Takashi Mizuma
| Faculty of Pharmaceutical Sciences,Department of Pharmaceutical Sciences | Professor |
Last Updated :2025/10/07
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Paper
- Kinetic Assessment of Luminal Degradation of Orally Effective Prodrugs for Rational Drug Development
Takashi Mizuma
JOURNAL OF PHARMACEUTICAL SCIENCES, Feb. 2010, [Reviewed] - Intestinal glucuronidation metabolism may have a greater impact on oral bioavailability than hepatic glucuronidation metabolism in humans: A study with raloxifene, substrate for UGT1A1, 1A8, 1A9, and 1A10
Takashi Mizuma
INTERNATIONAL JOURNAL OF PHARMACEUTICS, Aug. 2009, [Reviewed] - Assessment of Presystemic and Systemic Intestinal Availability of Orally Administered Drugs Using In Vitro and In Vivo Data in Humans: Intestinal Sulfation Metabolism Impacts Presystemic Availability Much More Than Systemic Availability of Salbutamol, SULT1A3 Substrate
Takashi Mizuma
JOURNAL OF PHARMACEUTICAL SCIENCES, Dec. 2008, [Reviewed] - Drug delivery system utilizing sugar transporter
MIZUMA Takashi
Drug Delivery System, 10 Mar. 2006
This review summarizes studies on drug delivery system (DDS) utilizing sugar transporter. It has been reported intestinal absorption of various monosaccharide conjugates (glycosides) via Na+/glucose cotransporter (SGLT1). Transportability and recognizability of the glycosides by SGLT1 depend on types of sugar, glycoside linkage and aglycone. Therefore, glycosides should be classified by TRN classification for DDS development. Transportability of β-glucoside is the highest among glycosides. Monosaccharide conjugates such as β-glucoside should work as a prodrug, which can be transported by SGLT1. Moreover, disaccharide conjugates have potential as a pre-prodrug.
On the other hand, it has not been reported clear evidence for sugar transporter-mediated delivery of glycosides to brain and kidney. - Kinetic characterization of glycosidase activity from disaccharide conjugate to monosaccharide conjugate in Caco-2 cells.
Mizuma T; Fuseda N; Hayashi M
The Journal of pharmacy and pharmacology, May 2005, [Reviewed] - Differentiation of organ availability by sequential and simultaneous analyses: intestinal conjugative metabolism impacts on intestinal availability in humans.
Mizuma T; Kawashima K; Sakai S; Sakaguchi S; Hayashi M
Journal of pharmaceutical sciences, Mar. 2005, [Reviewed] - Simultaneous HPLC assay of lenampicillin (ampicillin prodrug), ampicillin, and marker compound for high-throughput in vitro assessment of intestinal absorption and metabolism using caco-2 cells
T Mizuma; S Sakaguchi; M Hayashi
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 2005, [Reviewed] - SGLT1-mediated transport of glucoside increase intestinal availability
Y Nakajima; M Nakamura; T Mizuma; H Ina; T Miyazaki; M Hayashi
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2004, [Reviewed] - Concentration-dependent atypical intestinal absorption of cyclic phenylalanylserine: Small intestine acts as an interface between the body and ingested compounds
T Mizuma; T Narasaka; S Awazu
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Nov. 2003, [Reviewed] - Uptake of cyclic dipeptide by PEPT1 in Caco-2 cells: phenolic hydroxyl group of substrate enhances affinity for PEPT1
T Mizuma; T Narasaka; S Awazu
JOURNAL OF PHARMACY AND PHARMACOLOGY, Sep. 2002, [Reviewed] - Role of Transporter and Metabolic Enzyme in Sequential and Competitive Process of Intestinal Absorption: Study on SGLT1, Disaccharidase and Peptidases.
