Takahiro Toda
| Faculty of Pharmaceutical Sciences,Department of Pharmaceutical Sciences | Lecturer |
Last Updated :2026/03/31
■Research activity information
Paper
- Mechanistic analysis of bladder cancer suppression by brassicasterol in a rat model of N-butyl-N-(4-hydroxybutyl)nitrosamine-induced bladder cancer
Nobutomo Ikarashi; Tetsuya Ono; Motohiro Hoshino; Takahiro Toda; Yasuharu Yazawa; Kiyoshi Sugiyama
Traditional and Kampo Medicine, Aug. 2021, [Reviewed] - A Mechanism by which Ergosterol Inhibits the Promotion of Bladder Carcinogenesis in Rats.
Nobutomo Ikarashi; Motohiro Hoshino; Tetsuya Ono; Takahiro Toda; Yasuharu Yazawa; Kiyoshi Sugiyama
Biomedicines, 27 Jun. 2020, [Reviewed]
We previously showed that ergosterol has an inhibitory effect on bladder carcinogenesis. In this study, we aimed to elucidate the molecular mechanism by which ergosterol inhibits bladder carcinogenesis using a rat model of N-butyl-N-(4-hydroxybutyl)nitrosamine-induced bladder cancer. The messenger ribonucleic acid (mRNA) expression level of the cell cycle-related gene cyclin D1 and inflammation-related gene cyclooxygenase-2 in bladder epithelial cells was significantly increased in the carcinogenesis group compared with the control group. In contrast, in ergosterol-treated rats, these increases were significantly suppressed. Ergosterol did not affect the plasma testosterone concentration or the binding of dihydrotestosterone to androgen receptor (AR). The mRNA expression levels of 5α-reductase type 2 and AR were higher in the carcinogenesis group than in the control group but were significantly decreased by ergosterol administration. These results suggest that ergosterol inhibits bladder carcinogenesis by modulating various aspects of the cell cycle, inflammation-related signaling, and androgen signaling. Future clinical application of the preventive effect of ergosterol on bladder carcinogenesis is expected. - Protective Effects of Duloxetine against Cerebral Ischemia-Reperfusion Injury via Transient Receptor Potential Melastatin 2 Inhibition.
Toda T; Yamamoto S; Umehara N; Mori Y; Wakamori M; Shimizu S
The Journal of pharmacology and experimental therapeutics, Feb. 2019, [Reviewed]
Activation of transient receptor potential melastatin 2 (TRPM2), an oxidative stress-sensitive Ca2+-permeable channel, contributes to the aggravation of cerebral ischemia-reperfusion (CIR) injury. Recent studies indicated that treatment with the antidepressant duloxetine for 24 hours (long term) attenuates TRPM2 activation in response to oxidative stress in neuronal cells. To examine the direct effects of antidepressants on TRPM2 activation, we examined their short-term (0-30 minutes) treatment effects on H2O2-induced TRPM2 activation in TRPM2-expressing human embryonic kidney 293 cells using the Ca2+ indicator fura-2. Duloxetine exerted the strongest inhibitory effects on TRPM2 activation among the seven antidepressants tested. These inhibitory effects appeared to be due to the inhibition of H2O2-induced TRPM2 activation via an open-channel blocking-like mechanism, because duloxetine reduced the sustained phase but not the initial phase of increases in intracellular Ca2+ concentrations. In a whole-cell patch-clamp study, duloxetine reduced the TRPM2-mediated inward current during the channel opening state. We also examined the effects of duloxetine in a mouse model of CIR injury. The administration of duloxetine to