Masayoshi Koinuma

Faculty of Pharmaceutical Sciences,Department of Pharmaceutical SciencesProfessor
Graduate School of Pharmaceutical Sciences,Doctoral Program in Pharmaceutical SciencesProfessor
Last Updated :2025/10/31

■Researcher basic information

Degree

  • Doctor of Philosophy in Pharmacology, Nihon University

Field Of Study

  • Life sciences, Clinical pharmacy
  • Informatics, Statistical science
  • Life sciences, Healthcare management, medical sociology
  • Life sciences, Clinical pharmacy

■Career

Career

  • Apr. 2024 - Present
    University of Fukui
  • Apr. 2021 - Present
    Japan University of Economics, Professor
  • Apr. 2020 - Present
  • Sep. 2013 - Present
    Teikyo Heisei University, Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences
  • Nov. 2020 - Mar. 2025
  • Apr. 2019 - Mar. 2025
    Shinshu University, Shinshu University Hospital Center for Clinical Research
  • Jul. 2015 - Mar. 2019
    Shinshu University, Shinshu University Hospital Center for Clinical Research
  • 2011 - Aug. 2013
    Nihon Univ, School of Pharmacy Department of Pharmacy, Associate Professor
  • 2009 - 2010
    Nihon Univ, School of Pharmacy Department of Pharmacy, Associate Professor
  • 2005 - 2008
    Nihon Univ, School of Pharmacy Department of Pharmacy
  • 2000 - 2004
  • 1997 - 2004
    Nippon Medical School
  • 1993 - 1996
    Nippon Medical School

Member History

  • Oct. 2023 - Present
  • Sep. 2023 - Present
  • Dec. 2022 - Present
  • Sep. 2022 - Present
  • Jun. 2022 - Present
  • Mar. 2021 - Present
  • Apr. 2018 - Present
  • Apr. 2018 - Present
  • Apr. 2017 - Present
  • 2016 - Present
  • Apr. 2015 - Present
  • Jan. 2015 - Present
  • Jun. 2013 - Present
  • Apr. 2013 - Present
  • 2010 - Present
    Pharmaceutical Affairs Department
  • Jun. 2012 - Mar. 2018

■Research activity information

Award

  • Jul. 2025
  • May 2025
    Taiwan Healthcare Industry Balanced Scorecard Management Association, Poster Presentation Award
    Strategic Management in Healthcare: The International Positioning of the Balanced Scorecard (BSC) in Japan, Taiwan, Province of China, International society
    Masayoshi Koinuma;Tomohide Akase
  • Jun. 2022
  • May 2022
  • Nov. 2021
  • Oct. 2018
  • Sep. 2014
  • Nov. 2013
  • Aug. 2013
  • Dec. 2012
  • Sep. 2004
    Japan

Paper

  • Exploratory Investigation of Predictive Factors for Reducing Adverse Effects in CapeOX Therapy for Colorectal Cancer Patients
    Makoto Kishimoto; Masayoshi Koinuma; Jin Tokunaga
    Cureus, 29 Oct. 2025, [Reviewed]
    URLDOI URL
  • Letter to the editor: Early adversity and inflammation at midlife: the moderating role of internalizing psychopathology
    Hisao Toyoshima; Masayoshi Koinuma; Tomohide Akase
    Psychological Medicine, 29 Aug. 2025, [Reviewed]
    URLDOI URL
  • Factors which affect Place of Death in Home Medical Care including Medical Resource Consumption, Nursing Care Level, and Disease
    Okamoto Y.; Koinuma M.; Iriuchijima R.; Akase T.; Ara T.; Fukuda S.; Yamaguchi T.
    International Journal of Case Reports and Clinical Images, Aug. 2025, [Reviewed], [Invited]
  • Association Between Suicide and Physical Illness in Japan: An Analysis Using Statistical Adjustment Based on Regional Attributes
    Akihito Ueda; Masayoshi Koinuma
    Cureus, 13 Apr. 2025, [Reviewed]
    URLDOI URL
  • Sensory Evaluation of Dosage Form Preference of Oral Rehydration Solutions for Mucositis and Diarrhea Associated with Cancer Treatment　　　　　　　　　　　　　　　
    Kumi Nakamura; Toshihide Onikubo; Masayoshi Koinuma
    Apr. 2025, [Reviewed]
  • Survey of Specialist Pharmacy Accreditation Status and Medical Cooperation at Establishment of Specialized Medical Institution Cooperation Pharmacy System　　　　　　　　　　　　　　　
    Mika Naganuma; Eiji Shimanuki; Atsuko Matsumura; Hitoshi Suzuki; Mizuomi Yasaka; Sunao Makihara; Masayoshi Koinuma; Naoki Kondo
    Journal of Japanese Society of Pharmaceutical Oncology, Feb. 2025, [Reviewed]
  • Factors which affect place of death in home medical care including medical resource consumption, nursing care level, and disease.
    Yoshihisa Okamoto; Masayoshi Koinuma; Reiko Iruchijima; Takano Ara; Shunichi Fukuda; Takahide Yamaguchi; Tomohide Akase
    29 Nov. 2024, [Reviewed]
    DOI URL
  • Feasibility of Using the Japanese version of the Mental Health Continuum Short Form (MHC-SF-J) as an Evaluation Scale for Electronic Patient-Reported Outcomes in Patients with Inflammatory Bowel Disease　　　　　　　　　　　　　　　
    Hisao Toyoshima; Masayoshi Koinuma; Shin Hirosaki; Tomohide Akase
    Japanese Journal of Applied IT Healthcare, Oct. 2024, [Reviewed]
  • Points to Consider When Creating a Procedure to Deliver Investigational Medical Products to Trial Participants
    Naoki KONDO; Tatsuya WATANABE; Natsuko OIMOTO; Satoshi KURODA; Masako TSURUMARU; Nao MORIYAMA; Emiko FUKAGAWA; Mitsuo KIMATA; Hisako KOBAYASHI; Shinya TAMAKI; Masaaki JITSU; Yusuke FUKUDA; Masayoshi KOINUMA
    Japanese Journal of Clinical Pharmacology and Therapeutics, 31 Jul. 2024, [Reviewed]
    URLDOI URL
  • Exploring factors associated with bleeding events after open heart surgery in patients on dialysis − effects of the presence or absence of warfarin therapy
    Masanori Suzuki; Yuki Hasegawa; Hiroaki Tanabe; Masayoshi Koinuma; Ryohkan Funakoshi
    Journal of Pharmaceutical Health Care and Sciences, 12 Jul. 2024, [Reviewed]
    Abstract

    Background

    Perioperative management of patients on dialysis is critical for controlling bleeding and thrombotic risk, in addition to infection control. Postoperative anticoagulation is often difficult to control, and different institutions have different policies. Therefore, in this study, we aimed to investigate factors associated with postoperative bleeding events and whether warfarin (WF) therapy affects the incidence of postoperative bleeding events, total mortality, and stroke.

    Methods

    Patients who were admitted to the cardiovascular surgery department and underwent valve replacement or plasty were included, and those who underwent mechanical valve introduction were excluded. Thirty-nine patients were included in the study. The primary endpoint was to identify factors associated with the composite endpoint of postoperative bleeding events, and the secondary endpoint was to determine the effect size of WF therapy on postoperative bleeding events, all-cause mortality, and stroke and the strength of association between the crossed endpoints. The strength of the association between the crossed items was examined.

