Paper

• Development of a New Distyrylbenzene-Derivative Amyloid-β-aggregation and Fibril Formation Inhibitor.
  Joint Author, Hideharu Suzuki, Akihito Ishigami, Ayako Orimoto, Akihiro Matsuyama, Setsuko Handa, Naoki Maruyama, Yuusaku Yokoyama, Hiroaki Okuno, and Masamichi Nakakoshi, Lead, Several new amyloid-β (Aβ) aggregation inhibitors were synthesized according to our theory that a hydrophilic moiety could be attached to the Aβ-recognition unit for the purpose of preventing amyloid plaque formation., 60 巻, 9 号, 1164, 1170, Sep. 2012, Exist, Not exist, English, Research papers (academic journals), International, Not International Collabolation, https://doi.org/10.1248/cpb.c12-00365
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• A practical regioselective synthesis of alkylthio- or arylthioindoles without the use of smelly compounds such as thiols.
  Joint Author, Toshihiko Hamashima, Yoshiaki Mori, Kazunori Sawada, Yuko Kasahara, Daisuke Murayama, Yuto Kamei, Hiroaki Okuno, Yuusaku Yokoyama, Hideharu Suzuki, Last|Corresponding,

  A convenient method for the synthesis of 3-methylthioindoles has been established which does not use smelly compounds such as thiol derivatives. The method, which introduces an alkyl- or arylthio-group into the C3-position of the indole skeleton, was extended to the direct introduction of a methylthio or bromo group at the C2-position using 3-methylthioindoles.

  , 61 巻, 3 号, 292, 303, Mar. 2013, Exist, Not exist, English, Research papers (academic journals), International, Not International Collabolation, https://doi.org/10.1248/cpb.c12-00882
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• Pd-Catalyzed Benzylic C-H Amidation with Benzyl Alcohols in Water: A Strategy To Construct Quinazolinones
  Joint Author, Hidemasa Hikawa, Yukari Ino, Hideharu Suzuki, and Yuusaku Yokoyama,

  A novel method for the synthesis of 4-phenyl- quinazolinones via a palladium-catalyzed domino reaction of o- aminobenzamides with benzyl alcohols is developed.

  , J. Org. Chem. 2012, 77 (16), 7046?7051., American Chemical Society, 77巻, 16号, 7046, 7051, Sep. 2012, Exist, Not exist, English, Research papers (academic journals), International, Not International Collabolation, https://doi.org/10.1021/jo301282n
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• N-Benzylation/Benzylic C-H Amidation Cascade by the (n3-Benzyl)palladium System in Aqueous Media: An Effective Pathway for the Direct Construction of 3-Phenyl-3,4-dihydro- (2H )-1,2,4-benzothiadiazine 1,1-Dioxides
  Joint Author, We demonstrate a unique strategy for a benzylation/benzylic C-H amidation cascade reaction by the (n3-benzyl)palladium system derived from a palladium catalyst and benzyl alcohol. This tandem process is devised as a new synthetic route for 3-phenyl-3,4-dihydro-(2H)-1,2,4-benzothiadiazine-1,1-dioxide., ADVANCED SYNTHESIS & CATALYSIS 2013, 355, 2308 ? 2320., Wiley, 2013, 355, 2308, 2320, Aug. 2013, Exist, Not exist, English, Research papers (academic journals), International, Not International Collabolation, https://doi.org/10.1002/adsc.201300317
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• Synthesis and biological evaluation of novel tryptoline derivatives as indoleamine 2, 3- dioxygenase (IDO) inhibitors.
  Joint Author, Minoru Tanaka 1 , Xin Li, Hidemasa Hikawa, Takafumi Suzuki, Katsuhiko Tsutsumi, Masashi Sato, Osamu Takikawa, Hideharu Suzuki, Yuusaku Yokoyama, Indoleamine 2,3-dioxygenase (IDO) plays a significant role in several disorders such as Alzheimer's disease, age-related cataracts and tumors. A series of novel tryptoline derivatives were synthesized and evaluated for their inhibitory activity against IDO. Substituted tryptoline derivatives (11a, 11c, 11e, 12b and 12c) were demonstrated to be more potent than known inhibitor MTH-Trp., Bioorganic & Medicinal Chemistry 2013, 21(5), 1159-1165., Elsevier, 2013, 5, 1159, 1165, Jan. 2013, Exist, Not exist, English, Research papers (academic journals), International, Not International Collabolation, 10.1016/j.bmc.2012.12.028, 23337802
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