Quadripulse transcranial magnetic stimulation inducing long-term depression in healthy subjects may increase seizure risk in some patients with intractable epilepsy.
Setsu Nakatani-Enomoto; Ritstuko Hanajima; Masashi Hamada; Hideyuki Matsumoto; Yasuo Terao; Stefan Jun Groiss; Takenobu Murakami; Mitsunari Abe; Hiroyuki Enomoto; Kensuke Kawai; Rumiko Kan; Shin-Ichi Niwa; Hirooki Yabe; Yoshikazu Ugawa
Clinical neurophysiology practice, 2023
OBJECTIVE: This study aimed to assess the efficacy and safety of quadripulse transcranial magnetic stimulation-50 (QPS-50) in patients with intractable epilepsy. METHODS: Four patients were included in the study. QPS-50, which induces long-term depression in healthy subjects, was administered for 30 min on a weekly basis for 12 weeks. Patients' clinical symptoms and physiological parameters were evaluated before, during, and after the repeated QPS-50 period. We performed two control experiments: the effect in MEP (Motor evoked potential) size after a single QPS-50 session with a round coil in nine healthy volunteers, and a follow-up study of physiological parameters by repeated QPS-50 sessions in four other healthy participants. RESULTS: Motor threshold (MT) decreased during the repeated QPS-50 sessions in all patients. Epileptic symptoms worsened in two patients, whereas no clinical worsening was observed in the other two patients. In contrast, MT remained unaffected for 12 weeks in all healthy volunteers. CONCLUSIONS: QPS-50 may not be effective as a treatment for intractable epilepsy. SIGNIFICANCE: In intractable epilepsy patients, administering repeated QPS-50 may paradoxically render the motor cortex more excitable, probably because of abnormal inhibitory control within the epileptic cortex. The possibility of clinical aggravation should be seriously considered when treating intractable epilepsy patients with non-invasive stimulation methods.

Hemophagocytic Lymphohistiocytosis Associated with Disseminated Nontuberculous Mycobacterial Infection in a Patient with Mesenteric Panniculitis.
Yuya Fujita; Haruki Matsumoto; Tomoyuki Asano; Shuzo Sato; Makiko Yashiro-Furuya; Naoki Matsuoka; Jumpei Temmoku; Setsu Nakatani-Enomoto; Satoshi Kimura; Kenta Hoshi; Manabu Uematsu; Hiroshi Watanabe; Kiyoshi Migita
The Tohoku journal of experimental medicine, Feb. 2021
Mesenteric panniculitis is a chronic inflammatory disease characterized by non-specific inflammation of the adipose tissue in the mesentery. Hemophagocytic lymphohistiocytosis is a life-threating disease associated with aberrant macrophage overactivation, in which infections can be a leading cause in immunocompromised hosts. Here, we report a rare case of mesenteric panniculitis and hemophagocytic lymphohistiocytosis complicated by disseminated Mycobacterium intracellulare. A 71-year-old male with mesenteric panniculitis was admitted to our hospital for fever and pancytopenia. He was treated with oral prednisolone (15 mg/day) and cyclosporin A (150 mg/day) at presentation. Physical and laboratory examinations revealed disseminated infection with nontuberculous mycobacteria; Mycobacterium intracellulare was detected in cultures of cerebrospinal fluid, blood, sputum, and gastric fluid. Patient signs and symptoms fulfilled the five criteria for a diagnosis of hemophagocytic lymphohistiocytosis, including fever, cytopenia, hemophagocytosis, hyperferritinemia, and high soluble interleukin-2 receptor levels. Therefore, the diagnosis of nontuberculous mycobacteria-associated hemophagocytic lymphohistiocytosis was established. An anti-mycobacterial chemotherapy including chloramphenicol (800 mg/day), rifampin (450 mg/day) and ethambutol (750 mg/day) together with streptomycin (750 mg twice per week) was initiated at 30 days after admission; maintenance doses of prednisolone were increased to 60 mg/day. Fever and pancytopenia improved in response to anti-mycobacterial chemotherapy. The present case suggests that mesenteric panniculitis could be complicated with hemophagocytic lymphohistiocytosis caused by immunosuppressive therapy-associated infections as well as underlying disease activity. In conclusion, the possibility of disseminated nontuberculous mycobacteria infection with hemophagocytic lymphohistiocytosis should be considered if unexplained fever or hematological dyscrasia were presented in patients of mesenteric panniculitis.

Effects of electromagnetic fields from long-term evolution on awake electroencephalogram in healthy humans.
Setsu Nakatani-Enomoto; Madoka Yamazaki; Keisuke Nishiura; Hiroyuki Enomoto; Yoshikazu Ugawa
Neuroscience research, Jul. 2020
Mobile phones are indispensable for daily life, and the adverse effects of the electromagnetic field (EMF) emitted by mobile phones have been a great concern. We studied the effects of long-term evolution (LTE) -like EMF for 30 min on an awake electroencephalogram (EEG). Thirty-eight healthy volunteers, aged 20-36 years old, participated in this study. The maximum local SAR (specific absorption rate) averaged over 10-g mass was 2.0 W/kg. The EEG was recorded before and after real or sham exposures. The effects of exposure conditions (real or sham) and the recording time (before, during, and after exposure) on each EEG power spectrum of θ, α, and β frequency ranges were analyzed. The θ and α band waves were enhanced after both exposure conditions. These results may be explained by the participants' drowsiness during the EEG recording in both exposures. We conclude that an LTE-like exposure for 30 min in this study showed no detectable harmful effects on awake EEGs in healthy humans.

IgG4-Related Disease Complicated by Brain Parenchymal Lesions Successfully Treated with Corticosteroid Therapy: A Case Report.
Jumpei Temmoku; Shuzo Sato; Haruki Matsumoto; Yuya Fujita; Erina Suzuki; Makiko Yashiro-Furuya; Naoki Matsuoka; Tomoyuki Asano; Eiichi Ito; Setsu Nakatani-Enomoto; Hiroko Kobayashi; Hiroshi Watanabe; Yuko Hashimoto; Kiyoshi Migita
The Tohoku journal of experimental medicine, Jul. 2020
Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is distinguished by the infiltration of IgG4-positive plasma cells in a variety of tissues and organs including the pancreas, salivary glands, retroperitoneal lesions, kidney, and lymph nodes with elevated serum IgG4 levels. Even so, central nervous system (CNS) lesions such as brain parenchymal lesions associated with IgG4-RD are scarce. So far, only six cases of IgG4-RD in relation with brain parenchymal lesions have been described, with its characteristics still being not clear. Here we have detailed a case of IgG4-RD with brain parenchymal lesions and reviewed previously-reported cases of IgG4-RD with brain parenchymal lesions. A 62-year-old Japanese male suffering from lung silicosis was admitted to our hospital for abdominal discomfort and altered consciousness. He has shown no major neurologic abnormalities except for drowsiness, urinary retention, and fecal incontinence. Brain magnetic resonance imaging has shown scattered hyperintense signals in the brain parenchyma. The serum IgG4 levels were elevated and systemic lymph nodes were enlarged. Biopsy from inguinal lymph nodes has shown massive infiltration of IgG4-positive plasma cells: the ratio of IgG4-positive/IgG-positive plasma cells was nearly 100%. Based on clinical courses, images, laboratory data, and pathological findings, a diagnosis of IgG4-RD that was complicated by brain parenchymal lesions and sacral nerve disturbance was confirmed. The patient was then given methylprednisolone pulse therapy (1g for 3 days) succeeding oral prednisolone (1 mg per body weight). The clinical and radiological improvements together with steroid therapy proposed IgG4-RD to be the cause of the lesions.

ペランパネルが磁気刺激を用いたpaired pulse stimulationに与える影響　　　　　　　　　　　　　　　
Nov. 2019

抗NMDAR脳炎における起立性低血圧をきたした脳幹病変の特異的形状(A Unique Shape of Brainstem Lesion that Caused Orthostatic Hypotension in Anti-NMDAR Encephalitis)
Murakami Takenobu; Nakatani-Enomoto Setsu; Enomoto Hiroyuki; Takahashi Yukitoshi; Ugawa Yoshikazu
Internal Medicine, Oct. 2019

ペランパネルが脳の可塑性に与える影響
Oct. 2019

多発脳神経麻痺で発症し進行性の筋力低下を呈した82歳女性例　　　　　　　　　　　　　　　
Jul. 2019

Frequency-dependent current perception threshold in healthy Japanese adults.
Nakatani-Enomoto S; Yamazaki M; Kamimura Y; Abe M; Asano K; Enomoto H; Wake K; Watanabe S; Ugawa Y
Bioelectromagnetics, Apr. 2019, [Reviewed]