    Results

    Low body weight (p = 0.038) was identified as a factor associated with the primary endpoint of postoperative bleeding events. The secondary endpoint of whether or not patients received WF therapy was largely unrelated to bleeding events, all-cause mortality, and postoperative stroke up to 90 days after surgery.

    Conclusions

    Preliminary studies suggest that low body weight is a risk factor for postoperative bleeding events in patients on dialysis, although further exploration of other factors will be necessary with the accumulation of similar cases.
    URLDOI URL
  • Reduction in short interval intracortical inhibition from the early stage reflects the pathophysiology in amyotrophic lateral sclerosis: A meta-analysis study.
    Mana Higashihara; Nathan Pavey; Parvathi Menon; Mehdi van den Bos; Kazumoto Shibuya; Satoshi Kuwabara; Matthew C Kiernan; Masayoshi Koinuma; Steve Vucic
    European journal of neurology, 20 Mar. 2024, [Reviewed]
    BACKGROUND AND PURPOSE: Cortical hyperexcitability has been identified as a diagnostic and pathogenic biomarker of amyotrophic lateral sclerosis (ALS). Cortical excitability is assessed by transcranial magnetic stimulation (TMS), a non-invasive neurophysiological technique. The TMS biomarkers exhibiting highest sensitivity for cortical hyperexcitability in ALS remain to be elucidated. A meta-analysis was performed to determine the TMS biomarkers exhibiting the highest sensitivity for cortical hyperexcitability in ALS. METHODS: A systematic literature review was conducted of all relevant studies published in the English language by searching PubMed, MEDLINE, Embase and Scopus electronic databases from 1 January 2006 to 28 February 2023. Inclusion criteria included studies reporting the utility of threshold tracking TMS (serial ascending method) in ALS and controls. RESULTS: In total, more than 2500 participants, incorporating 1530 ALS patients and 1102 controls (healthy, 907; neuromuscular, 195) were assessed with threshold tracking TMS across 25 studies. Significant reduction of mean short interval intracortical inhibition (interstimulus interval 1-7 ms) exhibited the highest standardized mean difference with moderate heterogeneity (-0.994, 95% confidence interval -1.12 to -0.873, p < 0.001; Q = 38.61, p < 0.05; I2  = 40%). The reduction of cortical silent period duration along with an increase in motor evoked potential amplitude and intracortical facilitation also exhibited significant, albeit smaller, standardized mean differences. CONCLUSION: This large meta-analysis study disclosed that mean short interval intracortical inhibition reduction exhibited the highest sensitivity for cortical hyperexcitability in ALS. Combined findings from this meta-analysis suggest that research strategies aimed at understanding the cause of inhibitory interneuronal circuit dysfunction could enhance understanding of ALS pathogenesis.
    DOI URL
  • Impact of Prefracture Cognitive Impairment and Postoperative Delirium on Recovery after Hip Fracture Surgery.
    Tomoko Kamimura; Yuya Kobayashi; Satoshi Tamaki; Masayoshi Koinuma
    Journal of the American Medical Directors Association, 28 Feb. 2024, [Reviewed]
    OBJECTIVES: This study aimed to examine the impact of prefracture cognitive impairment (CI) severity and postoperative delirium on recovery after hip fracture surgery in older patients. DESIGN: Prospective study with a 1-year follow-up. SETTING AND PARTICIPANTS: We included 355 patients aged ≥80 years from 2 acute hospitals in Japan. METHODS: Barthel Index (BI) ambulation scores were assessed prefracture and at 1, 3, 6, and 12 months postoperatively. The score at each time point minus the prefracture score was used as the ambulation recovery variable. The 21-item Dementia Assessment Sheet for the Community-based Care System (DASC-21) and Confusion Assessment Method were used to assess CI severity and delirium, respectively. The impacts of CI severity and delirium on recovery at 1 month and by 12 months postoperatively were examined. Linear multiple regression and linear mixed effects models were used. RESULTS: BI ambulation scores remained the same or improved from prefracture levels in 26.8%, 34.4%, 33.0%, and 30.4% of patients at 1, 3, 6, and 12 months, respectively. Ten patients (2.8%) had fall-related hip fractures, 20 (5.6%) were rehospitalized, and 43 (12.1%) died during this period. Although DASC-21 CI severity significantly affected the recovery both at 1 month and by 12 months postoperatively [standardized β (Stdβ) = -0.39, P < .0001, and Stdβ = -0.37, P < .0001, respectively], delirium did not. Other variables affecting recovery by 12 months postoperatively included prefracture BI ambulation scores, Mini Mental State Examination scores, age, fracture type, place of residence, and time. CONCLUSIONS AND IMPLICATIONS: Postoperative ambulation recovery, excluding the effect of death and other poor outcomes, is influenced by prefracture CI severity, and the presence of delirium itself may not be the moderating variable. These results emphasize the importance of treatment planning based on prefracture CI severity and indicate that assessments such as the DASC-21 may be useful in implementing such a plan.
    DOI URL
  • 問題解決型意識調杏を用いた院内フォーミュラリー 推進のための行動計画の策定に関する研究　　　　　　　　　　　　　　　
    Sep. 2023, [Reviewed]
  • Evaluation of the relationship between pregnant/postpartum women’s characteristics and pharmacy use experience in terms of consultation needs with pharmacists Ikeshita A, Sagara A, Azechi T, Maeda-Minami A, Sato K, Kominato H, Torigoe K, Sano M, Horiuchi M, Sato F, Arita E, Yumoto T, Koinuma M　　　　　　　　　　　　　　　
    Ikeshita A; Sagara A; Azechi T; Maeda-Minami A; Sato K; Kominato H; Torigoe K; Sano M; Horiuchi M; Sato F; Arita E; Yumoto T; Koinuma M
    Journal of Pharmaceutical Communication, Apr. 2023, [Reviewed]
  • Efficacy and Safety of Low-dose Spironolactone for Chronic Kidney Disease in Type 2 Diabetes
    Ako Oiwa; Dai Hiwatashi; Teiji Takeda; Takahide Miyamoto; Iori Kawata; Masayoshi Koinuma; Masanori Yamazaki; Mitsuhisa Komatsu
    The Journal of Clinical Endocrinology & Metabolism, 14 Mar. 2023, [Reviewed]
    Abstract

    Context

    Although adding spironolactone to renin-angiotensin system blockers reduces albuminuria in adults with chronic kidney disease and type 2 diabetes, it increases the risk of hyperkalemia.

    Objective

    To assess whether a lower dose of spironolactone (12.5 mg/d) reduces the risk of hyperkalemia while maintaining its effect on reducing albuminemia.

    Design

    Multicenter, open-label, randomized controlled trial.

    Setting

    This study was conducted from July 2016 to November 2020 in ambulatory care at 3 diabetes medical institutions in Japan.

    Patients

    We enrolled 130 Japanese adults with type 2 diabetes and albuminuria (≥30 mg/gCre), estimated glomerular filtration rate ≥30 mL/min/1.73 m2, and serum potassium level &lt;5.0 mEq/L.

    Interventions

    The participants were randomly assigned to the spironolactone-administered and control groups.

