Takuya Ayabe
| Faculty of Health Care and Medical Sports,Department of Nursing | Professor |
Last Updated :2025/10/07
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Career
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Paper
- Proposal for individual treatment by tubal occlusion factor based on the results of salpingoscopic salpingoplasty
Ippei Nakagawa; Mana Hirano; Rintaro Kishimoto; Akinori Kayama; Tsuyoshi Fujino; Yasundo Miyazaki; Akihiko Suenaga; Hiroshi Seto; Takuya Ayabe; Kazunori Nagasaka
Journal of Obstetrics and Gynaecology Research, 05 Jun. 2024, [Reviewed]
Abstract
Aim
As a treatment for tubal infertility, falloposcopic tuboplasty (FT) is one of the options for patients who wish to conceive naturally. Based on the results of FT, we propose an appropriate time of transitioning to assisted reproductive technology (ART) for tubal infertility.
Objects and Methods
We examined the outcomes of cases of tubal infertility during the period from June 1999 through March 2021 who were performed tuboplasty at our hospital using the FT catheter system under laparoscopy.
Results
The number of treated cases was 828. There were 243 cases of endometriosis and 119 cases of genital chlamydial infection. By FT, 712 cases (86.0%) were successfully recanalized. Of the 712 cases, 189 conceived naturally (26.5%) and miscarriages were 23 cases (12.2%), ectopic pregnancies were 8 cases (4.2%). The mean duration from FT to pregnancy was 6.5 months in natural pregnancy group, 90% of them were pregnant within 14 months. In endometriosis cases, the pregnancy rate after FT did not change significantly among clinical stage.
Conclusions
Even when the fallopian tube was recanalized by FT, if the couple is unable to conceive naturally, they had better to consider switching to ART at about 14 months. When the couples with endometriosis consider switching to ART, we suggest deciding without considering the rASRM stage. - Ulipristal acetate simultaneously provokes antiproliferative and proinflammatory responses in endometrial cancer cells.
Ranka Kanda; Yuko Miyagawa; Osamu Wada-Hiraike; Haruko Hiraike; Kazunori Nagasaka; Eiji Ryo; Tomoyuki Fujii; Yutaka Osuga; Takuya Ayabe
Heliyon, Jan. 2022
Ulipristal acetate (UPA), a selective progesterone receptor modulator, is used for the treatment of uterine fibroids and selectively inhibits the proliferation and inflammation of leiomyoma cells. As few studies have focused on the molecular biological mechanism of UPA in Ishikawa endometrial cancer cells, we aimed to identify the effects of UPA on these cells. Ishikawa cells were treated with different concentrations of UPA. Cell viability and colony formation assays were performed to assess the growth of cancer cells, whereas invasion and migration assays were used to measure cell motility and invasiveness. Western blotting, caspase 3/7 assay, TUNEL assay, and flow cytometry were performed to analyze apoptosis. Moreover, expression levels of the proinflammatory cytokines oncostatin M, its receptor, interleukin 6, and interleukin 8 were examined using quantitative real-time PCR. UPA decreased cell viability and growth, thereby inhibiting cell migration and invasion via induction of apoptosis. Contrary to expectation, stand-alone application of UPA increased the expression of the proinflammatory cytokines but concomitant use of UPA and the estrogen receptor antagonist ICI 182,720 decreased it. These data revealed a novel dual role of UPA: It could attenuate cell growth via activation of apoptosis while simultaneously provoking the activation of proinflammatory cytokines in endometrial cancer cells. These indicate that the combination of UPA and an estrogen receptor antagonist may be useful in suppressing the secretion of proinflammatory cytokines by UPA alone. - 卵巣明細胞腺癌におけるNicotinamide N-methyltransferase(NNMT)発現の臨床病理学的意義
Jul. 2021 - FMAMレコーダーを使用して胎動を計測した腹壁破裂の1例
Jun. 2021 - FMAM recorderによって胎動を計測していた18trisomyの1例
Jun. 2021 - 当院での妊婦の風疹スクリーニングおよび感染診断検査に関する後方視的検討
May 2021 - 子宮体癌に対する腹腔鏡下子宮全摘術での傍大動脈リンパ節の術中超音波断層法検査
Apr. 2021 - 経腟超音波エラストグラフィーを用いた子宮内膜ポリープと子宮粘膜下筋腫との鑑別診断
Apr. 2021 - 妊娠初期に判明した子宮頸部腺癌IIB期に対し、ベバシズマブ併用術前化学療法(NAC)後に広汎子宮全摘出術を施行した1例
Apr. 2021 - 帝王切開による子宮頸管への損傷が原因と考えられる頸管無力症に対し、開腹頸管縫縮術を施行し生児を得た2例
Mar. 2021 - 出生後に成長ホルモン分泌不全型低身長と診断された児における胎動占有割合の検討 FMAM recorderでの計測
Mar. 2021 - リトドリン塩酸塩の経口投与が胎動に及ぼす影響について fetal movement acceleration measurement recorder(FMAM recorder)を用いて
Mar. 2021 - 出生前から多職種によりカウンセリングを行った軟骨無形成症の1例
Jan. 2021 - 進行卵巣癌に対する脱ユビキチン化酵素阻害剤bAP15およびVLX1570の抗腫瘍効果についての基礎的検討
Jan. 2021 - 当科においてオラパリブ維持療法を施行した卵巣癌、卵管癌、腹膜癌の後方視的検討
Jan. 2021 - Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-like Cells using the Three-dimensional Co-culture System, NICO-1.
Yuko Miyagawa; Kazunori Nagasaka; Kaoru Yamawaki; Yutaro Mori; Tatsuya Ishiguro; Kei Hashimoto; Ryoko Koike; Siho Fukui; Takeru Sugihara; Takayuki Ichinose; Haruko Hiraike; Koichiro Kido; Koji Okamoto; Takayuki Enomoto; Takuya Ayabe
Journal of visualized experiments : JoVE, 05 Dec. 2020
Cancer stem cells (CSCs) reside in a supportive niche, constituting a microenvironment comprised of adjacent stromal cells, vessels, and extracellular matrix. The ability of CSCs to participate in the development of endothelium constitutes an important characteristic that directly contributes to the general understanding of the mechanisms of tumorigenesis and tumor metastasis. The purpose of this work is to establish a reproducible methodology to investigate the tumor-initiation capability of ovarian cancer stem cells (OCSCs). Herein, we examined the neovascularization mechanism between endothelial cells and OCSCs along with the morphological changes of endothelial cells using the in vitro co-culture model NICO-1. This protocol allows visualization of the neovascularization step surrounding the OCSCs in a time course manner. The technique can provide insight regarding the angiogenetic properties of OCSCs in tumor metastasis. - 塩酸リトドリン投与による胎児脈圧の変化 Dual Doppler法による脈波伝播速度測定
Nov. 2020 - 帝王切開が原因で頸管無力症となったと推測された症例に開腹頸管縫縮術を施行した1例
Nov. 2020 - 軽度脳室拡大を認め21 trisomyと診断された2例
Nov. 2020 - 腹腔鏡下子宮体がん傍大動脈リンパ節郭清術アプローチごとの治療成績についての検討
Nov. 2020 - 腹腔鏡下子宮体癌根治術における傍大動脈リンパ節の術中超音波検査
Nov. 2020 - 進行卵巣癌疑い症例に対する審査腹腔鏡手術時の術中超音波検査の有用性について
Nov. 2020 - 当院における子宮脱に対する腹腔鏡下Native tissue repairを施行した症例の検討
Nov. 2020 - 40代修練医師の腹腔鏡技術認定医取得に向けたTLH技術修練についての検討
Nov. 2020 - 当科で経験した子宮および付属器に同時進展する癌肉腫2症例についての検討
Oct. 2020 - 当科で経験した子宮および付属器に同時進展する癌肉腫2症例についての検討
Oct. 2020 - Liver disease in pregnancy.
