Apr. 2025

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Aug. 2022

Sep. 2019

Jun. 2019

援助希求しない若者が望む支援サービス体制 ―東京都狛江市のオープンデータを用いた横断解析―
Sep. 2025, [Reviewed]

Classroom-Level and Individual-Level Prosociality and Help-Seeking Behaviors Among Adolescents
Ryo Morishima; Satoshi Usami; Akiko Kanehara; Naohiro Okada; Haruko Noguchi; Sho Yagishita; Masato Fukuda; Kiyoto Kasai
JAMA Netw Open, May 2025, [Reviewed]

Physical and psychosocial factors associated with fatigue in individuals with 22q11.2 deletion syndrome
Yusuke Takahashi; Yutaka Sawai; Akito Uno; Miho Tanaka; Akiko Kanehara; Ryo Morishima; Yousuke Kumakura; Ichiro Sakamoto; Sho Yagishita; Seiichiro Jinde; Kiyoto Kasai
Psychiatry and Clinical Neurosciences Reports, 07 Jun. 2024, [Reviewed]
Abstract

Aims

This study investigated fatigue in individuals with 22q11.2 deletion syndrome (22q11.2DS), identifying both physical and psychosocial factors.

Methods

We conducted a cross‐sectional web‐based survey of 125 parents of individuals with 22q11.2DS. Significant factors of fatigue were identified using bivariate analysis and forward stepwise binary logistic regression.

Results

Overall, 34% (42 of 125) of the participants reported fatigue. Bivariate analysis identified 37 variables linked with fatigue, of which 11 were significant in multivariable analysis: older age (odds ratio [OR] = 1.28, 95% confidence interval [CI] [1.07, 1.53], P = 0.008), history of auditory hypersensitivity (OR = 36.4, 95% CI [4.08, 323.8], P = 0.001), delayed motor development (OR = 10.4, 95% CI [1.78, 61.0], P = 0.009), difficulty participating in events (OR = 33.5, 95% CI [1.1, 1068.2], P = 0.047), inability to join groups (OR = 47.9, 95% CI [4.8, 481.7], P = 0.001), concerns about marriage (OR = 17.0, 95% CI [2.6, 112.7], P = 0.003), inability to attend facilities (OR = 20.4, 95% CI [1.4, 308.0], P = 0.029), poor coordination when changing medical facilities (OR = < 0.010, 95% CI [0, 0.014], P = 0.002), lack of understanding about the individual's condition (OR = 0.010, 95% CI [0, 0.502], P = 0.021), and requirement of visiting multiple departments within the hospital (OR = 46.6, 95% CI [1.9, 1124.6], P = 0.018).

Conclusions

Fatigue in 22q11.2DS is multifaceted, necessitating holistic fatigue management.

Long-Term Trends and Sociodemographic Inequalities of Emotional/Behavioral Problems and Poor Help-Seeking in Adolescents During the COVID-19 Pandemic
Ryo Morishima; Akiko Kanehara; Toshiaki Aizawa; Naohiro Okada; Kaori Usui; Haruko Noguchi; Kiyoto Kasai
Journal of Adolescent Health, Nov. 2023, [Reviewed]

Association between Multimorbidity and Quality of Life in 22q11.2 Deletion Syndrome: Cross-section Analysis Using the National Database of Designated Incurable Diseases of Japan
Ryo Morishima; Hayato Yamana; Seiichiro Jinde; Yousuke Kumakura; Akiko Kanehara; Miho Tanaka; Taisuke Jo; Nobuaki Michihata; Kiyoto Kasai
Journal of Health Care and Society, Sep. 2023, [Reviewed]

Relationship between high trait anxiety in 22q11.2 deletion syndrome and the difficulties in medical, welfare, and educational services
Naomi Nakajima; Miho Tanaka; Akiko Kanehara; Ryo Morishima; Yousuke Kumakura; Noriko Ohkouchi; Junko Hamada; Tomoko Ogawa; Hidetaka Tamune; Mutsumi Nakahara; Shunsuke Mori; Kayo Ichihashi; Seiichiro Jinde; Yukiko Kano; Ichiro Sakamoto; Kyoko Tanaka; Yoichiro Hirata; Hirofumi Ohashi; Tokuko Shinohara; Kiyoto Kasai
Psychiatry and Clinical Neurosciences Reports, 13 Feb. 2023, [Reviewed]