wild-type mice attenuated CIR injury, similar to that in Trpm2 knockout (KO) mice. The administration of duloxetine did not reduce CIR injury further in Trpm2 KO mice, suggesting that it exerts neuroprotective effects against CIR injury by inhibiting TRPM2 activation. Regarding drug repositioning, duloxetine may be a useful drug in reperfusion therapy for ischemic stroke because it has already been used clinically in therapeutics for several disorders, including depression. - Anti-Hypertensive Effects of Acacia Polyphenol in Spontaneously Hypertensive Rats
Nobutomo Ikarashi; Takahiro Toda; Yusuke Hatakeyama; Yoshiki Kusunoki; Risako Kon; Nanaho Mizukami; Miho Kaneko; Sosuke Ogawa; Kiyoshi Sugiyama
International Journal of Molecular Sciences, 01 Mar. 2018, [Reviewed] - Tyrphostin AG-related compounds attenuate H2O2-induced TRPM2-dependent and -independent cellular responses
Shinichiro Yamamoto; Takahiro Toda; Ryo Yonezawa; Takaharu Negoro; Shunichi Shimizu
JOURNAL OF PHARMACOLOGICAL SCIENCES, May 2017, [Reviewed] - Inhibitory effects of Tyrphostin AG-related compounds on oxidative stress-sensitive transient receptor potential channel activation
Takahiro Toda; Shinichiro Yamamoto; Ryo Yonezawa; Yasuo Mori; Shunichi Shimizu
EUROPEAN JOURNAL OF PHARMACOLOGY, Sep. 2016, [Reviewed] - TRPM2 channels in alveolar epithelial cells mediate bleomycin-induced lung inflammation
Ryo Yonezawa; Shinichiro Yamamoto; Miki Takenaka; Yukiko Kage; Takaharu Negoro; Takahiro Toda; Masayuki Ohbayashi; Tomohiro Numata; Yasuko Nakano; Toshinori Yamamoto; Yasuo Mori; Masakazu Ishii; Shunichi Shimizu
FREE RADICAL BIOLOGY AND MEDICINE, Jan. 2016, [Reviewed] - Serotonergic mechanisms are involved in antidepressant-like effects of bisbenzylisoquinolines liensinine and its analogs isolated from the embryo of Nelumbo nuciferaGaertner seeds in mice
Yumi Sugimoto; Katsumi Nishimura; Atsuko Itoh; Takao Tanahashi; Hiroshi Nakajima; Hideo Oshiro; Shujian Sun; Takahiro Toda; Jun Yamada
JOURNAL OF PHARMACY AND PHARMACOLOGY, Dec. 2015, [Reviewed] - Sensitization of H2O2-induced TRPM2 activation and subsequent interleukin-8 (CXCL8) production by intracellular Fe2+ in human monocytic U937 cells
Shunichi Shimizu; Ryo Yonezawa; Takaharu Negoro; Shinichiro Yamamoto; Tomohiro Numata; Masakazu Ishii; Yasuo Mori; Takahiro Toda
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, Nov. 2015, [Reviewed] - Inhibitory effects of AG490 on H2O2-induced TRPM2-mediated Ca2+ entry
Shunichi Shimizu; Ryo Yonezawa; Tamio Hagiwara; Takashi Yoshida; Nobuaki Takahashi; Satoshi Hamano; Takaharu Negoro; Takahiro Toda; Minoru Wakamori; Yasuo Mori; Masakazu Ishii
EUROPEAN JOURNAL OF PHARMACOLOGY, Nov. 2014, [Reviewed] - Gastrectomy Increases the Expression of Hepatic Cytochrome P450 3A by Increasing Lithocholic Acid-Producing Enteric Bacteria in Mice
Makoto Ishii; Takahiro Toda; Nobutomo Ikarashi; Yoshiki Kusunoki; Risako Kon; Wataru Ochiai; Yoshiaki Machida; Kiyoshi Sugiyama
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Feb. 2014, [Reviewed] - Total gastrectomy may result in reduced drug effectiveness due to an increase in the expression of the drug-metabolizing enzyme Cytochrome P450, in the liver
Makoto Ishii; Takahiro Toda; Nobutomo Ikarashi; Yoshiki Kusunoki; Risako Kon; Wataru Ochiai; Yoshiaki Machida; Kiyoshi Sugiyama
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, Jan. 2014, [Reviewed] - A Novel Aromatic Carboxylic Acid Inactivates Luciferase by Acylation of an Enzymatically Active Regulatory Lysine Residue
