Sep. 2017

Decreased non-emotional working memory capacity in women with PTSD: association with symptomatology.
Natsuki Ueda; Mingming Lin; Mariko Itoh; Hiroaki Hori; Zui Narita; Madoka Niwa; Keiko Ino; Megumi Narita; Wakako Nakano; Risa Imai; Mie Matsui; Toshiko Kamo; Yoshiharu Kim
European journal of psychotraumatology, Dec. 2025, [Reviewed]
Background/objective: Posttraumatic stress disorder (PTSD) is known to be associated with deficits in working memory (WM). However, findings regarding the relationship of PTSD with non-emotional WM have not necessarily been uniform. This study aimed to clarify the relationship between PTSD and non-emotional WM using the N-back task, a well-established WM task.Method: A total of 111 women with PTSD and 120 healthy control women without trauma were enrolled. Most of the patients developed PTSD after experiencing interpersonal violence. Participants completed 0-back and 2-back tasks using non-emotional stimuli (number), as well as a standardised neuropsychological test battery and self-report questionnaires for PTSD and depression symptoms.Results: The PTSD group showed significantly less accuracy in the 2-back task than the control group, while no significant difference was observed in the accuracy of the 0-back task. The PTSD group showed significantly prolonged reaction time compared to controls in both the 0-back and 2-back tasks. The prolonged reaction time in the 2-back task was significantly correlated with more severe overall symptoms and avoidance symptoms in the PTSD group after controlling for age.Conclusion: Individuals with PTSD exhibited reduced WM capacity. Drawing on a relatively large civilian sample, this study contributes to the accumulating evidence of such deficits. Notably, the observed association between WM dysfunction and avoidance symptoms suggests a symptom-specific cognitive profile in PTSD.

Can generative AI assess PTSD? A clinical validation study of transcribed and direct audio input modalities
Zui C Narita; Joseph R Ledsam; Madoka Niwa; Nobuo Kawada; Isaac R Galatzer-Levy; Yoshiharu Kim
BMJ Digital Health & AI, 06 Aug. 2025, [Reviewed]
Objective

Post-traumatic stress disorder (PTSD) remains underdiagnosed due to barriers such as limited access to mental health professionals and resource constraints. While generative artificial intelligence (AI) shows potential in mental health applications, little information is available on its ability to assess PTSD, particularly through direct audio input. We aimed to examine the ability of three AI-based input modalities to support clinical diagnosis of PTSD: Claude 3.5 Sonnet with transcribed input, Gemini 1.5 Pro with transcribed input and Gemini 1.5 Pro with direct audio input.

Methods and analysis

Participants were adults with trauma histories who completed clinical interviews. Both generative AI and clinicians produced continuous severity scores and binary diagnoses. For diagnostic prediction, AI-generated severity scores were compared with binary clinician diagnoses using receiver operating characteristic curve analysis to compute area under the curve (AUC). Reliability between AI and clinician severity scores was evaluated using intraclass correlation coefficients (ICCs). Accuracy was calculated by comparing AI-generated diagnoses to clinician-rated diagnoses.

Results

The study included 53 participants (mean age=36.9 years, SD=10.6); 47 were female (88.7%). 37 participants (69.8%) met PTSD criteria based on clinician diagnosis. AUCs, ICCs and accuracies (95% CIs) were: Claude transcribed input, 0.94 (0.87 to 1.00), 0.82 (0.71 to 0.92) and 0.89 (0.78 to 0.95); Gemini transcribed input, 0.93 (0.85 to 1.00), 0.83 (0.73 to 0.90) and 0.85 (0.74 to 0.93); Gemini direct audio input, 0.93 (0.84 to 1.00), 0.89 (0.81 to 0.93) and 0.80 (0.68 to 0.90).

Conclusions

Generative AI may support PTSD diagnosis and expand access to care. Future applications should be developed with an emphasis on privacy-preserving deployment.

Neurocognitive functioning over the course of STAIR Narrative Therapy for ICD-11 complex PTSD
Madoka Niwa; Tomoko Kato; Yosuke Suga; Rieko Otomo; Mayumi Sugawara; Mie Matsui; Toshiko Kamo; Hiroaki Hori; Yoshiharu Kim
European Journal of Psychotraumatology, 14 Jul. 2025, [Reviewed]

Serum lipid and plasma fatty acid profiles in PTSD patients and healthy individuals: Associations with symptoms, cognitive function, and inflammatory markers.
Shintaro Ogawa; Hiroaki Hori; Madoka Niwa; Mariko Itoh; Mingming Lin; Fuyuko Yoshida; Keiko Ino; Hitomi Kawanishi; Megumi Narita; Wakako Nakano; Risa Imai; Mie Matsui; Toshiko Kamo; Hiroshi Kunugi; Kotaro Hattori; Yoshiharu Kim
Progress in neuro-psychopharmacology & biological psychiatry, 21 Feb. 2025, [Reviewed]
Increasing evidence suggests that posttraumatic stress disorder (PTSD), a serious mental health condition, is associated with physical health problems. Lipid-related molecules are crucial for central nervous system functions associated with PTSD symptoms; however, case-control studies exploring the relationship between PTSD and lipid-related molecules are scarce. We examined 68 civilian PTSD patients and 97 healthy controls, evaluating PTSD symptoms, childhood maltreatment history, suicidality, and cognitive functions. Cholesterol, triglycerides, and inflammation-related marker levels were analyzed in serum, while fatty acid levels were measured in plasma. Compared to controls, patients exhibited significantly lower high-density lipoprotein cholesterol and n-6 linoleic acid levels, alongside higher saturated palmitic acid levels and the triene-to-tetraene (T/T) ratio. PTSD symptoms, particularly hyperarousal, were significantly positively correlated with n-6 γ-linolenic, n-6 dihomo-γ-linolenic, and n-9 mead acid levels, and the T/T ratio. Cognitive functions were significantly positively correlated with n-3 docosahexaenoic acid and total n-3 fatty acid levels, and negatively correlated with dihomo-γ-linolenic, palmitic, and total saturated fatty acid levels. Suicidality was significantly positively correlated with dihomo-γ-linolenic acid, mead acid levels, and the T/T ratio, and negatively correlated with polyunsaturated fatty acid (PUFA) levels. Inflammation-related marker levels were significantly correlated with higher palmitic, n-9 oleic, and total n-9 fatty acid levels, and lower linoleic acid and PUFA levels. Latent profile analysis (LPA) revealed distinct subgroups associated with unique fatty acid profiles. These lipid-related alterations may improve the understanding of PTSD pathophysiology. Distinct fatty acid profiles identified by LPA may help subtype PTSD patients and guide nutrition-based personalized treatment strategies.

Psychotherapy for posttraumatic stress disorder
Niwa Madoka
Stress Science Research, 2025, [Reviewed]
Clinical practice guidelines for posttraumatic stress disorder (PTSD) from various agencies recommend trauma-focused psychotherapies as the first-line treatment. Commonly recommended therapies include Prolonged Exposure Therapy, Cognitive Processing Therapy, and Eye Movement Desensitization and Reprocessing. After introducing the core elements of empirically supported psychotherapies for PTSD, this paper focuses first on Prolonged Exposure Therapy, which has been covered by health insurance in Japan since 2016, explaining its theoretical foundation and treatment details. The second half of the paper addresses therapeutic approaches for complex PTSD, newly adopted in the International Classification of Diseases, 11th Revision (ICD-11). Given the more pervasive and multifaceted nature of complex PTSD, treatment guidelines recommend integrating multiple therapeutic components to address these broader challenges. Trauma-focused therapies may need to be adapted to accommodate the specific needs of individuals with complex PTSD. In this context, the paper introduces Skills Training in Affective and Interpersonal Regulation (STAIR) Narrative Therapy, a multicomponent therapeutic model specifically designed for complex PTSD.