MIZUMA Takashi; MATSUMOTO Seiichi; HAGI Katsura; KOYANAGI Akihiro; NARASAKA Takuo; FUSEDA Norihiko; HAYASHI Masahiro; AWAZU Shoji
Drug Metabolism and Pharmacokinetics, 2001
We have studied intestinal metabolism and transport, which is considered to be sequential (1) or competitive (2) process in absorption (Scheme 1). (1) Disaccharide (maltose, cellobiose, lactose) conjugates of p-nitrophenol were hydrolyzed to p-nitrophenyl β-glucosides (p-NPβglc) on the mucosal side. p-NPβglc was transported by Na+/glucose cotransporter (SGLT1). Transport clearance of p-NPβglc formed from cellobiose and lactose conjugates of p-NP were higher than that from maltose or of p-NPβglc itself. These results suggest that SGLT1 is cooperatively coupled with lactase/phloridzin hydrolase catalyzing hydrolysis of cellobiose and lactose conjugates. There might be cooperative relationship between peptidase and H+/oligopeptide cotransporter or amino acid transporter as well. (2) Kyotorphin (KTP) was too unstable in intestine to be absorbed. KTP appeared on the serosal side in the presence of peptidase inhibitors. Meanwhile, cyclic KTP was stable in intestine to be absorbed. Absorption clearance of cyclic KTP was higher than the overall transport clearance of KTP, which was calculated according to the metabolic inhibition model. Competitive process was observed in intestinal absorption of α-naphthol as well. These results indicate that metabolism degradation and membrane transport are competitive. Unless drug is stabilized against metabolic enzyme, intestinal absorption of drug can not be improved even if membrane transport is increased. - ROLE OF TRANSPORTER AND METAOBLIC ENZYME IN INTESTINAL DRUG ABSORPTION
MIZUMA Takashi; MATSUMOTO Seiichi; HAGI Katsura; KOYANAGI Akihiro; NARASAKA Takuo; FUSEDA Norihiko; HAYASHI Masahiro; AWAZU Shoji
Drug Metabolism and Pharmacokinetics, 2000
We have studied intestinal metabolism and transport, which is considered as sequential (1) or competitive (2) process in absorption (Scheme 1). (1) Disaccharide (maltose, cellobiose, lactose) conjugates of p-nitrophenol were hydrolyzed to p-nitrophenyl β-glucosides (p-NPβglc) on the mucosal side. p-NPβglc was transported by Na+/glucose cotransporter (SGLT1). Transport clearance of p-NPβglc formed from cellobiose and lactose conjugates of p-NP were higher than that from maltose or of p-NPβglc itself. These results suggest that SGLT1 may be cooperatively coupled with lactase/phloridzin hydrolase catalizing hydrolysis of cellobiose and lactose conjugates. There might be cooperative relationship between peptidase and H+/oligopeptide cotransporter or amino acid transporter as well. (2) Kyotorphin (KTP) was too unstable in intestine to be absorbed. KTP appeared on the serosal side in the presence of peptidase inhibitors. Meanwhile, cyclic KTP was stable in intestine to be absorbed. Absorption clearance of cyclic KTP was higher than the overall transport clearance of KTP, which was calculated according to the metabolic inhibition model. These results indicate that metabolism degradation and membrane transport are competitive. Unless drug is stabilized against metabolic enzyme, intestinal absorption of drug can not be improved even if membrane transport is increased. - Transportability and recognizability of SGLT1 for alkyl glucosides: TRN (Transportable, Recognizable, Non-interactive) classification of glucose conjugates
T Mizuma; S Matsumoto; S Awazu
