Konomi Togo

Faculty of Health and Medical Science,Department of Medical Course,Medical Engineering CourseProfessor
Graduate School of Information Sciences,Major of Information SciencesProfessor
Last Updated :2025/10/29

■Researcher basic information

Degree

  • Ph.D. in Medicine, Hyogo Medical University, Mar. 2016
  • Ph.D. in Science and Engineering, Hosei University, Mar. 2020

Research Keyword

  • CRRT

Field Of Study

  • Life sciences, Biomedical engineering, CRRT, ECMO

■Career

Career

  • Apr. 2025 - Present
    Teikyo Heisei University, Faculty of Health and Medical Science Department of Medical Course
  • Apr. 2024 - Present
  • Apr. 2021 - Present
  • Apr. 2021 - Present
    Teikyo Heisei University, Faculty of Health and Medical Science Department of Medical Course
  • Apr. 2016 - Mar. 2021
    Teikyo Heisei University, Faculty of Health and Medical Science, Department of Medical Course
  • Apr. 2012 - Mar. 2016
  • Apr. 2008 - Mar. 2012
    Osaka City University, University Hospital, Medical School
  • Dec. 2006 - Mar. 2008
  • Oct. 2005 - Dec. 2006
  • Mar. 2005 - Sep. 2005
    Kagawa University, University Hospital, Faculty of Medicine

Educational Background

  • Apr. 2017 - Mar. 2020, Hosei University, Graduate School
  • Apr. 2012 - Mar. 2016, Hyogo College of Medicine, Graduate School
  • Apr. 2010 - Mar. 2012, Osaka City University