Inflammatory myopathy with myasthenia gravis: Thymoma association and polymyositis pathology.
Naohiro Uchio; Kenichiro Taira; Chiseko Ikenaga; Masato Kadoya; Atsushi Unuma; Kenji Yoshida; Setsu Nakatani-Enomoto; Yuki Hatanaka; Yasuhisa Sakurai; Yasushi Shiio; Kenichi Kaida; Akatsuki Kubota; Tatsushi Toda; Jun Shimizu
Neurology(R) neuroimmunology & neuroinflammation, Mar. 2019
OBJECTIVE: To provide evidence that idiopathic inflammatory myopathy (IM) with myasthenia gravis (MG) frequently shows thymoma association and polymyositis (PM) pathology and shares clinicopathologic characteristics with IM induced by immune checkpoint inhibitors (ICIs). METHODS: We analyzed the clinicopathologic features of 10 patients with idiopathic IM and MG identified in 970 consecutive patients with biopsy-proven IM. RESULTS: Seven patients (70%) had thymoma. IM and MG were diagnosed with more than 5-year time difference in 6 thymomatous patients and within 1 year in 1 thymomatous and 3 nonthymomatous patients. Seven thymomatous patients showed rhabdomyolysis-like features with respiratory failure (4/7), dropped head (3/7), cardiac involvement (2/7), and positive anti-acetylcholine receptor (anti-AChR) and anti-titin antibodies (7/7 and 4/6, respectively) but rarely showed ocular symptoms (2/7) or decremental repetitive nerve stimulation (RNS) responses (1/7) at IM diagnosis. Three nonthymomatous patients showed acute cardiorespiratory failure with rhabdomyolysis-like features (1/3), positive anti-AChR and anti-titin antibodies (3/2 and 2/2, respectively), and fluctuating weakness of the skeletal muscle without ocular symptoms (3/3). Muscle pathology showed a PM pathology with infiltration of CD8-positive CD45RA-negative T-lymphocytes (9/9), scattered endomysial programmed cell death 1 (PD-1)-positive cells (9/9), and overexpression of programmed cell death ligand 1 (PD-L1) on the sarcolemma of muscle fibers around the infiltrating PD-1-positive cells (7/9). CONCLUSION: Rhabdomyolysis-like features, positive anti-AChR antibody without decremental RNS responses, and PD-L1 overexpression are possible characteristics shared by ICI-induced IM. Frequent thymoma association in patients with idiopathic IM and MG may suggest thymoma-related immunopathogenic mechanisms, including dysregulation of the immune checkpoint pathway.

A significant correlation between cauda equina conduction time and cerebrospinal fluid protein in chronic inflammatory demyelinating polyradiculoneuropathy.
Hideyuki Matsumoto; Ritsuko Hanajima; Yasuo Terao; Masashi Hamada; Yuichiro Shirota; Akihiro Yugeta; Setsu Nakatani-Enomoto; Hideji Hashida; Yoshikazu Ugawa
Journal of the neurological sciences, 15 Jan. 2018
We investigated the relationship between the involvement of the cauda equina in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and the increment of cerebrospinal fluid (CSF) protein. We measured cauda equina conduction time (CECT) in 14 CIDP patients using magnetic stimulation with a MATS coil. Statistical analysis revealed that CECT and CSF protein had a significant positive linear correlation. Conduction time of the peripheral nerve trunk, in contrast, had no significant linear correlation with CSF protein. We revealed that the involvement of the cauda equina and increment of CSF protein are closely related. In CIDP cases with elevated CSF protein, spinal nerves including the cauda equina are very likely involved.

Influence of radiofrequency-electromagnetic waves from 3rd-generation cellular phones on fertilization and embryo development in mice.
Satoshi Suzuki; Miho Okutsu; Ryota Suganuma; Hiromi Komiya; Setsu Nakatani-Enomoto; Shunsuke Kobayashi; Yoshikazu Ugawa; Hiroyuki Tateno; Keiya Fujimori
Bioelectromagnetics, Sep. 2017
The purpose of this study was to evaluate the effects of 3rd-generation (3G) cellular phone radiofrequency-electromagnetic wave (RF-EMW) exposure on fertilization and embryogenesis in mice. Oocytes and spermatozoa were exposed to 3G cellular phone RF-EMWs, 1.95 GHz wideband code division multiple access, at a specific absorption rate of 2 mW/g for 60 min, or to sham exposure. After RF-EMW exposure, in vitro fertilization and intracytoplasmic sperm injection were performed. Rates of fertilization, embryogenesis (8-cell embryo, blastocyst), and chromosome aberration were compared between the combined spermatozoa and oocyte groups: both exposed, both non-exposed, one exposed, and the other non-exposed. Rates of fertilization, embryogenesis, and blastocyst formation did not change significantly across the four groups. Considering that the degree of exposure in the present study was ≥100 times greater than daily exposure of human spermatozoa and even greater than daily exposure of oocytes, the present results indicate safety of RF-EMW exposure in humans. Bioelectromagnetics. 38:466-473, 2017. © 2017 Wiley Periodicals, Inc.

Impairment of triad conditioned facilitation in amyotrophic lateral sclerosis
Stefan J. Groiss; Hitoshi Mochizuki; Ritsuko Hanajima; Carlos Trenado; Setsu Nakatani-Enomoto; Koji Otani; Yoshikazu Ugawa
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION, 2017

免疫療法が有効と考えられたNORSE(new onset refractory status epilepticus)若年女性の1例　　　　　　　　　　　　　　　
Nov. 2016

特異な橋病変を呈した抗NMDA受容体脳炎の1例
Oct. 2016

Effects of 1950MHz W-CDMA-like signal on human spermatozoa
Setsu Nakatani-Enomoto; Miho Okutsu; Satoshi Suzuki; Ryota Suganuma; Stefan Jun Groiss; Suguru Kadowaki; Hiroyuki Enomoto; Keiya Fujimori; Yoshikazu Ugawa
BIOELECTROMAGNETICS, Sep. 2016

Effects of 1950MHz W-CDMA-like signal on human spermatozoa
Setsu Nakatani-Enomoto; Miho Okutsu; Satoshi Suzuki; Ryota Suganuma; Stefan Jun Groiss; Suguru Kadowaki; Hiroyuki Enomoto; Keiya Fujimori; Yoshikazu Ugawa
BIOELECTROMAGNETICS, Sep. 2016

Effects of 1950MHz W-CDMA-like signal on human spermatozoa
Setsu Nakatani-Enomoto; Miho Okutsu; Satoshi Suzuki; Ryota Suganuma; Stefan Jun Groiss; Suguru Kadowaki; Hiroyuki Enomoto; Keiya Fujimori; Yoshikazu Ugawa
BIOELECTROMAGNETICS, Sep. 2016, [Reviewed]

2発刺激―抑制機能の評価(SEP-R)　　　　　　　　　　　　　　　
01 Jul. 2016

【臨床神経生理で何がわかる?[2]脳波・誘発電位・眼球運動】 誘発電位 2発刺激 抑制機能の評価(SEP-R)　　　　　　　　　　　　　　　
榎本 雪; 宇川 義一
Clinical Neuroscience, Jul. 2016

2発刺激―抑制機能の評価(SEP-R)　　　　　　　　　　　　　　　
榎本雪; 宇川義一
Clinical Neuroscience, 01 Jul. 2016

B-4-20 電流知覚閾値の周波数特性に関する一検討(B-4. 環境電磁工学,一般セッション)
野口 義広; 戎 翔平; 上村 佳嗣; 山崎 まどか; 榎本 雪; 宇川 義一
電子情報通信学会総合大会講演論文集, 01 Mar. 2016

Somatosensory-evoked potential modulation by quadripulse transcranial magnetic stimulation in patients with benign myoclonus epilepsy.
Setsu Nakatani-Enomoto; Ritstuko Hanajima; Masashi Hamada; Yasuo Terao; Hideyuki Matsumoto; Yuichiro Shirota; Shinya Ohminami; Shingo Okabe; Masaki Hirose; Koichiro Nakamura; Toshiaki Furubayashi; Stefan Jun Groiss; Shunsuke Kobayashi; Hitoshi Mochizuki; Hiroyuki Enomoto; Yoshikazu Ugawa
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, Feb. 2016
OBJECTIVE: In patients with benign myoclonus epilepsy (ME), giant sensory-evoked potential (SEP) reflects the hyperexcitability of the sensory cortex. The aim of this study was to compare the effect of quadripulse transcranial magnetic stimulation (QPS) on the median nerve SEP between ME patients and healthy subjects. METHODS: Ten healthy volunteers and six ME patients with giant SEP participated in this study. QPSs at interpulse intervals (IPIs) of 5, 30, 50, 100, 500 and 1250 ms were applied over the left primary motor cortex (M1) for 30 min. The peak-to-peak amplitudes of N20 to P25 (N20-P25) and P25 to N33 (P25-N33) components were measured at the left somatosensory cortex. RESULTS: In healthy participants, the P25-N33 was bidirectionally modulated by QPS over M1, following the Bienenstock-Cooper-Munro (BCM) theory. The N20-P25 was not affected by any QPSs. In ME patients, the giant P25-N33 was potentiated after any QPSs. Furthermore, the N20-P25 was also potentiated after QPS at IPIs of 5, 30, 50 100 or 500 ms. CONCLUSIONS: In ME patients, the cascade for long-term depression-like effects may be impaired. SIGNIFICANCE: The giant SEP was furthermore enhanced by QPS.

