A 90-day repeated oral dose toxicity study of p-cymene in rats
Makiko Kuwagata; Yuko Doi; Hirokatsu Saito; Mariko Tsurumoto; Toshime Igarashi; Takuya Nishimura; Yuhji Taquahashi; Yoko Hirabayashi; Satoshi Kitajima
Fundamental Toxicological Sciences, 2024年

Extracellular vesicle small RNAs secreted from mouse amniotic fluid induced by repeated oral administration of VPA to pregnant mice
Ryuichi Ono; Makiko Kuwagata; Mie Naruse; Akihito Watanabe; Masao Takano; Takuro Hasegawa; Hiromasa Takashima; Yusuke Yoshioka; Takahiro Ochiya; Yoko Hirabayashi; Satoshi Kitajima
Fundamental Toxicological Sciences, 2024年

フードテックを応用した細胞培養食品を含む「新規食品」の安全性確保に関する諸外国の制度比較と最近の動向　　　　　　　　　　　　　　　
五十嵐 智女; 松村 万里; 小川 いずみ; 矢川 千織; 早川 孝彦; 越智 美代子; 齊藤 洋克; 西村 拓也; 桑形 麻樹子; 北嶋 聡
The Journal of Toxicological Sciences, 2023年06月

A 90-day repeated oral dose toxicity study of 2-Butylbenzo[d]isothiazol-3(2H)-one in rats
Makiko Kuwagata; Masaru Tsuboi; Toshime Igarashi; Mariko Tsurumoto; Takuya Nishimura; Yuhji Taquahashi; Satoshi Kitajima
Fundamental Toxicological Sciences, 2023年

A 90-day dose toxicity study of 2-(2H-benzotriazol-2-yl)-6-dodecyl-4-methylphenol in rats
Makiko Kuwagata; Masaru Tsuboi; Toshime Igarashi; Mariko Tsurumoto; Takuya Nishimura; Yuhji Taquahashi; Satoshi Kitajima
Fundamental Toxicological Sciences, 2023年

Development of an inhalation exposure system of a pressurized metered-dose inhaler (pMDI) formulation for small experimental animals
Yuhji Taquahashi; Hirokatsu Saito; Makiko Kuwagata; Satoshi Kitajima
Fundamental Toxicological Sciences, 2021年10月, ［査読有り］

Visualizing the spatial localization of ciclesonide and its metabolites in rat lungs after inhalation of 1-μm aerosol of ciclesonide by desorption electrospray ionization-time of flight mass spectrometry imaging.
Eiichi Yamamoto; Yuhji Taquahashi; Makiko Kuwagata; Hirokatsu Saito; Kohei Matsushita; Takeshi Toyoda; Futoshi Sato; Satoshi Kitajima; Kumiko Ogawa; Ken-Ichi Izutsu; Yoshiro Saito; Yoko Hirabayashi; Yasuo Iimura; Masamitsu Honma; Haruhiro Okuda; Yukihiro Goda
International journal of pharmaceutics, 2021年02月15日, ［査読有り］

Pharmacokinetics of primary metabolites 5-hydroxythalidomide and 5′-hydroxythalidomide formed after oral administration of thalidomide in the rabbit, a thalidomide-sensitive species
Makiko Kuwagata; Takuro Hasegawa; Hiromasa Takashima; Makiko Shimizu; Satoshi Kitajima; Hiroshi Yamazaki
The Journal of Toxicological Sciences, 2021年, ［査読有り］

Diverse unintended on-target mutations induced by zygote genome-editing using CRISPR/Cas9 system
Toshime Igarashi; Yukuto Yasuhiko; Ryuichi Ono; Erika Tachihara; Miki Uchiyama; Atsuya Takagi; Yu Takahashi; Makiko Kuwagata; Satoshi Kitajima
Fundamental Toxicological Sciences, 2021年, ［査読有り］

5-Fluorocytosine induces fetal skeletal malformations in rats by altering expression of Homeobox genes
Takayuki Kumamoto; Mika Senuma; Mai Todoroki; Fumiaki Kumagai; Hajime Imai; Reiko Suzuki; Tetsuo Ogawa; Makiko Kuwagata
Fundamental Toxicological Sciences, 2020年, ［査読有り］