    Main outcome measures

    Changes in urine albumin-to-creatinine ratio (UACR) from baseline over the 24-week interventional period.

    Results

    The spironolactone group showed a significant reduction in UACR from baseline (mean decrease, 103.47 ± 340.80 mg/gCre) compared with the control group, which showed an increased UACR (mean increase, 63.93 ± 310.14 mg/gCre; P = .0007, Wilcoxon rank-sum test and t test). Although the spironolactone group had a statistically significant increase in serum potassium levels, none of the participants had a potassium level ≥5.5 mEq/L at 24 weeks. Further, participants with a higher initial serum potassium level tended to have a smaller increase (estimate, −0.37, analysis of covariance).

    Conclusions

    Low-dose spironolactone administration reduced albuminuria without causing hyperkalemia. Spironolactone administration, the oldest known and most cost-effective mineralocorticoid receptor antagonist, at lower doses should be reconsidered.
    URLDOI URL
  • A case-series research of EGFR mutation and its effect on the cost of chemotherapy in non-small cell lung cancer（NSCLC）　　　　　　　　　　　　　　　
    YOSHIHISA OKAMOTO; MASAYOSHI KOINUMA; REIKO IRIUCHIJIMA; MICHIHIRO KAYA; TOMOHIDE AKASE
    The Bulletin of the Graduate School of Business, Mar. 2023, [Reviewed]
  • T-cell Response and Antibody Production by Booster COVID-19 Vaccination in Japanese Patients with Chronic Kidney Disease Treated with Hemodialysis
    Ayumi Yoshifuji; Masataro Toda; Munekazu Ryuzaki; Kan Kikuchi; Toru Kawai; Ken Sakai; Emi Oyama; Masayoshi Koinuma; Kazuhiko Katayama; Yuki Uehara; Norio Ohmagari; Yoshihiko Kanno; Hirofumi Kon; Toshio Shinoda; Yaoko Takano; Junko Tanaka; Kazuhiko Hora; Yasushi Nakazawa; Naoki Hasegawa; Norio Hanafusa; Fumihiko Hinoshita; Keita Morikane; Shu Wakino; Hidetomo Nakamoto; Yoshiaki Takemoto
    Vaccines, Mar. 2023, [Reviewed]
    DOI URL
  • Is using a consolidation tumor ratio 0.5 as criterion feasible in daily practice? Evaluation of interobserver measurement variability of consolidation tumor ratio of lung cancer less than 3 cm in size.
    Sachie Koike; Kimihiro Shimizu; Shogo Ide; Shuji Mishima; Shunichiro Matsuoka; Tetsu Takeda; Kentaro Miura; Takashi Eguchi; Kazutoshi Hamanaka; Taisuke Araki; Kei Sonehara; Keisuke Todoroki; Fumihito Ichinohe; Satoshi Kawakami; Masayoshi Koinuma
    Thoracic cancer, 03 Oct. 2022, [Reviewed]
    BACKGROUND: Consolidation tumor ratio (CTR) calculated as the ratio of the tumor consolidation diameter to the tumor maximum diameter on thin-section computed tomography (CT) of lung cancer has been reported as an important prognostic factor. It has also been used for treatment decision-making. This study aimed to investigate the interobserver variability of CTR measurements on preoperative CT and propose a clinically useful CTR-based classification criterion. METHODS: We enrolled 119 patients who underwent surgery for suspected or diagnosed small-sized lung cancer (≤3.0 cm in diameter). Nine doctors reviewed preoperative CT scans to measure CTR. Interobserver variability of CTR measurements was evaluated using the coefficient of variation (CV) and Fleiss' κ. The prognostic effect of the CTR-based classification was assessed using the Kaplan-Meier method. RESULTS: Interobserver variability of CTR measurement was the highest for tumors with the lowest CTR (CTR = 0); it decreased as CTR increased and reached a plateaued level of low variability (CV <0.5) at CTR of 0.5. We proposed a three-group classification based on the findings of CTR interobserver variability (CTR < 0.5, 0.5 ≤ CTR < 1, and CTR = 1). Interobserver agreement of the judgment of the CTR-based classification was excellent (Fleiss' κ = 0.81). The classification significantly stratified patient prognosis (p < 0.001, 5-year overall survival rates with CTR < 0.5, 0.5 ≤ CTR < 1, and CTR = 1 were 100, 88, and 73.8%, respectively). CONCLUSIONS: CTR 0.5 is a clinically relevant and helpful cutoff for treatment decision-making in patients with early-stage lung cancer based on high interobserver agreement and good prognostic stratification.
    DOI URL
  • Investigation for the efficacy of COVID-19 vaccine in Japanese CKD patients treated with hemodialysis.
    Ayumi Yoshifuji; Masataro Toda; Munekazu Ryuzaki; Kan Kikuchi; Toru Kawai; Ken Sakai; Emi Oyama; Masayoshi Koinuma; Kazuhiko Katayama; Yuki Uehara; Norio Ohmagari; Yoshihiko Kanno; Hirofumi Kon; Toshio Shinoda; Yaoko Takano; Junko Tanaka; Kazuhiko Hora; Yasushi Nakazawa; Naoki Hasegawa; Norio Hanafusa; Fumihiko Hinoshita; Keita Morikane; Shu Wakino; Hidetomo Nakamoto; Yoshiaki Takemoto
    Renal replacement therapy, Aug. 2022, [Reviewed]
    Background: Dialysis patients are predisposed to severe disease and have a high mortality rate in coronavirus disease 2019 (COVID-19) due to their comorbidities and immunocompromised conditions. Therefore, dialysis patients should be prioritized for vaccination. This study aimed to examine how long the effects of the vaccine are maintained and what factors affect antibody titers. Methods: Hemodialysis patients (HD group) and age- and sex-matched non-dialysis individuals (Control group), receiving two doses of BNT162b2 vaccine, were recruited through the Japanese Society for Dialysis Therapy (JSDT) Web site in July 2021. Anti-SARS-CoV-2 immunoglobulin (IgG) (SARS-CoV-2 IgG titers) was measured before vaccination, 3 weeks after the first vaccination, 2 weeks after the second vaccination, and 3 months after the second vaccination, and was compared between Control group and HD group. Factors affecting SARS-CoV-2 IgG titers were also examined using multivariable regression analysis and stepwise regression analysis (least AIC). In addition, we compared adverse reactions in Control and HD groups and examined the relationship between adverse reactions and SARS-CoV-2 IgG titers. Results: Our study enrolled 123 participants in the Control group (62.6% men, median age 67.0 years) and 206 patients in the HD group (64.1% men, median age 66.4 years). HD group had significantly lower SARS-CoV-2 IgG titers at 3 weeks after the first vaccination (p < 0.0001), 2 weeks after second vaccination (p = 0.0002), and 3 months after the second vaccination (p = 0.045) than Control group. However, the reduction rate of SARS-CoV-2 IgG titers between 2 weeks and 3 months after the second vaccination was significantly smaller in HD group than in Control (p = 0.048). Stepwise regression analysis revealed that dialysis time was identified as the significant independent factors for SARS-CoV-2 IgG titers at 2 weeks after the second vaccination in HD group (p = 0.002) and longer dialysis time resulted in higher maximum antibody titers. The incidences of fever and nausea after the second vaccination were significantly higher in the HD group (p = 0.039 and p = 0.020). Antibody titers in those with fever were significantly higher than those without fever in both groups (HD: p = 0.0383, Control: p = 0.0096). Conclusion: HD patients had significantly lower antibody titers than age- and sex-matched non-dialysis individuals over 3 months after vaccination. Dialysis time was identified as a factor affecting SARS-CoV-2 IgG titers in HD group, with longer dialysis time resulting in higher maximum SARS-CoV-2 IgG titers.