Member History

  • Jan. 2023 - Present
  • Apr. 2022 - Present
  • Apr. 2018 - Present

■Research activity information

Award

  • Oct. 2017
  • Nov. 2016

Paper

  • ダイアライザの基本特性と選択の考え方－ダイアライザの生体適合性－　　　　　　　　　　　　　　　
    Sep. 2025, [Invited]
  • Investigating optimal drainage cannula for venovenous extracorporeal membrane oxygenation: impact of side holes on blood oxygenation – an in vitro study
    Konomi Togo
    Journal of Artificial Organs, 20 Aug. 2025
    Venovenous extracorporeal membrane oxygenation (VV ECMO) relies on effective blood drainage, and cannula design plays a crucial role in optimizing blood oxygenation. Recirculation, where oxygenated blood returns to the drainage cannula without systemic circulation, can negatively impact ECMO efficacy. It was hypothesized that drainage cannulae with a longer side hole portion would reduce recirculation and improve blood oxygenation. This in vitro study investigated the impact of the length of the side hole portion and the intervals of the side holes on blood oxygenation in a simulated VV ECMO circuit. Five cannulae were prepared with the following side holes: (a) 1-cm intervals from the tip to 5 cm; (b) 1-cm intervals from the tip to 10 cm; (c) 1-cm intervals from the tip to 15 cm; (d) 3-cm intervals from the tip to 15 cm; and e) 5-cm intervals from the tip to 15 cm. With blood drained from the right atrium and returned to the superior vena cava, recirculation rates and PaO2 at 150 s after ECMO initiation (descending PaO2 order) were: (c) 32 ± 1% and 160 ± 4 mmHg; (d) 35 ± 1% and 149 ± 5 mmHg; (b) 38 ± 1% and 139 ± 5 mmHg; (e) 39 ± 1% and 133 ± 4 mmHg; and (a) 57 ± 3% and 94 ± 7 mmHg. These findings suggest that cannulae with a longer side hole portion may optimize blood oxygenation by reducing recirculation. Furthermore, shorter side hole portions on drainage cannulae are not recommended for VV ECMO.
    DOI URL
  • ヘモダイアフィルタの生体適合性　　　　　　　　　　　　　　　
    Jul. 2023, [Invited]
  • Dexamethasone and ketorolac compare with ketorolac alone in acute renal colic: A randomized clinical trial.
    Konomi Togo; Shohei Ono; Ryota Matsui; Jun Watanabe
    The American journal of emergency medicine, 14 Sep. 2022, [Reviewed]
    DOI URL
  • Particulates formed in dialysis fluid: effect of silica in tap water
    Motoyuki Imai; Masahito Yamamoto; Konomi Togo; Akihiro C. Yamashita
    RENAL REPLACEMENT THERAPY, Sep. 2022, [Reviewed]
    DOI URL
  • Particulates formed in online prepared substitution fluid-Effect of acetic acid cleaning on endotoxin retentive filters.
    Motoyuki Imai; Masahito Yamamoto; Konomi Togo; Akihiro C Yamashita
    Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy, 12 Apr. 2022, [Reviewed]
    INTRODUCTION: There is no standard for insoluble particulate matters in dialysate. We evaluated the insoluble particulate matters in online prepared substitution fluid. METHODS: We evaluated particle diameters and constituent elements of particles in online prepared substitution fluid and the final endotoxin retentive filter (ETRF). RESULTS: The measurement results with particles in the online prepared substitution fluid and particles attached to the final ETRF revealed that Ca-containing particles accounted for 11 particles and Si-containing particles accounted for 19 particles of 30 particles detected in the online prepared substitution fluid and the final ETRF. CONCLUSION: We presume that insoluble particulates in online prepared substitution fluid were Ca and Mg precipitated from dialysate and Si precipitated from dialysis water. Even if two ETRFs were connected in series, these particles were formed in the final ETRF.
    DOI URL
  • 臨床工学技士養成校における学生が希望するオンライン授業の形式の検討 －学生アンケート集計結果による考察－　　　　　　　　　　　　　　　
    Mar. 2022, [Reviewed]
  • Blood compatibility in various hemodialysis membrane materials: A Review　　　　　　　　　　　　　　　
    Konomi Togo; Akihiro C. Yamashita
    Oct. 2021, [Reviewed]
  • ダイアライザ，ヘモダイアフィルタの生体適合性／クリニカルエンジニアリング Vol.32 No.5 2021年5月号　　　　　　　　　　　　　　　
    May 2021, [Invited]