Influence of phasic muscle contraction upon the quadripulse stimulation (QPS) aftereffects.
Suguru Kadowaki; Hiroyuki Enomoto; Takenobu Murakami; Setsu Nakatani-Enomoto; Shunsuke Kobayashi; Yoshikazu Ugawa
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, Feb. 2016
OBJECTIVE: Contractions of the target muscle influence the aftereffects of repetitive transcranial magnetic stimulation (rTMS). The aim of this paper is to investigate whether or not voluntary hand movement influences the aftereffects of quadripulse stimulation (QPS) on the hand motor area. METHODS: Thirteen healthy volunteers participated in this study. After QPS-5 or QPS-50 intervention over the motor hot spot for the right first dorsal interosseous muscle (FDI), the subjects performed voluntary motor tasks (opening-closing right hand movements at 1 Hz for 1 min). We compared the time courses of MEP size between the conditions with and without voluntary movement. RESULTS: When the subjects moved their hands immediately after QPS, both QPS-5 and QPS-50 aftereffects were abolished. However, if they moved their hands at 20 min after QPS, the long-term aftereffects were preserved. CONCLUSIONS: Voluntary hand movement applied after intervention influences QPS aftereffects, but the magnitude of the influence depends on the delay between QPS and the voluntary movement. SIGNIFICANCE: In the plasticity induction experiments, we should always be mindful of the fact that voluntary movement, including the target muscle, seriously influences the induced long-term effects of QPS.

Somatosensory-evoked potential modulation by quadripulse transcranial magnetic stimulation in patients with benign myoclonus epilepsy.
Setsu Nakatani-Enomoto; Ritstuko Hanajima; Masashi Hamada; Yasuo Terao; Hideyuki Matsumoto; Yuichiro Shirota; Shinya Ohminami; Shingo Okabe; Masaki Hirose; Koichiro Nakamura; Toshiaki Furubayashi; Stefan Jun Groiss; Shunsuke Kobayashi; Hitoshi Mochizuki; Hiroyuki Enomoto; Yoshikazu Ugawa
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, Feb. 2016
OBJECTIVE: In patients with benign myoclonus epilepsy (ME), giant sensory-evoked potential (SEP) reflects the hyperexcitability of the sensory cortex. The aim of this study was to compare the effect of quadripulse transcranial magnetic stimulation (QPS) on the median nerve SEP between ME patients and healthy subjects. METHODS: Ten healthy volunteers and six ME patients with giant SEP participated in this study. QPSs at interpulse intervals (IPIs) of 5, 30, 50, 100, 500 and 1250 ms were applied over the left primary motor cortex (M1) for 30 min. The peak-to-peak amplitudes of N20 to P25 (N20-P25) and P25 to N33 (P25-N33) components were measured at the left somatosensory cortex. RESULTS: In healthy participants, the P25-N33 was bidirectionally modulated by QPS over M1, following the Bienenstock-Cooper-Munro (BCM) theory. The N20-P25 was not affected by any QPSs. In ME patients, the giant P25-N33 was potentiated after any QPSs. Furthermore, the N20-P25 was also potentiated after QPS at IPIs of 5, 30, 50 100 or 500 ms. CONCLUSIONS: In ME patients, the cascade for long-term depression-like effects may be impaired. SIGNIFICANCE: The giant SEP was furthermore enhanced by QPS.

Somatosensory-evoked potential modulation by quadripulse transcranial magnetic stimulation in patients with benign myoclonus epilepsy.
Setsu Nakatani-Enomoto; Ritstuko Hanajima; Masashi Hamada; Yasuo Terao; Hideyuki Matsumoto; Yuichiro Shirota; Shinya Ohminami; Shingo Okabe; Masaki Hirose; Koichiro Nakamura; Toshiaki Furubayashi; Stefan Jun Groiss; Shunsuke Kobayashi; Hitoshi Mochizuki; Hiroyuki Enomoto; Yoshikazu Ugawa
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, Feb. 2016, [Reviewed]
OBJECTIVE: In patients with benign myoclonus epilepsy (ME), giant sensory-evoked potential (SEP) reflects the hyperexcitability of the sensory cortex. The aim of this study was to compare the effect of quadripulse transcranial magnetic stimulation (QPS) on the median nerve SEP between ME patients and healthy subjects. METHODS: Ten healthy volunteers and six ME patients with giant SEP participated in this study. QPSs at interpulse intervals (IPIs) of 5, 30, 50, 100, 500 and 1250 ms were applied over the left primary motor cortex (M1) for 30 min. The peak-to-peak amplitudes of N20 to P25 (N20-P25) and P25 to N33 (P25-N33) components were measured at the left somatosensory cortex. RESULTS: In healthy participants, the P25-N33 was bidirectionally modulated by QPS over M1, following the Bienenstock-Cooper-Munro (BCM) theory. The N20-P25 was not affected by any QPSs. In ME patients, the giant P25-N33 was potentiated after any QPSs. Furthermore, the N20-P25 was also potentiated after QPS at IPIs of 5, 30, 50 100 or 500 ms. CONCLUSIONS: In ME patients, the cascade for long-term depression-like effects may be impaired. SIGNIFICANCE: The giant SEP was furthermore enhanced by QPS.

Influence of phasic muscle contraction upon the quadripulse stimulation (QPS) aftereffects.
Suguru Kadowaki; Hiroyuki Enomoto; Takenobu Murakami; Setsu Nakatani-Enomoto; Shunsuke Kobayashi; Yoshikazu Ugawa
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, Feb. 2016
OBJECTIVE: Contractions of the target muscle influence the aftereffects of repetitive transcranial magnetic stimulation (rTMS). The aim of this paper is to investigate whether or not voluntary hand movement influences the aftereffects of quadripulse stimulation (QPS) on the hand motor area. METHODS: Thirteen healthy volunteers participated in this study. After QPS-5 or QPS-50 intervention over the motor hot spot for the right first dorsal interosseous muscle (FDI), the subjects performed voluntary motor tasks (opening-closing right hand movements at 1 Hz for 1 min). We compared the time courses of MEP size between the conditions with and without voluntary movement. RESULTS: When the subjects moved their hands immediately after QPS, both QPS-5 and QPS-50 aftereffects were abolished. However, if they moved their hands at 20 min after QPS, the long-term aftereffects were preserved. CONCLUSIONS: Voluntary hand movement applied after intervention influences QPS aftereffects, but the magnitude of the influence depends on the delay between QPS and the voluntary movement. SIGNIFICANCE: In the plasticity induction experiments, we should always be mindful of the fact that voluntary movement, including the target muscle, seriously influences the induced long-term effects of QPS.

2発刺激―抑制機能の評価(SEP-R)　　　　　　　　　　　　　　　
榎本雪; 宇川義一
Clinical Neuroscience, 2016

Influence of phasic muscle contraction upon the quadripulse stimulation (QPS) aftereffects.　　　　　　　　　　　　　　　
Kadowaki S; Enomoto H; Murakami T; Nakatani-Enomoto S; Kobayashi S; Ugawa Y
Clin Neurophysiol, 2016

Effects of 1950 MHz W-CDMA-like signal on human spermatozoa　　　　　　　　　　　　　　　
Setsu Nakatani-Enomoto; Miho Okutsu; Satoshi Suzuki; Ryota Suganuma; Stefan Jun Groiss; Suguru Kadowaki; Hiroyuki Enomoto; Keiya Fujimori; Yoshikazu Ugawa
Bioelectromagnetics, 2016

Influence of phasic muscle contraction upon the quadripulse stimulation (QPS) aftereffects.　　　　　　　　　　　　　　　
Kadowaki S; Enomoto H; Murakami T; Nakatani-Enomoto S; Kobayashi S; Ugawa Y
Clin Neurophysiol, 2016

Effects of 1950 MHz W-CDMA-like signal on human spermatozoa　　　　　　　　　　　　　　　
Setsu Nakatani-Enomoto; Miho Okutsu; Satoshi Suzuki; Ryota Suganuma; Stefan Jun Groiss; Suguru Kadowaki; Hiroyuki Enomoto; Keiya Fujimori; Yoshikazu Ugawa
Bioelectromagnetics, 2016, [Reviewed]

Influence of phasic muscle contraction upon the quadripulse stimulation (QPS) aftereffects.　　　　　　　　　　　　　　　
Kadowaki S; Enomoto H; Murakami T; Nakatani-Enomoto S; Kobayashi S; Ugawa Y
Clin Neurophysiol, 2016