Madoka Nakagomi; Nobuko Fujimaki; Ai Ito; Takahiro Toda; Hiroshi Fukasawa; Koichi Shudo; Ryoichi Tomita
PLoS ONE, 16 Sep. 2013, [Reviewed] - Synthesis of Am80 (Tamibarotene) Prodrug Candidates, Congeners and Metabolites
Hideaki Muratake; Yohei Amano; Takahiro Toda; Kiyoshi Sugiyama; Koichi Shudo
CHEMICAL & PHARMACEUTICAL BULLETIN, Aug. 2013, [Reviewed] - Consumption of a High-Fat Diet during Pregnancy Changes the Expression of Cytochrome P450 in the Livers of Infant Male Mice
Masataka Tajima; Nobutomo Ikarashi; Takehiro Okaniwa; Yukari Imahori; Kanako Saruta; Takahiro Toda; Makoto Ishii; Yoshikazu Tanaka; Yoshiaki Machida; Wataru Ochiai; Harumi Yamada; Kiyoshi Sugiyama
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Apr. 2013, [Reviewed] - Different Diets Cause Alterations in the Enteric Environment and Trigger Changes in the Expression of Hepatic Cytochrome P450 3A, a Drug-Metabolizing Enzyme
Masataka Tajima; Nobutomo Ikarashi; Shintaro Igeta; Takahiro Toda; Makoto Ishii; Yoshikazu Tanaka; Yoshiaki Machida; Wataru Ochiai; Harumi Yamada; Kiyoshi Sugiyama
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Apr. 2013, [Reviewed] - (R)- and (S)-4-Amino-3-(trimethylsilyl)methylbutanoic acids ameliorate neuropathic pain without central nervous system-related side effects
Hideaki Muratake; Ai Ito; Takahiro Toda; Hideyuki Suzuki; Hiroshi Fukasawa; Makoto Tsuda; Kazuhide Inoue; Kiyoshi Sugiyama; Koichi Shudo
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Dec. 2012, [Reviewed] - Consumption of a high-fat diet during pregnancy decreases the activity of cytochrome P450 3a in the livers of offspring
Masataka Tajima; Nobutomo Ikarashi; Yukari Imahori; Takehiro Okaniwa; Kanako Saruta; Makoto Ishii; Yoshiki Kusunoki; Risako Kon; Takahiro Toda; Wataru Ochiai; Harumi Yamada; Kiyoshi Sugiyama
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, Aug. 2012, [Reviewed] - Inhibition of Aquaporin-3 Water Channel in the Colon Induces Diarrhea
Nobutomo Ikarashi; Risako Kon; Tomohiko Iizasa; Noriko Suzuki; Reiko Hiruma; Kiyomi Suenaga; Takahiro Toda; Makoto Ishii; Motohiro Hoshino; Wataru Ochiai; Kiyoshi Sugiyama
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Jun. 2012, [Reviewed] - Effects of Intestinal Flora on the Expression of Cytochrome P450 3A in the Liver
Makoto Ishii; Takahiro Toda; Nobutomo Ikarashi; Wataru Ochiai; Kiyoshi Sugiyama
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Mar. 2012, [Reviewed] - Effect of Conclevan on Endurance Capacity in Mice
Nobutomo Ikarashi; Yoko Fukazawa; Takahiro Toda; Makoto Ishii; Wataru Ochiai; Masatoshi Usukura; Kiyoshi Sugiyama
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Feb. 2012, [Reviewed] - Inhibition of Preadipocyte Differentiation and Lipid Accumulation by Orengedokuto Treatment of 3T3-L1 Cultures
Nobutomo Ikarashi; Masataka Tajima; Kunihiro Suzuki; Takahiro Toda; Kiyomi Ito; Wataru Ochiai; Kiyoshi Sugiyama
PHYTOTHERAPY RESEARCH, Jan. 2012, [Reviewed] - The concomitant use of an osmotic laxative, magnesium sulphate, and a stimulant laxative, bisacodyl, does not enhance the laxative effect
Nobutomo Ikarashi; Ayako Mimura; Risako Kon; Tomohiko Iizasa; Midori Omodaka; Chika Nagoya; Makoto Ishii; Takahiro Toda; Wataru Ochiai; Kiyoshi Sugiyama
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, Jan. 2012, [Reviewed] - Gypsum fibrosum and its major component CaSO4 increase cutaneous aquaporin-3 expression levels
