Shinichi Watanabe

Faculty of Pharmaceutical Sciences,Department of Pharmaceutical SciencesProfessor
Graduate School of Pharmaceutical Sciences,Doctoral Program in Pharmaceutical SciencesProfessor
Last Updated :2026/06/09

■Researcher basic information

Degree

  • Ph.D., Chiba University

Research Keyword

  • Social Pharmacy
  • Pharmaceutical Information
  • Pharmaceutical Administration

Field Of Study

  • Life sciences, Clinical pharmacy

■Research activity information

Paper

  • Contributions of pharmaceutical interventions to the multidisciplinary dysphagia team: A retrospective observational study.
    Akihito Ueda; Michiko Obara; Shinichi Watanabe
    Journal of pharmaceutical health care and sciences, 05 Aug. 2025
    BACKGROUND: The 2022 revision of Japanese healthcare reimbursement removed pharmacists from the mandatory dysphagia team, despite emerging evidence of medication-related swallowing complications. Our previous pharmacovigilance analysis identified dopamine-blocking drugs as primary contributors to the risk of aspiration pneumonia. This study aimed to validate these findings through a clinical examination of pharmaceutical interventions performed by a multidisciplinary dysphagia team. METHODS: This retrospective observational study was conducted at a 97-bed community hospital in Osaka, Japan, from June 2023 to January 2024. All adult patients with suspected dysphagia who underwent a multidisciplinary team intervention were included in our analysis. Pharmaceutical intervention was requested when medication-related dysphagia or swallowing difficulties were suspected, with interventions classified into the following four categories: drug-induced dysphagia management, dosage form optimization, swallowing aid utilization, and medication burden reduction. Changes in the medication burden were analyzed using paired t-tests. RESULTS: Among 59 patients with dysphagia (mean age, 81.1 ± 9.8 years; 33 males [55.9%], 26 females [44.1%]), 13 (22.0%) underwent pharmaceutical interventions. Drug-induced dysphagia management was the most common intervention (69.2%), targeting dopamine antagonists (sulpiride, risperidone, tiapride, and domperidone), benzodiazepines, and anticholinergics without dopamine-blocking effects. Suspected drug-induced dysphagia was the most common symptom among patients with dementia (38.9%). The intervention group showed a significant reduction in medication (mean, -3.2 medications; P < 0.001), whereas the non-intervention group showed no change. Among the non-intervention group, potential opportunities for the optimization of angiotensin-converting enzyme inhibitors were identified in antihypertensive therapy. CONCLUSIONS: Pharmaceutical interventions may offer clinically meaningful contributions when utilized for patients with dysphagia, supporting the relevance of pharmacovigilance regarding the risks of dopamine antagonists. The findings of this study suggest the importance of reinstating pharmaceutical expertise to multidisciplinary dysphagia teams, as pharmacists provide clinically significant medication optimization, including identifying additional optimization opportunities through systematic medication reviews among vulnerable populations.
    DOI URL
  • Analysis of anticholinergic drugs associated with aspiration pneumonia using the Japanese adverse drug event report database: Supplementary insights from a scoping review
    Akihito Ueda; Kanji Nohara; Michiko Obara; Shinichi Watanabe
    Respiratory Investigation, Nov. 2024, [Reviewed]
    DOI URL
  • Administration of magnesium oxide tablets to an old patient with dysphagia using yogurt as a swallowing aid: a case report　　　　　　　　　　　　　　　
    Akihito Ueda; Nami Fujii; Kanji Nohara; Yoshiyuki Tabata; Shinichi Watanabe; Michiko Obara; Takashi Tomita
    Pharmacometrics, Apr. 2024, [Reviewed]
  • A case of patient with dysphagia experienced separation of tablet from deglutition aid jelly in the larynx　　　　　　　　　　　　　　　
    Shinya Sugiura; Akihito Ueda; Nami Fujii; Kanji Nohara; Shinichi Watanabe; Michiko Obara; Takashi Tomita
    Pharmacometrics, Apr. 2023, [Reviewed]
  • Relationship between the Experience of Obtaining Information about the Side Effects of Anticancer Drugs and Self-regulation of Medication in Cancer Patients
    Tomoki Kumagai; Shinichi Watanabe; Naoko Hayashi; Hiroki Iwata; Noriko Kobayashi; Kazuko Fujimoto; Katsunori Yamaura
    Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences), 10 Nov. 2020, [Reviewed]
    URLDOI URL
  • Survey of Satisfaction and Needs for Provision of Information on Prescription Drugs
    Kento Arakawa; Shinichi Watanabe; Naoko Hayashi; Hiroki Iwata; Noriko Kobayashi; Kazuko Fujimoto; Katsunori Yamaura
    Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences), 10 Nov. 2020, [Reviewed]
    URLDOI URL
  • Estimation of Polyamine Distribution and Polyamine Stimulation of Protein Synthesis in Escherichia coli
    S. Miyamoto; K. Kashiwagi; K. Ito; S. Watanabe; K. Igarashi
    Archives of Biochemistry and Biophysics, Jan. 1993, [Reviewed]
    DOI URL
  • Estimation of polyamine binding to macromolecules and ATP in bovine lymphocytes and rat liver　　　　　　　　　　　　　　　
    S Watanabe; K Kusama-Eguchi; H Kobayashi; K Igarashi
    Journal of Biological Chemistry, Nov. 1991, [Reviewed]

MISC

Books and other publications

Lectures, oral presentations, etc.

Research Themes

  • 課徴金制度の導入等の医薬品等の広告規制の変化を踏まえた実態調査研究
    Apr. 2022 - Mar. 2025
  • 在宅医療における薬剤師と関係職種の連携の実態把握及び推進のための調査研究　　　　　　　　　　　　　　　
    Jul. 2023 - Mar. 2024
  • Research on the Revision of Qualification Requirements for the Marketing Supervisor General of Medical Devices　　　　　　　　　　　　　　　
    Teikyo Heisei University
    Apr. 2022 - Mar. 2023
  • 医療用医薬品の広告監視モニター事業の全施設対応化に伴う普及啓発及び質の向上に関する研究　　　　　　　　　　　　　　　
    Apr. 2020 - Mar. 2022
  • 医療機器の危害防止措置の適切な実施に係るガイダンスに関する研究　　　　　　　　　　　　　　　
    Apr. 2019 - Mar. 2022
  • 「医療用医薬品の販売に係る情報提供ガイドライン」の施行に伴う企業側実体の調査研究
    Apr. 2019 - Mar. 2022
  • 医療用医薬品の適応外使用に係る情報提供の現状把握とガイドライン作成のための調査研究　　　　　　　　　　　　　　　
    2018 - Mar. 2019

■University education and qualification information

Qualifications, licenses

  • 01 Jan. 1996
    Pharmacist
  • 01 Apr. 2006
    Education System Qualified Pharmacist, Japan Pharmacists Education Center
  • 01 Apr. 2012
    Certified Sports Pharmacist, Japan Anti-Doping Agency