Effects of L-Dopa and pramipexole on plasticity induced by QPS in human motor cortex.
Hiroyuki Enomoto; Yasuo Terao; Suguru Kadowaki; Koichiro Nakamura; Arata Moriya; Setsu Nakatani-Enomoto; Shunsuke Kobayashi; Akioh Yoshihara; Ritsuko Hanajima; Yoshikazu Ugawa
Journal of neural transmission (Vienna, Austria : 1996), Sep. 2015
Abnormal plasticity has been reported in the brain of patients with Parkinson's disease (PD), especially in the striatum. Although both L-Dopa and dopamine agonist remain to be the mainstay of the treatment in PD, their differential effects on cortical plasticity are unclear. We applied quadripulse stimulation (QPS) over the primary motor cortex (M1) in ten normal subjects to induce bidirectional long-term motor cortical plasticity. A long-term potentiation (LTP)-like effect was induced in the primary motor cortex (M1) by high-frequency QPS5 (interpulse interval of 5 ms) over M1, whereas a long-term depression (LTD)-like effect was induced by low-frequency QPS50 (interpulse interval of 50 ms), and the effects lasted up to 90 min after the stimulation pulses have ceased. In a double-blind randomized placebo-controlled crossover design, L-Dopa carbidopa 100 mg, pramipexole 1.5 mg [150 mg LED (L-Dopa equivalent dose)], or placebo was administered to the subjects 30 min before applying QPS. L-Dopa enhanced both LTP- and LTD-like plasticity as compared to placebo. In contrast, neither an LTP-like effect nor an LTD-like effect was modulated by pramipexole. The lack of LTP enhancement by pramipexole is compatible with the finding that D1 activation strengthens LTP because pramipexole is almost purely a D2 agonist. The lack of LTD enhancement by pramipexole is also consistent with the finding that both D1 and D2 coactivation is required for LTD. This is the first report to show that dopamine enhances LTD as well as LTP in the human brain and that coactivation of D1 and D2 is a requisite for LTD enhancement in normal humans.

Effects of L-Dopa and pramipexole on plasticity induced by QPS in human motor cortex.
Hiroyuki Enomoto; Yasuo Terao; Suguru Kadowaki; Koichiro Nakamura; Arata Moriya; Setsu Nakatani-Enomoto; Shunsuke Kobayashi; Akioh Yoshihara; Ritsuko Hanajima; Yoshikazu Ugawa
Journal of neural transmission (Vienna, Austria : 1996), Sep. 2015
Abnormal plasticity has been reported in the brain of patients with Parkinson's disease (PD), especially in the striatum. Although both L-Dopa and dopamine agonist remain to be the mainstay of the treatment in PD, their differential effects on cortical plasticity are unclear. We applied quadripulse stimulation (QPS) over the primary motor cortex (M1) in ten normal subjects to induce bidirectional long-term motor cortical plasticity. A long-term potentiation (LTP)-like effect was induced in the primary motor cortex (M1) by high-frequency QPS5 (interpulse interval of 5 ms) over M1, whereas a long-term depression (LTD)-like effect was induced by low-frequency QPS50 (interpulse interval of 50 ms), and the effects lasted up to 90 min after the stimulation pulses have ceased. In a double-blind randomized placebo-controlled crossover design, L-Dopa carbidopa 100 mg, pramipexole 1.5 mg [150 mg LED (L-Dopa equivalent dose)], or placebo was administered to the subjects 30 min before applying QPS. L-Dopa enhanced both LTP- and LTD-like plasticity as compared to placebo. In contrast, neither an LTP-like effect nor an LTD-like effect was modulated by pramipexole. The lack of LTP enhancement by pramipexole is compatible with the finding that D1 activation strengthens LTP because pramipexole is almost purely a D2 agonist. The lack of LTD enhancement by pramipexole is also consistent with the finding that both D1 and D2 coactivation is required for LTD. This is the first report to show that dopamine enhances LTD as well as LTP in the human brain and that coactivation of D1 and D2 is a requisite for LTD enhancement in normal humans.

Effects of L-Dopa and pramipexole on plasticity induced by QPS in human motor cortex.
Hiroyuki Enomoto; Yasuo Terao; Suguru Kadowaki; Koichiro Nakamura; Arata Moriya; Setsu Nakatani-Enomoto; Shunsuke Kobayashi; Akioh Yoshihara; Ritsuko Hanajima; Yoshikazu Ugawa
Journal of neural transmission (Vienna, Austria : 1996), Sep. 2015
Abnormal plasticity has been reported in the brain of patients with Parkinson's disease (PD), especially in the striatum. Although both L-Dopa and dopamine agonist remain to be the mainstay of the treatment in PD, their differential effects on cortical plasticity are unclear. We applied quadripulse stimulation (QPS) over the primary motor cortex (M1) in ten normal subjects to induce bidirectional long-term motor cortical plasticity. A long-term potentiation (LTP)-like effect was induced in the primary motor cortex (M1) by high-frequency QPS5 (interpulse interval of 5 ms) over M1, whereas a long-term depression (LTD)-like effect was induced by low-frequency QPS50 (interpulse interval of 50 ms), and the effects lasted up to 90 min after the stimulation pulses have ceased. In a double-blind randomized placebo-controlled crossover design, L-Dopa carbidopa 100 mg, pramipexole 1.5 mg [150 mg LED (L-Dopa equivalent dose)], or placebo was administered to the subjects 30 min before applying QPS. L-Dopa enhanced both LTP- and LTD-like plasticity as compared to placebo. In contrast, neither an LTP-like effect nor an LTD-like effect was modulated by pramipexole. The lack of LTP enhancement by pramipexole is compatible with the finding that D1 activation strengthens LTP because pramipexole is almost purely a D2 agonist. The lack of LTD enhancement by pramipexole is also consistent with the finding that both D1 and D2 coactivation is required for LTD. This is the first report to show that dopamine enhances LTD as well as LTP in the human brain and that coactivation of D1 and D2 is a requisite for LTD enhancement in normal humans.

ニューロサイエンスの最新情報 Quadripulse transcranial magnetic stimulation(QPS) ヒトでの新しい可塑性誘導法　　　　　　　　　　　　　　　
榎本 雪; 宇川 義一
Clinical Neuroscience, Jun. 2015

B-4-28 LabVIEWを用いた電流感知閾値実験システム(B-4.環境電磁工学)
山下 翠; 上村 佳嗣; 山崎 まどか; 榎本 雪; 和氣 加奈子; 宇川 義一
電子情報通信学会総合大会講演論文集, 24 Feb. 2015

Quadripulse transcranial magnetic stimulation（QPS）―ヒトでの新しい可塑性誘導法　　　　　　　　　　　　　　　
榎本雪; 宇川義一
Clinical Neuroscience, 2015

Quadripulse transcranial magnetic stimulation（QPS）―ヒトでの新しい可塑性誘導法　　　　　　　　　　　　　　　
2015

Quadripulse transcranial magnetic stimulation（QPS）―ヒトでの新しい可塑性誘導法　　　　　　　　　　　　　　　
榎本雪; 宇川義一
Clinical Neuroscience, 2015

Effects of L-Dopa and pramipexole on plasticity induced by QPS in human motor cortex.　　　　　　　　　　　　　　　
Enomoto H; Terao Y; Kadowaki S; Nakamura K; Moriya A; Nakatani-Enomoto S; Kobayashi S; Yoshihara A; Hanajima R; Ugawa Y
J Neural Transm, 2015, [Reviewed]

当院における脳脊髄液漏出症の検討 脊髄MRI横断像での髄液漏出所見について　　　　　　　　　　　　　　　
Dec. 2014

ステロイド治療が有効であった脳アミロイドアンギオパチー関連白質脳症の一例　　　　　　　　　　　　　　　
Dec. 2014

脳アミロイド血管症を伴う白質脳症 神経脱落症状および皮質灰白質を一部含む皮質下白質病変に対するステロイド治療の奏効(Cerebral amyloid angiopathy-related leukoencephalopathy: Successful steroid treatment for neurological deficits and subcortical white matter lesions partly involving the cortical gray matter)　　　　　　　　　　　　　　　
Murakami Takenobu; Morimoto Julia; Hoshi Akihiko; Nakatani-Enomoto Setsu; Ichikawa Masahiro; Tasaki Kazuhiro; Ogura Ryosuke; Toyoshima Yasuko; Kakita Akiyoshi; Saito Kiyoshi; Takahashi Hitoshi; Ugawa Yoshikazu
Neurology and Clinical Neuroscience, Jul. 2014

Complex fasciculation potentials and survival in amyotrophic lateral sclerosis
Toshio Shimizu; Yumi Fujimaki; Setsu Nakatani-Enomoto; Shiro Matsubara; Kazuhiko Watabe; Paolo Maria Rossini; Yoshikazu Ugawa
CLINICAL NEUROPHYSIOLOGY, May 2014

Complex fasciculation potentials and survival in amyotrophic lateral sclerosis
Toshio Shimizu; Yumi Fujimaki; Setsu Nakatani-Enomoto; Shiro Matsubara; Kazuhiko Watabe; Paolo Maria Rossini; Yoshikazu Ugawa
CLINICAL NEUROPHYSIOLOGY, May 2014, [Reviewed]

B-4-43 ヒトの電流感知閾値実験システムの改良(B-4.環境電磁工学,一般セッション)
山下 翠; 上村 佳嗣; 宇川 義一; 山崎 まどか; 榎本 雪
電子情報通信学会総合大会講演論文集, 04 Mar. 2014

Complex fasciculation potentials and survival in amyotrophic lateral sclerosis　　　　　　　　　　　　　　　
Shimizu T; Fujimaki Y; Nakatani-Enomoto S; Matsubara S; Watabe K; Rossini PM; Ugawa Y
Clin Neurophysiol, 2014

