Hiroko Okinaga
| President | Professor |
Last Updated :2025/10/07
■Researcher basic information
■Career
Career
- Jun. 2006 - Present
Teikyo University - Jun. 2006 - Present
Teikyo University, School of Medicine - Apr. 2005 - Present
- Jan. 2004 - Present
- Dec. 2001 - Present
- Jun. 2001 - May 2006
Teikyo University, School of Medicine - Nov. 2000 - May 2006
Teikyo University, Institute of Global Education - Apr. 2006
The University of Tokyo, Nephrology and Endocrinology, Faculty of Medicine University Hospital - Apr. 2002
The University of Tokyo, Nephrology and Endocrinology, Faculty of Medicine University Hospital - May 1999 - May 2001
Educational Background
Member History
■Research activity information
Paper
- 看護師の離職意向に影響を及ぼす要因の検討
Jul. 2019 - 医療系総合大学教員における離職意向に関する仕事と家庭の要因の検討
Nov. 2018 - 看護師のバーンアウトに影響を及ぼす要因の検討
Nov. 2018 - 看護師の離職意向に影響を及ぼす要因の検討
May 2018 - 科研費若手研究採択医師におけるメンター尺度の開発・続報
Mar. 2018 - メンターの特性とメンティーの精神疲労感との関連の件
Mar. 2018 - Induction of AhR-Mediated Gene Transcription by Coffee
Toshio Ishikawa; Satoshi Takahashi; Koji Morita; Hiroko Okinaga; Tamio Teramoto
PLOS ONE, Jul. 2014, [Reviewed] - Molecular status of pituitary carcinoma and atypical adenoma that contributes the effectiveness of temozolomide
Akira Matsuno; Mineko Murakami; Katsumi Hoya; Shoko M. Yamada; Shinya Miyamoto; So Yamada; Jae-Hyun Son; Hajime Nishido; Fuyuaki Ide; Hiroshi Nagashima; Mutsumi Sugaya; Toshio Hirohata; Akiko Mizutani; Hiroko Okinaga; Yudo Ishii; Shigeyuki Tahara; Akira Teramoto; R. Yoshiyuki Osamura
MEDICAL MOLECULAR MORPHOLOGY, Mar. 2014, [Reviewed] - Histone acetyltransferase Hbo1 destabilizes estrogen receptor α by ubiquitination and modulates proliferation of breast cancers.
Masayoshi Iizuka; Takao Susa; Yoshihisa Takahashi; Mimi Tamamori-Adachi; Takashi Kajitani; Hiroko Okinaga; Toshio Fukusato; Tomoki Okazaki
Cancer science, Dec. 2013, [Reviewed]
The estrogen receptor (ER) is a key molecule for growth of breast cancers. It has been a successful target for treatment of breast cancers. Elucidation of the ER expression mechanism is of importance for designing therapeutics for ER-positive breast cancers. However, the detailed mechanism of ER stability is still unclear. Here, we report that histone acetyltransferase Hbo1 promotes destabilization of estrogen receptor α (ERα) in breast cancers through lysine 48-linked ubiquitination. The acetyltransferase activity of Hbo1 is linked to its activity for ERα ubiquitination. Depletion of Hbo1 and anti-estrogen treatment displayed a potent growth suppression of breast cancer cell line. Hbo1 modulated transcription by ERα. Mutually exclusive expression of Hbo1 and ERα was observed in roughly half of the human breast tumors examined in the present study. Modulation of ER stability by Hbo1 in breast cancers may provide a novel therapeutic possibility. - Modified S/MAR episomal vectors for stably expressing fluorescent protein-tagged transgenes with small cell-to-cell fluctuations