  • Comparison of Blood Compatibility in Various Membrane Materials for Continuous Renal Replacement Therapy
    Konomi Togo; Masahito Yamamoto; Motoyuki Imai; Keiichi Akiyama; Akihiro C. Yamashita
    Therapeutic Apheresis and Dialysis, 21 Jun. 2019, [Reviewed]
    URLDOI URL
  • Optimal drainage cannula position in dual cannulation for veno-venous extracorporeal membrane oxygenation.
    Konomi Togo; Yoshiaki Takewa; Nobumasa Katagiri; Yutaka Fujii; Akihiro C Yamashita; Eisuke Tastumi
    The International journal of artificial organs, Dec. 2018
    INTRODUCTION:: Recently, the use of veno-venous extracorporeal membrane oxygenation for adult patients with severe acute respiratory failure has increased. We previously investigated the optimal return cannula position; however, the optimal drainage cannula position has not yet been fully clarified. The aim of this study was to investigate the optimal drainage cannula position. METHODS:: Veno-venous extracorporeal membrane oxygenation was performed in four adult goats (mean body weight 59.6 ± 0.6 kg). The position of the drainage cannula was varied among the right atrium, the upper inferior vena cava, and the lower inferior vena cava, whereas the position of the return cannula was fixed in the superior vena cava. The recirculation fraction and arterial oxygen saturation and pressure (SaO2, PaO2) were measured in all drainage cannula positions. RESULTS:: In the lower inferior vena cava drainage cannula position, the recirculation fraction was the lowest. In the lower inferior vena cava, upper inferior vena cava, and right atrium drainage cannula positions at 3 L/min, SaO2 and PaO2 after 20 min were 92.9% ± 4.9% and 75.1 ± 26.0 mm Hg, 99.5% ± 0.5% and 113.8 ± 20.9 mm Hg, and 93.8% ± 6.2% and 91.9 ± 17.7 mm Hg, respectively. CONCLUSION:: With respect to blood oxygenation, the optimal position for the drainage cannula was the upper inferior vena cava. These findings suggested that blood from the superior vena cava, inferior vena cava, and hepatic vein was most efficiently drained in the upper inferior vena cava cannula position.
    DOI URL
  • Comparison of biocompatibility in polysulfone dialysis membranes with different sterilization.　　　　　　　　　　　　　　　
    Konomi TOGO; Masahito YAMAMOTO; Takahisa ONO; Motoyuki IMAI; Keiich AKIYAMA; Kunio EBINE; Akihiro C; YAMASHITA
    Hemodialysis International (Epub ahead of print), 2018
  • Comparison of biocompatibility in cellulose triacetate dialysis membranes with homogeneous and asymmetric structures.　　　　　　　　　　　　　　　
    Konomi TOGO; Masahito YAMAMOTO; Motoyuki IMAI; Keiich AKIYAMA; Akihiro C
    Renal Replacement Therapy, 2018
  • Novel temporary left ventricular assist system with hydrodynamically levitated bearing pump for bridge to decision: Initial preclinical assessment in a goat model
    Satoru Kishimoto; Yoshiaki Takewa; Tomonori Tsukiya; Toshihide Mizuno; Kazuma Date; Hirohito Sumikura; Yutaka Fujii; Kentaro Ohnuma; Konomi Togo; Nobumasa Katagiri; Noritsugu Naito; Yuichiro Kishimoto; Yoshinobu Nakamura; Motonobu Nishimura; Eisuke Tatsumi
    Journal of Artificial Organs, 2018
    DOI URL
  • Novel temporary left ventricular assist system with hydrodynamically levitated bearing pump for bridge to decision: initial preclinical assessment in a goat model
    Satoru Kishimoto; Yoshiaki Takewa; Tomonori Tsukiya; Toshihide Mizuno; Kazuma Date; Hirohito Sumikura; Yutaka Fujii; Kentaro Ohnuma; Konomi Togo; Nobumasa Katagiri; Noritsugu Naito; Yuichiro Kishimoto; Yoshinobu Nakamura; Motonobu Nishimura; Eisuke Tatsumi
    Journal of Artificial Organs, 12 Sep. 2017, [Reviewed]
    DOI URL
  • 学内講義と学内実習の臨床実習に対する有用性−学生アンケートより−
    2017
    URL
  • Evaluation of blood oxygenation and CO2 removal using a double-lumen catheter for adult extracorporeal membrane oxygenation in animal experiment
    Togo Konomi; Fujii Yutaka; Takewa Yoshiaki; Katagiri Nobumasa; Kamada Kazuya; Tastumi Eisuke
    Japanese journal of extra-corporeal technology, 2017