Hypothalamic Monoaminergic Pathology in a Neurodevelopmental Rat Model Showing Prenatal 5-Bromo-2'-Deoxyuridine Treatment-Induced Hyperactivity and Hyporeproductivity.
Makiko Kuwagata; Katsumasa Muneoka; Kazuho Honda; Akira Miyazaki
Neuropsychobiology, 2020年, ［査読有り］

Novel hepatotoxicity biomarkers of extracellular vesicle (EV)-associated miRNAs induced by CCl4.
Ryuichi Ono; Yusuke Yoshioka; Yusuke Furukawa; Mie Naruse; Makiko Kuwagata; Takahiro Ochiya; Satoshi Kitajima; Yoko Hirabayashi
Toxicology reports, 2020年, ［査読有り］

Induction of a thoracolumbar supernumerary rib in rat developmental toxicity studies: A short discussion on the critical window.
Makiko Kuwagata; Mika Senuma; Mai Todoroki; Fumiaki Kumagai; Takayuki Kumamoto; Tetsuo Ogawa
Congenital anomalies, 2019年11月, ［査読有り］

Update of the DevTox data database for harmonized risk assessment and alternative methodologies in developmental toxicology: Report of the 9th Berlin Workshop on Developmental Toxicity.
Roland Solecki; Martina Rauch; Andrea Gall; Jochen Buschmann; Rupert Kellner; Olena Kucheryavenko; Anne Schmitt; Nathalie Delrue; Weihua Li; Jingying Hu; Michio Fujiwara; Makiko Kuwagata; Alberto Mantovani; Susan L Makris; Francisco Paumgartten; Gilbert Schönfelder; Steffen Schneider; Silvia Vogl; Nicole Kleinstreuer; Marlon Schneider; Frank Schulze; Ellen Fritsche; Ruth Clark; Kohei Shiota; Ibrahim Chahoud
Reproductive toxicology (Elmsford, N.Y.), 2019年10月, ［査読有り］

Historical control data on developmental toxicity studies in rats.
Makiko Kuwagata; Yuko Sakai; Sho Tanaka; Hiromasa Takashima; Ryuichi Katagiri; Toshiki Matsuoka; Kenichi Noritake; Mika Senuma; Tatsuya Shimizu; Hitoshi Hojo; Kanata Ibi; Satoshi Kudo; Takafumi Oota; Masayuki Ube; Yoji Miwa; Shimpei Kajita; Tohru Uesugi; Kaoru Yabe; Taishi Tateishi; Nao Nakano; Terumasa Taniguchi; Akihito Yamashita; Takayuki Hirano; Yuka Kirihata; Yumi Sakai; Shino Nishizawa; Michio Fujiwara; Hiroshi Mineshima; Masao Horimoto; Makoto Ema
Congenital anomalies, 2019年07月, ［査読有り］

Stress-reactive rats (high-avoidance female rats) have a shorter lifespan than stress-nonreactive rats (low-avoidance female rats).
Ryo Ohta; Fumiaki Kumagai; Hideki Marumo; Kenji Usumi; Yoshiaki Saito; Makiko Kuwagata
Journal of toxicologic pathology, 2016年04月, ［査読有り］

Distinct effects of the serotonin-noradrenaline reuptake inhibitors milnacipran and venlafaxine on rat pineal monoamines.
Katsumasa Muneoka; Makiko Kuwagata; Tetsuo Ogawa; Seiji Shioda
Neuroreport, 2015年06月17日, ［査読有り］

Mother/offspring co-administration of the traditional herbal remedy yokukansan during the nursing period influences grooming and cerebellar serotonin levels in a rat model of neurodevelopmental disorders.
Katsumasa Muneoka; Makiko Kuwagata; Tetsuo Ogawa; Seiji Shioda
Cerebellum (London, England), 2015年04月, ［査読有り］

