Kim Honsong

Faculty of Pharmaceutical Sciences,Department of Pharmaceutical SciencesLecturer
Last Updated :2025/10/07

■Researcher basic information

Research Keyword

  • primary cilia
  • microtubule
  • CG-NAP/AKAP450

Field Of Study

  • Life sciences, Developmental biology, Cell migration, Organogenesis
  • Life sciences, Cell biology, Primary ciliogenesis

■Career

Career

  • Apr. 2015 - Present
    Teikyo Heisei University, Faculty of Pharmaceutical Sciences, Assistant Professor
  • Apr. 2009 - Mar. 2014
    Kwansei Gakuin University
  • Apr. 2007 - Mar. 2009
    RIKEN, CDB

Educational Background

  • Apr. 2004 - Mar. 2007, Kobe University
  • Apr. 2002 - Mar. 2004, Kobe University

■Research activity information

Paper

Research Themes

  • Neuropeptide regulation of organogenesis through cell surface FoF1-ATP synthase
    Grant-in-Aid for Scientific Research (C)
    Kwansei Gakuin University
    01 Apr. 2022 - 31 Mar. 2025
  • CG-NAP function in ciliogenesis through regulation of centriolar satellite formation
    Grant-in-Aid for Scientific Research (C)
    Teikyo Heisei University
    01 Apr. 2019 - 31 Mar. 2022
  • Role of a ribosomal protein in the ADAMTS protease pathway regulating cell migration
    Grant-in-Aid for Challenging Exploratory Research
    Kwansei Gakuin University
    01 Apr. 2014 - 31 Mar. 2017
    MIG-17, an ADAMTS metalloprotease controls migration of gonadal distal tip cells (DTCs) through regulation of extracellular matrix in C. elegans. In the present study, we asked why the mutation in a ribosomal protein RPL-20(G82R) can suppress the DTC migration defect in the mig-17 mutants. Although we could not reach a clear understanding of the mechanism, we found that RPL-20(G82R) does not affect the regulatory mechanism of translational initiation. We also showed that RPL-20(G82R) is not secreted, but that it appears to act through unknown secreted proteins to suppress the mig-17 defects. We found that the RPL-20 activity is especially important in the intestine for the suppression to occur.
  • Analysis of flp-10 that controls organogenesis in c.elegans
    Grant-in-Aid for Challenging Exploratory Research
    Kwansei Gakuin University
    01 Apr. 2013 - 31 Mar. 2015
    An FMRFamide has Phe-Met-Arg-Phe-NH2 in its carboxyl terminus. These peptides are known to be involved in regulation of neuronal activities. We found that the C.elegans FLP-10C peptide, a part of the proteolytic fragment of FMRFamide like peptide (FLP), controls tip cell migration of U-shaped gonads in C.elegans. This suggests a novel function of this peptide in regulating gonadogenesis. We identified a protein in the worm lysate specifically co-precipitated with the FLP-10C peptide in a pull-down assay using the biotinylated peptide. LC/MS/MS analysis revealed that the specific protein corresponded to the product of H28O16.1. H28O16.1 encodes the alpha subunit of mitochondrial ATP synthase. Interestingly, there are some reports that the mitochondrial ATP synthase is also expressed in the plasma membrane. These results suggest that H28O16.1 could be the receptor for the FLP-10C peptide to regulate gonadogenesis.