Hirotomo Ten
| Faculty of Health Care,Department of Judo Physical Therapy | Professor |
| Graduate School of Health Sciences,Doctoral Program in Health Sciences | Professor |
| Graduate School of Health Sciences,Master's and Doctoral Programs in Judo Physical Therapy | Professor |
Last Updated :2025/10/07
■Researcher basic information
■Career
Career
- May 2023 - Present
Teikyo University, Department of Neurosurgery, Teikyo University Hospital, Visiting Associate Professor - Apr. 2023 - Present
Teikyo Heisei University, Master's Program in Judo Physical Therapy,Graduate School of Health Sciences, Chair - Sep. 2021 - Present
Teikyo Heisei University, Graduate School of Health Science, Professor. - Sep. 2021 - Present
Teikyo Heisei University, Faculty of Health Care Department of Judo Physical Therapy, Professor. - Apr. 2018 - Present
Teikyo Junior College, Part-time Lecturer - Apr. 2020 - Apr. 2023
Teikyo University, Department of Neurosurgery, Teikyo University Hospital, Guest Lecturer - Apr. 2016 - Aug. 2021
Teikyo Heisei University, Graduate School of Health Science, Associate Professor. - Apr. 2016 - Aug. 2021
Teikyo Heisei University, Faculty of Health Care Department of Judo Physical Therapy, Associate Professor. - Apr. 2016 - Mar. 2020
Teikyo University, Department of Neurosurgery, Teikyo University Hospital, Part-time Lecturer - Apr. 2011 - Mar. 2016
Nippon Medical School, department of neurosurgery, assistant professor
Educational Background
Member History
■Research activity information
Paper
- Topical Skin Application of Small-Molecule Antiplatelet Agent against Pressure Injury in Rat Models.
Yuan Yuan; En Takashi; Ping Hou; Akio Kamijo; Daiji Miura; Hirotomo Ten
International journal of molecular sciences, 29 Jan. 2024, [Reviewed] - Fluctuations in Detection Indicators and Their Significance for the Diagnosis of Early Pressure Injury in Rat Models
Ping Hou; Lu Chen; En Takashi; Akio Kamijo; Huiwen Xu; Daiji Miura; Hirotomo Ten; Akio Kitayama; Jianglin Fan
JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING, Jan. 2024, [Reviewed] - A comprehensive analysis of multi-circulatory disorders in early pressure injury and their diagnostic significance in rat models
Lu Chen; En Takashi; Akio Kamijo; Daiji Miura; Jian Lu; Lan Zhang; Hirotomo Ten; Jianglin Fan
Scientific Reports, 07 Nov. 2023, [Reviewed] - Sequential expression of miR-221-3p and miR-338-3p in Schwann cells as a therapeutic strategy to promote nerve regeneration and functional recovery.
Li-Li Wen; Tian-Hao Yu; Yi-Zhan Ma; Xiao-Yan Mao; Tian-Rang Ao; Rabia Javed; Hirotomo Ten; Akira Matsuno; Qiang Ao
Neural regeneration research, Mar. 2023, [Reviewed] - Cathepsin D Inhibits Angiogenesis in Pituitary Neuroendocrine Tumors.
Ren Fujiwara; Hirotomo Ten; Hui Chen; Chuan-Lu Jiang; Ken-Ichi Oyama; Keisuke Onoda; Akira Matsuno
Acta histochemica et cytochemica, 28 Dec. 2022, [Reviewed] - Role of Bone Metabolic Marker Proteins in Calcified Lesions of Carotid Arteriosclerosis
Yu Hirokawa; Hirotomo Ten; Keisuke Onoda; Akira Matsuno
Acta Scientific Neurology, 01 Dec. 2022, [Reviewed] - Evaluation of the malignant potential of gliomas using diffusion-weighted and gadolinium-enhanced magnetic resonance imaging
Yoshinori Takaya; Hui Chen; Hirotomo TEN; Katsumi Hoya; Chuan-lu Jiang; Ken-ichi Oyama; Keisuke Onoda; Akira Matsuno
Brain Science Advances, Dec. 2021, [Reviewed]
Objective:
This study aimed to determine whether the apparent diffusion coefficients (ADCs) determined by diffusion-weighted imaging (DWI) of magnetic resonance imaging (MRI) could facilitate the malignancy grading of various gliomas.
Methods:
Sixty patients with a primary cerebral glioma underwent diffusion-weighted and gadolinium-enhanced (Gd) T1-weighted MRI using a 1.5-T MRI scanner. Scoring was performed based on signal intensities on DWI and Gd images. The mean and minimum ADC values were calculated, and Ki-67 staining was performed for each histological sample to evaluate their tumor proliferative potential. Then, the DWI, Gd, and combined scores were analyzed and compared with the Ki-67 staining index and malignant grade. The relationships among the mean and minimum ADC values, Ki-67 staining index, and malignant grade were also evaluated.