Yukifumi Sasamori; Atsushi Tanaka; Takuya Ayabe
Hepatology research : the official journal of the Japan Society of Hepatology, Sep. 2020
Development of liver diseases during pregnancy is not uncommon. They are caused by either a disorder that is unique to pregnancy or an acute or chronic liver disease that already exists or coincidentally develops as a comorbidity of pregnancy. Liver diseases unique to pregnancy include hyperemesis gravidarum; hypertensive disorders of pregnancy, such as pre-eclampsia/eclampsia; hemolysis, elevated liver enzymes, and low platelet count syndrome; intrahepatic cholestasis of pregnancy; and acute fatty liver of pregnancy. Chronic liver diseases that affect pregnancy, or are affected by pregnancy, mainly include autoimmune liver diseases and non-alcoholic fatty liver disease. Prompt diagnosis and management of liver diseases in pregnancy, while very challenging, is extremely important, as they might cause adverse maternal and fetal outcomes. Therefore, a multidisciplinary, collaborative approach involving both hepatologists and obstetricians is required. In this review article, the up-to-date epidemiology, etiology, clinical features, and outcomes of liver diseases in pregnancy are discussed, to promote a deeper understanding among physicians, and subsequently improved outcomes. - Effect of MDM2 inhibitors in preclinical models of advanced clear cell carcinomas originating from ovaries and kidneys.
Yoshiko Kawata; Kazunori Nagasaka; Katsutoshi Oda; Chinami Makii; Makoto Takeuchi; Shinya Oki; Harunori Honjo; Machiko Kojima; Yuko Miyagawa; Ayumi Taguchi; Michihiro Tanikawa; Kenbun Sone; Haruko Hiraike; Yoko Matsumoto; Osamu Wada-Hiraike; Takuya Ayabe; Yutaka Osuga; Tomoyuki Fujii
Cancer science, 25 Jul. 2020, [Reviewed]
Advanced clear cell carcinomas originating from both ovaries and kidneys with cancerous peritonitis have poor prognoses. Murine double-minute 2 is a potential therapeutic target for clear cell ovarian carcinomas with wild-type TP53. Herein, we characterized the anti-angiogenic and antitumor effects of the Murine double-minute 2 inhibitors, DS-3032b and DS-5272, in six clear cell ovarian carcinoma cell lines and two clear cell renal carcinoma cell lines, as well as in clear cell ovarian carcinomas subcutaneous xenograft and ID8 (murine ovarian cancer cells with wild-type TP53) cancer peritonitis mouse models. In clear cell ovarian carcinomas subcutaneous xenograft mouse models, DS-3032b significantly reduced wild-type TP53 clear cell ovarian carcinomas- and clear cell renal carcinoma-derived tumor volumes. In ID8 mouse models, DS-5272 significantly inhibited ascites production, reduced body weight, and significantly improved overall survival. Additionally, DS-5272 reduced the tumor burden of peritoneal dissemination and decreased CD31+ cells in a dose-dependent manner. Furthermore, DS-5272 significantly decreased vascular endothelial growth factor concentrations in both sera and ascites. Meanwhile, combined therapy with MDM2 inhibitors and everolimus showed synergistic, and dose-reduction potential, for clear cell carcinoma treatment. Our findings suggest that Murine double-minute 2 inhibitors represent promising molecular targeted therapy for clear cell carcinomas, thereby warranting further studies to evaluate the efficacy and safety of dual Murine double-minute 2/mammalian target of rapamycin inhibitors in clear cell carcinoma patients. - 画像上良性で子宮内膜細胞診も陰性であったが経腟的子宮鏡下腫瘍摘出術(TCR)後に悪性病変が指摘された2例
Jul. 2020 - 胎児腹水を呈した胎便性腹膜炎の2例
Jun. 2020 - Rikkunshito attenuates induction of epithelial-mesenchymal switch via activation of Sirtuin1 in ovarian cancer cells.
Ranka Kanda; Yuko Miyagawa; Osamu Wada-Hiraike; Haruko Hiraike; Shiho Fukui; Kazunori Nagasaka; Eiji Ryo; Tomoyuki Fujii; Yutaka Osuga; Takuya Ayabe
Endocrine journal, 28 Apr. 2020, [Reviewed]
Rikkunshito, a traditional Japanese herbal medicine, improves appetite via activation of gastrointestinal hormone ghrelin pathway. The function of ghrelin is mediated by growth hormone secretagogue receptor (GHSR1a), and ghrelin has been known to possess diverse physiological functions including growth suppression of some cancer cells. Considering that increased ghrelin signaling by Rikkunshito could enhance sirtuin1 (SIRT1) activity in nervous system, we aimed to investigate the effect of Rikkunshito in ovarian cancer cells. Ovarian cancer cell lines were treated with Rikkunshito, and cellular viability, gene expressions and epithelial-mesenchymal transition (EMT) status were investigated. To investigate the involvement of SIRT1 by Rikkunshito in SKOV3 cancer cells, endogenous expression of SIRT1 was depleted using small interfering RNA (siRNA). Treatment with Rikkunshito elevated ghrelin, GHSR1a and SIRT1, while cellular viability was decreased. The treatment of Rikkunshito also inhibited cellular migration and invasion status in a dose-dependent manner, and these effects were translated to the enhanced EMT status, although the role of SIRT1 was not determined. Our study revealed a novel function of Rikkunshito in enhancing EMT status of ovarian cancer cells. Therefore, we would like to propose that Rikkunshito may be used as a novel adjunctive therapy in chemotherapy of ovarian cancer because platinum-based chemotherapy frequently used for the treatment of ovarian cancer inevitably impairs appetite. - 早産に至った例の胎動数 FMAM recorderでの計測
Mar. 2020 - 胎動と出生時体重とは関連するのか? FMAMレコーダーを用いて
Mar. 2020 - 進行卵巣癌・腹膜癌に対する審査腹腔鏡の有用性に関する検討
Mar. 2020 - 産科危機的出血に対する開腹術中に心室細動を生じdamage control surgery(DCS)にて救命した1例
Mar. 2020 - Intraoperative monitoring of placental blood flow after cesarean birth to diagnose placenta accreta spectrum disorder: A preliminary study
Eiji Ryo; Shigenari Namai; Michiharu Seto; Masahiro Shiba; Koichiro Kido; Takuya Ayabe
International Journal of Gynecology & Obstetrics, Feb. 2020 - Ovarian hyperstimulation closely associated with resumption of follicular growth after chemotherapy during tamoxifen treatment in premenopausal women with breast cancer: A multicenter retrospective cohort study
Rena Yamazaki; Masafumi Inokuchi; Satoko Ishikawa; Takuya Ayabe; Hiromitsu Jinno; Takashi Iizuka; Masanori Ono; Subaru Myojo; Soko Uchida; Toshiya Matsuzaki; Akira Tangoku; Masato Kita; Tomoharu Sugie; Hiroshi Fujiwara
BMC Cancer, 29 Jan. 2020, [Reviewed] - Ovarian hyperstimulation closely associated with resumption of follicular growth after chemotherapy during tamoxifen treatment in premenopausal women with breast cancer: a multicenter retrospective cohort study.
