Doctoral Program in Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, The University of Tokyo

Cloning of cDNA for cathepsin B mRNA 3'-untranslated-region-binding protein(CBBP),and characterization of recombinant CBBP.
We isolated a cDNA for cathepsin B mRNA 3'-untranslated-region-binding protein (CBBP) and showed that it contained RNA binding motifs such as RGG box and zinc finger motif.

, J.Biochem., Mar. 2001, Exist

Targeted disruption of a pupal hemocyte protein of Sarcophaga by RNA interference.
Joint Author, RNA interference was found to be a useful technique for silencing the expression of a specific gene in pupal hemocytes of Sarcophaga., Eur.J.Biochem., Oct. 2001, Exist

Correlation between the catalase level in tumor cells and their sensitivity to N-β-alanyl-5-S-glutathionyl-3,4-dihydroxyphenylalanine (5-S-GAD).
Joint Author, We demonstrated that the cellular catalase level was crucial for cell sensitivity to 5-S-GAD, an anti-tumor substance derived from insect., J.Biochem., Apr. 2004, Exist

Inhibition of in vivo angiogenesis by N-β-alanyl-5-S-glutathionyl-3,4-dihydroxyphenylalanine.
Joint Author, We showed that 5-S-GAD inhibited tumor cell-induced angiogenesis. 5-S-GAD also inhibited vascular endothelial growth factor-induced angiogenesis and embryonic angiogenesis., Eur.J.Phrmacol., Apr. 2006, Exist

A long-lived o-semiquinone radical anion is formed from N-β-alanyl-5-S-glutathionyl-3,4-dihydroxyphenylalanine(5-S-GAD),an insect-derived antibacterial substance.
Joint Author, We found that an o-semiquinone radical anion was formed from 5-S-GAD. This radical formation is involved in the production of hydrogen peroxide from 5-S-GAD., J.Biochem., Jul. 2007, Exist