Nobutomo Ikarashi; Naoki Ogiue; Eri Toyoda; Risako Kon; Makoto Ishii; Takahiro Toda; Takashi Aburada; Wataru Ochiai; Kiyoshi Sugiyama
JOURNAL OF ETHNOPHARMACOLOGY, Jan. 2012, [Reviewed] - Inhibitory Effect of Polyphenol-Rich Fraction from the Bark of Acacia mearnsii on Itching Associated with Allergic Dermatitis
Nobutomo Ikarashi; Wataru Sato; Takahiro Toda; Makoto Ishii; Wataru Ochiai; Kiyoshi Sugiyama
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2012, [Reviewed] - The laxative effect of bisacodyl is attributable to decreased aquaporin-3 expression in the colon induced by increased PGE(2) secretion from macrophages
Nobutomo Ikarashi; Kohta Baba; Takashi Ushiki; Risako Kon; Ayako Mimura; Takahiro Toda; Makoto Ishii; Wataru Ochiai; Kiyoshi Sugiyama
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, Nov. 2011, [Reviewed] - Byakkokaninjinto Prevents Body Water Loss by Increasing the Expression of Kidney Aquaporin-2 and Skin Aquaporin-3 in KKAy Mice
Takashi Aburada; Nobutomo Ikarashi; Mai Kagami; Yuhei Ichikawa; Megumi Sugitani; Ayaka Maniwa; Harumi Ueda; Takahiro Toda; Kiyomi Ito; Wataru Ochiai; Ryo Matsushita; Ken-ichi Miyamoto; Kiyoshi Sugiyama
PHYTOTHERAPY RESEARCH, Jun. 2011, [Reviewed] - Changes in the pharmacokinetics of digoxin in polyuria in streptozotocin-induced diabetic mice and lithium carbonate-treated mice
Nobutomo Ikarashi; Mai Kagami; Yasushi Kobayashi; Makoto Ishii; Takahiro Toda; Wataru Ochiai; Kiyoshi Sugiyama
XENOBIOTICA, Jun. 2011, [Reviewed] - Effects of Magnesium Sulphate Administration on Aquaporin 3 in Rat Gastrointestinal Tract
Nobutomo Ikarashi; Takashi Ushiki; Toshihide Mochizuki; Takahiro Toda; Toshiyuki Kudo; Kohta Baba; Makoto Ishii; Kiyomi Ito; Wataru Ochiai; Kiyoshi Sugiyama
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Feb. 2011, [Reviewed] - A mechanism by which the osmotic laxative magnesium sulphate increases the intestinal aquaporin 3 expression in HT-29 cells
Nobutomo Ikarashi; Toshihide Mochiduki; Ayaka Takasaki; Takashi Ushiki; Kohta Baba; Makoto Ishii; Toshiyuki Kudo; Kiyomi Ito; Takahiro Toda; Wataru Ochiai; Kiyoshi Sugiyama
LIFE SCIENCES, Jan. 2011, [Reviewed] - Anti-Obesity and Anti-Diabetic Effects of Acacia Polyphenol in Obese Diabetic KKAy Mice Fed High-Fat Diet
Nobutomo Ikarashi; Takahiro Toda; Takehiro Okaniwa; Kiyomi Ito; Wataru Ochiai; Kiyoshi Sugiyama
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2011, [Reviewed] - Increases in the Expression Levels of Aquaporin-2 and Aquaporin-3 in the Renal Collecting Tubules Alleviate Dehydration Associated with Polyuria in Diabetes Mellitus
Masako Satake; Nobutomo Ikarashi; Mai Kagami; Naoki Ogiue; Takahiro Toda; Yasushi Kobayashi; Wataru Ochiai; Kiyoshi Sugiyama
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Dec. 2010, [Reviewed] - The role of renal aquaporin 2 in the alleviation of dehydration associated with diabetic polyuria in KKAy mice
Masako Satake; Nobutomo Ikarashi; Yuhei Ichikawa; Ayaka Maniwa; Takahiro Toda; Kiyomi Ito; Wataru Ochiai; Kiyoshi Sugiyama
LIFE SCIENCES, Oct. 2010, [Reviewed] - Differences in the pharmacokinetics of Cyp3a substrates in TSOD and streptozotocin-induced diabetic mice
T. Kudo; T. Toda; T. Ushiki; K. Ohi; N. Ikarashi; W. Ochiai; K. Sugiyama
XENOBIOTICA, Apr. 2010, [Reviewed] - Altered expression of CYP in TSOD mice: a model of type 2 diabetes and obesity.
