissues in rats fed a choline-deficient, L-amino acid-defined diet
F Uematsu; M Takahashi; M Yoshida; M Igarashi; N Watanabe; N Suzuki; M Abe; Rusyn, I; RA Floyd; D Nakae
CANCER SCIENCE, Jul. 2005, [Reviewed] - Exercise training enhances tumor necrosis factor-alpha-induced expressions of anti-apoptotic genes without alterations in caspase-3 activity in rat epididymal adipocytes
T Sakurai; M Takei; J Ogasawara; N Watanabe; M Sanpei; M Yoshida; D Nakae; T Sakurai; N Nakano; T Kizaki; H Ohno; T Izawa
JAPANESE JOURNAL OF PHYSIOLOGY, Jun. 2005, [Reviewed] - Lack elf potential of low dose N-nitrosodimethylamine to induce preneoplastic lesions, glutathione S-transferase placental form-positive foci, in rat liver
S Fukushima; H Wanibuchi; K Morimura; D Nakae; H Tsuda; K Imaida; T Shirai; M Tatematsu; T Tsukamoto; M Hirose; F Furukawa
CANCER LETTERS, May 2005, [Reviewed] - Differentially altered protein expression profiles with early phase hepatocarcinogenesis in Nagase analbuminemic rats and Sprague-Dawley rat by 3'-Me-DAB
A. H.; T. M.; U. F.; I. M.; A. M.; Y. M.; M. A.; M. M.; N. D.
Japan Journal of Molecular Tumor Marker Research, 2005 - α-smooth muscle actin-positive stromal cells reactive to estrogens surround endometrial glands in rats but not mice
Takasumi Shimomoto; Midori Yoshida; Shin-Ichi Katsuda; Masakazu Takahashi; Fumiyuki Uematsu; Hiroki Kuniyasu; Akihiko Maekawa; Dai Nakae
Journal of Toxicologic Pathology, 2005, [Reviewed] - Nitric oxide production by primary liver cells isolated from amino acid diet-fed rats
Y Kotake; H Kishida; D Nakae; RA Floyd
NITRIC OXIDE, PT E, 2005, [Reviewed] - Induction of DNA-adducts and increase of 8-hydroxy-2-deoxyguanosine, but no development of preneoplastic lesions in offspring liver with transplacental and trans-breast milk exposure to 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MelQx) in rats
T Ichihara; H Wanibuchi; Y Totsuka; K Morimura; M Wei; D Nakae; S Fukushima
CANCER SCIENCE, Dec. 2004, [Reviewed] - Dietary indole-3-carbinol promotes endometrial adenocarcinoma development in rats initiated with N-ethyl-N '-nitro-N-nitrosoguanidine, with induction of cytochrome P450s in the liver and consequent modulation of estrogen metabolism
M Yoshida; S Katashima; J Ando; T Tanaka; F Uematsu; D Nakae; A Maekawa
CARCINOGENESIS, Nov. 2004, [Reviewed] - Effects of estrogens and metabolites on endometrial carcinogenesis in young adult mice initiated with N-ethyl-N'-nitro-N-nitrosoguanidine
M Takahashi; T Shimomoto; K Miyajima; M Yoshida; S Katashima; F Uematsu; A Maekawa; D Nakae
CANCER LETTERS, Jul. 2004, [Reviewed] - Chemopreventive effects of hydroxymatairesinol on uterine carcinogenesis in Donryu rats
S Katsuda; M Yoshida; N Saarinen; A Smeds; D Nakae; R Santti; A Maekawa
EXPERIMENTAL BIOLOGY AND MEDICINE, May 2004, [Reviewed] - Lack of toxicity or carcinogenicity of S-170, a sucrose fatty acid ester, in F344 rats
M Yoshida; S Katsuda; D Nakae; A Maekawa
FOOD AND CHEMICAL TOXICOLOGY, Apr. 2004, [Reviewed] - Inhibition of the development of hepatocellular carcinomas by phenyl N-tert-butyl nitrone in rats fed with a choline-deficient, L-amino acid-defined diet
D Nakae; F Uematsu; H Kishida; O Kusuoka; S Katsuda; M Yoshida; M Takahashi; A Maekawa; A Denda; Y Konishi; Y Kotake; RA Floyd
CANCER LETTERS, Mar. 2004, [Reviewed] - A case report of a choroid plexus carcinoma spontaneously occurring in the right lateral ventricle of a 14-week-old, female Donryu rat
T Shimomoto; M Yoshida; M Takahashi; F Uematsu; A Maekawa; D Nakae
TOXICOLOGIC PATHOLOGY, Mar. 2004, [Reviewed] - α-Naphthylisothiocyanate Induces Intrahepatic Bile Duct with Greater Proliferation in Female Rats than in Males
Fumiyuki Uematsu; Midori Yoshida; Masakazu Takahashi; Masayoshi Abe; Maki Igarashi; Naoto Watanabe; Noriko Suzuki; Akihiko Maekawa; Dai Nakae
Journal of Toxicologic Pathology, 2004, [Reviewed] - Post-initiation inhibition of MeIQx hepatocarcinogenesis in rats by cysteine.
Ogawa M; Wanibuchi H; Nishkawa T; Yano Y; Otani S; Totsuka Y; Wakabayashi K; Nakae D; Fukushima S
Osaka city medical journal, Jun. 2003, [Reviewed] - Lack of initiation activity in rat liver of low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline
S Fukushima; H Wanibuchi; K Morimura; M Wei; D Nakae; Y Konishi; H Tsuda; N Takasuka; K Imaida; T Shirai; M Tatematsu; T Tsukamoto; M Hirose; F Furukawa
CANCER LETTERS, Feb. 2003, [Reviewed] - Effects of maternal exposure to nonylphenol on growth and development of the female reproductive system and uterine carcinogenesis in rats.