Suicidality in civilian women with PTSD: Possible link to childhood maltreatment, proinflammatory molecules, and their genetic variations
Hitomi Kawanishi; Hiroaki Hori; Fuyuko Yoshida; Mariko Itoh; Mingming Lin; Madoka Niwa; Megumi Narita; Takeshi Otsuka; Keiko Ino; Risa Imai; Shin Fukudo; Toshiko Kamo; Hiroshi Kunugi; Yoshiharu Kim
Brain, Behavior, & Immunity - Health, Jul. 2023, [Reviewed]

Skills Training in Affective and Interpersonal Regulation Narrative Therapy for women with ICD-11 complex PTSD related to childhood abuse in Japan: a pilot study
Madoka Niwa; Tomoko Kato; Ryoko Narita-Ohtaki; Rieko Otomo; Yosuke Suga; Mayumi Sugawara; Zui Narita; Hiroaki Hori; Toshiko Kamo; Yoshiharu Kim
European Journal of Psychotraumatology, 08 Jun. 2022, [Reviewed]
Background: Skills Training in Affective and Interpersonal Regulation (STAIR) Narrative Therapy (SNT) has shown efficacy in alleviating symptoms of posttraumatic stress disorder (PTSD) and improving emotion regulation and interpersonal skills among individuals with complex trauma, such as childhood abuse. Although this therapy is expected to be effective for patients with complex PTSD (CPTSD), no study has directly assessed diagnostic and symptom outcomes. Moreover, the potential of therapy to achieve good outcomes in non-Western countries remains unclear. Objective: This pilot study examined the feasibility, safety, and outcomes of SNT for CPTSD among women with a history of childhood abuse in a Japanese clinical setting. Methods: Ten women aged 21-54 years (M = 29.1 years) with childhood-abuse-related ICD-11 CPTSD were enrolled in this study. The International Trauma Interview and International Trauma Questionnaire were administered to diagnose CPTSD and assess its severity. Symptoms of dissociation and depression, difficulties in emotion regulation and interpersonal relationships, quality of life, and negative cognitions were assessed pretreatment, midtreatment (after the STAIR phase), and immediately posttreatment (after the Narrative Therapy phase), in addition to 3 months after treatment. Results: Seven of the 10 participants completed the treatment. The therapists' adherence to the therapy protocol was 96.4%, ranging from 93.6% to 100% across therapists. Serious adverse events were not observed. Among the seven completers, six at posttreatment and all at follow-up no longer met CPTSD diagnosis. Exploratory analyses using the linear mixed-effects model showed significant improvements at posttreatment and follow-up for almost all the variables. Conclusions: The results provide preliminary evidence for the feasibility and safety of SNT for CPTSD in a Japanese clinical setting. This study is the first to report the use of SNT for individuals diagnosed with ICD-11 CPTSD using reliable clinician and self-report measures. HIGHLIGHTS: This study examined the feasibility and safety of STAIR Narrative Therapy for women with ICD-11 CPTSD related to childhood abuse in a Japanese clinical setting.High therapy adherence was observed.No serious adverse events occurred.

Hypothalamic-pituitary-adrenal axis and renin-angiotensin-aldosterone system in adulthood PTSD and childhood maltreatment history.
Ryoko Kakehi; Hiroaki Hori; Fuyuko Yoshida; Mariko Itoh; Mingming Lin; Madoka Niwa; Megumi Narita; Keiko Ino; Risa Imai; Daimei Sasayama; Toshiko Kamo; Hiroshi Kunugi; Yoshiharu Kim
Frontiers in psychiatry, 2022, [Reviewed]
Accumulated evidence shows that psychological trauma and posttraumatic stress disorder (PTSD) are associated with dysfunction in the hypothalamic-pituitary-adrenal (HPA) axis. Besides the HPA axis hormones, recent evidence suggests that the renin-angiotensin-aldosterone (RAA) system and genetic factors may be involved in trauma/PTSD as well as in HPA axis regulation. This study attempted to better understand the HPA axis function in relation to PTSD and childhood maltreatment by simultaneously examining RAA system and genetic polymorphisms of candidate genes. Here we studied 69 civilian women with PTSD and 107 healthy control women without DSM-IV-based traumatic experience. Childhood maltreatment history was assessed with the Childhood Trauma Questionnaire. PTSD severity was assessed with the Posttraumatic Diagnostic Scale. Functional disability was assessed with the Sheehan Disability Scale. HPA axis was examined by measuring blood levels of cortisol, adrenocorticotropic hormone, and dehydroepiandrosterone-sulphate (DHEA-S). RAA system was examined by measuring blood renin and aldosterone levels. The FKBP5 rs1360780 and CACNA1C rs1006737 polymorphisms were genotyped. No significant differences were seen between patients and controls in any of the five hormone levels. DHEA-S levels were significantly negatively correlated with overall PTSD severity (p = 0.003) and functional disability (p = 0.008). A two-way analysis of variance with diagnostic groups and genotypes as fixed factors revealed that patients with the rs1006737 A-allele had significantly lower DHEA-S levels than patients with the GG genotype (p = 0.002) and controls with the A-allele (p = 0.006). Childhood maltreatment history was not significantly correlated with any of the five hormone levels. These results were generally unchanged after controlling for the potentially confounding effect of age, depression, and anxiety. Our findings suggest that lower DHEA-S levels could indicate more severe subtype of PTSD, the association of which might be partly modified by the CACNA1C polymorphism.

Japanese Version of the Eyberg Child Behavior Inventory: Translation and Validation
Toshiko Kamo; Fumie Ito; Yukifumi Monden; Regina Bussing; Madoka Niwa; Masako Kawasaki; Miyuki Matano; Yuri Ujiie; Yuko Higaki; Yuka Oe; Nobuaki Morita; Yoshiharu Kim; Elizabeth Brestan Knight; Sheila Eyberg
Japanese Psychological Research, 05 Jun. 2021, [Reviewed]

Childhood maltreatment history and attention bias variability in healthy adult women: role of inflammation and the BDNF Val66Met genotype.
Hiroaki Hori; Mariko Itoh; Mingming Lin; Fuyuko Yoshida; Madoka Niwa; Yuko Hakamata; Mie Matsui; Hiroshi Kunugi; Yoshiharu Kim
Translational psychiatry, 11 Feb. 2021, [Reviewed]
Childhood maltreatment has been associated with greater attention bias to emotional information, but the findings are controversial. Recently, a novel index of attention bias, i.e., attention bias variability (ABV), has been developed to better capture trauma-related attentional dysfunction. However, ABV in relation to childhood trauma has not been studied. Here, we examined the association of childhood maltreatment history with attention bias/ABV in 128 healthy adult women. Different types of childhood maltreatment were assessed with the Childhood Trauma Questionnaire. Attention bias/ABV was measured by the dot-probe task. Possible mechanisms whereby childhood maltreatment affects attention bias/ABV were also explored, focusing on blood proinflammatory markers and the BDNF Val66Met polymorphism. We observed a significant positive correlation between childhood emotional abuse and ABV (P = 0.002). Serum high-sensitivity tumor necrosis factor-α levels were significantly positively correlated with ABV (P < 0.001), but not with childhood maltreatment. Jonckheere-Terpstra trend test showed a significant tendency toward greater ABV with increasing numbers of the BDNF Met alleles (P = 0.021). A two-way analysis of variance further revealed that the genotype-by-emotional abuse interaction for ABV was significant (P = 0.022); individuals with the Val/Met and Met/Met genotypes exhibited even greater ABV when childhood emotional abuse was present. These results indicate that childhood emotional abuse can have a long-term negative impact on emotional attention control. Increased inflammation may be involved in the mechanism of ABV, possibly independently of childhood maltreatment. The BDNF Met allele may dose-dependently increase ABV by interacting with childhood emotional abuse.

