Paper

• Gene Deletion of Microsomal Prostaglandin E Synthase-1 Suppresses Chemically Induced Skin Carcinogenesis
  YUKA SASAKI; HIROSHI KUWATA; ERI AIDA; TSUBASA OCHIAI; DAISUKE KAMEI; YOSHIHITO NAKATANI; SHUNTARO HARA
  Anticancer Research, Mar. 2021

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• Coordinated action of microsomal prostaglandin E synthase-1 and prostacyclin synthase on contact hypersensitivity
  Tsubasa Ochiai; Yuka Sasaki; Hiroshi Kuwata; Yoshihito Nakatani; Chieko Yokoyama; Shuntaro Hara
  Biochemical and Biophysical Research Communications, Mar. 2021

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• Involvement of prostacyclin synthase in high-fat-diet-induced obesity
  Yuka Sasaki; Hiroshi Kuwata; Moe Akatsu; Yuri Yamakawa; Tsubasa Ochiai; Emiko Yoda; Yoshihito Nakatani; Chieko Yokoyama; Shuntaro Hara
  Prostaglandins & Other Lipid Mediators, Dec. 2020

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• Gene Deletion of Calcium-Independent Phospholipase A2γ (iPLA2γ) Suppresses Adipogenic Differentiation of Mouse Embryonic Fibroblasts.
  Emiko Yoda; Keiko Hachisu; Hiroshi Kuwata; Yoshihito Nakatani; Shuntaro Hara
  Biological & pharmaceutical bulletin, 2020
  Adipogenic differentiation is a complex process by which fibroblast-like undifferentiated cells are converted into cells that accumulate lipid droplets. We here investigated the effect of gene deletion of calcium-independent phospholipase A2γ (iPLA2γ), a membrane-bound PLA2 enzyme, on adipogenic differentiation in mice. Since iPLA2γ knockout (KO) mice showed reduced fat volume and weight, we prepared mouse embryonic fibroblasts (MEF) from wild-type (WT) and iPLA2γ KO mice and examined the effect of iPLA2γ deletion on in vitro adipogenic differentiation. iPLA2γ increased during adipogenic differentiation in WT mouse-derived MEFs, and the differentiation was partially abolished in iPLA2γ KO-derived MEFs. In KO-derived MEFs, the inductions of peroxisome proliferator activator receptor γ (PPARγ) and CAAT/enhancer-binding protein α (C/EBPα) were also reduced during adipogenic differentiation, and the reductions in PPARγ and C/EBPα expressions and the defect in adipogenesis were restored by treatment with troglitazone, a PPARγ ligand. These results indicate that iPLA2γ might play a critical role in adipogenic differentiation by regulating PPARγ expression.

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• Long-chain acyl-CoA synthetase 4 participates in the formation of highly unsaturated fatty acid-containing phospholipids in murine macrophages
  Hiroshi Kuwata; E. Nakatani; Satoko Shimbara-Matsubayashi; Fumihiro Ishikawa; Motoko Shibanuma; Yuka Sasaki; E. Yoda; Yoshihito Nakatani; Shuntaro Hara
  Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, Nov. 2019, [Reviewed]

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• Calcium-independent phospholipase A 2 γ (iPLA 2 γ) and its roles in cellular functions and diseases
  Shuntaro Hara; Emiko Yoda; Yuka Sasaki; Yoshihito Nakatani; Hiroshi Kuwata
  Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, Jun. 2019, [Reviewed]

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• Calcium-independent phospholipase A2γ (iPLA2γ) and its roles in cellular functions and diseases.
  Shuntaro Hara; Emiko Yoda; Yuka Sasaki; Yoshihito Nakatani; Hiroshi Kuwata
  Biochimica et biophysica acta. Molecular and cell biology of lipids, Jun. 2019, [Reviewed]
  Calcium-independent phospholipase A2γ (iPLA2γ)/patatin-like phospholipase domain-containing lipase 8 (PNPLA8) is one of the iPLA2 enzymes, which do not require Ca2+ ion for their activity. iPLA2γ is a membrane-bound enzyme with unique features, including the utilization of four distinct translation initiation sites and the presence of mitochondrial and peroxisomal localization signals. This enzyme is preferentially distributed in the mitochondria and peroxisomes and is thought to be responsible for the maintenance of lipid homeostasis in these organelles. Thus, both the overexpression and the deletion of iPLA2γ in vivo caused mitochondrial abnormalities and dysfunction. Roles of iPLA2γ in lipid mediator production and cytoprotection against oxidative stress have also been suggested by in vitro and in vivo studies. The dysregulation of iPLA2γ can therefore be a critical factor in the development of many diseases, including metabolic diseases and cancer. In this review, we provide an overview of the biochemical properties of iPLA2γ and then summarize the current understanding of the in vivo roles of iPLA2γ revealed by knockout mouse studies.