Results:
The minimum ADC was inversely correlated with the Ki-67 staining index, with a low minimum ADC suggestive of tumor malignancy. The qualitative evaluation of the D score of water molecule diffusion on DWI accurately reflected the pathological grades of gliomas, with an effectiveness that was at least as good as the quantitative analysis using the minimum ADC. The diagnostic value of Gd images in determining glioma malignancy grades was inferior to that of DWI.
Conclusion:
Both DWI and gadolinium-enhanced images of MRI should be considered essential for the diagnosis of tumor malignancy. - Fibrin Glue/Fibronectin/Heparin-Based Delivery System of BMP2 Induces Osteogenesis in MC3T3-E1 Cells and Bone Formation in Rat Calvarial Critical-Sized Defects.
Qiang Ao; Shilin Wang; Qing He; Hirotomo Ten; Kenichi Oyama; Akihiro Ito; Jing He; Rabia Javed; Aijun Wang; Akira Matsuno
ACS applied materials & interfaces, 18 Mar. 2020, [Reviewed] - Fabrication and Evaluation of a Xenogeneic Decellularized Nerve-Derived Material: Preclinical Studies of a New Strategy for Nerve Repair.
Ting Li; Zhigang Sui; Akira Matsuno; Hirotomo Ten; Kenichi Oyama; Akihiro Ito; Hong Jiang; Xiaomin Ren; Rabia Javed; Lihua Zhang; Qiang Ao
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, Jan. 2020, [Reviewed] - Occipital lobe epilepsy was presented in a patient with intracerebral schwannoma: a case report and literature review.
Hirotomo Ten; Koji Adachi; Fumio Yamaguchi; Akira Matsuno; Akira Teramoto; Akio Morita
The International journal of neuroscience, Mar. 2019, [Reviewed] - An intraoperative motor tract positioning method in brain tumor surgery: technical note.
Fumio Yamaguchi; Hirotomo Ten; Tadashi Higuchi; Tomoko Omura; Toyoyuki Kojima; Koji Adachi; Takayuki Kitamura; Shiro Kobayashi; Hiroshi Takahashi; Akira Teramoto; Akio Morita
Journal of neurosurgery, Sep. 2018, [Reviewed] - Hyperthermotherapy enhances antitumor effect of 5-aminolevulinic acid-mediated sonodynamic therapy with activation of caspase-dependent apoptotic pathway in human glioma.
Donghui Ju; Fumio Yamaguchi; Guangzhi Zhan; Tadashi Higuchi; Takayuki Asakura; Akio Morita; Hideo Orimo; Shaoshan Hu
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, Aug. 2016, [Reviewed]
Sonodynamic therapy (SDT) has shown great potential as an approach for cancer treatment, and hyperthermotherapy (HT) is also a promising cancer therapy. Here, we investigate whether HT could improve the efficacy of SDT and to make a preliminary exploration on potential mechanism. Xenograft tumor was established in nude mice model, and SNB19 and U87MG glioma cell lines were utilized for in vitro experiment. Alamar blue assay was performed to assess cell viability. Optical microscope was used to characterize the morphology changes of the glioma cells induced by SDT and HT treatments. Apoptotic rate, mitochondrial membrane potential (MMP), and intracellular production of reactive oxygen species (ROS) were examined by flow cytometer. The cell apoptosis of tumor tissues were detected by TUNEL assay. Furthermore, the expression of apoptosis-related proteins was detected with Western blot in vitro and immunohistochemistry in vivo. SDT plus HT group could significantly reduce the cell viability with circular-cell morphological change, compared with SDT group, and cell viability was decreased depending on raise of 5-ALA concentration, ultrasound exposure time, and temperature. The results also indicate that HT increased a conspicuous apoptosis, ROS production, and a remarkable loss in MMP induced by 5-ALA-SDT in vitro. Meanwhile, our data also demonstrated that the combined treatment could significantly induce apoptosis and delay tumor growth in vivo. Furthermore, in both in vitro and in vivo experiments, SDT plus HT group expressed significantly higher protein levels of Bax and cleaved caspase-3, 8, and 9 compared to SDT, HT, and control groups and significantly lower protein level of bcl-2 than the other three groups, while the expression of these proteins was unchanged between HT and control groups. HT may provide an important promotion on 5-ALA-SDT and further propose that SDT in combination with HT is a new potential application for the treatment of human glioma. - Technical Considerations For The Peg Capping Method To Eliminate Csf Loss In The Supine Positioned Dbs Surgery
Ichiro Takumi; Masahiro Mishina; Kouhei Hironaka; Hirotomo Ten; Koji Adachi; Akira Teramoto; Akio Morita
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY, 2013, [Reviewed] - PROTECTION OF MOTOR PATHWAY ADJACENT TO INTRAAXIAL TUMORS BY THE GUIDANCE OF INTRAOPERATIVELY PLACED MARKERS
Fumio Yamaguchi; Tomoko Omura; Hirotomo Ten; Yudo Ishii; Toyoyuki Kojima; Hiroshi Takahashi; Akira Teramoto
NEURO-ONCOLOGY, Nov. 2011, [Reviewed] - Pathological changes of Mangolia gerbil gastric mucosa with long-term exposure to Helicobacter pylori
Jing Chi; Bao-Yu Fu; Min Song; Guang-Zhi Zhan; Li-Bo Wu; T; Hattori
WORLD CHINESE JOURNAL OF DIGESTOLOGY, Dec. 2002, [Reviewed] - Role of p53 in Growth Suppression by Bromodeoxyuridine in Human Gastric Cancer Cell Lines.