Educational challenges for 22q11.2 deletion syndrome in Japan: Findings from a mixed methods survey.
Miho Tanaka; Akiko Kanehara; Ryo Morishima; Yousuke Kumakura; Noriko Okouchi; Naomi Nakajima; Junko Hamada; Tomoko Ogawa; Hidetaka Tamune; Mutsumi Nakahara; Seiichiro Jinde; Yukiko Kano; Kiyoto Kasai
Journal of applied research in intellectual disabilities : JARID, 13 Feb. 2023, [Reviewed]
BACKGROUND: The 22q11.2 deletion syndrome (22q11DS) is characterised by a changing pattern of overlapping intellectual, physical, and mental disabilities along the course of one's life. However, the impact of overlapping disorders (multimorbidity) on educational challenges remains unclear. METHOD: A survey was conducted with 88 caregivers of individuals with 22q11DS. A quantitative analysis of educational challenges and support needs divided into age groups (7-12, 13-15, 16-18, and 19 years and over) and a qualitative analysis of the free-text items in the questionnaire was conducted. RESULTS: Caregivers were more interested in comprehensive developmental support when their children were younger, and the emphasis shifted to concerns regarding environments that matched individual characteristics at older ages. Furthermore, when there are multiple disabilities or disorders, support is concentrated on the more obvious disabilities, and the lack of support for the less superficially obvious disabilities associated with multiple difficulties, including mental health problems, can be a challenge for people with 22q11DS and their families. CONCLUSIONS: This study suggests a need for increased focus on multimorbidity and associated disabilities in school education that are difficult to observe because of their mildness or borderline levels if present alone.

A qualitative study of the difficulties experienced by mothers of children with chromosomal disorder with multiple disabilities in school education
Feb. 2023, [Reviewed]

Welfare System Difficulties and Desired Support for Individuals with 22q11.2 Deletion Syndromes and Their Families : Analysis of Web Survey Results by Mixed Method Research
2023, [Reviewed]

【学校で精神疾患を「自分のこと」として教育する】こころの健康出前授業と,授業教材の作成
Sep. 2022

Young carers in Japan: Reliability and validity testing of the BBC/University of Nottingham young carers survey questionnaire and prevalence estimation in 5000 adolescents
Akiko Kanehara; Ryo Morishima; Yusuke Takahashi; Haruna Koike; Kaori Usui; Shun‐ichi Sato; Akito Uno; Yutaka Sawai; Yousuke Kumakura; Sho Yagishita; Satoshi Usami; Masaya Morita; Kentaro Morita; Sho Kanata; Naohiro Okada; Syudo Yamasaki; Atsushi Nishida; Shuntaro Ando; Shinsuke Koike; Tomoko Shibuya; Stephen Joseph; Kiyoto Kasai
Psychiatry and Clinical Neurosciences Reports, Sep. 2022, [Reviewed]

Sex-based differences in the longitudinal association between autistic traits and positive psychotic experiences in adolescents: A population-based cohort study
Tomoki Kiyono; Shuntaro Ando; Ryo Morishima; Shinya Fujikawa; Sho Kanata; Yuko Morimoto; Kaori Endo; Syudo Yamasaki; Satoshi Usami; Mariko Hiraiwa-Hasegawa; Atsushi Nishida; Kiyoto Kasai
Schizophrenia Research, Aug. 2022, [Reviewed]
Previous reports have suggested a cross-sectional association between autistic traits and psychotic experiences (PEs) in adolescents. However, while both autistic traits and PEs show sex-related differences, no studies have directly assessed whether such differences exist in the longitudinal association between autistic traits and PEs. Using a population-based adolescent cohort sample (n = 3007), we tested whether the longitudinal association between autistic traits and positive PEs was affected by sex-based differences using regression analyses. Autistic traits were assessed at 12 years old (timepoint 1 [T1]), and PEs were assessed at 12 and 14 years old (T1 and T2). Subsequently, we tested whether subdomains of autistic traits (difficulties in social interaction, communication, imagination, attention to detail, and attention switching) were associated with subtypes of PEs (auditory hallucinations, visual hallucinations, and delusions) using structural equation modeling, after controlling for PEs at T1, socio-economic status, school performance and parents' psychiatric disorders. After controlling for PEs at T1, we did not find any associations between autistic traits at T1 and PEs at T2 in both sexes. There was no significant positive or negative association between all subdomains of autistic traits and subtypes of PEs in both sexes. Autistic traits do not seem to predict future PEs in general adolescents regardless of sex.