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• The group VIA calcium-independent phospholipase A2 and NFATc4 pathway mediates IL-1β-induced expression of chemokines CCL2 and CXCL10 in rat fibroblasts.
  Hiroshi Kuwata; Chihiro Yuzurihara; Natsumi Kinoshita; Yuki Taki; Yuki Ikegami; Sana Washio; Yushi Hirakawa; Emiko Yoda; Toshihiro Aiuchi; Hiroyuki Itabe; Yoshihito Nakatani; Shuntaro Hara
  The FEBS journal, Jun. 2018, [Reviewed]
  Chemokines are secreted proteins that regulate cell migration and are involved in inflammatory and immune responses. Here, we sought to define the functional crosstalk between the lipid signaling and chemokine signaling. We obtained evidence that the induction of some chemokines is regulated by group VIA calcium-independent phospholipase A2 β (iPLA2 β) in IL-1β-stimulated rat fibroblastic 3Y1 cells. Treatment of 3Y1 cells with IL-1β elicited an increased release of chemotactic factor(s) for monocytic THP-1 cells into culture medium in a time-dependent manner. Inhibitor studies revealed that an intracellular PLA2 inhibitor, arachidonoyl trifluoromethyl ketone (AACOCF3 ), but not the cyclooxygenase inhibitor indomethacin, attenuated the release of chemotactic factor(s). The chemotactic activity was inactivated by treatment with either heat or proteinase K, suggesting this chemotactic factor(s) is a proteinaceous factor(s). We purified the chemotactic factor(s) from the conditioned medium of IL-1β-stimulated 3Y1 cells using a heparin column and identified several chemokines, including CCL2 and CXCL10. The inducible expressions of CCL2 and CXCL10 were significantly attenuated by pretreatment with AACOCF3 . Gene silencing using siRNA revealed that the inductions of CCL2 and CXCL10 were attenuated by iPLA2 β knockdown. Additionally, the transcriptional activation of nuclear factor of activated T-cell proteins (NFATs), but not nuclear factor-κB, by IL-1β stimulation was markedly attenuated by the iPLA2 inhibitor bromoenol lactone, and NFATc4 knockdown markedly attenuated the IL-1β-induced expression of both CCL2 and CXCL10. Collectively, these results indicated that iPLA2 β plays roles in IL-1β-induced chemokine expression, in part via NFATc4 signaling.

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• Cytosolic Prostaglandin E Synthase Is Involved in c-Fos Expression in Rat Fibroblastic 3Y1 Cells
  Yoshihito Nakatani; Yuki Miyazaki; Shuntaro Hara
  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Nov. 2017, [Reviewed]

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• Regulatory Functions of Phospholipase A2.
  Murakami M; Nakatani Y; Atsumi GI; Inoue K; Kudo I
  Critical reviews in immunology, 2017, [Reviewed]

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• Genetic-deletion of Cyclooxygenase-2 Downstream Prostacyclin Synthase Suppresses Inflammatory Reactions but Facilitates Carcinogenesis, unlike Deletion of Microsomal Prostaglandin E Synthase-1
  Yuka Sasaki; Shuhei Kamiyama; Azusa Kamiyama; Konomi Matsumoto; Moe Akatsu; Yoshihito Nakatani; Hiroshi Kuwata; Yukio Ishikawa; Toshiharu Ishii; Chieko Yokoyama; Shuntaro Hara
  SCIENTIFIC REPORTS, Nov. 2015, [Reviewed]