CONTROL AND DISEASES OF SODIUM DEPENDENT TRANSPORT PROTEINS AND ION CHANNELS, 2000, [Reviewed] - Intestinal absorption of acyclovir beta-glucoside: Comparative study with acyclovir, guanosine, and kinetin beta-glucoside
T Mizuma; S Masubuchi; S Awazu
PHARMACEUTICAL RESEARCH, Jan. 1999, [Reviewed] - Intestinal absorption and analgesic activity of aminopeptidase-resistant cellobiose-coupled leucine enkephalinamide
T Mizuma; K Ohta; S Awazu
BIOPHARMACEUTICS & DRUG DISPOSITION, Dec. 1998, [Reviewed] - Intestinal Na+/glucose cotransporter-mediated transport of glucose conjugate formed from disaccharide conjugate
T Mizuma; S Awazu
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, Jan. 1998, [Reviewed] - ACTION MECHANISM OF PERMEATION ENHANCERS IN PARACELLULAR PATHWAY
M HAYASHI; M CHIDA; T OGAWA; T MIZUMA; T HORIE; S AWAZU
JOURNAL OF PHARMACOBIO-DYNAMICS, Feb. 1992, [Reviewed]
MISC
- Intestinal SGLT1-mediated absorption and metabolism of benzyl beta-glucoside contained in Prunus mume: carrier-mediated transport increases intestinal availability
T Mizuma; M Nakamura; H Ina; T Miyazaki; M Hayashi
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, Mar. 2005 - Dietary polyphenols (-)-epicatechin and chrysin inhibit intestinal glucuronidation metabolism to increase drug absorption
T Mizuma; S Awazu
JOURNAL OF PHARMACEUTICAL SCIENCES, Sep. 2004 - In vitro assessment of conjugative metabolism and absorption by using Caco-2 cells: Detection of drug-drug/nutrient interactions
T Mizuma; H Kawashima; M Tanaka; M Hayashi
DRUG METABOLISM REVIEWS, Aug. 2004 - 糖付加体の吸収動態と体内分布 : 梅肉含有 Benzylglucoside について
05 Mar. 2003 - Caco-2細胞を用いたグルクロン酸抱合代謝活性評価及び代謝阻害効果の検討
05 Mar. 2003 - Metabolism and membrane transport of alpha-naphthol in Caco-2 cells: Cell monolayers and suspensions
T Mizuma; H Kawashima; M Hayashi
DRUG METABOLISM REVIEWS, 2003 - Kinetic Impact of Presystemic Intestinal Metabolism on Drug Absorption: Experiment and Data Analysis for the Prediction of In Vivo Absorption from In Vitro Data
Takashi Mizuma
Drug Metabolism and Pharmacokinetics, 2002 - Caco-2細胞におけるグルクロン酸抱合代謝活性の変動とその要因
17 Sep. 2001 - Caco-2細胞におけるグルクロン酸抱合代謝の各種要因の検討
05 Mar. 2001 - Intestinal transport and metabolism of glucose-conjugated kyotorphin and cyclic kyotorphin: metabolic degradation is crucial to intestinal absorption of peptide drugs
T Mizuma; A Koyanagi; S Awazu
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, Jun. 2000 - Intestinal transport of beta-thioglycosides by Na+/glucose cotransporter
T Mizuma; K Hagi; S Awazu
JOURNAL OF PHARMACY AND PHARMACOLOGY, Mar. 2000 - Transport and recognition of aminopeptidase-resistant cellobiose-coupled tyrosylglycylglycine by intestinal Na+/glucose cotransporter (SGLT1): Recognition of sugar conjugates by SGLT1 is much less restricted than transport
T Mizuma; N Sakai; K Hagi; S Awazu
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Aug. 1999 - Photoinduced covalent binding of frusemide and frusemide glucuronide to human serum albumin
T Mizuma; AF McDonagh; ET Lin; LZ Benet
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, Jul. 1999 - Photoinduced covalent binding of frusemide and frusemide glucuronide to human serum albumin
T Mizuma; AF McDonagh; ET Lin; LZ Benet
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, Jul. 1999 - Interaction of human serum albumin with furosemide glucuronide: a role of albumin in isomerization, hydrolysis, reversible binding and irreversible binding of a 1-O-acyl glucuronide metabolite
T Mizuma; LZ Benet; ET Lin
