Naho Maruyama
| Faculty of Health and Medical Science,Department of Health and Dietetics | Professor |
| Graduate School of Health Sciences,Doctoral Program in Health Sciences | Professor |
| Graduate School of Health Sciences,Master's and Doctoral Programs in Health and Dietetics | Professor |
Last Updated :2025/10/07
■Researcher basic information
Field Of Study
■Career
Career
Educational Background
■Research activity information
Paper
- A human-relevant alternative infection model for mucormycosis using the silkworm Bombyx mori
Masaki Ishii; Kazuhiro Mikami; Fumiaki Tabuchi; Naho Maruyama; Atsushi Miyashita
PLOS One, 25 Sep. 2025, [Reviewed]
Mucorales fungi cause life-threatening mucormycosis in patients with clinical risk factors, such as immunodeficiency. Moreover, they are resistant to several antifungal drugs, highlighting the urgent need for novel therapies. Traditional mammalian models are expensive and raise ethical concerns, thereby limiting their suitability for large-scale studies. We established a silkworm (Bombyx mori) infection model to investigate the pathogenicity of Mucorales and evaluated its relevance to human infection. Strains of Rhizopus arrhizus, Mucor circinelloides, and Cunninghamella bertholletiae induced fatal infections in the silkworm. Grocott-stained silkworm tissue sections revealed hyphal invasion patterns closely resembling those observed in human mucormycosis. In addition, experimental simulation of clinical risk factors (steroid use and iron overload) significantly reduced the median lethal dose (LD50). Treatment with the antifungal drug isavuconazonium prolonged the survival of R. arrhizus-infected silkworms, suggesting the potential use of this model for novel antifungal screening. LD50 estimation for four R. arrhizus strains revealed up to a 100-fold difference in pathogenicity to the silkworm among the tested strains, corresponding to variations in cell surface characteristics. Interestingly, the presence of high-molecular weight (50–100 kDa) cell surface proteins was associated with high pathogenicity among R. arrhizus strains. In conclusion, the silkworm is a viable, human-relevant alternative model to investigate Mucorales infections, with potential for large-scale antimucormycosis drug screening. - The pharmacological effects of perilla, which has supported the health of Japanese people, and its future development potential
Sanae A Ishijima; Naho Maruyama
Medical Mycology Research, Dec. 2024, [Reviewed] - Pharmacological effects of tea tree essential oil
Naho Maruyama; Sanae A Ishijima
Medical Mycology Research, Dec. 2024, [Reviewed] - Composition and pharmacological effects, including antibacterial and antifungal properties, of the essential oil from the Japanese endemic Hiba (Asunaro, Thujopsis dolabrata Sieb.et Zucc.).
Sanae A Ishijima; Naho Maruyama; Mitsuyoshi Yatagai