Association of CRP genetic variation with symptomatology, cognitive function, and circulating proinflammatory markers in civilian women with PTSD.
Takeshi Otsuka; Hiroaki Hori; Fuyuko Yoshida; Mariko Itoh; Mingming Lin; Madoka Niwa; Keiko Ino; Risa Imai; Sei Ogawa; Mie Matsui; Toshiko Kamo; Hiroshi Kunugi; Yoshiharu Kim
Journal of affective disorders, 01 Nov. 2020, [Reviewed]
BACKGROUND: Posttraumatic stress disorder (PTSD) has been associated with increased inflammation. C-reactive protein (CRP) is a marker of systemic inflammation, and recently, single nucleotide polymorphisms (SNPs) in the CRP gene have been associated with increased blood CRP protein levels and illness severity in PTSD patients. However, the mechanism by which the CRP SNPs are involved in PTSD remains unclear. Here we investigated the association of CRP genetic variation with blood proinflammatory protein levels, symptomatology, and cognitive function, and further explored the moderating effect of childhood maltreatment history, in adult patients with PTSD. METHODS: Fifty-seven Japanese civilian women with PTSD and 73 healthy control women were enrolled. Three SNPs in the CRP gene, namely rs2794520, rs1130864, and rs3093059, were genotyped, and analyses focused on rs2794520 (T/C). Serum levels of high-sensitivity CRP (hsCRP), high-sensitivity tumor necrosis factor-α (hsTNF-α), and interleukin-6 were measured. PTSD symptoms were evaluated by the Posttraumatic Diagnostic Scale. Cognitive function was assessed by the Repeatable Battery for the Assessment of Neuropsychological Status. Childhood maltreatment history was assessed by the Childhood Trauma Questionnaire. RESULTS: Patients with the rs2794520 CC/CT genotype, compared to those with the TT genotype, showed significantly higher levels of hsCRP (p=0.009) and hsTNF-α (p=0.001), more severe PTSD symptoms (p=0.036), and poorer cognitive function (p=0.018). A two-way analysis of variance revealed a significant genotype-by-maltreatment interaction for more severe PTSD avoidance symptom (p=0.012). LIMITATIONS: The relatively small sample size limited our findings. CONCLUSIONS: These findings may provide an insight into the etiology of PTSD from the inflammatory perspective.

The BDNF Val66Met polymorphism affects negative memory bias in civilian women with PTSD.
Hiroaki Hori; Mariko Itoh; Fuyuko Yoshida; Mingming Lin; Madoka Niwa; Yuko Hakamata; Keiko Ino; Risa Imai; Sei Ogawa; Mie Matsui; Toshiko Kamo; Hiroshi Kunugi; Yoshiharu Kim
Scientific reports, 21 Feb. 2020, [Reviewed]
Memory abnormalities are considered a core feature of posttraumatic stress disorder (PTSD). Studies attempting to quantify such memory dysfunction in PTSD have reported that individuals with this disorder exhibit selective memory bias toward negative material. The low expression Met allele of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism has been associated with the aetiology of PTSD and with memory abnormalities. It is therefore possible that the BDNF Val66Met polymorphism can moderate the relationship between PTSD and memory bias. Here we examined this association in 50 civilian women with PTSD and 70 non-trauma-exposed healthy control women. All subjects were genotyped for the BDNF Val66Met (rs6265) polymorphism. Negative memory bias was assessed using a recognition memory task. Patients showed significantly greater negative memory bias compared to controls. In patients, negative memory bias significantly increased with increasing numbers of Met alleles; while no significant relationship was seen in controls. Further pairwise analyses revealed that patients with the Met allele had significantly greater negative memory bias than controls. These results suggest that the relationship between PTSD and negative memory bias can be moderated by the BDNF Val66Met polymorphism. More studies are needed to further clarify the relationship between this polymorphism and memory abnormalities in PTSD.

Possible Long-Term Effects of Childhood Maltreatment on Cognitive Function in Adult Women With Posttraumatic Stress Disorder.
Michi Nakayama; Hiroaki Hori; Mariko Itoh; Mingming Lin; Madoka Niwa; Keiko Ino; Risa Imai; Sei Ogawa; Atsushi Sekiguchi; Mie Matsui; Hiroshi Kunugi; Yoshiharu Kim
Frontiers in psychiatry, 2020, [Reviewed]
Accumulated evidence shows that individuals with posttraumatic stress disorder (PTSD) have compromised cognitive function. PTSD is associated with childhood maltreatment, which also can negatively affect cognitive function. It is therefore possible that cognitive dysfunction in adult patients with PTSD can be due at least partly to childhood maltreatment, although little is documented on this issue. Here we aimed to examine the possible effect of childhood maltreatment on cognitive function in adult patients with PTSD. A total of 50 women with DSM-IV PTSD and 94 healthy control women were enrolled. Most of the patients developed PTSD after experiencing interpersonal violence during adulthood. History of childhood maltreatment was assessed using the Childhood Trauma Questionnaire (CTQ). Cognitive functions were assessed by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Compared to controls, patients reported significantly more experiences of all types of childhood maltreatment as assessed by the CTQ and showed significantly poorer performance on immediate memory, language, attention, and the total score of RBANS. In patients, sexual abuse scores were significantly negatively correlated with RBANS language (p < 0.001) and total score (p = 0.005). Further analyses revealed that PTSD patients with childhood sexual abuse had even poorer cognitive function than those without the abuse. In controls, no significant correlation was found between CTQ and RBANS scores. These results suggest that childhood maltreatment, specifically sexual abuse, may lead to persistent cognitive impairment in individuals with PTSD. Our findings might underscore the importance of early detection and intervention of childhood maltreatment, which will be achieved by careful observation of, and listening to, maltreated children in education and welfare scenes as well as clinical settings.

Proinflammatory status-stratified blood transcriptome profiling of civilian women with PTSD.
Hiroaki Hori; Fuyuko Yoshida; Mariko Itoh; Mingming Lin; Madoka Niwa; Keiko Ino; Risa Imai; Sei Ogawa; Mie Matsui; Toshiko Kamo; Hiroshi Kunugi; Yoshiharu Kim
Psychoneuroendocrinology, Jan. 2020, [Reviewed]
Etiology of posttraumatic stress disorder (PTSD) remains largely unknown. Studies have shown that a significant subset of patients with PTSD exhibit increased inflammation, suggesting that the understanding of this disorder could be facilitated by classifying these patients by inflammatory status. Here we performed a microarray-based blood transcriptome analysis on proinflammatory status-stratified Japanese civilian women with PTSD most of whom developed the disorder after experiencing interpersonal violence. By utilizing our previously identified cut-off serum interleukin-6 (IL-6) level that approximately corresponded to the median IL-6 level of our PTSD patients, we classified patients into those with high IL-6 levels and those with normal IL-6 levels (n = 16 for each). Transcriptome profiles of these 2 groups were compared with the profile of 16 age-matched healthy control women. Differentially expressed genes between high IL-6 patients and controls showed significant enrichment in a number of gene ontology terms and pathways primarily involved in immune/inflammatory responses, and their protein-protein interaction network was significantly enriched. In contrast, differentially expressed genes between normal IL-6 patients and controls showed significant enrichment in several gene ontology terms related to ion transport and neural function. The microarray data were confirmed by reverse transcription quantitative PCR. These findings illustrate the heterogeneous molecular mechanisms of PTSD within this relatively homogeneous sample in terms of sex, trauma type, and ethnicity, suggesting that peripheral proinflammatory status such as IL-6 levels could be a useful subtyping marker for this disorder. With further research, it is hoped that our findings will be translated into personalized medicine.

Relationships of blood proinflammatory markers with psychological resilience and quality of life in civilian women with posttraumatic stress disorder.
Risa Imai; Hiroaki Hori; Mariko Itoh; Mingming Lin; Madoka Niwa; Keiko Ino; Sei Ogawa; Atsushi Sekiguchi; Hiroshi Kunugi; Tatsuo Akechi; Toshiko Kamo; Yoshiharu Kim
Scientific reports, 29 Nov. 2019, [Reviewed]
Individuals with posttraumatic stress disorder (PTSD) show low resilience and impaired quality of life (QOL). Accumulating evidence shows that PTSD is associated with increased inflammation. Studies suggest that inflammation can be a key mechanism underlying low resilience/QOL, but this relationship has been understudied in individuals with PTSD. Here, we investigated the association of blood proinflammatory markers with self-reported resilience and QOL in civilian women with PTSD. Fifty-six women with PTSD and 73 healthy control women participated in this study. Resilience was assessed using the Connor-Davidson Resilience Scale. QOL was assessed using the World Health Organization Quality of Life-BREF. Blood samples were collected for the measurement of three proinflammatory markers including interleukin-6 (IL-6), high-sensitivity tumor necrosis factor-α, and high-sensitivity C-reactive protein (hsCRP). Compared to controls, patients showed significantly higher IL-6 levels and lower resilience and QOL. In patients, IL-6 levels were significantly negatively correlated with resilience, and hsCRP levels were significantly negatively correlated with psychological QOL. These results show that increased levels of proinflammatory markers including IL-6 and hsCRP are associated with lower psychological resilience and QOL in PTSD patients. Our findings suggest that interventions and treatments targeting inflammation may aid in the recovery from PTSD and lead to better prognosis.