BIOPHARMACEUTICS & DRUG DISPOSITION, Apr. 1999 - Inhibitory effect of phloridzin and phloretin on glucuronidation of p-nitrophenol, acetaminophen and 1-naphthol: kinetic demonstration of the influence of glucuronidation metabolism on intestinal absorption in rats
T Mizuma; S Awazu
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, Oct. 1998 - Factors that cause the beta-anomeric preference of Na+/glucose cotransporter for intestinal transport of monosaccharide conjugates
T Mizuma; Y Nagamine; A Dobashi; S Awazu
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, Aug. 1998 - Factors that cause the beta-anomeric preference of Na+/glucose cotransporter for intestinal transport of monosaccharide conjugates
T Mizuma; Y Nagamine; A Dobashi; S Awazu
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, Aug. 1998 - Intestinal metabolism and transport of alpha-disaccharide conjugates: The role of disaccharidase in the Na+/glucose cotransporter-mediated transport
T Mizuma; S Awazu
RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY, Apr. 1998 - Transport mechanisms of a glycoside, p-nitrophenyl-beta-D-glucopyranoside, across rat small intestinal brush-border membranes
T Ohnishi; S Higashi; T Mizuma; S Awazu
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Mar. 1998 - Intestinal absorption of stable cyclic dipeptides by the oligopeptide transporter in rat
T Mizuma; S Masubuchi; S Awazu
JOURNAL OF PHARMACY AND PHARMACOLOGY, Feb. 1998 - The metabolic inhibition model which predicts the intestinal absorbability and metabolizability of drug: Theory and experiment
Takashi Mizuma; Shoji Awazu
Biological Procedures Online, 1998
University of Western Ontario - Preparative chromatography of furosemide 1-O-acyl-glucuronide from urine using micronized Amberiite XAD-2 and its application to other 1-O-acyl-glucuronides
T Mizuma; LZ Benet; ET Lin
PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY, 1998 - Intestinal Na+/glucose cotransporter-mediated transport of glucose conjugate formed from disaccharide conjugate
Biochim. Biophys. Acta. ,, 1998 - Cellulase-catalyzed transglucosylation of acetaminophen and acyclovir: Preparative enzymatic synthesis of beta-glucose conjugate
T Mizuma; S Masubuchi; S Awazu
PHARMACEUTICAL RESEARCH, Nov. 1997 - Intestinal absorption of stable cyclic glycylphenylalanine: Comparison with the linear form
T Mizuma; S Masubuchi; S Awazu
JOURNAL OF PHARMACY AND PHARMACOLOGY, Nov. 1997 - Preference of Peyer's patches to jejunal epithelium for intestinal absorption of oligopeptides, tyrosylglycylglycine and D-kyotorphin
S Haseto; T Mizuma; H Ouchi; T Isoda; M Hayashi; S Awazu
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Sep. 1997 - Hepatic uptake of p-nitrophenyl sulfate by transporter that acetaminophen sulfate shares for uptake: Sulfate moiety as a vector for metabolite transport
N SakumaSawada; S Iida; T Mizuma; M Hayashi; S Awazu
RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY, Aug. 1997 - Inhibition of the hepatic uptake of paracetamol sulphate by anionic compounds
N SakumaSawada; S Iida; T Mizuma; M Hayashi; S Awazu
JOURNAL OF PHARMACY AND PHARMACOLOGY, Aug. 1997 - Intestinal absorption of lactonolactone-coupled tripeptide and stability in serum: Effect of linkage between peptide and monosaccharide moiety
T Mizuma; K Ohta; S Awazu
PROTEIN AND PEPTIDE LETTERS, Apr. 1997 - Intestinal transport and metabolism of analgesic dipeptide, kyotorphin: Rate-limiting factor in intestinal absorption of peptide as drug
T Mizuma; A Koyanagi; S Awazu