Yoshida, M; Shimomoto, T; Katashima, S; Shirai, T; Nakae, D; Watanabe, G; Taya, K; Maekawa, A
J Toxicol Pathol, 2003, [Reviewed] - Value of GST-P positive preneoplastic hepatic foci in dose-response studies of hepatocarcinogenesis: Evidence for practical thresholds with both genotoxic and nongenotoxic carcinogens. A review of recent work
H Tsuda; S Fukushima; H Wanibuchi; K Morimura; D Nakae; K Imaida; M Tatematsu; M Hirose; K Wakabayashi; MA Moore
TOXICOLOGIC PATHOLOGY, Jan. 2003, [Reviewed] - Effects of phenyl N-tert-butyl nitrone and its derivatives on the early phase of hepatocarcinogenesis in rats fed a choline-deficient, L-amino acid-defined diet
D Nakae; H Kishida; T Enami; Y Konishi; KL Hensley; RA Floyd; Y Kotake
CANCER SCIENCE, Jan. 2003, [Reviewed] - Induction of different types of uterine adenocarcinomas in Donryu rats due to neonatal exposure to high-dose p-t-octylphenol for different periods
M Yoshida; S Katsuda; T Tanimoto; S Asai; D Nakae; Y Kurokawa; K Taya; A Maekawa
CARCINOGENESIS, Oct. 2002, [Reviewed] - Lack of a dose-response relationship for carcinogenicity in the rat liver with low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-nitrosodiethylamine
S Fukushima; H Wanibuchi; K Morimura; M Wei; D Nakae; Y Konishi; H Tsuda; N Uehara; K Imaida; T Shirai; M Tatematsu; T Tsukamoto; M Hirose; F Furukawa; K Wakabayashi; Y Totsuka
JAPANESE JOURNAL OF CANCER RESEARCH, Oct. 2002, [Reviewed] - Inhibitory effects of lemon grass (Cymbopogon citratus, Stapf) extract on the early phase of hepatocarcinogenesis after initiation with diethylnitrosamine in male Fischer 344 rats
R Puatanachokchai; H Kishida; A Denda; N Murata; Y Konishi; U Vinitketkumnuen; D Nakae
CANCER LETTERS, Sep. 2002, [Reviewed] - Carcinogenicity of dimethylarsinic acid in male F344 rats and genetic alterations in induced urinary bladder tumors
M Wei; H Wanibuchi; K Morimura; S Iwai; K Yoshida; G Endo; D Nakae; S Fukushima
CARCINOGENESIS, Aug. 2002, [Reviewed] - Promoting effects of monomethylarsonic acid, dimethylarsinic acid and trimethylarsine oxide on induction of rat liver preneoplastic glutathione S-transferase placental form positive foci: A possible reactive oxygen species mechanism
T Nishikawa; H Wanibuchi; M Ogawa; A Kinoshita; K Morimura; T Hiroi; Y Funae; H Kishida; D Nakae; S Fukushima
INTERNATIONAL JOURNAL OF CANCER, Jul. 2002, [Reviewed] - Alterations of the Fhit gene in hepatocellular carcinomas induced by N-nitrosodiethylamine in rats
T Tsujiuchi; Y Sasaki; T Kubozoe; M Tsutsumi; Y Konishi; D Nakae
MOLECULAR CARCINOGENESIS, May 2002, [Reviewed] - Reactive oxygen species in choline deficiency induced carcinogenesis and nitrone inhibition
RA Floyd; Y Kotake; K Hensley; D Nakae; Y Konishi
MOLECULAR AND CELLULAR BIOCHEMISTRY, May 2002, [Reviewed] - Immunohistochemical detection of a substituted 1,N-2-ethenodeoxyguanosine adduct by omega-6 polyunsaturated fatty acid hydroperoxides in the liver of rats fed a choline-deficient, L-amino acid-defined diet
Y Kawai; Y Kato; D Nakae; O Kusuoka; Y Konishi; K Uchida; T Osawa
CARCINOGENESIS, Mar. 2002, [Reviewed] - Development of hepatocellular adenomas and carcinomas associated with fibrosis in C57BL/6J male mice given a choline-deficient, L-amino acid-defined diet
A Denda; WA Kitayama; H Kishida; N Murata; M Tsutsumi; T Tsujiuchi; D Nakae; Y Konishi
JAPANESE JOURNAL OF CANCER RESEARCH, Feb. 2002, [Reviewed] - Increased expression of cyclooxygenase-2 protein during rat hepatocarcinogenesis caused by a choline-deficient, L-amino acid-defined diet and chemopreventive efficacy of a specific inhibitor, nimesulide
A Denda; W Kitayama; A Murata; H Kishida; Y Sasaki; O Kusuoka; T Tsujiuchi; M Tsutsumi; D Nakae; H Takagi; Y Konishi
CARCINOGENESIS, Feb. 2002, [Reviewed] - Lack of promoting effect due to oral administration of dimethylarsinic acid on rat lung carcinogenesis initiated with N-bis(2-hydroxypropyl)nitrosamine
N Seike; H Wanibuchi; K Morimura; T Nishikawa; H Kishida; D Nakae; K Hirata; S Fukushima
CANCER LETTERS, Jan. 2002, [Reviewed] - Reactive Oxygen and Nitrogen Oxide Species-induced Stress, a Major Intrinsic Factor Involved in Carcinogenic Processes and a Possible Target for Cancer Prevention.
Nakae D; Umemura T; Kurokawa Y
Asian Pacific journal of cancer prevention : APJCP, 2002, [Reviewed] - The copper-chelating agent, trientine, suppresses tumor development and angiogenesis in the murine hepatocellular carcinoma cells
J Yoshi; H Yoshiji; S Kuriyama; Y Ikenaka; R Noguchi; H Okuda; H Tsujinoue; T Nakatani; H Kishida; D Nakae; DE Gomez; MS De Lorenzo; AM Tejera; H Fukui
INTERNATIONAL JOURNAL OF CANCER, Dec. 2001, [Reviewed] - Increased oxidative DNA damage in mammary tumor cells by continuous epidermal growth factor stimulation
Jun Ichi Hamada; Daichi Nakata; Dai Nakae; Yozo Kobayashi; Hiroyuki Akai; Yoichi Konishi; Futoshi Okada; Toshiyuki Shibata; Masuo Hosokawa; Tetsuya Moriuchi
Journal of the National Cancer Institute, 07 Feb. 2001 - Elevated expression of transforming growth factor βs and the tumor necrosis factor family in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats
