Takenori Natori

Faculty of Pharmaceutical Sciences,Department of Pharmaceutical SciencesProfessor
Graduate School of Pharmaceutical Sciences,Doctoral Program in Pharmaceutical SciencesProfessor
Last Updated :2025/10/07

■Researcher basic information

Degree

  • Doctor of Pharmacy, Kyushu University, Mar. 1984
  • Master of Technology Management (Professional), Tokyo University of Science, Mar. 2007

Research Keyword

  • NKT cells

Field Of Study

  • Life sciences, Bioorganic chemistry

■Research activity information

Paper

  • Marine natural products and immune-acting substances, basic research of α-galactosylceramides               
    2019
  • Protection of differentiating neuronal cells from amyloid β peptide-induced injury by alkaline extract of leaves of Sasa senanensis Rehder               
    Hiroshi Sakagami; Mayumi Tsuji; Mineko Tomomura; Yoshiko Masuda; Soichi Iwama; Mika Nakagawa; Hayato Suzuki; Kenta Tanaka; Tomoyuki Abe; Nobuaki Tamura; Akito Tomomura; Satoshi Yokose; Hiroshi Takeshita; Takenori Natori; Misaki Horiuchi; Tomohiro Fujisawa; Yuji Kikuchi; Katsuji Oguchi; Toshikazu Yasui; Hiroshi Oizumi; Takaaki Oizumi
    in vivo, 2018
  • クマザサ葉アルカリ抽出液(ササヘルス®)の卓越した紫外線防護効果               
    2017
  • Induction of Apoptosis in Human Oral Keratinocyte by Doxorubicin               
    Hiroshi Sakagami; Noriyuki Okudaira; Yoshiko Masuda; Osamu Amano; Satoshi Yokose; Yumiko Kanda; Madoka Suguro; Takenori Natori; Hiroshi Oizumi; Takaaki Oizumi
    Anticancer Research, 2017
  • 研究キャリアにおける専門性と人脈構築               
    2016
  • ササヘルスの卓越した抗ウイルス活性               
    2016
  • Synergism of alkaline extract of the leaves of Sasa senanensis Rehder and antiviral agents               
    Hiroshi Sakagami; Kunihiko Fukuchi; Taisei Kanamoto; Shigemi Terakubo; Hideki Nakashima; Takenori Natori; Madoka Suguro-Kitajima; Hiroshi Oizumi; Toshikazu Yasui; Takaaki Oizumi
    in vivo, 2016
  • Prominent anti-UV activity and possible cosmetic potential of lignin-carbohydrate complex               
    Hiroshi Sakagami; Hong Sheng; Noriyuki Okudaira; Toshikazu Yasui; Hidetsugu Wakabayashi; Junie Jia; Takenori Natori; Madoka Suguro-Kitajima; Hiroshi Oizumi; Takaaki Oizumi
    in vivo, 2016
  • Anti-halitosis effect of toothpaste supplemented with alkaline extract of the leaves of Sasa senanensis Rehder               
    Hiroshi Sakagami; Hong Sheng; Koki Ono; Yusuke Komine; Tomoharu Miyadai; Yuji Terada; Daisuke Nakadai; Shoji Tanaka; Masaru Matsumoto; Toshikazu Yasui; Koichi Watanabe; Jia Junye; Takenori Natori; Madoka Suguro-Kitajima; Hiroshi Oizumi; Takaaki Oizumi
    in vivo, 2016
  • 対談:広がるクマ笹の可能性―最新研究から見る未来の可能性―               
    2015
  • Interaction on hydrated α-galactosylceramide with nonionic surfactants and formation of dispersion including gel phases               
    Minoru Nakano; Yousuke Nakatani; Atsuhiko Sugita; Tomoaki Kamo; Takenori Natori; Tetsuro Handa
    Langmuer, 2003, [Reviewed]
  • NKT細胞活性化糖脂質リガンドKRN7000の開発               
    2002
  • Glycolipid antigen processing for presentation by CD1d molecules               
    TI. Prigozy; O. Naidenko; P. Qasba; D. Elewau; L. Brossay; A. Khurana; T. Natori; Y. Koezuka; A. Kulkarni; M. Kronenberg
    Science, 2001, [Reviewed]
  • Anomeric effects on the stability of bilayers of galactosylphytoceramides and on the interaction with phospholipids               
    Minoru Nakano; Rui Inoue; Motoko Koda; Teruyuki Baba; Hiroki Matsunaga; Takenori Natori; Tetsuro Handa
    Langmuer, 2000, [Reviewed]
  • Antitumor activity of KRN7000 (α-galactosylceramide) and its novel immunostimulatory mechanism               
    Yasuhiko Koezuka; Kazuhiro Motoki; Teruyuki Sakai; Takenori Natori
    Recent Res. Devel. Cancer, 1999
  • Structure-activity relationship and conformational analysis of monoglycosylceramide on the syngeneic mixed leucocyte reaction               
    H. Iijima; K. Kimura; T. Sakai; A. Uchimura; T. Shimizu; H. Ueno; T. Natori; Y. Koezuka
    Bioorg. Med. Chem., 1998, [Reviewed]
  • Effect of α- and β-galactosylated C2-ceramides on the immune system               
    Teruyuki Sakai; Hitomi Ueno; Takenori Natori; Akira Uchimura; Kazuhiro Motoki; Yasuhiko Koezuka
    J. Med. Chem., 1998, [Reviewed]
  • 海洋天然物の新しい薬理活性:沖縄産海綿の生産するagelasphinを母化合物とするKRN7000の開発               
    1997