Cerebral amyloid angiopathy-related leukoencepha lopathy:Successful steroid treatment for neurological deficits andsubcortical white matter lesions partly involving the corticalgray matter　　　　　　　　　　　　　　　
Murakami T; Morimoto J; Hoshi A; Nakatani-Enomoto S; Ichikawa M; Tasaki K; Ogura R; Toyoshima Y; Kakita A; Saito K; Takahashi H; Ugawa Y
Neurology and Clinical Neuroscience, 2014, [Reviewed]

Complex fasciculation potentials and survival in amyotrophic lateral sclerosis　　　　　　　　　　　　　　　
Shimizu T; Fujimaki Y; Nakatani-Enomoto S; Matsubara S; Watabe K; Rossini PM; Ugawa Y
Clin Neurophysiol, 2014

Complex fasciculation potentials and survival in amyotrophic lateral sclerosis　　　　　　　　　　　　　　　
Shimizu T; Fujimaki Y; Nakatani-Enomoto S; Matsubara S; Watabe K; Rossini PM; Ugawa Y
Clin Neurophysiol, 2014, [Reviewed]

Cerebral amyloid angiopathy-related leukoencepha lopathy:Successful steroid treatment for neurological deficits andsubcortical white matter lesions partly involving the corticalgray matter　　　　　　　　　　　　　　　
Murakami T; Morimoto J; Hoshi A; Nakatani-Enomoto S; Ichikawa M; Tasaki K; Ogura R; Toyoshima Y; Kakita A; Saito K; Takahashi H; Ugawa Y
Neurology and Clinical Neuroscience, 2014

Effects of Electromagnetic Fields Emitted From W-CDMA-like Mobile Phones on Sleep in Humans
Nakatani-Enomoto, Setsu; Furubayashi, Toshiaki; Ushiyama, Akira; Groiss, Stefan Jun; Ueshima, Kazumune; Sokejima, Shigeru; Simba, Ally Y.; Wake, Kanako; Watanabe, So-ichi; Nishikawa, Masami; Miyawaki, Kaori; Taki, Masao; Ugawa, Yoshikazu
BIOELECTROMAGNETICS, Dec. 2013

Effects of Electromagnetic Fields Emitted From W-CDMA-like Mobile Phones on Sleep in Humans
Nakatani-Enomoto, Setsu; Furubayashi, Toshiaki; Ushiyama, Akira; Groiss, Stefan Jun; Ueshima, Kazumune; Sokejima, Shigeru; Simba, Ally Y.; Wake, Kanako; Watanabe, So-ichi; Nishikawa, Masami; Miyawaki, Kaori; Taki, Masao; Ugawa, Yoshikazu
BIOELECTROMAGNETICS, Dec. 2013, [Reviewed]

Effects of Electromagnetic Fields Emitted From W-CDMA-like Mobile Phones on Sleep in Humans
Nakatani-Enomoto, Setsu; Furubayashi, Toshiaki; Ushiyama, Akira; Groiss, Stefan Jun; Ueshima, Kazumune; Sokejima, Shigeru; Simba, Ally Y.; Wake, Kanako; Watanabe, So-ichi; Nishikawa, Masami; Miyawaki, Kaori; Taki, Masao; Ugawa, Yoshikazu
BIOELECTROMAGNETICS, Dec. 2013

非定型的なgiant SEPを認めた大脳皮質基底核症候群の1例　　　　　　　　　　　　　　　
Sep. 2013

眼で見る神経内科 Gliomatosis cerebriの誘発電位検査　　　　　　　　　　　　　　　
吉原 章王; 榎本 雪; 高橋 均; 宇川 義一
神経内科, Jun. 2013

Cortical hemoglobin concentration changes underneath the coil after single-pulse transcranial magnetic stimulation: a near-infrared spectroscopy study
Toshiaki Furubayashi; Hitoshi Mochizuki; Yasuo Terao; Noritoshi Arai; Ritsuko Hanajima; Masashi Hamada; Hideyuki Matsumoto; Setsu Nakatani-Enomoto; Shingo Okabe; Akihiro Yugeta; Satomi Inomata-Terada; Yoshikazu Ugawa
JOURNAL OF NEUROPHYSIOLOGY, Mar. 2013

Cortical hemoglobin concentration changes underneath the coil after single-pulse transcranial magnetic stimulation: a near-infrared spectroscopy study
Toshiaki Furubayashi; Hitoshi Mochizuki; Yasuo Terao; Noritoshi Arai; Ritsuko Hanajima; Masashi Hamada; Hideyuki Matsumoto; Setsu Nakatani-Enomoto; Shingo Okabe; Akihiro Yugeta; Satomi Inomata-Terada; Yoshikazu Ugawa
JOURNAL OF NEUROPHYSIOLOGY, Mar. 2013

Gliomatosis cerebriの誘発電位検査　　　　　　　　　　　　　　　
吉原章王; 榎本雪; 高橋均; 宇川義一
神経内科, 2013

Quadri-pulse stimulation induces stimulation frequency dependent cortical hemoglobin concentration changes within the ipsilateral motor cortical network.
Stefan Jun Groiss; Hitoshi Mochizuki; Toshiaki Furubayashi; Shunsuke Kobayashi; Setsu Nakatani-Enomoto; Koichiro Nakamura; Yoshikazu Ugawa
Brain stimulation, Jan. 2013
BACKGROUND: Imaging studies investigating repetitive transcranial magnetic stimulation (rTMS) mediated hemodynamic consequences revealed inconsistent results, mainly due to differences in rTMS parameters and technical difficulties with simultaneous recordings during rTMS. OBJECTIVE/HYPOTHESIS: Quadri-pulse rTMS (QPS) induces bidirectional long-term plasticity of the human primary motor cortex (M1). To evaluate its on-line effects, near infrared spectroscopy (NIRS) recordings were performed during QPS. We hypothesized that on-line effects during QPS are different from long-term aftereffects. METHODS: Using a novel TMS - on-line multi-channel NIRS setup we recorded hemoglobin concentration [Hb] changes at the stimulated M1 and adjacent sensory-motor areas during QPS protocols inducing oppositely directed aftereffects (QPS-5: interstimulus interval (ISI) 5 ms, potentiation; QPS-50: ISI 50 ms, depression). In two experiments we studied NIRS changes during either single or repeated QPS bursts. RESULTS: The repetitive QPS-5 bursts significantly decreased oxyhemoglobin concentration ([oxy-Hb]) in the ipsilateral M1. A single QPS-5 burst decreased [oxy-Hb] in the M1 and premotor cortex. QPS-50 induced no significant NIRS changes at any sites. CONCLUSIONS: QPS can significantly alter cortical hemodynamics depending on the stimulation frequency. While bidirectional long-term aftereffects of QPS reflect synaptic efficacy changes, unidirectional on-line effects during QPS may represent pure electrophysiological property changes within the cell membrane or synapse. Since neuronal postexcitatory inhibitory postsynaptic potentials typically peak within the first 10-20 ms, only pulses delivered at higher frequencies may lead to summation of the inhibitory effects, resulting in [oxy-Hb] decrease only after QPS-5. Our new TMS-NIRS setup may be valuable to investigate TMS induced neurovascular coupling mechanisms in humans.

Gliomatosis cerebriの誘発電位検査　　　　　　　　　　　　　　　
2013, [Reviewed]

Quadri-pulse stimulation induces stimulation frequency dependent cortical hemoglobin concentration changes within the ipsilateral motor cortical network.
Stefan Jun Groiss; Hitoshi Mochizuki; Toshiaki Furubayashi; Shunsuke Kobayashi; Setsu Nakatani-Enomoto; Koichiro Nakamura; Yoshikazu Ugawa
Brain stimulation, Jan. 2013
BACKGROUND: Imaging studies investigating repetitive transcranial magnetic stimulation (rTMS) mediated hemodynamic consequences revealed inconsistent results, mainly due to differences in rTMS parameters and technical difficulties with simultaneous recordings during rTMS. OBJECTIVE/HYPOTHESIS: Quadri-pulse rTMS (QPS) induces bidirectional long-term plasticity of the human primary motor cortex (M1). To evaluate its on-line effects, near infrared spectroscopy (NIRS) recordings were performed during QPS. We hypothesized that on-line effects during QPS are different from long-term aftereffects. METHODS: Using a novel TMS - on-line multi-channel NIRS setup we recorded hemoglobin concentration [Hb] changes at the stimulated M1 and adjacent sensory-motor areas during QPS protocols inducing oppositely directed aftereffects (QPS-5: interstimulus interval (ISI) 5 ms, potentiation; QPS-50: ISI 50 ms, depression). In two experiments we studied NIRS changes during either single or repeated QPS bursts. RESULTS: The repetitive QPS-5 bursts significantly decreased oxyhemoglobin concentration ([oxy-Hb]) in the ipsilateral M1. A single QPS-5 burst decreased [oxy-Hb] in the M1 and premotor cortex. QPS-50 induced no significant NIRS changes at any sites. CONCLUSIONS: QPS can significantly alter cortical hemodynamics depending on the stimulation frequency. While bidirectional long-term aftereffects of QPS reflect synaptic efficacy changes, unidirectional on-line effects during QPS may represent pure electrophysiological property changes within the cell membrane or synapse. Since neuronal postexcitatory inhibitory postsynaptic potentials typically peak within the first 10-20 ms, only pulses delivered at higher frequencies may lead to summation of the inhibitory effects, resulting in [oxy-Hb] decrease only after QPS-5. Our new TMS-NIRS setup may be valuable to investigate TMS induced neurovascular coupling mechanisms in humans.