T. Tsujiuchi; Y. Sasaki; N. Murata; M. Tsutsumi; D. Nakae; Y. Konishi
Experimental and Toxicologic Pathology, 2001, [Reviewed] - FHIT alterations in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats
Tsujiuchi Tsujiuchi; Yasutaka Sasaki; Nao Murata; Masahiro Tsutsumi; Yoichi Konishi; Dai Nakae
Carcinogenesis, 2001, [Reviewed] - Interleukin-15 expression is associated with malignant potential in colon cancer cells
Hiroki Kuniyasu; Naohide Oue; Dai Nakae; Masahiro Tsutsumi; Ayumi Denda; Toshifumi Tsujiuchi; Hiroshi Yokozaki; Wataru Yasui
Pathobiology, 2001, [Reviewed] - Enhancement of hepatocarcinogenesis initiated with diethylnitrosamine or N-nitrosobis(2-hydroxypropyl)amine by a choline-deficient, L-amino acid-defined diet administered prior to the carcinogen exposure in rats
H Kishida; D Nakae; Y Kobayashi; O Kusuoka; W Kitayama; A Denda; H Fukui; Y Konishi
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, Oct. 2000, [Reviewed] - Dietary choline restriction causes complex I dysfunction and increased H2O2 generation in liver mitochondria
K Hensley; Y Kotake; H Sang; QN Pye; GL Wallis; LM Kolker; T Tabatabaie; CA Stewart; Y Konishi; D Nakae; RA Floyd
CARCINOGENESIS, May 2000, [Reviewed] - Hepatotoxicity and consequently increased cell proliferation are associated with flumequine hepatocarcinogenesis in mice
M Yoshida; K Miyajima; K Shiraki; J Ando; K Kudoh; D Nakae; M Takahashi; A Maekawa
CANCER LETTERS, Jul. 1999, [Reviewed] - Inflammatory cell mediated tumour progression and minisatellite mutation correlate with the decrease of antioxidative enzymes in murine fibrosarcoma cells
F. Okada; K. Nakai; T. Kobayashi; T. Shibata; S. Tagami; Y. Kawakami; T. Kitazawa; R. Kominami; S. Yoshimura; K. Suzuki; N. Taniguchi; O. Inanami; M. Kuwabara; H. Kishida; D. Nakae; Y. Konishi; T. Moriuchi; M. Hosokawa
British Journal of Cancer, 1999 - Single treatment with cisplatin or UFT, but not their combination treatment enhances the metastatic capacity of mouse fibrosarcoma cells
Sungki Choi; Futoshi Okada; Masanobu Kobayashi; Hasem Habelhah; Dai Nakae; Yoichi Konishi; Yasunori Totsuka; Masuo Hosokawa
Anti-Cancer Drugs, 1999, [Reviewed] - Inhibition by phenyl N-tert-butyl nitrone of early phase carcinogenesis in the livers of rats fed a choline-deficient, L-amino acid-defined diet
Dai Nakae; Yashige Kotake; Hideki Kishida; Kenneth L. Hensley; Ayumi Denda; Yozo Kobayashi; Wakashi Kitayama; Toshifumi Tsujiuchi; Hong Sang; Charles A. Stewart; Tahereh Tabatabaie; Robert A. Floyd; Yoichi Konishi
Cancer Research, 15 Oct. 1998, [Reviewed] - Prevention by 1'-acetoxychavicol acetate of the induction but not growth of putative preneoplastic, glutathione S-transferase placental form-positive, focal lesions in the livers of rats fed a choline-deficient, L-amino acid-defined diet
Yozo Kobayashi; Dai Nakae; Hiroyuki Akai; Hideki Kishida; Eijiro Okajima; Wakashi Kitayama; Ayumi Denda; Toshifumi Tsujiuchi; Akira Murakami; Koichi Koshimizu; Hajime Ohigashi; Yoichi Konishi
Carcinogenesis, Oct. 1998, [Reviewed] - Increased telomerase activity in intrahepatic cholangiocellular carcinomas induced by N-nitrosobis(2-oxopropyl)amine in hamsters
Katsumichi Iki; Toshifumi Tsujiuchi; Toshimitsu Majima; Hiroyuki Sakitani; Masahiro Tsutsumi; Makoto Takahama; Masatoshi Yoshimoto; Dai Nakae; Tsukasa Tsunoda; Yoichi Konishi
Cancer Letters, 25 Sep. 1998, [Reviewed] - Prevention by inhibitors of arachidonic acid cascade of liver carcinogenesis, cirrhosis and oxidative DNA damage caused by a choline- deficient, L-amino acid-defined diet in rats
Ayumi Denda; Takehiro Endoh; Qing Tang; Toshifumi Tsujiuchi; Dai Nakae; Yoichi Konishi
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 18 Jun. 1998, [Reviewed] - Increased telomerase activity and absence of p53 mutation in oligo-astrocytomas induced by N-ethyl-N-nitrosourea in rats
Hiroyuki Sakitani; Toshifumi Tsujiuchi; Kunihiko Kobitsu; Akira Kido; Katsumichi Iki; Makoto Takahama; Mitsuhiro Nakamura; Toshisuke Sakaki; Dai Nakae; Yoichi Konishi; Masahiro Tsutsumi
Cancer Letters, 24 Apr. 1998, [Reviewed] - Inhibition of early-phase exogenous and endogenous liver carcinogenesis in transgenic rats harboring a rat glutathione S-transferase placental form gene
Dai Nakae; Ayumi Denda; Yozo Kobayashi; Hiroyuki Akai; Hideki Kishida; Toshifumi Tsujiuchi; Yoichi Konishi; Toshiya Suzuki; Masami Muramatsu
Japanese Journal of Cancer Research, 1998, [Reviewed] - Systemic mast cell disease with splenic infarction: A case report
Hiroshi Maruyama; Seiichi Sugihara; Kyoko Ishihara; Kazuo Sada; Masahiro Tsutsumi; Toshifumi Tsujiuchi; Dai Nakae; Yoichi Konishi
Pathology International, 1998, [Reviewed] - Inhibition by N-(4-hydroxyphenyl)retinamide and all-trans-retinoic acid of exogenous and endogenous development of putative preneoplastic, glutathione S-transferase placental form-positive lesions in the livers of rats
Kazutoshi Tamura; Dai Nakae; Kohsuke Horiguchi; Hiroyuki Akai; Yozo Kobayashi; Nobuaki Andoh; Hiroshi Satoh; Ayumi Denda; Toshifumi Tsujiuchi; Hitoshi Yoshiji; Yoichi Konishi