Augmentation of Positive Valence System-Focused Cognitive Behavioral Therapy by Inaudible High-Frequency Sounds for Anhedonia: A Trial Protocol for a Pilot Study.
Masaya Ito; Mitsuhiro Miyamae; Chika Yokoyama; Yuichi Yamashita; Osamu Ueno; Kazushi Maruo; Asami Komazawa; Madoka Niwa; Manabu Honda; Masaru Horikoshi
JAMA network open, 01 Nov. 2019, [Reviewed]
Importance: Recent conceptualizations in Research Domain Criteria have indicated that anhedonia, 1 of 2 core symptoms of depression, which can be treatment resistant, is associated with deficits in the positive valence system, and inaudible high-frequency sound therapy has been shown to enhance reward-related brain circuitry. Hence, cognitive behavioral therapy focusing on the positive valence system enhanced with sound therapy could have a synergistic effect on anhedonia. Objective: To test the augmentation effect of inaudible high-frequency sounds on the efficacy of positive valence system-focused cognitive behavioral therapy to treat anhedonia. Design, Setting, and Participants: In this individual-level allocation, exploratory, single-center randomized superiority pilot trial, patients, therapists, and evaluators will be masked to intervention or placebo assignment. The trial will take place at a national psychiatric referral hospital in Tokyo, Japan, among 44 adult patients with clinically significant anhedonia and moderate to severe depression. Outcomes will be analyzed following the intent-to-treat principle using a repeated-measures mixed model. Intervention: The intervention group will participate in 8 weekly sessions of positive valence system-focused cognitive behavioral therapy with in-session exposure to an inaudible high-frequency sound; the comparison group will undergo cognitive behavioral therapy with in-session exposure to a placebo sound. Main Outcomes and Measures: The primary outcome is anhedonia assessed using the self-reported Snaith-Hamilton Pleasure Scale. The secondary outcome is anhedonia assessed using the clinician-administered version of the Snaith-Hamilton Pleasure Scale. Discussion: Recruitment for this study began in May 2018, and the projected date of final allocation is January 2020. A total of 21 eligible patients were registered for participation as of May 30, 2019. To date, treatments for depression do not guarantee clinically successful outcomes. This pilot trial will provide preliminary evidence of the augmentation effect of high-frequency inaudible sounds on cognitive behavioral therapy for anhedonia. Overall, exposure to an inaudible high-frequency sounds does not require attentional or cognitive effort from either patients or therapists; therefore, results from a future confirmative trial could indicate that cognitive behavioral therapy can be augmented in an effortless manner. Trial Registration: umin.ac.jp/ctr Identifier: UMIN000031948.

Memory bias and its association with memory function in women with posttraumatic stress disorder.
Mariko Itoh; Hiroaki Hori; Mingming Lin; Madoka Niwa; Keiko Ino; Risa Imai; Sei Ogawa; Mie Matsui; Toshiko Kamo; Yoshiharu Kim
Journal of affective disorders, 15 Feb. 2019, [Reviewed]
BACKGROUND: Memory abnormalities are among a central feature of posttraumatic stress disorder (PTSD). It is suggested that individuals with PTSD exhibit memory bias; while evidence shows poor memory function in these individuals. We aimed to examine memory bias in PTSD patients relative to controls and to explore an association between memory bias and memory function. METHODS: Forty-six women with DSM-IV PTSD, most of whom developed the disorder after interpersonal violence, and 68 non-trauma-exposed healthy control women were studied. Memory bias was assessed by a recognition memory task using negative, neutral, and positive words. Memory function was assessed by a standardized neuropsychological test battery. Depression and anxiety symptoms were assessed by self-report measures. RESULTS: Compared to controls, patients showed significantly greater negative bias scores (i.e., correctly recognized rates for negative words minus those for neutral words) and poorer memory function. Negative bias scores were significantly correlated with worse memory function in patients. When patients were divided into those with lower vs. normal memory function, the former patients had significantly greater negative bias than the latter patients and controls. Memory bias scores in patients were not significantly correlated with depression or anxiety symptoms, nor were they significantly different between patients with comorbid major depressive disorder and those without. LIMITATIONS: The cross-sectional design and absence of the trauma-exposed non-PTSD group limited our findings. CONCLUSIONS: PTSD patients have greater negative memory bias, which can be associated with poorer memory function. Our findings may provide an insight into the nature of memory abnormalities in PTSD.

Cognitive function in Japanese women with posttraumatic stress disorder: Association with exercise habits.
Ryoko Narita-Ohtaki; Hiroaki Hori; Mariko Itoh; Mingming Lin; Madoka Niwa; Keiko Ino; Risa Imai; Sei Ogawa; Atsushi Sekiguchi; Mie Matsui; Hiroshi Kunugi; Toshiko Kamo; Yoshiharu Kim
Journal of affective disorders, 15 Aug. 2018, [Reviewed]
BACKGROUND: Posttraumatic stress disorder (PTSD) has been associated with cognitive impairments, yet little is documented on the cognitive function of PTSD patients in Asian countries. It is shown that regular exercise can reduce PTSD symptoms, while no study has investigated the association between exercise and cognition in PTSD patients. This study aimed to examine cognitive functions of Japanese women with PTSD, and to explore the association between regular exercise and cognitive functions. METHODS: Forty-two women with DSM-IV PTSD and 66 demographically matched healthy control women participated in this study. Most of the patients developed PTSD after experiencing interpersonal violence. Cognitive functions were assessed by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Regular exercise habit was assessed by a self-reported questionnaire. RESULTS: Compared to controls, PTSD patients performed significantly more poorly in all cognitive domains examined, including immediate memory, visuospatial construction, language, attention, delayed memory, as well as the total score of RBANS (all p < 0.001). Compared to PTSD patients without the habit of exercise, those who habitually exercised showed significantly better performance on delayed memory (p = 0.006), which survived after controlling for potentially confounding variables in a multiple regression model. LIMITATIONS: The cross-sectional design and relatively small sample size limited our findings. CONCLUSIONS: PTSD in Japanese women is associated with pervasively impaired cognitive functions, including notable impairments in verbal memory. Such memory deficits might be improved by regular exercise, although further studies are needed to investigate the causal relationship between exercise and cognition in PTSD.

Inflammatory markers and their possible effects on cognitive function in women with posttraumatic stress disorder.
Risa Imai; Hiroaki Hori; Mariko Itoh; Mingming Lin; Madoka Niwa; Keiko Ino; Sei Ogawa; Makiko Ishida; Atsushi Sekiguchi; Mie Matsui; Hiroshi Kunugi; Tatsuo Akechi; Toshiko Kamo; Yoshiharu Kim
Journal of psychiatric research, Jul. 2018, [Reviewed]
Posttraumatic stress disorder (PTSD) has been associated with increased inflammation, albeit with some controversy. Another key feature of PTSD is compromised function in wide-ranging cognitive domains. Increased peripheral inflammation can contribute to cognitive dysfunction, although this relationship has not been studied in patients with PTSD. Here, we examined blood inflammatory markers in adult patients with PTSD compared to healthy controls taking account of potentially confounding effects of childhood maltreatment and comorbid major depressive disorder (MDD), and explored the association between inflammation and cognition. We enrolled 40 women with PTSD, most of whom developed the disorder after interpersonal violence during adulthood, and 65 healthy control women. Diagnoses were made based on DSM-IV. History of childhood maltreatment was assessed using the Childhood Trauma Questionnaire (CTQ). Cognitive function was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Blood samples were collected for the measurement of 5 inflammatory markers including interleukin-6 (IL-6), soluble IL-6 receptor, interleukin-1β, high-sensitivity tumor necrosis factor-α, and high-sensitivity C-reactive protein. Compared to controls, patients with PTSD showed significantly higher IL-6 levels (p = 0.009) and lower scores on all RBANS domains (all p < 0.01). IL-6 levels in patients were not significantly associated with the presence/absence of comorbid MDD or CTQ scores. IL-6 levels in patients were significantly negatively correlated with RBANS visuospatial construction (p = 0.046), language (p = 0.008), attention (p = 0.036) and total score (p = 0.008). These results suggest that elevated IL-6 is associated with PTSD and that the lower cognitive function in PTSD may be due at least partly to increased inflammation.