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, Apr. 1997 - Peripherally active analgesia of aminopeptidase-resistant sugar-coupled leucine enkephalin
T Mizuma; K Ohta; S Awazu
RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY, Jan. 1997 - Improvement of intestinal absorption of leucine enkephalin by sugar coupling and peptidase inhibitors
T Mizuma; K Ohta; A Koyanagi; S Awazu
JOURNAL OF PHARMACEUTICAL SCIENCES, Aug. 1996 - Intestinal absorption and analgesic activity of sugar-coupled leucine enkephalinamide
T Mizuma; K Ohta; S Awazu
23RD INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS, 1996 PROCEEDINGS, 1996 - NA+-DEPENDENT TRANSPORT OF AMINOPEPTIDASE-RESISTANT SUGAR-COUPLED TRIPEPTIDES NV RAT INTESTINE
T MIZUMA; N SAKAI; S AWAZU
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 1994 - THE BETA-ANOMERIC AND GLUCOSE PREFERENCES OF GLUCOSE-TRANSPORT CARRIER FOR INTESTINAL ACTIVE ABSORPTION OF MONOSACCHARIDE CONJUGATES
T MIZUMA; K OHTA; S AWAZU
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, Jul. 1994 - TRANSPORT OF LOW AND HIGH-MOLECULAR PEPTIDES ACROSS RABBIT PEYERS-PATCHES
S HASETO; H OUCHI; T ISODA; T MIZUMA; M HAYASHI; S AWAZU
PHARMACEUTICAL RESEARCH, Mar. 1994 - COMPARATIVE-STUDY OF ACTIVE ABSORPTION BY THE INTESTINE AND DISPOSITION OF ANOMERS OF SUGAR-CONJUGATED COMPOUNDS
T MIZUMA; K OHTA; M HAYASHI; S AWAZU
BIOCHEMICAL PHARMACOLOGY, Apr. 1993 - PREDICTABILITY OF THE COVALENT BINDING OF ACIDIC DRUGS IN MAN
LZ BENET; H SPAHNLANGGUTH; S IWAKAWA; C VOLLAND; T MIZUMA; S MAYER; E MUTSCHLER; ET LIN
LIFE SCIENCES, 1993 - IMPROVEMENT OF POORLY ABSORBABLE DRUG BY INTESTINAL GLUCOSE-TRANSPORT SYSTEM
T MIZUMA; K OHTA; M HAYASHI; S AWAZU
JOURNAL OF PHARMACOBIO-DYNAMICS, Jul. 1992 - SPECIES AND ORGAN DIFFERENCES OF SULFATE CONJUGATION OF PARA-NITROPHENOL IN LIVER AND PLATELETS
J NAKAMURA; T MIZUMA; M HAYASHI; S AWAZU
CHEMICAL & PHARMACEUTICAL BULLETIN, Jul. 1992 - INTESTINAL ACTIVE ABSORPTION OF SUGAR-CONJUGATED COMPOUNDS BY GLUCOSE-TRANSPORT SYSTEM - IMPLICATION OF IMPROVEMENT OF POORLY ABSORBABLE DRUGS
T MIZUMA; K OHTA; M HAYASHI; S AWAZU
BIOCHEMICAL PHARMACOLOGY, May 1992 - INTESTINAL ACTIVE ABSORPTION OF SUGAR-CONJUGATED COMPOUNDS BY GLUCOSE-TRANSPORT SYSTEM - IMPLICATION OF IMPROVEMENT OF POORLY ABSORBABLE DRUGS
T MIZUMA; K OHTA; M HAYASHI; S AWAZU
BIOCHEMICAL PHARMACOLOGY, May 1992 - SULFATE CONJUGATION ENHANCES REVERSIBLE BINDING OF DRUG TO HUMAN SERUM-ALBUMIN
T MIZUMA; M KOMORI; M UENO; HORIKOSHI, I
JOURNAL OF PHARMACY AND PHARMACOLOGY, Jun. 1991 - Photo-stability of drugs in enteral hyperalimentation solutions and its influence on the dose given by a continuous infusion.
MIZUMA TAKASHI; NAKAJIMA SAYURI; TAKASE HIROSHI; KUROSAKI TOSHIMI; HORIKOSHI ISAMU
Jpn. J. Hosp. Pharm., 1991 - CORRELATION OF PHENOL SULFOTRANSFERASE ACTIVITIES IN THE LIVER AND PLATELETS OF RAT
J NAKAMURA; T MIZUMA; M HAYASHI; S AWAZU
JOURNAL OF PHARMACY AND PHARMACOLOGY, Mar. 1990 - Protective effect of polyethylene telephthalate film on photodegradation of drugs in plabottle
T. Mizuma; S. Nakajima; H. Takase; M. Komori; T. Nakagawa; I. Horikoshi
Japanese Journal of Hospital Pharmacy, 1990 - Evaluation of dose of unstable drug administered by infusion
T. Mizuma; S. Nakajima; H. Takase; M. Komori; T. Nakagawa; I. Horikoshi
Japanese Journal of Hospital Pharmacy, 1990 - Irreversible binding of furosemide to human serum albumin by metabolic activation, photoactivation and both activations.
MIZUMA Takashi; BENET Leslie Z.; McDONAGH Anthony F.; LIN Emil T.