Carcinogenesis, Nov. 1997, [Reviewed] - Inhibition by piroxicam of oxidative DNA damage, liver cirrhosis and development of enzyme-altered nodules caused by a choline-deficient, L-amino acid-defined diet in rats
Ayumi Denda; Takehiro Endoh; Wakashi Kitayama; Qing Tang; Osamu Noguchi; Yozoh Kobayashi; Hiroyuki Akai; Eijiroh Okajima; Toshifumi Tsujiuchi; Masahiro Tsutsumi; Dai Nakae; Yoichi Konishi
Carcinogenesis, Oct. 1997, [Reviewed] - Involvement of 8-hydroxyguanine formation in the initiation of rat liver carcinogenesis by low dose levels of N-nitrosodiethylamine
D Nakae; Y Kobayashi; H Akai; N Andoh; H Satoh; K Ohashi; M Tsutsumi; Y Konishi
CANCER RESEARCH, Apr. 1997, [Reviewed] - Chronic toxicity and carcinogenicity studies of 2-methylnaphthalene in B6C3F1 mice
Yoshiaki Murata; Ayumi Denda; Hiroshi Maruyama; Dai Nakae; Masahiro Tsutsumi; Toshifumi Tsujiuchi; Yoichi Konishi
Fundamental and Applied Toxicology, 1997, [Reviewed] - Inhibition by green tea extract of diethylnitrosamine-initiated but not choline-deficient, L-amino acid-defined diet-associated development of putative preneoplastic, glutathione S-transferase placental form-positive lesions in rat liver
Kazutoshi Tamura; Dai Nakae; Kohsuke Horiguchi; Hiroyuki Akai; Yozo Kobayashi; Hiroshi Satoh; Toshifumi Tsujiuchi; Ayumi Denda; Yoichi Konishi
Japanese Journal of Cancer Research, 1997, [Reviewed] - Infrequent Ki-ras and an absence of p53 mutations in hepatocellular carcinomas induced by a choline deficient L-amino acid defined diet in rats
Toshifumi Tsujiuchi; Akira Kido; Dai Nakae; Makoto Takahama; Toshimitsu Majima; Kunihiko Kobitsu; Eijiro Okajima; Masahiro Tsutsumi; Ayumi Denda; Yoichi Konishi
Cancer Letters, 12 Nov. 1996, [Reviewed] - Increased telomerase activities in hyperplastic nodules and hepatocellular carcinomas induced by a choline deficient L-amino acid defined diet in rats
T Tsujiuchi; M Tsutsumi; K Kobitsu; T Majima; A Denda; D Nakae; Y Konishi
RECENT ADVANCES IN GASTROENTEROLOGICAL CARCINOGENESIS I, 1996, [Reviewed] - Effects of inhibitors of arachidonic acid cascade on the liver carcinogenesis by a choline-deficient, L-amino acid-defined diet in rats
A Denda; T Endoh; Q Tang; T Tsujiuchi; D Nakae; Y Konishi
RECENT ADVANCES IN GASTROENTEROLOGICAL CARCINOGENESIS I, 1996, [Reviewed] - Inhibition by N-(4-hydroxyphenyl) retinamide of exogenous and endogenous liver carcinogenesis in rats
D Nakae; K Tamura; H Akai; Y Kobayashi; K Horiguchi; A Denda; Y Konishi
RECENT ADVANCES IN GASTROENTEROLOGICAL CARCINOGENESIS I, 1996, [Reviewed] - Inhibition by acetylsalicylic acid, a cyclo-oxygenase inhibitor, and p-bromophenacylbromide, a phospholipase A2 inhibitor, of both cirrhosis and enzyme-altered nodules caused by a choline-deficient, L-amino acid-defined diet in rats
Takehiro Endoh; Qing Tang; Ayumi Denda; Osamu Noguchi; Eisaku Kobayashi; Kazutoshi Tamura; Kohsuke Horiguchi; Hiroyuki Ogasawara; Toshifumi Tsujiuchi; Dai Nakae; Masahito Sugimura; Yoichi Konishi
Carcinogenesis, 1996, [Reviewed] - Inhibitory effects of N,N′-diphenyl-p-phenylenediamine on the early stage of the enhanced hepatocarcinogenesis caused by coadministration of ethionine and a choline-deficient L-amino acid-defined diet in rats
Eisaku Kobayashi; Toshifumi Tsujiuchi; Dai Nakae; Yasushi Mizumoto; Nobuaki Andoh; Takehiro Endoh; Hiromichi Kitada; Masahiro Tsutsumi; Ayumi Denda; Yoichi Konishi
Experimental and Toxicologic Pathology, 1996, [Reviewed] - Increased telomerase activity in hyperplastic nodules and hepatocellular carcinomas induced by a choline-deficient L-amino acid-defined diet in rats
Toshifumi Tsujiuchi; Masahiro Tsutsumi; Akira Kido; Kunihiko Kobitsu; Makoto Takahama; Toshimitsu Majima; Ayumi Denda; Dai Nakae; Yoichi Konishi
Japanese Journal of Cancer Research, 1996, [Reviewed] - Prevention by methionine of enhancement of hepatocarcinogenesis by coadministration of a choline-deficient l-amino acid-defined diet and ethionine in rats
Toshifumi Tsujiuchi; Eisaku Kobayashi; Dai Nakae; Yasushi Mizumoto; Nobuaki Andoh; Hiromichi Kitada; Kazuo Ohashi; Tomokazu Fukuda; Akira Kido; Masahiro Tsutsumi; Ayumi Denda; Yoichi Konishi
Japanese Journal of Cancer Research, Dec. 1995, [Reviewed] - IMPROVED GENOMIC NUCLEAR-DNA EXTRACTION FOR 8-HYDROXYDEOXYGUANOSINE ANALYSIS OF SMALL AMOUNTS OF RAT-LIVER TISSUE
D NAKAE; Y MIZUMOTO; E KOBAYASHI; O NOGUCHI; Y KONISHI
CANCER LETTERS, Nov. 1995, [Reviewed] - Comparative changes in the liver of female Fischer-344 rats after short- term feeding of a semipurified or a semisynthetic L-amino acid-defined choline-deficient diet
D. Nakae; Y. Mizumoto; N. Andoh; K. Tamura; K. Horiguchi; T. Endoh; E. Kobayashi; T. Tsujiuchi; A. Denda; B. Lombardi; Y. Konishi
Toxicologic Pathology, 1995, [Reviewed] - PROTECTION AGAINST LIPID-PEROXIDATION INDUCED DURING PRESERVATION OF LUNGS FOR TRANSPLANTATION
K NEZU; K KUSHIBE; T TOJO; N SAWABATA; K KAWACHI; Y MIZUMOTO; D NAKAE; Y KONISHI; S KITAMURA
JOURNAL OF HEART AND LUNG TRANSPLANTATION, Nov. 1994, [Reviewed] - CLINICAL CHARACTERISTICS AND PROLIFERATING ACTIVITY OF INTRAHEPATIC CHOLANGIOCARCINOMA
K OHASHI; Y NAKAJIMA; M TSUTSUMI; H KANEHIRO; T FUKUOKA; M HISANAGA; J TAKI; D NAKAE; Y KONISHI; H NAKANO