Seeking genes responsible for developmental origins of health and disease from the fetal mouse liver following maternal food restriction.
Tetsuo Ogawa; Junko Shibato; Randeep Rakwal; Tomomi Saito; Gaku Tamura; Makiko Kuwagata; Seiji Shioda
Congenital anomalies, 2014年11月, ［査読有り］

Prenatal sodium arsenite affects early development of serotonergic neurons in the fetal rat brain.
Mika Senuma; Chisato Mori; Tetsuo Ogawa; Makiko Kuwagata
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2014年11月, ［査読有り］

Tranexamic acid induces kaolin intake stimulating a pathway involving tachykinin neurokinin 1 receptors in rats.
Hitoshi Kakiuchi; Asako Kawarai-Shimamura; Makiko Kuwagata; Kensuke Orito
European journal of pharmacology, 2014年01月15日, ［査読有り］

Study for collecting background data on Wistar Hannover [Crl:WI(Han)] rats in general toxicity studies--comparative data to Sprague Dawley rats.
Kazuhiro Hayakawa; Yuichi Mimura; Shigehiro Tachibana; Mami Furuya; Terutaka Kodama; Toyohiko Aoki; Satoru Hosokawa; Motoko Fukui; Seiji Shibata; Masanao Yoshida; Takeshi Masuyama; Takahiro Narita; Makiko Kuwagata; Shigeru Hisada; Eiji Maki
The Journal of toxicological sciences, 2013年, ［査読有り］

Abnormal brain function of the rat neonate in a prenatal 5-bromo-2'-deoxyuridine (BrdU)-induced developmental disorder model.
Tetsuo Ogawa; Makiko Kuwagata; Katsumasa Muneoka; Chizu Wakai; Mika Senuma; Hiroko Kubo; Seiji Shioda
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2012年10月, ［査読有り］

Current problems of in vivo developmental neurotoxicity tests and a new in vivo approach focusing on each step of the developing central nervous system.
Makiko Kuwagata
Congenital anomalies, 2012年09月, ［査読有り］

Usefulness of combined in vivo skin comet assay and in vivo skin micronucleus test.
Tomoyasu Toyoizumi; Ryo Ohta; Kumiko Kawakami; Yuzuki Nakagawa; Yoshiyuki Tazura; Makiko Kuwagata; Satoshi Noguchi; Hajime Sui; Kohji Yamakage
Mutation research, 2012年03月18日, ［査読有り］

Use of the in vivo skin comet assay to evaluate the DNA-damaging potential of chemicals applied to the skin.
Tomoyasu Toyoizumi; Ryo Ohta; Yuzuki Nakagawa; Yoshiyuki Tazura; Makiko Kuwagata; Satoshi Noguchi; Kohji Yamakage
Mutation research, 2011年12月24日, ［査読有り］

Hyperactivity induced by prenatal BrdU exposure across several experimental conditions.
Makiko Kuwagata; Tetsuo Ogawa; Katsumasa Muneoka; Seiji Shioda
Congenital anomalies, 2011年12月, ［査読有り］

Effect of Nucleoprotein Diet on Expression of Gene Candidates for Developmental Origins of Health and Disease (DOHaD)
Tetsuo Ogawa; Randeep Rakwal; Junko Shibato; Chika Sawa; Tomomi Saito; Aya Murayama; Makiko Kuwagata; Haruaki Kageyama; Masaji Matsunaga; Kouji Usumi; Seiji Shioda
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE, 2011年09月, ［査読有り］

Seeking gene candidates responsible for developmental origins of health and disease.
Tetsuo Ogawa; Randeep Rakwal; Junko Shibato; Chika Sawa; Tomomi Saito; Aya Murayama; Makiko Kuwagata; Haruaki Kageyama; Michiko Yagi; Kazue Satoh; Seiji Shioda
Congenital anomalies, 2011年09月, ［査読有り］

Distribution of the longevity gene product, SIRT1, in developing mouse organs.
Tetsuo Ogawa; Chizu Wakai; Tomomi Saito; Aya Murayama; Yuuichi Mimura; Sachiko Youfu; Tomoya Nakamachi; Makiko Kuwagata; Kazue Satoh; Seiji Shioda
Congenital anomalies, 2011年06月, ［査読有り］