Medical Mycology Research, Dec. 2023, [Reviewed] - Pharmacologycal effects of rose;essential oil;absolute;rose water
Naho Maruyama; Sanae A Ishijima
Medical Mycology Research, Dec. 2023 - 抗菌アロマセラピー 植物精油の紹介－2 レモングラス精油の抗菌・抗真菌効果を含む薬理効果の解析と応用
Dec. 2022, [Reviewed] - 抗菌アロマセラピー 植物精油の紹介－1 ゼラニウム精油の抗感染・抗炎症作用を中心とした薬理作用
Dec. 2022, [Reviewed] - 靴内部に残存する白癬菌等の汚染菌を抗菌する植物精油の選択と抗菌条件の検討
石島 早苗; 江澤 邦夫; 高橋 美貴; 丸山 奈保; 安部 茂
日本防菌防黴学会誌, Oct. 2018, [Reviewed] - 中強度の運動後の若い女性から採取した末梢血好中球の活性化反応に及ぼすローズウォーターの抑制作用
丸山 奈保; 島崎 直樹; 下村 一之; 安部 茂
Aroma Research, Aug. 2018, [Reviewed] - Inhibitory Activity to Neutrophil Adhesion and Antimicrobial Activity of Diluted Hydrosol Prepared from Rosa damascena (vol 40, pg 161, 2017)
Naho Maruyama; Shigeru Tansho-Nagakawa; Chizuru Miyazaki; Kazuyuki Shimomura; Yasuo Ono; Shigeru Abe
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Apr. 2017 - Inhibition of Neutrophil Adhesion and Antimicrobial Activity by Diluted Hydrosol Prepared from Rosa damascena
Naho Maruyama; Shigeru Tansho-Nagakawa; Chizuru Miyazaki; Kazuyuki Shimomura; Yasuo Ono; Shigeru Abe
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Feb. 2017, [Reviewed] - Candida albicans adheres to chitin by recognizing N-acetylglucosamine (GlcNAc)
Sanae A. Ishijima; Tsuyoshi Yamada; Naho Maruyama; Shigeru Abe
Medical Mycology Journal, 2017, [Reviewed] - in vitro爪白癬モデルを用いた白癬菌の発育および爪組織内への侵入過程に関する走査電子顕微鏡解析
西山 彌生; 高橋 美貴; 丸山 奈保; 山田 剛; 安部 茂
Medical Mycology Research, Dec. 2016, [Reviewed] - Suppression of Inflammatory Reactions by Terpinen-4-ol, a Main Constituent of Tea Tree Oil, in a Murine Model of Oral Candidiasis and Its Suppressive Activity to Cytokine Production of Macrophages in Vitro
Kentaro Ninomiya; Kazumi Hayama; Sanae A. Ishijima; Naho Maruyana; Hiroshi Irie; Junichi Kurihara; Shigeru Abe
BIOLOGICAL & PHARMACEUTICAL BULLETIN, May 2013, [Reviewed] - Cell preparation method with trypsin digestion for counting of colony forming units in Candida albicans-infected mucosal tissues
Kazumi Hayama; Naho Maruyama; Shigeru Abe
MEDICAL MYCOLOGY, Nov. 2012, [Reviewed] - The Essential Oil of Melaleuca alternifolia (Tea Tree Oil) and Its Main Component, Terpinen-4-ol Protect Mice from Experimental Oral Candidiasis
Kentaro Ninomiya; Naho Maruyama; Shigeharu Inoue; Hiroko Ishibashi; Toshio Takizawa; Haruyuki Oshima; Shigeru Abe
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Jun. 2012, [Reviewed] - 口腔カンジダ症に対して改善効果が期待される機能食品
安部 茂; 二宮 健太郎; 石島 早苗; 高橋 美貴; 丸山 奈保; 羽山 和美
Medical Mycology Research, Dec. 2011 - 抗真菌薬リラナフタートは抗炎症効果を示す
Feb. 2010 - Suppression of anti-Candida activity of macrophages by a quorum-sensing molecule, farnesol, through induction of oxidative stress
Shigeru Abe; Rumi Tsunashima; Ryosuke Iijima; Tsuyoshi Yamada; Naho Maruyama; Tatsuya Hisajima; Yoshie Abe; Haruyuki Oshima; Masatoshi Yamazaki