    The number of cases of veno-venous extracorporeal membrane oxygenation (VV ECMO) using the Avalon double-lumen catheter (Avalon-DLC) has been increasing. The catheter has many merits, such as less bleeding and reduced risk of infection. However, the diameters of the drainage and return lumens of the Avalon-DLC are smaller than those of cannulae for dual cannulation. Therefore, sufficient bypass flow may not be achieved, and blood oxygenation may be insufficient. The purpose of this study was to investigate whether VV ECMO using an Avalon-DLC can provide sufficient gas exchange performances.

    An Avalon-DLC was inserted into eight adult goats (body weight 60.2±0.4 kg), and VV ECMO was performed. The arterial oxygen saturation (SaO2), arterial oxygen partial pressure (PaO2), and arterial partial pressure of carbon dioxide (PaCO2) were measured under only ECMO support without native respiration.

    When the bypass flow rates were higher than 2L/min, the SaO2 was maintained at greater than 80%, and the PaCO2 was approximately within the normal range. At 20 minutes after the support, PaO2 was 23.7±1.2, 46.3±3.2, 91.9±9.7, and 159.6±29.8mmHg at 1, 2, 3, and 4L/min, respectively.

    VV ECMO using the Avalon-DLC could obtain sufficient gas exchange.

    DOI URL
  • Effects of feeding state on anticoagulation in adult goats treated with warfarin
    Kazuma Date; Satoru Kishimoto; Yutaka Fujii; Konomi Togo; Yukihide Kakuta; Toshihide Mizuno; Tomonori Tsukiya; Yoshiaki Takewa; Takashi Nishimura; Minoru Ono; Eisuke Tatsumi
    JOURNAL OF ARTIFICIAL ORGANS, Sep. 2016
    DOI URL
  • Impact of bypass flow rate and catheter position in veno-venous extracorporeal membrane oxygenation on gas exchange in vivo
    Konomi Togo; Yoshiaki Takewa; Nobumasa Katagiri; Yutaka Fujii; Satoru Kishimoto; Kazuma Date; Yuji Miyamoto; Eisuke Tatsumi
    JOURNAL OF ARTIFICIAL ORGANS, Jun. 2015
    DOI URL
  • Assessment of the clinical benefits of remote monitoring of cardiac-implanted devices: A single-center study in Japan
    Konomi Togo; Masahiko Takagi; Kentaro Suzuki; Keiko Maeda; Hiroaki Tatsumi; Kazuhide Takeuchi
    Journal of Arrhythmia, 2013
    DOI URL
  • Assessment of Outpatients' Waiting Time and the Intervais to Find out Arrhythmic Events or Abnormal Device Performance Using Remote Home Monitoring System
    Konomi Togo; Kentaro Suzuki; Keiko Maeda; Hiroaki Tatsumi; Masahiko Takagi
    Journal of Arrhythmia, 2011, [Reviewed]
    DOI URL

MISC

Lectures, oral presentations, etc.