    DOI URL
  • Survey of pregnant/postpartum women’s ease of consultation with pharmacists and self-reporting their pregnant/postpartum status　　　　　　　　　　　　　　　
    Akito Ikeshita; Atsunobu Sagara; Takuya Azechi; Ayako Maeda-Minami; Kayoko Sato; Masayoshi Koinuma; Hidenori Kominato; Kazuhiro Torigoe; Motohiko Sano; Masako Horiuchi; Fumiaki Sato; Etsuko Arita; Tetsuro Yumoto
    Journal of the Pharmaceutical Communication Society of Japan, Apr. 2022, [Reviewed]
  • Factors associated with SARS-CoV-2 antibody titers and prognosis of breakthrough infection in hemodialysis patients.
    Masataro Toda; Ayumi Yoshifuji; Kan Kikuchi; Masayoshi Koinuma; Motoaki Komatsu; Kentaro Fujii; Ai Kato; Takahide Kikuchi; Atsushi Nakazawa; Munekazu Ryuzaki
    Clinical and experimental nephrology, 08 Feb. 2022, [Reviewed]
    BACKGROUND: The mortality rate of Coronavirus disease 2019 (COVID-19) is extremely high in hemodialysis patients (HDP). These patients also develop lower antibody titers after vaccination. Therefore, factors associated with antibody titers and vaccine efficacy in HDP with breakthrough infection need to be investigated. METHODS: We measured anti-S1 antibody titers in HDP (n = 104) and controls (n = 35), evaluating the influence of background on HDP by multivariable regression analysis. We classified 26 HDP patients admitted with COVID-19 into the unvaccinated (n = 15) and breakthrough infection group (n = 11), performing between-group comparisons of laboratory findings and prognosis. Vaccinated COVID-19 patients were classified into HDP and non-HDP controls, and compared the relationship between antibody titer and severity, and the prognosis of breakthrough infection. RESULTS: The antibody titer was significantly lower in the HDP group than in the control group. Among HDP, age and smoking history were significantly independent factors associated with antibody titer. The breakthrough infection group had significantly better laboratory findings (KL-6 and LDH), severity, and hospitalization period than the unvaccinated group even if antibody titers were lower than the known threshold for neutralization (p < 0.05). There was no significant difference in prognosis between the HDP and non-HDP with breakthrough infection. Severity of COVID-19 tended to be higher with lower antibody titer in non-HDP, but not in HDP. CONCLUSION: Vaccines improved the severity of COVID-19 and hospitalization period of breakthrough infection in HDP, although HDP, especially in elderly smokers had lower antibody titers than control. There was no significant association between antibody titer and severity in HDP.
    DOI URL
  • Prescription pattern analysis for antibiotics in working-age workers diagnosed with common cold.
    Yasuhiro Araki; Kenji Momo; Takeo Yasu; Kohtaro Ono; Takeshi Uchikura; Masayoshi Koinuma; Tadanori Sasaki
    Scientific reports, 22 Nov. 2021, [Reviewed]
    Antimicrobial resistance is a major health concern. A primary cause is the inappropriate use of antimicrobials, particularly by patients with upper respiratory tract infection. However, baseline information for antibiotic use for common cold before being applied the National Action Plan on Antimicrobial Resistance in Japan is lacking. Here, we analyzed the inappropriate use of antibiotics in the working-age workers. We used large claims data from an annual health check-up for at least 5 consecutive years. Among 201,223 participants, we included 18,659 working-age workers who were diagnosed with common cold at a clinic/hospital. We calculated the proportion of patients with common cold who were prescribed antibiotics and analyzed predictive factors associated with antibiotics prescription. Antibiotics were prescribed to 49.2% (n = 9180) of patients diagnosed with common cold. In the logistic regression analysis, the group taking antibiotics was predominantly younger, male, without chronic diseases, and diagnosed at a small hospital/clinic (where the number of beds was 0-19). Cephems accounted for the highest proportion of prescribed antibiotics, with 40-45% of patients being prescribed antibiotics. Our data may be applied to prioritize resources such as medical staff-intervention or education of working-age people without chronic diseases who visit clinics for common cold to avoid the potential inappropriate use of antibiotics and prevent antimicrobial resistance acceleration.
    DOI URL
  • Survey of patients’ families’ views on polypharmacy in home medical care and factors related to patient status
    清水一郎; 福田俊一; 土器潔; 柳田毅; 岡本敬久; 濃沼政美; 赤瀬朋秀; 山口高秀
    日本在宅医療連合学会誌(Web), Sep. 2021, [Reviewed]
  • Exploratory research on asthma exacerbation risk factors using the Japanese claims database and machine learning: a retrospective cohort study
    Soichiro Hozawa; Shotaro Maeda; Akira Kikuchi; Masayoshi Koinuma
    Journal of Asthma, 18 May 2021, [Reviewed]
    DOI URL
  • Cut-off values of serum IgG4 among three reagents, including a novel IgG4 reagent: a multicenter study.
    Yoko Usami; Mitsutoshi Sugano; Takeshi Uehara; Masayoshi Koinuma; Nau Ishimine; Kenji Kawasaki; Kazuyoshi Yamauchi; Hideaki Hamano; Takayuki Honda
    Scientific reports, 31 Mar. 2021, [Reviewed]
    DOI URL
  • Relationship between Low Pretreatment Geriatric Nutritional Risk Index and Poor Tolerability of Azacitidine in Patients with Myelodysplastic Syndromes.
    Dan Kanehira; Masayoshi Koinuma; Toshiaki Kato; Tomoya Abe; Atsunobu Sagara; Fumiaki Sato; Tetsuro Yumoto
    Annals of nutrition & metabolism, 04 Mar. 2021, [Reviewed]
    DOI URL
  • Convergent validity of a simplified device and relationship between blood lactate and salivary lactate after a vertical squat jump in healthy non-athletes.
    Satomi Okano; Hitomi Nishizawa; Joya Yui; Yoshiharu Yokokawa; Masayoshi Koinuma; Akinori Nakamura
    Journal of physical therapy science, Mar. 2021, [Reviewed]
    [Purpose] The aims of this study were 1) to examine the convergent validity between Lactate pro 2 and a standard JCA-BM 8000 automatic analyzer using salivary lactate and 2) to investigate the relationship between blood and salivary lactate levels after a vertical squat jump. [Participants and Methods] Healthy non-athletes participated in this observational study. The participants performed a vertical squat jump for 1 min 30 s. Blood and salivary lactate levels were measured before and after exercise using Lactate Pro 2. [Results] The intraclass correlation coefficient between Lactate Pro 2 and the JCA-BM 8000 automatic analyzer was 0.773, which can be considered as substantial convergent validity. However, in some samples, the salivary lactate level was out of the measurable range, and numerical values could not be obtained. The cross-correlation function between the blood and salivary lactate levels was 0.535 at lag 0 and 0.750 at lag 1, which indicated a 5-min lag between the salivary and blood lactate values. [Conclusion] Salivary lactate levels can be easily measured using Lactate Pro 2, although its sensitivity needs to be resolved. Further research is required for salivary lactate level, which can be collected non-invasively, to be used as an alternative parameter to blood lactate level.