Rena Yamazaki; Masafumi Inokuchi; Satoko Ishikawa; Takuya Ayabe; Hiromitsu Jinno; Takashi Iizuka; Masanori Ono; Subaru Myojo; Soko Uchida; Toshiya Matsuzaki; Akira Tangoku; Masato Kita; Tomoharu Sugie; Hiroshi Fujiwara
BMC cancer, 29 Jan. 2020, [Reviewed]
BACKGROUND: We previously reported that tamoxifen (TAM)-induced ovarian hyperstimulation (OHS) is associated with high serum concentrations of estradiol in premenopausal women with breast cancer. To investigate risk factors for TAM-induced OHS, we performed a retrospective multicenter study. METHODS: Premenopausal patients who received surgical therapy for endocrine-dependent breast cancer (n = 235) were recruited in this study and classified into 4 groups: group A, treated with TAM alone; group B, TAM treatment after 2-year-combined therapy with a gonadotropin-releasing hormone (Gn-RH) agonist; group C, TAM treatment after chemotherapy; group D, 5-year-combined therapy with TAM and a Gn-RH agonist. A serum estradiol value of more than 300 pg/mL or mean follicular diameter of more than 30 mm was defined as OHS. RESULTS: The incidence of OHS in group A (n = 13/26, 50.0%) was significantly higher than those in group B (n = 17/63, 27.0%), group C (n = 20/110, 18.2%), and group D (n = 0/36, 0%). The incidence of OHS was significantly correlated with aging, and the median serum concentration of estradiol in the presence of OHS was 823.0 pg/mL. The incidence of OHS (less than 47 years old) was 62.5% in group A, 48.6% in group B, and 28.2% in group C, respectively. Notably, the incidence rate of OHS following amenorrhea in group C (n = 13/20, 65.0%) was significantly higher than that in group B (n = 1/17, 5.9%). CONCLUSIONS: These findings indicate that the onset of OHS following amenorrhea was common in the post-chemotherapeutic group, while its ratio was low in the group after Gn-RH analog treatment, suggesting that combined treatment-based management involving TAM therapy is necessary for premenopausal patients with breast cancer. - Primary treatment and prognosis in 15 cases with stage IVB cervical cancer
Ranka Kanda; Kazunori Nagasaka; Takeru Sugihara; Haruko Hiraike; Eiji Ryo; Takuya Ayabe
Teikyo Medical Journal, 2020 - 当院における子宮頸癌IVB期15例の初回治療内容と予後について
Jan. 2020 - Anti-Tumor Effect of Inhibition of DNA Damage Response Proteins, ATM and ATR, in Endometrial Cancer Cells.
Makoto Takeuchi; Michihiro Tanikawa; Kazunori Nagasaka; Katsutoshi Oda; Yoshiko Kawata; Shinya Oki; Chuwa Agapiti; Kenbun Sone; Yuko Miyagawa; Haruko Hiraike; Osamu Wada-Hiraike; Hiroyuki Kuramoto; Takuya Ayabe; Yutaka Osuga; Tomoyuki Fujii
Cancers, 01 Dec. 2019, [Reviewed]
: While the incidence of endometrial cancer continues to rise, the therapeutic options remain limited for advanced or recurrent cases, and most cases are resistant to therapy. The anti-tumor effect of many chemotherapeutic drugs and radiotherapy depends on the induction of DNA damage in cancer cells; thus, activation of DNA damage response (DDR) pathways is considered an important factor affecting resistance to therapy. When some DDR pathways are inactivated, inhibition of other DDR pathways can induce cancer-specific synthetic lethality. Therefore, DDR pathways are considered as promising candidates for molecular-targeted therapy for cancer. The crosstalking ataxia telangiectasia mutated and Rad3 related and checkpoint kinase 1 (ATR-Chk1) and ataxia telangiectasia mutated and Rad3 related and checkpoint kinase 2 (ATM-Chk2) pathways are the main pathways of DNA damage response. In this study, we investigated the anti-tumor effect of inhibitors of these pathways in vitro by assessing the effect of the combination of ATM or ATR inhibitors and conventional DNA-damaging therapy (doxorubicin (DXR), cisplatin (CDDP), and irradiation) on endometrial cancer cells. Both the inhibitors enhanced the sensitivity of cells to DXR, CDDP, and irradiation. Moreover, the combination of ATR and Chk1 inhibitors induced DNA damage in endometrial cancer cells and inhibited cell proliferation synergistically. Therefore, these molecular therapies targeting DNA damage response pathways are promising new treatment strategies for endometrial cancer. - The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-β/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer.
Fukui S; Nagasaka K; Miyagawa Y; Kikuchi-Koike R; Kawata Y; Kanda R; Ichinose T; Sugihara T; Hiraike H; Wada-Hiraike O; Sasajima Y; Ayabe T
Oncotarget, Oct. 2019, [Reviewed] - 当科病棟における院内感染予防目的での手指衛生実施状況について
Sep. 2019 - 当科病棟における院内感染予防目的での手指衛生実施状況について
Sep. 2019 - 子宮動脈塞栓術後、妊娠・出産に至った3例
May 2019 - 予防的Shirodkar頸管縫縮術施行後の頸管長変化
Apr. 2019 - FMAMレコーダーを使用して胎動を複数回計測した胎児胸水の2例
Apr. 2019 - 辺縁静脈洞が子宮頸管内に下垂した低置胎盤の1例
Apr. 2019 - Descended marginal sinus of the placenta.
Eiji Ryo; Shigenari Namai; Ippei Nakagawa; Ranka Kanda; Keita Yatsuki; Takuya Ayabe
Clinical case reports, Apr. 2019
This is the first reported case of descent of the placental marginal sinus through the cervix to the external os. We think marginal sinus rupture does exist. The definition of placental edge should be the parenchyma in diagnosis of low-lying placentation. Clinically, however, the low-lying marginal sinus should be treated similar to low-lying placentation. - 持続血糖測定とFMAM recorderによる胎動測定を同時連続的に行ったGDMの1例
Feb. 2019 - 胎動数と出生時体重との関係について FMAMレコーダーを使用して
Feb. 2019 - 病理解剖で確定診断した先天性上気道閉塞症候群の一例
Feb. 2019 - Elevated Expression of Vascular Adhesion Molecule-1, Plasminogen Activator Inhibitor-1, Cyclooxygenase-2, and Thrombomodulin in Human Umbilical Vein Endothelial Cells from Hospitalized Gestational Diabetes Mellitus Patients.
Takata Y; Nomura K; Ishibashi K; Kido K; Sasamori Y; Hiraike H; Ayabe T; Atsumi GI
Biol Pharm Bull, 2019, [Reviewed] - 【婦人科がん最近の話題】婦人科がん診療に関する最近の話題 ゲノム医療の時代を迎えて
Aug. 2018, [Reviewed] - Expression of the glucagon-like peptide-1 receptor and its role in regulating autophagy in endometrial cancer.
