Feb. 2025

Dec. 2024

Oct. 2022

Stability assessment of hygroscopic medications in one dose packaging using community pharmacist surveys and experimental storage methods
Takayuki Yoshida; Hisashi Iijima; Yumeka Washio; Makoto Toda; Miho Morikawa; Kazuhiro Iwasa; Takashi Tomita
Scientific Reports, 18 Feb. 2025, [Reviewed]
Abstract

Some medications are unsuitable for one-dose packaging due to issues such as moisture absorption. A survey of community pharmacists was conducted to understand the status of one-dose packaging and identify hygroscopic medications for stability testing. Stability was assessed using a moisture-suppression bag and clinical applications were investigated. Survey results were used to extract the medications that should be included in the one-dose package. Medications were stored with and without moisture-suppression bags, and quality was assessed using weight change and breaking force. Suvorexant, Telmisartan, Aspirin Dialuminate, Kampo extract formulations (Yokukansan and Daikenchu-tou), and Yokuinin extract tablets were selected for the stability test. Storage without moisture-suppression bags resulted in substantial changes in weight and breaking force for all tested medications; the use of moisture-suppression bags maintained the quality of some medications. Although there was a substantial difference in weight change from day 3, there was almost no change in appearance. Currently, the decision to include hygroscopic pharmaceuticals in a single package based on changes in appearance is insufficient. However, further research is necessary to justify the decision not to include hygroscopic pharmaceuticals in such packaging. Therefore, pharmaceutical companies should cultivate appropriate awareness and information literacy of pharmacists should be improved.

Development of a novel moisture-suppression bag for the preservation of hygroscopic medications.
Taisuke Matsuo; Takayuki Yoshida; Kiyotaka Ushijima; Takashi Doi; Yasuyuki Sadzuka; Takashi Tomita
Journal of pharmaceutical health care and sciences, 15 Feb. 2023, [Reviewed]
BACKGROUND: One-dose packaging is frequently used in Japan for elderly patients who are prescribed several medications. It is useful for easy administration and the prevention of misuse or missed medications. Hygroscopic medications are not suitable for one-dose packaging because moisture absorption may alter their properties. Plastic bags with desiccating agents are sometimes used to store hygroscopic medicines in one-dose packaging. However, the relationship between the quantity of desiccating agents and their safety in the storage of hygroscopic medications is poorly understood. Furthermore, older adults might accidentally consume desiccating agents used in food preservation. In this study, we developed a bag that suppresses the moisture absorption of hygroscopic medications without the use of desiccating agents. METHODS: The bag was manufactured using polyethylene terephthalate, polyethylene, and aluminum film on the outside, and unified with a desiccating film on the inside. RESULTS: The relative humidity (RH) in the bag was maintained at approximately 30-40% when the bag was stored at 75% RH and 35 °C. The manufactured bag's moisture suppressing effect was better than that of plastic bags with desiccating agents when the hygroscopic medications, potassium aspartate and sodium valproate tablets, were stored at 75% RH and 35 °C for 4 weeks. CONCLUSIONS: The moisture-suppression bag effectively stored and preserved hygroscopic medications and was more effective in inhibiting moisture absorption than plastic bags with desiccating agents under high temperature and humidity conditions. The moisture-suppression bags are expected to be useful for elderly patients who are prescribed several medications in one-dose packaging.

Survey on Heated Tobacco Products in Smoking Prevention Education by School Pharmacists
Takayuki yoshida; Masakazu ishii
japaniese journal of social pharmacy, 10 Dec. 2022, [Reviewed]

Efforts to accurately determine the amount of anti-cancer drugs remaining in the healthcare environment to help improve the working environment　　　　　　　　　　　　　　　
Masanari Takahashi; Takashi Tomita; Hirotake Takeuchi; Shunsuke Kumazawa; Takayuki Yoshida; Kenji Sumiya; Shuji Hishikawa; Masayuki Kojima
Cancer and Chemotherapy, Dec. 2022, [Reviewed]

Visualizing fluid transport inside orally disintegrating tablets and changes in tablets using real-time X-ray radiography and X-ray computed tomography
Kazuhiro Suzuki; Masahiko Yoshiki; Norio Nishikawa; Tsutomu Harada; Yoshiaki Fujita; Yuji Terui; Takayuki Yoshida; Takashi Tomita
Drug Development and Industrial Pharmacy, 12 Aug. 2022, [Reviewed]

製剤情報に基づいた日本薬局方崩壊試験法と口腔内崩壊錠試験器による崩壊時間の比較 ～ドネペジル口腔内崩壊錠を対象とした検討～
Jul. 2022, [Reviewed]

居住系介護施設における誤薬事故の減少及び至適薬物治療の実現に向けた薬剤師の取り組み　　　　　　　　　　　　　　　
Mar. 2022, [Reviewed]

地域ケアの実践 松戸市常盤平地区事例集 −この教訓を全国に−　　　　　　　　　　　　　　　
Joint work
May 2017

居住系介護施設の誤薬事故減少に向けた松戸市薬剤師会の取り組み　　　　　　　　　　　　　　　
23 Sep. 2024

A survey on the awareness of legal liability and the status of liability insurance subscription among pharmacists in Chiba Prefecture.　　　　　　　　　　　　　　　
Takayuki yoshida; Takanori tsuchiya; Tatsuya nakamura; Kazuyoshi arai
The 56th Annual Meeting of the Japanese Pharmaceutical Association, Sep. 2023

かかりつけ薬剤師は地域でどんな役割を果たせるのか 地域薬剤師会の在宅における麻薬譲渡を含む地域内連係と365日対応に向けての取り組み(「松戸システム」として)　　　　　　　　　　　　　　　
Apr. 2018

薬局と診療所との連携 早期認知症への対応　　　　　　　　　　　　　　　
Feb. 2018

千葉県内保険薬局における調剤事故発生時の対応状況調査報告　　　　　　　　　　　　　　　
Oct. 2017

千葉県内保険薬局における調剤事故発生時の対応状況調査報告　　　　　　　　　　　　　　　
Feb. 2017

来局者から地域へ 活動範囲を広げた認知症対応報告　　　　　　　　　　　　　　　
Oct. 2016

PHARM-2E分析法による研修報告とアンケート結果から分かる今後の課題　　　　　　　　　　　　　　　
Nov. 2015

薬局と診療所連携における薬局薬剤師の『気づき』『つなぎ』による認知症疑い早期対応の有用性検討　　　　　　　　　　　　　　　
Nov. 2015

地域薬剤師会の在宅における麻薬譲渡を含む地域内連携と365日対応にむけての取組み　　　　　　　　　　　　　　　
Oct. 2014

2022
日本老年薬学会　　　　　　　　　　　　　　　

Sep. 2021
日本薬局学会　　　　　　　　　　　　　　　

Aug. 2021
日本医療薬学会　　　　　　　　　　　　　　　

Jul. 2021
日本社会薬学会