Implementation of online classes during national school closure due to COVID‐19 and mental health symptoms of adolescents: A cross‐sectional survey of 5000 students
Ryo Morishima; Haruna Koike; Akiko Kanehara; Kaori Usui; Naohiro Okada; Shuntaro Ando; Kiyoto Kasai
Psychiatry and Clinical Neurosciences Reports, Jun. 2022, [Reviewed]
AIM: Online classes were implemented in numerous schools during the school closure due to COVID-19. The present study examined the relationship between online classes during national school closure and mental health symptoms after the reopening of schools. METHODS: We conducted a cross-sectional survey from October 1 to November 7, 2020 using an anonymous self-reported questionnaire to evaluate 21 junior and senior high schools in the Saitama prefecture of Japan. Out of the 5538 students who were recruited, 5000 agreed to participate. The relationship between the implementation of online classes and mental health symptoms (emotional symptoms, psychotic experience [PE], and smartphone addiction) was evaluated using mixed-effect logistic regression models, while controlling for individual and class-level covariates (e.g., gender, grades). RESULTS: Implementation of online classes was reported by 78.2% of classroom teachers, and it was associated with lower rates of emotional symptoms (OR = 0.79, 95% CI = 0.63-0.99, p = 0.040) and smartphone addiction (OR = 0.79, 95% CI = 0.65-0.96, p = 0.020), but not related to PE (OR = 0.91, 95% CI = 0.61-1.36, p = 0.637). CONCLUSIONS: Implementing online classes during the national school closure might have had a potential protective effect for adolescents' mental health symptoms (especially emotional symptoms and smartphone addiction) after the reopening of schools during the ongoing COVID-19 pandemic.

Trajectory and course of problematic alcohol use after the Great East Japan Earthquake: Eight‐year follow‐up of Higashi‐Matsushima cohort study
Ryo Morishima; Satoshi Usami; Shuntaro Ando; Tomoki Kiyono; Masaya Morita; Shinya Fujikawa; Tsuyoshi Araki; Kiyoto Kasai
Alcoholism: Clinical and Experimental Research, 31 Jan. 2022, [Reviewed]
BACKGROUND: Problematic alcohol use (PAU) after natural disasters is an unignorable public health issue. However, the long-term trajectory and course of PAU after an earthquake disaster remain unknown. METHODS: The Higashi-Matsushima cohort study was conducted between 2012 (time 1) and 2019 (time 8) in areas affected by the Great East Japan Earthquake in 2011. In the annual health checks, participants responded to self-report questionnaires on PAU, traumatic experiences (e.g., house damage), resources (e.g., social support), and other covariates (e.g., gender, psychological distress). The trajectory and course of PAU were estimated by latent growth model and latent class analyses. Risk factors for the long-term course of PAU were calculated by multinomial logistic regression analysis with multiple imputation. The analytical sample comprised 8929 residents who participated in at least one survey across the eight time points. RESULTS: The trajectory of PAU showed a sustained trend (slope <0.001). Three potential courses of PAU (No PAU course: 84.3%, Subthreshold PAU course: 12.4%, and Persistent PAU course: 3.4%) were estimated. The long-term course of PAU, especially the persistent PAU course, was predicted by house damage (OR = 1.43, 95% CI 1.06 to 1.92), less social support (OR = 0.71, 95% CI 0.53 to 0.96), gender (male) (OR = 16.86, 95% CI 9.42 to 30.20), and psychological distress (OR = 1.15, 95% CI 1.09 to 1.20). CONCLUSIONS: Long-term support is needed after an earthquake disaster, especially for residents who in early phases of the disaster suffer from PAU, males, and those in vulnerable situations resulting from conditions such as severe house damage, low social support, or high psychological distress.