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• Role of microsomal prostaglandin E synthase-1 (mPGES-1)-derived prostaglandin E-2 in colon carcinogenesis
  Yuka Sasaki; Yoshihito Nakatani; Shuntaro Hara
  PROSTAGLANDINS & OTHER LIPID MEDIATORS, Sep. 2015, [Reviewed]

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• Group VIB Calcium-Independent Phospholipase A(2) (iPLA(2)gamma) Regulates Platelet Activation, Hemostasis and Thrombosis in Mice
  Emiko Yoda; Kohmi Rai; Mai Ogawa; Yuki Takakura; Hiroshi Kuwata; Hidenori Suzuki; Yoshihito Nakatani; Makoto Murakami; Shuntaro Hara
  PLOS ONE, Oct. 2014, [Reviewed]

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• Role of long-chain acyl-coenzyme A synthetases in the regulation of arachidonic acid metabolism in interleukin 1β-stimulated rat fibroblasts
  Hiroshi Kuwata; Makiko Yoshimura; Yuka Sasaki; Emiko Yoda; Yoshihito Nakatani; Ichiro Kudo; Shuntaro Hara
  Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, Jan. 2014, [Reviewed]

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• Role of long-chain acyl-coenzyme A synthetases in the regulation of arachidonic acid metabolism in interleukin 1β-stimulated rat fibroblasts.
  Hiroshi Kuwata; Makiko Yoshimura; Yuka Sasaki; Emiko Yoda; Yoshihito Nakatani; Ichiro Kudo; Shuntaro Hara
  Biochimica et biophysica acta, Jan. 2014, [Reviewed]
  Acyl coenzyme A synthetase long-chain family members (ACSLs) are a family of enzymes that convert long-chain free fatty acids into their acyl-CoAs and play an important role in fatty acid metabolism. Here we show the role of ACSL isozymes in interleukin (IL)-1β-induced arachidonic acid (AA) metabolism in rat fibroblastic 3Y1 cells. Treatment of 3Y1 cells with triacsin C, an ACSL inhibitor, markedly enhanced the IL-1β-induced prostaglandin (PG) biosynthesis. Small interfering RNA-mediated knockdown of endogenous Acsl4 expression increased significantly the release of AA metabolites, including PGE2, PGD2, and PGF2α, compared with replicated control cells, whereas knockdown of Acsl1 expression reduced the IL-1β-induced release of AA metabolites. Experiments with double knockdown of Acsl4 and intracellular phospholipase A2 (PLA2) isozymes revealed that cytosolic PLA2α, but not calcium-independent PLA2s, is involved in the Acsl4 knockdown-enhanced PG biosynthesis. Electrospray ionization mass spectrometry of cellular phospholipids bearing AA showed that the levels of some, if not all, phosphatidylcholine (PC) and phosphatidylinositol species in Acsl4 knockdown cells were decreased after IL-1β stimulation, while those in control cells were not so obviously decreased. In Acsl1 knockdown cells, the levels of some AA-bearing PC species were reduced even in the unstimulated condition. Collectively, these results suggest that Acsl isozymes play distinct roles in the control of AA remodeling in rat fibroblasts: Acsl4 acts as the first step of enzyme for AA remodeling following IL-1β stimulation, and Acsl1 is involved in the maintenance of some AA-containing PC species.

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• Microsomal prostaglandin E synthase-1 is induced in alzheimer's disease and its deletion mitigates alzheimer's disease-like pathology in a mouse model
  Yoshiharu Akitake; Yoshihito Nakatani; Daisuke Kamei; Masato Hosokawa; Hiroyasu Akatsu; Satoshi Uematsu; Shizuo Akira; Ichiro Kudo; Shuntaro Hara; Mitsuo Takahashi
  JOURNAL OF NEUROSCIENCE RESEARCH, Jul. 2013, [Reviewed]

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• Deletion of microsomal prostaglandin E synthase-1 protects neuronal cells from cytotoxic effects of beta-amyloid peptide fragment 31-35
  Yukiko Kuroki; Yuka Sasaki; Daisuke Kamei; Yoshiharu Akitake; Mitsuo Takahashi; Satoshi Uematsu; Shizuo Akira; Yoshihito Nakatani; Ichiro Kudo; Shuntaro Hara
  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Aug. 2012, [Reviewed]