Ranka Kanda; Haruko Hiraike; Osamu Wada-Hiraike; Takayuki Ichinose; Kazunori Nagasaka; Yuko Sasajima; Eiji Ryo; Tomoyuki Fujii; Yutaka Osuga; Takuya Ayabe
BMC cancer, 15 Jun. 2018, [Reviewed]
BACKGROUND: A previous report showed that a glucagon-like peptide-1 receptor (GLP-1R) agonist (exenatide) induced apoptosis in endometrial cancer cells. However, the pathophysiological role of GLP-1R in endometrial cancer has not been fully elucidated. Here, we investigated the effects of the GLP-1R agonist liraglutide in endometrial cancer cells and examined the association between GLP-1R expression and clinicopathological characteristics in endometrial cancer patients. METHODS: Human Ishikawa endometrial cancer cells were treated with different concentrations of liraglutide. To assess the effects of liraglutide, cell viability, colony formation, flow cytometry, Western blotting, and immunofluorescence assays were performed. Autophagy induction was examined by analyzing LC3 and p62 expression and autophagosome accumulation. Moreover, using a tissue microarray, we analyzed GLP-1R expression in 154 endometrial cancer tissue samples by immunohistochemistry. RESULTS: In accordance with the previous report, liraglutide inhibited Ishikawa cell growth in a dose-dependent manner. Liraglutide significantly induced autophagy, and phosphorylated AMPK expression was elevated. Immunohistochemical analysis revealed that GLP-1R expression was associated with positive estrogen receptor and progesterone receptor status, and higher GLP-1R expression was significantly correlated with better progression-free survival. CONCLUSIONS: The use of liraglutide to target autophagy in endometrial cancer cells may be a novel potential treatment for endometrial cancer. Furthermore, higher GLP-1R expression may be associated with better prognosis in endometrial cancer patients. - 臍帯長と胎動数の関連についての研究
Jun. 2018 - 胎動計を用いて長時間の胎動を評価し得たタナトフォリック骨異形成症の一例
Jun. 2018 - 結腸癌術後経過観察中に卵巣奇形腫が小腸に穿通し,同部位に結腸癌の血行性転移を認めた1例
Feb. 2018 - 性交渉未経験女性に発症した子宮頸部腺癌の1例
Jan. 2018 - Changes in uterine flexion caused by cesarean section: correlation between post-flexion and deficient cesarean section scars
Eiji Ryo; Rina Sakurai; Hideo Kamata; Michiharu Seto; Masayoshi Morita; Takuya Ayabe
JOURNAL OF MEDICAL ULTRASONICS, Apr. 2016, [Reviewed] - Loss of the cell polarity determinant human Discs-large is a novel molecular marker of nodal involvement and poor prognosis in endometrial cancer
Takeru Sugihara; Shunsuke Nakagawa; Yuko Sasajima; Takayuki Ichinose; Haruko Hiraike; Fukuo Kondo; Hiroshi Uozaki; Toshio Fukusato; Takuya Ayabe
BRITISH JOURNAL OF CANCER, Apr. 2016, [Reviewed] - Transperineal ultrasound
KIDO Kouichiro; BARBERA Antonino; RYO Eiji; AYABE Takuya
Choonpa Igaku, 2016
Transperineal ultrasound (TPU) started to be used in the 1970-80s for assisting biopsies of the prostate. Only in the mid to late 1990s did it become a tool used by both urogynecologists and obstetricians. Different from invasive urodynamic tests, and digital vaginal or digital rectal examination, this approach is noninvasive and well tolerated by patients. While MRI or CT examination requires expensive equipment and highly trained personnel, TPU is easy to perform and can be done in real time to answer the clinical question being investigated. Furthermore, cine loop clips are easily acquired and stored for later evaluation and for educational purposes. In urogynecology, TPU can be used to visualize the urethra and its hypermobility, being useful for diagnosis of stress urinary incontinence. During labor, TPU allows an objective assessment of fetal head descent in the birth canal. Many other measurements have been proposed by different scientists: the angle of progression, the head direction, the progression distance, and the head-perineum distance. The angle of progression is the most widely used parameter. TPU is also used to assess fetal head rotation, with both 2D and 3D images. The latter helps with the visualization of fetal sagittal suture in real time. It is clear that with all these potentialities, TPU can become the most objective way to help in making a key decision at time of delivery: perform an operative vaginal or potentially difficult cesarean delivery. In postpartum, TPU can be used to visualize the rectal sphincter, and it is being used to identify patients at high risk for fecal incontinence. Nowadays, TPU is becoming the most advanced and objective tool used in many labor and delivery units around the world during the first and second stage of labor to assess fetal position and fetal station, and in puerperium to visualize the rectal sphincter. - Case of minimal deviation adenocarcinoma: possible clinical link to lobular endocervical glandular hyperplasia as its origin.
Sugihara T; Nakagawa S; Sasajima Y; Matsumoto Y; Takeshita S; Ayabe T
The journal of obstetrics and gynaecology research, Mar. 2015, [Reviewed] - 無脂肪・無残渣流動食の非消化管手術前投与の検討(第2報)
Jun. 2014, [Reviewed] - 当科における婦人科悪性腫瘍前駆病変に対する低侵襲手術の試み
Jun. 2014, [Reviewed] - 卵巣明細胞腺癌の原発巣とリンパ節転移巣とにおけるβhCGの発現の解析
Jun. 2014, [Reviewed] - 卵巣癌で非転移リンパ節郭清を省略するための傍大動脈リンパ節に対する術中超音波検査の有用性