Medical, welfare, and educational challenges and psychological distress in parents caring for an individual with 22q11.2 deletion syndrome: A cross‐sectional survey in Japan
Ryo Morishima; Yousuke Kumakura; Satoshi Usami; Akiko Kanehara; Miho Tanaka; Noriko Okochi; Naomi Nakajima; Junko Hamada; Tomoko Ogawa; Shuntaro Ando; Hidetaka Tamune; Mutsumi Nakahara; Seiichiro Jinde; Yukiko Kano; Kyoko Tanaka; Yoichiro Hirata; Akira Oka; Kiyoto Kasai
American Journal of Medical Genetics Part A, Jan. 2022, [Reviewed]
Parents of children with 22q11.2 deletion syndrome (22q11DS) experience distress not only due to multimorbidity in the patients, but also due to professionals' lack of understanding about 22q11DS and insufficient support systems. This study investigated relationships between medical, welfare, and educational challenges and parental psychological distress. A cross-sectional survey was conducted on primary caregivers of children with 22q11DS. Participants included 125 parents (114 mothers, 91.2%; average age = 44.3 years) who reported their challenges, psychological distress, and child's comorbidities of 22q11DS. Results showed that the difficulty in going to multiple medical institutions (β = 0.181, p < 0.05) and lack of understanding by welfare staff and insufficient welfare support systems for 22q11DS (β = 0.220-0.316, all p < 0.05) were associated with parental psychological distress, even after adjusting for child's comorbidities. In the subsample of parents whose child attended an educational institution, inadequate management in classroom and mismatch between service and users in educational settings were associated with psychological distress (β = 0.222-0.296, all p < 0.05). This study reveals the importance of assessing not only severity of comorbidities in 22q11DS, but also the medical, welfare, and educational challenges for parental mental health.

Bidirectional relationship of problematic Internet use with hyperactivity/inattention and depressive symptoms in adolescents: a population-based cohort study
Masaya Morita; Shuntaro Ando; Tomoki Kiyono; Ryo Morishima; Tomoko Yagi; Sho Kanata; Shinya Fujikawa; Syudo Yamasaki; Atsushi Nishida; Kiyoto Kasai
European Child & Adolescent Psychiatry, 22 May 2021, [Reviewed]
Problematic Internet use (PIU), hyperactivity/inattention, and depressive symptoms are comorbid problems in adolescence, but the causal relationships among these issues are unclear. To assess the relationships among PIU, hyperactivity/inattention, and depressive symptoms in adolescents in the general population. This longitudinal cohort study used data from the Tokyo Teen Cohort study in Tokyo, Japan, for two years between October 2012 and January 2015. Of the 3171 pairs of children and parents, 3007 pairs continued to participate in the second wave of the Tokyo Teen Cohort study. A total of 3007 children were included in the analysis (mean [standard deviation] age, 9.7 [0.4] years; 1418 women [47.2%]. Cross-lagged panel analysis revealed that PIU at timepoint 1 was significantly associated with hyperactivity/inattention at timepoint 2 (β = 0.03; 95% confidence interval (CI) 0.01–0.06), and hyperactivity/inattention at timepoint 1 was also significantly associated with PIU at timepoint 2 (β = 0.07; 95% CI 0.04–0.10), even after adjustments were made for depressive symptoms. Furthermore, PIU at timepoint 1 was significantly associated with depressive symptoms at timepoint 2 (β = 0.05; 95% CI 0.01–0.12), and depressive symptoms at timepoint 1 were also significantly associated with PIU at timepoint 2 (β = 0.05; 95% CI 0.02–0.07), even after adjustments were made for hyperactivity/inattention. These results support the bidirectional relationships among PIU, hyperactivity/inattention, and depressive symptoms. PIU may be a target to improve hyperactivity/inattention and depressive symptoms in adolescents.