Akiko Mizutani; Eri Kikkawa; Akira Matsuno; Atsuko Shigenari; Hiroko Okinaga; Mineko Murakami; Hideyuki Ishida; Masafumi Tanaka; Hidetoshi Inoko
ANALYTICAL BIOCHEMISTRY, Dec. 2013, [Reviewed] - Urinary growth hormone level and insulin-like growth factor-1 standard deviation score (IGF-SDS) can discriminate adult patients with severe growth hormone deficiency
Toshio Hirohata; Nobuhito Saito; Koji Takano; So Yamada; Jae-Hyun Son; Shoko M. Yamada; Hiroshi Nakaguchi; Katsumi Hoya; Mineko Murakami; Akiko Mizutani; Hiroko Okinaga; Akira Matsuno
ENDOCRINE JOURNAL, Mar. 2013, [Reviewed] - Clinicopathological and Molecular Histochemical Review of Skull Base Metastasis from Differentiated Thyroid Carcinoma
Akira Matsuno; Mineko Murakami; Katsumi Hoya; Shoko M. Yamada; Shinya Miyamoto; So Yamada; Jae-Hyun Son; Hajime Nishido; Fuyuaki Ide; Hiroshi Nagashima; Mutsumi Sugaya; Toshio Hirohata; Akiko Mizutani; Hiroko Okinaga; Yudo Ishii; Shigeyuki Tahara; Akira Teramoto; R. Yoshiyuki Osamura; Kazuto Yamazaki; Yasuo Ishida
ACTA HISTOCHEMICA ET CYTOCHEMICA, 2013, [Reviewed] - Primary polydipsia, but not accumulated ceramide, causes lethal renal damage in saposin D-deficient mice
Harumi Hisaki; Junko Matsuda; Keiko Tadano-Aritomi; Shunya Uchida; Hiroko Okinaga; Makoto Miyagawa; Mimi Tamamori-Adachi; Masayoshi Iizuka; Tomoki Okazaki
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, Oct. 2012, [Reviewed] - Serum from Methimazole-Treated Patients Induces Activation of Aryl Hydrocarbon Receptor, a Transcription Factor That Binds to Dioxin-Response Elements
Toshio Ishikawa; Hiroko Okinaga; Satoshi Takahashi; Maiko Numakura; Yamato Mashimo; Nakayuki Yoshimura; Tomomi Maeda; Daisuke Inoue; Ryo Okazaki; Makoto Kinoshita; J. Larry Jameson; Tamio Teramoto
THYROID, Aug. 2012, [Reviewed] - Functional molecular morphology of anterior pituitary cells, from hormone production to intracellular transport and secretion
Akira Matsuno; Akiko Mizutani; Hiroko Okinaga; Koji Takano; So Yamada; Shoko M. Yamada; Hiroshi Nakaguchi; Katsumi Hoya; Mineko Murakami; Masato Takeuchi; Mutsumi Sugaya; Johbu Itoh; Susumu Takekoshi; R. Yoshiyuki Osamura
MEDICAL MOLECULAR MORPHOLOGY, Jun. 2011, [Reviewed] - A Mechanism of Acquiring Temozolomide Resistance During Transformation of Atypical Prolactinoma Into Prolactin-Producing Pituitary Carcinoma: Case Report
Mineko Murakami; Akiko Mizutani; Shuichiro Asano; Hideki Katakami; Yoshinori Ozawa; Kazuto Yamazaki; Yasuo Ishida; Koji Takano; Hiroko Okinaga; Akira Matsuno
NEUROSURGERY, Jun. 2011, [Reviewed] - Molecular Morphology of Pituitary Cells, from Conventional Immunohistochemistry to Fluorescein Imaging