Effects of the genotoxic agent 5-bromo-2'-deoxyuridine with or without pre-pubertal gonadectomy on brain monoamines and their metabolites in female rats.
Makiko Kuwagata; Katsumasa Muneoka; Tetsuo Ogawa; Seiji Shioda
Brain research bulletin, 2011年05月30日, ［査読有り］

Sex-specific effects of early neonatal progesterone treatment on dopamine and serotonin metabolism in rat striatum and frontal cortex
Katsumasa Muneoka; Makiko Kuwagata; Tetsuo Ogawa; Seiji Shioda
Life Sciences, 2010年12月18日, ［査読有り］

Biphasic effects of neonatal allopregnanolone on striatal dopamine metabolism
Katsumasa Muneoka; Makiko Kuwagata; Yukihiko Shirayama; Tetsuo Ogawa; Seiji Shioda
NeuroReport, 2009年06月17日, ［査読有り］

Observation of fetal brain in a rat valproate-induced autism model: a developmental neurotoxicity study.
Makiko Kuwagata; Tetsuo Ogawa; Seiji Shioda; Tomoko Nagata
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2009年06月, ［査読有り］

Characteristic behavioral anomalies in rats prenatally exposed to 5-bromo-2′-deoxyuridine
Kensuke Orito; Akihiko Morishima; Tetsuo Ogawa; Katsumasa Muneoka; Makiko Kuwagata; Jiro Takata; Kenichi Mishima; Michihiro Fujiwara
International Journal of Developmental Neuroscience, 2009年02月, ［査読有り］

Valproate-induced developmental neurotoxicity is affected by maternal conditions including shipping stress and environmental change during early pregnancy.
Tetsuo Ogawa; Makiko Kuwagata; Yasunori Hori; Seiji Shioda
Toxicology letters, 2007年11月01日, ［査読有り］

The evaluation of early embryonic neurogenesis after exposure to the genotoxic agent 5-bromo-2'-deoxyuridine in mice.
Makiko Kuwagata; Tetsuo Ogawa; Tomoko Nagata; Seiji Shioda
Neurotoxicology, 2007年07月, ［査読有り］

Dopamine transporter density and behavioral response to methylphenidate in a hyperlocomotor rat model
Katsumasa Muneoka; Makiko Kuwagata; Masaaki Iwata; Yukihiko Shirayama; Tetsuo Ogawa; Morikuni Takigawa
Congenital Anomalies, 2006年09月, ［査読有り］

S-100B expression in neonatal rat cortical "barrels" and thalamic "barreloids"
Katsumasa T. Muneoka; Hisayuki Funahashi; Tetsuo Ogawa; Makiko Kuwagata; Patricia M. Whitaker-Azmitia; Seiji Shioda
BREATHING, FEEDING AND NEUROPROTECTION, 2006年, ［査読有り］

Neuropathological examination of fetal rat brain in the 5-bromo-2′-deoxyuridine-induced neurodevelopmental disorder model
Tetsuo Ogawa; Makiko Kuwagata; Katsumasa T. Muneoka; Seiji Shioda
Congenital Anomalies, 2005年03月, ［査読有り］

Locomotor hyperactivity following prenatal exposure to 5-bromo-2′- deoxyuridine: Neurochemical and behavioral evidence of dopaminergic and serotonergic alterations
Makiko Kuwagata; Katsumasa T. Muneoka; Tetsuo Ogawa; Morikuni Takigawa; Tetsuji Nagao
Toxicology Letters, 2004年08月30日, ［査読有り］

Intrauterine position and postnatal growth in Sprague-Dawley rats and ICR mice
T Nagao; K Wada; M Kuwagata; M Nakagomi; C Watanabe; S Yoshimura; Y Saito; K Usumi; J Kanno
REPRODUCTIVE TOXICOLOGY, 2004年01月, ［査読有り］