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Sep. 1994, [Reviewed] - SELECTIVE 8-HYDROXYGUANINE FORMATION IN PANCREATIC DNA DUE TO A SINGLE INTRAVENOUS ADMINISTRATION OF 4-HYDROXYAMINOQUINOLINE 1-OXIDE IN RATS
D NAKAE; N ANDOH; Y MIZUMOTO; T ENDOH; N SHIMOJI; K HORIGUCHI; K SHIRAIWA; K TAMURA; A DENDA; Y KONISHI
CANCER LETTERS, Aug. 1994, [Reviewed] - Prevention by acetylsailcylic acid of liver cirrhosis and carcinogenesis as well as generations of 8-hydroxydeoxyguanosine and thiobarbituric acid-reactive substances caused by a choline-deficient, l-amino acid-defined diet in rats
Ayumi Denda; Qing Tang; Takehiro Endoh; Toshifumi Tsujiuchi; Kohsuke Horiguchi; Osamu Noguchi; Yasushi Mizumoto; Dai Nakae; Yoichi Konishi
Carcinogenesis, Jun. 1994, [Reviewed] - DIFFERENT ROLES OF 8-HYDROXYGUANINE FORMATION AND 2-THIOBARBITURIC ACID-REACTING SUBSTANCE GENERATION IN THE EARLY PHASE OF LIVER CARCINOGENESIS INDUCED BY A CHOLINE-DEFICIENT, L-AMINO ACID-DEFINED DIET IN RATS
D NAKAE; Y MIZUMOTO; H YOSHIJI; N ANDOH; K HORIGUCHI; K SHIRAIWA; E KOBAYASHI; T ENDOH; N SHIMOJI; K TAMURA; T TSUJIUCHI; A DENDA; Y KONISHI
JAPANESE JOURNAL OF CANCER RESEARCH, May 1994, [Reviewed] - Inhibitory effects of 2-o-octadecylascorbic acid and other vitamin C and e derivatives on the induction of enzyme-altered putative preneoplastic lesions in the livers of rats fed a choline-deficient, l-amino acid-defined diet
Yasushi Mizumoto; Dai Nakae; Hitoshi Yoshiji; Nobuaki Andoh; Kohsuke Horiguchi; Takehiro Endoh; Eisaku Kobayashi; Toshifumi Tsujiuchi; Naoshi Shimoji; Ayumi Denda; Tadasu Tsujii; Minako Nagao; Keiji Wakabayashi; Yoichi Konishi
Carcinogenesis, Feb. 1994, [Reviewed] - DISSOCIATED INHIBITORY EFFECTS OF N,N'-DIPHENYL-P-PHENYLENEDIAMINE, ON RAT-LIVER CARCINOGENESIS BY A CHOLINE-DEFICIENT L-AMINO-ACID DEFINED DIET
D NAKAE; Y MIZUMOTO; N ANDOH; T ENDOH; E KOBAYASHI; T TSUJIUCHI; A DENDA; Y KONISHI
FRONTIERS OF REACTIVE OXYGEN SPECIES IN BIOLOGY AND MEDICINE, 1994, [Reviewed] - PREVENTION BY INHIBITORS OF ARACHIDONIC-ACID (AA) METABOLISM OF LIVER-CIRRHOSIS AND CARCINOGENESIS CAUSED BY CHOLINE-DEFICIENT L-AMINO ACID-DEFINED (CDAA) DIET ASSOCIATED WITH THEIR INHIBITION OF THE INDUCTION OF LIPID-PEROXIDATION AND 8-HYDROXYDEOXYGUANOSINE (8-OHDG)
A DENDA; T ENDOH; Q TANG; T TSUJIUCHI; O NOGUCHI; N ANDOH; Y MIZUMOTO; D NAKAE; Y KONISHI
FRONTIERS OF REACTIVE OXYGEN SPECIES IN BIOLOGY AND MEDICINE, 1994, [Reviewed] - Effects of oxidative stress induced by redox-enzyme modulation on the progression stage of rat hepatocarcinogenesis
Ayumi Denda; Qing Tang; Toshifumi Tsujiuchi; Masahiro Tsutsumi; Toshihiro Amanuma; Yoshiharu Murata; Kazutoshi Tamura; Konsuke Horiguchi; Dai Nakae; Yoichi Konishi
Carcinogenesis, Jan. 1993, [Reviewed] - POSSIBLE ENHANCING EFFECT OF THE IMMUNOSUPPRESSIVE AGENT, 6-MERCAPTOPURINE(6-MP) ON FOCAL LESION DEVELOPMENT IN CIRRHOTIC LIVER INDUCED BY CARBON-TETRACHLORIDE BUT NOT FURFURAL IN F344 RATS
H MARUYAMA; T AMANUMA; Y TAKASHIMA; H YOSHIJI; D NAKAE; M TSUTSUMI; T TSUJIUCHI; A DENDA; Y KONISHI
CARCINOGENESIS, Aug. 1992, [Reviewed] - INHIBITION OF OXY RADICALS MEDIATED LIVER CARCINOGENESIS BY DIETARY IRON-DEFICIENCY IN RATS GIVEN A CHOLINE-DEFICIENT L-AMINO-ACID DEFINED (CDAA) DIET
D NAKAE; Y MIZUMOTO; H YOSHIJI; K HORIGUCHI; A DENDA; Y KONISHI
OXYGEN RADICALS, 1992, [Reviewed] - INHIBITORY EFFECT OF DIETARY IRON-DEFICIENCY ON THE INDUCTION OF PUTATIVE PRENEOPLASTIC FOCI IN RAT-LIVER INITIATED WITH DIETHYLNITROSAMINE AND PROMOTED BY PHENOBARBITAL
H YOSHIJI; D NAKAE; T KINUGASA; M MATSUZAKI; A DENDA; T TSUJII; Y KONISHI
BRITISH JOURNAL OF CANCER, Nov. 1991, [Reviewed] - Effects of catechol and its analogs on pancreatic carcinogenesis initiated by n-nitrosobis(2-oxopropyl)amine in syrian hamsters
Hiroshi Maruyama; Toshihiro Amanuma; Dai Nakae; Masahiro Tsutsumi; Satoshi Kondo; Toshifumi Tsujiuchi; Ayumi Denda; Yoichi Konishi
Carcinogenesis, Jul. 1991, [Reviewed] - Induction of 8-hydroxydeoxyguanosine but not initiation of carcinogenesis by redox enzyme modulations with or without menadione in rat liver
Ayumi Denda; Kimie Sai; Qing Tang; Toshifumi Tsujiuchi; Masahiro Tsutsumi; Toshihiro Amanuma; Yoshiharu Murata; Dai Nakae; Hiroshi Maruyama; Yuji Kurokawa; Yoichi Konishi
Carcinogenesis, Apr. 1991, [Reviewed] - POSSIBLE INVOLVEMENT OF POLY-ADP-RIBOSYLATION IN PHENOBARBITAL PROMOTION OF RAT HEPATOCARCINOGENESIS
T TSUJIUCHI; M TSUTSUMI; A DENDA; S KONDOH; D NAKAE; H MARUYAMA; Y KONISHI
CARCINOGENESIS, Oct. 1990, [Reviewed] - INFLUENCE OF TIMING OF ADMINISTRATION OF LIPOSOME-ENCAPSULATED SUPEROXIDE-DISMUTASE ON ITS PREVENTION OF ACETAMINOPHEN-INDUCED LIVER-CELL NECROSIS IN RATS
D NAKAE; H YOSHIJI; K YAMAMOTO; H MARUYAMA; T KINUGASA; Y TAKASHIMA; A DENDA; Y KONISHI
ACTA PATHOLOGICA JAPONICA, Aug. 1990, [Reviewed] - LIPOSOME-ENCAPSULATED SUPEROXIDE-DISMUTASE PREVENTS LIVER NECROSIS INDUCED BY ACETAMINOPHEN
D NAKAE; K YAMAMOTO; H YOSHIJI; T KINUGASA; H MARUYAMA; JL FARBER; Y KONISHI
AMERICAN JOURNAL OF PATHOLOGY, Apr. 1990, [Reviewed] - Protective effect of liposome-encapsulated superoxide dismutase on acetaminophen-induced rat hepatocellular necrosis.