Sexual Violence as a Key Contributor to Poor Mental Health Among Japanese Women Subjected to Intimate Partner Violence.
Tomoko Honda; Karen Wynter; Jinko Yokota; Thach Tran; Yuri Ujiie; Madoka Niwa; Michi Nakayama; Fumie Ito; Yoshiharu Kim; Jane Fisher; Toshiko Kamo
Journal of women's health (2002), May 2018, [Reviewed]
OBJECTIVES: The aim of this study was to examine the impact of sexual intimate partner violence (IPV) on mental health among Japanese women and to explore to what extent sexual IPV is an important contributor to the severity of mental health problems in comparison with physical and psychological IPV. MATERIALS AND METHODS: A cross-sectional analysis was conducted of the medical records of participants during psychiatric consultation at the Institute of Women's Health, Tokyo Women's Medical University, including 62 women who experienced IPV without sexual violence and 83 women who experienced IPV with sexual violence. Mental health problems were compared, including anxiety, depression, suicidality, post-traumatic stress disorder (PTSD), and dissociative experiences. RESULTS: The results demonstrated a higher incidence and severity of somatic symptoms, insomnia, social dysfunction, severe depression and suicidality, PTSD, and dissociative experiences among women in the sexual IPV group than in the women who experienced IPV without sexual violence. In analyzing the relative contribution of sexual, physical, and psychological violence to the severity of mental health problems of the survivors, results indicated that sexual violence was an independent predictor of both PTSD and dissociative experiences. CONCLUSIONS: The present research showed that significant adverse effects on mental health were observed among women who experienced IPV with sexual violence compared with the ones without. These findings provide important implications for considering the specific approaches to meet the needs of those women experiencing sexual IPV and the need for timely and effective interventions, including healthcare, social services, and primary prevention.

The Japanese version of the Posttraumatic Diagnostic Scale: Validity in participants with and without traumatic experiences.
Mariko Itoh; Yuri Ujiie; Nobukazu Nagae; Madoka Niwa; Toshiko Kamo; Mingming Lin; Sayuri Hirohata; Yoshiharu Kim
Asian journal of psychiatry, Feb. 2017, [Reviewed]
The Posttraumatic Diagnostic Scale (PDS) is a brief, self-report questionnaire developed for the diagnostic screening and assessment of the severity of posttraumatic stress disorder (PTSD); the PDS is based on the criteria outlined in the Diagnostic and Statistical Manual of Mental Disorders (4th edition; DSM-IV). We investigated the validity and reliability of the Japanese version of the PDS in a clinical (n=109) and a non-clinical (n=116) sample, recruited from an outpatient psychiatric facility and a university student population, respectively. The Japanese versions of the PDS and the Clinician-Administered PTSD Scale (CAPS/DSM-IV) were administered to the participants. The Japanese PDS's diagnostic sensitivity and specificity exceeded 90%. The correlation between the severity scores assessed by the Japanese PDS and the CAPS was also high (r=0.92). The findings suggest that the Japanese version of the PDS is useful for diagnostically screening PTSD and assessing symptom severity.

A new short version of the Posttraumatic Diagnostic Scale: validity among Japanese adults with and without PTSD.
Mariko Itoh; Yuri Ujiie; Nobukazu Nagae; Madoka Niwa; Toshiko Kamo; Mingming Lin; Sayuri Hirohata; Yoshiharu Kim
European journal of psychotraumatology, 2017, [Reviewed]
Background: Identifying high-risk groups for posttraumatic stress disorder (PTSD) during evacuation situations requires a valid short screening tool. The re-experiencing symptoms of PTSD are considered helpful for distinguishing those with PTSD from those without, as they are thought to be specific to PTSD, have less ambiguity for respondents, and are representative of all PTSD symptoms. Objective: To develop a new short version of the Posttraumatic Diagnostic Scale (PDS) comprising only re-experiencing symptom items. Method: We used existing data (N = 169) from our previous study on the Japanese version of the PDS and the Clinician-Administered PTSD Scale (CAPS). The sample included both clinical outpatients (n = 106) and university students (n = 63), all of whom reported one or more traumatic experiences. We created candidate 2- and 3-item versions of the PDS and compared their psychometric characteristics against the CAPS. Results: The best candidate (comprising items for 'intrusive images', 'nightmares', and 'physiological reactions when reminded of the trauma') demonstrated an area under the curve of .95, 94.8% sensitivity, 86.1% specificity for the best cut-off score of three. The candidate scale also showed a strong correlation with CAPS-evaluated severity score and internal consistency. Conclusions: The brief re-experiencing PDS had good psychometric properties among Japanese adults with and without PTSD.

Enthusiasm for homework and improvement of psychological distress in subthreshold depression during behavior therapy: Secondary analysis of data from a randomized controlled trial
Hayasaka, Y.; Furukawa, T.A.; Sozu, T.; Imai, H.; Kawakami, N.; Horikoshi, M.; Kadota, M.; Sasaki, M.; Sekiya, Y.; Hosogoshi, H.; Kashimura, M.; Asano, K.; Terashima, H.; Iwasa, K.; Nagasaku, M.; Fukumori, T.; Niwa, M.; Oe, Y.; Shibata, M.; Fujisato, H.; Ito, J.; Hirota, C.; Kawasaki, N.; Shinmei, I.; Takagishi, Y.; Yamada, S.; Hattori, M.; Kitagawa, S.; Nakazawa, K.; Shimada, K.; Shimoda, H.; Tsuchiya, M.; Umeda, M.; Yamagishi, A.; Grothaus, L.C.
BMC Psychiatry, 2015, [Reviewed]

Telephone Cognitive-Behavioral Therapy for Subthreshold Depression and Presenteeism in Workplace: A Randomized Controlled Trial
Toshi A. Furukawa; Masaru Horikoshi; Norito Kawakami; Masayo Kadota; Megumi Sasaki; Yuki Sekiya; Hiroki Hosogoshi; Masami Kashimura; Kenichi Asano; Hitomi Terashima; Kazunori Iwasa; Minoru Nagasaku; Louis C. Grothaus; on behalf of the GENKI Project; Isabelle Boutron
PLoS ONE, Apr. 2012, [Reviewed]

【特集 精神療法・心理療法マニュアル】主な疾患における精神療法 複雑性PTSD　　　　　　　　　　　　　　　
Dec. 2025, [Invited]

【心的外傷およびストレス因関連症群】治療の基本 複雑性PTSDの治療　　　　　　　　　　　　　　　
Nov. 2025, [Invited]

PTSD患者および健常対照者における血清脂質および血漿脂肪酸プロファイル 症状・認知機能・炎症マーカーとの関連　　　　　　　　　　　　　　　
Sep. 2025

【精神科病院における公認心理師の役割】複雑性PTSD心理療法総論/STAIR Narrative Therapy　　　　　　　　　　　　　　　
Aug. 2025, [Invited]

PLASMA LIPID AND FATTY ACID CONCENTRATIONS IN PATIENTS WITH POSTTRAUMATIC STRESS DISORDER (PTSD) AND HEALTHY INDIVIDUALS: ASSOCIATIONS WITH DIAGNOSIS, SYMPTOMS, AND INFLAMMATORY MARKERS
*Shintaro Ogawa; Hiroaki Hori; Madoka Niwa; Mariko Itoh; Mingming Lin; Fuyuko Yoshida; Keiko Ino; Hitomi Kawanishi; Megumi Narita; Wakako Nakano; Risa Imai; Mie Matsui; Toshiko Kamo; Hiroshi Kunugi; Yoshiharu Kim
International Journal of Neuropsychopharmacology, 12 Feb. 2025
Abstract

Background
Posttraumatic stress disorder (PTSD) is a severe psychiatric condition resulting from a traumatic event, affecting both mental and physical health and impairing cognitive function. Lipid- related molecules, such as cholesterol and fatty acids, are crucial in the central nervous system (CNS), and their alterations can influence CNS functions related to PTSD symptoms. However, there is a scarcity of case-control studies examining the connection between plasma lipid-related molecules and PTSD.