Akira Matsuno; Akiko Mizutani; Hiroko Okinaga; Koji Takano; So Yamada; Shoko M. Yamada; Hiroshi Nakaguchi; Katsumi Hoya; Mineko Murakami; Masato Takeuchi; Mutsumi Sugaya; Johbu Itoh; Susumu Takekoshi; R. Yoshiyuki Osamura
MOLECULES, May 2011, [Reviewed] - Negative regulation of parathyroid hormone-related protein expression by steroid hormones
Takashi Kajitani; Mimi Tamamori-Adachi; Hiroko Okinaga; Minoru Chikamori; Masayoshi Iizuka; Tomoki Okazaki
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Apr. 2011, [Reviewed] - Current trends in the treatment of malignant pituitary tumors
Matsuno A; Murakami M; Mizutani A; Nakaguchi H; Yamada S M; Hoya K; Yamada S; Onda Y; Takeuchi M; Okinaga H
Current Trends in Endocrinology, 2010, [Reviewed] - GHRH-GH同時産生下垂体腺腫に対するオクトレオチドLARとカベルゴリンによる併用療法
Nov. 2009, [Reviewed] - Preoperative Elevated Serum Growth Hormone is Preventive of Osteopenia in Postsurgical Patients With Pituitary Somatotroph Adenomas Comparison With Clinically Nonfunctioning Adenomas
Mitsuyoshi Sasaki; Ryo Okazaki; Daisuke Inoue; Michi Nakashima; Fuyuaki Ide; Hiroshi Nakaguchi; Shoko M. Yamada; Katsumi Hoya; Mineko Murakami; Akiko Mizutani; Hiroko Okinaga; Akira Matsuno
ENDOCRINOLOGIST, Sep. 2009, [Reviewed] - Molecular pathogenesis and functional analysis of pituitary adenoma
Matsuno A; Mizutani A; Takekoshi S; Osamura R.Y; Sanno N; Teramoto A; Ide F; Yamada S; Sasaki M; Nakaguchi H; Yamada S M; Hoya K; Murakami M; Okinaga H
Current Trends in Neurology, 2009, [Reviewed] - ドーパミンアゴニストが無効な異型性プロラクチノーマに対するテモゾロマイドによる薬物治療
Jun. 2008, [Reviewed] - Co-transfection of EYFP-GH and ECFP-rab3B in an experimental pituitary GH3 cell: a role of rab3B in secretion of GH through porosome
Akira Matsuno; Johbu Itoh; Akiko Mizutani; Susumu Takekoshi; R. Yoshiyuki Osamura; Hiroko Okinaga; Fuyuaki Ide; Satoru Miyawaki; Takeshi Uno; Shuichiro Asano; Junichi Tanaka; Hiroshi Nakaguchi; Mitsuyoshi Sasaki; Mineko Murakami
FOLIA HISTOCHEMICA ET CYTOBIOLOGICA, 2008, [Reviewed] - Role of estrogen receptor beta in uterine stroma and epithelium: Insights from estrogen receptor beta(-/-) mice
Osamu Wada-Hiraike; Haruko Hiraike; Hiroko Okinaga; Otabek Imamov; Rodrigo P. A. Barros; Andrea Morani; Yoko Omoto; Margaret Warner; Jan- ke Gustafsson
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Nov. 2006, [Reviewed] - Analyses of the mechanism of intracellular transport and secretion of pituitary hormone, with an insight of the subcellular localization of pituitary hormone and its mRNA
Akira Matsuno; Akiko Mizutani; Susumu Takekoshi; Johbu Itoh; Hiroko Okinaga; Yuko Nishina; Koji Takano; Tadashi Nagashima; R. Yoshiyuki Osamura; Akira Teramoto
BRAIN TUMOR PATHOLOGY, 2006, [Reviewed] - Mechanisms of TRH-induced GH release (paradoxical response) in human somatotroph adenoma cells
H Okinaga; K Takano; S Hayashi; J Yasufuku-Takano; A Teramoto; T Fujita