Gliomatosis cerebriの誘発電位検査　　　　　　　　　　　　　　　
吉原章王; 榎本雪; 高橋均; 宇川義一
神経内科, 2013, [Reviewed]

Bidirectional modulation of sensory cortical excitability by quadripulse transcranial magnetic stimulation (QPS) in humans
Setsu Nakatani-Enomoto; Ritstuko Hanajima; Masashi Hamada; Yasuo Terao; Hideyuki Matsumoto; Yuichiro Shirota; Shingo Okabe; Masaki Hirose; Koichiro Nakamura; Toshiaki Furubayashi; Shunsuke Kobayashi; Hitoshi Mochizuki; Hiroyuki Enomoto; Yoshikazu Ugawa
CLINICAL NEUROPHYSIOLOGY, Jul. 2012, [Reviewed]

Ataxic Hemiparesis: Neurophysiological Analysis by Cerebellar Transcranial Magnetic Stimulation
Saeko Kikuchi; Hitoshi Mochizuki; Arata Moriya; Setsu Nakatani-Enomoto; Koichiro Nakamura; Ritsuko Hanajima; Yoshikazu Ugawa
CEREBELLUM, Mar. 2012, [Reviewed]

Some evidence supporting the safety of quadripulse stimulation (QPS)
Setsu Nakatani-Enomoto; Ritsuko Hanajima; Masashi Hamada; Hitoshi Mochizuki; Shunsuke Kobayashi; Hiroyuki Enomoto; Yoshihiro Sugiura; Hideyuki Matsumoto; Toshiaki Furubayashi; Yasuo Terao; Fumio Sato; Yoshikazu Ugawa
BRAIN STIMULATION, Oct. 2011, [Reviewed]

Short-interval intracortical inhibition in Parkinson's disease using anterior-posterior directed currents
R. Hanajima; Y. Terao; Y. Shirota; S. Ohminami; S. Nakatani-Enomoto; S. Okabe; H. Matsumoto; R. Tsutsumi; Y. Ugawa
EXPERIMENTAL BRAIN RESEARCH, Oct. 2011

On-line effects of quadripulse transcranial magnetic stimulation (QPS) on the contralateral hemisphere studied with somatosensory evoked potentials and near infrared spectroscopy
Masaki Hirose; Hitoshi - Mochizuki; Stefan Jun Groiss; Yumiko Tanji; Koichiro Nakamura; Setsu Nakatani-Enomoto; Hiroyuki Enomoto; Masatoyo Nishizawa; Yoshikazu Ugawa
EXPERIMENTAL BRAIN RESEARCH, Oct. 2011

Two cases of posterior spinal artery syndrome (PSAS)
Sep. 2011

Two cases of posterior spinal artery syndrome (PSAS)
Arata Moriya; Suguru Kadowaki; Saeko Kikuchi; Setsu Nakatani-Enomoto; Hitoshi Mochizuki; Yoshikazu Ugawa
Clinical Neurology, Sep. 2011, [Reviewed]

Triad Stimulation Frequency for Cortical Facilitation in Cortical Myoclonus
R. Hanajima; Y. Terao; S. Nakatani-Enomoto; S. Okabe; Y. Shirota; S. Oominami; H. Matsumoto; S. Tsuji; Y. Ugawa
MOVEMENT DISORDERS, Mar. 2011

当科における筋萎縮性側索硬化症の初期診断確定までの経過について　　　　　　　　　　　　　　　
Dec. 2010

Cortico-conus motor conduction time (CCCT) for leg muscles
Hideyuki Matsumoto; Ritsuko Hanajima; Yuichiro Shirota; Masashi Hamada; Yasuo Terao; Shinya Ohminami; Toshiaki Furubayashi; Setsu Nakatani-Enomoto; Yoshikazu Ugawa
CLINICAL NEUROPHYSIOLOGY, Nov. 2010, [Reviewed]

Influence of Short-Interval Intracortical Inhibition on Short-Interval Intracortical Facilitation in Human Primary Motor Cortex
Yuichiro Shirota; Masashi Hamada; Yasuo Terao; Hideyuki Matsumoto; Shinya Ohminami; Toshiaki Furubayashi; Setsu Nakatani-Enomoto; Yoshikazu Ugawa; Ritsuko Hanajima
JOURNAL OF NEUROPHYSIOLOGY, Sep. 2010, [Reviewed]

Wernicke encephalopathy in a non-alcoholic patient with diabetic nephropathy under hemodialysis
Jun. 2010

Prominent cauda equina involvement in patients with chronic inflammatory demyelinating polyradiculoneuropathy
Hideyuki Matsumoto; Ritsuko Hanajima; Yasuo Terao; Akihiro Yugeta; Masashi Hamada; Yuichiro Shirota; Shinya Ohminami; Setsu Nakatani-Enomoto; Shoji Tsuji; Yoshikazu Ugawa
JOURNAL OF THE NEUROLOGICAL SCIENCES, Mar. 2010, [Reviewed]

糖尿病性腎症に対する血液透析療法中に非アルコール性ウェルニッケ脳症を呈した1例　　　　　　　　　　　　　　　
2010, [Reviewed]

内科疾患に伴う神経障害 Wernicke脳症　　　　　　　　　　　　　　　
2010

Motor cortical epilepsia partialis continua in a patient with a localized sensory cortical lesion
Setsu Nakatani-Enomoto; Yasuo Terao; Ritsuko Hanajima; Shunichi Matsuda; Shinya Ohminami; Satomi Inomata-Terada; Hideyuki Matsumoto; Akihiro Yugeta; Tomotaka Yamamoto; Jun Goto; Masato Yumoto; Shoji Tsuji; Yoshikazu Ugawa
CLINICAL NEUROLOGY AND NEUROSURGERY, Nov. 2009, [Reviewed]

Postural Tremor in X-Linked Spinal and Bulbar Muscular Atrophy
Ritsuko Hanajima; Yasuo Terao; Setsu Nakatani-Enomoto; Masashi Hamada; Akihiro Yugeta; Hideyuki Matsumoto; Tomotaka Yamamoto; Shoji Tsuji; Yoshikazu Ugawa
MOVEMENT DISORDERS, Oct. 2009, [Reviewed]

Primary motor cortical metaplasticity induced by priming over the supplementary motor area
Masashi Hamada; Ritsuko Hanajima; Yasuo Terao; Shingo Okabe; Setsu Nakatani-Enomoto; Toshiaki Furubayashi; Hideyuki Matsumoto; Yuichiro Shirota; Shinya Ohminami; Yoshikazu Ugawa
JOURNAL OF PHYSIOLOGY-LONDON, Oct. 2009, [Reviewed]

Forty-hertz triple-pulse stimulation induces motor cortical facilitation in humans
Ritsuko Hanajima; Yasuo Terao; Masashi Hamada; Shingo Okabe; Setsu Nakatani-Enomoto; Toshiaki Furubayashi; Akihiro Yugeta; Satomi Inomata-Terada; Yoshikazu Ugawa
BRAIN RESEARCH, Oct. 2009, [Reviewed]

Magnetic stimulation of the cauda equina in the spinal canal with a flat, large round coil.
Matsumoto H; Octaviana F; Terao Y; Hanajima R; Yugeta A; Hamada M; Inomata-Terada S; Nakatani-Enomoto S; Tsuji S; Ugawa Y
Journal of the neurological sciences, Sep. 2009, [Reviewed]

Magnetic lumbosacral motor root stimulation with a flat, large round coil
Hideyuki Matsumoto; Fitri Octaviana; Ritsuko Hanajima; Yasuo Terao; Akihiro Yugeta; Masashi Hamada; Satomi Inomata-Terada; Setsu Nakatani-Enomoto; Shoji Tsuji; Yoshikazu Ugawa
CLINICAL NEUROPHYSIOLOGY, Apr. 2009, [Reviewed]

Double-Pulse Magnetic Brain Stem Stimulation: Mimicking Successive Descending Volleys
Hideyuki Matsumoto; Ritsuko Hanajima; Masashi Hamada; Yasuo Terao; Akihiro Yugeta; Satomi Inomata-Terada; Setsu Nakatani-Enomoto; Shoji Tsuji; Yoshikazu Ugawa
JOURNAL OF NEUROPHYSIOLOGY, Dec. 2008, [Reviewed]