  • 閉鎖回路における異なる膜型人工肺2種のマイクロバブル除去能力の実験的検討　　　　　　　　　　　　　　　
    12 Oct. 2025
  • 生体適合性を考慮した血液浄化器の選択　　　　　　　　　　　　　　　
    28 Sep. 2025, [Invited]
  • Implementation and challenges of shared decision-making education in renal replacement therapy within clinical engineering training programs　　　　　　　　　　　　　　　
    20 Aug. 2025
  • Investigation of the Impact of Superior and Inferior Vena Cava Hemodynamics on Oxygenation Capacity under VV ECMO Management
    Konomi Togo
    08 Jun. 2025
  • Effect of Changes in the SVC/IVC Blood Flow Ratio on ECMO Oxygenation
    Konomi Togo
    The 62nd Annual Meeting of the Japanese Society for Artificial Organs (JSAO) held in Utsunomiya, Tochigi, at Light Cube Utsunomiya, Nov. 2024
  • INFLUENCE OF LENGTH OF SIDE HOLE PORTION AND INTERVAL OF SIDE HOLES IN DRAINAGE CANNULAE FOR V-V ECMO: EFFECT ON RECIRCULATION RATE AND BLOOD OXYGENATION
    09 Sep. 2024
  • Nutritional Status Assessment and Selection of Blood Purification Therapy in Dialysis Patients　　　　　　　　　　　　　　　
    Konomi Togo
    The 39th Annual Meeting of the Japanese Society for Medical Engineering and Therapeutics, May 2023, [Invited]
  • 臨床工学技士による新規医療機器・システム開発 臨床工学技士による新規医療機器開発 体外設置型補助人工心臓およびポータブルECMOシステムの開発に携わった経験から　　　　　　　　　　　　　　　
    Nov. 2022, [Invited]
  • 待ったなしの働き方改革 各職種でのタスクシフトの現状と課題 臨床工学技士養成校教員の立場から　　　　　　　　　　　　　　　
    Nov. 2022, [Invited]
  • 血液浄化器の生体適合性のin vitro評価　　　　　　　　　　　　　　　
    May 2022, [Invited]
  • ヘモダイアフィルタの生体適合性　　　　　　　　　　　　　　　
    May 2022, [Invited]
  • 臨床工学技士養成校における最適なオンライン授業の形式　　　　　　　　　　　　　　　
    May 2021
  • 臨床工学技士養成校における shared decision making 教育の取り組み　　　　　　　　　　　　　　　
    May 2021
  • 人工臓器治療における看護師に求められる役割　　　　　　　　　　　　　　　
    Nov. 2020
  • 臨床工学養成校におけるオンライン授業に関する状況と問題点　　　　　　　　　　　　　　　
    Nov. 2020
  • 臨床工学教育におけるshared decision makingの概念　　　　　　　　　　　　　　　
    Nov. 2020, [Invited]
  • Comparison of biocompatibility in polysulfone dialysis membranes with different sterilization　　　　　　　　　　　　　　　
    Mar. 2019
  • Comparison of biocompatibility in cellulose triacetate dialysis membranes with symmetric and asymmetric structures　　　　　　　　　　　　　　　
    2018
  • Comparison of biocompatibility in polysulfone dialysis membranes with different sterilization　　　　　　　　　　　　　　　
    2018
  • 滅菌方法が異なるダイアライザにおける生体適合性の比較　　　　　　　　　　　　　　　
    2018
  • 補助人工心臓やECMO、PCPSなどの補助循環における出口部感染ケア　　　　　　　　　　　　　　　
    2017
  • 新規ポリマーコーティングを施した抗血栓性材料の特性評価　　　　　　　　　　　　　　　
    2017
  • Comparison of biocompatibility in polysulfone membranes between polyvinylpyrrolidone and hydrophilic polymer coating (with and without NV polymer coating)　　　　　　　　　　　　　　　
    2017
  • 成人extracorporeal membrane oxygenation（ECMO）用ダブルルーメンカテーテル使用に おける注意点　　　　　　　　　　　　　　　
    2016
  • Comparison of gas exchange in single and dual cannulation for adult extracorporeal membrane oxygenation in animal experiment　　　　　　　　　　　　　　　
    2016
  • COMPARISON OF BLOOD OXYGENATION IN SINGLE AND DUAL CANNULATION FOR ADULT EXTRACORPOREAL MEMBRANE OXYGENATION　　　　　　　　　　　　　　　
    2016
  • デュアルカニュレーションextracorporeal membrane oxygenationにおける最適な脱血カニューレの位置の検討　　　　　　　　　　　　　　　
    2016
  • 成人ECMO用ダブルルーメンカテーテルのin vivoにおける性能評価　　　　　　　　　　　　　　　
    2015
  • 成人ECMO用ダブルルーメンカテーテルの使用経験　　　　　　　　　　　　　　　
    2015
  • 成人ECMO用ダブルルーメンカテーテル（Avalon Elite Bicaval Dual Lumen catheter）の生体における酸素化評価　　　　　　　　　　　　　　　
    2015
  • The important point that we should be careful for effective single-cannulation of venovenous extracorporeal membrane oxygenation　　　　　　　　　　　　　　　
    2015
  • 国立循環器病研究センターのトレーニングセンターにおける医療機器トレーニングの実際　　　　　　　　　　　　　　　
    2015
  • The Requirements That We Should Be Careful For Effective Single-cannulation Of Venovenous Extracorporeal Membrane Oxygenation　　　　　　　　　　　　　　　
    2015
  • Comparison of blood oxygenation between the double lumen catheter and the dual cannulation for Venovenous Extracorporeal Membrane Oxygenation　　　　　　　　　　　　　　　
    2015
  • Comparison of gas exchange at the proper and the improper direction of the double lumen catheter for adult Venovenous Extracorporeal Membrane Oxygenation　　　　　　　　　　　　　　　
    2015
  • The essential point that we should be careful for effective single-cannulation of venovenous ECMO　　　　　　　　　　　　　　　
    2015
  • 成人ECMO用ダブルルーメンカテーテルを用いての酸素化評価　　　　　　　　　　　　　　　
    2015
  • THE NECESSARY POINT THAT WE SHOULD BE CAREFUL FOR EFFECTIVE SINGLE-CANNULATION OF VENOVENOUS ECMO　　　　　　　　　　　　　　　
    2015
  • 成人ECMO用ダブルルーメンカテーテル選択時の留意点　　　　　　　　　　　　　　　
    2015
  • VVECMOの送脱血管ポジショニングの最適化に関する検討　　　　　　　　　　　　　　　
    2014
  • Utility operating method to achieve effective veno-venous extracorporeal membrane oxygenation　　　　　　　　　　　　　　　
    2014
  • PRACTICAL TECHNIQUE OF VENO-VENOUS EXTRACORPOREAL MEMBRANE OXYGENATION FOR EFFECTIVE OXYGENATION AND CARBON DIOXIDE REMOVAL　　　　　　　　　　　　　　　
    2014
  • VVECMOを効率よく行うには？カニュレーション位置からの検討　　　　　　　　　　　　　　　
    2013
  • VVECMOを効率良く行うためのカニュレーション位置の検討　　　　　　　　　　　　　　　
    2013
  • Practical operating method of veno-venous extracorporeal membrane oxygenation aiming for effective oxygenation　　　　　　　　　　　　　　　
    2013
  • VVECMOを効率良く行うためのバイパス流量と送血位置の検討　　　　　　　　　　　　　　　
    2013
  • Useful operating method of veno-venous extracorporeal membrane oxygenation aiming for effective oxygenation　　　　　　　　　　　　　　　
    2013