    DOI URL
  • Predictive factors associated with bleeding in atrial fibrillation patients treated with anti-coagulant drugs using a large claims database
    Kenji Momo; Kana Shu-toh; Makiko Kaneko; Nauta Yamanaka; Yuji Oto; Katsumi Tanaka; Masayoshi Koinuma; Tadanori Sasaki
    PLOS ONE, Aug. 2020, [Reviewed]
    DOI URL
  • Analysis of factors involved in the reduction and maintenance of HbA1c at the outpatient clinic of the regional cooperation critical pathway for diabetes mellitus
    池滝晶子; 赤木祐貴; 小井土啓一; 濃沼政美; 宇治原誠
    日本クリニカルパス学会誌, Jul. 2020, [Reviewed]
    URL
  • 医師・薬剤師が消費者として花粉症治療薬に求める特徴について コンジョイント分析を用いた統計学的検討
    Apr. 2020, [Reviewed]
  • Pharmacological considerations in antipsychotic drug selection for prevention of drug-induced dysphagia　　　　　　　　　　　　　　　
    2020, [Reviewed]
  • The Competitive Advantage of the Vertically Integrated Business Model in Generic Drug Industry:Focusing on Private Brand Product Strategies
    Hirosaki Shin; Koinuma Masayoshi; Akase Tomohide
    Annals of the Society for Industrial Studies, Japan, 2020, [Reviewed]
    In recent years, the generics market in Japan has reached a turbulent period. Due to government policy, the volume share of generics is increasing rapidly. On the other hand, generic companies could not profit more than before because of the reduction in generic prices. As a result, the generic business in many new entrants, mainly innovative pharmaceutical companies, was transferred to a vertically integrated company run by pharmaceutical wholesalers and pharmacies in 2010s. Generic names in Japan have resembled those of private brands（ PBs） such as foodstuffs. In this paper, we conducted a survey analysis of the advantages of a group of vertically integrated companies sell generics as PBs, mainly by NIHON CHOUZAI Co. Ltd., in comparison with previous studies in other industries.
    First, a vertically integrated business model in which both manufacturers and pharmacies are within the group can maintain sales prices and conduct sales activities with a minimum number of MRs. This suggests that sales management costs can be reduced.
    On the other hand, the brands of these generics were derived from the company name, not the pharmacy name. Furthermore, these companies could not acquire the store brand because they also deal with brands of many trading competitors. There were no cases in which generics sold by a vertically integrated company had unique added value in accordance with the needs of the patients or pharmacists. The reason these companies take such a strategy is that pharmacies, rather than patients, have the choice of generics brand. And since the pharmacy has the brand selection right, the pharmacy can immediately switch from innovative medicine to PB generics according to the pharmacy’s intention. These suggest that PB generics are efficient and effective business compared to PB businesses in other industries.
    DOI URL 2
  • Prevalence of drug–drug interaction in atrial fibrillation patients based on a large claims data
    Kenji Momo; Haruna Kobayashi; Yuuka Sugiura; Takeo Yasu; Masayoshi Koinuma; Sei-ichiro Kuroda
    PLOS ONE, 09 Dec. 2019, [Reviewed]
    DOI URL
  • 一般消費者における日常作業状況と花粉症治療薬に求める特徴の関連性について コンジョイント分析およびコレスポンデンス分析を用いた統計学的検討
    Jul. 2019, [Reviewed]
  • Evaluation of the time-to-onset of drug-induced dysphagia using the Japanese Adverse Drug Event Report database　　　　　　　　　　　　　　　
    Toru Koshiishi; Kenji momo; Masayoshi Koinuma; Akiko Takagi; Kiyoshi Okuyama; Hitoshi Nakamura
    Journal of Drug Interaction Research, 2019, [Reviewed]
  • Assessment of “look-alike” packaging designs related to medication errors using information technology
    K. Momo; M. Shimano; Y. Kanezaki; A. Minagawa; A. Takagi; T. Seino; M. Koinuma
    Pharmazie, 2019, [Reviewed]
    DOI URL
  • 病院薬剤師における職務満足度と勤務継続意識の関係についての検討医薬品相互作用研究 42 (3) 184-189, 2018.　　　　　　　　　　　　　　　
    Jan. 2019, [Reviewed]
  • Predictive Factors for Autoimmune Pancreatitis Relapse After 3 Years of Maintenance Therapy
    Nakamura Akira; Ozawa Makiko; Watanabe Takayuki; Ito Tetsuya; Muraki Takashi; Hamano Hideaki; Koinuma Masayoshi; Kawa Shigeyuki
    PANCREAS, Nov. 2018, [Reviewed]
    DOI URL
  • Examining the Relation between Occupational Awareness and Official Positions of Hospital Pharmacists　　　　　　　　　　　　　　　
    Oct. 2018, [Reviewed]
  • Assessment of statin-induced interstitial pneumonia in patients treated for hyperlipidemia using a health insurance claims database in Japan
    Kenji Momo; Akiko Takagi; Atsuko Miyaji; Masayoshi Koinuma
    Pulmonary Pharmacology and Therapeutics, 01 Jun. 2018, [Reviewed]
    DOI URL
  • The effect of wearing night splints for one year on the standing motor function of patients with Duchenne muscular dystrophy.
    Hitomi Nishizawa; Ayumi Matsukiyo; Naoko Shiba; Masayoshi Koinuma; Akinori Nakamura
    Journal of physical therapy science, Apr. 2018, [Reviewed]
    [Purpose] To investigate the effect of night splints on the standing motor function and ankle dorsiflexion angles of patients with Duchenne muscular dystrophy (DMD). [Subjects and Methods] Nine boys (age <11 years) with DMD were divided into the sufficiently-wearing group and the insufficiently-wearing group, according to how often they wore their splint for one year. We evaluated the changes between the pre-implementation and the one-year-after assessments of both the sufficiently-wearing group and the insufficiently-wearing group for the ankle dorsiflexion angle, North Star Ambulatory Assessment, 10-m running time, and time to stand from the floor. [Results] Only the left dorsiflexion angle of the ankle showed significantly difference for the sufficiently-wearing group. For other indicators, there were tendency toward improvement and maintenance in the sufficiently-wearing group. [Conclusion] The standing motor function improved significantly in some patients in the sufficiently-wearing group, suggesting that wearing night splints may promote the improvement and/or maintain of standing motor function in patients with DMD.
    DOI URL
  • Nationwide survey on cerebrotendinous xanthomatosis in Japan
    Yoshiki Sekijima; Shingo Koyama; Tsuneaki Yoshinaga; Masayoshi Koinuma; Yuji Inaba
    Journal of Human Genetics, 01 Mar. 2018, [Reviewed]
    DOI URL