Bidirectional long-term motor cortical plasticity and metaplasticity induced by quadripulse transcranial magnetic stimulation
Masashi Hamada; Yasuo Terao; Ritsuko Hanajima; Yuichiro Shirota; Setsu Nakatani-Enomoto; Toshiaki Furubayashi; Hideyuki Matsumoto; Yoshikazu Ugawa
JOURNAL OF PHYSIOLOGY-LONDON, Aug. 2008, [Reviewed]

Paired stimulation study of the median nerve sensory action potential in diabetic patients
S. Nakatani-Enomoto; M. Bandoh; Y. Kita; H. Yamanouchi; H. Enomoto; T. Kimura; K. Hashimoto; O. Yahara; Y. Ugawa
ACTA NEUROLOGICA SCANDINAVICA, Aug. 2008, [Reviewed]

A case of sensorineural hearing loss and headaches with MPO-ANCA
ABURAKAWA Y
2008, [Reviewed]

Comparison of different methods for estimating motor threshold with transcranial magnetic stimulation
Ritsuko Hanajima; Renbin Wang; Setsu Nakatani-Enornoto; Masashi Hamada; Yasuo Terao; Toshiaki Furubayashi; Shingo Okabe; Satomi Inomata-Terada; Akihiro Yugeta; John C. Rothwell; Yoshikazu Ugawa
CLINICAL NEUROPHYSIOLOGY, Sep. 2007, [Reviewed]

An Adult Case of Relapsing Human Herpesvirus-6 Encephalitis
Jun Sawada; Setsu Nakatani-Enomoto; Hitoshi Aizawa; Takayuki Katayama; Takashi Ito; Yoko Aburakawa; Kenjiro Kikuchi
INTERNAL MEDICINE, 2007, [Reviewed]

Edaravone diminishes free radicals from circulating neutrophils in patients with ischemic brain attack
Hitoshi Aizawa; Yoshihiro Makita; Kazuhiro Sumitomo; Yoko Aburakawa; Takayuki Katayama; Setsu Nakatani-Enomoto; Yasuhiro Suzuki; Kazuhiko Fujiwara; Hiroyuki Enomoto; Kenji Kuroda; Takashi Kimura; Osamu Yahara; Satoshi Koyama; Junichi Maruyama; Masao Nakamura; Naoyuki Hasebe; Kenjiro Kikuchi
INTERNAL MEDICINE, 2006, [Reviewed]

Multiple and recurrent systemic thrombotic events associated with congenital anomaly of inferior vena cava
N Takehara; N Hasebe; S Enomoto; T Takeuchi; F Takahashi; T Ota; Y Kawamura; K Kikuchi
JOURNAL OF THROMBOSIS AND THROMBOLYSIS, Apr. 2005, [Reviewed]

パーキンソン病講座 リハビリテーション戦略
2005

Transient swelling of peripheral nerves in a case of neurosarcoidosis
S Nakatani-Enomoto; H Aizawa; S Koyama; K Kuroda; T Kimura; K Kikuchi
INTERNAL MEDICINE, Nov. 2004, [Reviewed]

筋強直性ジストロフィー患者の便秘とイレウス　　　　　　　　　　　　　　　
2004

医原性プリオン病—特に硬膜移植による Creutzfeldt-Jakob 病　　　　　　　　　　　　　　　
2003

An autopsy case of amyotrophic lateral sclerosis accompanied by syndrome of inappropriate secretion of antidiuretic hormone
S Koyama; H Aizawa; T Haga; S Nakatani-Enomoto; K Kikuchi
INTERNAL MEDICINE, May 2002, [Reviewed]

感染性プリオン病. 硬膜移植後のプリオン病と変異型CJD　　　　　　　　　　　　　　　
2002

ヒト免疫グロブリン静注療法が有効であった亜急性外眼筋炎の1例　　　　　　　　　　　　　　　
2002, [Reviewed]

肺小細胞癌を有し抗GM1抗体が陽性だった，感覚運動ニューロパチーの1例　　　　　　　　　　　　　　　
2002, [Reviewed]

硬膜移植とCJD　　　　　　　　　　　　　　　
2002

Stiff-person syndrome associated with invasive thymoma: a case report
H Hagiwara; S Enomoto-Nakatani; K Sakai; Y Ugawa; S Kusunoki; Kanazawa, I
JOURNAL OF THE NEUROLOGICAL SCIENCES, Dec. 2001, [Reviewed]

ガス産生性嫌気性細菌による脊髄硬膜外膿瘍の1例　　　　　　　　　　　　　　　
1998, [Reviewed]

Anti-ganglioside Antibodies and Plasmapheresis in Patients with Motor Neuropathy and Amyotrophic Lateral Sclerosis.
YOSHINO Hiide; MASUDA Masayuki; NAKATANI Setsu; SATO Takeshi
Japanese Journal of National Medical Services, 1996, [Reviewed]
Anti-ganglioside antibodies were examined in patients with ALS and motor neuropathy. Plasmapheresis were applied especially to such patients with high-titered anti-GM1 antibodies. Antibodies have been detected in 17 out of 33 ALS patients. In addition to GM1, anti-SGPG (sulfated glucuronyl paragloboside), anti-GA1 (asialo-GM1), or anti-GM3 antibodies were demonstrated in some ALS patients. Plasmapheresis as well as immunosuppressant agents were effective in the patient with motor neuropathy. In ALS, plasmapheresis was not effective, however, human immunoglobulin infusion therapy showed transient improvement. These results indicate that autoimmune mechanism might be involved in some ALS patients who have high-titered anti-ganglioside antibody.

ペランパネルが脳の可塑性に与える影響
Oct. 2019

慢性炎症性脱髄性多発根神経炎における馬尾伝導障害と髄液蛋白上昇との関連
松本英之; 濱田雅; 代田悠一郎; 弓削田晃弘; 榎本雪; 花島律子; 寺尾安生; 宇川義一; 宇川義一
日本神経学会学術大会プログラム・抄録集, 2019

排尿障害を呈した神経核内封入体病の1例　　　　　　　　　　　　　　　
Aug. 2016

磁気刺激の臨床応用と治療効果 磁気刺激法による神経可塑性の変化に対して変性疾患治療薬が及ぼす影響
Oct. 2015

Transient effects induced by transcranial magnetic quadripulses of the human primary motor cortex
S. J. Groiss; T. Murakami; H. Enomoto; S. Nakatani-Enomoto; S. Kobayashi; A. Yoshihara; K. Nakamura; T. Furubayashi; Y. Sugiura; T. Kujirai; Y. Ugawa
MOVEMENT DISORDERS, May 2014

単相性4連発磁気刺激を用いた下肢運動野皮質興奮性の検討　　　　　　　　　　　　　　　
Dec. 2013

単相性4連発磁気刺激法(QPS)の効果に対する随意運動の影響(第2報)　　　　　　　　　　　　　　　
Dec. 2013

Quadripulse transcranial magnetic stimulation(QPS)の難治性てんかんに対する影響　　　　　　　　　　　　　　　
榎本 雪; 花島 律子; 濱田 雅; 松本 英之; 町井 克行; 寺尾 安生; 川合 謙介; 管 るみ子; 丹羽 慎一; 榎本 博之; 宇川 義一
臨床神経生理学, Oct. 2013
(一社)日本臨床神経生理学会

単相性4連発磁気刺激法(Quadripulse stimulation:QPS)の効果に随意運動が与える影響についての検討(第2報)
Oct. 2013

m.5513 G>A変異を認めたミトコンドリア病の一例　　　　　　　　　　　　　　　
Mar. 2013, [Reviewed]

経頭蓋磁気刺激効果の多チャンネル近赤外線スペクトロスコピー計測システムの開発　　　　　　　　　　　　　　　
Dec. 2012

QPSがミオクローヌスてんかん患者の体性感覚誘発電位に及ぼす影響(第2報)　　　　　　　　　　　　　　　
Dec. 2012

単相性4連発磁気刺激法(QPS)での刺激条件の検討　　　　　　　　　　　　　　　
Dec. 2012

単相性4連発磁気刺激法(Quadripulse stimulation;QPS)の効果に対する随意運動の影響　　　　　　　　　　　　　　　
Dec. 2012

運動野刺激のQPSが感覚皮質に与える影響
Oct. 2012

単相性4連発磁気刺激法(Quadripulse stimulation:QPS)の効果に対する随意運動の影響
Oct. 2012

下肢筋力低下で発症し、急性呼吸不全を呈したmultiminicore disease(MmD)の成人男性の1例　　　　　　　　　　　　　　　
Jul. 2012

The duration of long term potentiation-like plasticity of the human motor cortex induced by patterned monophasic repetitive transcranial magnetic stimulation depends on intra-burst pulse number
S. J. Groiss; H. Mochizuki; H. Enomoto; S. Nakatani-Enomoto; K. Nakamura; A. Yoshihiro; T. Furubayashi; Y. Sugiura; T. Kujirai; Y. Ugawa
MOVEMENT DISORDERS, Jun. 2012