MICROBIOLOGY AND IMMUNOLOGY, Jun. 2009, [Reviewed] - Protective activity of geranium oil and its component, geraniol, in combination with vaginal washing against vaginal candidiasis in mice
Naho Maruyama; Toshio Takizawa; Hiroko Ishibashi; Tatsuya Hisajima; Shigeharu Inouye; Hideyo Yamaguchi; Shigeru Abe
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Aug. 2008, [Reviewed] - Protective effects of farnesol against oral candidiasis in mice
Tatsuya Hisajima; Naho Maruyama; Yuko Tanabe; Hiroko Ishibashi; Tsuyoshi Yamada; Koichi Makimura; Yayoi Nishiyama; Kengo Funakoshi; Haruyuki Oshima; Shigeru Abe
MICROBIOLOGY AND IMMUNOLOGY, Jul. 2008, [Reviewed] - A novel murine model of pharyngeal candidiasis with local symptoms characteristic of pharyngeal thrush produced by using an inhaled corticosteroid
Weimin Hu; Kentaro Ninomiya; Hiroko Ishibashi; Naho Maruyama; Haruyuki Oshima; Hideyo Yamaguchi; Shigeru Abe
MEDICAL MYCOLOGY, 2007, [Reviewed] - A novel method to estimate the contribution of the vapor activity of essential oils in agar diffusion assay
Shigeharu Inouye; Katsuhisa Uchida; Naho Maruyama; Hideyo Yamaguchi; Shigeru Abe
Japanese Journal of Medical Mycology, Jun. 2006, [Reviewed] - Suppression of carrageenan- and collagen II-induced inflammation in mice by geranium oil
Naho Maruyama; Hiroko Ishibashi; Weimin Hu; Shinichiro Morofuji; Shigeharu Inouye; Hideyo Yamaguchi; Shigeru Abe
MEDIATORS OF INFLAMMATION, 2006, [Reviewed] - Suppression of neutrophil accumulation in mice by cutaneous application of geranium essential oil
Naho Maruyama; Yuka Sekimoto; Hiroko Ishibashi; Shigeharu Inouye; Haruyuki Oshima; Hideyo Yamaguchi; Shigeru Abe
Journal of Inflammation, 10 Feb. 2005, [Reviewed] - Suppression of neutrophil recruitment in mice by geranium essential oil
S Abe; N Maruyama; K Hayama; S Inouye; H Oshima; H Yamaguchi
MEDIATORS OF INFLAMMATION, Feb. 2004, [Reviewed] - Suppression of tumor necrosis factor-alpha-induced neutrophil adherence responses by essential oils
S Abe; N Maruyama; K Hayama; H Ishibashi; S Inoue; H Oshima; H Yamaguchi
MEDIATORS OF INFLAMMATION, Dec. 2003, [Reviewed] - Immunological Activation of Macrophages and Lymphocytes in Mice Intraperitoneally Administered with a Phellinus linteus preparation
ISHIBASHI Hiroko; KOMIYA Mayumi; MARUYAMA Naho; ABE Shigeru; YAMAGUCHI Hideyo
31 Jul. 2003 - Anti-Candida albicans Activity of Essential Oils Including Lemongrass (Cymbopogon citratus) Oil and its Component, Citral
Shigeru Abe; Yuichi Sato; Shigeharu Inoue; Hiroko Ishibashi; Naho Maruyama; Toshio Takizawa; Haruyuki Oshima; Hideyo Yamaguchi
Japanese Journal of Medical Mycology, 2003, [Reviewed]
MISC
- 真菌感染が関与する身近な健康トラブルを緩和する植物由来機能素材の開発
Oct. 2021 - 【植物の香りシリーズ…17 ローズ】皮膚の炎症症状緩和へのローズウォーターの可能性
Feb. 2020 - 靴の中の真菌・細菌に対する植物精油を用いた殺菌法の開発
Sep. 2013 - 靴の中の真菌・細菌を植物精油で殺菌する方法の開発
Sep. 2013 - マウス足蹠腫脹反応に対する抗真菌薬リラナフタートの抑制効果
Oct. 2012
Books and other publications
Lectures, oral presentations, etc.