Zuan Guang-Zhi; Sugihara Hiroyuki; Peng Dun-Fa; Ling Zhi-Qiang; Yao Xiao-Hong; Yoshitake Kazusada; Hattori Takanori
ACTA HISTOCHEMICA ET CYTOCHEMICA, 2000, [Reviewed]
Bromodeoxyuridine (BrdU) is known to cause base mispairs and DNA strand breaks during DNA synthesis, culminating in growth suppression. To know whether P53 gene plays any role in the BrdU-induced growth suppression, we continuously gave BrdU (20 μM) to the synchronized culture of human gastric cancer cell lines, MKN-45 (P53-wild type) and MKN-28 (P53-mutant), shortly after release from the G1/S block by hydroxyurea. In comparison with the control culture, the growth of MKN-28 was not suppressed until 48 hr of BrdU exposure, while that of MKN-45 was already suppressed at the 24 hr point. Continuous exposure to BrdU caused a S-phase delay and G2 arrest of around 6 hr each in MKN-45 and a delay only of the second S phase in MKN-28 in comparison with synchronized control cultures of matched cell cycle phase. BrdU-exposed MKN-45 cells showed a significantly higher incidence of apoptosis after the cells passed through the first G2 phase and the second S/G2 phases, but MKN-28 did not. It thus appears that the delays of S/G2 phases and an increased incidence of apoptosis in the first cell cycle are p53-dependent. The growth suppression in the second S/G2 phase or later observed in both of the cell lines may be p53-independent.
MISC
- Local skin ventilation reduces pressure injuries in rats through oxygen supply and improving the microclimate
Kamijo Akio; Mao Xin’E; Chen Hongmei; Miura Daiji; Kitayama Akio; Ten Hirotomo; Takashi En
01 Feb. 2025 - 早期褥瘡における病理機序の再考と最新の知見に基づく診断デバイスの開発
Aug. 2024 - 臨床で役立つKneeの伝統技術と最新技術 スポーツによるKneeの外傷と障害
Nov. 2021 - 開頭血腫除去術により良好な予後が得られた深昏睡・両側瞳孔散大の2例
Feb. 2020 - 後頭葉てんかんで発症した、脳実質内神経鞘腫手術例の臨床病理学的検討
May 2013
Lead - 胃癌細胞株におけるBrdUによる細胞死の誘発(2) 同調培養での検討
Mar. 2000
Books and other publications
Lectures, oral presentations, etc.
- Estimation of glioma malignancy using diffusion-weighted imaging and gadolinium enhancement imaging
09 Apr. 2022 - 後頭葉てんかんを呈する脳実質内に発症するシュワン細胞腫の症例報告と 文献レビュー
08 Apr. 2022 - 意識障害に対する東洋医学的アプローチ
03 Apr. 2022, [Invited] - スポーツによる Knee の外傷と障害
14 Nov. 2021, [Invited] - Endoscopic endonasal skull base surgery for invasive pituitary adenomas
15 Oct. 2020 - 開頭血腫除去術により良好な予後が得られた深昏睡・両側瞳孔散大の２例
06 Mar. 2020 - Treatment strategy for the patients with an asymptomatic pituitary tumor
11 Oct. 2019 - Endoscopic surgery for tumors in and around the third ventricle
02 Aug. 2019, [Invited] - 内頸動脈狭窄症に対する頸動脈内膜剥離術の安全性と術後評価についての検討
23 Mar. 2019 - Endoscopic surgery for third ventricle tumors ‒ current activities and future
11 Oct. 2018 - Construction of cloud independent PHR system - Development of multilingual Medical Records smartphone application