反復単相性4連発磁気刺激法を用いたパーキンソン病の運動野皮質興奮性変化の検討　　　　　　　　　　　　　　　
Dec. 2011

単相性4連発磁気刺激法(Quadripulse stimulation;QPS)における刺激条件の検討　　　　　　　　　　　　　　　
Dec. 2011

単相性4連発磁気刺激法が刺激直下の脳血流に与える影響の検討　　　　　　　　　　　　　　　
Oct. 2011

4連発磁気刺激法(Quadripulse stimulation;QPS)の刺激条件の検討
Oct. 2011

Intrinsic rhythm of the primary motor cortex in cortical myoclonus
R. Hanajima; Y. Terao; S. Nakatani-Enomoto; S. Okabe; Y. Shirota; S. Ohminami; H. Matsumoto; R. Tsutsumi; S. Tsuji; Y. Ugawa
MOVEMENT DISORDERS, May 2011

後天性脱髄性末梢神経障害の馬尾伝導時間　　　　　　　　　　　　　　　
Dec. 2010

腎不全患者でセフェピム塩酸塩投与下に生じた不随意運動と脳波所見　　　　　　　　　　　　　　　
Dec. 2010

Quadripulse transcranial magnetic stimulation can produce neuroplasticity
Setsu Nakatani-Enomoto; Yoshikazu Ugawa
NEUROSCIENCE RESEARCH, 2010

腰仙部磁気刺激専用コイルによる神経根刺激法　　　　　　　　　　　　　　　
Dec. 2009

Lack of facilitation by a triad-conditioned TMS at 40Hz in PD
R. Hanajima; Y. Terao; S. Okabe; S. Nakatani-Enomoto; T. Furubayashi; M. Hamada; A. Yugeta; H. Matsumoto; S. Tsuji; Y. Ugawa
MOVEMENT DISORDERS, 2009

二発脳幹磁気刺激法　　　　　　　　　　　　　　　
Dec. 2008

球脊髄性筋萎縮症(Spinal and Bulbar Muscular Atrophy:SMBA)の手指振戦　　　　　　　　　　　　　　　
Dec. 2008

Magnetic brainstem stimulation using double stimuli in healthy volunteers and patients with pyramidal tract lesions
H. Matsumoto; R. Hanajima; M. Hamada; Y. Terao; A. Yugeta; S. Inomata-Terada; S. Nakatani-Enomoto; Y. Ugawa
MOVEMENT DISORDERS, 2008

浸潤性胸腺腫を伴ったStiff‐person症候群の一例
萩原宏毅; 榎本(中谷)雪; 坂井克之; 宇川義一; 楠進
臨床神経学, 01 Mar. 2000

臨床神経生理検査入門　　　　　　　　　　　　　　　
Joint work
2017

てんかんテキスト New Version (アクチュアル 脳・神経疾患の臨床)　　　　　　　　　　　　　　　
Joint work
23 May 2012
9784521734408

接触電流の感覚閾値の周波数依存性に関する定量的検討　　　　　　　　　　　　　　　
榎本雪; 山崎まどか; 上村佳嗣; 和氣加奈子; 宇川義一
第46回日本臨床神経生理学会学術大会, 29 Oct. 2016

接触電流の感覚閾値の周波数依存性に関する定量的検討　　　　　　　　　　　　　　　
29 Oct. 2016

Quadripulse transcranial magnetic stimulation (QPS) – heterotopic effect on somatosensory evoked potential (SEP) after QPS over the primary motor cortex　　　　　　　　　　　　　　　
Nalatani-Enomoto S; Ugawa Y
第46回日本臨床神経生理学会学術大会, 27 Oct. 2016, [Invited]

Effects of 1950 MHz W-CDMA-like signal on human spermatozoa　　　　　　　　　　　　　　　
Setsu Nakatani-Enomoto; Miho Okutsu; Satoshi Suzuki; Ryota Suganuma; Keiya Fujimori; Stefan Jun Groiss; Suguru Kadowaki; Hiroyuki Enomoto; Yoshikazu Ugawa
BioEM 2016, 07 Jun. 2016

Stimulation frequency dependency of current perception threshold in Japanese　　　　　　　　　　　　　　　
Kamimura Y; Yamazaki M; Nakatani-Enomoto S; Wake K; Ugawa Y
BioEM 2016, 06 Jun. 2016

Effects of 1950 MHz W-CDMA-like signal on human spermatozoa　　　　　　　　　　　　　　　
NAKATANI-ENOMOTO Setsu
BioEM 2016, 2016

Stimulation frequency dependency of current perception threshold in Japanese　　　　　　　　　　　　　　　
NAKATANI-ENOMOTO Setsu
BioEM 2016, 2016

Effects of 1950 MHz W-CDMA-like signal on human spermatozoa　　　　　　　　　　　　　　　
榎本 雪
BioEM 2016, 2016

QPSがミオクローヌスてんかん患者の体性感覚誘発電位に及ぼす影響（第2報）　　　　　　　　　　　　　　　
24 May 2012

携帯電話の睡眠脳波に与える影響　　　　　　　　　　　　　　　
13 Mar. 2012

下肢筋力低下で発症し、急性呼吸不全を呈したmultiminicore disease（MmD）の成人男性の1例　　　　　　　　　　　　　　　
03 Mar. 2012

破傷風の筋MRI　　　　　　　　　　　　　　　
20 May 2011

Safety of the quadri-pulse transcranial magnetic stimulation (QPS)　　　　　　　　　　　　　　　
Nakatani-Enomoto S; Ugawa Y
第21回磁気刺激の臨床応用と安全性に関する研究会, Nov. 2010

Bidirectional human sensory cortical excitability modulation by quadripulse magnetic stimulation (QPS) of various cortical areas　　　　　　　　　　　　　　　
Setsu Nakatani-Enomoto; Ritstuko Hanajima; Masashi Hamada; Yasuo Terao; Hideyuki Matsumoto; Masaki Hirose; Kochiro Nakamura; Toshiaki Furubayashi; Hitoshi Mochizuki; Hiroyuki Enomoto; Yoshikazu Ugawa
29th International Congress of Clinical Neurophysiology, Oct. 2010

Heterosynaptic LTP/LTD 運動野QPSの感覚野への効果　　　　　　　　　　　　　　　
Mar. 2010

Bidirectional human sensory cortical excitability modulation by quadripulse magnetic stimulation (QPS) applied over primary motor cortex；1st International Workshop on Synapticplasticity: From Bench to Bed Side　　　　　　　　　　　　　　　
Setsu Nakatani-Enomoto; Toshiaki Furubayashi; Hiroyuki Enomoto; Masaki Hirose; Kouichiro Nakamura; Hitosh; i Mochizuki; Yoshikazu Ugawa; Ritsuko Hanajima; Masashi Hamada; Hideyuki Matsumoto; Yasuo Terao
1st International Workshop on Synapticplasticity: From Bench to Bed Side, 2010

Quadripulse transcranial magnetic stimulation can produce neuroplasticity　　　　　　　　　　　　　　　
Setsu Nakatani-Enomoto; Yoshikazu Ugawa
第33回日本神経科学大会, 2010

運動野Quadripulse stimulation(ＱＰＳ)が体性感覚誘発電位に与える影響　　　　　　　　　　　　　　　
2009

Quadripulse stimulation (QPS)の安全性に関する検討　　　　　　　　　　　　　　　
2009

亜急性の失調性歩行と認知機能障害を認めたビタミンB1欠乏の75歳男性　　　　　　　　　　　　　　　
2009

QPSがミオクローヌスてんかん患者の体性感覚誘発電位に及ぼす影響　　　　　　　　　　　　　　　
2009

運動前野小梗塞によるataxic monoparesisの1例　　　　　　　　　　　　　　　
2009

シクロスポリン投与後に持続性部分てんかんを呈した33歳男性　　　　　　　　　　　　　　　
2007

L-DOPAの経口投与は白血球内ROSを低下させる　　　　　　　　　　　　　　　
2007

ヒトヘルペスウイルス6型の関連した脳炎の1例　　　　　　　　　　　　　　　
2005

パーキンソン病の振戦に対するレボドパの内服効果の検討　　　　　　　　　　　　　　　
2004

パーキンソン病ならびに本態性振戦における振戦の検討　　　　　　　　　　　　　　　
2004

Double stimulation method of the sensory median nerve of the diabetes mellitus　　　　　　　　　　　　　　　
Setsu Nakatani Enomoto; Mitsuaki Bandou; Hiroshi Nagura; Hiroshi Yamanouchi (Department of Neurology; Tokyo Metropolitan Geriatric Hospital)Yoshikazu Ugawa
その他の会議, 2001

正中神経2発刺激を用いた糖尿病患者の電気生理学的検討　　　　　　　　　　　　　　　
2001

ALS在宅療養における不完全急性腸閉塞　　　　　　　　　　　　　　　
1999

長期療養ALS患者における重篤な合併症：特に不完全腸閉塞の病態　　　　　　　　　　　　　　　
1999

振戦(Tremor)の記録・解析システムの考案　　　　　　　　　　　　　　　
1996

断綴性言語のみを呈した中脳梗塞の１例　　　　　　　　　　　　　　　
1996

不均一連発磁気刺激のてんかんに対する臨床応用およびその生理学的検討　　　　　　　　　　　　　　　
2009 - Present