Toward co-production of research in 22q11.2 deletion syndrome: research needs from the caregiver’s perspective
Hidetaka Tamune; Yousuke Kumakura; Ryo Morishima; Akiko Kanehara; Miho Tanaka; Noriko Okochi; Naomi Nakajima; Junko Hamada; Tomoko Ogawa; Mutsumi Nakahara; Seiichiro Jinde; Yukiko Kano; Kyoko Tanaka; Yoichiro Hirata; Akira Oka; Kiyoto Kasai
Psychiatry and Clinical Neurosciences, 09 Sep. 2020, [Reviewed]

The Prevalence of Psychotic Experiences in Autism Spectrum Disorder and Autistic Traits: A Systematic Review and Meta-Analysis
Tomoki Kiyono; Masaya Morita; Ryo Morishima; Shinya Fujikawa; Syudo Yamasaki; Atsushi Nishida; Shuntaro Ando; Kiyoto Kasai
Schizophrenia Bulletin Open, 31 Aug. 2020, [Reviewed]

Several reports have highlighted an association between psychotic experiences (PEs) and autism spectrum disorder/autistic traits; however, no systematic review of the evidence has been done. We searched PubMed, PsycINFO, Web of Science, and Cochrane database on November 20, 2018, for studies providing statistical results on the association between PEs and autism spectrum disorder/autistic traits. Meta-analyses were conducted for both the prevalence of PEs in autism spectrum disorder and the correlation coefficients between PEs and autistic traits. Subgroup analyses were conducted for each PE subtype. Among the 17 included studies, 9 had data about prevalence and 8 had data about correlation. Pooled prevalence of PEs in autism spectrum disorder was 24% (95% confidence interval [CI] 14%–34%). However, subanalyses found that prevalence varied between PE subtypes (hallucinations, 6% [95% CI 1–11%], delusions, 45% [95% CI 0–99%]). Pooled results showed that PEs and autistic traits had a weak to medium correlation (r = 0.34 [95% CI 0.27–0.41]). Based on our meta-analysis, PEs seem to be more prevalent in individuals with autism spectrum disorder/autistic traits than in the general population, but this finding may vary according to the PE subtype. Future studies should focus on statistical results for each PE subtype separately. More studies should be conducted to clarify the relationship between autism spectrum disorder/autistic traits and PEs by subtype.

Long and short sleep duration and psychotic symptoms in adolescents: Findings from a cross-sectional survey of 15 786 Japanese students
Ryo Morishima; Syudo Yamasaki; Shuntaro Ando; Shinji Shimodera; Yasutaka Ojio; Yuji Okazaki; Kiyoto Kasai; Tsukasa Sasaki; Atsushi Nishida
Psychiatry Research, Aug. 2020, [Reviewed]

Living in temporary housing and later psychological distress after the Great East Japan Earthquake of 2011: A cross-lagged panel model
Ryo Morishima; Satoshi Usami; Shuntaro Ando; Tomoki Kiyono; Masaya Morita; Shinya Fujikawa; Tsuyoshi Araki; Kiyoto Kasai
SSM - Population Health, Aug. 2020, [Reviewed]