Aims & Objectives
We aimed to delve into the link between lipid-related molecules and PTSD, exploring pathophysiology, inter-group variations, and their associations with background factors, psychological functions, PTSD symptoms, and plasma inflammation markers. Additionally, we aimed to assess the potential of lipid-related molecules for subject subtyping and investigate lipid profiles, psychological features, and symptomatic patterns using latent profile analysis (LPA).


Method
We examined 165 participants, comprising 67 PTSD patients and 98 healthy controls without trauma exposure. We assessed PTSD symptoms in patients using the DSM-IV version of the Posttraumatic Diagnostic Scale (PDS-IV). Childhood trauma was gauged through the Childhood Trauma Questionnaire (CTQ), and cognitive function was appraised using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) for all subjects. Venous blood was collected around noon, and plasma samples were analyzed for lipid-related molecules and inflammatory cytokine levels at SRL Inc (Tokyo, Japan). We considered a two-tailed P-value of &lt;0.01 as statistically significant in all analyses, except for LPA, where a significance level of P &lt;0.05 was employed due to its highly exploratory nature.


Results
PTSD patients exhibited significantly lower plasma HDL cholesterol and n-6 linoleic acid levels, as well as higher plasma saturated palmitic acid and Triene/Tetraene (T/T) ratio compared to healthy controls. Hyperarousal symptoms (PDS category D scores) in PTSD patients were significantly positively associated with plasma levels of γ-linolenic (P = 2.5E-5), dihomo-γ-linolenic, mead acids, and the T/T ratio. Plasma γ-linolenic acid levels also showed significant positive correlations with PDS total scores. CTQ scores were significantly negatively correlated with plasma LDL cholesterol levels. Cognitive function, as assessed by RBANS scores, had positive associations with docosahexaenoic acid, n-3 fatty acids, and linoleic acid, but negative associations with dihomo-γ-linolenic, palmitic, and saturated fatty acids. Inflammation-related plasma markers were significantly correlated with plasma oleic (P = 1.9E-5), palmitic, and n-9 fatty acids, while linoleic and polyunsaturated fatty acids displayed opposite correlations. LPA analysis identified variations in plasma lipid and fatty acid profiles, including high linolenic n-6 fatty acids, suitable for subtyping PTSD patients.


Discussion & Conclusion
This study underscores the importance of plasma lipid and fatty acid alterations in PTSD patients, potentially connected to pathophysiology and symptoms, providing a foundation for further research. Additionally, we have identified unique plasma lipid and fatty acid profiles for subtyping patients with PTSD.

【今の時代のトラウマ:診断と評価】ICD-11のPTSDと複雑性PTSDの診断評価のための国際トラウマ面接(International Trauma Interview:ITI)
Feb. 2025, [Invited]

Trauma in the front line: psychological support, treatment and pathological research: Skills training for affective and interpersonal regulation (STAIR)
丹羽まどか
臨床精神医学, Jan. 2025, [Invited]

【小児期逆境体験と精神科臨床】小児期逆境体験とSTAIR Narrative Therapy
Jul. 2024, [Invited]

複雑性PTSDのもたらした臨床的意義 複雑性PTSD診断評価のための国際トラウマ面接(ITI)の日本語版作成過程
Jun. 2024

ストレスへの気づきとセルフケア
2024, [Invited]

Cognitive behavioral therapy for complex PTSD.
丹羽まどか; 金吉晴
臨床精神薬理, Jan. 2024, [Invited]

STAIR Narrative Therapy for Complex PTSD
丹羽まどか
精神医学, Aug. 2023, [Invited]

児童期虐待に関連した複雑性PTSDに対するSTAIR Narrative Therapyの前後比較試験の成果　　　　　　　　　　　　　　　
Jul. 2023

成人期のPTSDと小児期の虐待歴における視床下部-下垂体-副腎系とレニン-アンジオテンシン-アルドステロン系(Hypothalamic-pituitary-adrenal axis and renin-angiotensin-aldosterone system in adulthood PTSD and childhood maltreatment history)　　　　　　　　　　　　　　　
Jul. 2023

【複雑性PTSD臨床における「勘所」】STAIR Narrative Therapy実践の勘所
Jun. 2023, [Invited]

［Review of Books Abroad］ Denise M. Sloan & Brian P. Marx : Written Exposure Therapy for PTSD : A brief treatment approach for mental health professionals　　　　　　　　　　　　　　　
Feb. 2023, [Invited]

STAIR Narrative Therapyの複雑性PTSDへの適用と工夫
2023

心的外傷後ストレス障害(PTSD)に対するメマンチンの有効性および安全性を評価する無作為化二重盲検プラセボ対照比較試験:研究プロトコール
2023

PTSD女性患者における自殺リスク 幼少期被虐待体験、炎症マーカー、炎症系遺伝子多型との関連
Jun. 2022

【心的外傷およびストレス因関連障害 レジデントが知っておきたい診断や治療のコツ!】PTSDと類縁疾患 複雑性PTSD
May 2022, [Invited]

複雑性PTSDの理解と治療支援 複雑性PTSDに対するSTAIR Narrative Therapyの有効性の検討　　　　　　　　　　　　　　　
Apr. 2022

複雑性PTSDの診断と特徴,および治療
2022, [Invited]

Group Skills Training in Affective and Interpersonal Regulation (STAIR) for Complex PTSD
丹羽まどか; 丹羽まどか; 金吉晴
精神療法, Oct. 2021, [Invited]

The International Trauma Interview/Questionnaire for ICD-11 complex PTSD
丹羽まどか; 丹羽まどか; KIM Yoshiharu
精神療法, Aug. 2021, [Invited]

心的外傷後ストレス障害の評価指標としての認知バイアスの検討
Mar. 2021

炎症と記憶に着目したPTSDの遺伝学的検討
2021

心的外傷後ストレス障害の評価指標としての認知バイアスの検討
Mar. 2020

心的外傷後ストレス障害の女性患者における炎症マーカー
2020

ストレス関連疾患の疾患横断的なバイオマーカー検索のための脳MRI研究
Dec. 2019

複雑性PTSD(Complex PTSD)とは
Jun. 2019, [Invited]

Psychopathology and Treatment of Complex PTSD : From the standpoint of cognitive behavioral therapy, STAIR/NST
Jun. 2019, [Invited]

Clinician administered version of Snaith-Hamilton Pleasure Scale(SHAPS-C)日本語版の作成(第一報)　　　　　　　　　　　　　　　
Oct. 2018

Complex PTSD : Concept and Treatment
Jun. 2018

【複雑性PTSDの理論と治療】性的虐待による複雑性PTSD患者に対するSTAIR/NST
Jun. 2018

PTSD女性患者における認知機能
Mar. 2018

性的虐待といじめによる複雑性PTSD症例に対するSTAIR/NSTの実践
2018

複雑性PTSDの診断評価について
2018

心的外傷後ストレス障害を有する日本人女性における認知機能:運動習慣との関連
2018

PTSD診断・評価のためのPosttraumatic Diagnostic Scale日本語版および短縮版尺度の開発
2018

PTSD女性患者における炎症マーカー：炎症の亢進が認知機能低下に影響を与える可能性　　　　　　　　　　　　　　　
2018

PTSD女性患者における認知機能
Oct. 2017

PTSD女性患者における炎症マーカー(Inflammatory markers in adult women with posttraumatic stress disorder)　　　　　　　　　　　　　　　
堀 弘明; 伊藤 真利子; 林 明明; 丹羽 まどか; 井野 敬子; 今井 理紗; 小川 成; 関口 敦; 功刀 浩; 加茂 登志子; 金 吉晴
日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集, Sep. 2017
日本生物学的精神医学会・日本神経精神薬理学会