Affiliated academic society

  • Jan. 2026 - Present
    The American Society of ExtraCorporeal Technology　　　　　　　　　　　　　　　
  • Sep. 2021 - Present
    日本心筋保護研究会　　　　　　　　　　　　　　　
  • Apr. 2020 - Present
    Extracorporeal Life Support Organization (ELSO)　　　　　　　　　　　　　　　
  • JAPANESE SOCIETY FOR ARTIFICIAL ORGANS　　　　　　　　　　　　　　　

Research Themes

Academic Contribution Activities

  • Dialysis treatment, In vitro study, and Anticoagulant activity of Polysulfone- Polyacrylamide based-blend membranes　　　　　　　　　　　　　　　
    Peer review
    10 Aug. 2024
  • Addressing flow rate and circuit pressure drop issues in small dogs using an arterial cannula as a hemodialysis catheter　　　　　　　　　　　　　　　
    Peer review
    02 Jul. 2024
  • Development and evaluation of user friendly modelled approach for sustainable polymer membranes for advanced hemodialysis　　　　　　　　　　　　　　　
    Peer review
    27 Jun. 2024
  • Polyuria in a patient with novel coronavirus infection undergoing extracorporeal membrane oxygenation　　　　　　　　　　　　　　　
    Peer review
    21 Feb. 2024
  • Preparation and hemocompatibility of novel antioxidant-modified polyethersulfone membranes as red blood cell thrombosis inhibitors　　　　　　　　　　　　　　　
    Peer review
    08 Nov. 2023
  • A comparison of platelet adhesion and activation properties between vitamin E-coated and hydrophilic polymer-coated polysulfone hemodialyzer membranes　　　　　　　　　　　　　　　
    Peer review
    31 May 2022
  • Replication of fouling in vitro in hollow fiber dialyzers by albumin immobilization　　　　　　　　　　　　　　　
    Peer review
    08 Sep. 2021
  • Preparation of modified polysulfone material decorated by sulfonated citric chitosan for hemodialysis and its hemocompatibility　　　　　　　　　　　　　　　
    Peer review
    06 Apr. 2021
  • Effect of CRRT combined with low-flow ECMO on canines with ARDS and hypercapnia　　　　　　　　　　　　　　　
    Peer review
    08 Aug. 2020
  • High grade acquired von Willebrand syndrome in patients treated with percutaneous cardiopulmonary support system　　　　　　　　　　　　　　　
    Peer review
    12 Nov. 2017
  • Acute respiratory distress syndrome (ARDS) treated successfully by veno-venous extracorporeal membrane oxygenation (ECMO) in a nearly drowned patient　　　　　　　　　　　　　　　
    Peer review
    2016 - 2016

■University education and qualification information

Qualifications, licenses

  • nurse
  • Clinical Engineer
  • Certified Hemodialysis Technician/Technologist