ENDOCRINE JOURNAL, Dec. 2005, [Reviewed] - High risk of osteopenia and bone derangement in postsurgical patients with craniopharyngiomas, pituitary adenomas and other parasellar lesions
B Okinaga; A Matsuno; R Okazaki
ENDOCRINE JOURNAL, Dec. 2005, [Reviewed] - Establishment of stable GH3 cell line expressing enhanced yellow fluorescein protein-growth hormone fusion protein
A Matsuno; A Mizutani; J Itoh; S Takekoshi; T Nagashima; H Okinaga; K Takano; RY Osamura
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, Sep. 2005, [Reviewed] - 成長ホルモン分泌の可視化による分泌機構の解析
Sep. 2005, [Reviewed] - EYFP-GH fusion proteinの遺伝子を導入したGH3 stable cell lineの樹立
Sep. 2005, [Reviewed] - Glucocorticoid-induced osteoporosis
Y Tamura; H Okinaga; H Takami
BIOMEDICINE & PHARMACOTHERAPY, Nov. 2004, [Reviewed] - Clinical manifestations of familial medullary thyroid carcinoma
K Kameyama; H Okinaga; H Takami
BIOMEDICINE & PHARMACOTHERAPY, Jul. 2004, [Reviewed] - RET oncogene mutations in 75 cases of familial medullary thyroid carcinoma in Japan
K Kameyama; H Okinaga; H Takami
BIOMEDICINE & PHARMACOTHERAPY, Jul. 2004, [Reviewed] - Radiological and surgical management of thyroid neoplasms
H Takami; Y Ikeda; R Miyabe; H Okinaga; K Kameyama; N Fukunari
BIOMEDICINE & PHARMACOTHERAPY, Jul. 2004, [Reviewed] - Recent advances in the management of primary hyperparathyroidism
H Takami; Y Ikeda; H Okinaga; K Kameyama
ENDOCRINE JOURNAL, Aug. 2003, [Reviewed]
MISC
- 大学病院勤務の看護師における女性ホルモン値と労働形態の関連
奥田 佳奈子; 野村 恭子; 大野 真理子; 長澤 徹; 川崎 千春; 土谷 明子; 平池 春子; 大久保 孝義; 冲永 寛子
女性心身医学, Jun. 2019
(一社)日本女性心身医学会 - 大学病院勤務の看護師における女性ホルモン値と労働形態の関連
奥田 佳奈子; 野村 恭子; 大野 真理子; 長澤 徹; 川崎 千春; 土谷 明子; 平池 春子; 大久保 孝義; 冲永 寛子
女性心身医学, Jun. 2019
(一社)日本女性心身医学会 - 医学部附属病院で働く女性看護師における不定愁訴、血清ホルモン値と離職意向との関連
長澤 徹; 野村 恭子; 大野 真理子; 遠藤 通意; 土谷 明子; 平池 春子; 大久保 孝義; 冲永 寛子
日本衛生学雑誌, Feb. 2019
(一社)日本衛生学会 - 私立総合大学附属病院の女性看護師における職業性ストレスと身体症状との関連
吉岡 希; 野村 恭子; 浅山 敬; 竹之下 真一; 長澤 徹; 中田 善規; 平池 春子; 笹森 幸文; 土谷 明子; 大久保 孝義; 冲永 寛子
日本衛生学雑誌, Sep. 2018
(一社)日本衛生学会 - 女性の働きやすい職場についての尺度の開発
Jul. 2018 - 科学研究費若手種目に採択された医師研究者におけるメンターと精神疲労感との関連
田辺 杏由美; 野村 恭子; 竹之下 真一; 浅山 敬; 平池 春子; 笹森 幸文; 岡村 智教; 大久保 孝義; 沖永 寛子
日本衛生学雑誌, Mar. 2017
(一社)日本衛生学会 - 医療系総合大学と附属病院の教職員における職業性ストレスと不眠症との関連
菊山 智博; 野村 恭子; 竹之下 真一; 平池 春子; 笹森 幸文; 中田 善規; 大久保 孝義; 土谷 明子; 沖永 寛子
日本衛生学雑誌, Mar. 2017
(一社)日本衛生学会 - 医療系総合大学と附属病院の教職員における職業性ストレスと不定愁訴数との関連
吉岡 希; 野村 恭子; 竹之下 真一; 平池 春子; 笹森 幸文; 浅山 敬; 中田 善規; 大久保 孝義; 土谷 明子; 冲永 寛子
日本衛生学雑誌, Mar. 2017
(一社)日本衛生学会 - 腫瘍出血で発症,カテーテル塞栓術で状態安定化後に摘出した左副腎褐色細胞腫の組織像
江戸直樹; 斉藤光次; 山本敬洋; 子安洋輝; 小山英利奈; 戸塚美貴; 小川真澄; 内野卓也; 男澤悠貴; 根本かおり; 高橋諭; 真下大和; 藤巻祐子; 木村将貴; 盛田幸司; 近藤浩史; 笹島ゆう子; 近藤福雄; 冲永寛子; 石川敏夫
日本内分泌病理学会学術総会プログラム・抄録集, Sep. 2016 - 腫瘍破裂で後腹膜出血を来たし、カテーテル塞栓術で状態を安定化しえた褐色細胞腫の一例
江戸直樹; 山本敬洋; 戸塚美貴; 草薙真澄; 内野卓也; 男澤悠貴; 根本かおり; 高橋諭; 真下大和; 藤巻祐子; 盛田幸司; 近藤浩文; 石川敏夫; 江藤一弘; 冲永寛子; 藤森新
日本内分泌学会雑誌, Apr. 2016 - 出産後に発症し、病勢変動を認めた副甲状腺機能低下症の1例