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• Involvement of the constitutive prostaglandin E synthase cPGES/p23 in expression of an initial prostaglandin E-2 inactivating enzyme, 15-PGDH
  Yoshihito Nakatani; Yutaka Hokonohara; Yusuke Tajima; Ichiro Kudo; Shuntaro Hara
  PROSTAGLANDINS & OTHER LIPID MEDIATORS, Apr. 2011, [Reviewed]

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• Mitochondrial dysfunction and reduced prostaglandin synthesis in skeletal muscle of Group VIB Ca2+-independent phospholipase A(2)gamma-deficient mice
  Emiko Yoda; Keiko Hachisu; Yoshitaka Taketomi; Kotomi Yoshida; Masanori Nakamura; Kazutaka Ikeda; Ryo Taguchi; Yoshihito Nakatani; Hiroshi Kuwata; Makoto Murakami; Ichiro Kudo; Shuntaro Hara
  JOURNAL OF LIPID RESEARCH, Oct. 2010, [Reviewed]

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• Prostaglandin E synthases: Understanding their pathophysiological roles through mouse genetic models
  Shuntaro Hara; Daisuke Kamei; Yuka Sasaki; Akemi Tanemoto; Yoshihito Nakatani; Makoto Murakami
  BIOCHIMIE, Jun. 2010, [Reviewed]

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• Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis
  Daisuke Kamei; Makoto Murakami; Yuka Sasaki; Yoshihito Nakatani; Masataka Majima; Yukio Ishikawa; Toshiharu Ishii; Satoshi Uematsu; Shizuo Akira; Shuntaro Hara; Ichiro Kudo
  BIOCHEMICAL JOURNAL, Jan. 2010, [Reviewed]

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• 膜結合型Ca2+非依存性ホスホリパーゼA2(iPLA2γ)の細胞内機能解析　　　　　　　　　　　　　　　
  Nov. 2008
• 細胞内ホスホリパーゼA2によるケモカイン発現調節　　　　　　　　　　　　　　　
  Nov. 2008
• 膜結合型Ca2+非依存性ホスホリパーゼA2(iPLA2γ)の細胞内機能解析　　　　　　　　　　　　　　　
  Mar. 2008
• 膜結合型カルシウム非依存性ホスホリパーゼA2(iPLA2γ)の機能解析　　　　　　　　　　　　　　　
  Mar. 2008
• Regulatory mechanisms for cytosolic prostaglandin E synthase, cPGES/p23
  Yoshihito Nakatani; Ichiro Kudo
  NEW FRONTIERS IN LIFESTYLE-RELATED DISEASES, 2008, [Reviewed]
• Knockout mice lacking cPGES/p23, a constitutively expressed PGE(2) synthetic enzyme, are peri-natally lethal
  Yoshihito Nakatani; Yutaka Hokonohara; Shigeru Kakuta; Katsuko Sudo; Yolchiro Iwakura; Ichiro Kudo
  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Oct. 2007, [Reviewed]

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• A novel role of group VIB calcium-independent phospholipase A(2) (iPLA(2)gamma) in the inducible expression of group IIA secretory PLA(2) in rat fibroblastic cells
  Hiroshi Kuwata; Chikako Fujimoto; Emiko Yoda; Satoko Shimbara; Yoshihito Nakatani; Shuntaro Hara; Makoto Murakami; Ichiro Kudo
  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 2007, [Reviewed]

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• Immediate prostaglandin E-2 synthesis in rat 3Y1 fibroblasts following vasopressin V1a receptor stimulation
  Yoshihito Nakatani; Yuka Chin; Shuntaro Hara; Ichiro Kudo
  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Mar. 2007, [Reviewed]

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• IIA型分泌性ホスホリパーゼA2の発現調節機構の解析　　　　　　　　　　　　　　　
  Mar. 2006
• Group VIBCa2+-independent phospholipase A(2)gamma promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipases A(2)
  M Murakami; S Masuda; K Ueda-Semmyo; E Yoda; H Kuwata; Y Takanezawa; J Aoki; H Arai; H Sumimoto; Y Ishikawa; T Ishii; Y Nakatani; Kudo, I
  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2005, [Reviewed]