Jun. 2014, [Reviewed] - 術中超音波検査により、進行子宮体がんの傍大動脈リンパ節郭清は47%省略可能となる
Jun. 2014, [Reviewed] - 子宮内膜癌における子宮腺筋症の臨床および病理学的意義の検討
Jun. 2014, [Reviewed] - 再発子宮頸部小細胞癌に対してアムルビシン(AMR)を投与した1例
May 2014 - 異なる転帰をたどった周産期心筋症(Peripartum cardiomyopathy:PPCM)の2例
May 2014, [Reviewed] - 新生児劇症型心筋炎の一例
May 2014, [Reviewed] - 卵巣子宮内膜症性嚢胞の脱落膜変化と悪性化とは鑑別可能か?
Apr. 2014, [Reviewed] - 卵巣癌において傍大動脈リンパ節転移を評価するための術中超音波検査の有用性
Apr. 2014, [Reviewed] - 転移性子宮癌の4例
Apr. 2014, [Reviewed] - 分娩前後での子宮のflexionの変化 分娩様式および帝王切開創楔状欠損との関連
Apr. 2014, [Reviewed] - 【思春期女性のヘルスケア】 早発思春期
Mar. 2014, [Reviewed] - 卵管鏡下卵管形成術の成績からみた生殖医療諸因子の検討
Mar. 2014, [Reviewed] - 妊婦の子宮内環境の把握を目指した取り組み
Mar. 2014, [Reviewed] - 異所性妊娠
Feb. 2014, [Reviewed] - 年齢層別にみた卵管性不妊症例における卵管鏡下卵管形成術の成績
Feb. 2014, [Reviewed] - 陣痛促進中にきたしたDICの原因が子宮型羊水塞栓症と推測された1例
Feb. 2014, [Reviewed] - 広汎子宮頸部摘出術後の症例に対し妊娠中に経腟的子宮頸管縫縮術を施行し得た一例
Feb. 2014, [Reviewed] - 潜在性甲状腺機能低下症の流早産への影響
Feb. 2014, [Reviewed] - 子宮内膜癌における予後因子の解析 肥満は子宮内膜癌の予後良好因子である
Feb. 2014, [Reviewed] - エストロゲン転写共役因子SRC-3を分解の標的とするユビキチンライゲースCHIP(carboxyl terminus of HSC 70-interracting protein)の子宮内膜癌における発現は分化度の進行に伴い増強する
Feb. 2014, [Reviewed] - 両側卵管留水症合併不妊症例における卵管鏡下卵管形成術の検討
Oct. 2013, [Reviewed] - 両側卵管閉塞症例における卵管鏡下卵管形成術(FT)の検討 閉塞卵管開通(両側・片側)での比較
Aug. 2013 - 子宮腺筋症から発生したと考えられた子宮体部明細胞腺癌の1例
Aug. 2013, [Reviewed] - 帝王切開術中に多量出血をきたし子宮摘出を余儀なくされた子宮型羊水塞栓症が示唆された1例
Aug. 2013, [Reviewed] - 子宮頸部腺癌術後に癌性腹膜炎で発見された乳癌(浸潤性小葉癌)の1例
Jul. 2013 - 胎動数を自動的に計測しその減少に対して警報音を発するFMAM recorderの開発
Jun. 2013 - 両側原発性乳糜胸症に対して、胎児胸腔羊水腔シャント術を施行した一例
Jun. 2013 - 5,000ml以上の出血を来した帝王切開既往の前置癒着胎盤の3症例
Jun. 2013 - 母体梅毒感染の3症例の検討
Jun. 2013 - 3通りの方法で妊娠中に管理されそれぞれ違う経過をたどった頸管無力症の1例
Jun. 2013 - 子宮頸癌の腫瘍径と臨床像との関連に関する検討
Jun. 2013 - 子宮頸癌に対するプラチナ併用CPT-11療法におけるUGT1A1遺伝子多型解析の意義
Jun. 2013 - 進行卵巣癌手術における婦人科医と消化器外科医の接点 当科における婦人科癌合同手術の検討
May 2013 - 子宮頸癌のCCRT(concurrent chemoradiotherapy)後に発症した子宮癌肉腫の1例
May 2013, [Reviewed] - 【産婦人科当直医マニュアル-慌てないための虎の巻】 婦人科編 「救急/時間外」の婦人科疾患 卵巣過剰刺激症候群
Apr. 2013 - 帝王切開瘢痕部妊娠の4例
Apr. 2013 - 胎児期に嚢胞性腫瘤として認められた副腎出血の1例
Apr. 2013 - 【ホルモン療法実践マニュアル】 生殖内分泌分野 早発思春期
Mar. 2013 - 経会陰超音波(Transperineal Ultrasound, TPU)で評価を行った早産の一例
Mar. 2013 - An evaluation of uterine muscle contractions in women with threatened premature and terminal labor using ultrasound elastography
Yasuhiro Matsumoto; Eiji Ryo; Hideo Kamata; Takuya Ayabe
Choonpa Igaku, 01 Feb. 2013 - 子宮内・頸管内同時妊娠で生児を得た一例
Feb. 2013 - 細胞極性決定因子であるHugl-1遺伝子のframe shift変異による発現異常の子宮内膜癌発生における意義
Feb. 2013 - 子宮筋腫合併妊娠における経腟分娩時の出血に関与する因子の検討
Feb. 2013 - 子宮頸部円錐切除術と多部位生検併用レーザー蒸散術との比較検討
Feb. 2013 - 子宮頸部初期病変手術後妊娠の転帰について
Feb. 2013 - 当科における片側卵管閉塞症例における卵管鏡下卵管形成術の検討
Feb. 2013 - 【危機的出血をきたす周産期DIC治療の新戦略】 自己血輸血法
Dec. 2012 - 【妊孕能を考える】 治療の実際 比較的高齢女性の不妊治療
Nov. 2012 - 妊娠後期にウイルス関連の血球貪食症候群(Hemophagocytic syndrome;HPS)を発症した1例
Oct. 2012 - 当院で取り扱った東京都母体救命搬送(スーパー母体搬送)システム該当症例の検討
Aug. 2012 - 妊婦一過性大腿骨頸部骨粗鬆症(TOHP:Transient Osteroporosis of the Hip in Pregnency)の1例
Aug. 2012 - 当院における妊婦健診未受診の検討
May 2012 - 子宮卵巣摘出19年後、腟断端に卵巣組織由来の明細胞腺癌が発生した1例
Jun. 2009 - Uterine endometrial ablation by Cool-tip® radiofrequency ablation system
Ryo Eiji; Shiba Masahiro; Arimura Kenichiro; Kamata Hideo; Takeshita Shigeki; Ayabe Takuya
Journal of Microwave Surgery, 2008
Purpose: The purpose was to evaluate the effectiveness of Cool-tip® radiofrequency ablation system for uterine endometrial ablation.
Methods: Eleven women with a complaint of hypermenorrhea underwent endometrial ablation with Cool-tip® RFA system.
Results: The ablation was smoothly performed in all women, and they could leave our hospital the following day. Ten women could avoid the hysterectomy. However, intestine perforations caused by burn injury occurred in one woman two days after the surgery.
Conclusions: Endometrial ablation using Cool-tip® RFA system is not safe in the present situations. - Uterine metastasis from hepatocellular carcinoma: a case report
E. Ryo; T. Sato; S. Takeshita; T. Ayabe; F. Tanaka
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Sep. 2006, [Reviewed] - A study of adjuvant therapy for glassy cell carcinoma (GCC) of the uterine cervix
Tsuyoshi Fujino; Hitoshi Koizumi; Shigeki Takeshita; Kennichiro Arimura; Tomoyuki Sato; Takayuki Murase; Eiji Ryo; Youji Fuse; Fumihiko Tanaka; Takuya Ayabe; Shouichi Okinaga
Teikyo Medical Journal, Sep. 2005 - Blood coagulation, fibrinolysis and platelet function in endometriosis
Yoji Fuse; Tsuyoshi Fujino; Takuya Ayabe; Shoichi Okinaga
Teikyo Medical Journal, May 2005 - 子宮頸部glassy cell carcinomaに対する術後療法の検討
2005, [Reviewed] - クラミジアトラコマチス感染における血清学的病期分類の試みとその臨床的意義について
Dec. 2004 - DELAYED EXPRESSION OF HEXOKINASE AND GLUCOSE-TRANSPORTER CAUSES DECREASED GLUCOSE INCORPORATION IN MOUSE EMBRYOS DEVELOPED IN-VITRO
O TSUTSUMI; Y MORITA; HOSOYA, I; T AYABE; T YANO; Y TAKETANI
PERSPECTIVES ON ASSISTED REPRODUCTION, 1994, [Reviewed] - Influence of peritoneal fluid with endometriosis on the development of mouse embryos
T. M. Kuo; Y. Taketani; T. Ayabe; H. Gomibuchi; T. Yano; O. Tsutsumi; M. Mizuno
Acta Obstetrica et Gynaecologica Japonica, 1990, [Reviewed] - PRODUCTION OF PROGESTERONE BY PREIMPLANTATION EMBRYO - A POSSIBLE FACTOR CONTROLLING EARLY EMBRYO DEVELOPMENT
O TSUTSUMI; T AYABE; T YANO; K SATOH; M MIZUNO
