Takayuki Yoshida
| Faculty of Pharmaceutical Sciences,Department of Pharmaceutical Sciences | Assistant Professor |
Last Updated :2026/02/06
■Researcher basic information
■Career
Educational Background
Member History
- Jul. 2025 - Present
School Health Committee, Public Interest Incorporated Association Tokyo Pharmacists Association - Apr. 2023 - Present
School Pharmacist Committee, General Incorporated Association Nakano Ward Pharmacists Association - Apr. 2015 - Present
- Apr. 2013 - Present
- Feb. 2012 - Present
- 2012 - Present
- 2010 - 2015
■Research activity information
Paper
- Food Packaging Materials for One-Dose Packaging for Enhanced Stability of Hygroscopic Medications
Takayuki Yoshida; Kiyotaka Ushijima; Natsumi Nishimura; Makoto Toda; Miho Morikawa; Kazuhiro Iwasa; Takashi Tomita
Pharmaceuticals, 16 Jan. 2026, [Reviewed]
Background/Objectives: One-dose packaging is beneficial for older adults and those on multiple medications because it ensures that no doses are missed and supports medication adherence. However, conventional one-dose packaging materials have high moisture permeability, making them unsuitable for the storage of hygroscopic medications. We evaluated the barrier performance of food packaging materials against moisture and oxygen and investigated their potential to enhance the physical stability of the highly hygroscopic sodium valproate, under stressed storage conditions. Methods: Barrier performance was evaluated by measuring the water vapor transmission (WVTR) and oxygen transmission rates of each packaging material. Then, we evaluated the stability of sodium valproate tablets in different food packaging films by measuring weight change, breaking force, and visual appearance over 14 days under stressed storage conditions (35 °C and 75% relative humidity). Conventional cellophane-laminated polyethylene was used as the reference. Results: The WVTR of the food packaging films were below 2 g/m2/day, less than that of the conventional material. Tablets stored in Materials A and B showed weight increases of no more than 1.2% after 3 days, whereas the maximum increase among all food films was 3.7% (Material C). For Materials A and B, the breaking force remained measurable and the visual appearance unchanged throughout the 14-day period, whereas Material C became unmeasurable by day 14. Tablets packaged in cellophane-laminated polyethylene exhibited deliquescence, with visible deformation and stickiness within 3 days, rendering them unmeasurable. Conclusions: Food packaging materials with high barrier performance offer a practical, safe, and effective solution for one-dose packaging of hygroscopic medications, potentially expanding their clinical use and improving adherence. - Stability assessment of hygroscopic medications in one dose packaging using community pharmacist surveys and experimental storage methods
Takayuki Yoshida; Hisashi Iijima; Yumeka Washio; Makoto Toda; Miho Morikawa; Kazuhiro Iwasa; Takashi Tomita
Scientific Reports, 18 Feb. 2025, [Reviewed]
A survey of community pharmacists identified hygroscopic medications unsuitable for one-dose packaging. Stability testing showed that storage without moisture-suppression bags caused significant changes in weight and breaking force despite minimal visual changes, whereas moisture-suppression bags preserved the quality of some medications, highlighting the need for improved evaluation criteria and pharmacist awareness. - Development of a novel moisture-suppression bag for the preservation of hygroscopic medications.
Taisuke Matsuo; Takayuki Yoshida; Kiyotaka Ushijima; Takashi Doi; Yasuyuki Sadzuka; Takashi Tomita
Journal of pharmaceutical health care and sciences, 15 Feb. 2023, [Reviewed]
We developed a moisture-suppression bag for one-dose packaging of hygroscopic medications without using desiccating agents. The bag maintained internal humidity at 30–40% under high temperature and humidity and suppressed moisture absorption of potassium aspartate and sodium valproate tablets more effectively than conventional plastic bags with desiccants, offering a safer option for elderly patients. - Survey on Heated Tobacco Products in Smoking Prevention Education by School Pharmacists
Takayuki yoshida; Masakazu ishii
japaniese journal of social pharmacy, 10 Dec. 2022, [Reviewed] - Efforts to accurately determine the amount of anti-cancer drugs remaining in the healthcare environment to help improve the working environment
Masanari Takahashi; Takashi Tomita; Hirotake Takeuchi; Shunsuke Kumazawa; Takayuki Yoshida; Kenji Sumiya; Shuji Hishikawa; Masayuki Kojima
Cancer and Chemotherapy, Dec. 2022, [Reviewed] - Visualizing fluid transport inside orally disintegrating tablets and changes in tablets using real-time X-ray radiography and X-ray computed tomography
Kazuhiro Suzuki; Masahiko Yoshiki; Norio Nishikawa; Tsutomu Harada; Yoshiaki Fujita; Yuji Terui; Takayuki Yoshida; Takashi Tomita
Drug Development and Industrial Pharmacy, 12 Aug. 2022, [Reviewed]
Using synchrotron radiation–based X-ray imaging without contrast agents, we investigated the disintegration behavior of wet- and dry-compressed orally disintegrating tablets. Real-time radiography and X-ray computed tomography revealed faster water penetration in wet-compressed tablets, greater swelling in dry-compressed tablets, and void formation after water absorption.
MISC
- 居住系介護施設の誤薬事故減少に向けた松戸市薬剤師会の取り組み
Sep. 2024 - 「薬物動態の理解度向上」から「薬物治療の安全」への期待
Sep. 2024 - 千葉県内薬局薬剤師を対象とした法的責任の認知度及び賠償責任保険加入状況の実態調査
Sep. 2023 - 医療環境中に残留する抗がん薬量を正確に把握して労働環境の改善に貢献するための取り組み
Oct. 2022 - スマートフォンの録画機能を用いたビデオデブリーフィングによる医療コミュニケーション教育の手法と効果
Mar. 2022 - かかりつけ薬剤師は地域でどんな役割を果たせるのか 地域薬剤師会の在宅における麻薬譲渡を含む地域内連係と365日対応に向けての取り組み(「松戸システム」として)
Apr. 2018 - 千葉県内保険薬局における調剤事故発生時の対応状況調査報告
Oct. 2017
Lectures, oral presentations, etc.
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