Kudo T; Shimada T; Toda T; Igeta S; Suzuki W; Ikarashi N; Ochiai W; Ito K; Aburada M; Sugiyama K
Xenobiotica., Dec. 2009, [Reviewed] - Antibiotics Suppress Cyp3a in the Mouse Liver by Reducing Lithocholic Acid-producing Intestinal Flora
Takahiro Toda; Kanna Ohi; Toshiyuki Kudo; Tomoyuki Yoshida; Nobutomo Ikarashi; Kiyomi Ito; Kiyoshi Sugiyama
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, May 2009, [Reviewed] - Intestinal flora induces the expression of Cyp3a in the liver.
TODA TAKAHIRO; SAITO N; FUJIMOTO A; IKARASHI N; ITO K; YAMAMOTO MASAHIRO; ISHIGE ATSUSHI; WATANABE KENJI
Xenobiotica, 2009, [Reviewed] - Effect of Hydrocotarnine on Cytochrome P450 and P-glycoprotein
Kiyomi Ito; Yu Kubota; Takahiro Toda; Satoshi Suto; Nobutomo Ikarashi; Kiyoshi Sugiyama
DRUG METABOLISM AND PHARMACOKINETICS, 2009, [Reviewed] - Ciprofloxacin Suppresses Cyp3a in Mouse Liver by Reducing Lithocholic Acid-producing Intestinal Flora
Takahiro Toda; Kanna Ohi; Toshiyuki Kudo; Tomoyuki Yoshida; Nobutomo Ikarashi; Kiyomi Ito; Kiyoshi Sugiyama
DRUG METABOLISM AND PHARMACOKINETICS, 2009, [Reviewed] - 漢方専門外来受診患者における漢方薬服用に関する実態調査(1) 漢方薬と西洋薬の併用
五十嵐 信智; 志村 彩香; 竹澤 崇; 武藤 麻美; 戸田 雄大; 伊藤 清美; 木村 孝良; 秋葉 哲生; 入江 祥史; 渡辺 賀子; 福澤 素子; 石井 弘一; 渡辺 賢治; 杉山 清
医療薬学, Apr. 2007, [Reviewed] - Juzentaihoto reduces post-partial hepatectomy hyperammonemia by stabilizing intestinal microbiota
Yoshihiro Imazu; Kenji Tsuiji; Takahiro Toda; Atsushi Ishige; Kiyoshi Sugiyama; Yoshimi Benno; Kenji Watanabe; Masaki Kitajima
Journal of Traditional Medicines, 2006, [Reviewed]
MISC
- Duloxetineによる活性酸素感受性Ca2+透過性チャネルTRPM2の活性化抑制
Mar. 2016 - Tyrphostin AG化合物による活性酸素感受性Ca2+透過性チャネルTRPM2の活性化抑制
Mar. 2015 - アカシア樹皮ポリフェノールの抗高血圧作用
Jul. 2013 - 妊娠期の高脂肪食摂取は、雄の仔マウスの肝臓において各種Cytochorome P450分子種の発現量を変動させる
Mar. 2013 - セッコウの皮膚アクアポリン3発現増加メカニズムの解明
Aug. 2012 - アカシア樹皮ポリフェノールはアトピー性皮膚炎を改善する
Nov. 2011 - 漢方薬含有鉱物セッコウは皮膚アクアポリン3の発現を増加する