HUMAN REPRODUCTION /, 1988, [Reviewed] - Detection of a single HPV RNA molecule in stratified mucin-producing intraepithelial lesion (SMILE) with concurrent cervical intraepithelial lesion : Acase report
Shiho Fukui; Kazunori Nagasaka; Naoko Iimura; Ranka Kanda; Takayuki Ichinose; Takeru Sugihara; Haruko Hiraike; Shunsuke Nakagawa; Yuko Sasajima; Takuya Ayabe
Virology Journal, [Reviewed]
MISC
- Intraoperative ultrasonography of paraaortic lymph nodes during laparoscopic total hysterectomy for uterine cancer
橋本啓; 梁栄治; 八木慶太; 一瀬隆行; 櫻井理奈; 杉原武; 生井重成; 長阪一憲; 綾部琢哉
超音波医学 Supplement, 2021 - 胎児腹水を呈した胎便性腹膜炎の2例
2020 - 採卵後の子宮内膜症性嚢胞に膿瘍ができた1例
Jan. 2020 - オラパリブ維持療法が奏効した3レジメンの化学療法歴がある高齢者の再発卵巣癌の1例
Oct. 2019 - OHVIRA症候群が疑われた2例
Sep. 2019 - 当院における子宮頸癌IVB期15例の治療内容と予後について
Jun. 2019 - 当院における横隔膜播種を認めた卵巣癌、腹膜癌23例の後方視的検討
Jun. 2019 - 卵巣明細胞癌におけるUCHL5の発現と予後についての検討
Jun. 2019 - プラチナ製剤抵抗性再発卵巣癌に対するトポテカン塩酸塩・ベバシズマブ併用化学療法の有効性および有害事象についての検討
Feb. 2019 - 子宮体癌根治術において術中超音波検査により傍大動脈リンパ節郭清を省略した患者の予後
Feb. 2019 - 当科で施行した子宮頸部病変に対する多部位周状生検併用レーザー蒸散術の検討
Feb. 2019 - 出生前に血管輪・右大動脈弓・胆嚢拡大を認め生後ルビンシュタイン・テイビ症候群(Rubinstein-Taybi syndrome;RTS)と判明した1例
Feb. 2019 - 当科で施行した子宮頸部病変に対する多部位周状生検併用レーザー蒸散術の検討
橋本 啓; 長阪 一憲; 杉原 武; 神田 蘭香; 福井 志保; 一瀬 隆行; 平池 春子; 松本 泰弘; 竹下 茂樹; 笹島 ゆう子; 梁 栄治; 綾部 琢哉
日本産科婦人科学会雑誌, Feb. 2019
(公社)日本産科婦人科学会 - OHVIRA症候群が疑われた2例
2019 - 術後に再発した粘液性境界悪性腫瘍(mBOT)の2例
Jan. 2019 - 双胎・切迫早産で母体搬送され、緊急帝王切開後に産褥心筋症を生じた1例
Oct. 2018 - 月経後の周期的な下腹痛を生じる嚢胞性子宮腺筋症に対し腹腔鏡下腫瘍摘出術を施行した1例
Oct. 2018 - 子宮体癌術後の難治性リンパ嚢胞に対しリンパ管造影検査にて漏出部位の同定を行った1例
橋本 啓; 松本 泰弘; 生井 重成; 福井 志保; 一瀬 隆行; 平池 春子; 長阪 一憲; 梁 栄治; 綾部 琢哉
東京産科婦人科学会会誌, Jul. 2018
(一社)東京産科婦人科学会 - G-CSF産生の外陰部有棘細胞癌の1例
原藤 緑; 田中 隆光; 鎌田 昌洋; 大西 誉光; 多田 弥生; 野澤 慶次郎; 武藤 智; 綾部 琢哉; 渡辺 晋一
Skin Cancer, Jun. 2018
(一社)日本皮膚悪性腫瘍学会 - 子宮筋腫表面の血管叢が妊娠中に破綻しショックをきたした1例
木戸 浩一郎; 橋本 啓; 一瀬 隆行; 櫻井 理奈; 岸本 倫太郎; 平池 春子; 長阪 一憲; 松本 泰弘; 司馬 正浩; 笹森 幸文; 梁 栄治; 綾部 琢哉
関東連合産科婦人科学会誌, May 2018
(一社)関東連合産科婦人科学会 - 当科病棟における院内感染予防目的での手指衛生実施状況について
司馬 正浩; 八木 慶太; 西澤 美紀; 橋本 啓; 長屋 陽平; 中川 一平; 神田 蘭香; 瀬戸 理玄; 福井 志保; 森田 政義; 一瀬 隆行; 櫻井 理奈; 生井 重成; 岸本 倫太郎; 平池 春子; 長阪 一憲; 松本 泰弘; 末永 昭彦; 笹森 幸文; 木戸 浩一郎; 梁 栄治; 綾部 琢哉
日本産婦人科感染症学会学術講演会プログラム・抄録集, May 2018
(一社)日本産婦人科感染症学会 - 帝京大学における遺伝性乳癌卵巣癌症候群(HBOC)に対する遺伝カウンセリング外来の実施と体制整備について
長阪一憲; 長阪一憲; 青木美保; 木戸浩一郎; 瀬戸理玄; 杉原武; 平池春子; 渡邊清高; 梁栄治; 関順彦; 関順彦; 神野浩光; 綾部琢哉
日本人類遺伝学会大会プログラム・抄録集, 2018 - 性交渉未経験女性に発症した子宮頸部腺癌の1例
西澤 美紀; 一瀬 隆行; 岸本 倫太郎; 橋本 啓; 長屋 陽平; 中川 一平; 瀬戸 理玄; 平池 春子; 松本 泰弘; 梁 栄治; 綾部 琢哉; 笹島 ゆう子
東京産科婦人科学会会誌, Jan. 2018
(一社)東京産科婦人科学会 - G-CSF産生の外陰部有棘細胞癌の1例
原藤 緑; 田中 隆光; 大西 誉光; 多田 弥生; 綾部 琢哉; 野澤 慶次郎; 武藤 智; 渡辺 晋一
日本皮膚悪性腫瘍学会学術大会プログラム・抄録集, May 2017
(一社)日本皮膚悪性腫瘍学会 - Immunohistological overexpression of Glypican-3 is associated with early clinical stage and better progression free survival in ovarian clear cell carcinoma
R. Kanda; S. Nakagawa; T. Ichinose; T. Sugiha; S. F. Shiho Fukui; M. Osawa; Y. Sasajima; H. Uozaki; T. Ayabe
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Oct. 2016 - 月経痛の診断と治療 (今月の臨床 若年女性の外来診療に役立つ基礎知識)
Jun. 2016 - INCREASING TRENDS OF WELL-DIFFERENTIATED ENDOMETRIOID ADENOCARCINOMA IN JAPANESE PATIENTS WITH ENDOMETRIAL CANCER
S. Fukui; S. Nakagawa; T. Ichinose; T. Sugihara; S. Takeshita; T. Ayabe
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Oct. 2015 - ANALYSIS OF CLINICOPATHOLOGICAL AND MOLECULAR SIGNIFICANCE OF OBESITY IN JAPANESE PATIENTS WITH ENDOMETRIAL CANCER
T. Sugihara; S. Nakagawa; S. Fukui; T. Ichinose; T. Tsuruga; S. Takeshita; Y. Sasajima; S. Liang; T. Ayabe
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Oct. 2015 - BETA-SUBUNIT OF HUMAN CHORIONIC GONADOTROPIN EXPRESSION IS A NOVEL BIOMARKER OF OVARIAN CLEAR CELL CARCINOMA FOR POOR PROGNOSIS
T. Ichinose; S. Nakagawa; T. Sugihara; S. Fukui; S. Takeshita; Y. Sasajima; T. Ayabe
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Oct. 2015 - ISP-1-3 Inactivation of Hippo pathway due to loss of cell polarity determinants expression has a critical role in development of undifferentiated endometrial cancer(Group 1 Oncology 1,IS Poster,International Session) :
Sugihara Takeru; Nakagawa Shunsuke; Sasajima Yuko; Ichinose Takayuki; Takeshita Shigeki; Ryo Eiji; Liang Shan-Guang; Ayabe Takuya
2015 - OBESITY AS A PROGNOSTIC INDICATOR IN ENDOMETRIAL CANCER
T. Sugihara; S. Nakagawa; Y. Sasajima; T. Ichinose; S. Takeshita; T. Ayabe
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Nov. 2014 - ISP-6-4 Loss of cell polarity determinant human Discs-large is a novel molecular marker of nodal involvement, distant metastasis and poor prognosis(Group 6 Oncology 6,IS Poster,International Session) :
Sugihara Takeru; Nakagawa Shunsuke; Kanda Ranka; Ichinose Takayuki; Takeshita Shigeki; Ryo Eiji; Ayabe Takuya
2014 - 産婦人科教室 私たちの教室紹介(series26)帝京大学医学部産婦人科学教室
Feb. 2012 - The reliability of cytology for the uterine cervix in pregnancy
TAKESHITA Shigeki; KITA Tsunekazu; SUGIURA Atsushi; SUGIHARA Takeru; SUGISAKI Souichi; MATSUMOTO Yasuhiro; RYO Eiji; AYABE Takuya
25 Jun. 2011 - Minimal deviation adenocarcinomaの1例
Jun. 2011 - Hyperdysmenorrhea
May 2011 - 一絨毛膜一羊膜双胎の2例
May 2011 - UGT1A1遺伝子多型と既往レジメン数とに基づいた塩酸イリノテカン(CPT-11)投与量の検討
Sep. 2010 - UGT1A1の遺伝子多型と既往レジメン数とに基づいた塩酸イリノテカン(CPT-11投与量)の検討について
Jun. 2010 - 1型糖尿病合併妊婦に脊髄梗塞を発症した一例
May 2010 - GnRHによる生殖機能調節 (特集 生殖機能調節の新しい視点)
Mar. 2010 - 単純子宮全摘出術 (特集 産科大量出血に備える) -- (産科大量出血時の対処)