Diverse on-target mutations in the genome-edited mice and their transmission to the next generation
Toshime Igarashi; Yukuto Yasuhiko; Ryuichi Ono; Yu Takahashi; Makiko Kuwagata; Satoshi Kitajima
Experimental Animals, 2024年

「新規の食品」の安全性を確保するための諸外国の制度比較
五十嵐智女; 松村万里; 小川いづみ; 矢川千織; 早川孝彦; 越智美代子; 齊藤 洋克; 桒形麻樹子; 北嶋聡
Journal of Toxicological Sciences, 2022年

ビスフェノール類似体4,4'-(1,3-dimethylbutylidene)diphenolの卵巣摘出マウスにおける皮下および経口投与による子宮肥大試験
五十嵐智女; 藤井咲子; 釣本真理子; 高橋祐次; 北嶋聡; 桒形麻樹子
Journal of Toxicological Sciences, 2022年

25th anniversary of the Berlin workshop on developmental toxicology: DevTox database update, challenges in risk assessment of developmental neurotoxicity and alternative methodologies in bone development and growth
Philip Marx-Stoelting; Marize de L.M. Solano; Hiroaki Aoyama; Ralf H. Adams; Anna Bal-Price; Jochen Buschmann; Ibrahim Chahoud; Ruth Clark; Tian Fang; Michio Fujiwara; Michael Gelinsky; Konstanze Grote; Masao Horimoto; Susanne Hougaard Bennekou; Rupert Kellner; Makiko Kuwagata; Marcel Leist; Annemarie Lang; Weihua Li; Alberto Mantovani; Susan L. Makris; Francisco Paumgartten; Monique Perron; Magdalini Sachana; Anne Schmitt; Steffen Schneider; Gilbert Schönfelder; Frank Schulze; Kohei Shiota; Roland Solecki
Reproductive Toxicology, 2021年03月01日

CRISPR/Casシステムにより作製したノックインマウスN0世代に誘発された、オンターゲット部位での多様な非意図的変異の生殖細胞系列伝達について
Toshime Igarashi; Yukuto Yasuhiko; Ryuichi Ono; Erika Tachihara; Miki Uchiyama; Atsuya Takagi; Yu Takahashi; Makiko Kuwagata; Satoshi Kitajima
Journal of Toxicological Sciences, 2021年

CRISPR/Cas9-mediated genome editing of mouse zygotes induces diverse on-target unintentional mutations.
Toshime Igarashi; Yukuto Yasuhiko; Ryuichi Ono; Erika Tachihara; Yu Takahashi; Makiko Kuwagata; Satoshi Kitajima
Journal of Toxicological Sciences, 2020年

生活習慣病胎児期起源説に基づく生活習慣病関連遺伝子の網羅的検索　　　　　　　　　　　　　　　
小川 哲郎; ラクワル・ランディープ; 柴藤 淳子; 澤 智華; 齋藤 智美; 村山 綾; 桑形 麻樹子; 影山 晴秋; 佐藤 和恵; 塩田 清二
日本抗加齢医学会総会プログラム・抄録集, 2011年04月

P-035 ヘアレスマウスを用いた皮膚コメット・小核コンビネーション試験の検討(ポスターセッション,安全・安心のための知的ネットワークの構築:分子生物学的からレギュラトリーサイエンスまで)
豊泉 友康; 太田 亮; 川上 久美子; 中川 ゆづき; 田面 喜之; 桑形 麻樹子; 野口 聡; 須井 哉; 山影 康次
日本環境変異原学会大会プログラム・要旨集, 2011年

ラット胎生期バルプロ酸曝露による自閉症モデルの胎児および新生児脳の観察　　　　　　　　　　　　　　　
桑形 麻樹子; 小川 哲郎; 影山 晴秋; 永田 伴子; 塩田 清二
解剖学雑誌, 2010年03月

Behavioral and reproductive function of rat male offspring treated prenatally with 5-bromo-2'-deoxyuridine
KUWAGATA M
Reprod Toxicol, 1998年

CT装置を用いた腰部過剰肋骨発現メカニズムの解明
Makiko Kuwagata
9th Berlin-Workshop on Developmental Toxicology, 2018年09月14日, ［招待有り］