  • Poecillanosine, a new free radical scavenger from the marine sponge Poecillastra spec. aff. tenilaminavis               
    Takenori Natori; Yoko Kataoka; Shinichiro Kato; Hiroyuki Kawai; Nobuhiro Fusetani
    Tetrahedron Lett., 1997, [Reviewed]
  • Immunostimulatory activites of monoglycosylated α-galactosylceramides               
    Akira Uchimura; Toshiyuki Shimizu; Masahiro Morita; Hitomi Ueno; Kazuhiro Motoki; Hideaki Fukushima; Takenori Natori; Yasuhiko Koezuka
    Bioorg. Med. Chem,, 1997, [Reviewed]
  • Immunostimulatory activities of mono- or diglycosylated α-galactosylceramides,               
    Akira Uchimura; Toshiyuki Shimizu; Miiko Nakajima; Hitomi Ueno; Kazuhiro Motoki; Hideaki Fukushima; Takenori Natori; Yasuhiko Koezuka
    Bioorg. Med. Chem., 1997, [Reviewed]
  • Practical total synthesis of (2S,3S,4R)-1-o-(α-D-galactopyranosyl)-N-hexacosanoyl-2-amino-1,3,4- octadecanetriol, the antitumorial and immunostimuatory α-galactosylceramide, KRN7000               
    Masahiro Morita; Eiji Sawa; Kazuo Yamaji; Teruyuki Sakai; Takenori Natori; Yasuhiko, Koezuka; Hideaki Fukushima; Kohji Akimoto
    Biosci. Biotrch. Biochem., 1996, [Reviewed]
  • Enhancing effects of Agelasphin-11 on natural killer cell activities of normal and tumor-bearing mice               
    Eiichi Kobayashi; Kazuhiro Morita; Takenori Natori; Takeshi Uchida; Hideaki Fukushima; Yasuhiko Koezuka
    Biol. Pharm. Bull., 1996, [Reviewed]
  • Structure-activity relationship of α-galactosylceramides against B16-bearing mice               
    Masahiro Morita; Kazuhiro Motoki; Kohji Akimoto; Takenori Natori; Teruyuki Sakai; Eiji Sawa; Kazuo Yamaji; Yasuhiko Koezuka; Eiichi Kobayashi; Hideaki Fukushima
    J. Med. Chem., 1995, [Reviewed]
  • Synthesis of α-, β-monoglycosylceramides and four diastereomers of an α-galactosylceramide               
    Masahiro Morita; Takenori Natori; Kohji Akomoto; Tatsushi Osawa; Hideaki Fukushima; Yasuhiko Koezuka
    Bioorganic Med. Chem. Lett., 1995, [Reviewed]
  • Agelasphins, novel antitumor and immunostimulatory cerebrosides from the marine sponge Agelas mauritianus               
    Takenori Natori; Masahiro Morita; Kohji Akimoto; Yasuhiko Koezuka
    Tetrahedron, 1994, [Reviewed]
  • Synthesis and stereochemistry of Agelasphin-9b               
    Kohji Akimoto; Takenori Natori; Masahiro Morita
    Tetrahedron Lett., 1993, [Reviewed]
  • Agelasphins, novel α-galactosylceramides from the marine sponge Agelas maurithianus               
    Takenori Natori; Yasuhiko Koezuka; Tatsuo Higa
    Tetrahedron Lett., 1993, [Reviewed]
  • Structure of three ganglioside molecular species and a homogeneous ganglioside, and biological activity of the ganglioside               
    Ryuichi Higuchi; Kouji Inagaki; Takenori Natori; Tetsuya Komori; Shinichi Kawajiri
    Liebigs Ann. Chem., 1991, [Reviewed]
  • Isolation and characterization of Acanthacerebroside B and structure elucidation of related, nearly homogeneous cerebrosides               
    Ryuichi Higuchi; Takenori Natori; Tetsuya Komori
    Liebigs Ann. Chem., 1990, [Reviewed]
  • Kalihinene and Isokarihinol B, cytotoxic diterpene isonitriles from the marine sponge Acanthella klethra.               
    N. Fusetani; K. Yasumuro; H. Kawai; T. Natori; L. Brinen; J. Clardy
    Tetrahedron Lett., 1990, [Reviewed]
  • Tubiporein, a novel type of diterpene from a Japanese soft coral Tubipora sp.               
    Takenori Natori; Hiroyuki Kawai; Nobuhiro Fusetani
    Tetrahedron Lett., 1990, [Reviewed]

Books and other publications

Lectures, oral presentations, etc.

  • 海洋天然物と免疫作動性物質〜α-GalCer の基礎について〜               
    01 Dec. 2018, [Invited]
  • 海洋天然物探索から始まったNKT細胞研究               
    15 Sep. 2018, [Invited]
  • 海洋天然物を医薬品に ー分子の発見から臨床試験へー               
    16 Jul. 2003, [Invited]
  • 海洋天然物の新しい薬理活性 ー沖縄産海綿が生産するagelasphinを母化合物とするKRN7000の開発ー               
    03 Apr. 1998, [Invited]

Affiliated academic society

  • Present
    日本薬学会               

Industrial Property Rights

  • 特許7212229, 光線力学療法に用いるための殺菌剤               
  • 特許3068910, 新規スフィンゴ糖脂質、その製造法および使用               
  • 特許2774194, 新規スフィンゴ糖脂質、その製造法および使用               

■University education and qualification information

Qualifications, licenses

  • 01 Jul. 1985
  • 01 Feb. 1989
  • 01 Nov. 1994
  • 01 Jun. 1995
  • 01 Jan. 2014