The relationship between childhood trauma and attention/memory biases among healthy adult women
Itoh Mariko; Lin Mingming; Niwa Madoka; Hori Hiroaki; Kim Yoshiharu
The Proceedings of the Annual Convention of the Japanese Psychological Association, Aug. 2017
The Japanese Psychological Association

ストレス関連疾患の診断横断的なバイオマーカー検索のための脳MRI研究　　　　　　　　　　　　　　　
2017

健常成人における主観的不安と認知・生物学的指標の関連 PTSDの客観的診断指標開発に向けて
Oct. 2016

PTSDスクリーニングのための自記式尺度の開発:日本語版Posttraumatic Diagnostic Scaleの再体験3項目版尺度
2016

The Efficacy of Parent-Child Interaction Therapy for Japanese Mother-Child Dyads Exposed to Intimate Partner Violence
Toshiko KAMO; Yuri UJIIE; Fumie ITO; Michi NAKAYAMA; Madoka ITO; Yoshiharu KIM
Jan. 2016

性暴力被害者の精神科臨床 一般精神科臨床現場で、性暴力被害者への治療をどのように組み立てるか パートナー間暴力被害に潜む性暴力のインパクト　　　　　　　　　　　　　　　
加茂 登志子; 三上 由里; 本田 朋子; 横田 仁子; 伊藤 まどか; 中山 未知; 伊東 史ヱ; 金 吉晴
精神神経学雑誌, Jun. 2015
(公社)日本精神神経学会

DVを受けた母親の精神症状と子どもの回復について―前向き縦断研究と国内外の知見から
2015

書評『子どものトラウマと悲嘆の治療－トラウマ・フォーカスト認知行動療法マニュアル』　　　　　　　　　　　　　　　
2015

大規模災害や犯罪被害者等による精神疾患の実態把握と対応ガイドラインの作成・評価に関する研究 唾液コルチゾール測定によるPTSD症状評価の利点と注意点:DV被害母子研究に向けて
2014

大規模災害や犯罪被害者等による精神疾患の実態把握と対応ガイドラインの作成・評価に関する研究 DV被害親子に対するこころのケアハンドブックの開発に関する研究-その2 専門的治療に関する専門職トレーニングのストラテジーについて
2014

日本語版PTSD診断尺度（PDS）の妥当性－臨床群における検討
2014

大規模災害や犯罪被害等による精神疾患の実態把握と対応ガイドラインの作成・評価に関する研究 DV被害親子に対するこころのケアガイドラインの開発に関する研究
2013

DV被害を受けた母子へのフォローアップ研究
2013

医療現場におけるChild-Adult Relationship Enhancement (CARE)の実践報告 : ドメスティック・バイオレンス被害を受けた母親に対するCAREを用いたグループ療法型子育て支援の試み
2013

大規模災害や犯罪被害等による精神疾患の実態把握と対応ガイドラインの作成・評価に関する研究 DV被害母子に対する親子相互交流療法(Parent-Child Interaction Therapy:PCIT)の効果に関する研究-DV被害母子フォローアップ研究との比較
2012

マルトリートメント事例へのPCIT施行—極低出生体重の一卵性双生児とその母—　　　　　　　　　　　　　　　
2012

DV被害女性の精神健康障害の経過―DV被害を受けた母子の精神健康障害に関する１年間の前向きフォローアップ調査から
2012

大規模災害や犯罪被害等による精神科疾患の実態把握と介入手法の開発に関する研究 DV被害を受けた母子へのフォローアップ研究-1年後の精神的健康・行動・生活と母子相互作用の変化に関する検討-
2011

大規模災害や犯罪被害等による精神科疾患の実態把握と介入方法の開発に関する研究 心的外傷後ストレス障害に対する持続エクスポージャー療法の無作為比較試験
2011

大規模災害や犯罪被害等による精神科疾患の実態把握と介入手法の開発に関する研究 DV被害を受けた母子へのフォローアップ研究-1年後の精神的健康・行動・生活と母子相互作用の変化に関する検討-
2010

大規模災害や犯罪被害等による精神科疾患の実態把握と介入方法の開発に関する研究 心的外傷後ストレス障害に対する持続エクスポージャー療法の無作為比較試験
2010

東京女子医科大学における親子相互交流療法（PCIT）の臨床実践
2010

クリニックにおける多職種での治療アプローチが有効であった思春期青年期ケースの特徴
Sep. 2009

大規模災害や犯罪被害等による精神科疾患の実態把握と介入手法の開発に関する研究 DV被害を受けた母子へのフォローアップ研究-1年後の精神的健康・行動・生活と母子相互作用の変化に関する検討-
2009

認知処理療法の実際と日本への導入について　　　　　　　　　　　　　　　
2009

暴力・転換・強迫症状等が認められた中学3年不登校女子の治療過程 クリニックにおける多職種での治療アプローチ(第2報)
Nov. 2008

犯罪被害者の精神健康の状況とその回復に関する研究「臨床心理士における犯罪被害者およびその家族の相談に関する調査」
2008

犯罪被害者の精神健康の状況とその回復に関する研究 犯罪被害者のPTSD治療「PTSDに特化した心理療法:認知処理療法」
2008

犯罪被害者の精神健康の状況とその回復に関する研究 メンタルヘルス領域における犯罪被害者の相談,治療,連携の現状について「臨床心理士における犯罪被害者およびその家族の相談に関する調査」
2008

犯罪被害者の精神健康の状況とその回復に関する研究 犯罪被害者の重度ストレス反応の治療について「PTSDに特化した心理療法:認知処理療法」
2008

臨床心理士における犯罪被害者相談受理の実態　　　　　　　　　　　　　　　
2008

不定性感情体験尺度の作成　　　　　　　　　　　　　　　
2007

不定性感情（もやもや感）の主観的体験過程の検討　　　　　　　　　　　　　　　
2006

感情認識力が不快感情の制御プロセスに及ぼす影響
2005

複雑性PTSDの臨床　　　　　　　　　　　　　　　
Contributor
Mar. 2021

Treating Survivors of Childhood Abuse: Psychotherapy for the Interrupted Life　　　　　　　　　　　　　　　
Joint translation, Marylene Cloitre; Lisa R. Cohen; Karestan C. Koenen
May 2020

心理臨床学事典
Contributor
2011
9784621084083

福島原発事故被災者に認められる複雑性PTSDの可能性と心理・社会・経済的要因―2025年度NHK・早稲田共同調査から　　　　　　　　　　　　　　　
25 Jul. 2026

DERS日本語版の開発と信頼性・妥当性の検討―トラウマ体験がある人を対象として　　　　　　　　　　　　　　　
25 Jul. 2026

精研版CAPS-5の信頼性・妥当性の検証と生成AIの利用可能性についての検討　　　　　　　　　　　　　　　
25 Jul. 2026

Effects of STAIR Narrative Therapy on cognitive functions: analysis of a pilot study for ICD-11 complex PTSD　　　　　　　　　　　　　　　
Madoka Niwa; Tomoko Kato; Yosuke Suga; Rieko Otomo; Mayumi Sugawara; Yoshiharu Kim
International Society for Traumatic Stress Studies 40th Annual Meeting, 26 Sep. 2024

複雑性PTSD診断評価のための国際トラウマ面接（ITI）の日本語版作成過程（シンポジウム：複雑性PTSDがもたらした臨床的意義）　　　　　　　　　　　　　　　
22 Jun. 2024

STAIR Narrative Therapyの複雑性PTSDへの適用と工夫（シンポジウム：複雑性PTSDに対するトラウマ焦点化治療の適用と工夫）　　　　　　　　　　　　　　　
06 Aug. 2023