FUJIMAKI YUKO; YAMAMOTO TADASHI; TOTSUKA MIKI; UCHINO TAKUYA; OTOKOZAWA YUKI; NEMOTO KAORI; TAKAHASHI SATOSHI; EDO NAOKI; MASHIMO YAMATO; MORITA KOJI; ISHIKAWA TOSHIO; ETO KAZUHIRO; OKINAGA HIROKO; FUJIMORI SHIN
日本内分泌学会雑誌, Oct. 2015 - 甲状腺ホルモン値とその変動による,血清尿酸値への影響の検討
UCHINO TAKUYA; TAKAHASHI SATOSHI; TOTSUKA MIKI; OZAWA YUKI; NEMOTO KAORI; EDO NAOKI; MASHIMO YAMATO; FUJIMAKI YUKO; MORITA KOJI; ISHIKAWA TOSHIO; ETO KAZUHIRO; OKINAGA HIROKO; FUJIMORI SHIN
日本内分泌学会雑誌, 01 Apr. 2015 - チアマゾールで発熱・肝障害を突発したバセドウ病・1型糖尿病
根本かおり; 戸塚美貴; 村野隼人; 吉野友佑; 太田樹; 男澤悠貴; 内野卓也; 真下大和; 盛田幸司; 石川敏夫; 石井新哉; 小野瀬裕之; 江藤一弘; 冲永寛子; 藤森新
日本内分泌学会雑誌, 20 Oct. 2014 - Antiproliferative Effects of 3-Methyl-2-Thiohydantoin, a Methimazole Metabolite That Activates Aryl Hydrocarbon Receptor, on MCF-7 Breast Cancer Cells
Satoshi Takahashi; Hiroko Okinaga; Maiko Murakami; Yamato Mashimo; Yuko Fujimaki; Koji Morita; Makoto Kinoshita; Shin Fujimori; Tamio Teramoto; Toshio Ishikawa
ENDOCRINE REVIEWS, Jun. 2014 - Empty sellaにGH産生腺腫を合併した先端巨大症の1例
内野卓也; 高橋諭; 村上舞子; 鈴木綾子; 真下大和; 藤巻祐子; 冲永寛子; 盛田幸司; 石川敏夫; 井下尚子; 山田正三; 江藤一弘; 木下誠; 藤森新
日本内分泌学会雑誌, Dec. 2013 - 高齢2型糖尿病の経過中に発症した劇症1型糖尿病にサイトメガロウイルス腸炎の関与が疑われた1例
真下大和; 吉村中行; 沼倉舞子; 前田朝美; 石川敏夫; 沖永寛子; 木下誠; 藤森新; 寺本民生; 江藤一弘
日本老年医学会雑誌, 25 Nov. 2012 - Molecular Morphology of Pituitary Cells, from Conventional Immunohistochemistry to Fluorescence Imaging (vol 16, pg 3618, 2011)
Akira Matsuno; Akiko Mizutani; Hiroko Okinaga; Koji Takano; So Yamada; Shoko M. Yamada; Hiroshi Nakaguchi; Katsumi Hoya; Mineko Murakami; Masato Takeuchi; Mutsumi Sugaya; Johbu Itoh; Susumu Takekoshi; R. Yoshiyuki Osamura
MOLECULES, Oct. 2012 - 反復性低血糖発作に外因性インスリンの関与が疑われたがscatchard解析によりインスリン自己免疫症候群の診断に至った1症例
沼倉舞子; 小片展之; 吉村中行; 真下大和; 藤巻祐子; 前田朝美; 石川敏夫; 冲永寛子; 木下誠; 藤森新; 寺本民生; 江藤一弘
東京内科医会会誌, 31 Dec. 2011 - Refeeding症候群に伴う低Mg血症により低Ca血症をきたした一例
真下大和; 石川敏夫; 吉村中行; 沼倉舞子; 藤巻祐子; 前田朝美; 小片展之; 冲永寛子; 木下誠; 藤森新; 寺本民生; 江藤一弘
日本内分泌学会関東甲信越支部学術集会プログラム抄録集, 2010 - 測定干渉因子による高TSH血症が判明するまで苦慮した1例
武岡 陽子; 真下 大和; 安田 大二郎; 吉村 中行; 草野 淳; 前田 朝美; 石川 敏夫; 冲永 寛子; 木下 誠; 寺本 民生
日本内科学会関東地方会, Nov. 2009
日本内科学会-関東地方会 - Three-dimensional imagings of the intracellular localization of mRNA and its transcript using nanocrystal (Quantum dot) and confocal laser scanning microscopy techniques
Akira Matsuno; Akiko Mizutani; Susumu Takekoshi; R. Yoshiyuki Osamura; Johbu Itoh; Fuyuaki Ide; Satoru Miyawaki; Takeshi Uno; Shuichiro Asano; Junichi Tanaka; Hiroshi Nakaguchi; Mitsuyoshi Sasaki; Mineko Murakami; Hiroko Okinaga
Quantum Dots: Research, Technology and Applications, 01 Apr. 2008 - 甲状腺中毒症を呈し,穿刺細胞診で診断し得た,甲状腺アスペルギルス感染症の1例
仁科祐子; 盛田幸司; 高野幸路; 中屋宗雄; 佐野真幸; 鈴木尚宜; 和泉梢; 冲永寛子; 林菜子; 林周兵; 森典子; 岡崎具樹; 藤田敏郎
日本内分泌学会雑誌, Sep. 2005 - EYFP‐GH fusion proteinの遺伝子を導入したGH3 stable cell lineの確立と調節性分泌経路の検討
松野彰; 水谷晃子; 伊東丈夫; 竹腰進; 沖永寛子; 高野幸路; 長島正; 長村義之
日本脳神経外科学会総会抄録集(CD-ROM), 2005
Lectures, oral presentations, etc.
- ステロイド点眼により視床下部ー下垂体ー副腎皮質(HPA)系に抑制を来した副腎偶発腫の1例
Nov. 2010 - 下垂体前葉細胞の電気整理、腫瘍発生、および開口分泌機構について
Oct. 2010