Akihiko Ushigome
| Faculty of Health Care,Department of Judo Physical Therapy | Professor |
| Graduate School of Health Sciences,Master's and Doctoral Programs in Judo Physical Therapy | Professor |
Last Updated :2025/10/07
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Field Of Study
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Career
■Research activity information
Paper
- Involvement of glutamatergic mechanisms in the median preoptic nucleus in the dipsogenic response induced by angiotensinergic activation of the subfornical organ in rats.
Akihiko Ushigome; Katsumasa Momoi; Makoto Takahashi; Junichi Tanaka
Experimental brain research, Jan. 2020, [Reviewed]
Experiments were done to investigate the role of glutamatergic systems in the median preoptic nucleus (MnPO) in the water ingestion induced by administration of angiotensin II (ANG II) in the subfornical organ (SFO) in the awake rat. Microdialysis methods were utilized to quantify the extracellular content of glutamate (Glu) in the region of MnPO. Microinjection of ANG II (10-10 M) into the SFO significantly increased the release of Glu in the MnPO in the rats under the condition that water is available for drinking and the rats under the condition that water is not available for drinking. The amount of initial maximal increases in the Glu levels elicited by the ANG II injection was quite similar in drinking and non-drinking rats, whereas the duration of the response was much longer in non-drinking than in drinking rats. The amount of water ingestion in 20 min immediately after the ANG II injection was significantly enhanced by previous injections of N-methyl-D-aspartate (NMDA, 10 μM) into the MnPO, while the ANG II-induced water ingestion was attenuated by pretreatment with the NMDA antagonist dizocilpine (MK-801, 10 μM). The amount of water intake elicited by the ANG II injection into the SFO was enhanced by previous injections of either the non-NMDA agonist kainic acid (KA, 50 μM) or quisqualic acid (QA, 50 μM) into the MnPO. On the contrary, the ANG II-induced drinking response was diminished by pretreatment with the non-NMDA antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 10 μM) in the MnPO. Each injection of NMDA, KA, and QA into the MnPO produced drinking behavior. These results imply that the glutamatergic neural pathways to the MnPO may transmit the information for eliciting drinking in response to ANG II acting at the SFO. Our data further provide evidence that the ANG II-induced dipsogenic response may be mediated through both NMDA and non-NMDA glutamatergic receptor mechanisms in the MnPO. - 教育原理について考える
Feb. 2017 - A Study of Comparison between Student Self Evaluation and Evaluation with Kindergarten
牛込 彰彦
埼玉純真短期大学研究論文集, 2014 - A Study of Comparison between Student Self Evaluation and Evaluation with Nursery school
牛込 彰彦
埼玉純真短期大学研究論文集, 2013 - Drinking induced by angiotensin 2 activation of glutamatergic projections from the subfornical organ to the median preoptic nucleus in rats
牛込 彰彦; 丹原 香菜子; 林 泰資
Medicine and biology, 10 Oct. 2007, [Reviewed] - ラット終板脈管器官からのGABA作動性入力による正中視索前野のノルアドレナリン放出調節
Dec. 2005, [Reviewed] - Modulation of noradrenaline release in the median preoptic area by GABAergic inputs from the organum vasculosum of the lamina terminalis in the rat
A Ushigome; M Nomura; J Tanaka
NEUROCHEMISTRY INTERNATIONAL, Feb. 2004, [Reviewed] - Paraventricular noradrenergic systems participate in angiotensin II-induced drinking
A Ushigome; J Tanaka; K Kariya; M Nomura
PEPTIDES, Dec. 2002, [Reviewed] - GABAergic systems in the nucleus tractus solitarius regulate noradrenaline release in the subfornical organ area in the rat
J Tanaka; N Mashiko; A Kawakami; A Ushigome; M Nomura
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, Sep. 2002, [Reviewed] - Responses of raphe nucleus projecting subfornical organ neurons to angiotensin II in rats
J Tanaka; A Ushigome; K Hori; M Nomura
BRAIN RESEARCH BULLETIN, Feb. 1998, [Reviewed] - ラットの迷路学習における海馬モノアミン作動性ニューロンの役割に関する研究
Mar. 1996, [Reviewed] - RESPONSES OF MEDIAN PREOPTIC NEURONS PROJECTING TO THE HYPOTHALAMIC PARAVENTRICULAR NUCLEUS TO OSMOTIC STIMULATION IN WISTAR-KYOTO AND SPONTANEOUSLY HYPERTENSIVE RATS
J TANAKA; A USHIGOME; M MATSUDA; H SAITO
NEUROSCIENCE LETTERS, May 1995, [Reviewed] - CCK ACTIVATES EXCITATORY VENTRAL TEGMENTAL PATHWAYS TO THE POSTERIOR NUCLEUS-ACCUMBENS
J TANAKA; K KARIYA; A USHIGOME; M MATSUDA; M NOMURA
NEUROREPORT, Dec. 1994, [Reviewed]
MISC
- Involvement of GABA receptor mechanisms in the modulation of noradrenaline release in the rat median preoptic area to osmotic stimulation
Ushigome Akihiko; Matsushita Koji; Miyakubo Hiroko; Tambara Kanako; Hayashi Yasushi; Tanaka Junichi
Proceedings of Annual Meeting of the Physiological Society of Japan, 2008