YOSHIJI Hitoshi; NAKAE Dai; SHIRAIWA Kazumi; TSUJII Tadasu; KONISHI Yoichi
Kanzo, 1990 - PROTECTIVE EFFECT OF SUPEROXIDE DISMUTASE AGAINST Tert-BUTYLHYDROPEROXIDE CYTOTOXICITY IN CULTURED RAT HEPATOCYTES
Nakae Dai; Yoshiji Hitoshi; Kinugasa Tetsuo; Shiraiwa Kazumi; Konishi Yoichi
J Toxicol Pathol, 1990 - RISK EVALUATION OF ACETAMINOPHEN IN PRE-EXISTING FATTY LIVER INDUCED BY CHOLINE-DEVOID DIET ON LIVER CARCINOGENESIS IN MALE F344 RATS
Takashima Yoshiharu; Maruyama Hiroshi; Kitazawa Shunji; Nakae Dai; Tsutsumi Masahiro; Denda Ayumi; Konishi Yoichi
J Toxicol Pathol, 1990 - Influence of Timing of Administration of Liposome‐encapsulated Superoxide Dismutase on Its Prevention of Acetaminophen‐induced Liver Cell Necrosis in Rats
Dai Nakae; Hitoshi Yoshiji; Kazuhiko Yamamoto; Hiroshi Maruyama; Tetsuo Kinugasa; Yoshinori Takashima; Ayumi Denda; Yoichi Konishi
Pathology International, 1990, [Reviewed] - ENHANCED LIVER METASTATIC POTENTIAL OF ALPHA-FETOPROTEIN-PRODUCING HUMAN GASTRIC-CARCINOMA AFTER CARBON TETRACHLORIDE-INDUCED LIVER-DAMAGE IN NUDE-MICE
H SAWADA; K NAKATANI; N MIYAGI; T NISHIWADA; A WATANABE; T OKUMURA; Y YAMADA; M TSUTSUMI; D NAKAE; H NAKANO; Y KONISHI
JAPANESE JOURNAL OF CANCER RESEARCH, Apr. 1989, [Reviewed] - PEROXIDATION-DEPENDENT AND PEROXIDATION-INDEPENDENT MECHANISMS BY WHICH ACETAMINOPHEN KILLS CULTURED RAT HEPATOCYTES
JL FARBER; TB LEONARD; ME KYLE; D NAKAE; A SERRONI; SA ROGERS
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, Dec. 1988, [Reviewed] - PREVENTIVE EFFECT OF 3-AMINOBENZAMIDE ON THE REDUCTION OF NAD LEVELS IN RAT-LIVER FOLLOWING ADMINISTRATION OF DIETHYLNITROSAMINE
K UCHIDA; S TAKAHASHI; K FUJIWARA; K UEDA; D NAKAE; Y EMI; M TSUTSUMI; K SHIRAIWA; T OHNISHI; Y KONISHI
JAPANESE JOURNAL OF CANCER RESEARCH, Oct. 1988, [Reviewed] - SUPEROXIDE-DISMUTASE AND CATALASE PROTECT CULTURED-HEPATOCYTES FROM THE CYTO-TOXICITY OF ACETAMINOPHEN
ME KYLE; S MICCADEI; D NAKAE; JL FARBER
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 1987, [Reviewed] - STUDIES OF CARCINOGENICITY OF SODIUM-CHLORITE IN B6C3F1 MICE
Y YOKOSE; K UCHIDA; D NAKAE; K SHIRAIWA; K YAMAMOTO; Y KONISHI
ENVIRONMENTAL HEALTH PERSPECTIVES, Dec. 1987, [Reviewed] - Possible Model of Liver Carcinogenesis Using Inhibitors of NAD+ ADP Ribosyl Transferase in Rats
Yoichi Konishi; Sehchi Takahashi; Dai Nakae; Kazuhiko Uchida; Masahiro Tsutsumi; Kazumi Shiraiwa; Ayumi Denda
Toxicologic Pathology, 1986, [Reviewed] - A Case Of Focal Nodular Hyperplasia Of The Liver In A 3 Year-Old Girl
Takashi Yoshikawa; Yasutoshi Fukai; Takahisa Sakurai; Masao Kikukawa; Hideaki Yoshida; Tuneo Shiratori; Yoshihiro Shimano; Yutaka Kinoshita; Hajime öishi; Seiichi Takahashi; Yoko Emi; Dai Nakae; Yoichi Konishi
Kanzo, 1984, [Reviewed] - Carcinogenic effects of 3-di(hydroxymethyl)-amino-6-(5-nitro-2-furylethenyl)-1,2,4-triazine in the small intestine of Ishibashi and Wistar rats
M. Takahashi; S. Nagase; S. Takahashi; Y. Emi; D. Nakae; K. Uchida; Y. Konishi
Experimental Pathology, 1984, [Reviewed] - CARCINOGENIC EFFECTS OF 3-DI(HYDROXYMETHYL)-AMINO-6-(5-NITRO-2-FURYLETHENYL)-1,2,4-TRIAZINE IN THE SMALL-INTESTINE OF ISHIBASHI AND WISTAR RATS
M TAKAHASHI; S NAGASE; S TAKAHASHI; Y EMI; D NAKAE; K UCHIDA; Y KONISHI
EXPERIMENTAL PATHOLOGY, 1984, [Reviewed] - ENHANCEMENT OF DEN INITIATION OF LIVER CARCINOGENESIS BY INHIBITORS OF NAD+ ADP RIBOSYL TRANSFERASE IN RATS
S TAKAHASHI; D NAKAE; Y YOKOSE; Y EMI; A DENDA; S MIKAMI; T OHNISHI; Y KONISHI
CARCINOGENESIS, 1984, [Reviewed] - Distribution and metabolism of N-nitrosobis(2-hydroxypropyl)amine in rats.
Mori Y; Takahashi H; Yamazaki H; Toyoshi K; Obara T; Makino T; Nakae D; Takahashi S; Konishi Y
IARC scientific publications, 1984, [Reviewed]
MISC
- Hepatocarcinogenesis associated with NASH in mice fed a CDAA-HF-T(-) and the involvement of the signal factors
Noriko Kemuriyama; Akari Abe; Megumi Yuki; Kinuko Uno; Sae Nakane; Katsuhiro Miyajima; Dai Nakae
CANCER SCIENCE, Feb. 2022 - A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a cholinedeficient, methionine-lowered, L-amino acid-defined, high-fat diet (vol 19, 251, 2020)
Noriko Suzuki-Kemuriyama; Akari Abe; Kinuko Uno; Shuji Ogawa; Atsushi Watanabe; Ryuhei Sano; Megumi Yuki; Katsuhiro Miyajima; Dai Nakae
LIPIDS IN HEALTH AND DISEASE, Jan. 2022 - Effect of high fat diet on liver in db/db and KK-Ay mice
Mandai K; Miyajima K; Kitamura S; Yamaguchi A; Uno K; Kuroki F; Nishida M; Shirasaka K; Tsustui T; Muro Y; Sugimoto M; Kemuriyama H; Shinohara M; Sasase T; Ohta T; Nakae D
第48回日本毒性学会講演要旨, Jul. 2021 - 2型糖尿病モデルdb/dbおよびKK-Ayマウスの腎臓における高脂肪食摂餌の影響
山口彩音; 美谷島克宏; 宇野絹子; 杉本実紀; 黒木楓子; 西田芽衣; 小郷智記; 煙山紀子; 篠原雅巳; 中江大; 太田毅
The Journal of Toxicological Sciences, Jun. 2020 - Development of an animal hepatocarcinogenesis model through non-obese (Asian-type) nonalcoholic steatohepatitis (NASH)
Noriko Kemuriyama; Satomi Uchino; Syunta Sato; Haruka Funamizu; Linfeng Gao; Kanjiro Ryuu; Kinuko Uno; Soon Hui Teoh; Syuuji Ogawa; Atsushi Watanabe; Katsuhiro Miyajima; Dai Nakae
CANCER SCIENCE, Dec. 2018 - A mouse model of nonalcoholic steatohepatitis using a choline-deficient, methionine-lowered, L-amino acid-defined diet
Noriko Kemuriyama; Kaori Ikehata; Takuya Yamashita; Kinuko Uno; Soon Hui Teoh; Shuji Ogawa; Atsushi Watanabe; Katsuhiro Miyajima; Dai Nakae
CANCER SCIENCE, Jan. 2018 - Responses to the standard for exchange of nonclinical data (SEND) in non-US countries