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• Reduced pain hypersensitivity and inflammation in mice lacking microsomal prostaglandin E synthase-1
  D Kamei; K Yamakawa; Y Takegoshi; M Mikami-Nakanishi; Y Nakatani; S Oh-ishi; H Yasui; Y Azuma; N Hirasawa; K Ohuchi; H Kawaguchi; Y Ishikawa; T Ishii; S Uematsu; S Akira; M Murakami; Kudo, I
  JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 2004, [Reviewed]

  DOI URL
• Regulation of cytosolic prostaglandin E synthase by phosphorylation
  T Kobayashi; Y Nakatani; T Tanioka; M Tsujimoto; S Nakajo; K Nakaya; M Murakami; Kudo, I
  BIOCHEMICAL JOURNAL, Jul. 2004, [Reviewed]

  DOI URL
• Subcellular localization and regulation of hypoxia-inducible factor-2 alpha in vascular endothelial cells
  R Takahashi; C Kobayashi; Y Kondo; Y Nakatani; Kudo, I; M Kunimoto; N Imura; S Hara
  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Apr. 2004, [Reviewed]

  DOI URL
• 膜結合型Ca2+非依存性ホスホリパーゼA2(iPLA2γ)の免疫化学的・酵素学的解析　　　　　　　　　　　　　　　
  Mar. 2004
• Enzymes involved in arachidonic acid metabolism
  Yoshihito Nakatani; Ichiro Kudo
  Japanese Journal of Allergology, 2004, [Reviewed]
• Contribution of membrane-associated prostaglandin E-2 synthase to bone resorption
  M Saegusa; M Murakami; Y Nakatani; K Yamakawa; M Katagiri; K Matsuda; K Nakamura; Kudo, I; H Kawaguchi
  JOURNAL OF CELLULAR PHYSIOLOGY, Dec. 2003, [Reviewed]

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• Coupling between cyclooxygenases and prostaglandin F2α synthase: Detection of an inducible, glutathione-activated, membrane-bound prostaglandin F2α-synthetic activity
  Karin Nakashima; Noriko Ueno; Daisuke Kamei; Toshihiro Tanioka; Yoshihito Nakatani; Makoto Murakami; Ichiro Kudo
  Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 21 Jul. 2003

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• Coupling between cyclooxygenases and prostaglandin F(2alpha) synthase. Detection of an inducible, glutathione-activated, membrane-bound prostaglandin F(2alpha)-synthetic activity.
  Nakashima K; Ueno N; Kamei D; Tanioka T; Nakatani Y; Murakami M; Kudo I
  Biochimica et biophysica acta, Jul. 2003, [Reviewed]
  Distinct functional coupling between cyclooxygenases (COXs) and specific terminal prostanoid synthases leads to phase-specific production of particular prostaglandins (PGs). In this study, we examined the coupling between COX isozymes and PGF synthase (PGFS). Co-transfection of COXs with PGFS-I belonging to the aldo-keto reductase family into HEK293 cells resulted in increased production of PGF(2alpha) only when a high concentration of exogenous arachidonic acid (AA) was supplied. However, this enzyme failed to produce PGF(2alpha) from endogenous AA, even though significant increase in PGF(2alpha) production occurred in cells transfected with COX-2 alone. This poor COX/PGFS-I coupling was likely to arise from their distinct subcellular localization. Measurement of PGF(2alpha)-synthetic enzyme activity in homogenates of several cells revealed another type of PGFS activity that was membrane-bound, glutathione (GSH)-activated, and stimulus-inducible. In vivo, membrane-bound PGFS activity was elevated in the lung of lipopolysaccharide-treated mice. Taken together, our results suggest the presence of a novel, membrane-associated form of PGFS that is stimulus-inducible and is likely to be preferentially coupled with COX-2.