Sep. 2009 - Reproductive performance in women with uterine anomalies
Japanese journal of clinical medicine, Aug. 2009 - 子宮外妊娠診断法の工夫 (特集 初期妊娠異常の診断と管理)
Mar. 2009 - A case of aggressive angiomyxoma of the vulva
YOKOYAMA Sachiyo; SUGIURA Satoshi; ARIMURA Kennichiro; TAKESHITA Shigeki; RYO Eiji; AYABE Takuya
25 Jun. 2007 - Blood Coagulation and Deep Venous Thrombosis in Twin Pregnancy
ARIMURA Ken'Ichiro; SHIMIZU Yasuki; TAGUCHI Akinori; MACHIDA Ryota; MATSUMOTO Yasuhiro; KIDO Koichiro; RYO Eiji; AYABE Takuya; MASUGI Hideo
15 Apr. 2007 - 子宮外妊娠 (特集 今,改めて"母子救急"を考える)
Feb. 2007 - A clinical study of treatment for the advanced cervical cancer with bulky cervical tumor
TAKESHITA Shigeki; YOKOYAMA Sachiyo; SUGIURA Satoshi; ARIMURA Kenichiro; SATOH Tomoyuki; FUJINO Tsuyoshi; RYO Eiji; AYABE Takuya
25 Apr. 2006 - ダイオキシンによるヒト正所性子宮内膜interleukin‐1 receptor type II発現の減少
五十嵐敏雄; 瀧沢聡子; 川村久恵; 中川圭介; 山藤晶子; 綾部琢哉; 上里忠和; 大岡史子; 梁善光; 堤治; 武谷雄二; OSTEEN Kevin G
エンドメトリオーシス研究会会誌, 25 Jul. 2005 - 産婦人科領域における最近の治療法
30 Dec. 2004 - Management of Pregnant Women with Toxoplasma IgM Antibody
KAWANA Takashi; MURATA Teruo; KOJIMA Toshiyuki; AYABE Takuya
01 Aug. 2004 - ダイオキシンによるヒト正所性子官内膜プロゲステロン受容体PR‐B/PR‐A発現比低下作用
五十嵐敏雄; 江成大志; 金子英介; 川村久恵; 綾部琢哉; 堤治; 武谷雄二; BRUNER‐TRAN K; OSTEEN K G
エンドメトリオーシス研究会会誌, Jul. 2004 - Evidence for the presence of angiogenin in human testis
K Koga; Y Osuga; T Yano; Y Ikezuki; O Yoshino; Y Hirota; T Hirata; S Horie; T Ayabe; O Tsutsumi; Y Taketani
JOURNAL OF ANDROLOGY, May 2004 - Evidence for the presence of angiogenin in human testis
K Koga; Y Osuga; T Yano; Y Ikezuki; O Yoshino; Y Hirota; T Hirata; S Horie; T Ayabe; O Tsutsumi; Y Taketani
JOURNAL OF ANDROLOGY, May 2004 - 子宮内膜症患者群の正所性子宮内膜におけるプロゲステロン受容体PR‐B/PR‐A発現比(微量ダイオキシン処理後子宮内膜との類似性)
五十嵐敏雄; 江成大志; 金子英介; 川村久恵; 中川圭介; 山藤晶子; 綾部琢哉; 堤治; 武谷雄二
日本産科婦人科学会雑誌, 01 Feb. 2004 - ダイオキシンによるヒト子宮内膜プロゲステロン受容体発現比PR‐B/PR‐Aの低下効果
五十嵐敏雄; LIANG S‐G; 綾部琢哉; 堤治; 武谷雄二; EDWARDS D P; LESSEY B A; EISENBERG E; BRUNER‐TRAN K L
日本内分泌かく乱化学物質学会研究発表会要旨集, 02 Dec. 2003 - Possible roles of thrombin-induced activation of protease-activated receptor 1 in human luteinized granulosa cells
Y Hirota; Y Osuga; O Yoshino; K Koga; T Yano; T Hirata; E Nose; T Ayabe; A Namba; O Tsutsumi; Y Taketani
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Aug. 2003 - Endometrial stromal cells undergoing decidualization down-regulate their properties to produce proinflammatory cytokines in response to interleukin-1 beta via reduced p38 MAPK phosphorylation
Y. Osamu; O. Yutaka; H. Yasushi; H. Tetsuya; K. Kaori; Y. Tetsu; T. Osamu; T. Yuji
HUMAN REPRODUCTION, Jun. 2003 - Endometrial stromal cells undergoing decidualization down-regulate their properties to produce proinflammatory cytokines in response to interleukin-1 beta via reduced p38 MAPK phosphorylation
Y. Osamu; O. Yutaka; H. Yasushi; H. Tetsuya; K. Kaori; Y. Tetsu; T. Osamu; T. Yuji
HUMAN REPRODUCTION, Jun. 2003 - 若年性不正出血 (特集 病状からみた治療法の選択)
Jan. 2003 - Estrogen receptor-mediated effects of tamoxifen on human endometrial cancer cells
T Sakamoto; H Eguchi; Y Omoto; T Ayabe; H Mori; S Hayashi
MOLECULAR AND CELLULAR ENDOCRINOLOGY, Jun. 2002 - Estrogen receptor-mediated effects of tamoxifen on human endometrial cancer cells
T Sakamoto; H Eguchi; Y Omoto; T Ayabe; H Mori; S Hayashi
MOLECULAR AND CELLULAR ENDOCRINOLOGY, Jun. 2002 - 若年者の月経困難症の管理 (特集 若年者のante-pregnant care)
Feb. 2002 - A case of fibrosarcoma of ovary, difficult to differential diagnosed with uterine tumor
TAKESHITA Shigeki; SATHO Tomoyuki; KOIZUMI Hitoshi; FURUYA Ushio; MURASE Takayuki; AYABE Takuya; MORI Hiroyuki; IMAMURA Tetsuo
25 Oct. 2001 - P-454 早産前期破水搬送例の検討
2001 - Obstetrical Data On-line Registration (ODOR) on the web
KIDO Koichiro; TAKAHASHI Shin-ichiro; SASAMORI Yukihumi; TAKADA Shin-ichi; AYABE Takuya; MORI Hiroyuki; KOMATSU Junko
23 Nov. 2000 - Cystic Adenomyosis Diagnosed by Magnetic Resonance Imaging and Sonohysterography - A Case Report
TAKAHASHI Yuko; AYABE Takuya; TAKESHITA Shigeki; MORI Hiroyuki
2000
Cystic lesions of the uterus are rare. Here we report a case of cystic adenomyosis in a 32-year-old woman with severe menorrhagia for two years. Ultrasonography, sonohysterography and Magnetic Resonance imaging contributed to the preoperative diagnosis. The serum concentrarion of CA125 was 26.0 U / ml. The cyst was removed by laparotomy. On bisecting the uterine fundus, a 4 cm diameter cyst was found within the uterine cavity, attached to the uterus by a pedicle 1.5 cm in diameter. The wall of the chocolate-colored fluid-filled cyst was formed by myometrium, which was surrounded by the endometrium and was lined by endometrial tissue including glands and stroma. - Severe 5-fluorouracil-induced toxicity due to decreased dihydropyrimidine dehydrogenase activity: Report of a patient survival and urinary pyrimidine and dihydropyrimidine levels
Kazuyoshi Dobashi; Eiichi Ohe; Kazuko Yamaguchi; Shigeki Takeshita; Takuya Ayabe; Michio Miyazaki; Kiyoshi Kidouchi; Satoshi Sumi; Shoichi Okinaga; Hiroyuki Mori
International Journal of Clinical Oncology, Aug. 1999 - Recurrence rate at one year after the treatment of endometriosis by nasal administration of buserelin acetate : multicentral study in Japan.