Takayuki Anzai; Masamichi Kaminishi; Keizo Sato; Laura Kaufman; Hijiri Iwata; Dai Nakae
Journal of Toxicologic Pathology, 01 Apr. 2015, [Reviewed]
Corresponding - Nitric oxide and cancer development
Robert A. Floyd; Yashige Kotake; Rheal A. Towner; We-Xing Guo; Dai Nakae; Yoichi Konishi
Journal of Toxicologic Pathology, 02 Jul. 2007, [Reviewed] - Antioxidant and signal-normalizing properties of phenyl N-tert-butyl nitrone and its derivatives in chemoprevention of hepatocellular carcinoma
D. Nakae; R. A. Floyd
CHEMICO-BIOLOGICAL INTERACTIONS, Jul. 2006
Lead - コリン欠乏アミノ酸(CDAA)食によるマウス肝発がんに対するOgg1遺伝子欠損の修飾効果
傳田阿由美; 中江大; 笹平智則; 木下アンナ; 鰐渕英機; 福島昭治; 國安弘基
日本癌学会学術総会記事, 2006 - S-nitrosylation in the development of choline deficiency-induced hepatocellular carcinoma
WX Guo; RH Broyles; R Towner; K Hensley; D Nakae; Y Kotake; RA Floyd
FREE RADICAL BIOLOGY AND MEDICINE, 2005 - Role of nitric oxide in hepatocellular carcinoma development
RA Floyd; R Towner; WX Guo; K Hensley; RH Broyles; D Nakae; Y Kotake
FREE RADICAL BIOLOGY AND MEDICINE, 2005, [Reviewed] - O-11 Dietary indole-3-carbinol promotes endometrial adenocarcinoma development in rats by increase of cytochrome P450 activities and modulation of estrogen metabolism in the liver(CARCINOGENICITY)(GENERAL SESSION BY ORAL PRESENTATION)(Proceedings of the 31st Annual Meeting)
YOSHIDA Midori; NAKAE Dai; MAEKAWA Akihiko
Journal of toxicological sciences, 29 Oct. 2004 - Existence of a threshold for induction of aberrant crypt foci in the rat colon with low doses of 2-amino-1-methyl-6-phenolimidazo[4,5-b]pyridine
S. Fukushima; H. Wanibuchi; K. Morimura; S. Iwai; D. Nakae; H. Kishida; H. Tsuda; N. Uehara; K. Imaida; T. Shirai; M. Tatematsu; T. Tsukamoto; M. Hirose; F. Furukawa
Toxicological Sciences, Jul. 2004, [Reviewed] - Dietary indole-3-carbinol promotes endometrial adenocarcinoma development in rats by increase of cytochrome P450 activities and modulation of estrogen metabolism in the liver
M Yoshida; D Nakae; A Maekawa
TOXICOLOGY AND APPLIED PHARMACOLOGY, Jun. 2004, [Reviewed] - Inhibitory effect of hydroxymatairesinol on the development of endometrial adenocarcinomas in rats
SI Katsuda; M Yoshida; N Saarinen; A Smeds; D Nakae; R Santti; A Maekawa
TOXICOLOGY AND APPLIED PHARMACOLOGY, Jun. 2004 - Carcinogenic risks in the high-risk groups (SYMPOSIUM3: RECENT TOPICS ON THE RISK ASSESSMENT OF CHEMICAL CARCINOGENS) (Proceedings of the 30th Annual Meeting)
Nakae Dai; Takahashi Masakazu; Yoshida Midori; Uematsu Fumiyuki; Maekawa Akihiko
Journal of toxicological sciences, 31 Oct. 2003 - Effect of neonatal exposure of high dose p-tert octylphenol on the ovary in rats (ENDOCRINE SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
Yoshida Midori; Katashima Sayumi; Maekawa Akihiko; Nakae Dai
Journal of toxicological sciences, 31 Oct. 2003 - Narama, I., Imaida, K., Iwata, H., Nakae, D., Nishikawa, A., Harada, T.: A review of nomenclature and diagnostic criteria for proliferative lesions in the liver of rats by a working group of the Japanese Society of Toxicologic Pathology.
Isao Narama; Katsumi Imaida; Hijiri Iwata; Dai Nakae; Akiyoshi Nishikawa; Takanori Harada
J. Toxicol. Pathol., 2003 - A flow cytometry study on nitric oxide and ROS formation in primary hepatocytes isolated from rats fed with an amino acid diet.
Y Kotake; H Kishida; D Nakae; RA Floyd
FREE RADICAL BIOLOGY AND MEDICINE, 2002 - Dimethylarsinic acid induces 8-hydroxy-2 '-deoxyguanosine formation in the kidney of NCI-Black-Reiter rats
M Vijayaraghavan; H Wanibuchi; R Karim; S Yamamoto; C Masuda; D Nakae; Y Konishi; S Fukushima
CANCER LETTERS, Apr. 2001 - Oncogene c-myc
T. Tsujiuchi; D. Nakae; Y. Konishi
Nippon rinsho. Japanese journal of clinical medicine, 2001 - Decreased expression of Bcl-x protein during hepatocarcinogenesis induced exogenously and endogenously in rats
Yutaka Hatanaka; Dai Nakae; Mamoru Mutai; Kaoru Hashizume; Yuki Kamihara; Noriaki Kinoshita; Yoichi Tani; Gen-Ichi Danno; Shigeo Ohta; Yoichi Konishi; Hitoshi Ashida
Japanese Journal of Cancer Research, 2001 - 有機ヒ素化合物によるラット肝発癌促進作用
鰐渕 英機; 西川 隆之; 魏 民; 木下 アンナ; 中江 大; 小西 陽一; 福島 昭治
日本病理学会会誌, Mar. 2000 - Age and organ dependent spontaneous generation of nuclear 8-hydroxydeoxyguanosine in male Fischer 344 rats
D Nakae; H Akai; H Kishida; O Kusuoka; M Tsutsumi; Y Konishi
LABORATORY INVESTIGATION, Feb. 2000 - Lack of promoting potential of dimethylarsinic acid in the kidney of male NCI-black reiter rats
Meenakshi Vijayaraghavan; Hideki Wanibuchi; Shinji Yamamoto; Katsuo Hakoi; Dai Nakae; Yoichi Konishi; Shoji Fukushima
Journal of Toxicologic Pathology, 2000 - Inhibition by phenyl N-tert-butyl nitrone of early phase hepato-carcinogenesis in rats fed a choline-deficient diet.
Y Kotake; D Nakae; K Kishida; KL Hensely; A Denda; Y Kobayashi; W Kitayama; T Tsujiuchi; H Sang; CA Stewart; T Tabatabie; RA Floyd; Y Konishi
FREE RADICAL BIOLOGY AND MEDICINE, 1998 - Promotion of rat hepatocarcinogenesis by dimethylarsinic acid: Association with elevated ornithine decarboxylase activity and formation of 8-hydroxydeoxyguanosine in the liver
H Wanibuchi; T Hori; Meenakshi, V; T Ichihara; S Yamamoto; Y Yano; S Otani; D Nakae; Y Konishi; S Fukushima
JAPANESE JOURNAL OF CANCER RESEARCH, Dec. 1997 - Preventive effects of various antioxidants on endogenous liver carcinogenesis in rats fed a choline-deficient, L-amino acid-defined diet
NAKAE D.