Microdialysis was employed to examine whether osmotic stimulation causes alterations in the release of noradrenaline (NA) in the median preoptic nucleus (MnPO), and whether γ-aminobutyric acid (GABA) receptor mechanisms are involved in the modulation of the stimulus-induced alteration in the NA release in the MnPO. In urethane-anesthetized male rats, intraperitoneal injection of hypertonic saline (0.3 M NaCl, 1 ml) significantly decreased dialysate NA concentration in the MnPO area. The decrease in the NA level elicited by the osmotic stimulation was significantly attenuated by perfusion with phaclofen (10 μM), a GABA<SUB>B</SUB> receptor antagonist, but not by perfusion with bicuculline (10 μM), a GABA<SUB>A</SUB> receptor antagonist, through a microdialysis probe. Microinjection of the local anesthetic lidocaine (2%, 0.2 µl) into the organum vasclosum of the lamina terminalis (OVLT) significantly attenuated the decrease in the NA release in the MnPO area. We conclude, in conjunction with the previous findings that the OVLT exerts inhibitory influences on the NA release in the MnPO area through GABA<SUB>B</SUB> receptor mechanisms, that the decrease in the NA release in the MnPO area elicited by the osmotic stimulation may be mediated in part by GABAergic inputs from the OVLT. <b>[J Physiol Sci. 2008;58 Suppl:S157]</b>, PHYSIOLOGICAL SOCIETY OF JAPAN - Involvement of serotonergic systems in the subfornical organ in the control of sodium and water intake in rats
Ushigome Akihiko; Tanaka Junichi; Fujisawa Shigeko; Kariya Katsuhide; Nomura Masahiko
Proceedings of Annual Meeting of the Physiological Society of Japan, 2004
The subfornical organ (SFO) is involved in the modulation of sodium and water intake in the rat. To clarify whether serotonergic mechanisms in the SFO participate in the modulatory system, experiments were carried out to investigate the effects of sodium and water intake on serotonin (5-hydroxytryptamine, 5-HT) release in the subfornical organ (SFO) in freely moving rats. The intake of 0.3 M NaCl and water was induced by subcutaneous injections of the diuretic furosemide (FURO, 10 mg/kg) and the angiotensin converting enzyme inhibitor captopril (CAP, 5 mg/kg), and extracellular concentrations of 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) in the region of the SFO were measured using intracerebral microdialysis techniques. The combined treatment with FURO and CAP produced significant decreases in the 5-HT and 5-HIAA levels in the SFO area. The 0.3 M NaCl and water intake caused by the treatment significantly increased the 5-HT and 5-HIAA concentrations in the SFO area compared with the basal levels. No significant changes in the 5-HT and 5-HIAA levels elicited by either the FURO and CAP treatment or water and NaCl intake were observed in the sites away from the SFO. These results suggest that the serotonergic mechanism in the SFO area may be important for the control of sodium appetite and thirst. <b>[Jpn J Physiol 54 Suppl:S205 (2004)]</b>, PHYSIOLOGICAL SOCIETY OF JAPAN - Attenuated salt appetite in spontaneously hypertensive rats following local administration of an angiotensin II antagonist into the median preoptic area
Tanaka Junichi; Muguruma Ikue; Ushigome Akihiko; Mori Kanae; Shimamune Satoru; Matsuda Michihiko
Research bulletin of natural sciences, Naruto University of Education, 1996
Naruto University of Education - Serotonergic pathways from the midbrain raphe system to the subfornical organ in rats
Tanaka junichi; Ushigome Akihiko; Yano Jinichi; Matsuda Michihiko
Research bulletin of natural sciences, Naruto University of Education, 1995
Naruto University of Education
Books and other publications
Lectures, oral presentations, etc.
- 保護者が考える自閉症のある子どもの感覚面の特性
25 Aug. 2023 - 重複障がいのある子どもたちへの多感覚を活用した教育・保育活動の活動性
24 Nov. 2018 - Participation of glutamatergic receptor systems in the median preoptic nucleus in the drinking response induced by angiotensin II activation of the subfornical organ in the rat
USHIGOME AKIHIKO
26 Jul. 2018 - 保育所、幼稚園におけるアプローチカリキュラムと小学校におけるスタートカリキュラムの検討
28 Aug. 2010 - 脳科学から見た発達障害
29 Jul. 2010 - 障害と脳
21 Jul. 2010 - 発達障害と脳の関係
01 Jul. 2010
Research Themes
- 障害のある外国人幼児児童生徒の多感覚を活用した発達支援モデルの開発
01 Apr. 2022 - 31 Mar. 2026 - 発達障害支援における生理学的指標評価に基づく支援モデルの構築
01 Apr. 2022 - 31 Mar. 2025 - 困難を抱える子どもを包摂する多重感覚発達支援環境の実証的研究：日英米の環境比較
01 Apr. 2019 - 31 Mar. 2023 - Empirical research of sensory activities for lifelong learning support in multiple disabilities: Japanese-English comparative study
Grant-in-Aid for Scientific Research (C)
Naruto University of Education
01 Apr. 2018 - 31 Mar. 2022
Lifelong learning support for persons with disabilities is required in the community. In particular, children with multiple disabilities are in a situation where it is difficult to promote learning support through local residents and volunteers due to the need for assistance in daily life caused by the central nervous system. In this study, we elucidate a part of the pathway from the sensory mechanism involved in the regulation of body water content to the triggering behavior for water maintenance, thereby supporting people with multiple disabilities to live. In the UK, activities that take advantage of not only developmental age but also academic perspectives such as history, such as activities with Roman motifs and Shakespeare drama literature, are carried out.
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