  • Association between polypharmacy and clinical ward pharmacy services in hospitals in Tokyo
    Takeo Yasu; Masayoshi Koinuma; Daisuke Hayashi; Takeshi Horii; Yoshiki Yashiro; Junichi Furuya; Masatoshi Saitoh; Reisuke Seki; Mikio Shirota; Kazufumi Abe
    Geriatrics and Gerontology International, 01 Jan. 2018, [Reviewed]
    DOI URL
  • Modification of the insulin pen assistive device to improve the usability and its evaluation
    Masahiro Murakami; Kenichi Toraishi; Masayoshi Koinuma; Manabu Amano
    Yakugaku Zasshi, 2018, [Reviewed]
    DOI URL
  • Association between lower air pressure and the onset of ischemic colitis
    Takefumi Kimura; Akihiro Shinji; Naoki Tanaka; Masayoshi Koinuma; Maki Yamaura; Tadanobu Nagaya; Satoru Joshita; Michiharu Komatsu; Takeji Umemura; Akira Horiuchi; Shuichi Wada; Eiji Tanaka
    European Journal of Gastroenterology & Hepatology, Sep. 2017, [Reviewed]
    DOI URL
  • Factors influencing adherence to medication based on questionnaire survey　　　　　　　　　　　　　　　
    Manabu Inada; Kazumi Ishitsuka; Mariko Ueda; Masayoshi Koinuma; Hitomi Kashiwase; Masanori Shimada; Yuko Matsuzaki; Kazuhiro Torigoe; Shotaro Sakurai; Tetsuro Yumoto; Hajime Ito
    Japanese Journal of Community Pharmacy, 2017, [Reviewed]
  • Association between endotoxemia and histological features of nonalcoholic fatty liver disease
    Hiroyuki Kitabatake; Naoki Tanaka; Naoyuki Fujimori; Michiharu Komatsu; Ayaka Okubo; Kyogo Kakegawa; Takefumi Kimura; Ayumi Sugiura; Tomoo Yamazaki; Soichiro Shibata; Yuki Ichikawa; Satoru Joshita; Takeji Umemura; Akihiro Matsumoto; Masayoshi Koinuma; Kenji Sano; Toshifumi Aoyama; Eiji Tanaka
    WORLD JOURNAL OF GASTROENTEROLOGY, Jan. 2017, [Reviewed]
    DOI URL
  • Pharmaceutical Approach for the Diagnosis and Treatment of Malignant Syndrome: A Case Study
    Keisuke Kameda; Kazuhiro Watarai; Kenji Takahashi; Tomohisa Shoko; Masayoshi Koinuma; Goro Ikushima
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Jun. 2016, [Reviewed]
    DOI URL
  • 悪性症候群の診断と治療に対する集学的取り組みにおいて薬学的アプローチが有用であった一例　　　　　　　　　　　　　　　
    亀田 圭輔; 渡来 和宏; 高橋 憲二; 庄古 知久; 濃沼 政美; 生島 五郎
    薬学雑誌, Jun. 2016, [Reviewed]
  • How hospitals collaborate in cancer care with community pharmacies in the prescription of oral chemotherapy drugs　　　　　　　　　　　　　　　
    May 2016, [Reviewed]
  • Synthesis and characterization of nitrogen-functionalized graphene oxide in high-temperature and high-pressure ammonia
    F. H. Baldovino; A. T. Quitain; Nathaniel P. Dugos; Susan A. Roces; Masayoshi Koinuma; M. Yuasa; T. Kida
    RSC ADVANCES, 2016, [Reviewed]
    DOI URL
  • 回復期リハビリテーション病棟における薬剤師常駐の必要性と医師・看護師の潜在的なニーズの探索
    藤原 久登; 濃沼 政美; 湯本 哲郎; 前田 拓哉; 上手 真梨子; 河原 英子; 添田 真司; 瀧本 淳; 田村 和敬; 中村 雅敏; 金田 光正; 高尾 良洋; 齋藤 昌久; 加賀谷 肇; 村山 純一郎
    薬学雑誌, Aug. 2015, [Reviewed]
  • Search for Factors Related to Vascular Pain Expression upon Administration of Oxaliplatin into a Peripheral Vein
    高木彰子; 米本奈央; 青山裕也; 藤間有梨; 梶原美智子; 渡辺弘祐; 宮崎美子; 濃沼政美
    癌と化学療法, 15 Jul. 2015, [Reviewed]
  • 誤嚥性肺炎患者の重症度判定指標と退院時転帰との関係についての探索的調査
    Jun. 2015, [Reviewed]
    URL
  • Study on strategy map of the department of pharmacy in the hospital
    31 Mar. 2015, [Reviewed]
    URL
  • Construction and assessment of a novel attitude cultivation program focusing on student's "learning posture" in clinical practice
    石塚和美; 湯本哲郎; 濃沼政美; 鳥越一宏; 山村美保; 湧井宣行; 白水俊介; 町田昌明; 浅井和範; 櫻井正太郎
    J Pharm Commun, 25 Dec. 2014, [Reviewed]
    URL
  • 入院患者の在院日数に対する病棟薬剤業務実施加算算定の影響　　　　　　　　　　　　　　　
    礒野 淳一; 濃沼 政美; 稲葉 健二郎; 菅野 浩; 佐藤 透; 清水 淳一; 加賀谷 肇; 赤瀬 朋秀
    日本病院薬剤師会雑誌, Jun. 2014, [Reviewed]
  • Study on the Benefit of the Constant Presence of Pharmacists at Wards in a Medium-size Hospital (First Report) –Possible Needs from Doctors and Nurses for the Constant Presence of Pharmacists at Wards of Our Hospital–
    Inaba Kenjiro; Koinuma Masayoshi; Kobayashi Motomu; Yumoto Tetsuro; Akase Tomohide
    Journal of Japanese Association for Health Care Administrators, 2014, [Reviewed]
  • 回復期リハビリテーション病棟と一般病棟の病棟薬剤業務の比較 回復期リハビリテーション病棟業務の特徴
    藤原 久登; 濃沼 政美; 湯本 哲郎; 前田 拓哉; 金田 昌之; 綾部 由紀乃; 飯田 純一; 小島 昌徳; 金田 光正; 中山 はるみ; 高尾 良洋; 齋藤 昌久; 加賀谷 肇; 村山 純一郎
    日本病院薬剤師会雑誌, Sep. 2013, [Reviewed]
  • Exploring the reality of switching jobs among hospital pharmacists and trends amongst those having experienced employment changes
    濃沼 政美; 中村 均
    日本医療マネジメント学会雑誌, May 2013, [Reviewed]
  • A Study on the Current Condition and Outlook of Pharmaceutical Economics in Japan
    赤潮 朋秀; 岡本 敬久; 濃沼 政美
    日本経済大学大学院紀要 = The bulletin of the Graduate School of Business Japan University of Economics, Mar. 2013, [Reviewed]
  • Predictability of the implementation rate of clinical trial at the time of the contract
    原 司; 増本 陽秀; 濃沼 政美
    日本医療マネジメント学会雑誌, Mar. 2013, [Reviewed]
  • Development and validation of the Japanese version of the Decisional Conflict Scale to investigate the value of pharmacists' information: a before and after study.
    Takashi Kawaguchi; Kanako Azuma; Takuhiro Yamaguchi; Hiroshi Soeda; Yusuke Sekine; Masayoshi Koinuma; Hironori Takeuchi; Takao Akashi; Sakae Unezaki
    BMC Med. Inf. & Decision Making, 2013, [Reviewed]
    DOI URLDblp URL
  • 病院薬剤師版職務満足度測定尺度(JOBSS-HP27)の開発　　　　　　　　　　　　　　　
    濃沼 政美; 真田 佳美; 山口 諒; 湯本 哲郎; 宮崎 美子; 佐藤 透; 徳永 仁; 高村 徳人; 林 宏行; 中村 均
    社会薬学, Dec. 2012, [Reviewed]
  • Examination of the correlation between the structural composition of hospital clinical pathway committees and clinical pathway usage rates
    濃沼 政美; 平田 美寿貴; 田口 勇基
    日本クリニカルパス学会誌, Oct. 2012, [Reviewed]
  • 不妊症患者の証に関する統計学的検討
    小暮晃子; 熊谷由紀絵; 久重侑子; 草鹿砥千絵; 寺師碩甫; 宮原桂; 赤瀬朋秀; 小菅孝明; 濃沼政美; 中村均
    漢方と最新治療, 15 Aug. 2012, [Reviewed]
  • Predictability on the lead time percentage of the subject incorporation by the clinical trial
    原 司; 濃沼 政美; 中村 均
    日本医療マネジメント学会雑誌, Jul. 2012, [Reviewed]
  • PEG-IFNα-2b/RBV併用療法の血小板減少症関連治療中断を避けるための血小板減少の最低レベルの予測(Prediction of the Lowest Level of Thrombocytopenia to Avoid Thrombocytopenia-related Treatment Discontinuation in PEG-IFNα-2b/RBV Combination Therapy)
    Suzuki Shinichiro; Koinuma Masayoshi; Hoshino Tsuyoshi; Kawaguchi Takashi; Sasaki Yuki; Otsuka Susumu; Yoshida Yoshikazu; Nirei Kazushige; Moriyama Mitsuhiko; Nakamura Hitoshi
    医療薬学, 2012, [Reviewed]
    DOI URL
  • Determinants Affecting Quality of Life: Implications for Pharmacist Counseling for Patients with Breast Cancer in Japan
    Takashi Kawaguchi; Satoru Iwase; Masayoshi Koinuma; Yuki Onodera; Hironori Takeuchi; Megumi Umeda; Tadaharu Matsunaga; Sakae Unezaki; Yoshinori Nagumo
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, Jan. 2012, [Reviewed]
    DOI URL
  • 保険薬局薬剤師の職能拡大に関する薬局薬剤師の意識に影響を及ぼす因子の探索
    徳永仁; 瀬戸口奈央; 濃沼政美; 中西直美; 緒方賢次; 松岡俊和; 佐藤圭創; 中村均; 高村徳人
    社会薬学, 18 Mar. 2011, [Reviewed]
    URL
  • アンケートからみられる病院薬剤師と薬局薬剤師の薬剤師業務に関する意識の比較とその考察　　　　　　　　　　　　　　　
    徳永 仁; 瀬戸口 奈央; 濃沼 政美; 中西 直美; 緒方 賢次; 松岡 俊和; 佐藤 圭創; 中村 均; 高村 徳人
    日本病院薬剤師会雑誌, Feb. 2011, [Reviewed]
  • 統計的手法を用いたクリニカルパス作成に対する方法論の検討―誤嚥性肺炎パスの作成を目的とした院内データの活用法についての考察―
    宮崎美子; 濃沼政美
    日本クリニカルパス学会誌, 29 Oct. 2010, [Reviewed]