J. Pharmacobio-Dyn., 1990
The Pharmaceutical Society of Japan - TRANSPORT OF ACETAMINOPHEN CONJUGATES IN ISOLATED RAT HEPATOCYTES
S IIDA; T MIZUMA; N SAKUMA; M HAYASHI; S AWAZU
DRUG METABOLISM AND DISPOSITION, May 1989 - TRANSPORT OF ACETAMINOPHEN CONJUGATES IN ISOLATED RAT HEPATOCYTES
S IIDA; T MIZUMA; N SAKUMA; M HAYASHI; S AWAZU
DRUG METABOLISM AND DISPOSITION, May 1989 - CONFORMATIONAL CHANGE IN PLASMA-ALBUMIN DUE TO INTERACTION WITH ISOLATED RAT HEPATOCYTE
T HORIE; T MIZUMA; S KASAI; S AWAZU
AMERICAN JOURNAL OF PHYSIOLOGY, Apr. 1988 - ARYL SULFOTRANSFERASE IN RAT-LIVER - MULTIPLICITY AND SUBSTRATE-SPECIFICITY
J NAKAMURA; T MIZUMA; T HORIE; M HAYASHI; S AWAZU
JOURNAL OF PHARMACOBIO-DYNAMICS, Dec. 1987 - FLUORESCENCE ENERGY-TRANSFER STUDY OF THE RELATIONSHIP BETWEEN THE LONE TRYPTOPHAN RESIDUE AND DRUG-BINDING SITES IN HUMAN-SERUM ALBUMIN
S KASAI; T HORIE; T MIZUMA; S AWAZU
JOURNAL OF PHARMACEUTICAL SCIENCES, May 1987 - ALBUMIN-MEDIATED UPTAKE MECHANISM OF DRUG BY ISOLATED HEPATOCYTES
T MIZUMA; T HORIE; M HAYASHI; S AWAZU
JOURNAL OF PHARMACOBIO-DYNAMICS, Jun. 1986 - CHARACTERIZATION OF THE INTERACTION OF ALBUMIN WITH ISOLATED RAT-LIVER CELLS TO REVEAL THE MECHANISM OF ALBUMIN-MEDIATED HEPATIC TRANSPORT
T MIZUMA; T HORIE; M HAYASHI; S AWAZU
JOURNAL OF PHARMACOBIO-DYNAMICS, Mar. 1986 - HETEROGENEOUS DISTRIBUTION OF THE CONJUGATION ACTIVITY OF ACETAMINOPHEN AND PARA-NITROPHENOL IN ISOLATED RAT-LIVER CELLS
H ARAYA; T MIZUMA; T HORIE; M HAYASHI; S AWAZU
JOURNAL OF PHARMACOBIO-DYNAMICS, Feb. 1986 - FACTORS INFLUENCING DRUG SULFATE AND GLUCURONIC-ACID CONJUGATION RATES IN ISOLATED RAT HEPATOCYTES - SIGNIFICANCE OF PREINCUBATION TIME
T MIZUMA; M HAYASHI; S AWAZU
BIOCHEMICAL PHARMACOLOGY, 1985 - THE EFFECT OF ALBUMIN ON THE UPTAKE OF BROMOSULFOPHTHALEIN BY ISOLATED RAT HEPATOCYTES
T MIZUMA; T HORIE; S AWAZU
JOURNAL OF PHARMACOBIO-DYNAMICS, 1985 - FACTORS INFLUENCING DRUG SULFATE AND GLUCURONIC-ACID CONJUGATION RATES IN ISOLATED RAT HEPATOCYTES - SIGNIFICANCE OF PREINCUBATION TIME
T MIZUMA; M HAYASHI; S AWAZU
BIOCHEMICAL PHARMACOLOGY, 1985 - MULTIPLE FORMS OF ARYL SULFOTRANSFERASE FOR ACETAMINOPHEN SULFATE CONJUGATION IN RAT-LIVER CYTOSOL
T MIZUMA; H ARAYA; M HAYASHI; S AWAZU
JOURNAL OF PHARMACOBIO-DYNAMICS, 1984 - HETEROGENEOUS DISTRIBUTION OF CONJUGATION ACTIVITIES OF HARMOL IN ISOLATED RAT-LIVER CELLS
H ARAYA; T MIZUMA; T HORIE; M HAYASHI; S AWAZU
JOURNAL OF PHARMACOBIO-DYNAMICS, 1984 - PARA-NITROPHENOL SULFATION IN RAT-LIVER CYTOSOL - MULTIPLE FORMS AND SUBSTRATE-INHIBITION OF ARYL SULFOTRANSFERASE
T MIZUMA; M HAYASHI; S AWAZU
JOURNAL OF PHARMACOBIO-DYNAMICS, 1983 - PARA-NITROPHENOL SULFATE CONJUGATION WITH SUBSTRATE-INHIBITION IN RAT-LIVER CYTOSOL FRACTION
T MIZUMA; H YAMAGUCHI; M HAYASHI; S AWAZU
CHEMICAL & PHARMACEUTICAL BULLETIN, 1983 - CORRELATION OF DRUG CONJUGATIVE METABOLISM RATES BETWEEN INVIVO AND INVITRO - GLUCURONIDATION AND SULFATION OF PARA-NITROPHENOL AS A MODEL-COMPOUND IN RAT
T MIZUMA; M MACHIDA; M HAYASHI; S AWAZU
JOURNAL OF PHARMACOBIO-DYNAMICS, 1982
Books and other publications
- 生物薬剤学 ドラッグデリバリーシステム：プロドラッグ（化学修飾）化による方法
2001 - Transportability and recognizability of SGLTI for alkyl glucosides : TRN (Transportable, Recognizable ; Non-interactive) classification of glucose conjugates
2000 - Transportability and recognizability of SGLTI for alkyl glucosides : TRNC Transportable, Recognizable ; Non-interactive classification of glucose conjugates
Control and disease of Sodium dependent transport proteins and ion channels, 2000
Research Themes