Food Factors for Cancer Prevention, 1997 - Effects of cell proliferation and cell death (apoptosis and necrosis) on the early stages of rat hepatocarcinogenesis
A Columbano; T Endoh; A Denda; O Noguchi; D Nakae; K Hasegawa; GM LeddaColumbano; AI Zedda; Y Konishi
CARCINOGENESIS, Mar. 1996 - Dose-dependent induction of 8-hydroxyguanine and preneoplastic foci in rat liver by a food-derived carcinogen, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, at low dose levels
T Kato; R Hasegawa; D Nakae; M Hirose; M Yaono; L Cui; Y Kobayashi; Y Konishi; N Ito; T Shirai
JAPANESE JOURNAL OF CANCER RESEARCH, Feb. 1996 - A CASE OF EARLY GASTRIC MALIGNANT-LYMPHOMA DIAGNOSED AND COMPLETELY RESECTED BY STRIP BIOPSY
Y MORIMOTO; S KURIYAMA; H YOSHIJI; M MATSUMOTO; K MASUI; T SAKAMOTO; H KOJIMA; M YOSHIKAWA; H FUKUI; D NAKAE; Y KONISHI; M UENO; H NAKANO; T TSUJII
JOURNAL OF GASTROENTEROLOGY, Apr. 1995 - PRIMARY ANGIOSARCOMA OF THE HEART : AN AUTOPSY CASE REPORT WITH IMMUNOHISTOCHEMICAL OBSERVATIONS
Maruyama Hiroshi; Yokose Yoshihiko; Kobayashi Eisaku; Endo Takehiro; Tsujiuchi Toshifumi; Tsutsumi Masahiro; Nakae Dai; Nishimine Kiyoshi; Kitamura Soichiro; Konishi Yoichi
奈良医学雑誌, 28 Feb. 1995 - Effects of oxidative stress induced by redox-enzyme modulation on rat hepatocarcinogenesis
Ayumi Denda; Takehiro Endoh; Dai Nakae; Yoichi Konishi
Toxicology Letters, 1995 - ENHANCEMENT BY ORGANOSULFUR COMPOUNDS FROM GARLIC AND ONIONS OF DIETHYLNITROSAMINE-INDUCED GLUTATHIONE-S-TRANSFERASE POSITIVE FOCI IN THE RAT-LIVER
N TAKADA; T MATSUDA; T OTOSHI; Y YANO; S OTANI; T HASEGAWA; D NAKAE; Y KONISHI; S FUKUSHIMA
CANCER RESEARCH, Jun. 1994 - SPONTANEOUS PASSAGE OF A COLON CAST IN THE ABSENCE OF ABDOMINAL ANEURYSM
H YOSHIJI; D NAKAE; R SUGIYA; Y MIZUMOTO; M TSUTSUMI; K HIRIGUCHI; Y YOKOSE; R SAKURAI; H FUKUI; T TSUJII; Y KONISHI
JOURNAL OF GASTROENTEROLOGY, Feb. 1994 - HIGH-INCIDENCE OF HEPATOCELLULAR CARCINOMAS INDUCED BY A CHOLINE-DEFICIENT L-AMINO-ACID DEFINED DIET IN RATS
D NAKAE; H YOSHIJI; Y MIZUMOTO; K HORIGUCHI; K SHIRAIWA; K TAMURA; A DENDA; Y KONISHI
CANCER RESEARCH, Sep. 1992 - INHIBITORY EFFECT OF DIETARY IRON-DEFICIENCY ON INDUCTIONS OF PUTATIVE PRENEOPLASTIC LESIONS AS WELL AS 8-HYDROXYDEOXYGUANOSINE IN DNA AND LIPID-PEROXIDATION IN THE LIVERS OF RATS CAUSED BY EXPOSURE TO A CHOLINE-DEFICIENT L-AMINO-ACID DEFINED DIET
H YOSHIJI; D NAKAE; Y MIZUMOTO; K HORIGUCHI; K TAMURA; A DENDA; T TSUJII; Y KONISHI
CARCINOGENESIS, Jul. 1992 - PRODUCTION OF BOTH 8-HYDROXYDEOXYGUANOSINE IN LIVER DNA AND GAMMA-GLUTAMYLTRANSFERASE-POSITIVE HEPATOCELLULAR LESIONS IN RATS GIVEN A CHOLINE-DEFICIENT, L-AMINO ACID-DEFINED DIET
D NAKAE; H YOSHIJI; H MARUYAMA; T KINUGASA; A DENDA; Y KONISHI
JAPANESE JOURNAL OF CANCER RESEARCH, Nov. 1990 - ENDOCYTOSIS-INDEPENDENT UPTAKE OF LIPOSOME-ENCAPSULATED SUPEROXIDE-DISMUTASE PREVENTS THE KILLING OF CULTURED-HEPATOCYTES BY TERT-BUTYL HYDROPEROXIDE
D NAKAE; H YOSHIJI; T AMANUMA; T KINUGASA; JL FARBER; Y KONISHI
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, Jun. 1990 - LACK OF HEPATOCARCINOGENIC POTENTIAL OF ACETAMINOPHEN IN RATS WITH LIVER-DAMAGE ASSOCIATED WITH A CHOLINE-DEVOID DIET
H MARUYAMA; Y TAKASHIMA; Y MURATA; D NAKAE; H EIMOTO; M TSUTSUMI; A DENDA; Y KONISHI
CARCINOGENESIS, Jun. 1990 - PERSISTENT EFFECT OF A LOW-DOSE OF PREADMINISTERED DIETHYLNITROSAMINE ON THE INDUCTION OF ENZYME-ALTERED FOCI IN RAT-LIVER
S TAKAHASHI; M TSUTSUMI; D NAKAE; A DENDA; T KINUGASA; Y KONISHI
CARCINOGENESIS, Apr. 1987 - ROLE OF POLY ADP-RIBOSYRATION REACTION ON THE INDUCTION OF GAMMA-GTP POSITIVE FOCI IN RAT-LIVER
S TAKAHASHI; K UCHIDA; D NAKAE; Y KONISHI; T OHNISHI
JOURNAL OF RADIATION RESEARCH, 1985 - INVOLVEMENT OF POLY-ADP RIBOSYLATION IN THE INDUCTION OF HYPERPLASTIC NODULES IN RAT-LIVER INITIATED BY DIETHYLNITROSAMINE (DEN)
Y KONISHI; S TAKAHASHI; D NAKAE; K UCHIDA; H MARUYAMA; Y YOKOSE; Y EMI; T OBARA; T MAKINO; A DENDA
PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1984
Books and other publications
Lectures, oral presentations, etc.
Research Themes
- Study on the Mechanisms Underlying Endogenous Hepatocarcinogenesis Induced Only by the Manipulation of Food Composition
Grant-in-Aid for Scientific Research (C)
Sasaki Institute, Sasaki Foundation
2004 - 2005 - Risk Assessment of Carcinogenesis due to Environmental Agents
Grant-in-Aid for Scientific Research on Priority Areas
Osaka City University Medical School
1996 - 1999 - Basic Research on the Development and Progression of Pancreatic Duct Adenocarcinoma
Grant-in-Aid for Scientific Research (A)
Nara Medical University
1996 - 1999
Media Coverage
■University education and qualification information
Qualifications, licenses
- License for Medical Doctor
- Qualified M.D. to Perform Pathological Autopsy
- Diplomate of the Japanese Society of Toxicologic Pathology
- Certified Pathologist of The Japanese Society of Pathology
- Fellow of the International Academy of Toxicologic Pathology
- Instructor for Certified Pathologist of the Japanese Society of Pathology
- Occupational Physician Certified by the Japan Medical Association
- Board Certified Physician and Supervisory Physician for Public Health and Social Medicine
- Board-Certified Doctor of Pathology
- Expert of Cancer Prevention