  • Survey of Community Pharmacists’Attitudes Regarding Involvement in Taking Vital Signs and Performing Emergency Medical Procedures
    Setoguchi Nao; Tokunaga Jin; Takamura Norito; Ogata Kenji; Yoshida Hiroki; Koinuma Masayoshi; Nakamura Hitoshi; Sato Keizo
    Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences), 10 Sep. 2010, [Reviewed]
    DOI URL
  • 退院時共同指導の推進を目的としたオペレーションズ・リサーチ 日本病院薬剤師会療養病床委員会の取り組み
    濃沼 政美; 宮崎 美子; 岡村 正夫; 沖村 綾子; 杉浦 孝; 田中 協; 田原 雅子; 棗 則明; 中村 均; 安藤 哲信; 賀勢 泰子; 佐藤 秀昭
    医療薬学, 10 May 2010, [Reviewed]
    DOI URL
  • Factors Associated with Neurotoxicity in Patients Receiving FOLFOX 4
    Imai Toru; Hayasaka Masatoshi; Chuma Masayuki; Koinuma Masayoshi; Hayama Tatsuya; Nakayama Toshimitsu; Yoshida Yoshikazu; Tanjoh Katsuhisa
    Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences), 10 May 2010, [Reviewed]
    DOI URL
  • 退院時指導業務に関する現状調査報告　　　　　　　　　　　　　　　
    Feb. 2010
  • Search for the subconsciousness of hospital pharmacists on their practices of blood drawing or injection, and etc.
    Masayoshi Koinuma; Yoshiko Miyazaki; Tetsuro Yumoto; Toru Sato; Shinichiro Suzuki; Hirohumi Nakajima; Motoki Arakawa; Katsuya Koikes; Hideaki Sato; Hitoshi Nakamura
    Yakugaku Zasshi, Feb. 2010, [Reviewed]
    DOI URL
  • The Consciousness Research and Analysis on the Directive Pharmacists Who Provide Pre-education Prior to Clinical Practice -An Effort in the College of Pharmacy Nihon University-
    Shin-ichiro Suzuki; Masayoshi Koinuma; Yukari Hidaka; Katsuya Koike; Hitoshi Nakamura
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Sep. 2009, [Reviewed]
    DOI URL
  • Search for Consciousness of Hospital Pharmacists on the Future Prospects of their Practices and on their Practices of Blood Drawing or Injection
    Masayoshi Koinuma; Yoshie Imai; Manami Kanda; Katsuya Koike; Yoshiko Miyazaki; Toru Sato; Hitoshi Nakamura
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Jul. 2009, [Reviewed]
    DOI URL
  • Awareness of Hospital Pharmacists with Regard to Expanding the Professional Role of Pharmacists and Analysis of Factors Influencing This
    TOKUNAGA Jin; KOINUMA Masayoshi; TAKAMURA Norito; OGATA Kenji; YOSHIDA Hiroki; YAMAMOTO Ryuichi; NAKAMURA Hitoshi
    Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences), 10 Jun. 2009, [Reviewed]
    DOI URL
  • 病院薬剤師業務の新たな方向性についての研究‐看護師に対するアンケート調査の解析‐
    濃沼政美; 星野史朗; 小池勝也; 中村均
    社会薬学, 28 Feb. 2009, [Reviewed]
  • Application of text mining approach to pre-education prior to clinical practice
    Masayoshi Koinuma; Katsuya Koike; Hitoshi Nakamura
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Jun. 2008, [Reviewed]
    DOI URL
  • Pharmacoeconomic Analysis on Boiogito in Conservative Drug Therapy for Knee Osteoarthritis
    KOINUMA Masayoshi; SHIRAGAMI Makoto
    Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences), 10 Aug. 2006, [Reviewed]
    DOI URL
  • 進行非小細胞肺癌における初回化学療法Carboplatin and Monthly Paclitaxel療法とCarboplatin and Weekly Paclitaxel療法の薬剤経済学的検討
    成川仁之; 濃沼政美; 亀井美和子; 蝶名林直彦; 井上忠夫; 白神誠
    医薬品情報学, 16 May 2006, [Reviewed]
    URL
  • The realities and medical expense of hospitalization that originates in outpatient medicine treatment
    Masayoshi Koinuma; Takahisa Yamanashi; Miwako Kamei; Makoto Shiragami
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, May 2006, [Reviewed]
    DOI URL
  • マレイン酸メチルエルゴメトリンをコントロールとしたきゅう帰調血飲の産褥管理における有用性のメタアナリシス(Meta-analysis on the Usefulness in Postpartum Control by Kyukichoketsuin with Methylergometrine Maleate as Control)
    濃沼 政美; 成川 仁之; 亀井 美和子; 白神 誠
    日本東洋医学雑誌, Jan. 2006, [Reviewed]
    DOI URL
  • Dispensing of Health Foods together with Prescription Drugs at Pharmacies
    KOINUMA Masayoshi; YASHIRO Eiko; KAMEI Miwako; SHIRAGAMI Makoto
    Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences), 10 Nov. 2005, [Reviewed]
    We investigated the way that health foods (including those for specified health uses) are sold at pharmacies, awareness of interactions and the extent of information gathering when health foods are dispensed together with prescription drugs. To obtain data for our study, we sent a questionnaire by mail to 176 pharmacies belonging to the Chiba Pharmaceutical Association. The questionnaire asked for background information on pharmacies, and about how health foods are sold, the information given on them, awareness of interactions, information gathering methods and status of interactions in the case that health foods are dispensed together with prescription drugs.<BR>We next analyzed the results for a relationship between the dispensing status and methods of gathering information on interactions in the case of concomitant use of health foods and pharmaceutical products. In doing this, we investigated the independence among groups using the Wilcoxon rank sum test, specifying the average numbers of prescriptions dispensed per day and share of prescription drug sales as dependent variables, and whether or not information on interactions was sought using the internet or by making inquiries to pharmaceutical companies as explanatory variables.<BR>We received completed questionnaires from 77 pharmacies (response rate 43.7%). Based on their responses, the average monthly number of prescriptions per pharmacy was 1, 738.9, dispensing accounted for 68% of sales, and the average man-hours per day was 26.1 hours. The rate for conducting checks concerning health foods at the time of dispensing was 53.2 %. As for the average number of prescriptions handled per day, we concluded that more inquiries were made to pharmaceutical companies as the number of prescriptions handled increased since there was a significant difference between the with and without inquiries to pharmaceutical companies groups (p=0.0037).
    DOI URL
  • 漢方薬の薬剤経済分析のためのフィージビリティー・スタディー(Feasibility Study for the Pharmacoeconomic Analysis of Kampo Medicines)　　　　　　　　　　　　　　　
    濃沼 政美; 亀井 美和子; 松本 邦子; 八木 美才; 白神 誠
    日本東洋医学雑誌, Sep. 2005, [Reviewed]
  • 薬局機能評価マニュアルに係る消費者アンケートの分析―薬局・薬剤師に対する意見の分析結果―
    藤井康博; 亀井美和子; 濃沼政美; 白神誠
    社会薬学, 30 Jul. 2005, [Reviewed]
    URL
  • The Influence of Oil-Based Ink Containing Xylene for Plastic Containers Used in Making Infusions
    KOINUMA Masayoshi; SENOO Makoto; TAKASE Tomonaga; NISHIZAWA Mitsuyo; HIRANO Masaaki; ARAKAWA Hidetoshi; MAEDA Shoko
    Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences), 10 Apr. 2003, [Reviewed]
    DOI URL
  • Antipruritic Effect of Mugwort Lotion for Postburn Hypertrophic Scar Patients
    MATSUURA Kano; OGAWA Rei; KOINUMA Masayoshi; NAKAO Chiyomi; AOKI Ritsu; HYAKUSOKU Hiko
    熱傷, 15 Mar. 2003, [Reviewed]
  • Development and Evaluation of In-Hospital Preparations, "Heparin Lock Syringe Solution for IVH"
    KOINUMA Masayoshi; NISHIZAWA Mitsuyo; SENOO Makoto; TAKASE Tomonaga; HIRANO Masaaki; ITO Katsutoshi; ARAKAWA Hidetoshi; MAEDA Shoko
    Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences), 10 Dec. 2002, [Reviewed]
    DOI URL