  DOI URL 2
• Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis
  D Kamei; M Murakami; Y Nakatani; Y Ishikawa; T Ishii; Kudo, I
  JOURNAL OF BIOLOGICAL CHEMISTRY, May 2003, [Reviewed]

  DOI URL
• Regulation of cytosolic prostaglandin E-2 synthase by 90-kDa heat shock protein
  T Tanioka; Y Nakatani; T Kobayashi; M Tsujimoto; S Oh-ishi; M Murakami; Kudo, I
  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Apr. 2003, [Reviewed]

  DOI URL
• 膜結合型PGF合成酵素の解析　　　　　　　　　　　　　　　
  Aug. 2002
• Prostaglandin E synthase
  M Murakami; Y Nakatani; T Tanioka; Kudo, I
  PROSTAGLANDINS & OTHER LIPID MEDIATORS, Aug. 2002, [Reviewed]
• Prostaglandin E synthase.
  Murakami M; Nakatani Y; Tanioka T; Kudo I
  Prostaglandins & other lipid mediators, Aug. 2002, [Reviewed]

  DOI URL
• 膜結合型プロスタグランジンF合成酵素の検出　　　　　　　　　　　　　　　
  Mar. 2002
• Prostaglandin E2 synthases
  Yoshihito Nakatani; Ichiro Kudo
  Folia Pharmacologica Japonica, 2002, [Reviewed]

  DOI URL 2
• Type IIA secretory PLA(2)-mediated delayed PGE(2) biosynthesis is regulated by the products of the cytosolic PLA(2)
  H Kuwata; S Yamamoto; Y Nakatani; M Murakami; Kudo, I
  EICOSANOIDS AND OTHER BIOACTIVE LIPIDS IN CANCER, INFLAMMATION, AND RADIATION INJURY, 5, 2002, [Reviewed]
• Cytosolic phospholipase A2 alpha interacts with microtubules
  Y Nakatani; S Sunaga; M Murakami; Kudo, I
  EICOSANOIDS AND OTHER BIOACTIVE LIPIDS IN CANCER, INFLAMMATION, AND RADIATION INJURY, 5, 2002, [Reviewed]
• ラット神経系における細胞質型プロスタグランジンE合成酵素の局在　　　　　　　　　　　　　　　
  Sep. 2001
• 細胞質ホスホリパーゼA2とビメンチンの結合の解析　　　　　　　　　　　　　　　
  Mar. 2001
• Studies on a mechanism by which cytosolic phospholipase A2 regulates the expression and function of type IIA secretory phospholipase A2
  H. Kuwata; S. Yamamoto; Y. Miyazaki; S. Shimbara; Y. Nakatani; H. Suzuki; N. Ueda; S. Yamamoto; M. Murakami; I. Kudo
  Journal of Immunology, 01 Oct. 2000, [Reviewed]

  DOI URL
• Molecular identification of cytosolic prostaglandin E-2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E-2 biosynthesis
  T Tanioka; Y Nakatani; N Semmyo; M Murakami; Kudo, I
  JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 2000, [Reviewed]
• Regulation of prostaglandin E-2 biosynthesis by inducible membrane-associated prostaglandin E-2 synthase that acts in concert with cyclooxygenase-2
  M Murakami; H Naraba; T Tanioka; N Semmyo; Y Nakatani; F Kojima; T Ikeda; M Fueki; A Ueno; S Oh-ishi; Kudo, I
  JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 2000, [Reviewed]
• cPLA2とvimentinの結合の解析　　　　　　　　　　　　　　　
  Aug. 2000
• PGE2合成酵素の機能解析
  Jul. 2000
• プロスタグランジンE2合成酵素(PGES)の同定と生物学的意義の解明　　　　　　　　　　　　　　　
  May 2000
• Identification of a cellular protein that functionally interacts with the C2 domain of cytosolic phospholipase A(2)alpha
  Y Nakatani; T Tanioka; S Sunaga; M Murakami; Kudo, I
  JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2000, [Reviewed]
• 誘導型プロスタグランジンE2合成酵素の精製とその性状解析　　　　　　　　　　　　　　　
  Aug. 1999
• 細胞質ホスホリパーゼA2とビメンチンの機能的相互作用の解析　　　　　　　　　　　　　　　
  Aug. 1999
• Characterization of heparin low-affinity phospholipase A(1) present in brain and testicular tissue
  S Uchiyama; Y Miyazaki; Y Amakasu; H Kuwata; Y Nakatani; G Atsumi; M Murakami; Kudo, I
  JOURNAL OF BIOCHEMISTRY, Jun. 1999, [Reviewed]
• 細胞質ホスホリパーゼA2の活性調節機構　　　　　　　　　　　　　　　
  May 1999
• 細胞質ホスホリパーゼA2(cPLA2)とビメンチンの相互作用の解析　　　　　　　　　　　　　　　
  Mar. 1999
• 誘導型プロスタグランジンE2合成酵素の検出とその性状解析　　　　　　　　　　　　　　　
  Mar. 1999
• Fas-induced arachidonic acid release is mediated by Ca2+-independent phospholipase A(2) but not cytosolic phospholipase A(2) which undergoes proteolytic inactivation
  G Atsumi; M Tajima; A Hadano; Y Nakatani; M Murakami; Kudo, I
  JOURNAL OF BIOLOGICAL CHEMISTRY, May 1998, [Reviewed]