Nov. 2011 - 二妙散の痛風予防効果に関する薬理学的研究 尿酸トランスポーターの発現に及ぼす影響
Nov. 2011 - ES細胞から肝細胞分化誘導過程におけるCytochrome P450分子種の役割
Sep. 2011 - アカシア樹皮ポリフェノールの抗高血圧作用とそのメカニズム
Sep. 2011 - アトピー性皮膚炎に対するアカシア樹皮ポリフェノールの抑制効果
Sep. 2011 - アカシア樹皮ポリフェノールのアトピー性皮膚炎改善効果
Aug. 2011 - 白虎加人参湯含有鉱物セッコウの皮膚アクアポリン3の発現に及ぼす影響
Aug. 2011 - 糖尿病に伴う多尿時における腎排泄型薬物ジゴキシンの体内動態の変動
Apr. 2011 - 糖尿病時における腎臓aquaporinの発現増加意義の解明
Apr. 2011 - 医薬品「コンクレバン」の抗疲労効果
Mar. 2011 - 安全・安心な社会を支える薬学研究の新展開 若手の視点からの提言 肝臓のチトクロムP450 3Aの発現に及ぼす腸内細菌の影響
Mar. 2011 - 腸内細菌の肝臓および小腸のトランスポーターの発現に及ぼす影響
Dec. 2010 - 新規2型糖尿病モデルTSODマウスの肝臓における薬物トランスポーターの発現特性
Dec. 2010 - 胃切除モデルマウスの肝臓において薬物代謝酵素Cyp3aの発現量が増加する
Dec. 2010 - リファンピシンはDSS誘発潰瘍性大腸炎を軽減する
Dec. 2010 - DSS誘発潰瘍性大腸炎モデルマウスに対するリファンピシンの効果
Oct. 2010 - 高脂肪食誘導性肥満・糖尿病KKAyマウスに対するアカシア樹皮ポリフェノールの作用 骨格筋・肝臓・白色脂肪組織に及ぼす影響
Apr. 2010 - 糖尿病時における腎臓AQP2の発現増加と尿量との関係
Mar. 2010 - 硫酸マグネシウムの瀉下作用における腸管アクアポリンの役割の検討
Mar. 2010 - 抗菌薬投与により腸内細菌が減少すると肝臓のCyp3aも減少する
Mar. 2010 - 胃切除モデルマウスの肝臓における薬物代謝酵素の発現変動
Mar. 2010 - DSS誘発潰瘍性大腸炎モデルマウスに対するリファンピシンの効果
Mar. 2010 - 1型糖尿病モデルSTZマウスおよび2型糖尿病モデルTSODマウスの肝臓におけるCyp3aの発現および活性の比較
Mar. 2010 - 抑肝散の薬物動態学的研究
Mar. 2010 - 高脂肪食およびMF負荷マウスの肝臓および小腸におけるCyp3aの発現変動
Mar. 2010 - 肥満型糖尿病モデルTSODマウスの肝臓におけるCYPの発現変動
Sep. 2009 - 硫酸マグネシウムによる腸管アクアポリンの発現変化
Sep. 2009 - アカシア樹皮ポリフェノールの肥満抑制作用メカニズムの検討
Sep. 2009 - 腸内細菌はCyp3aの発現を制御している 抗生物質投与によるCyp3aの発現低下
Aug. 2009 - 硫酸マグネシウムによる腸管アクアポリンの発現変化メカニズムの検討
Mar. 2009 - 糖尿病の病態に起因する腎臓アクアポリンの発現変化
Mar. 2009 - Streptozotocin誘導糖尿病モデルマウスにおけるCyp3a発現変動メカニズムの検討
Mar. 2009 - 出生前後におけるCyp3a11発現変動メカニズムの検討
Mar. 2009 - 白虎加人参湯による唾液腺および皮膚におけるアクアポリンの発現変化
Sep. 2008 - 緑茶微粉末加工食品フォースSODによるシスプラチン副作用に対するメカニズム
Sep. 2008 - 緑茶微粉末加工食品フォースSODによるシスプラチン副作用軽減効果
Mar. 2008 - 白虎加人参湯による唾液腺および皮膚におけるアクアポリンの発現変化
Mar. 2008 - 硫酸マグネシウムによる腸管アクアポリンの発現変化
Mar. 2008 - 潰瘍性大腸炎モデルマウスの肝臓におけるCyp3aおよび炎症性サイトカインの発現変化
Mar. 2008 - 2型糖尿病モデルマウスへの高脂肪食負荷によるCYPおよびP-gpの発現変化
Mar. 2008 - 出生および加齢によるCYP発現量の変化
Mar. 2008 - 肝臓におけるCYPの発現に及ぼす腸内細菌の影響