MISC

Books and other publications

Lectures, oral presentations, etc.

Research Themes

  • Development of a health support program to support healthy aging for people with spinal cord injuries
    Grant-in-Aid for Scientific Research (C)
    Teikyo Heisei University
    01 Apr. 2025 - 31 Mar. 2028
  • Evaluation of the degree of muscle fatigue to exercise performed by school physical education for children with Duchenne muscular dystrophy
    Grant-in-Aid for Scientific Research (C)
    Shinshu University
    01 Apr. 2019 - 31 Mar. 2022
    The validity of measuring salivary lactate(SLA)with a simple device and the relationship between salivary lactate and blood lactate(BLA)were tested. The results showed that the ICC (2,1) for each subject between the Lactate Pro 2 and the autoanalyzer in the device test was 0.568-0.763, with an overall ICC of 0.773 (95% confidence interval: 0.678 to 0.844, p < 0.01). For the relationship between the two, the cross-correlation coefficient was 0.535 for lag 0 and 0.750 for lag 1, indicating that SLA lagged behind BLA by one measurement minute (5 minutes). It was verified that the use of the existing simple device was reasonable and that the trends for blood and saliva were similar to previous studies.
  • Do drug-administration-assisting devices used by pharmacists improve patients' QOL?
    Grant-in-Aid for Challenging Exploratory Research
    Hyogo University of Health Sciences
    01 Apr. 2014 - 31 Mar. 2017
    People receiving pharmacotherapy encounter difficulties associated with various drugs at the time of their administration. In particular, patients receiving pen-type insulin injections are more likely to encounter difficulties because they usually administer these injections by themselves. Therefore, various drug-administration-assisting devices are commercially available and provided by pharmaceutical companies. However, the convenience of drug administration remains insufficiently improved. The reason for the unresolved issues regarding drug administration is that individual approaches (e.g., changing the shape of administration devices) have not been adopted according to the finger shape of patients or how they apply force to such devices. Against this background, we investigated methods to develop individually-tailored assisting devices, as well as strategies to provide these devices through pharmacies.
  • 病院薬剤部門の職能向上に関する研究　　　　　　　　　　　　　　　
    1993

Industrial Property Rights

Others

  • ★2023年度 研究活動報告書 医薬品安全性評価学（濃沼）
    Apr. 2023 - Mar. 2024
  • ★2022年度 研究活動報告書 医薬品安全性評価学（濃沼）
    Apr. 2022 - Mar. 2023
  • 臨床研究支援センター便り第22号
    Jan. 2023
  • ★2021年度 研究活動報告書 医薬品安全性評価学（濃沼）
    Apr. 2021 - Mar. 2022
  • ★2020年度 研究活動報告書 医薬品安全性評価学（濃沼）
    Apr. 2020 - Mar. 2021

■University education and qualification information

Qualifications, licenses

  • 01 May 1990
  • 01 Oct. 1993
  • 01 Jan. 2005
  • 01 Jan. 2006
  • 01 Apr. 2020