複雑性PTSDとSTAIR Narrative Therapy　　　　　　　　　　　　　　　
23 Feb. 2023

複雑性PTSDに対するSTAIR Narrative Therapyの有効性の検討　　　　　　　　　　　　　　　
17 Jun. 2022

STAIR Narrative Therapyの症例提示　　　　　　　　　　　　　　　
10 Dec. 2021

Narrative Therapyの治療内容①②　　　　　　　　　　　　　　　
03 Dec. 2021

STAIR段階の治療内容ー対人関係①②　　　　　　　　　　　　　　　
03 Dec. 2021

治療全体の振り返り　　　　　　　　　　　　　　　
17 Jan. 2020

Narrative Therapyの治療内容①②　　　　　　　　　　　　　　　
17 Jan. 2020

症例提示　　　　　　　　　　　　　　　
17 Jan. 2020

STAIR段階の治療内容ー対人関係①②　　　　　　　　　　　　　　　
16 Jan. 2020

A preliminary evaluation of the feasibility and utility of combined intervention of positive-valence system focused cognitive behavior therapy and inaudible high-frequency sound presentation for anhedonia　　　　　　　　　　　　　　　
Mitsuhiro Miyamae; Masaya Ito; Yuichi Yamashita; Chika Yokoyama; Asami Komazawa; Osamu Ueno; Madoka Niwa; Manabu Honda; Masaru Horikoshi
ADAA 39th Annual Conference, 2019

複雑性PTSDの診断評価について　　　　　　　　　　　　　　　
Jun. 2018

性的虐待といじめによる複雑性PTSD症例に対するSTAIR/NSTの実践　　　　　　　　　　　　　　　
Jun. 2018

PTSD女性患者における炎症マーカー：炎症の亢進が認知機能低下に影響を与える可能性　　　　　　　　　　　　　　　
2018

The relationship between childhood trauma and attention/memory biases among healthy adult women
Itoh Mariko; Lin Mingming; Niwa Madoka; Hori Hiroaki; Kim Yoshiharu
The Proceedings of the Annual Convention of the Japanese Psychological Association, 2017, The Japanese Psychological Association

ストレス関連疾患の診断横断的なバイオマーカー検索のための脳MRI研究　　　　　　　　　　　　　　　
2017

Inflammatory markers in adult women with posttraumatic stress disorder　　　　　　　　　　　　　　　
Hiroaki Hori; Mariko Itoh; Mingming Lin; Madoka Niwa; Keiko Ino; Risa Imai; Sei Ogawa; Atsushi Sekiguchi; Hiroshi Kunugi; Toshiko Kamo; Yoshiharu Kim
13th World Congress of Biological Psychiatry, 2017

The trajectory of mental health among mothers and children who exposed to intimate partner violence: prospective longitudinal study　　　　　　　　　　　　　　　
Madoka Ito; Toshiko Kamo; Yuri Ujiie; Michi Nakayama; Yoshiharu Kim
nternational Society for Traumatic Stress Studies 32th Annual Meeting, 2016

パートナー間暴力被害に潜む性暴力のインパクト　　　　　　　　　　　　　　　
Jun. 2015

DVを受けた母親の精神症状と子どもの回復について―前向き縦断研究と国内外の知見から　　　　　　　　　　　　　　　
Jun. 2015

日本語版PTSD診断尺度（PDS）の妥当性－臨床群における検討　　　　　　　　　　　　　　　
2014

Mother’s dissociation with victims of intimate partner violence has negative relationships on child’s cognitive functioning: A prospective longitudinal study　　　　　　　　　　　　　　　
Madoka Ito; Toshiko Kamo; Yuri Ujiie; Michi Nakayama; Naohiro Yonemoto; Yoshiharu Kim
International Society for Traumatic Stress Studies 30th Annual Meeting, 2014

DV被害を受けた母子へのフォローアップ研究　　　　　　　　　　　　　　　
May 2013

DV被害女性の精神健康障害の経過―DV被害を受けた母子の精神健康障害に関する１年間の前向きフォローアップ調査から　　　　　　　　　　　　　　　
Jun. 2012

Prospective study of female victims of domestic violence and their children: The relationship between the mental health of the mother and the child　　　　　　　　　　　　　　　
Madoka Ito; Toshiko Kamo; Yuri Ujiie; Michi Nakayama; Fumie Ito; Yoshiharu Kim
International Society for Traumatic Stress Studies 27th Annual Meeting, 2011

東京女子医科大学における親子相互交流療法（PCIT）の臨床実践　　　　　　　　　　　　　　　
Mar. 2010

The preliminary evaluation of efficacy of Parent-Child Interaction Therapy for Japanese mother and child victimized by domestic violence　　　　　　　　　　　　　　　
Toshiko Kamo; Fumie Ito; Madoka Niwa; Tami Yanagita; Yoshiharu Kim
20th International Federation for Psychotherapy World Congress of Psychotherapy, 2010

女性外来におけるトラウマとトラウマ関連疾患－性差に配慮したトラウマ関連疾患の診断と治療－　　　　　　　　　　　　　　　
Mar. 2009

認知処理療法の実際と日本への導入について　　　　　　　　　　　　　　　
Mar. 2009

臨床心理士における犯罪被害者相談受理の実態　　　　　　　　　　　　　　　
2008

不定性感情体験尺度の作成　　　　　　　　　　　　　　　
2007

不定性感情（もやもや感）の主観的体験過程の検討　　　　　　　　　　　　　　　
2006

Effect of ability to recognize emotions on control process of unpleasant emotions　　　　　　　　　　　　　　　
Madoka Niwa; Naoki Kawasaki; Masahiro Kodama
International Congress of Psychotherapy in Japan and the Third International Conference of the Asian Federation for Psychotherapy, 2006

感情認識力が不快感情の制御プロセスに及ぼす影響　　　　　　　　　　　　　　　
2005

複雑性PTSDに対する心理療法の有効性検証と診断治療体制整備に資する研究
Apr. 2026 - Mar. 2030

Development of the Trauma-Informed Compassion-Focused Therapy for Depression and Anxiety
Grant-in-Aid for Scientific Research (B)
University of Tsukuba
Apr. 2024 - Mar. 2029

Validation of the Japanese version of the International Trauma Interview and International Trauma Questionnaire
Grant-in-Aid for Early-Career Scientists
National Center of Neurology and Psychiatry
Apr. 2022 - Mar. 2027

複雑性心的外傷後ストレス症に対する心理療法（STAIR Narrative Therapy）の 無作為化比較試験　　　　　　　　　　　　　　　
Apr. 2025 - Mar. 2026

Examination of Intervention for Complex Posttraumatic Stress Disorder
Grant-in-Aid for JSPS Fellows
National Center of Neurology and Psychiatry
Jul. 2019 - Mar. 2022

Examination of the effectiveness of cognitive behavioral therapy for complex PTSD
Grant-in-Aid for Challenging Exploratory Research
National Center of Neurology and Psychiatry
Feb. 2017 - Mar. 2020
The purpose of this study was to examine the feasibility, safety, and effectiveness of STAIR/NST (Skills Training in Affective and Interpersonal Regulation followed by Narrative Story Telling) for complex PTSD in Japan. This study was a single-arm trial. Eight patients with complex PTSD were enrolled, treated with STAIR/NST, and followed up. Case reports on the treatment process were presented at a conference and published in an academic journal.
We have also developed a Japanese version of the STAIR/NST manual, materials, and diagnostic assessment tools for complex PTSD. Specifically, we translated the International Trauma Interview (ITI) for ICD-11 PTSD and Complex PTSD. The full text of the Japanese version of the International Trauma Questionnaire (ITQ) was published in an academic journal.

Research using cognitive tasks to find objective evaluation index of PTSD
Grant-in-Aid for Challenging Exploratory Research
National Center of Neurology and Psychiatry
Apr. 2016 - Mar. 2018
Healthy individuals including those with childhood trauma experience and patients with posttraumatic stress disorder (PTSD) performed cognitive tasks to measure the attention and memory bias toward negative information. Negative memory bias tended to be related to childhood trauma scores, diagnosis of PTSD, and severity of PTSD, suggesting that negative memory bias could be useful as an objective evaluation index of trauma experience or PTSD.