11 Oct. 2018 - Brain Mapping for the prevention of functional deterioration by ischemia.
13 Oct. 2017 - Early identification of neural tracts preserves motor and language functions for brain tumor patients.
01 Oct. 2016 - A case of pituitary apoplexy related to LHRH agonist therapy
29 Sep. 2016 - Optic Nerve Glioma Manifesting as Intratumoral Hemorrhage in an adult
15 Oct. 2015 - Intraoperative neural tract positioning for safe tumor surgery
15 Oct. 2015 - Effect of sonodynamic therapy with 5-aminolevulinic acid on malignant glioma
14 Oct. 2015 - Recognition of Neural Tracts in Brain Tumor Surgery for Patients’ Quality of Life and Medical Safety
Fumio Yamaguchi; MD, PhD.; Hirotomo Ten MD, PhD.; Tadashi Higuchi MD; Tomoko Omura; Koji Adachi; Takayuki Kitamura; Akio Morita MD, PhD.
Congress of Neurological Surgeons 2015 Annual Meeting, 30 Sep. 2015 - 錐体路近傍悪性脳腫瘍に対する治療方針
23 Jan. 2015 - A case of repetitive transient ischemic attack associated with left atrial myxoma
15 Oct. 2015 - Ischemic complications associated with resection of intra-axial tumor
11 Oct. 2014 - Neural tract positioning by complementation of multi-modal information
11 Oct. 2014 - The experience of Bevacizmab for patients with primary malignant glioma in our institute
10 Oct. 2014 - PEG capping method in the DBS surgery -technical consideration
09 Oct. 2014 - Pile Driving Techniqueによる神経路温存手術
12 Sep. 2014 - Navigation-assisted subcortical mapping for secure identification of pyramidal tract
12 Jul. 2014 - グリオーマ手術における高輝度 LED レーザー併用 5-ALA 蛍光診断の有用性：病理学的所見の立場．
12 Jul. 2014 - 摘出不能初発膠芽腫に対するベバシズマブ・テモゾロミド併用療法の一例
04 Jul. 2014 - アミノレブリン酸蛍光診断における新規抗てんかん薬の影響に関する検討
28 Jun. 2014 - A case of metastasis to the Meckel's cave biopsied by the endoscopic endonas al transpterygoid approch
19 Jun. 2014 - Comparative study of intraoperative photodynamic diagnosis using 5-aminolevulic acid and pathological
18 Oct. 2013 - 機能温存を最重視したグリオーマ治療戦略
18 Oct. 2013 - intracerebral schwannomaの一例
20 Apr. 2013 - Yamaguchi Grid Electrode; a Grid Electrode with slits for brain surface fitting and easy cortical electrical stimulation
13 Apr. 2013 - 難治性複雑部分発作を呈する側頭葉腫瘍の一手術例
08 Dec. 2012 - 自験例100症例から得られた脳腫瘍手術における 5-ALA蛍光診断についての検討
19 Oct. 2012 - 症候性てんかんを伴う脳腫瘍に対する治療の試み―摘出術におけるMSTの併用―
19 Oct. 2012 - 術中運動誘発電位におけるBIS(Bispectral Index)と F-waveについての検討
19 Oct. 2012 - 脳腫瘍手術における“Real Motor Tract Mapping”
19 Oct. 2012 - 橈骨動脈グラフトを用いた多発内頸動脈瘤による頸動脈-海綿静脈洞 瘻の治療-4D-flow MRIによる脳血流解析を含めて
19 Oct. 2012 - Intraoperative “Real Motor Tract Mapping” for brain tumor surgery
14 Jul. 2012 - 術中ナビゲーションシステム統合トラクトグラフィーのピットフォー ル-NY Tract Finderによる錐体路直接電気刺激による検証
13 Oct. 2011 - 機能温存を目的とした術中錐体路マッピング ―電気生理学的留置マーカーによる3次元的錐体路把握―
13 Oct. 2011 - 当施設における頸椎変性疾患固定術の変遷
12 Oct. 2011 - 脳腫瘍術中蛍光診断における蛍光陽性判定の問題点
14 Nov. 2010 - トラクトグラフィー導入ナビゲーションのpitfall ―NY Tract Finderを用いた術中皮質下マッピングによる錐体路位置 情報の検証―
29 Oct. 2010 - A Case of Intrasellar Chondroma.
11 Sep. 2010
Affiliated academic society
Research Themes
- 人工知能を活用した褥瘡早期自動診断機の製品開発と臨床検証
01 Apr. 2025 - 31 Mar. 2029
■University education and qualification information