Mar. 2008 - 肥満型糖尿病モデルTSODマウスにおけるCYPの発現変動
Mar. 2008 - 患者の健康食品使用状況に関する実態調査
Oct. 2007 - 薬物代謝酵素の発現に及ぼす腸内細菌の影響とそのメカニズムの解明
Mar. 2007 - Cyp3a及びP-gpの活性に及ぼす漢方薬連続投与の影響
Mar. 2007 - 健康食品に関する意識調査
Mar. 2007 - DSS誘発潰瘍性大腸炎モデルマウスにおけるCyp3aの発現変化
Mar. 2007 - CYP4B1及びCYP2E1の発現に及ぼすエルゴステロールの影響
Mar. 2007 - 3T3-L1脂肪前駆細胞の分化および成熟脂肪細胞の脂肪蓄積に及ぼすberberineの効果
Mar. 2007 - 2型糖尿病の進行による多尿に伴うAQPの発現変化
Mar. 2007 - 白虎加人参湯による腎臓のアクアポリン発現変化
Mar. 2007 - CYPおよびP-gpに及ぼすヒドロコタルニンの影響
Mar. 2007 - 2型糖尿病の進行に伴う腎臓におけるAQPの発現変化とその機能
Aug. 2006 - Berberineによる抗肥満作用の検討
Aug. 2006 - 腸内細菌による薬物代謝酵素の発現変動
Aug. 2006 - 利胆薬併用によるグリチルリチンの体内動態の変化
Aug. 2006 - 薬物代謝酵素の発現に及ぼす腸内細菌の影響
Mar. 2006 - 漢方クリニックにおける漢方薬の使用状況に関する実態調査
Mar. 2006 - 漢方薬は腎臓におけるアクアポリンの発現に影響を及ぼすか?
Mar. 2006 - KK-AyマウスにおけるPPARγ抑制成分berberineの抗肥満作用
Mar. 2006 - 漢方薬と西洋薬との併用に伴う問題点の解析
Apr. 2005 - CYPおよびP-gp関連遺伝子の発現に及ぼす腸内細菌の影響
Mar. 2005
Research Themes
- The mechanisms of brain injury caused by cerebral ischemia/reperfusion via TRPM2 activation
Grant-in-Aid for Scientific Research (C)
Teikyo Heisei University
01 Apr. 2021 - 31 Mar. 2024 - Localization and role of TRPM2 channel in the heart
Grant-in-Aid for Scientific Research (C)
Teikyo Heisei University
01 Apr. 2015 - 31 Mar. 2018
TRPM2 is an oxidative stress-sensitive Ca2+-permeable channel. In this study, we examined the localization and the function of TRPM2 channels in the heart from mouse. In the heart, TRPM2 mRNA was expressed in right atrium, especially, around sinus venarum cavarum. In fact, the cells from around sinus venarum cavarum showed TRPM2 channel-dependent current induced by ADP-ribose. In the perfusion model of isolated heart, we found that TRPM2 channels are implicated in the increases of heart rate by the stimulation of adrenaline beta-1 receptor and the rising of temperature. Furthermore, we found that TRPM2 channel were also implicated in the induction of arrhythmia during cardiac ischemia-reperfusion.