  DOI URL
• 誘導型PGESの検出とその性状解析　　　　　　　　　　　　　　　
  Mar. 1998
• Cytosolic phospholipase A(2) is required for cytokine-induced expression of type IIA secretory phospholipase A(2) that mediates optimal cyclooxygenase-2-dependent delayed prostaglandin E-2 generation in rat 3Y1 fibroblasts
  H Kuwata; Y Nakatani; M Murakami; Kudo, I
  JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 1998, [Reviewed]
• Cancer cells isolated from malignant pleural and peritoneal effusions inhibit phospholipase A2 activity in human polymorphonuclear leukocytes
  Masayoshi Abe; Hisao Kitsuki; Sachiko Saruwatari; Hiroshi Asoh; Tsugutomo Sakurada; Hiroshi Kuwata; Yoshihito Nakatani; Ichiro Kudo; Tatsuo Furukawa
  Cancer Letters, 23 Dec. 1997, [Reviewed]

  DOI URL
• Prostaglandin E-2 amplifies cytosolic phospholipase A(2)- and cyclooxygenase-2-dependent delayed prostaglandin E-2 generation in mouse osteoblastic cells - Enhancement by secretory phospholipase A(2)
  M Murakami; H Kuwata; Y Amakasu; S Shimbara; Y Nakatani; G Atsumi; Kudo, I
  JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 1997, [Reviewed]

  DOI URL
• Characterization and molecular cloning of mouse type II phospholipase A(2)
  N Hara; M Murakami; Y Nakatani; K Inoue; Kudo, I
  EICOSANOIDS AND OTHER BIOACTIVE LIPIDS IN CANCER, INFLAMMATION, AND RADIATION INJURY 3, 1997, [Reviewed]
• Phospholipase A(2) inhibitory activity in lung cancer cell lines
  M Abe; T Sakurada; H Kuwata; Y Nakatani; Kudo, I; T Furukawa
  RECENT ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH, 1997, [Reviewed]
• Regulatory functions of phospholipase A(2)
  M Murakami; Y Nakatani; G Atsumi; K Inoue; Kudo, I
  CRITICAL REVIEWS IN IMMUNOLOGY, 1997, [Reviewed]
• Type II secretory phospholipase A(2) associated with cell surfaces via C-terminal heparin-binding lysine residues augments stimulus-initiated delayed prostaglandin generation
  M Murakami; Y Nakatani; Kudo, I
  JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 1996, [Reviewed]
• Detection and purification of two 14 kDa phospholipase A2 isoforms in rat kidney: their role in eicosanoid synthesis
  Shuntaro Hara; Ichiro Kudo; Takeshi Komatani; Katsuhiko Takahashi; Yoshihito Nakatani; Yasuhiro Natori; Mieko Ohshima; Keizo Inoue
  Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism, Jun. 1995

  DOI URL
• DUAL REGULATION OF CYTOSOLIC PHOSPHOLIPASE A(2) IN MAST-CELLS AFTER CROSS-LINKING OF FC-EPSILON-RECEPTOR
  Y NAKATANI; M MURAKAMI; KUDO, I; K INOUE
  JOURNAL OF IMMUNOLOGY, Jul. 1994, [Reviewed]