Gynecological Endocrinology, 1999 - Increased circulating levels of insulin-like growth factor-I and decreased circulating levels of insulin-like growth factor binding protein-1 in postmenopausal women with endometrial cancer
T Ayabe; O Tsutsumi; H Sakai; H Yoshikawa; T Yano; F Kurimoto; Y Taketani
ENDOCRINE JOURNAL, Jun. 1997 - Temporal patterns of gene expression of G1-S cyclins and cdks during the first and second mitotic cell cycles in mouse embryos
GD Moore; T Ayabe; GS Kopf; RM Schultz
MOLECULAR REPRODUCTION AND DEVELOPMENT, Nov. 1996 - GnRHアンタゴニスト
01 Apr. 1996 - G1-S CYCLINS AND CDKS - TEMPORAL PATTERNS OF GENE-EXPRESSION DURING THE FIRST AND 2ND MITOTIC CELL-CYCLES OF MOUSE EMBRYOS
GD MOORE; T AYABE; GS KOPF; RM SCHULTZ
MOLECULAR BIOLOGY OF THE CELL, Nov. 1995 - REGULATION OF MOUSE EGG ACTIVATION - PRESENCE OF RYANODINE RECEPTORS AND EFFECTS OF MICROINJECTED RYANODINE AND CYCLIC ADP RIBOSE ON UNINSEMINATED AND INSEMINATED EGGS
T AYABE; GS KOPF; RM SCHULTZ
DEVELOPMENT, Jul. 1995 - Hexokinase Is a Key Enzyme of Glucose Metabolism Expressed during Preimplantation Mouse Development
Masashi Takami; Takeshi Takami; Hideki Sakamoto; Kazuo Satoh; Osamu Tsutsumi; Takuya Ayabe; Yutaka Morita; Yuji Taketani
Journal of Mammalian Ova Research, 1995 - ROLES OF HETEROTRIMERIC AND MONOMERIC G-PROTEINS IN SPERM-INDUCED ACTIVATION OF MOUSE EGGS
GD MOORE; T AYABE; PE VISCONTI; RM SCHULTZ; GS KOPF
DEVELOPMENT, Nov. 1994 - SPERM-INDUCED ACTIVATION OF MOUSE EGGS - ROLE OF HETEROTRIMERIC SAD MONOMERIC G-PROTEINS
GD MOORE; T AYABE; GS KOPF; RM SCHULTZ
DEVELOPMENTAL BIOLOGY, Jun. 1994 - IMPAIRED FOLLICULAR-GROWTH AND ABNORMAL LUTEINIZING-HORMONE SURGE IN LUTEAL-PHASE DEFECT
T AYABE; O TSUTSUMI; M MOMOEDA; T YANO; N MITSUHASHI; Y TAKETANI
FERTILITY AND STERILITY, Apr. 1994 - HEXOKINASE-ACTIVITY IN MOUSE EMBRYOS DEVELOPED IN-VIVO AND IN-VITRO
T AYABE; O TSUTSUMI; Y TAKETANI
HUMAN REPRODUCTION, Feb. 1994 - STIMULATORY EFFECT OF EPIDERMAL GROWTH-FACTOR ON THE DEVELOPMENT OF MOUSE EARLY EMBRYOS INVITRO
TM KUO; Y TAKETANI; T AYABE; O TSUTSUMI; M MIZUNO
ENDOCRINOLOGIA JAPONICA, Oct. 1991 - 16 Influence of Epidermal Growth Factor (EGF) on the Development of Mouse Embryos. :
kuo T.; Taketani Y.; Ayabe T.; Tsutsumi O.; Mizuno M.
1990 - 480 A possible role of progesterone on the RNA synthesis of mouse preimplantation embryo. :
Ayabe T.; Tsutsumi O.; Yano T.; Fujiwara T.; Mitsuhashi N.; Mizuno M.
1989 - 48. Possible Autocrine Function of Progesterone (P_4) in the Preimplantation Development of Mouse Embryo :
AYABE T.; TSUTSUMI O.; YANO T.; MITSUHASHI N.; MIZUNO M.
1988 - Effects of EGF on Oocyte Maturation in vitro :
Yano T; Taketani Y; Tsutsumi O; Ayabe T; Satoh K; Mizuno M
1987 - 哺乳動物卵子の成熟機構の生化学的研究
Jul. 1986 - 417. A Possible Stimulatory Role of Progesterone in Oocyte Maturation :
AYABE T.; TSUTSUMI O.; YANO T.; KITAGAWA H.; TAKAGI K.; MIZUNO M.; SATO K.
1986 - 210. Prostaglandin Metabolism in the Oocyte and Oocyte-cumulus Complex and its Significance in Oocyte Maturation :
TSUTSUMI O; YANO T; ISHIHARA O; AYABE T; KINOSHITA K; SATHO K; MIZUNO M
1985
Books and other publications
- 産婦人科研修ノート改訂第2版
Joint editor
2014 - 産婦人科研修の必修知識2013
Contributor
2013 - 標準産科婦人科学 第４版第２刷
Joint editor
2013 - 子宮筋腫・子宮内膜症・子宮腺筋症 診療マニュアル
Contributor
2013 - 生殖卵巣学
Contributor
2011 - 標準産科婦人科学 第４版
Joint editor
2011 - 生殖医療ガイドブック
Contributor
2010 - 産婦人科研修ノート
Joint editor
2009 - 生殖医療ガイドライン
Contributor
2007 - NEW産婦人科学改訂第２版
Contributor
2004 - 標準産科婦人科学第３版
Contributor
2004
Research Themes
- 子宮頸部円錐切除後の妊孕性
2006 - 胎動計による胎児運動の計測
2006 - Cervical mucus after conization of uterine cervix
2006 - New approach for fetal movement
2006 - 子宮内胎児発育遅延と胎内環境
2004 - 妊娠経過中の血液凝固線溶能
2004 - 子宮外妊娠の簡易診断法
2004 - 婦人科悪性腫瘍の傍大動脈リンパ節転移診断
2004 - Intrauterine growth retardation and in-utero environment
2004 - Coagulation and fibrinolysis during pregnancy
2004 - Prompt diagnosis of ectopic pregnancy
2004 - Diagnosis of para-aortic lymph node metastasis in gynecologic malignancy
2004 - 子宮頚管粘膜免疫
2002 - mucous membrane immunology of the uterine cervix
2002
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