Social withdrawal and testosterone levels in early adolescent boys.
Noriyuki Hayashi; Shuntaro Ando; Seiichiro Jinde; Shinya Fujikawa; Naohiro Okada; Rie Toriyama; Mio Masaoka; Hiroshi Sugiyama; Toru Shirakawa; Tomoko Yagi; Masaya Morita; Ryo Morishima; Tomoki Kiyono; Syudo Yamasaki; Atsushi Nishida; Kiyoto Kasai
Psychoneuroendocrinology, 13 Feb. 2020, [Reviewed]
Social withdrawal may lead to mental health problems and can have a large impact on a life course, particularly among boys. To support adolescents with social withdrawal, an integrative understanding of the biological bases would be helpful. Social dominance, a possible opposite of social withdrawal, is known to have positive associations with testosterone levels. A previous study suggested that social withdrawal has a negative relationship with sexual maturity among adolescent boys. However, the relationship between social withdrawal and testosterone in adolescence is unknown. This study aimed to examine whether social withdrawal was negatively associated with testosterone levels in early adolescent boys. Salivary samples were collected from 159 healthy early adolescent boys (mean age [standard deviation]: 11.5 [0.73]) selected from participants of the "population-neuroscience study of the Tokyo Teen Cohort" (pn-TTC). Social withdrawal and confounding factors, such as the secondary sexual characteristics and their age in months, were evaluated by self-administered questionnaires completed by the primary parents. The degree of social withdrawal was assessed with the Child Behaviour Checklist (CBCL). Levels of salivary testosterone, and cortisol as a control, were measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Logistic regression was conducted to examine the association between social withdrawal and testosterone levels. A higher risk of social withdrawal was associated with a lower salivary testosterone level after adjustment for age in months (odds ratio 0.55, 95 % confidence interval 0.33-0.94), and the association remained significant after adjusting for body mass index, the degree of anxiety/depression and pubertal stage. Thus, we found a negative relationship between social withdrawal and testosterone levels in early adolescent boys. These findings may help to clarify the biological foundations of and to develop support for social withdrawal.

The course of chronic and delayed onset of mental illness and the risk for suicidal ideation after the Great East Japan Earthquake of 2011: A community-based longitudinal study.
Ryo Morishima; Shuntaro Ando; Tsuyoshi Araki; Satoshi Usami; Akiko Kanehara; Shintaro Tanaka; Kiyoto Kasai
Psychiatry research, Mar. 2019, [Reviewed]
This study investigated how the course of a mental illness is distributed and evaluated the risk factors and suicidality of chronic and delayed onset mental illness after the Great East Japan Earthquake. The first, second, and third waves of this study were conducted in 2012, 2013, and 2014, respectively. Psychological distress, suicidal ideation, and socio-demographics were assessed by a self-report questionnaire for affected residents (N = 1473; 768 females, 52.1%; average age = 66.3 years, ranged from 20 to 89 years). Prevalence of mental illness was 10.0%, 14.7%, and 11.8% in the first, second, and third waves, respectively. Prevalence of mental illness for three years was found to be 21.4% and of remission, chronic, and delayed-onset course was 5.0% (2.9-7.1%), 3.6% (1.6-5.8%), and 6.2% (4.2-8.4%), respectively. Psychological distress and serious damage to their homes in the first wave predicted chronic course. Psychological distress in the first wave, living at temporary housing, and unemployment in the third wave increased risk for delayed onset. Among the participants, 9.8% reported suicidal ideation. Chronic or delayed onset course showed a higher risk of suicidal ideation. Many residents, who showed high risk of suicidality, still suffer from mental illness requiring housing, occupation, and psychological support.

Mental Health Problems in a Community After the Great East Japan Earthquake in 2011: A Systematic Review
Shuntaro Ando; Hitoshi Kuwabara; Tsuyoshi Araki; Akiko Kanehara; Shintaro Tanaka; Ryo Morishima; Shinsuke Kondo; Kiyoto Kasai
HARVARD REVIEW OF PSYCHIATRY, Jan. 2017, [Reviewed]

COVID-19流行による全国一斉臨時休校期間中のオンライン授業と思春期メンタルヘルスの関連:疫学横断調査による検証
2022

22q11.2欠失症候群のある人の家族を対象としたウェブニーズ調査
2020

優秀演題賞を受賞して 東日本大震災3年経過後の抑うつの長期経過と希死念慮の関係　　　　　　　　　　　　　　　
Dec. 2019, [Invited]
Lead

22q11.2欠失症候群を持つ本人および家族への統合的支援モデル構築にむけたコホート研究:研究計画
2019

トランジション(成人期への移行)と病名告知:22q11.2欠失症候群メンタルヘルス専門外来の経験から
2019

AYA世代をむかえた医療的ケア児とその家族に対する統合的支援 : 身体･知的･精神の重複障害をもつ22q11.2欠失症候群メンタルヘルス専門外来の立ち上げの経験から
Jan. 2019, [Invited]