- 自然免疫系を介して感染抵抗性を付与する植物精油の探索
Aug. 2024 - 微生物感染に伴う消化管の炎症応答に対する植物精油の可能性の検討
2022 - アレルギーのメカニズムとアロマの可能性
Dec. 2021 - 消化管感染に伴う炎症応答に対する植物精油の抑制作用
Oct. 2021 - 真菌感染が関与する身近な健康トラブルを緩和する植物由来機能素材の開発
Oct. 2021 - 感染症に対するアロマセラピー ～抗菌作用と抗炎症作用～
Feb. 2021 - Hydrosol prepared from Rosa damascena is a candidate for therapeutic agents against superficial candidiasis
Naho Maruyama; Shigeru Tansho-Nagakawa; Miki Takahashi; Chizuru Miyazaki; Kazuyuki Shimomura; Naoki Shimazaki; Yasuo Ono; Shigeru Abe
ISHAM2018, Jun. 2018 - 運動後女子末梢血中の好中球機能に 及ぼすローズウォーターの作用
2017 - 皮膚感染症に対するローズウォーターの可能性の検討
2016 - 感染に伴う皮膚トラブルに対するローズウォーターの可能性の検討
2016 - マウス口腔カンジダ症に有効な低分子化ポリフェノール含有オーラルケアキャンディの抗炎症効果の検討
2015 - カンジダによる皮膚感染症に対するローズウォーターの可能性の検討
2015 - Candida albicans生菌および加熱死菌体のキチンへの付着能
2015 - 温度が抗真菌剤及び植物精油の抗白癬活性に及ぼす影響
2014 - 白癬菌の組織侵入機序に関与する分子道程の試み
2014 - 植物精油を用いた靴の中の真菌・細菌に対する殺菌法 (2)
2014 - 抗真菌剤及び植物精油の抗白癬活性に対する加温効果の検討
Sep. 2013 - 靴の中の真菌・細菌に対する植物精油を用いた殺菌法の開発
Sep. 2013 - 靴の中の真菌・細菌を植物精油で殺菌する方法の開発
Sep. 2013 - 白癬菌を感染させた爪を用いたパルマローザ油の抗白癬活性
Sep. 2013 - 消化管カンジダ症モデルマウスにおける分泌型IgAに及ぼすAHCCの効果
10 Nov. 2012 - マウス足蹠腫脹反応に対する抗真菌薬リラナフタートの抑制効果
Oct. 2012 - The effects of essential oils on inflammation and superficial mycoses
Naho Maruyama; Shigeru Abe
Botanica2012, Sep. 2012 - Cellular damage of murine macrophages by bioactive compounds secreted from Candida albicans
Naho Maruyama, Kazumi Hayama, Shigeru Abe
ISHAM2012, Jun. 2012 - Analysis of cytokine induction in the tongue tissues of an murine oral candidiasis model in the early infection stage
Masashi Okada; Tatsuya Hisajima; Kazumi Hayama; Sanae A Ishijima; Naho Maruyama; Shigeru Abe
IUMS2011, 2011 - Roles of terpenoid alcohols in host defense against Candida infection
Shigeru Abe; Kentaro Ninomiya; Naho Maruyama; Tatsuya Hisajima; Sanae Ishijima; Kazumi Hayama
IUMS2011, 2011 - Candida albicans cause macrophages damage, through secretion of bioactive compounds.
Naho Maruyama; Kazumi Hayama; Masashi Okada; Shigeru Abe
IUMS2011, 2011 - 抗真菌薬リラナフタートは抗炎症効果を示す
Mar. 2010 - マウス口腔カンジタ症における感染初期宿主応答の解析
2010 - 抗真菌薬リラナフタートのホルボール12ミリスタート13アセタートによる炎症に対する抑制効果
2010 - マクロファージの抗カンジダ活性に対するfarnesolの抑制効果の検討
2009 - Suppression of anti-Candida activity of macrophages by farnesol
Naho Maruyama; Rumi Tsunashima; Ryosuke Iijima; Tsuyoshi Yamada; Tatsuya Hisajima; Yoshie Abe; Haruyuki Oshima; Masatoshi Yamazaki; Shigeru Abe
The International Society for Human and Animal Mycology 2009, 2009 - Candida albicansの粘膜定着の常在化機構とfarnesolの関与
2009 - 粘膜カンジダ症マウスモデルでの十全大補湯の治療効果の検討．
2008 - 十全大補湯の粘膜カンジダ症モデルマウスに対する治療効果の検討
2008 - 膣カンジダ症に対して有効性を示す植物精油投与法の検討
2008 - 29-P2-181 口腔カンジダ症への対処を目的とした抗菌活性を有するハーブ成分含有口腔内フィルム剤の開発(製剤,社会の期待に応える医療薬学を)
01 Sep. 2007 - 膣カンジダ症マウスモデルを用いたアロマセラピーの有効性発現条件の検討
Mar. 2007 - アロマトグラムにおける植物精油の気体の抗白癬菌活性．
2007 - 炎症性疾患に対する植物精油の緩和作用．
2006
